Classifications

• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
  • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
  • G01N27/403—Cells and electrode assemblies
  • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
  • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
  • G01N27/403—Cells and electrode assemblies
  • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
  • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
  • G01N33/0004—Gaseous mixtures, e.g. polluted air
  • G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
  • G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
  • G01N33/0031—General constructional details of gas analysers, e.g. portable test equipment concerning the detector comprising two or more sensors, e.g. a sensor array
• • H—ELECTRICITY
  • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
  • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
  • H10D62/00—Semiconductor bodies, or regions thereof, of devices having potential barriers
  • H10D62/10—Shapes, relative sizes or dispositions of the regions of the semiconductor bodies; Shapes of the semiconductor bodies
  • H10D62/117—Shapes of semiconductor bodies
  • H10D62/118—Nanostructure semiconductor bodies
  • H10D62/119—Nanowire, nanosheet or nanotube semiconductor bodies
  • H10D62/121—Nanowire, nanosheet or nanotube semiconductor bodies oriented parallel to substrates

Definitions

• the present invention relates to a device for detecting a concentration of a substance in a fluid.
• the present invention relates to a nanowire-based device.
• Nanoscale field-effect transistors such as for example silicon nanowire FETs and carbon nanotubes with properly functionalized surfaces
• bio molecules such as proteins and DNA.
• these devices are potentially interesting for sensing gasses as well.
• the nanoscale field-effect transistor In all applications where the nanoscale field-effect transistor is used there is a strong desire for sensing multiple target molecules simultaneously. In a liquid or gas environment, the use of a reference transistor is of crucial and critical importance in order to compensate for time related drift.
• Mass spectrometry is the standard method for gas detection. This technique is sensitive, selective and has a wide dynamic range, but is also costly and sizable. Alternatively, optical detection, more specifically absorption spectroscopy in the infra red (IR), is being used as a gas sensor. This technique is sensitive and selective, but one module can only detect one type of molecule and the measurement equipment is costly and sizable. Electrochemical detection can also be used but does not provide the proper sensitivity or the selectivity.
• US2010/0243990 discloses a nanowire-based sensor device for detecting bio- molecules.
• the devices are based on a silicon nanowire field-effect transistor, where the nanowire can be either n-type or p-type impurity doped.
• the surface of the nanowire is functionalized by molecules that specifically couple to their targeted counterparts.
• the charges on the target molecules affect the conductivity of the nanowire channel like a gate- electrode.
• the inventors have recognized that for practical application of detection devices a high dynamic range is required, often in combination with a low detection limit. It is a problem of the known detector devices that a high sensitivity sensor comes with a low dynamic range..
• a device for detecting a concentration of a substance in a fluid sample According to the invention there is provided a device for detecting a concentration of a substance in a fluid sample.
• a fluid may refer to both a gas and a liquid, and the device is thus suitable for detection of substances in both liquids and gases.
• Substances can be dissolved or suspended in the sample.
• Substances can comprise ions, molecules, molecular complexes, particles. In particular they can be substances that can be present in the fluid in low or high concentrations not known beforehand. Substances may be toxic to life requiring adequate concentration determination and also continuous determination preventing extensive preprocessing
• nanowires are electrically addressable means that it is possible to form an electrical contact to each end of each nanowire in order to perform electrical characterization of the respective nanowires with respect to the nanowire characteristics sensistive for the presense of the substance when the fluid with the substance is brought in the vicinity of the nanowire.
• the nanowires of the plurality of nanowires are individually addressable. To this end, preferably the nanowires are electrically connected in parallel between multiple electrical contact points.
• sequential addressing of the nanowire can be achieved using individual gate structures if the nanowires if they are part of one or more transistors.
• each nanowire is completely individually electrically addressable such that their ends form separate contact points for each nanowire, whether in transistor or not.
• the measurable electrical characteristic of the nanowire is influenced according to quantity of the substance and by measurement of the characteristic the quantity of the substance can thereby be deduced.
• the quantity may be absulute quantity or conentration quantities as in amount of substance per sample volume, sample mass or moles of sample.
• the plurality of nanowires comprises at least two nanowires.
• the amount of nanowires may be equal to and/or larger than 3, 4 5, 10, 20 and even 50. They can be conveniently fabricated in the same patterning process of the device. Each nanowires may be duplicated in order to allow for reliability measurement.
• the insulating material can be any electrically insulating material. The material prevents in first instance shortcircuit of the nanowires with the sample fluid.
• the insulating material preferably is an oxide such as e.g. silicon oxide (Si02) or Titanium oxide (Ti02) or mixtures thereof.
• the insulating material can comprise a surface that is exposed to the sample fluid.
• the sample compartment is arranged such that the sample is brought in the vicinity of, or in contact with each nanowire including at least the insulating material.
• Each of the nanowires covered by the respective insulating material is thus arranged for detecting the presence of the substance in the fluid sample through measurement of an electrical characteristic of the nanowire.
• Any characteristic that is influenced by possible presence of a substance in the sample compartment can be used for the detection purpose.
• the measured electrical characteristic preferably is for example be the current vs. voltage characteristics of the nanowire.
• that characteristic is of a nanowire that is part of a transistor with a gate.
• the quantity (concentration) of a substance in the sample can be determined. Calibration curves can be used if needed.
• the different nanowires of a plurality of nanowires of a device are configured such that the detection range of each individual nanowire is different.
• the detection range is the range between the smallest and the largest detectable amount or concentration of a substance in the fluid sample.
• the smallers amount is defined by the amount of substance that does not give a change in the electrical characteristic of the nanowire, while the largets detectable amount is the amount above which no increase of the same electrical characeristic is further observed, it is related to the saturation signal.
• the total detection range of the detection device is then given by the ensemble of nanowires, i.e it is then the sum of the detection range of each individual nanowire.
• the present invention is based on the realization that a nanowire based detecor with a high dynamic range can be achieved by arranging a number of individually addressable nanowires having different dynamic ranges in parallel for measuring a substance in a fluid.
• the device can be configured so that the total dynamic range of the device is larger than the respective dynamic range of the individual nanowires.
• the nanowires of the plurality of nanowires are configured such that the different detection ranges of each one of the plurality of nanowires together form a substantially continuous detection range that is larger than each different detection range.
• the dynamic range of each of the nanowires is 10
• the dynamic range of a device comprising the two nanowires in combination would be 100.
• the device of the invention is advantageous as now samples do not require dilution before providing them to a sensor in order to prevent saturation.
• a detection device can be made wherein the detection range can be chosen through the number of nanowires and their dynamic range configuration.
• sensitivity of the device can be independently set by configuration of the most sensitive nanowire.
• the device can be desigend to be capable of detecting substances with concentration form 100 ppm or larger dosn to 10 ppb.
• concentration form 100 ppm or larger dosn to 10 ppb.
• the device can accordingly be made using conventional semiconductor materials and is therefore suitable for integration with CMOS-based circuits or with preexisting lab-on-a-chip solutions using well developed fabricaiton techniques and requireing minimum adaptaation of existing fabs processes.
• the device may also advantageously be combined with other types of sensors such as temperature sensors, conductivity sensors etc. Additionally, by selecting different insulating materials for different nanowires, different substances can be detected simultaneously by one device.
• a further advantage of the present invention is that the compatibility with established processing methods means that sensor devices can be fabricated at a relatively low cost.
• Each nanowire of said plurality of nanowires can comprises a surface area and a nanowire volume, wherein the ratio of the surface area and the volume is different for the different nanowires of said plurality of nanowires.
• the larger the ratio the more sensitive the nanowire is to the presence of substance in its neighborhood and vice versa.
• the change of detection range i.e. not necessarily an increase or decrease of the detection range, but simply a different range, comes of ratio comes with a change of the ratio.
• the nanowire may have a detection surface exposed at its side where the sample compartment extends.
• the detection surfac can be s arranged for the detecting of the presence of the substance.
• the length, width or hight (thickness) of the nanowire can be used.
• the length or the width are varied while the thickness (perpendicular to subtrate layer extension) is kept constant.
• the polurality of different dimensions of the nanowires may be defined in one and the same patterning (maks) step again saving further cost.
• the layer wherein the nanowires are made is a uniform thickness deposited layer of semiconductor such as silicon. Hence standard substrates can be used and etch steps to vary thickness of that layer are not needed reducing processing complexity and saving cost.
• the nanowire width is varied while also the length is kept constant for the plurality of nanowires.
• the width of nanowires preferably is in the range 8 nm to 1 micrometer.
• the lower range is in practice limited to smallest feature sizes that can be patterned using lithography or imprint techniques.
• a preferred range is 50 nm to 500 nm.
• a more preferred range is 10 nm to 500 nm.
• Lengths of nanowires may be in between 1 to 10 micrometer. They can be lower than 2 micrometer, lower than 1 micormeter, or lower than 500 nm.
• the thickness of the insulating material and the choice of insulator material covering the nanowire can be changed to implement variations of detection range. Influence of the substance to the characteristics of the nanowire can be through capacitive coupling. Thus, an increase of insulator thickness gives a smaller coupling and less sensitivity and vice versa. Also, variation of material to larger dielectric constant dielectric constant will give increase coupling and increased sensitivity and vice versa. Again adjustment of these parameters comes with different detection range. As the dielectric constant is largely determined by the insulating material which is generally compatible with the substrate materials and processing, the thickness of the layer is the preferred parameter to vary across the nanowires of the polurality of nanowires.
• the thickness is preferably between 1 nm and 10 nm to give a good sensitivity. If increased sensitivity is needed, the thickness is in the range 1 to 4 nm, most preferably 3 nm. If increased reliability with regard to electrical insulation of the insulating materila layer is needed, the thickness preferably is in the range of 6 to 10 nm, most prefrerably 7 nm. A thickness of 5 nm gives a good compromise between sensitivity and reliability.
• a nanowire with a smaller cross section area and a thinner insulating layer will be influenced more by a substance molecule than a wire with a larger area and a thicker insulating layer. Such influence can be via capacitive or inductive changes of the nanowire between situation with substance or without substance.
• the device of the invention may be a pH detction device.
• the insulting layer over the nanowire can be Silicon oxide for this purpose.
• the surface of silicon oxide generally has Si-OH groups of which the H + (substance) is reversibly exchangeable with the sample fluid (preferably comprisin or consiting of water for good definiton of pH).
• the charge of a surface layer of the silicon oxide depends on the pH of the fluid, i.e. high pH reduced bound H + and large O " surface charge and low pH, all groups converted to Si-OH and no charge on the surface.
• the charge determines a.o. the conductivity of the nanowire and that can be used as a characteristic of the nanowire to measure.
• the device may further comprise a functionalization layer arranged on the nanowire or on the insulating material of at least one of the nanowires. Adding specific functionalization layers on one or more of the nanowires makes it possible to tailor the device to detect a particular substance or group of substances. Plain chemical (covalent) reaction of the substance with the functionalizaiton layer can be used. Alternatively molecular recognition through all sorts or non-covalent reactions, adherence effects can be used.
• a layer of Ti0 2 may be arranged as the insulating layer or preferably on the insulating layer of the nanowire to act as a functionalization layer.
• Ti0 2 is known to react with and decompose C0 2
• a C0 2 sensor may be formed.
• NiOx layer can reduce/oxidise in presence of formaldehyde and can be used to construct a nanowire resonsive to formaldehyde.
• Those skilled in the art will know what layers need be used to recognize specific substances or specific groups of substances.
• One example may provide layers for detection of blood markers such as those for detection of cardiac disease.
• the layer is configured to detect carbohydrates or other organic molecules as contamination in e.g. water fluid.
• At least two of the nanowires may have different doping concentrations. Varying the doping of the nanowire is an additional means of influencing the electrical characteristics of the nanowire in order to tailor the properties of the sensor for various applications. For example, different doping can be used to realize different threshold voltages of the nanowires. This may provide different sensitivity to the nanowires.
• the sample compartment may be configured to allow a fluid to flow over the plurality of nanowires. Thereby, a concentration of a flowing fluid can be detected which for example facilitates the integration of the device in existing lab-on-a-chip devices.
• sample compartments may be arranged as an opening in a protective layer so that the contacting structures for electrically contacting the nanowires are protected, thereby preventing a short circuit between the contacting structures in case of a conductive sample fluid.
• the part of the substrate (such as e.g the backside of the substrate) may be used as a gate terminal of a transistor of which at leats one of the nanowires of the plurality of nanowires is part.
• the device then forms a three-terminal device with the backside as gate terminal and the contacting structures as source and drain terminals Using the backside as a gate terminal can be utilized to enhance the current response for an applied voltage, or it can be used as a switch to control if any current at all may flow through the nanowire. Thereby, the electrical characteristics of the nanowire can be controlled by the gate terminal.
• the substrate can be patterned to provide individual gate structures to each nanowire if needed.
• the device may comprise a second sample compartment allowing for simultaneous detection of more than one substance.
• a second sample compartment may be used to provide different fluids in contact with arrays of nanowires in order to perform multiple analyses simultaneously. Additionally, the use of two or more sample compartments may further facilitate having nanowires with different characteristics in different sample compartments. In particular, different wire configurations which due to fabrication process complexity may be difficult to combine in one sample compartment can more easily be achieved by using multiple sample compartments.
• the device can comprise electrical circuitry connected to each of said nanowires of the plurality of nanowires for readout of the nanowires.
• the device can be a measurement device ready to use for sample analysis.
• the electrical circuitry is preferably configured to:
• the device may comprise one or more reference nanowires (each defined according to the invention) that are covered by a reference sample compartment in stead of the sample compartment. Such can be easily integrated. Such nanowires can be used to determine the effect of the sample without the substance and to account for such background signal during detection of the sample.
• a method for determining a concentration of a substance in a sample fluid using a device comprising a plurality of individually addressable nanowires is also provided.
• Measuring the amount or concentration of a substance in a fluid using a high- dynamic range nanowire-based device as described above can be achieved by detecting which of the nanowires are non-saturated and selecting the readout from the most sensitive of the non-saturated nanowires.
• the resulting amount and/or concentration may of course also be derived from a combination of measured non-saturated nanowires, either by averaging the results from the non-saturated wires or through more complex determination algorithms.
• the device is calibrated or that it is otherwise known how the different nanowires respond to different concentrations of a particular substance, thereby making it possible to determine whether a particular nanowire is saturated or not.
• the determined electrical characteristic of the nanowires may advantageously be the current as a function of an applied voltage.
• the device may advantageously be reset by applying a gate voltage so that molecules adhering to the nanowires are removed. It is highly advantageous to be able to reset the device in order to avoid the need to know the measuring history of the device, and also in order to reuse a device one it has been saturated. Accordingly, the device may be reset by applying a voltage to the backside of the substrate acting as a gate terminal. The applied gate voltage is of opposite polarity of the operating gate voltage so that electrostatic repulsion causes the molecules adhering to the nanowires to be released, thereby cleaning and resetting the device.
• the device may advantageously be reset by heating the device so that molecules adhering to said nanowires are removed.
• the device may advantageously be reset by heating the device so that molecules adhering to said nanowires are removed.
• Fig. 1 schematically illustrates a device according to an embodiment of the invention.
• Fig. 2 schematically illustrates nanowires according to various embodiments of the invention
• FIG. 3 schematically outlines a method for manufacturing a device according to an embodiment of the invention.
• Fig. 4 is a flowchart outlining the general steps of the manufacturing method illustrated in Fig. 3.
• a device according to the present invention is mainly discussed with reference to a device comprising silicon nanowires based on an SOI (silicon-on-insulator) substrate. It should be noted that this by no means limits the scope of the present invention which is equally applicable to devices comprising nanowires based on other semiconductor materials which also may be formed on other types of substrates.
• SOI silicon-on-insulator
• Fig. l schematically illustrates a device 100 according to an embodiment of the invention. It should be noted that the device in Fig.1 is not drawn to scale and that the purpose of the drawing merely is to illustrate the general concepts of the invention.
• the device 100 comprises a substrate 102, an insulating layer 104 arranged on the substrate 102, three nanowires 106, 108, 110 arranged in parallel are formed in the top silicon layer of an SOI-substrate.
• conductive contacting structures 112, 114 which lead to contact pads (not shown) for electrically contacting the respective end of each of the nanowires.
• the contacting structures 112, 114 may be seen as the source and drain in a three terminal device where the backside of the substrate 102 is used as a gate terminal. In this case all contacts are individually contatable giving individually addressable nanowires. However either contacts 112 or 114 can be connected together without losing the individual addressign possibility.
• a protective layer (electrically insulating layer) 116 is arranged to cover the contacting structures 112, 114 to prevent electrical short-circuit in case of a conductive fluid.
• An opening 118 in the covering layer forms a sample compartment 118 where a sample fluid may come in contact with the nanowires 106, 108, 110.
• Fig. 2 schematically illustrates a cross section view of the nanowires 106, 108, 110.
• Each nanowire has a thickness (vertical in the plane of drawing) and a width (horizontal in the plane of drawing).
• the dimensions of the nanowires typically range from a few nanometers up to hundreds of nanometers.
• the nanowires are in turn covered by an insulating material 202, 204 206.
• the insulating material may typically be an oxide such as Si0 2 (thermally grown), Ti0 2 or AI 2 O 3 .
• Various rare earth-oxides such as Zr0 2 , Hf0 2 or the like may also be used.
• wires within the same device 100 may have different geometries as shown by the different widths of nanowires 106 and 108, and that nanowires having the same geometry may have different thickness of the insulating layer as illustrated by the nanowires 108 and 110 and the corresponding insulating layers 204 and 206.
• nanowires having different electrical characteristics can be formed.
• a device may typically comprise a large number of nanowires in each sample compartment, such as for example 2 to-50 nanowires or more. Preferably there are 20 to 50 nanowires.
• Different functionalization layers can be arranged on the anowires or the insulating layer of the different nanowires.
• the functionalization layers may for example be chemical layers such as APTES or metal based layers and oxides such as Ti0 2 , Zr0 2 or Hf0 2 .
• the different functionalization layers can have different dielectric constants to provide differetn capacitive coupling to the wires to implement the range differences, dielectric constants of different materials are widely tabulated in standard texts such as the Handbook of Chemistry and Physics and will not be mentioned here.
• the nano wires may be part of a manifold of different types of electrical devices in the device.
• electrical devcies include gated devices such as: Field effect based devices having a gate (MOSFET, EGFET) or wihtout a gate (CHEMFET, ISFET, ImmunoFET, HEMFET, ESFET or ENFET.
• the device can be a part of or can be a electrical device for gas or fluid purity monitoring. Such may be an air pollution monitoring device.
• the substance to be detected may be formaldehyde as that is very toxic to humans.
• the device can be a water qualtiy monitoring system.
• Such devices may have particle filters, or activated carbon filters to remove disturbing side substances from the fluid sample before determining the substance amount.
• FIG.3 schematically outlines the general steps for manufacturing a device according to various embodiments of the invention. Fig. 3 will be discussed with reference to the flowchart of Fig. 4 outlining the general processing steps.
• a SOI substrate comprising a silicon carrier layer 102, a buried oxide (BOX) layer 104 and a top silicon layer 302.
• step 404 a mask is formed and silicon nano wires and corresponding contact structures 304 are etched in the top silicon layer 302.
• a nano wire mask may for example be formed through photolithography, e-beam lithography or imprinting.
• Etching is followed by step 406 comprising deposition of an insulator layer 306.
• the deposition of an insulator layer may for example be preferable if underetching occurs such that the parts of the BOX layer 104 adjacent to or under the nano wires is damaged during etching of the nanowires. Thereby, any damages resulting from underetching can be repaired by the deposition of the insulator layer 306.
• a protective silicon nitride (SiN) layer 308 is deposited followed by the deposition and patterning of a resist mask 310 exposing the nanowires.
• the SiN 308 and the insulator layer 306 is removed at the location of the openings in the mask 310 in the regions where the nanowires are located so as to expose the nanowires.
• the resist mask 310 is removed and in the final step 416, a thermal oxide 310 is grown on the nanowires to form an insulating layer on the nano wire.
• the thickness and properties of the grown thermal oxide can be controlled by controlling process parameters such as time, temperature and pressure.
• the steps 410 to 416 may be repeated for the same device in a way so that different nanowires or subsets of nanowires are exposed by different resist masks, which in turn make s it possible to form nanowires having grown oxide layers 312 of different thicknesses or different properties.
• the growth of a thermal oxide also makes it possible to control the geometry of the nanowire in by controlling the growth time.
• an oxide may be deposited in step 416, thereby increasing the flexibility in choice of insulating material. Deposition may for example be performed by CVD, ALD, sputtering or other known deposition methods. Thereby, by protecting different wires by different masks, nanowires having different insulating materials and different thickness of the insulating layer can be formed.
• various functionalizations of the nanowires may also be performed in step 416 by depositing functionalization layers such that a device capable of detecting a wide range of substances can be formed.
• Nanowires with different length and/or width can be advantageously made in one set of steps as these are determined by mask dimensions and do not require repeated exposure of different sets of nanowires for depositions etc.
• nanowires having different widths may be formed in step 404. Thereby, after performing the remaining steps as described above, nanowires of different width but with the same insulator material and insulator thickness are provided.
• Electrical contacts to the contacting structures are also formed and an ohmic contact is formed on the backside of the substrate to form a backside gate contact.
• a reference transistor is readily realizable on the same chip as a complement to the measurement device to enable differential measurements so that for example temperature changes and other environmental variations can be accounted for.
• the current vs. voltage characteristic for each of the nanowires in a device is determined for a constant gate voltage.
• Current saturation in a nanowire may for example occur if the conducting channel is saturated, i.e. if the conductive channel is completely closed or completely open. Saturation may also occur as a result of surface saturation, i.e. if the entire surface of the nanowire is covered by a substance.
• Current saturation can for example be determined by comparing the resulting measured characteristic with previously established reference values.
• the nanowire having the highest sensitivity is selected.
• the nanowire having the highest sensitivity is the nanowire able to detect the smallest change in concentration of the particular substance.
• the sensitivity of each of the nanowires is assumed to be known from manufacturing and/or from earlier calibrations of devices having the same layout.
• the method described above is performed for each subset of nanowires adapted to detect a respective substance.
• a C0 2 sensor can be formed by coating the nanowires with a thin (approximately lnm) layer of Ti0 2 .
• C0 2 has zero dipole moment, it will not induce an electrical field in the channel if attaching to the an insulating layer comprising for example Si0 2 . Therefore, Ti0 2 can be used which is known to decompose C0 2 into CO and 0 2 , which is polar and thereby induces a field in the conducting channel of the device.
• oxides such as Ti0 2 , Zr0 2 and Hf0 2 tend to be hydrophilic, thus adsorbing water molecules on the surface which will affect adsorption of C0 2 , and subsequently affect the electrical measurement. Therefore, in order to increase selectivity and to reduce the interference from adsorbed water, a hydrophobic layer which is permeable to C0 2 but not to water molecules may be deposited on the insulating layer.
• the hydrophobic layer may for example be a polymer such as parylene.
• the transient behavior of the device can be analyzed by applying a constant voltage to the source, drain and gate terminals and observing the time dependency of the measured current. Thereby, the concentration of one or more substances in a fluid under analysis can be determined.
• a fluidic reference gate for biasing the sample fluid may also be incorporated if it is required for a particular application.

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