WO2014203819A1 - ヒドロキシアルキルセルロースを含有するコーティング剤 - Google Patents
ヒドロキシアルキルセルロースを含有するコーティング剤 Download PDFInfo
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- WO2014203819A1 WO2014203819A1 PCT/JP2014/065740 JP2014065740W WO2014203819A1 WO 2014203819 A1 WO2014203819 A1 WO 2014203819A1 JP 2014065740 W JP2014065740 W JP 2014065740W WO 2014203819 A1 WO2014203819 A1 WO 2014203819A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Definitions
- the present invention relates to a coating agent containing hydroxyalkyl cellulose. More specifically, the present invention relates to a coating agent suitable for obtaining a coating film of a solid preparation for pharmaceutical use, agricultural chemical use or food use.
- This application claims priority based on Japanese Patent Application No. 2013-126671 for which it applied to Japan on June 17, 2013, and uses the content here.
- Hydroxypropyl cellulose is a nonionic polymer obtained by etherifying a hydroxyl group in a glucose (C 6 H 10 O 5 ) unit, which is a constituent unit of cellulose, with a hydroxypropyl group. Hydroxypropyl cellulose has a hydroxypropyl group content of 53.4-77.5% by mass, a content of 40-50% by mass, and a content of 5-16% by mass. Yes. In general, those having a content of 5 to 16% by mass are called low-substituted hydroxypropylcellulose (see Patent Document 1, etc.).
- Patent Document 2 proposes hydroxypropyl cellulose having an average number of substituted moles of 2 to 3 having a low ratio of unsubstituted and high-substituted products having a hydroxypropyl group-substituted mole number of 4 or more. This shows that blocking can be prevented in the RH environment.
- Patent Document 3 proposes a coating composition containing low-substituted hydroxypropylcellulose, talc, propylene glycol and polyethylene glycol, and shows that a tablet having no adhesiveness can be provided.
- Patent Document 4 discloses that a coating agent containing hydroxyalkyl cellulose having a hydroxyalkyl group content in the hydroxyalkyl cellulose in the range of 40 to 50% by mass, such as 50 ° C. and 90% RH. This shows that a tablet capable of preventing blocking due to stickiness even in a severe high-temperature and high-humidity environment can be provided.
- JP 2001-31701 A Japanese Patent Laid-Open No. 9-202801 JP 2007-1873 WO2011-027728 JP 2002-207030 A
- An object of the present invention is to provide a coating agent suitable for obtaining a coating film for tablets that has high hardness, little loss due to friction, and can extend the disintegration time.
- a hydroxyalkyl cellulose having a hydroxyalkyl group content of more than 50% by mass and less than 60% by mass with respect to the total mass of the hydroxyalkyl cellulose is 1% by mass to 7% by mass with respect to the total mass of the coating agent.
- the coating agent according to [1] which is used for tablet coating.
- the coating agent of the present invention When the coating agent of the present invention is sprayed on an uncoated tablet and dried, a solid preparation with high hardness, little loss due to friction, and a long disintegration time can be obtained.
- FIG. 1 is a view showing a coated tablet prepared in Example 1.
- FIG. It is a figure which shows the detail of the surface of the coated tablet prepared in Example 1.
- FIG. It is a figure which shows the coated tablet prepared by the comparative example 2.
- the coating agent of the present invention contains hydroxyalkyl cellulose.
- the hydroxyalkyl cellulose can be obtained, for example, by reacting raw material cellulose with sodium hydroxide to make alkali cellulose, and then subjecting alkali cellulose and alkylene oxide to substitution reaction.
- alkylene oxide used for the substitution reaction examples include ethylene oxide and propylene oxide. Of these, propylene oxide is preferred.
- a substitution reaction is performed using propylene oxide, hydroxypropyl cellulose is obtained.
- R represents a divalent hydrocarbon group.
- R is preferably —CH 2 —CH (CH 3 ) or —CH 2 —CH 2 —, and more preferably —CH 2 —CH (CH 3 ).
- m is a natural number of 1 or more.
- the hydroxyalkyl cellulose contained in the coating agent of the present invention has a hydroxyalkyl group content of more than 50% by mass and less than 60% by mass, preferably 51% by mass to 58% by mass, based on the total mass of the hydroxyalkyl cellulose. It is as follows. If the content of the hydroxyalkyl group is within this range, when the coating film is formed, stickiness and hardness deficiency of the coating film are reduced, and blocking is less likely to occur. In addition, content of a hydroxyalkyl group can be calculated
- the content of hydroxyalkyl cellulose with respect to the total mass of the coating agent of the present invention is 1% by mass to 7% by mass, and more preferably 3% by mass to 6% by mass. If the content of hydroxyalkyl cellulose is within this range, a solid preparation suitable for an orally disintegrating tablet can be obtained, particularly in hardness and disintegration time.
- the hydroxyalkyl cellulose used in the present invention has a viscosity of 2% by weight aqueous solution at 20 ° C. of preferably 2.0 to 10.0 mPa ⁇ s, more preferably 3.0 to 5.9 mPa ⁇ s, and still more preferably. 4.7 to 5.9 mPa ⁇ s.
- the viscosity is an index representing the degree of polymerization of hydroxyalkyl cellulose. When the viscosity is in the above range, workability in obtaining a solid preparation such as a granule or a tablet is improved.
- the coating agent of the present invention can be obtained by dissolving or dispersing hydroxyalkyl cellulose in a solvent.
- a solvent usually, water or an organic solvent such as acetone, ethanol, isopropyl alcohol, and the like can be used, and water is preferably used from the viewpoint of safety such as environmental aspect and residual solvent.
- the content of the solvent with respect to the total mass of the coating agent of the present invention is preferably 80% by mass or more and 98% by mass or less, more preferably 85% by mass or more and 97% by mass or less, and 90% by mass or more and 97% by mass. More preferably, it is at most mass%.
- the coating agent of the present invention may contain a known compounding agent generally used as a coating agent for tablets in addition to hydroxyalkyl cellulose.
- compounding agents include powders such as talc, titanium oxide, yellow ferric oxide, ferric oxide, legal dyes, light anhydrous silicic acid, hydrous silicon dioxide, and the like; polyethylene glycol, polypropylene glycol, triethyl citrate, glycerol mono , Di- or triacetate, 1,2-propylene glycol, castor oil, dibutyl sebacate, diethyl phthalate, polyethylene glycol methyl ether, phospholipid, lecithin and other lubricants (plasticizer); sucrose, polyvinyl pyrrolidone, dextrose, sorbitol, mannitol Adhesion promoters such as sucrose, polyvinylpyrrolidone, lactose, starch, sodium starch glycolate, ethyl cellulose and maltodextrins;
- a lubricant (plasticizer) is preferably included.
- the content of the lubricant is preferably about 5% by mass to 15% by mass, and more preferably 7% by mass to 12% by mass with respect to the mass of the hydroxyalkyl cellulose.
- a solid preparation having a disintegration time and hardness suitable particularly for an orally disintegrating tablet can be obtained.
- the uncoated tablet or granulated product coated with the coating agent of the present invention can be produced by a usual production method. For example, by kneading drugs and excipients, binders, disintegrants, lubricants, etc. with a small amount of water or organic solvent, etc., then granulating, drying, sizing, and if necessary through a tableting process Appropriate size uncoated tablets or granules can be produced.
- the amount (coating rate) of the coating agent of the present invention coated on the uncoated tablet or granulated product is preferably 2 to 6% by mass, more preferably 3 to 5% by mass, and still more preferably 4 to 5% by mass. is there.
- the coating rate is calculated by the following formula. When the coating rate is in the above range, a solid preparation having high hardness and disintegration time particularly suitable for orally disintegrating tablets can be obtained.
- the dry thickness of the coating film is preferably 30 to 80 ⁇ m, more preferably 40 to 70 ⁇ m, still more preferably 45 to 65 ⁇ m.
- the coating can be usually carried out using a sugar-coated pan or a breathable coating apparatus, usually at room temperature, optionally at 20 to 200 ° C.
- the coating is preferably performed by a spray method.
- the air supply is preferably 50 to 70 ° C.
- the air volume during spray coating is preferably 0.4 to 0.6 m 3 / min.
- the static pressure (gauge pressure) during spray coating is preferably -5 to -15 Pa.
- the spray pressure (gauge pressure) during spray coating is preferably 0.5 to 1.5 MPa.
- the tablet charge during spray coating is preferably 0.31 to 0.54 g / cm 3 (brimm amount).
- the liquid speed during spray coating is preferably 3 to 5 mL / min.
- the amount of spray liquid during spray coating is preferably 300 to 560 g (3 to 8% by mass as solid content).
- Examples of the form of the solid preparation to be obtained include coated tablets, coated granules, and coated fine granules. Furthermore, the solid preparation obtained in the present invention can be made into a sugar-coated tablet or the like. Further, when gloss is required, waxing with carnauba wax or the like can be performed according to a conventional method.
- Example 1 Preparation of uncoated tablets 70 parts by mass of lactose for direct compression, 30 parts by mass of corn starch, and 0.5 parts by mass of magnesium stearate were mixed, and the tableting pressure was 10 kN using a tableting machine (VELA5) manufactured by Kikusui Seisakusho. Uncoated tablets were produced by tableting with a tablet size of 8 mm ⁇ -R tablets (200 mg / T).
- the temperature in the reactor was lowered to 45 ° C. or lower. After 1 hour from the start of cooling, the temperature was raised to 85 ° C. and maintained at 85 ° C. for 1.5 hours. Thereafter, the temperature in the reactor was lowered to 40 ° C. or lower.
- the product was washed out of the reactor with hot water. The washed product was put into a flask and toluene was distilled off. After distilling off, the resulting liquid was allowed to stand. The gel settled. The supernatant liquid was extracted. Hot water was poured into the gel, stirred for 10 minutes, and allowed to stand again. The gel settled. The supernatant liquid was extracted. Hot water was poured into the gel.
- the viscosity of the obtained hydroxypropylcellulose (A) in a 2% aqueous solution at 20 ° C. was 4.88 mPa ⁇ s.
- the viscosity was measured with a digital viscometer / B type viscometer (Brookfield DV-II + Pro) in a 2% aqueous solution at 20 ° C. and 60 rpm.
- the coated tablet of the present invention was manufactured by spraying at a pressure of 0.1 MPa, a pan rotation speed of 20 rpm, a tablet charging amount of 300 g, a liquid speed of 3 to 4 mL / min, and a spray liquid amount of 300 g (15 g as HPC solid content).
- a microscopic image of the coated tablet of the present invention is shown in FIGS.
- Tablet hardness and tablet thickness are average values of 10 tablets measured by a load cell type tablet hardness tester portable checker (Okada Seiko Co., Ltd., PC-30 type).
- the tablet weight is an average value of 10 tablets measured by an electronic balance.
- the friability is an average value of 30 tablets of friability (25 rpm, 100 revolutions) measured by a tablet friability tester (Toyama Sangyo Co., Ltd. TFT-1200 type).
- the disintegration time is an average value of 6 tablets of disintegration time measured with 37 ° C. distilled water using a disintegration tester (Toyama Sangyo Co., Ltd., NT-2 type).
- the coating film thickness is an average value of 10 tablets of the coating film thickness calculated by the following formula.
- Comparative Example 1 The content of the hydroxypropyl group was 45.5% by mass in the same manner as in Example 1 except that the amount of propylene oxide added was 3.68 in terms of the molar ratio to the pulp. Hydroxypropyl cellulose (B) having a viscosity at 20 ° C. of 4.08 mPa ⁇ s was obtained. Coated tablets were produced in the same manner as in Example 1 except that hydroxypropylcellulose (A) used in Example 1 was changed to hydroxypropylcellulose (B). In the same manner as in Example 1, the hardness, thickness, weight, disintegration time, friability, and coating film thickness of this coated tablet were measured, and the coating rate was calculated. The results are shown in Table 1.
- Comparative Example 2 Except that the amount of propylene oxide added was 7.35 in terms of molar ratio to pulp, the hydroxypropyl group content was 63.8% by mass in the same manner as in Example 1, and the 2% by mass aqueous solution Hydroxypropyl cellulose (C) having a viscosity at 20 ° C. of 4.54 mPa ⁇ s was obtained.
- Coated tablets were produced in the same manner as in Example 1 except that hydroxypropylcellulose (A) used in Example 1 was changed to hydroxypropylcellulose (C). A microscopic image of the coated tablet is shown in FIGS. In the same manner as in Example 1, the hardness, thickness, weight, disintegration time, friability, and coating film thickness of this coated tablet were measured, and the coating rate was calculated. The results are shown in Table 1.
- Example 1 had a smooth surface as shown in FIGS.
- Comparative Example 2 has a rough surface as shown in FIGS. 3 and 4, and there is a part that is peeled off. The uniformity of the effect was inferior.
- the coating agent of the present invention When the coating agent of the present invention is sprayed on an uncoated tablet and dried, a solid preparation with high hardness, loss due to friction, and long disintegration time can be obtained.
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Abstract
Description
本願は、2013年6月17日に日本に出願された特願2013-126671号に基づき優先権を主張し、その内容をここに援用する。
そこで、特許文献2は、無置換体及びヒドロキシプロピル基置換モル数4以上の高置換体の比率が低い平均置換モル数2~3のヒドロキシプロピルセルロースを提案し、これによって、25℃、75%RH環境下において、ブロッキングを防止できたことを示している。
更に、特許文献4は、ヒドロキシアルキルセルロース中のヒドロキシアルキル基の含有量が40~50質量%の範囲にあるヒドロキシアルキルセルロースを含有するコーティング剤を用いることによって、50℃、90%RHのような厳しい高温高湿度環境下においても、べたつきによるブロッキングを防止できる錠剤を提供できたことを示している。
〔1〕 ヒドロキシアルキル基の含有量がヒドロキシアルキルセルロースの総質量に対して50質量%超60質量%以下のヒドロキシアルキルセルロースを、コーティング剤の総質量に対して、1質量%以上7質量%以下含有するコーティング剤。
〔2〕 錠剤のコーティングに用いられる〔1〕に記載のコーティング剤。
〔3〕 ヒドロキシアルキルセルロースの2質量%水溶液の20℃における粘度が3.0~5.9mPa・sの範囲にある〔1〕又は〔2〕に記載のコーティング剤。
〔4〕 ヒドロキシアルキル基がヒドロキシプロピル基である〔1〕~〔3〕のいずれか1項に記載のコーティング剤。
〔5〕 前記〔1〕~〔4〕のいずれか1項に記載のコーティング剤でコーティングされた固形製剤。
〔6〕 コーティング率が2~6質量%である〔5〕に記載の固形製剤。
該ヒドロキシアルキルセルロースは、例えば、原料のセルロースに、水酸化ナトリウムを作用させてアルカリセルロースとし、次いでアルカリセルロースとアルキレンオキサイドとを置換反応させることによって得ることができる。
この置換反応によってセルロースのグルコース環単位中の-OH基の一部または全部が-O-(RO)m-H基に置換される。ここでRは2価の炭化水素基を表す。Rは、-CH2-CH(CH3)又は-CH2-CH2-であることが好ましく、-CH2-CH(CH3)であることがより好ましい。mは1以上の自然数である。
置換反応の後、反応液に、酢酸や塩酸等の酸を加えて水酸化ナトリウムを中和し、次いで精製することができる。
溶媒としては、通常、水または、アセトン、エタノール、イソプロピルアルコールなどの有機溶剤を用いることができ、環境面、残留溶媒等の安全性の観点から水が好ましく用いられる。
本発明のコーティング剤の総質量に対する前記溶媒の含有量は、80質量%以上98質量%以下であることが好ましく、85質量%以上97質量%以下であることがより好ましく、90質量%以上97質量%以下であることがより更に好ましい。
これらの中でも、滑剤(可塑剤)が好ましく含まれる。前記滑剤の含有量は、前記ヒドロキシアルキルセルロースの質量に対して、5質量%以上15質量%以下程度であることが好ましく、7質量%以上12質量%以下であることがより好ましい。前記滑剤がこの範囲にあれば、特に口腔内崩壊錠に適した崩壊時間や硬度を有する固形製剤を得ることができる。
素錠の調製
直打用乳糖70質量部、コーンスターチ30質量部、およびステアリン酸マグネシウム0.5質量部を混合し、菊水製作所社製の打錠機(VELA5)を用いて、打錠圧10kN、錠剤サイズ8mmφ-R錠(200mg/T)、で打錠成形して、素錠を製造した。
攪拌機付の反応器に、粉砕パルプ176gを入れ、それに20%NaOH水溶液68.2gを添加し、次いでトルエン602gを添加した。30分間攪拌して反応器内温度を30℃に調整した。反応器内を攪拌しながら、窒素で加圧して、マーセル化反応を1時間行った。
脱圧した後、プロピレンオキサイドを添加した。この時のプロピレンオキサイドの添加量は、パルプに対するモル比で、4.92であった。
次いで、反応器内温度を約80℃に上げた。攪拌しながら、80℃で約1時間保持し、エーテル化反応を行った。反応器内温度を45℃以下に下げた。冷却開始から1時間経過後に85℃に温度を上げ、85℃を1.5時間維持した。その後、反応器内温度を40℃以下に下げた。
反応器から生成物を熱湯で洗い出した。洗い出された生成物をフラスコにいれトルエンを留去した。留去後、得られた液を静置した。ゲルが沈降した。上澄み液を抜き取った。
ゲルに熱湯を注ぎ入れ、10分間攪拌し、再び静置した。ゲルが沈降した。上澄み液を抜き取った。ゲルに熱湯を注ぎ入れた。これに、約85℃で攪拌しながら、60%酢酸をpHが4.9以下となるまで十分間毎に添加した。90℃に調整し、攪拌しながら粘度調整剤を所定量添加した。90℃で14時間攪拌した。
これに、約85℃で攪拌しながら、20%NaOH水溶液をpH7.5となるまで十分間毎に添加した。得られた液を静置した。ゲルが沈降した。上澄み液を抜き取った。ゲルに熱湯を注ぎ入れた。10分間攪拌し、再び静置した。ゲルが沈降した。上澄み液を抜き取った。
ゲルをフラスコから取り出し、フッ素樹脂製の平板に流延した。70℃で真空乾燥し、ヒドロキシプロピル基の含有量が53.0質量%となるヒドロキシプロピルセルロース(A)を得た。
ヒドロキシプロピルセルロース(A) 5質量部、ポリエチレングリコール(PEG6000)0.5質量部、着色剤(黄色5号)0.01質量部、および蒸留水94.49質量部を混合し、噴霧液を調製した。
前記素錠に、該噴霧液を、フロイント産業社製コーティング装置(Hi-Coater LABO、パンサイズ20 型)を用いて、給気60℃、風量0.5m3/min、静圧-10Pa、スプレー圧0.1MPa、パン回転数20rpm、錠剤仕込量300g、液速度3~4mL/min、および噴霧液量300g(HPC固形分として15g)、にて噴霧し、本発明のコーティング錠を製造した。本発明のコーティング錠の顕微鏡像を図1および図2に示す。
プロピレンオキサイドの添加量を、パルプに対するモル比で、3.68とした以外は、実施例1と同様の方法により、ヒドロキシプロピル基の含有量が45.5質量%であり、2質量%水溶液の20℃における粘度が4.08mPa・sであるヒドロキシプロピルセルロース(B)を得た。
実施例1で用いたヒドロキシプロピルセルロース(A)をヒドロキシプロピルセルロース(B)に変えた以外は実施例1と同じ手法にてコーティング錠を製造した。実施例1と同じ方法で、このコーティング錠の硬度、厚み、重量、崩壊時間、摩損度、ならびにコーティング膜厚を測定し、コーティング率を算出した。結果を表1に示す。
プロピレンオキサイドの添加量を、パルプに対するモル比で、7.35とした以外は、実施例1と同様の方法により、ヒドロキシプロピル基の含有量が63.8質量%であり、2質量%水溶液の20℃における粘度が4.54mPa・sであるヒドロキシプロピルセルロース(C)を得た。
実施例1で用いたヒドロキシプロピルセルロース(A)をヒドロキシプロピルセルロース(C)に変えた以外は実施例1と同じ手法にてコーティング錠を製造した。該コーティング錠の顕微鏡像を図3および図4に示す。実施例1と同じ方法で、このコーティング錠の硬度、厚み、重量、崩壊時間、摩損度、ならびにコーティング膜厚を測定し、コーティング率を算出した。結果を表1に示す。
Claims (6)
- ヒドロキシアルキル基の含有量がヒドロキシアルキルセルロースの総質量に対して50質量%超60質量%以下のヒドロキシアルキルセルロースを、コーティング剤の総質量に対して、1質量%以上7質量%以下含有するコーティング剤。
- 錠剤のコーティングに用いられる請求項1に記載のコーティング剤。
- ヒドロキシアルキルセルロースの2質量%水溶液の20℃における粘度が3.0~5.9mPa・sの範囲にある請求項1又は2に記載のコーティング剤。
- ヒドロキシアルキル基がヒドロキシプロピル基である請求項1~3のいずれか1項に記載のコーティング剤。
- 請求項1~4のいずれか1項に記載のコーティング剤でコーティングされた固形製剤。
- コーティング率が2~6質量%である請求項5に記載の固形製剤。
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/893,964 US20160199307A1 (en) | 2013-06-17 | 2014-06-13 | Coating agent comprising hydroxyalkyl cellulose |
KR1020157033070A KR101711876B1 (ko) | 2013-06-17 | 2014-06-13 | 히드록시알킬 셀룰로오스를 함유하는 코팅제 |
SI201431093T SI3011973T1 (sl) | 2013-06-17 | 2014-06-13 | Obložno sredstvo, ki vsebuje hidroksialkilcelulozo |
CN201480032883.2A CN105283204A (zh) | 2013-06-17 | 2014-06-13 | 含有羟烷基纤维素的包衣剂 |
JP2015522881A JP6059805B2 (ja) | 2013-06-17 | 2014-06-13 | ヒドロキシアルキルセルロースを含有するコーティング剤 |
ES14813986T ES2715382T3 (es) | 2013-06-17 | 2014-06-13 | Agente de recubrimiento que contiene hidroxialquilcelulosa |
CA2912043A CA2912043C (en) | 2013-06-17 | 2014-06-13 | Coating agent comprising hydroxyalkyl cellulose |
MX2015015027A MX362930B (es) | 2013-06-17 | 2014-06-13 | Agente de recubrimiento que comprende celulosa de hidroxialquilo. |
BR112015030617-9A BR112015030617B1 (pt) | 2013-06-17 | 2014-06-13 | formulação sólida |
EP14813986.8A EP3011973B1 (en) | 2013-06-17 | 2014-06-13 | Coating agent containing hydroxyalkyl cellulose |
HRP20190360TT HRP20190360T1 (hr) | 2013-06-17 | 2019-02-25 | Obložno sredstvo koje sadrži hidroksialkilcelulozu |
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US (1) | US20160199307A1 (ja) |
EP (1) | EP3011973B1 (ja) |
JP (1) | JP6059805B2 (ja) |
KR (1) | KR101711876B1 (ja) |
CN (1) | CN105283204A (ja) |
BR (1) | BR112015030617B1 (ja) |
CA (1) | CA2912043C (ja) |
ES (1) | ES2715382T3 (ja) |
HR (1) | HRP20190360T1 (ja) |
HU (1) | HUE042777T2 (ja) |
MX (1) | MX362930B (ja) |
PT (1) | PT3011973T (ja) |
SI (1) | SI3011973T1 (ja) |
TR (1) | TR201902206T4 (ja) |
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CN106138003A (zh) * | 2016-07-11 | 2016-11-23 | 成都中牧生物药业有限公司 | 一种稳定型薄膜包衣预混剂及制备方法 |
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2014
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- 2014-06-13 TR TR2019/02206T patent/TR201902206T4/tr unknown
- 2014-06-13 SI SI201431093T patent/SI3011973T1/sl unknown
- 2014-06-13 CN CN201480032883.2A patent/CN105283204A/zh active Pending
- 2014-06-13 US US14/893,964 patent/US20160199307A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
ES2715382T3 (es) | 2019-06-04 |
BR112015030617A2 (pt) | 2017-07-25 |
TR201902206T4 (tr) | 2019-03-21 |
HRP20190360T1 (hr) | 2019-04-05 |
JP6059805B2 (ja) | 2017-01-11 |
EP3011973A1 (en) | 2016-04-27 |
TWI496844B (zh) | 2015-08-21 |
KR20150144800A (ko) | 2015-12-28 |
KR101711876B1 (ko) | 2017-03-03 |
US20160199307A1 (en) | 2016-07-14 |
TW201512318A (zh) | 2015-04-01 |
PT3011973T (pt) | 2019-03-25 |
MX362930B (es) | 2019-02-26 |
SI3011973T1 (sl) | 2019-03-29 |
EP3011973A4 (en) | 2017-02-15 |
CA2912043A1 (en) | 2014-12-24 |
CN105283204A (zh) | 2016-01-27 |
BR112015030617B1 (pt) | 2020-12-22 |
HUE042777T2 (hu) | 2019-07-29 |
MX2015015027A (es) | 2016-03-09 |
JPWO2014203819A1 (ja) | 2017-02-23 |
CA2912043C (en) | 2017-08-15 |
EP3011973B1 (en) | 2019-01-16 |
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