WO2010076338A1 - Verfahren zur herstellung einer antiinfektiösen beschichtung auf implantaten - Google Patents

Verfahren zur herstellung einer antiinfektiösen beschichtung auf implantaten Download PDF

Info

Publication number
WO2010076338A1
WO2010076338A1 PCT/EP2010/050010 EP2010050010W WO2010076338A1 WO 2010076338 A1 WO2010076338 A1 WO 2010076338A1 EP 2010050010 W EP2010050010 W EP 2010050010W WO 2010076338 A1 WO2010076338 A1 WO 2010076338A1
Authority
WO
WIPO (PCT)
Prior art keywords
oxide layer
titanium
metal
implants
infective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/050010
Other languages
German (de)
English (en)
French (fr)
Inventor
Hans-Georg Neumann
Cornelia Prinz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DOT GmbH
Original Assignee
DOT GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DOT GmbH filed Critical DOT GmbH
Priority to US13/130,431 priority Critical patent/US8828552B2/en
Priority to CN201080003993.8A priority patent/CN102271721B/zh
Priority to CA2748760A priority patent/CA2748760C/en
Priority to JP2011544053A priority patent/JP5647145B2/ja
Priority to AU2010203260A priority patent/AU2010203260B9/en
Publication of WO2010076338A1 publication Critical patent/WO2010076338A1/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Definitions

  • the invention relates to a method for producing an anti-infective coating on implants containing titanium or made of titanium.
  • Titanium alloys using a sol-gel process to provide a titanium oxide coating in the homogeneous metal ions such as silver or copper are distributed.
  • a heat treatment By heating to about 500 ° C, a ceramization of the coating takes place.
  • the heat treatment has the disadvantage for the implants that it leads to loss of strength. It is therefore not suitable for implants that must have a high fatigue strength.
  • the invention has for its object to provide a coating method with which it is possible for implants made of titanium or titanium containing the achieved with the anodic oxidation type II optimization of the mechanical properties to unite with the anti-infective properties.
  • This object is achieved in that the implants are oxidized anodically in an alkaline solution, then deposited on this surface metal, which has anti-infective properties, electrodeposited and then the metal-containing oxide layer is solidified.
  • a conversion layer containing oxygen and possibly other atoms, and a porous titanium oxide layer having sufficient conductivity can be formed, which is electrically conductive in the pores, so that it can be electrodeposited in its metal.
  • the metal-containing oxide layer is solidified and weakly bound oxide and metal particles removed or more intensively connected with each other and with the implant surface.
  • a porous oxide layer is formed in the second step of the galvanic entry of the metal in the porous layer takes place and in a third step, the metal-enriched oxide layer is solidified by radiation and can be more or less removed by removing weaker bound oxide or metal particles or more intensively connected to each other and the implant.
  • the onset of physiological conditions elution of the metal can be adjusted by the variation of the average metal occupancy of the implant surface in their concentration so that An antimicrobial or anti-bacterial effect without substantial damage to the cells of the surrounding body tissue is achieved.
  • Particularly suitable metals are copper, silver and zinc.
  • the catalytic effect on angiogenesis is expected to improve blood flow to the newly formed body tissue.
  • the thickness of the metal-containing layer is advantageously 8-15 ⁇ m, preferably 10 ⁇ m.
  • the solidification of the metal-containing oxide layer is advantageously carried out by blasting with glass beads.
  • TiAl6V4 specimens are based on the principle of anodic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
PCT/EP2010/050010 2009-01-05 2010-01-04 Verfahren zur herstellung einer antiinfektiösen beschichtung auf implantaten Ceased WO2010076338A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US13/130,431 US8828552B2 (en) 2009-01-05 2010-01-04 Method for producing an anti-infective coating on implants
CN201080003993.8A CN102271721B (zh) 2009-01-05 2010-01-04 用于在植入物上制造抗感染覆层的方法
CA2748760A CA2748760C (en) 2009-01-05 2010-01-04 Method for producing an anti-infective coating on implants
JP2011544053A JP5647145B2 (ja) 2009-01-05 2010-01-04 インプラント上の抗感染性コーティングの製造方法
AU2010203260A AU2010203260B9 (en) 2009-01-05 2010-01-04 Method for producing an anti-infective coating on implants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09100006.7 2009-01-05
EP09100006A EP2204199B1 (de) 2009-01-05 2009-01-05 Verfahren zur Herstellung einer antiinfektiösen Beschichtung auf Implantaten

Publications (1)

Publication Number Publication Date
WO2010076338A1 true WO2010076338A1 (de) 2010-07-08

Family

ID=40677900

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/050010 Ceased WO2010076338A1 (de) 2009-01-05 2010-01-04 Verfahren zur herstellung einer antiinfektiösen beschichtung auf implantaten

Country Status (9)

Country Link
US (1) US8828552B2 (enExample)
EP (1) EP2204199B1 (enExample)
JP (1) JP5647145B2 (enExample)
CN (1) CN102271721B (enExample)
AT (1) ATE530205T1 (enExample)
AU (1) AU2010203260B9 (enExample)
CA (1) CA2748760C (enExample)
ES (1) ES2376539T3 (enExample)
WO (1) WO2010076338A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI400100B (zh) * 2010-09-29 2013-07-01 Metal Ind Res & Dev Ct Medical equipment and manufacturing methods thereof
DE102012210804A1 (de) * 2012-06-26 2014-01-02 Innovent E.V. Verfahren zur Erzeugung einer bakteriziden Schicht auf einem Grundkörper aus Titan oder einer Titanbasislegierung

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009023459B4 (de) * 2009-06-02 2017-08-31 Aap Implantate Ag Osteosynthese mit Nanosilber
DE102009046743A1 (de) * 2009-11-17 2011-05-19 Primus Oberflächentechnik GmbH & Co. KG Verfahren zur Herstellung einer antimikrobiellen Oberfläche eines Gegenstandes und Gegenstand mit einer antimikrobiellen Oberfläche
EP2693978B1 (en) * 2011-04-01 2018-11-07 Washington State University Research Foundation Materials with modified surfaces and methods of manufacturing
KR101278740B1 (ko) 2012-02-17 2013-06-25 영남대학교 산학협력단 물유리 코팅층을 포함하는 임플란트 및 이의 제조 방법
CA2949664A1 (en) 2014-05-18 2015-11-26 Carlos M. Lacerda Antibacterial composition, antibacterial cases and accessories for handheld electronics, and method of making antibacterial cases for handheld electronics
US11413376B2 (en) 2015-03-30 2022-08-16 C. R. Bard, Inc. Application of antimicrobial agents to medical devices
US10064273B2 (en) 2015-10-20 2018-08-28 MR Label Company Antimicrobial copper sheet overlays and related methods for making and using
EP3407926A2 (en) * 2016-01-25 2018-12-05 Smith & Nephew, Inc. Orthopaedic implant
PL232314B1 (pl) * 2016-05-06 2019-06-28 Gen Electric Maszyna przepływowa zawierająca system regulacji luzu
CN106420119B (zh) * 2016-11-29 2017-10-31 淮阴工学院 一种高抗菌性钛合金人工髋关节的成形方法
WO2018187782A1 (en) * 2017-04-07 2018-10-11 The Board Of Trustees Of The University Of Illinois Nanostructured polymer-based compositions and methods to fabricate the same
CN107893252A (zh) * 2017-11-22 2018-04-10 四川大学 钛基材料表面具有软组织密封性的生物活性涂层的原位制备方法及其应用
WO2019199292A1 (en) 2018-04-11 2019-10-17 Hewlett-Packard Development Company, L.P. Device housings with glass beads
DE102019108327A1 (de) * 2019-03-29 2020-10-01 Karl Leibinger Medizintechnik Gmbh & Co. Kg Implantat mit intrinsischer antimikrobieller Wirksamkeit und Verfahren zu dessen Herstellung
CN118600504B (zh) * 2024-06-21 2024-12-17 东莞市禹坤纳米注塑技术有限公司 一种钛合金表面处理工艺

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5833463A (en) * 1996-12-09 1998-11-10 Hurson; Steven M. Titanium surface treated dental screw for attaching a prosthetic component to an implant
DE20020649U1 (de) 2000-12-06 2002-04-11 stryker Trauma GmbH, 24232 Schönkirchen Vorrichtung für den chirurgischen oder therapeutischen Gebrauch, insbesondere Implantate und chirurgische Instrumente sowie deren Zubehör
DE10241137A1 (de) * 2002-09-03 2004-03-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Metallisierung von Kunststoffen
US20050060021A1 (en) * 2003-09-16 2005-03-17 O'brien Barry Medical devices
DE10243132B4 (de) 2002-09-17 2006-09-14 Biocer Entwicklungs Gmbh Antiinfektiöse, biokompatible Titanoxid-Beschichtungen für Implantate sowie Verfahren zu deren Herstellung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2009A (en) * 1841-03-18 Improvement in machines for boring war-rockets
JP2740071B2 (ja) * 1992-03-31 1998-04-15 日新製鋼株式会社 インプラント用金属焼結体の製造方法
JPH08289927A (ja) 1995-04-21 1996-11-05 Nikon Corp 骨内インプラント及びその製造方法
JP2005287985A (ja) 2004-04-05 2005-10-20 Gha:Kk 炎症／臭い抑制部材及びその製造方法並びにこれを用いた義体及びギブス
US20060229715A1 (en) * 2005-03-29 2006-10-12 Sdgi Holdings, Inc. Implants incorporating nanotubes and methods for producing the same
US8414908B2 (en) * 2005-04-28 2013-04-09 The Regents Of The University Of California Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same
CN100430099C (zh) * 2005-12-23 2008-11-05 中国科学院金属研究所 一种钛或钛合金表面生物活性涂层及其制备方法
CA2654235C (en) 2006-06-12 2015-01-06 Accentus Plc Metal implant comprising an anodised oxide surface coated with a ceramic, and with biocidal metal ions
JP2010516403A (ja) 2007-01-26 2010-05-20 ボストン サイエンティフィック リミテッド 植込み型医療用内部人工器官
US9095391B2 (en) * 2007-06-11 2015-08-04 Aeolin Llc Osseointegration and biointegration coatings for bone screw implants

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5833463A (en) * 1996-12-09 1998-11-10 Hurson; Steven M. Titanium surface treated dental screw for attaching a prosthetic component to an implant
DE20020649U1 (de) 2000-12-06 2002-04-11 stryker Trauma GmbH, 24232 Schönkirchen Vorrichtung für den chirurgischen oder therapeutischen Gebrauch, insbesondere Implantate und chirurgische Instrumente sowie deren Zubehör
DE10241137A1 (de) * 2002-09-03 2004-03-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Metallisierung von Kunststoffen
DE10243132B4 (de) 2002-09-17 2006-09-14 Biocer Entwicklungs Gmbh Antiinfektiöse, biokompatible Titanoxid-Beschichtungen für Implantate sowie Verfahren zu deren Herstellung
US20050060021A1 (en) * 2003-09-16 2005-03-17 O'brien Barry Medical devices

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI400100B (zh) * 2010-09-29 2013-07-01 Metal Ind Res & Dev Ct Medical equipment and manufacturing methods thereof
DE102012210804A1 (de) * 2012-06-26 2014-01-02 Innovent E.V. Verfahren zur Erzeugung einer bakteriziden Schicht auf einem Grundkörper aus Titan oder einer Titanbasislegierung
DE102012210804B4 (de) * 2012-06-26 2014-07-10 Innovent E.V. Verfahren zur Erzeugung einer bakteriziden Schicht auf einem Grundkörper aus Titan oder einer Titanbasislegierung

Also Published As

Publication number Publication date
AU2010203260B9 (en) 2013-10-31
CA2748760C (en) 2015-07-21
AU2010203260B2 (en) 2013-10-17
US8828552B2 (en) 2014-09-09
ES2376539T3 (es) 2012-03-14
AU2010203260A1 (en) 2011-07-14
US20120024712A1 (en) 2012-02-02
JP2012514483A (ja) 2012-06-28
EP2204199A1 (de) 2010-07-07
JP5647145B2 (ja) 2014-12-24
CA2748760A1 (en) 2010-07-08
EP2204199B1 (de) 2011-10-26
CN102271721B (zh) 2014-12-10
ATE530205T1 (de) 2011-11-15
CN102271721A (zh) 2011-12-07

Similar Documents

Publication Publication Date Title
EP2204199B1 (de) Verfahren zur Herstellung einer antiinfektiösen Beschichtung auf Implantaten
DE102009023459B4 (de) Osteosynthese mit Nanosilber
DE102010054046B4 (de) Antibakterielle Beschichtung für ein Implantat und Implantat.
DE102011007424B4 (de) Verfahren zur Herstellung einer Beschichtung auf der Oberfläche eines Substrats auf Basis von Leichtmetallen durch plasmaelektrolytische Oxidation und beschichtetes Substrat
EP1941918A2 (de) Verfahren zur Herstellung einer korrosionshemmenden Beschichtung auf einem Implantat aus einer biokorrodierbaren Magnesiumlegierung sowie nach dem Verfahren hergestelltes Implantat
DE102018129604C5 (de) Biodegradierbares Implantat, das ein beschichtetes Magnesiumlegierungsprodukt umfasst
EP1886702A2 (de) Implantat aus einem biokorrodierbaren metallischen Werkstoff mit einer Beschichtung aus einer Organosiliziumverbindung
DE112017004063B4 (de) Verfahren zur Herstellung einer Dickbeschichtung mit schichtweisem Aufbau
DE102015115958A1 (de) Medizinisches Glaselement
WO2007087795A2 (de) Oligodynamisch wirksame vorrichtung und verfahren zu ihrer herstellung
EP2786771B1 (de) Verfahren zur Herstellung eines funktionalisierten Implantats sowie funktionalisiertes Implantat
DE102009041248A1 (de) Bioaktiv beschichtete Metallimplantate und Verfahren zu deren Herstellung
DE102012210807A1 (de) Verfahren zur Erzeugung einer bakteriziden Schicht
EP2617439B1 (de) Antibakterielle und osteoinduktive implantatbeschichtung, verfahren zur herstellung einer solchen beschichtung sowie damit beschichtetes implantat
EP2236163A2 (de) Implantat aus einem biokorrodierbaren metallischen Werkstoff mit einer nanopartikel-haltigen Silanbeschichtung und dazugehöriges Herstellungsverfahren
DE102013217085A1 (de) Verfahren zur Verbesserung der Biokompatibilität einer Oberfläche
DE19643555A1 (de) Metallischer Gegenstand mit einer dünnen mehrphasigen Oxidschicht sowie Verfahren zu dessen Herstellung
DE102017125635A1 (de) Implantat aus einem Metall
DE102009006783A1 (de) Hydrophile Schicht und Beschichtungszusammensetzung zur Herstellung der Schicht sowie Verfahren zur Herstellung der Beschichtungszusammensetzung
Arias Electrophoretic deposition of organic/inorganic composite coatings on metallic substrates for bone replacement applications: mechanisms and development of new bioactive materials based on polysaccharides
DE10129900C1 (de) Verfahren zur Wärmebehandlung eines Kaltbandes mit einer Oberflächenbeschichtung aus Ni und/oder Co, durch das Verfahren herstellbares Blech und durch das Verfahren herstellbarer Batteriebecher
DE102012109272B4 (de) Nanostrukturierte offenporige Diffusionsschicht für die kontrollierte Abgabe von Kupferionen zum gezielten Abtöten von MRE-Keimen
DE102015211685A1 (de) Elektrolyt zur Abscheidung von Zinn-Nickel-Schichten
DE102019219355A1 (de) Implantat, Implantatkomponente und Verfahren zu deren Herstellung
Hoyer et al. Einfluss der Oberflächenbehandlung auf das Korrosionsverhalten von Magnesiumlegierungen.

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201080003993.8

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10701484

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2596/KOLNP/2011

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2010203260

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2748760

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2011544053

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2010203260

Country of ref document: AU

Date of ref document: 20100104

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 13130431

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 10701484

Country of ref document: EP

Kind code of ref document: A1