WO2014065303A1 - Composition externe pour la peau - Google Patents

Composition externe pour la peau Download PDF

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Publication number
WO2014065303A1
WO2014065303A1 PCT/JP2013/078642 JP2013078642W WO2014065303A1 WO 2014065303 A1 WO2014065303 A1 WO 2014065303A1 JP 2013078642 W JP2013078642 W JP 2013078642W WO 2014065303 A1 WO2014065303 A1 WO 2014065303A1
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WIPO (PCT)
Prior art keywords
acid
skin
composition
component
carboxyvinyl polymer
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PCT/JP2013/078642
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English (en)
Japanese (ja)
Inventor
幸恵 武田
温子 中田
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ロート製薬株式会社
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Priority to JP2014543315A priority Critical patent/JPWO2014065303A1/ja
Publication of WO2014065303A1 publication Critical patent/WO2014065303A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a composition for external use containing a carboxyvinyl polymer or an alkyl-modified carboxyvinyl polymer, a non-vegetable polysaccharide thickener, and at least one selected from the group consisting of hydroxymonocarboxylic acid, hydroxydicarboxylic acid and phytic acid. About.
  • Carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer are thickeners widely used in skin external compositions, but the expected viscosity is not obtained or obtained in the presence of salt, high pH, and low pH conditions. However, there is a problem that it fluctuates with time.
  • xanthan gum has high thickening stability in a wide pH range and is excellent in heat resistance, salt resistance, acid resistance and alkali resistance, and is therefore used as a thickening stabilizer in cosmetics (Non-patent Document 1). .
  • Patent Document 1 discloses that in a skin external preparation containing a carboxyvinyl polymer or an alkyl-modified carboxyvinyl polymer, the effect of ultraviolet rays and the decrease in viscosity due to the addition of salt are prevented, and product safety and stability are not deteriorated. Therefore, it is disclosed that xanthan gum or carrageenan and hydroxypropyl cellulose or hydroxyethyl cellulose are blended.
  • Patent Document 2 discloses a sclerotium gum 0.005 as a high-viscosity cosmetic composition having a sufficiently favorable appearance in appearance, which is effective even in the presence of a water-soluble vitamin that can function as an electrolyte or at a low pH.
  • Cosmetic compositions containing ⁇ 1%, a hydrophobically modified acrylate or methacrylate copolymer, such as an alkyl-modified carboxyvinyl polymer, 0.005-1% and a cosmetically acceptable carrier are disclosed.
  • carbopol 1382 (2% active) is 8.000 wt%
  • sclerotium gum (Amigel (registered trademark)) is 0.170 wt%
  • lactic acid is 0.010 wt%.
  • a composition of sunscreen lotion containing% by weight is disclosed.
  • xanthan gum, carrageenan, hydroxypropyl cellulose, hydroxyethyl cellulose and sclerotium gum are blended to stabilize the viscosity of a highly viscous composition containing a carboxyvinyl polymer against pH and salt. It has been broken.
  • the present invention solves such problems associated with the prior art, achieves a stable viscosity in the low pH region, suppresses odor, and can sufficiently contain an organic acid or the like.
  • the purpose is to provide.
  • a hydroxy monoester is further added in a composition in which a carboxyvinyl polymer or an alkyl-modified carboxyvinyl polymer is blended with a non-vegetable polysaccharide thickener. At least one selected from the group consisting of carboxylic acid, hydroxydicarboxylic acid and phytic acid is blended, and among these acids, lactic acid is more than the amount shown in the prior art even though this is the source of odor. It has been found that, by blending, and particularly by blending a specific amount of other specific acids, it is possible to maintain the viscosity stability of the composition for external use in the low pH region and to suppress odor. Thus, the present invention has been completed.
  • the gist of the present invention is as follows. ⁇ 1> (A) a carboxyvinyl polymer or an alkyl-modified carboxyvinyl polymer, (B) a non-vegetable polysaccharide thickener, and (C) at least selected from the group consisting of hydroxymonocarboxylic acid, hydroxydicarboxylic acid and phytic acid An external composition for skin containing one type (however, in the case of lactic acid, 0.1 to 20% by weight).
  • the content of component (C) in the external composition for skin is 0.0001 to 20% by weight (provided that 0.1 to 20% in the case of lactic acid) with respect to the total external composition for skin.
  • ⁇ 3> The external composition for skin according to ⁇ 1> or ⁇ 2>, wherein the hydroxy monocarboxylic acid and hydroxydicarboxylic acid have 1 to 10 hydroxyl groups and 2 to 10 carbon atoms.
  • the component (C) is at least one selected from the group consisting of gluconic acid, glycolic acid, lactic acid, malic acid, tartaric acid, salicylic acid, pantothenic acid, glycyrrhetinic acid and phytic acid, ⁇ 1> to ⁇ 3 >
  • the external composition for skin according to any one of the above.
  • ⁇ 5> The external composition for skin according to any one of ⁇ 1> to ⁇ 4>, wherein the pH is 6 or less.
  • ⁇ 6> The external composition for skin according to any one of ⁇ 1> to ⁇ 5>, wherein the non-plant polysaccharide thickener (B) is sclerotium gum or xanthan gum.
  • a method for stabilizing the viscosity of an external composition for skin characterized in that it comprises blending at least one member selected from the group consisting of (in the case where component (C) is lactic acid, the entire composition obtained by blending lactic acid) Lactic acid is blended in a proportion of 0.1 to 20% by weight of the amount).
  • a composition for external use containing (A) a carboxyvinyl polymer or an alkyl-modified carboxyvinyl polymer and (B) a non-vegetable polysaccharide thickener, comprising (C) hydroxymonocarboxylic acid, hydroxydicarboxylic acid and phytic acid.
  • a method for suppressing odor of an external composition for skin characterized in that it contains at least one selected from the group (however, when component (C) is lactic acid, the total amount of the composition obtained by blending lactic acid) Of these, lactic acid is blended at a ratio of 0.1 to 20% by weight).
  • an external composition for skin that can achieve a stable viscosity in a low pH region, can suppress odors, and can sufficiently contain an organic acid or the like.
  • the external composition for skin of the present invention comprises (A) a carboxyvinyl polymer or an alkyl-modified carboxyvinyl polymer, (B) a non-vegetable polysaccharide thickener, and (C) a hydroxymonocarboxylic acid, hydroxydicarboxylic acid, and phytic acid. It contains at least one selected from the group consisting of (predetermined amount for lactic acid), and by using these together, particularly by containing a certain amount or more of component (C), stable viscosity and odor suppression are simultaneously achieved. be able to.
  • the components (A) to (C), which are essential components of the external composition for skin of the present invention, and other components that are optional components will be described below.
  • the carboxyvinyl polymer (A) used in the present invention is a vinyl polymer mainly composed of acrylic acid having a carboxyl group, methacrylic acid or the like, and gives an appropriate viscosity to the external composition for skin of the present invention.
  • carboxyvinyl polymers there are no particular restrictions on the monomer composition, molecular weight, etc., and various commercially available carboxyvinyl polymers can be used without particular limitation.
  • these commercially available products include Carbopol 940 (Carbopol 940), Carbopol ⁇ ⁇ ⁇ 941 (Carbopol 941), Carbopol 980 (Carbopol 980), and Carbopol 981 (Carbopol 1980) sold by Lubrizol Advanced Materials.
  • an alkyl-modified carboxyvinyl polymer can also be used as the component (A).
  • the alkyl-modified carboxyvinyl polymer (A) is obtained by alkyl-modifying a carboxyvinyl polymer. More specifically, a part or all of the carboxyl groups in the carboxyvinyl polymer are alkyl groups having, for example, about C 10 to C 30. Esterified by
  • the type and molecular weight of the vinyl polymer that is the raw material of the alkyl-modified carboxyvinyl polymer there are no particular restrictions on the type and molecular weight of the vinyl polymer that is the raw material of the alkyl-modified carboxyvinyl polymer, the degree of esterification, the alkyl group used for this purpose, and various commercially available alkyl-modified carboxyvinyls.
  • Polymers can be used. These commercially available products include, for example, Pemulen TR-1 (PEMULEN TR-1), PEMUREN TR-2, Carbopol 1342 (Carbopol 1342) sold by Lubrizol Advanced Materials.
  • Carbopol Ultrez21 Carbopol Ultrez21
  • Carbopol ETD2020 Carbopol ETD2020
  • Carbopol 1382 Carbopol 1382
  • Carbopol AQUA SF-1 Carbopol AQUA SF-1
  • DERMACRYL AQF sold by Akzo Nobel
  • Rubimer Samurai 100P sold by BASF
  • Leoir MS-100 sold by Lion.
  • carboxyvinyl polymer or alkyl-modified carboxyvinyl polymer described above can be used alone or in combination of two or more.
  • the blending amount of the carboxyvinyl polymer or the alkyl-modified carboxyvinyl polymer (A) in the external composition for skin of the present invention is usually 0.01 to 10% by weight with respect to the entire external composition for skin (100% by weight). From the viewpoint of imparting an appropriate viscosity, a feeling of use, and fingering of the preparation to the external composition for skin, it is preferably 0.05 to 3% by weight.
  • Non-vegetable polysaccharide thickener As described in Non-Patent Document 1, Patent Documents 1 and 2, polysaccharide thickeners such as xanthan gum, carrageenan, and sclerotium gum are used as thickening stabilizers, achieving viscosity stabilization in a wide pH range. To do.
  • the inventors of the present invention have recently demonstrated that, among the polysaccharide thickeners, the non-vegetable polysaccharide thickener is particularly excellent in thickening stability even when the component (C) described below is blended as an acid. It was found that the odor was suppressed even in the presence.
  • non-vegetable polysaccharide thickeners examples include sclerotium gum, xanthan gum, curdlan, gellan gum, chitin, and chitosan.
  • the sclerotium gum is a capsule-like ⁇ -D-glucan and can be produced from a fungal species grown in a medium containing glucose or sucrose as a carbon source and a complex nitrogen source to which an inorganic salt is added.
  • a glucan having an estimated degree of polymerization of about 100 is obtained from Sclerotium glucanicum, and a glucan having a degree of polymerization of about 800 is obtained from a Sclerotium olfsii strain.
  • various sclerotium gums differ slightly in the number and length of side chains.
  • sclerotium gum derived from Sclerotium lfsii is commercially available under the trade name Amigel from Alba Muller / Tri K, France.
  • the xanthan gum is a polysaccharide obtained by fermenting hydrocarbons with the genus Xanthomonas, and is composed of glucose, mannose, glucuronic acid and the like.
  • This xanthan gum is excellent in water retention, viscosity, elasticity, and gelling properties, and is widely used as a food, cosmetic and pharmaceutical material such as laxatives and surfactant dispersants in addition to stabilizers such as milk products.
  • various xanthan gums can be used without any particular restrictions, and as commercially available products, for example, Sanace C sold by San-Eigen FFI Co., Ltd. and Kelco are sold. Examples include Celtolol and Echo Gum sold by DSP Gokyo Food & Chemical Co., Ltd.
  • non-vegetable polysaccharide thickener sclerotium gum and xanthan gum are preferred, and sclerotium gum is particularly preferred from the viewpoint of thickening stability and odor suppression effect in combination with component (C).
  • the content of the non-vegetable polysaccharide thickener (B) described above in the composition for external use of the skin of the present invention is usually 0.01 to 10% by weight with respect to the whole composition (100% by weight), preferably Is 0.05 to 5% by weight. Within this concentration range, the composition for external use on the skin can be smoothly applied to the skin, the skin feels good after application, and the feel of the preparation is good, and sufficient viscosity is maintained.
  • non-vegetable polysaccharide thickeners can be used alone or in combination of two or more.
  • composition for external use of skin of this invention contains at least 1 type (C) chosen from the group which consists of hydroxymonocarboxylic acid, hydroxydicarboxylic acid, and phytic acid (it contains predetermined amount about lactic acid).
  • C hydroxymonocarboxylic acid
  • hydroxydicarboxylic acid a compound having a hydroxyl group in the molecule and one carboxyl group
  • hydroxy dicarboxylic acid is a compound having a hydroxyl group in the molecule and two carboxyl groups. It is.
  • the hydroxymonocarboxylic acid and hydroxydicarboxylic acid usually have 1 to 10, preferably 1 to 5 hydroxyl groups, and usually have 2 to 10 carbon atoms, preferably 2 to 8 carbon atoms. It is a piece.
  • the phytic acid is a hexaphosphate ester of myo-inositol and is a component contained in grains and beans.
  • (C) component which is at least 1 type chosen from the group which consists of such a hydroxymonocarboxylic acid, hydroxydicarboxylic acid, and phytic acid raises the stability of the viscosity of the external composition of this invention, and only suppresses an odor.
  • the composition has an effect of giving a familiar feeling to use, a keratin softening effect, a moisturizing effect, a peeling effect, and an effect of smoothing the skin.
  • the blending amount of such an organic acid is limited to a certain level or less due to odor, but in the present invention, the component (C), which is an organic acid, is blended in a larger amount than in the past, so that the peeling effect is obtained.
  • a composition for external use that can sufficiently exert the conventionally known effects such as improving the smoothness of the skin, smoothing the skin, and softening and firming the skin. Can be provided.
  • hydroxy monocarboxylic acid examples include gluconic acid, glycolic acid, salicylic acid, pantothenic acid, glycyrrhetinic acid, and lactic acid
  • hydroxy dicarboxylic acid examples include malic acid and tartaric acid.
  • gluconic acid As the component (C), gluconic acid, glycolic acid and lactic acid are preferable from the viewpoint of the effects described above.
  • the component (C) may be added to or present in the external composition for skin in the form of an inorganic salt such as sodium salt or potassium salt or an organic salt such as triethanolamine or arginine.
  • the content of the component (C) in the external composition for skin of the present invention is required to be 0.1 to 20% by weight for lactic acid with respect to the whole composition (100% by weight). Is usually 0.0001 to 20% by weight.
  • the content of component (C) is preferably 0.01 to 10% by weight (however, in the case of lactic acid 0.1 to 10% by weight), more preferably 0.1 to 5% by weight. In such a concentration range, the effect of maintaining the viscosity is exhibited, the influence of discoloration by the acid is relatively small, and there is no problem in terms of stability such as precipitation.
  • ⁇ Ratio of components (A) to (C)> In the composition for external use of the skin of the present invention, the ratio of the component (A) to the component (B) 0.1 to 10 parts by weight. If the ratio is within this range, a sufficient thickening effect can be obtained, good finger picking property can be obtained, the cushioning property of the external preparation for skin can be applied smoothly, and the skin can be smoothly applied after application.
  • the ratio of the component (A) to the component (C) is usually 0.05 to 200 parts by weight, preferably 0.1 to 100 parts by weight for the component (C) with respect to 1 part by weight of the component (A). . If the ratio is within this range, a sufficient thickening effect can be obtained, good finger picking properties, cushioning properties of the external preparation for skin can be applied smoothly, and smoothness of the skin after application can be imparted. The smell of can also be suppressed.
  • composition for external use of the skin of the present invention comprises the above-described carboxyvinyl polymer or alkyl-modified carboxyvinyl polymer (A), non-vegetable polysaccharide thickener (B), hydroxymonocarboxylic acid, hydroxydicarboxylic acid and phytic acid.
  • a moisturizing component such as catechol, peptide or derivative thereof, amino acid or derivative thereof, washing component, antibacterial component, keratin softening component, cell activation component, anti-aging component, blood circulation promoting component, whitening component, etc. You may include in the range which does not impair.
  • these other components may be used individually by 1 type, or may be used in combination of 2 or more type.
  • the moisturizing component examples include diglycerin trehalose; high molecular compounds such as sodium hyaluronate, heparin-like substance, chondroitin sulfate sodium, collagen, elastin, keratin, chitin, chitosan; amino acids such as glycine, aspartic acid, arginine; urea And natural moisturizing factors such as sodium pyrrolidone carboxylate; lipids such as ceramide, cholesterol and phospholipid; and plant extract extracts such as chamomile extract, hamamelis extract, tea extract and perilla extract.
  • diglycerin trehalose high molecular compounds such as sodium hyaluronate, heparin-like substance, chondroitin sulfate sodium, collagen, elastin, keratin, chitin, chitosan
  • amino acids such as glycine, aspartic acid, arginine
  • the polyhydric alcohol is preferably one having 2 to 10 carbon atoms, such as glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, sorbitol.
  • glycerin diglycerin
  • triglycerin propylene glycol
  • dipropylene glycol 1,3-butanediol
  • ethylene glycol diethylene glycol
  • isoprene glycol sorbitol.
  • Xylitol erythritol, mannitol, pentanediol, hexanediol, octanediol, decanediol, neopentyl glycol and the like.
  • diglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, and hexanediol are more preferable.
  • Examples of the scrub agent include apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride grain, olive kernel powder, dried sea water grain, candelilla wax, walnut shell powder, cherry core powder, coral powder, charcoal powder. , Hull paste powder, polyethylene powder, silicic anhydride and the like.
  • ultraviolet ray absorbing component examples include octyl triazone, dimethoxybenzylidene dioxoimidazolidine propionate octyl, 2-methoxyhexyl paramethoxycinnamate, phenylbenzimidazole sulfonic acid, and the like.
  • Examples of the ultraviolet scattering component include hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, zinc oxide, zirconium oxide, cerium oxide, titanium oxide, iron oxide, and anhydrous silicic acid, and those inorganic compounds Coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica and talc, or compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene and nylon, and silicone oil and fatty acid aluminum salts, etc. And the like processed with.
  • anti-inflammatory agent examples include glycyrrhizic acid derivatives, azulene, components derived from plants (for example, Comfrey), zinc oxide, tocopherol acetate, aminocaproic acid, and hydrocortisone.
  • Examples of the converging component include zinc oxide, zinc sulfate, aluminum chloride, zinc sulfocolate and tannic acid.
  • vitamins examples include vitamin E such as dl- ⁇ -tocopherol, dl- ⁇ -tocopherol acetate, dl- ⁇ -tocopherol succinate, dl- ⁇ -tocopherol calcium succinate; riboflavin, flavin mononucleotide, flavin adenine disulfide Vitamin B2 such as nucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5′-phosphate sodium, riboflavin tetranicotinate; nicotinic acid, nicotinic acid dl- ⁇ -tocopherol, benzyl nicotinate, methyl nicotinate, Nicotinic acids such as ⁇ -butoxyethyl nicotinate, 1- (4-methylphenyl) ethyl nicotinate and nicotinamide; ascorbigen-A, ascorbic acid stearate, ascorbat
  • Examples of the peptide or derivatives thereof include keratin-degrading peptide, hydrolyzed keratin, collagen, collagen derived from fish, atelocollagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, and elastin-degrading Peptide, Conchiolin Degrading Peptide, Hydrolyzed Conchiolin, Silk Proteolytic Peptide, Hydrolyzed Silk, Lauroyl Hydrolyzed Silk Sodium, Soy Proteolytic Peptide, Hydrolyzed Soy Protein, Wheat Protein, Wheat Proteolytic Peptide, Hydrolyzed Wheat Protein, Casein Degradation Peptides, acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.) and the like can
  • amino acids or derivatives thereof examples include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, ⁇ -alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, Examples include methionine, leucine, isoleucine, valine, histidine, taurine, ⁇ -aminobutyric acid, carnitine, carnosine, creatine and the like.
  • cleaning component examples include soaps selected from alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, alkanolamide salts or amino acid salts; cocoyl glutamate Na, cocoyl methyl taurine Na and the like.
  • alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, alkanolamide salts or amino acid salts
  • cocoyl glutamate Na cocoyl methyl taurine Na and the like.
  • Amino acid surfactants such as laureth sulfate Na; ether carboxylates such as lauryl ether acetate Na; sulfosuccinate salts such as alkylsulfosuccinate Na; coconut oil fatty acid monoethanolamide, coconut oil fatty acid diethanolamine Fatty acid alkanolamides such as sodium chloride; monoalkyl phosphate salts such as sodium lauryl phosphate and polyoxyethylene lauryl ether sodium phosphate; coconut oil fatty acid amide propylene Betaines such as dimethylaminoacetic acid betaine, lauryldimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, laurylhydroxysulfobetaine and lauroylamidoethylhydroxyethylcarboxymethylbetaine hydroxypropyl phosphate
  • Type amphoteric surfactants such as dimethylaminoacetic acid betaine
  • antibacterial component examples include chlorhexidine, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, popidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitive element 101, photosensitive element 201, paraben. Phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, pyroctoolamine, miconazole and the like.
  • Examples of the keratin soft component include urea and sulfur.
  • the cell activating component examples include amino acids such as ⁇ -aminobutyric acid and ⁇ -aminocaproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acids; tannin, flavonoid, saponin, and photosensitizer 301. Can be mentioned.
  • anti-aging component examples include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivative, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, and the like.
  • Examples of the blood circulation promoting component include plants (for example, ginseng, ashitaba, arnica, ginkgo, fennel, enmelio, dutch oak, chamomile, roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake, ginger, hawthorn, and prunus , Cucumber, assembly, thyme, clove, chimpi, capsicum, touki, tonin, spruce, carrot, garlic, butcher bloom, grape, button, maronier, melissa, yuzu, yokuinin, ryokucha, rosemary, rosehip, chimpi, touki, Spruce, peach, apricot, walnut, corn) components: acetylcholine, ictamol, cantalis tincture, gamma oryzanol, cephalanthin, tolazoline, tocov nicotinate Roll, such as hesperidin
  • whitening component examples include tocopherol, arbutin, tranexamic acid, and ascorbic acid derivatives.
  • the pH of the composition for external use of the present invention is in the acidic region because it contains the component (C).
  • the pH is preferably 6 or less, the viscosity of the composition is stably maintained even in a low pH region, the odor is suppressed, and the peeling effect of the component (C) is sufficiently exhibited.
  • the pH is more preferably 2 to 6 and even more preferably 4 to 6 from the point that the characteristic effects of the present invention are exhibited.
  • the pH can be adjusted by the amount of the component (C) or the use of a pH adjuster described later.
  • the method for producing the external composition for skin of the present invention is not particularly limited, and is an essential component carboxyvinyl polymer or alkyl-modified carboxyvinyl polymer (A), non-vegetable polysaccharide thickener (B), and hydroxymonocarboxylic acid, In addition to at least one kind (C) selected from the group consisting of hydroxydicarboxylic acid and phytic acid, various components (such as the above-mentioned other components) necessary for producing a normal skin external composition are appropriately selected and blended. It can be produced by a conventional method.
  • the amount and usage of the composition for external skin of the present invention to the outer skin are not particularly limited, and it can be used by applying, for example, applying an appropriate amount to the outer skin such as the skin several times a day.
  • Examples of the preparation form of the external composition for skin of the present invention include pharmaceuticals, quasi-drugs, and cosmetics.
  • the essential components and other components described above are used as pharmaceuticals, quasi-drugs, or cosmetics.
  • These can be prepared in the form of a pharmaceutical preparation by mixing them with a base or carrier usually used in the above and, if necessary, an additive described later according to a conventional method.
  • the form of the pharmaceutical preparation is not particularly limited, and examples thereof include an ointment, a liquid, a suspension, an emulsifier (emulsion and cream), a gel, a liniment, a lotion, and a poultice.
  • emulsifier emulsion and cream
  • a gel emulsion and cream
  • a liniment emulsion and cream
  • a lotion emultice
  • the form of the quasi-drug or cosmetic preparation is not particularly limited.
  • basic cosmetics such as lotion, milky lotion, cream, cosmetic liquid, pack, hand cream, body lotion, body cream, gel cream;
  • Cosmetics for cleaning such as facial cleansers, makeup removers, body shampoos;
  • makeup cosmetics such as foundations, makeup bases, lip balms, lipsticks, teak colors; bathing agents and the like.
  • the base or carrier includes liquid paraffin, squalane, petrolatum, gelled hydrocarbon (such as plastic base), ozokerite, ⁇ -olefin oligomer, light liquid paraffin and other hydrocarbons; methyl polysiloxane, dimethyl polysiloxane, high Polymerized methylpolysiloxane, cyclic silicone, alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, silicone-alkyl chain co-modified polyether-modified silicone, silicone-alkyl chain co-modified polyglycerin-modified silicone, polyether Silicone oil such as modified branched silicone, polyglycerin modified branched silicone, acrylic silicone, phenyl modified silicone, silicone resin; coconut oil, olive oil, rice bran Oils and fats such as shea butter; waxes such as jojoba oil, miw wax, candelilla wax, lanolin; higher alcohols such as cetanol, ce
  • bases or carriers described above can be used singly or in combination of two or more, and the amount used thereof is appropriately selected from a range known to those skilled in the art.
  • the skin external composition of the present invention is a known additive that is added to pharmaceuticals, quasi-drugs, or cosmetics within a range that does not impair the effects of the present invention, such as surfactants and stabilizers.
  • An antioxidant, a colorant, a pearly luster imparting agent, a dispersant, a chelating agent, a pH adjusting agent, a preservative, a thickener, an irritation reducing agent, and the like can be added.
  • These additives can be used alone or in combination of two or more.
  • surfactant examples include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate.
  • the stabilizer examples include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole, EDTA ⁇ disodium salt, EDTA ⁇ calcium ⁇ disodium salt and the like.
  • antioxidants examples include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, and L-cysteine hydrochloride.
  • Examples of the colorant include inorganic pigments and natural pigments.
  • pearl luster imparting agent examples include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.
  • dispersant examples include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinyl pyrrolidone, methyl vinyl ether / maleic anhydride crosslinked copolymer, and organic acid.
  • pH adjuster examples include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.), organic bases ( Triethanolamine, diisopropanolamine, triisopropanolamine, etc.).
  • preservative examples include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and paraoxybenzoic acid.
  • examples include benzyl, methyl paraoxybenzoate, and phenoxyethanol.
  • thickener examples include cellulose-based thickeners such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxyethylcellulose, guar gum, pectin, pullulan, gelatin, locust bean Gum, agar, polyvinyl alcohol, polyvinyl pyrrolidone, sodium polyacrylate, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, sodium chondroitin sulfate, hyaluronic acid, sodium hyaluronate, (hydroxyethyl acrylate / acryloyldimethyltaurine Na ) Copolymer, (acryloyl dimethyl) Such as Le taurine ammonium / vinylpyrrolidone) copolymers.
  • cellulose-based thickeners such as methylcellulose, ethylcellulose,
  • irritation reducing agent examples include licorice extract, sodium alginate, gum arabic, polyvinylpyrrolidone, licorice extract, sodium alginate and the like.
  • each composition was filled in a 30 mL glass container, and the viscosity at 25 ° C. of each was measured to obtain the initial viscosity. Then, the light irradiation equivalent to 30000 kJ / m ⁇ 2 > was performed in SUNTEST XLS + (Toyo Seiki Seisakusho). After completion of irradiation, the viscosity of each composition at 25 ° C. was measured.
  • the viscosity measurement conditions are as follows.
  • Measurement temperature 25 °C Measured value Viscosity 1 minute after the start of measurement was taken as the measured value. : Number of revolutions 6 rpm, rotor No. M3 The viscosity (25 ° C.) of each of the unirradiated sample and the irradiated sample was measured, the viscosity of the unirradiated sample was taken as 100, the viscosity after irradiation was expressed as a relative viscosity (%), and the viscosity reduction rate (100 -Relative viscosity) was compared.
  • Relative viscosity 100 x Viscosity of irradiated sample (25 ° C) / Viscosity of unirradiated sample (25 ° C)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
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  • Emergency Medicine (AREA)
  • Dermatology (AREA)
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Abstract

La présente invention vise à résoudre les problèmes associés aux techniques conventionnelles et à proposer une composition externe pour la peau qui présente une viscosité stable dans une plage de valeurs pH basses, qui présente une faible odeur et à laquelle puisse être ajouté un acide organique ou similaire en quantité suffisante range. La présente invention concerne une composition externe pour la peau qui comprend (A) un polymère carboxyvinylique ou un polymère carboxyvinylique à modification alkyle, (B) un agent épaississant à base de polysaccharide non végétal et (C) au moins un composant choisi dans le groupe composé d'acide hydroxymonocarboxylique, d'acide hydroxydicarboxylique et d'acide phytique (lorsque de l'acide lactique est utilisé, la quantité d'acide lactique est de 0,1 à 20 % en poids).
PCT/JP2013/078642 2012-10-23 2013-10-23 Composition externe pour la peau WO2014065303A1 (fr)

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