ES2376539T3 - Procedimiento para la fabricación de un recubrimiento antiinfeccioso sobre implantes. - Google Patents
Procedimiento para la fabricación de un recubrimiento antiinfeccioso sobre implantes. Download PDFInfo
- Publication number
- ES2376539T3 ES2376539T3 ES09100006T ES09100006T ES2376539T3 ES 2376539 T3 ES2376539 T3 ES 2376539T3 ES 09100006 T ES09100006 T ES 09100006T ES 09100006 T ES09100006 T ES 09100006T ES 2376539 T3 ES2376539 T3 ES 2376539T3
- Authority
- ES
- Spain
- Prior art keywords
- oxide layer
- metal
- copper
- implants
- titanium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007943 implant Substances 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims abstract description 13
- 238000000576 coating method Methods 0.000 title claims description 13
- 239000011248 coating agent Substances 0.000 title claims description 12
- 230000002924 anti-infective effect Effects 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 229910052751 metal Inorganic materials 0.000 claims abstract description 16
- 239000002184 metal Substances 0.000 claims abstract description 16
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229910052802 copper Inorganic materials 0.000 claims abstract description 14
- 239000010949 copper Substances 0.000 claims abstract description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 9
- 230000003647 oxidation Effects 0.000 claims abstract description 8
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 8
- 229910052709 silver Inorganic materials 0.000 claims abstract description 6
- 239000004332 silver Substances 0.000 claims abstract description 6
- 239000003792 electrolyte Substances 0.000 claims abstract description 5
- 239000011521 glass Substances 0.000 claims abstract description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000012670 alkaline solution Substances 0.000 claims abstract description 3
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 3
- 239000011701 zinc Substances 0.000 claims abstract description 3
- 239000004115 Sodium Silicate Substances 0.000 claims abstract 2
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910052911 sodium silicate Inorganic materials 0.000 claims abstract 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 10
- 239000010936 titanium Substances 0.000 claims description 10
- 229910052719 titanium Inorganic materials 0.000 claims description 10
- 238000005422 blasting Methods 0.000 claims description 5
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000007711 solidification Methods 0.000 claims description 3
- 239000011148 porous material Substances 0.000 claims description 2
- 208000001840 Dandruff Diseases 0.000 claims 1
- 239000013641 positive control Substances 0.000 claims 1
- 235000011121 sodium hydroxide Nutrition 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 abstract description 2
- 239000011324 bead Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 229910001069 Ti alloy Inorganic materials 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09100006A EP2204199B1 (de) | 2009-01-05 | 2009-01-05 | Verfahren zur Herstellung einer antiinfektiösen Beschichtung auf Implantaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2376539T3 true ES2376539T3 (es) | 2012-03-14 |
Family
ID=40677900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09100006T Active ES2376539T3 (es) | 2009-01-05 | 2009-01-05 | Procedimiento para la fabricación de un recubrimiento antiinfeccioso sobre implantes. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8828552B2 (enExample) |
| EP (1) | EP2204199B1 (enExample) |
| JP (1) | JP5647145B2 (enExample) |
| CN (1) | CN102271721B (enExample) |
| AT (1) | ATE530205T1 (enExample) |
| AU (1) | AU2010203260B9 (enExample) |
| CA (1) | CA2748760C (enExample) |
| ES (1) | ES2376539T3 (enExample) |
| WO (1) | WO2010076338A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009023459B4 (de) * | 2009-06-02 | 2017-08-31 | Aap Implantate Ag | Osteosynthese mit Nanosilber |
| DE102009046743A1 (de) * | 2009-11-17 | 2011-05-19 | Primus Oberflächentechnik GmbH & Co. KG | Verfahren zur Herstellung einer antimikrobiellen Oberfläche eines Gegenstandes und Gegenstand mit einer antimikrobiellen Oberfläche |
| TWI400100B (zh) * | 2010-09-29 | 2013-07-01 | Metal Ind Res & Dev Ct | Medical equipment and manufacturing methods thereof |
| EP2693978B1 (en) * | 2011-04-01 | 2018-11-07 | Washington State University Research Foundation | Materials with modified surfaces and methods of manufacturing |
| KR101278740B1 (ko) | 2012-02-17 | 2013-06-25 | 영남대학교 산학협력단 | 물유리 코팅층을 포함하는 임플란트 및 이의 제조 방법 |
| DE102012210804B4 (de) * | 2012-06-26 | 2014-07-10 | Innovent E.V. | Verfahren zur Erzeugung einer bakteriziden Schicht auf einem Grundkörper aus Titan oder einer Titanbasislegierung |
| CA2949664A1 (en) | 2014-05-18 | 2015-11-26 | Carlos M. Lacerda | Antibacterial composition, antibacterial cases and accessories for handheld electronics, and method of making antibacterial cases for handheld electronics |
| US11413376B2 (en) | 2015-03-30 | 2022-08-16 | C. R. Bard, Inc. | Application of antimicrobial agents to medical devices |
| US10064273B2 (en) | 2015-10-20 | 2018-08-28 | MR Label Company | Antimicrobial copper sheet overlays and related methods for making and using |
| EP3407926A2 (en) * | 2016-01-25 | 2018-12-05 | Smith & Nephew, Inc. | Orthopaedic implant |
| PL232314B1 (pl) * | 2016-05-06 | 2019-06-28 | Gen Electric | Maszyna przepływowa zawierająca system regulacji luzu |
| CN106420119B (zh) * | 2016-11-29 | 2017-10-31 | 淮阴工学院 | 一种高抗菌性钛合金人工髋关节的成形方法 |
| WO2018187782A1 (en) * | 2017-04-07 | 2018-10-11 | The Board Of Trustees Of The University Of Illinois | Nanostructured polymer-based compositions and methods to fabricate the same |
| CN107893252A (zh) * | 2017-11-22 | 2018-04-10 | 四川大学 | 钛基材料表面具有软组织密封性的生物活性涂层的原位制备方法及其应用 |
| WO2019199292A1 (en) | 2018-04-11 | 2019-10-17 | Hewlett-Packard Development Company, L.P. | Device housings with glass beads |
| DE102019108327A1 (de) * | 2019-03-29 | 2020-10-01 | Karl Leibinger Medizintechnik Gmbh & Co. Kg | Implantat mit intrinsischer antimikrobieller Wirksamkeit und Verfahren zu dessen Herstellung |
| CN118600504B (zh) * | 2024-06-21 | 2024-12-17 | 东莞市禹坤纳米注塑技术有限公司 | 一种钛合金表面处理工艺 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2009A (en) * | 1841-03-18 | Improvement in machines for boring war-rockets | ||
| JP2740071B2 (ja) * | 1992-03-31 | 1998-04-15 | 日新製鋼株式会社 | インプラント用金属焼結体の製造方法 |
| JPH08289927A (ja) | 1995-04-21 | 1996-11-05 | Nikon Corp | 骨内インプラント及びその製造方法 |
| US5833463A (en) * | 1996-12-09 | 1998-11-10 | Hurson; Steven M. | Titanium surface treated dental screw for attaching a prosthetic component to an implant |
| DE20020649U1 (de) * | 2000-12-06 | 2002-04-11 | stryker Trauma GmbH, 24232 Schönkirchen | Vorrichtung für den chirurgischen oder therapeutischen Gebrauch, insbesondere Implantate und chirurgische Instrumente sowie deren Zubehör |
| DE10241137B4 (de) * | 2002-09-03 | 2008-05-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Metallisierung von Kunststoffen |
| DE10243132B4 (de) * | 2002-09-17 | 2006-09-14 | Biocer Entwicklungs Gmbh | Antiinfektiöse, biokompatible Titanoxid-Beschichtungen für Implantate sowie Verfahren zu deren Herstellung |
| US7488343B2 (en) * | 2003-09-16 | 2009-02-10 | Boston Scientific Scimed, Inc. | Medical devices |
| JP2005287985A (ja) | 2004-04-05 | 2005-10-20 | Gha:Kk | 炎症／臭い抑制部材及びその製造方法並びにこれを用いた義体及びギブス |
| US20060229715A1 (en) * | 2005-03-29 | 2006-10-12 | Sdgi Holdings, Inc. | Implants incorporating nanotubes and methods for producing the same |
| US8414908B2 (en) * | 2005-04-28 | 2013-04-09 | The Regents Of The University Of California | Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same |
| CN100430099C (zh) * | 2005-12-23 | 2008-11-05 | 中国科学院金属研究所 | 一种钛或钛合金表面生物活性涂层及其制备方法 |
| CA2654235C (en) | 2006-06-12 | 2015-01-06 | Accentus Plc | Metal implant comprising an anodised oxide surface coated with a ceramic, and with biocidal metal ions |
| JP2010516403A (ja) | 2007-01-26 | 2010-05-20 | ボストン サイエンティフィック リミテッド | 植込み型医療用内部人工器官 |
| US9095391B2 (en) * | 2007-06-11 | 2015-08-04 | Aeolin Llc | Osseointegration and biointegration coatings for bone screw implants |
-
2009
- 2009-01-05 EP EP09100006A patent/EP2204199B1/de active Active
- 2009-01-05 AT AT09100006T patent/ATE530205T1/de active
- 2009-01-05 ES ES09100006T patent/ES2376539T3/es active Active
-
2010
- 2010-01-04 WO PCT/EP2010/050010 patent/WO2010076338A1/de not_active Ceased
- 2010-01-04 AU AU2010203260A patent/AU2010203260B9/en not_active Ceased
- 2010-01-04 US US13/130,431 patent/US8828552B2/en active Active
- 2010-01-04 CN CN201080003993.8A patent/CN102271721B/zh active Active
- 2010-01-04 JP JP2011544053A patent/JP5647145B2/ja not_active Expired - Fee Related
- 2010-01-04 CA CA2748760A patent/CA2748760C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010203260B9 (en) | 2013-10-31 |
| CA2748760C (en) | 2015-07-21 |
| AU2010203260B2 (en) | 2013-10-17 |
| US8828552B2 (en) | 2014-09-09 |
| AU2010203260A1 (en) | 2011-07-14 |
| US20120024712A1 (en) | 2012-02-02 |
| JP2012514483A (ja) | 2012-06-28 |
| EP2204199A1 (de) | 2010-07-07 |
| JP5647145B2 (ja) | 2014-12-24 |
| CA2748760A1 (en) | 2010-07-08 |
| EP2204199B1 (de) | 2011-10-26 |
| CN102271721B (zh) | 2014-12-10 |
| ATE530205T1 (de) | 2011-11-15 |
| WO2010076338A1 (de) | 2010-07-08 |
| CN102271721A (zh) | 2011-12-07 |
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