WO2014054509A1 - 歯磨剤組成物及び歯の再石灰化促進剤 - Google Patents
歯磨剤組成物及び歯の再石灰化促進剤 Download PDFInfo
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- WO2014054509A1 WO2014054509A1 PCT/JP2013/076187 JP2013076187W WO2014054509A1 WO 2014054509 A1 WO2014054509 A1 WO 2014054509A1 JP 2013076187 W JP2013076187 W JP 2013076187W WO 2014054509 A1 WO2014054509 A1 WO 2014054509A1
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- component
- calcium carbonate
- dentifrice composition
- primary particle
- remineralization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Definitions
- the present invention relates to a dentifrice composition and a tooth remineralization accelerator that are excellent in promoting the recalcification of teeth, exhibit a high caries prevention effect, and have a good appearance stability of the preparation.
- Patent Document 1 defines the average primary particle size as 0.04 to 3 ⁇ m.
- the present invention has been made in view of the above circumstances, has a tooth remineralization promoting effect, has a high caries prevention effect, and has a good appearance stability of the preparation and tooth recalcification.
- An object is to provide a chemical accelerator.
- the present inventors have formulated (A) fine calcium carbonate having an average primary particle diameter of 1 ⁇ m or less and (B) an amphoteric surfactant in combination. It has been found that when the pH is 7 or more, it has an excellent effect on the promotion of tooth remineralization. Moreover, it discovered that it was excellent also in the external appearance stability of a formulation.
- the amphoteric surfactant of component (B), particularly fatty acid amidopropyl betaine acts specifically on component (A), and thus in the preparation of component (A). It is presumed that coagulation is suppressed, dispersibility is improved, calcium ion release properties into the oral cavity are increased, and the effect of promoting remineralization is improved.
- tooth remineralization means that the pH in the mouth is acidified by the acid produced in the plaque and the elution of minerals (Ca 2+ and HPO 4 2 ⁇ ) occurs, and then the pH is increased by the action of saliva etc. This is the action of tilting in the neutral direction, and once the mineral has melted, it returns to the inside of the tooth and restores the surface of the melted tooth.
- the recalcification of minerals is further promoted by the recalcification of minerals by the neutralization of acid and supplementation of calcium ions by the fine calcium carbonate of the component (A) reaching the details in the oral cavity. Is done.
- the combined use of the components (A) and (B) specifically enhances the effect of promoting remineralization of teeth, and is achieved by simply adding fine calcium carbonate and further adding a simple surfactant. Gives an exceptional effect that cannot be obtained.
- Patent Document 2 Japanese Patent Laid-Open No. 11-29454
- ultrafine calcium carbonate having a BET specific surface area in a specific range and an average primary particle size of 1 ⁇ m or less.
- the ultrafine calcium carbonate can specifically adhere to the plaque and improve remineralization, which is technically different from the present invention.
- the present invention comprises (A) fine calcium carbonate having an average primary particle size of 1 ⁇ m or less and (B) an amphoteric surfactant, and the pH of the composition is 7 or more.
- stimulates the remineralization of a tooth improves, and there exists a high caries prevention effect, Moreover, the dentifrice composition and the tooth
- the dentifrice composition of the present invention comprises (A) fine calcium carbonate having an average primary particle size of 1 ⁇ m or less, and (B) an amphoteric surfactant, and has a pH of 7 or more.
- the fine primary calcium carbonate (A) has an average primary particle size of 1 ⁇ m or less, preferably 0.04 to 1 ⁇ m, more preferably 0.04 to 0.5 ⁇ m.
- the average primary particle diameter exceeds 1 ⁇ m, the effectiveness decreases and a satisfactory remineralization promoting effect cannot be obtained.
- a thing with an average primary particle diameter of less than 0.04 micrometer may be difficult to manufacture.
- the primary particle diameter is a value obtained by measuring the particle size with an electron microscope, and the measurement method is as follows (the same applies hereinafter). Disperse the particles in water, further irradiate with ultrasonic waves for several minutes to highly disperse, drop a small amount of this dispersion onto a holder for electron microscope observation, dry it, and finally evaporate it for electron microscope observation It was.
- the particle diameter only particles that could be recognized as primary particles from four different visual fields were selected (25 particles per visual field) and measured.
- the particles were indefinite, the square root of the product of the longest diameter and the shortest diameter was taken as the primary particle diameter. A total of 100 primary particle sizes were averaged as the average particle size of the primary particles.
- fine calcium carbonate as the component (A), those having 50% by mass or more, especially 90% by mass or more of particles having a primary particle size of 0.04 to 0.5 ⁇ m as the primary particle size are remineralized. This is more preferable from the viewpoint of effectiveness of the promoting effect.
- the fine calcium carbonate releases free calcium ions and suppresses dissolution of minerals (calcium apatite), and at the same time promotes remineralization (mineral re-deposition).
- the average primary particle size exceeds 1 ⁇ m, and most is 3 to 30 ⁇ m.
- particles having a primary particle diameter of 0.5 ⁇ m or less are contained in an amount of about 1 to 3% by mass, but such calcium carbonate does not have an effect of promoting remineralization.
- fine calcium carbonate light calcium carbonate can be suitably used from the viewpoint of the production method such as easy control of the particle size distribution.
- the fine calcium carbonate as the component (A) for example, commercially available products such as trade names Calessen-A, Corocarso-EX, Corocarso-MG manufactured by Shiroishi Calcium Co., Ltd. can be used.
- the amount of component (A) is preferably 0.1 to 10% (mass%, the same applies hereinafter) of the total composition, more preferably 0.5 to 10%, still more preferably 0.5 to 3%. .
- the effect of promoting remineralization increases as the blending amount increases, but if it is 10% or less, the effect of dispersing the component (B) by the amphoteric surfactant can be satisfactorily exhibited and the appearance of the preparation is stably maintained. It is preferable because it is possible.
- betaine type surfactants are preferable, for example, fatty acid amide propyl betaines such as coconut oil fatty acid amide propyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazoli.
- alkyl imidazolinium betaines such as nium betaine, alkyl betaines, and the like, and one or more thereof can be used.
- fatty acid amidopropyl betaine, alkyl imidazolinium betaine, especially coconut oil fatty acid amidopropyl betaine, which has a particularly high remineralization promoting effect and weak taste can be suitably used.
- coconut oil fatty acid amidopropyl betaine coconut oil fatty acid contains lauric acid, myristic acid, etc., and the components and ratio of fatty acids are indicated in the commentary on cosmetic raw material standards, and component (B) is a quasi-drug. Those described in the raw material specifications can be used.
- amphoteric surfactants can be used.
- betaine-type amphoteric surfactants include coconut oil fatty acid amidopropyl betaine under the trade name TEGO Betaine CK OK (manufactured by EVONIK), and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine. C-40H (manufactured by Lion Corporation) and the like.
- the blending amount of component (B) is preferably 0.1 to 5% of the total composition, more preferably 0.2 to 5%, still more preferably 0.5 to 5%, especially 0.5 to 2.5%. Is preferred. The greater the amount, the higher the remineralization promoting effect, and 0.1% or more is preferable for effect expression, and 5% or less maintains the appearance stability of the preparation. Is preferable.
- the blending ratio of the component (A) to the component (B) is preferably 0.02 to 30, more preferably 0.05 to 25, and still more preferably 0.00 as the mass ratio of the component (A) / component (B). 2 to 20, particularly 0.2 to 5 is preferred.
- the blending ratio is within the above range, the effect of promoting remineralization is further enhanced and the appearance stability of the preparation is also excellent.
- the pH (25 ° C.) of the dentifrice composition of the present invention is 7 or more, and is preferably 7 to 10, more preferably 7 to 9, from the viewpoint of remineralization promoting effect and formulation stability.
- the pH is 7 or more, the combined system of the components (A) and (B) is excellent in the remineralization promoting effect.
- the pH is less than 7, the effect of promoting remineralization by the combined system is not exhibited.
- the fine calcium carbonate of component (A) dissolves in the preparation and calcium ions are eluted, resulting in poor preparation stability.
- the pH of the composition becomes 7 or more depending on the situation, but it may be adjusted to an appropriate pH using a pH adjusting agent such as sodium hydroxide or potassium hydroxide as necessary.
- the dentifrice composition of the present invention preferably further contains a fluorine compound.
- a fluorine compound When a fluorine compound is added, the decalcification inhibitory effect of the teeth is improved and the caries prevention effect is further enhanced. it can.
- Fluorine compounds include soluble fluorides such as alkali fluorides such as sodium fluoride, ammonium fluoride, and potassium fluoride, and monofluorophosphates such as sodium monofluorophosphate, ammonium monofluorophosphate, and potassium monofluorophosphate. Compounds.
- the blending amount is preferably 400 to 1,500 ppm, particularly 500 to 1,000 ppm as fluorine ions with respect to the entire composition.
- the amount of 1,500 ppm or less is suitable for maintaining good formulation stability.
- the dentifrice composition of the present invention is suitably prepared as a toothpaste, a liquid dentifrice or the like, particularly as a toothpaste.
- the well-known component normally used besides the said component can be mix
- abrasives, thickeners, binders, surfactants, fragrances, sweeteners, preservatives, colorants, active ingredients other than those described above, etc. are used in normal amounts within a range that does not interfere with the effects of the present invention. Can do.
- polishing agents silica-based polishing such as silica carbonate, precipitated silica, aluminosilicate, zirconosilicate, etc., as well as conventionally used calcium carbonate for polishing with an average primary particle diameter exceeding 1 ⁇ m, especially about 3-30 ⁇ m.
- the average primary particle size of the abrasive is a value obtained by measurement with an electron microscope in the same manner as described above.
- the blending amount of the abrasive is usually 5 to 50%, particularly 10 to 30% of the whole composition.
- thickener examples include sugar alcohols such as sorbit, xylit, malt, and lactit, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol.
- sugar alcohols such as sorbit, xylit, malt, and lactit
- polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol.
- the amount of these thickeners is usually 5 to 50% of the total composition.
- binder examples include xanthan gum, sodium carboxymethyl cellulose, hydroxyethyl cellulose, carrageenan, sodium polyacrylate, and thickening silica.
- the amount of the binder is usually 0 to 5%, particularly 0.1 to 5% of the total composition.
- an anionic surfactant As the surfactant, an anionic surfactant, a nonionic surfactant, and a cationic surfactant can be blended.
- the anionic surfactant include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine and sodium N-myristoyl sarcosine, and sodium ⁇ -olefin sulfonate.
- Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol Ether type or ester type surfactants such as fatty acid ester polyhydric alcohol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, polyoxyethylene hydrogenated castor oil, etc. And fatty acid alkanolamides such as lauric acid diethanolamide.
- Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts.
- the blending amount of these surfactants is preferably 0.5 to 5% of the total composition as long as the effects of the present invention are not hindered.
- Sweeteners include saccharin sodium and the like, and antiseptics include paraoxybenzoic acid esters and sodium benzoate. Examples of the colorant include blue No. 1, yellow No. 4, and the like.
- Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Fragrance, etc.), menthol, coffee Bonn, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Mentoxypropan
- enzymes such as dextranase and mutanase, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphate, isopropylmethylphenol, tranexamic acid, epsilon-aminocaproic acid, Allantochlorohydroxyaluminum, hinokitiol, ascorbic acid, dl-tocopherol acetate, dihydrocholesterol, ⁇ -bisabolol, chlorhexidine salts, azulene, glycyrrhizin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, glycerophosphate, copper gluconate, aluminum lactate, strontium chloride , Potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, methoxyethylene, maleic anhydride Copoly
- water-soluble phosphate compounds such as potassium salt and sodium
- Plant extracts can be blended.
- the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.
- purified water is blended as a solvent, and the amount of water in the composition may be a normal amount.
- the present invention provides a tooth remineralization accelerator comprising (A) fine calcium carbonate having an average primary particle diameter of 1 ⁇ m or less and (B) an amphoteric surfactant, and having a pH of 7 or more.
- the component (A) / component (B) is preferably 0.02 to 30 in terms of mass ratio, and within this range, the remineralization promoting effect is more excellent and the appearance stability of the preparation is also improved. Better.
- Toothpaste compositions having the compositions shown in Tables 1 and 2 were prepared by conventional methods, and the remineralization promoting effect and formulation stability were evaluated by the following methods. The results are shown in the table.
- the details of the raw materials used are as follows.
- the average primary particle diameter of the fine calcium carbonate is a value measured with an electron microscope in the same manner as described above.
- A fine calcium carbonate; Fine calcium carbonate (A-1); CoroCarso-EX (manufactured by Shiraishi Calcium Co., Ltd., average primary particle size of 0.25 ⁇ m, primary particle size of 50% or more of particles is in the range of 0.04 to 0.5 ⁇ m)
- B Coconut oil fatty acid amidopropyl betaine; TEGO Betaine CK OK (EVONIK)
- B 2-Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine
- Enacol C-40H manufactured by Lion Corporation
- Remineralization rate [%] ( ⁇ F ⁇ F 0 ) / ⁇ F 0 ⁇ 100 Evaluation standard of remineralization promoting effect ⁇ : Remineralization rate is 50% or more ⁇ : Remineralization rate is 30% or more and less than 50% ⁇ : Remineralization rate is 20% or more and less than 30% ⁇ : Remineralization rate Is less than 20%
Abstract
Description
更に詳述すると、微細炭酸カルシウムは、歯磨剤組成物中で他の配合成分、例えば研磨剤、水などの影響で凝集し易く、一旦凝集すると、再分散させることが困難となり、口腔内で分解し難くなるという課題が生じるが、本発明においては、(A)成分に(B)成分の両性界面活性剤、特に脂肪酸アミドプロピルベタインが特異的に作用し、これにより(A)成分の製剤中での凝集が抑制されて分散性が向上し、かつ口腔内へのカルシウムイオン放出性が高まり、再石灰化促進効果が向上すると推測される。また、製剤中で微細炭酸カルシウムが分解してカルシウムイオンが放出されると、経時において練り肌等の製剤外観に課題が生じるが、本発明によれば、口腔内でのカルシウムイオンの放出性は高まるが、製剤中での微細炭酸カルシウムの分解は抑えられ、製剤外観を安定に維持することもできる。
一般に歯の再石灰化とは、歯垢内で産生された酸により口内のpHが酸性に傾いてミネラル(Ca2+とHPO4 2-)の溶出が生じた後、唾液等の作用によりpHが中性方向に傾き、一度溶け出したミネラルが再び歯の内部に戻って、溶かされた歯の表層下を修復する作用のことである。本発明では、(A)成分の微細炭酸カルシウムが口腔内の細部にまで行き渡ることで、酸の中和及びカルシウムイオンの補給によりミネラルの再沈着が進み、再石灰化がより促進されると推測される。
このように本発明では、(A)、(B)成分の併用によって特異的に歯の再石灰化促進効果が増強し、単なる微細炭酸カルシウムの配合、更には単なる界面活性剤の添加では達成し得ない格別顕著な作用効果を与える。
粒子を水に分散し、更に超音波を数分間照射して高度に分散させ、この分散液を電子顕微鏡観察用の保持台に少量滴下して乾燥させ、最後に蒸着して電子顕微鏡観察を行った。粒子径の計測には、異なった4つの視野から一次粒子と認めることができる粒子のみを選択して(1視野あたり25個)計測した。粒子が不定形の場合は、最長径と最短径の積の平方根を一次粒子径とした。
合計100個の一次粒子径を平均したものを一次粒子の平均粒子径とした。
(A)成分の微細炭酸カルシウムとしては、例えば白石カルシウム(株)製の商品名 カルエッセン-A、コロカルソ-EX、コロカルソ-MG等の市販品を使用できる。
フッ素化合物としては、フッ化ナトリウム、フッ化アンモニウム、フッ化カリウム等のアルカリフッ化物、モノフルオロリン酸ナトリウム、モノフルオロリン酸アンモニウム、モノフルオロリン酸カリウム等のモノフルオロリン酸塩などの可溶性フッ素化合物が挙げられる。
研磨剤の配合量は通常、組成全体の5~50%、特に10~30%である。
非イオン性界面活性剤としては、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ショ糖脂肪酸エステル等の糖アルコール脂肪酸エステル類、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリエチレングリコール脂肪酸エステル等の多価アルコール脂肪酸エステル、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンポリオキシプロピレン共重合体、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレン硬化ヒマシ油等のエーテル型又はエステル型の界面活性剤、ラウリン酸ジエタノールアミド等の脂肪酸アルカノールアミドなどが挙げられる。
カチオン性界面活性剤としては、アルキルアンモニウム、アルキルベンジルアンモニウム塩等が挙げられる。
これら界面活性剤の配合量は、本発明の効果を妨げない範囲で、組成全体の0.5~5%が好ましい。
なお、本発明組成物は、溶剤として精製水が配合され、組成中の水分量は通常量でよい。
なお、配合成分、その配合量、配合比率、pH等の詳細については、いずれも歯磨剤組成物にかかわる上記記載と同様である。
表1、2に示す組成の練歯磨剤組成物を常法により調製し、下記方法で再石灰化促進効果、製剤安定性を評価した。結果を表に併記する。
(A)微細炭酸カルシウム;
微細炭酸カルシウム(A-1);コロカルソ-EX(白石カルシウム(株)製、平均一次粒子径0.25μm、50%以上の粒子の一次粒子径は0.04~0.5μmの範囲内。)
微細炭酸カルシウム(A-2);カルエッセン-A(白石カルシウム(株)製、平均一次粒子径0.07μm、50%以上の粒子の一次粒子径は0.04~0.5μmの範囲内。)
(B)ヤシ油脂肪酸アミドプロピルベタイン;TEGO Betain CK OK(EVONIK社製)
(B)2-アルキル-N-カルボキシメチル-N-ヒドロキシエチルイミダゾリニウムベタイン;エナジコールC-40H(ライオン(株)製)
無水ケイ酸;ローディア社製のシリカ系研磨剤
ヒト臼歯の歯ブロックをpH4.5の脱灰液に浸漬して初期う蝕サンプルを作製した。QLF(Quantitative Light-induced Fluoresence)を用いて、初期平均脱灰深さΔF0値を測定した。この歯ブロックを用いて、歯磨剤組成物の3倍希釈液で3分間処置→水洗浄→人工唾液(pH6.0、37℃)を2週間繰り返し行った。その後、QLFを用いて歯ブロックの平均脱灰深さΔF値を測定し、下記の計算方法にて再石灰化率を算出し、下記基準にて評価を行った。
再石灰化率[%]=(ΔF-ΔF0)/ΔF0×100
再石灰化促進効果の評価基準
◎:再石灰化率が50%以上
○:再石灰化率が30%以上50%未満
△:再石灰化率が20%以上30%未満
×:再石灰化率が20%未満
調製した歯磨剤組成物をラミネートチューブに充填し、それぞれ5本ずつを40℃で1ヶ月間保存した。その後、常温に戻した歯磨剤組成物を歯ブラシの上にのせ、その外観を観察し、下記基準にて評価を行った。
製剤安定性(外観)の評点基準
4:表面状態にツヤがあり,ツブやシワなどが無く、なめらかである
3:表面状態はツブやシワなどがわずかに認められるが、なめらかであ
る
2:表面状態にツブ又はシワが認められ、ペーストの均一性がない状態
である
1:押し出したときのペースト状態に著しくツブ又はシワが認められ、
不均一でペーストの連続性がない状態である
製剤安定性(外観)の評価基準
◎:4.0点
○:3.0点以上4.0点未満
△:2.0点以上3.0点未満
×:2.0点未満
Claims (13)
- (A)平均一次粒子径が1μm以下である微細炭酸カルシウムと、(B)両性界面活性剤とを含有してなり、組成物のpHが7以上であることを特徴とする歯磨剤組成物。
- (A)成分/(B)成分が質量比として0.02~30である請求項1記載の歯磨剤組成物。
- (A)成分を0.1~10質量%、(B)成分を0.1~5質量%含有する請求項1又は2記載の歯磨剤組成物。
- (A)成分の微細炭酸カルシウムが、50質量%以上の粒子の一次粒子径が0.04~0.5μmの範囲内である請求項1、2又は3記載の歯磨剤組成物。
- (B)成分が脂肪酸アミドプロピルベタインである請求項1乃至4のいずれか1項記載の歯磨剤組成物。
- (B)成分がヤシ油脂肪酸アミドプロピルベタインである請求項5記載の歯磨剤組成物。
- 組成物のpHが7~10である請求項1乃至6のいずれか1項記載の歯磨剤組成物。
- 更に、フッ素化合物をフッ素イオンとして400~1,500ppm含有する請求項1乃至7のいずれか1項記載の歯磨剤組成物。
- 更に、研磨剤を5~50質量%、粘稠剤を5~50質量%、粘結剤を0~5質量%、アニオン性界面活性剤,非イオン性界面活性剤及びカチオン性界面活性剤から選ばれる界面活性剤を0.5~5質量%含有する練歯磨剤組成物である請求項1乃至8のいずれか1項記載の歯磨剤組成物。
- (A)平均一次粒子径が1μm以下である微細炭酸カルシウムと、(B)両性界面活性剤とからなり、pHが7以上である歯の再石灰化促進剤。
- (A)成分/(B)成分が質量比として0.02~30である請求項10記載の歯の再石灰化促進剤。
- (A)成分の微細炭酸カルシウムが、50質量%以上の粒子の一次粒子径が0.04~0.5μmの範囲内である請求項10又は11記載の歯の再石灰化促進剤。
- pHが7~10である請求項10、11又は12記載の歯の再石灰化促進剤。
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MYPI2015000774A MY181839A (en) | 2012-10-01 | 2013-09-27 | Dentifrice composition, and tooth recalcification promoter |
JP2014539692A JP6264292B2 (ja) | 2012-10-01 | 2013-09-27 | 歯磨剤組成物及び歯の再石灰化促進剤 |
CN201380047705.2A CN104717955B (zh) | 2012-10-01 | 2013-09-27 | 洁齿剂组合物以及牙齿再矿化促进剂 |
KR1020157003687A KR102102130B1 (ko) | 2012-10-01 | 2013-09-27 | 치마제 조성물 및 치아의 재석회화 촉진제 |
PH12015500711A PH12015500711B1 (en) | 2012-10-01 | 2015-03-30 | Dentifrice composition, and tooth recalcification promoter |
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KR (1) | KR102102130B1 (ja) |
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JP2007169234A (ja) * | 2005-12-26 | 2007-07-05 | Lion Corp | 歯磨組成物 |
JP2008007479A (ja) * | 2006-06-30 | 2008-01-17 | Lion Corp | 口腔用組成物及び炭酸カルシウム被覆水難溶性薬効成分微粒子の糖アルコール水溶液分散液の製造方法 |
JP2008063291A (ja) * | 2006-09-08 | 2008-03-21 | Lion Corp | 薬効成分複合化微粒子水分散液およびその製造方法、並びに口腔用組成物 |
JP2010111648A (ja) * | 2008-11-10 | 2010-05-20 | Lion Corp | 歯磨剤組成物 |
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JPH09295924A (ja) * | 1996-04-30 | 1997-11-18 | Lion Corp | 歯垢の酸中和剤及び口腔用組成物 |
JPH1129454A (ja) | 1997-07-04 | 1999-02-02 | Lion Corp | 口腔用組成物 |
JPH11130643A (ja) * | 1997-10-28 | 1999-05-18 | Lion Corp | 口腔用組成物 |
KR101234172B1 (ko) * | 2005-11-25 | 2013-02-19 | "더블유디에스"컴퍼니 | 구강 치료 및 예방 조성물 |
BRPI0821860B1 (pt) * | 2008-02-08 | 2016-11-01 | Colgate Palmolive Co | composição para cuidado oral, e, usos de uma composição e de um aminoácido básico, em forma livre ou de sal |
JP5368015B2 (ja) * | 2008-06-25 | 2013-12-18 | ユニチカ株式会社 | 再石灰化促進剤 |
TWI404544B (zh) * | 2008-08-11 | 2013-08-11 | Colgate Palmolive Co | 含珠粒之口腔保健組成物 |
JP5625647B2 (ja) * | 2010-09-08 | 2014-11-19 | ライオン株式会社 | 歯磨組成物 |
JP5682235B2 (ja) * | 2010-11-05 | 2015-03-11 | ライオン株式会社 | 歯磨組成物及び歯磨組成物の泡性能及び油溶性成分の口内滞留性を改善する方法 |
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- 2013-09-27 KR KR1020157003687A patent/KR102102130B1/ko active IP Right Grant
- 2013-09-27 JP JP2014539692A patent/JP6264292B2/ja active Active
- 2013-09-27 CN CN201380047705.2A patent/CN104717955B/zh active Active
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JP2007169234A (ja) * | 2005-12-26 | 2007-07-05 | Lion Corp | 歯磨組成物 |
JP2008007479A (ja) * | 2006-06-30 | 2008-01-17 | Lion Corp | 口腔用組成物及び炭酸カルシウム被覆水難溶性薬効成分微粒子の糖アルコール水溶液分散液の製造方法 |
JP2008063291A (ja) * | 2006-09-08 | 2008-03-21 | Lion Corp | 薬効成分複合化微粒子水分散液およびその製造方法、並びに口腔用組成物 |
JP2010111648A (ja) * | 2008-11-10 | 2010-05-20 | Lion Corp | 歯磨剤組成物 |
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KR20150061631A (ko) | 2015-06-04 |
JPWO2014054509A1 (ja) | 2016-08-25 |
PH12015500711A1 (en) | 2015-05-18 |
CN104717955B (zh) | 2018-04-27 |
PH12015500711B1 (en) | 2015-05-18 |
CN104717955A (zh) | 2015-06-17 |
JP6264292B2 (ja) | 2018-01-24 |
MY181839A (en) | 2021-01-08 |
KR102102130B1 (ko) | 2020-04-20 |
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