JP2014058469A - 複数の被内包リポソームを内包するリポソーム及びその製造方法 - Google Patents
複数の被内包リポソームを内包するリポソーム及びその製造方法 Download PDFInfo
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- JP2014058469A JP2014058469A JP2012204134A JP2012204134A JP2014058469A JP 2014058469 A JP2014058469 A JP 2014058469A JP 2012204134 A JP2012204134 A JP 2012204134A JP 2012204134 A JP2012204134 A JP 2012204134A JP 2014058469 A JP2014058469 A JP 2014058469A
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- liposome
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Abstract
【解決手段】水相に接するかたちで油相を配置した水/油界面に、第1脂質膜を形成する第1工程、被内包リポソームを形成した後、該被内包リポソームを含有した水溶液を第2脂質膜に内包させ、該被内包リポソームを複数含む液滴を作成する第2工程、前記液滴を前記油相に導入し、前記液滴を水相に移行させるとともに、内層脂質膜となる第2脂質膜の外側を第1脂質膜で覆い外層脂質膜を形成する第3工程、を備える。
【選択図】図1
Description
(2)被内包リポソームの粒径が10μm以下であることを特徴とする(1)に記載のリポソームの製造方法。
(3)複数の被内包リポソームを内包することを特徴とするリポソーム。
(4)被内包リポソームの粒径が10μm以下であることを特徴とする(3)に記載のリポソーム。
(5)(3)又は(4)のリポソームを含有することを特徴とする化粧料、医薬品又は食品。
リン脂質:レシチン
水溶性蛍光色素溶液:水性蛍光ペン(ゼブラ社製)の蛍光インクを適当な濃度で水に溶解させたもの
油相物質:ミネラルオイル
リン脂質(レシチン)を、濃度が7.5mg/mLとなるようにミネラルオイル溶媒に溶解した。マイクロチューブ容器に、リン脂質溶液を1000mg、水溶性蛍光色素溶液を50mgで混合した。この混合液を、室温で30分間超音波処理をおこなった。
サンプル瓶に、水相となる精製水を4000mg入れ、その上に濃度が7.5mg/mLのリン脂質を含むオイル相1000mgをのせた。このリン脂質は外層脂質膜となる。さらに、オイル相に作製したW/O液滴を添加した。W/O液滴が重力によりオイル相から水相まで油水界面を介して自発的に移行することで、脂質2分子膜が形成されたリポソームを作製した。
リン脂質(レシチン)を、濃度が7.5mg/mLとなるようにミネラルオイル溶媒に溶解した。続いて、マイクロチューブ容器に、リン脂質溶液を1000mg、前述で作製した被内包リポソームを含んだ水相を取り出し50mg添加した。さらに、この混合液をボルテックスミキサーで撹拌した。
サンプル瓶に、水相となる精製水を4000mg入れ、その上に濃度が7.5mg/mLのリン脂質を含むオイル相1000mgをのせた。オイル相に作製した被内包リポソームを含んだW/O液滴を添加した。W/O液滴が重力によりオイル相から水相まで油水界面を介して自発的に移行することで、被内包リポソームを内包するリポソームを作製した。
具体的には、作製した被内包リポソームを内包するリポソームと、被内包リポソーム単体との、40℃、2ヶ月保存後の経時安定性を比較した。
Claims (5)
- 複数の被内包リポソームを内包するリポソームの製造方法であって、
水相に接するかたちで油相を配置した水/油界面に、第1脂質膜を形成する第1工程、
該被内包リポソームを含有した水溶液を第2脂質膜に内包させ、該被内包リポソームを複数含む液滴を作成する第2工程、
前記液滴を前記油相に導入し、前記液滴を水相に移行させるとともに、内層脂質膜となる前記第2脂質膜の外側を前記第1脂質膜で覆い外層脂質膜を形成する第3工程、
を備えることを特徴とするリポソームの製造方法。 - 前記被内包リポソームの粒径が10μm以下であることを特徴とする請求項1に記載のリポソームの製造方法。
- 複数の被内包リポソームを内包することを特徴とするリポソーム。
- 前記被内包リポソームの粒径が10μm以下であることを特徴とする請求項3に記載のリポソーム。
- 請求項3又は4のリポソームを含有することを特徴とする化粧料、医薬品又は食品。
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WO2018160026A1 (ko) * | 2017-03-02 | 2018-09-07 | 단디바이오사이언스 주식회사 | 면역활성물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
WO2018160027A1 (ko) * | 2017-03-02 | 2018-09-07 | 단디바이오사이언스 주식회사 | 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
US10980898B2 (en) | 2017-07-07 | 2021-04-20 | Drexel University | Imaging agents |
CN111032036A (zh) * | 2017-07-07 | 2020-04-17 | 德雷克塞尔大学 | 电压活化的治疗、诊断和/或诊疗构建体 |
JP2020526509A (ja) * | 2017-07-07 | 2020-08-31 | ドレクセル ユニバーシティ | 電位活性化型の治療用構築物、診断用構築物、および/またはセラノスティック用構築物 |
WO2019010418A1 (en) * | 2017-07-07 | 2019-01-10 | Drexel University | THERAPEUTIC, DIAGNOSTIC AND / OR THERANOSTIC CONSTRUCTS ACTIVATED BY VOLTAGE |
US11266752B2 (en) | 2017-07-07 | 2022-03-08 | Drexel University | Methods of imaging and delivering therapeutic agents |
US11266751B2 (en) | 2017-07-07 | 2022-03-08 | Drexel University | Methods of imaging and delivering therapeutic agents |
CN111032036B (zh) * | 2017-07-07 | 2023-06-16 | 德雷克塞尔大学 | 电压活化的治疗、诊断和/或诊疗构建体 |
JP7330163B2 (ja) | 2017-07-07 | 2023-08-21 | ドレクセル ユニバーシティ | 電位活性化型の治療用構築物、診断用構築物、および/またはセラノスティック用構築物 |
IL271664B1 (en) * | 2017-07-07 | 2023-12-01 | Univ Drexel | Medical, Diagnostic and Medical-Diagnostic Patterns Powered-Voltage |
IL271664B2 (en) * | 2017-07-07 | 2024-04-01 | Univ Drexel | Medical, Diagnostic, and Medical-Diagnostic Patterns Powered-Voltage |
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