WO2013081331A1 - 방부력이 우수한 피부 외용제 조성물 - Google Patents
방부력이 우수한 피부 외용제 조성물 Download PDFInfo
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- WO2013081331A1 WO2013081331A1 PCT/KR2012/009945 KR2012009945W WO2013081331A1 WO 2013081331 A1 WO2013081331 A1 WO 2013081331A1 KR 2012009945 W KR2012009945 W KR 2012009945W WO 2013081331 A1 WO2013081331 A1 WO 2013081331A1
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- skin
- glyceryl
- citrus
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- preparation composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
Definitions
- the present invention relates to an external preparation composition for skin having excellent antiseptic power without using a chemical preservative, and more particularly, to glyceryl undecylenate having excellent antiseptic power; And at least one mixture selected from the group consisting of ethylhexylglycerin, glyceryl caprylate, p-anisic acid, and citrus mixed extract, thereby providing a skin external preparation composition having excellent antiseptic properties through synergistic effects on antiseptic properties of these substances. It is about.
- the external preparation composition for skin is contaminated by microorganisms adhered to the manufacturing plant, in the manufacturing water or the raw material conveying pipe, or in contact with the skin of the user's finger, palm, face, etc., or by bacteria on the surface of the product container. Incorporation of heavy foreign substances can contaminate microorganisms. For this reason, paraoxybenzoic acid esters (parabens), imidazolidinyl urea, phenoxyethanol, chlorophenesin for the purpose of inhibiting the growth of contaminated microorganisms and improving the antiseptic ability to kill contaminated microorganisms in the external preparation composition. And preservatives such as benzoic acid, sorbic acid and dehydroacetic acid are blended.
- a method for preparing an external preparation composition for skin without using a conventional chemical preservative using diols, which are known to have antimicrobial activity, or packaging them in a container that prevents microbial incorporation and suppresses microbial contamination during the manufacturing process For example, it is possible to prepare external preparations that do not use preservatives or have less preservatives than normal levels.However, in the case of diols, skin irritation affects safety, solubilization, and stability of emulsion formulations. The use of a container that suppresses the influx of bacteria leads to a lack of economic versatility due to the complicated manufacturing process and the increase of equipment maintenance cost and container cost.
- the present inventors have attempted to provide a skin external preparation composition having a safe antiseptic power from harmful microorganisms introduced at least equal to a skin external preparation composition using a chemical preservative without using a conventional chemical preservative.
- the present invention has been completed by discovering that when used in combination with glycerin, glyceryl caprylate, p-anisic acid or citrus mixed extract, it can provide excellent antiseptic properties due to the synergistic effect on the antiseptic properties of these materials.
- an object of the present invention is to provide an external composition for skin having excellent antiseptic power without using a conventional chemical preservative.
- the present invention is glyceryl undecylenate; And at least one selected from the group consisting of ethylhexyl glycerine, glyceryl caprylate, p-anisic acid and citrus mixed extract.
- the present invention provides an antiseptic power equivalent to that of using a chemical preservative without using a conventional chemical preservative, and does not cause toxicity, skin irritation, irritation and allergy due to the use of the chemical preservative, and can be used safely on the skin. Can be.
- 1 is a flowchart showing a procedure for evaluating antiseptic force.
- the present invention is glyceryl undecylenate; And it relates to an external composition for skin having excellent antiseptic power by combining and using at least one mixture selected from the group consisting of ethylhexyl glycerine, glyceryl caprylate, p- anisic acid and citrus mixed extract.
- the composition of the present invention is 0.01 to 4.0% by weight of glyceryl undecylenate, 0.01 to 1.0% by weight of ethylhexylglycerin, 0.01 to 1.0% by weight of glyceryl caprylate, 0.01-1.0 wt% of p-anis acid and 0.01-1.0 wt% of citrus mixed extract are used.
- the citrus mixed extract used in the present invention is not limited to citrus plants usable as extracts of citrus plants, but extracts such as grapefruit, bergamot, sweet orange, tangerine, mandarin orange, or mixtures thereof may be used. Extracts from all parts of citrus fruits such as stems, leaves, flowers and fruits can be used, and are not limited to extracts of any particular part.
- the extract includes not only the leaching liquid obtained by leaching and transferring from citrus plants, but also all of the concentrates obtained by partially or totally concentrating the leaching liquid or those prepared by drying the above concentrate again, preferably the extract prepared as described above. Used in combination with vegetable glycerin.
- the extract in the present invention, the fruit, leaves, stems, etc. of the citrus plants are compressed and then fermented by mixing, the fermentation products are centrifuged to take a liquid fermentation extract, and then heat treated and mixed with vegetable glycerin It is desirable to.
- the present invention provides a chemical preservative such as parabens and phenoxyethanol, skin irritation or irritation. It is possible to provide an external composition for skin having sufficient antiseptic power without compounding existing diols which may be induced.
- the citrus mixed extract used Bio Citro liquid (Quinabra) product
- the product is grapefruit (Citrus Paradisi) fruit extract, bergamot (Citrus Aurantium Bergamia) fruit extract, orange (Citrus Aurantium Dulcis) fruit extract, Tangerine (Citrus) Tangerina) fruit extract and glycerin.
- Comparative Example 2 in which glyceryl undecylate and ethylhexylglycerine glyceryl caprylate, p-anisic acid, and citrus mixed extract were used, respectively. It can be observed that even with the use of less than ⁇ 6, there is a better antiseptic ability, the use of less amount compared to the case of Comparative Example 7 using the conventional preservatives methylparaben, propylparaben and phenoxyethanol It can be seen that also shows an excellent degree of antiseptic force.
- Example 1 The skin external composition of Examples 1 to 4 according to the present invention was compared with Comparative Example 1 in subjects sensitive to irritation such as stinging, burning, and the like of 15 panelists, which were compared with Comparative Example 1, Example 1, and Comparative Example 1 0.5 ml each of the test samples of Example 2, Comparative Example 1 and Example 3, Comparative Example 1 and Example 4 was randomly applied to the left and right to rub and evaluate irritation such as stinging, itching and eye irritation. Table 4 shows.
- Example 4 the irritation of the product using glyceryl undecylate and ethyl hexyl glycerine, glyceryl caprylate, p-anisic acid or citrus mixed extract was non-irritating and compared with the above substances. Compared with Example 1 did not show a significant difference in the sense of irritation can be seen that there is no increase in irritation due to the material used in the present invention.
- a patch test was conducted on 40 subjects for 24 hours to evaluate the skin safety of the glyceryl undecylate, ethylhexylglycerine, glyceryl caprylate, p-anisic acid and citrus mixed extract in the human body.
- the patch was attached to the back of the subject, and 20 ⁇ l of the prepared test substance was patched using an IQ chamber (chemotechique, Sweeden). After 24 hours, the patch was removed, and then the first reading was made 30 minutes later, and after 24 hours, a second reading was made.
- weights were assigned according to the degree of positive reaction of the skin, and the average skin reactivity was determined according to Equation 1 below to determine skin irritation of the sample.
- Test substance score Glyceryl Undecylenate 4% 0.00 Ethylsilyl Glycerin 3% 0.31 Glyceryl Caprylate 5% 0.94 p-anisic acid 1% 0.94 Citrus Mixed Extract 1% 0.00
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Abstract
Description
원료명 | 실시예 | 비교예 | |||||||||
1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | |
정제수 | 잔량 | 잔량 | 잔량 | 잔량 | 잔량 | 잔량 | 잔량 | 잔량 | 잔량 | 잔량 | 잔량 |
사이클로펜타실록산 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 | 3.00 |
디프로필렌글라이콜 | 2.50 | 2.50 | 2.50 | 2.50 | 2.50 | 2.50 | 2.50 | 2.50 | 2.50 | 2.50 | 2.50 |
디메치콘/비닐디메치콘크로스폴리머 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 |
하이드롤라이즈드밀단백질/피브이피크로스폴리머 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 | 2.00 |
베타-글루칸 | 1.30 | 1.30 | 1.30 | 1.30 | 1.30 | 1.30 | 1.30 | 1.30 | 1.30 | 1.30 | 1.30 |
피이지-100스테아레이트 | 1.20 | 1.20 | 1.20 | 1.20 | 1.20 | 1.20 | 1.20 | 1.20 | 1.20 | 1.20 | 1.20 |
세틸에칠헥사노에이트 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
디메치콘 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
세테아릴알코올 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 |
실리카 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 | 0.50 |
암모늄아크릴로일디메칠타우레이트/브이피코폴리머 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 | 0.40 |
소르비탄세스퀴올리에이트 | 0.30 | 0.30 | 0.30 | 0.30 | 0.30 | 0.30 | 0.30 | 0.30 | 0.30 | 0.30 | 0.30 |
카보머 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 | 0.15 |
트리에탄올아민 | 0.14 | 0.14 | 0.14 | 0.14 | 0.14 | 0.14 | 0.14 | 0.14 | 0.14 | 0.14 | 0.14 |
디소듐이디티에이 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 |
색소 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 |
향료 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 | 적량 |
글리세릴 운데실리네이트 | 0.5 | 0.5 | 0.5 | 0.5 | 1.00 | ||||||
에칠헥실글리세린 | 0.1 | 0.2 | |||||||||
글리세릴 카프릴레이트 | 0.2 | 0.4 | |||||||||
p-아니스산 | 0.2 | 0.4 | |||||||||
시트러스 혼합 추출물 | 0.2 | 0.4 | |||||||||
메칠파라벤 | 0.25 | ||||||||||
프로필파라벤 | 0.1 | ||||||||||
페녹시에탄올 | 0.4 |
화장료 | 박테리아(cfu/g) | ||||
초기균수 | 7일차 | 14일차 | 28일차 | ||
로션 | 실시예 1 | 5×105 | <1×103 | < 1×102 | <1×102 |
실시예 2 | 5×105 | <1×103 | < 1×102 | <1×102 | |
실시예 3 | 5×105 | <1×103 | < 1×102 | <1×102 | |
실시예 4 | 5×105 | <1×103 | < 1×102 | <1×102 | |
비교예 1 | 5×105 | >1×106 | >1×106 | >1×106 | |
비교예 2 | 5×105 | 5×105 | 3.1×103 | 1×103 | |
비교예 3 | 5×105 | 4.5×105 | 1×105 | 2×103 | |
비교예 4 | 5×105 | 3.5×105 | 1×105 | 3×104 | |
비교예 5 | 5×105 | 3.5×105 | 1×105 | 1×104 | |
비교예 6 | 5×105 | 4×105 | 4×105 | 4×105 | |
비교예 7 | 5×105 | <1×103 | < 1×102 | <1×102 |
화장료 | 곰팡이(cfu/g) | |||||
초기균수 | 7일차 | 14일차 | 28일차 | 육안관찰 | ||
로션 | 실시예 1 | 1×105 | 1×104 | 2×102 | 1×102 | 이상없음 |
실시예 2 | 1×105 | 1×104 | 2×103 | 1×103 | 이상없음 | |
실시예 3 | 1×105 | 1×104 | 1×103 | 1×102 | 이상없음 | |
실시예 4 | 1×105 | 1×104 | 1×103 | 1×103 | 이상없음 | |
비교예 1 | 1×105 | 1×105 | 1×105 | 1×105 | 포자발생 | |
비교예 2 | 1×105 | 2.3×104 | 3.6×104 | 1×103 | 이상없음 | |
비교예 3 | 1×105 | 3×104 | 2.1×104 | 1×103 | 이상없음 | |
비교예 4 | 1×105 | 3×104 | 2.1×104 | 1×103 | 이상없음 | |
비교예 5 | 1×105 | 1×103 | 1×102 | 1×102 | 이상없음 | |
비교예 6 | 1×105 | 1×105 | 1×105 | 1×105 | 포자발생 | |
비교예 7 | 1×105 | 1×104 | 2×103 | 1×103 | 이상없음 |
비교예1 | 실시예1 | 비교예1 | 실시예2 | 비교예1 | 실시예3 | 비교예1 | 실시예4 | |
따가움 | 0.09 | 0.11 | 0.46 | 0.27 | 0.06 | 0.16 | 0.20 | 0.19 |
화끈거림 | 0.20 | 0.35 | 0.16 | 0.34 | 0.49 | 0.29 | 0.42 | 0.35 |
평균 | 0.15 | 0.23 | 0.31 | 0.31 | 0.28 | 0.23 | 0.31 | 0.27 |
시험 물질 | 점수 |
글리세릴 운데실리네이트 4% | 0.00 |
에칠핵실글리세린 3% | 0.31 |
글리세릴 카프릴레이트 5% | 0.94 |
p-아니스산 1% | 0.94 |
시트러스 혼합 추출물 1% | 0.00 |
Claims (4)
- 글리세릴 운데실리네이트; 및 에칠헥실글리세린, 글리세릴카프릴레이트, p-아니스산 및 시트러스 혼합 추출물로 이루어진 군으로부터 선택된 1종 이상;을 함유하는 피부 외용제 조성물.
- 제1항에 있어서, 조성물 총 중량에 대하여 상기 글리세릴 운데실리네이트는 0.01~4.0중량%, 에칠헥실글리세린은 0.01~1.0중량%, 글리세릴카프릴레이트는 0.01~1.0중량%, p-아니스산은 0.01~1.0중량%, 시트러스 혼합 추출물은 0.01~1.0중량%의 양으로 함유되는 피부 외용제 조성물.
- 제1항에 있어서, 상기 조성물은 방부력이 향상됨을 특징으로 하는 피부 외용제 조성물.
- 글리세릴 운데실리네이트; 및 에칠헥실글리세린, 글리세릴카프릴레이트, p-아니스산 및 시트러스 혼합 추출물로 이루어진 군으로부터 선택된 1종 이상;의 혼합물의 방부제로서의 용도.
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JP2014543419A JP6073354B2 (ja) | 2011-11-28 | 2012-11-23 | 防腐力に優れた皮膚外用剤組成物 |
CN201280057068.2A CN103957901B (zh) | 2011-11-28 | 2012-11-23 | 具有优异的防腐能力的皮肤外用剂组合物 |
US14/359,933 US10172820B2 (en) | 2011-11-28 | 2012-11-23 | Skin preparation composition for external use having excellent antiseptic ability |
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KR1020110124895A KR101852487B1 (ko) | 2011-11-28 | 2011-11-28 | 방부력이 우수한 피부 외용제 조성물 |
KR10-2011-0124895 | 2011-11-28 |
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US (1) | US10172820B2 (ko) |
JP (1) | JP6073354B2 (ko) |
KR (1) | KR101852487B1 (ko) |
CN (1) | CN103957901B (ko) |
WO (1) | WO2013081331A1 (ko) |
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KR102102253B1 (ko) * | 2013-11-29 | 2020-04-22 | (주)아모레퍼시픽 | 방부력이 우수한 피부 외용제 조성물 |
FR3029740B1 (fr) * | 2014-12-10 | 2016-12-30 | Agronutrition | Composition antiseptique par contact et procede non therapeutique de traitement antiseptique par contact |
WO2016126059A1 (ko) * | 2015-02-04 | 2016-08-11 | 임호 | 항균조성물 및 상기 항균조성물을 포함한 물티슈 |
KR101632916B1 (ko) * | 2016-02-04 | 2016-06-23 | 충청남도 | 보리수나무 추출물을 포함하는 천연 방부제 조성물 |
KR20180082143A (ko) * | 2017-01-10 | 2018-07-18 | (주)아모레퍼시픽 | 헥사메타인산나트륨을 함유하는 화장료 조성물 |
WO2020256245A1 (ko) * | 2019-06-21 | 2020-12-24 | 주식회사 엑티브온 | 피부 외용제용 보존제, 이를 포함하는 화장료 조성물 및 약학 조성물 |
CN114404310B (zh) * | 2021-12-30 | 2023-05-23 | 原田(苏州)技术研发有限公司 | 含大红橘脂的防腐组合物 |
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JP4111257B2 (ja) * | 1999-08-02 | 2008-07-02 | 阪本薬品工業株式会社 | 化粧料組成物 |
JP2002114670A (ja) * | 2000-10-02 | 2002-04-16 | Noevir Co Ltd | 抗菌性皮膚外用剤 |
JP2004010598A (ja) * | 2002-06-11 | 2004-01-15 | Kuraray Co Ltd | 皮膚外用剤 |
JP2005082528A (ja) * | 2003-09-08 | 2005-03-31 | Ina Food Ind Co Ltd | 抗菌剤 |
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Publication number | Publication date |
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JP6073354B2 (ja) | 2017-02-01 |
CN103957901A (zh) | 2014-07-30 |
CN103957901B (zh) | 2017-09-05 |
US20140328953A1 (en) | 2014-11-06 |
KR101852487B1 (ko) | 2018-04-27 |
KR20130058901A (ko) | 2013-06-05 |
JP2014533725A (ja) | 2014-12-15 |
US10172820B2 (en) | 2019-01-08 |
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