WO2012091054A1 - リポソーム組成物およびその製造方法 - Google Patents

リポソーム組成物およびその製造方法 Download PDF

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Publication number
WO2012091054A1
WO2012091054A1 PCT/JP2011/080304 JP2011080304W WO2012091054A1 WO 2012091054 A1 WO2012091054 A1 WO 2012091054A1 JP 2011080304 W JP2011080304 W JP 2011080304W WO 2012091054 A1 WO2012091054 A1 WO 2012091054A1
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WO
WIPO (PCT)
Prior art keywords
liposome
drug
aqueous phase
gradient
solution
Prior art date
Application number
PCT/JP2011/080304
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
恵子 山下
滋典 野沢
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to RU2013135283/15A priority Critical patent/RU2577683C2/ru
Priority to JP2012551004A priority patent/JP5813011B2/ja
Priority to CN201180049227.XA priority patent/CN103153285B/zh
Priority to EP11854287.7A priority patent/EP2630953B1/en
Priority to BR112013016365A priority patent/BR112013016365A2/pt
Publication of WO2012091054A1 publication Critical patent/WO2012091054A1/ja
Priority to US13/837,633 priority patent/US20130202686A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons

Definitions

  • the present invention relates to a sustained-release liposome composition containing an active ingredient such as a drug.
  • a first liposome having an outer membrane formed of a plurality of lipid bilayer membranes, and a plurality of lipid bilayer membranes accommodated in an inner region of the first liposome defined by the outer membrane
  • a plurality of second liposomes having an outer membrane formed, and having a second liposome inner region defined by the outer membrane of the second liposome, and at least the second liposome inner region and the A liposome composition in which an ion gradient is formed between the first liposome and the outside.
  • the liposome composition of the present invention may contain other membrane components in addition to the main constituent components, for example, lipids other than phospholipids or derivatives thereof, membrane stabilizers, antioxidants and the like as necessary. be able to.
  • Lipids other than phospholipids are lipids that have a hydrophobic group such as a long-chain alkyl group in the molecule and do not contain a phosphate group in the molecule, and are not particularly limited, but include glyceroglycolipid, sphingoglycolipid, cholesterol And sterol derivatives such as these and derivatives such as hydrogenated products thereof.
  • a passive method which is a conventional method, was used instead of the ion gradient method.
  • the passive method is a method of preparing a liposome by dissolving a drug in the inner aqueous phase in advance.
  • a predetermined amount of donepezil hydrochloride was previously dissolved in physiological saline of the first inner aqueous phase solution, and then liposomes were prepared in the same manner as in Preparation Examples 1 to 4. Saline was also used for the outer aqueous phase.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
PCT/JP2011/080304 2010-12-27 2011-12-27 リポソーム組成物およびその製造方法 WO2012091054A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
RU2013135283/15A RU2577683C2 (ru) 2010-12-27 2011-12-27 Липосомная композиция и способ ее получения
JP2012551004A JP5813011B2 (ja) 2010-12-27 2011-12-27 リポソーム組成物およびその製造方法
CN201180049227.XA CN103153285B (zh) 2010-12-27 2011-12-27 脂质体组合物及其制造方法
EP11854287.7A EP2630953B1 (en) 2010-12-27 2011-12-27 Liposome composition and process for production thereof
BR112013016365A BR112013016365A2 (pt) 2010-12-27 2011-12-27 composição de lipossoma e processo para produção do mesmo
US13/837,633 US20130202686A1 (en) 2010-12-27 2013-03-15 Liposome composition and process for production thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010-291110 2010-12-27
JP2010291110 2010-12-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/837,633 Continuation US20130202686A1 (en) 2010-12-27 2013-03-15 Liposome composition and process for production thereof

Publications (1)

Publication Number Publication Date
WO2012091054A1 true WO2012091054A1 (ja) 2012-07-05

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ID=46383145

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PCT/JP2011/080304 WO2012091054A1 (ja) 2010-12-27 2011-12-27 リポソーム組成物およびその製造方法

Country Status (7)

Country Link
US (1) US20130202686A1 (pt)
EP (1) EP2630953B1 (pt)
JP (1) JP5813011B2 (pt)
CN (1) CN103153285B (pt)
BR (1) BR112013016365A2 (pt)
RU (1) RU2577683C2 (pt)
WO (1) WO2012091054A1 (pt)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013146386A1 (ja) * 2012-03-27 2013-10-03 学校法人関西医科大学 局所麻酔薬持続性徐放製剤
JP2013255912A (ja) * 2012-05-15 2013-12-26 Chiba Univ リポソームおよびその作製方法
WO2014046191A1 (ja) * 2012-09-21 2014-03-27 テルモ株式会社 局所麻酔薬持続徐放性リポソーム製剤
JP2014058469A (ja) * 2012-09-18 2014-04-03 Kyoto Univ 複数の被内包リポソームを内包するリポソーム及びその製造方法
JPWO2019244979A1 (ja) * 2018-06-20 2021-06-03 富士フイルム株式会社 薬物を内包するリポソーム組成物および免疫チェックポイント阻害剤を含む組合せ医薬
JPWO2020071349A1 (ja) * 2018-10-01 2021-09-02 富士フイルム株式会社 薬物を内包するリポソーム組成物およびプラチナ製剤を含む組合せ医薬
JP2022500398A (ja) * 2018-09-13 2022-01-04 タイワン リポソーム カンパニー リミテッド 鎮静薬を含む徐放性医薬組成物およびその使用
US11413244B2 (en) 2017-03-31 2022-08-16 Fujifilm Corporation Liposome composition and pharmaceutical composition

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US20200316146A1 (en) * 2016-03-25 2020-10-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Synthetically enveloped virus
CN106377468A (zh) * 2016-11-30 2017-02-08 上海儿童营养中心有限公司 防治尿布疹的组合物及含有该组合物的脂质体和护臀膏
US20210378961A1 (en) * 2018-07-24 2021-12-09 Taiwan Liposome Co., Ltd. Sustained-release pharmaceutical compositions comprising a therapeutic agent for treating dementia and uses thereof
EP3829539A4 (en) * 2018-08-02 2022-05-04 Taiwan Liposome Company, Ltd. EXTENDED RELEASE COMPOSITIONS COMPRISING A THERAPEUTIC AGENT FOR THE TREATMENT OF DEPRESSION OR ANXIETY AND USES THEREOF
WO2020033195A1 (en) * 2018-08-08 2020-02-13 Taiwan Liposome Co., Ltd. Sustained-release pharmaceutical compositions comprising an antipsychotic drug and uses thereof
WO2020102323A1 (en) * 2018-11-14 2020-05-22 Taiwan Liposome Co., Ltd. Sustained-release pharmaceutical compositions comprising a therapeutic agent for treating diseases due to reduced bone density or cartilage loss and uses thereof

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WO2008050807A1 (fr) * 2006-10-25 2008-05-02 Terumo Kabushiki Kaisha Procede de production d'une preparation de liposome
JP2009132629A (ja) * 2007-11-28 2009-06-18 Terumo Corp リポソーム製剤の製造方法
WO2010058840A1 (ja) * 2008-11-20 2010-05-27 テルモ株式会社 リポソームからの薬物放出手段および放出性評価法
JP2010260828A (ja) * 2009-05-08 2010-11-18 Kazuo Maruyama リポソーム、リポソームの製造方法、及び医薬組成物

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WO2010058840A1 (ja) * 2008-11-20 2010-05-27 テルモ株式会社 リポソームからの薬物放出手段および放出性評価法
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013146386A1 (ja) * 2012-03-27 2013-10-03 学校法人関西医科大学 局所麻酔薬持続性徐放製剤
JP2013255912A (ja) * 2012-05-15 2013-12-26 Chiba Univ リポソームおよびその作製方法
JP2014058469A (ja) * 2012-09-18 2014-04-03 Kyoto Univ 複数の被内包リポソームを内包するリポソーム及びその製造方法
WO2014046191A1 (ja) * 2012-09-21 2014-03-27 テルモ株式会社 局所麻酔薬持続徐放性リポソーム製剤
JPWO2014046191A1 (ja) * 2012-09-21 2016-08-18 テルモ株式会社 局所麻酔薬持続徐放性リポソーム製剤
US9724300B2 (en) 2012-09-21 2017-08-08 Terumo Kabushiki Kaisha Long-lasting, controlled-release local anesthetic liposome preparation
US11413244B2 (en) 2017-03-31 2022-08-16 Fujifilm Corporation Liposome composition and pharmaceutical composition
US11446247B2 (en) 2017-03-31 2022-09-20 Fujifilm Corporation Liposome composition and pharmaceutical composition
JPWO2019244979A1 (ja) * 2018-06-20 2021-06-03 富士フイルム株式会社 薬物を内包するリポソーム組成物および免疫チェックポイント阻害剤を含む組合せ医薬
JP7036919B2 (ja) 2018-06-20 2022-03-15 富士フイルム株式会社 薬物を内包するリポソーム組成物および免疫チェックポイント阻害剤を含む組合せ医薬
JP2022500398A (ja) * 2018-09-13 2022-01-04 タイワン リポソーム カンパニー リミテッド 鎮静薬を含む徐放性医薬組成物およびその使用
JP7482487B2 (ja) 2018-09-13 2024-05-14 タイワン リポソーム カンパニー リミテッド 鎮静薬を含む徐放性医薬組成物およびその使用
JP7057434B2 (ja) 2018-10-01 2022-04-19 富士フイルム株式会社 薬物を内包するリポソーム組成物およびプラチナ製剤を含む組合せ医薬
JPWO2020071349A1 (ja) * 2018-10-01 2021-09-02 富士フイルム株式会社 薬物を内包するリポソーム組成物およびプラチナ製剤を含む組合せ医薬

Also Published As

Publication number Publication date
RU2577683C2 (ru) 2016-03-20
EP2630953A4 (en) 2014-04-30
JPWO2012091054A1 (ja) 2014-06-05
JP5813011B2 (ja) 2015-11-17
EP2630953A1 (en) 2013-08-28
BR112013016365A2 (pt) 2018-06-26
RU2013135283A (ru) 2015-02-10
CN103153285B (zh) 2016-10-12
EP2630953B1 (en) 2017-08-09
CN103153285A (zh) 2013-06-12
US20130202686A1 (en) 2013-08-08

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