CN102271721B - 用于在植入物上制造抗感染覆层的方法 - Google Patents
用于在植入物上制造抗感染覆层的方法 Download PDFInfo
- Publication number
- CN102271721B CN102271721B CN201080003993.8A CN201080003993A CN102271721B CN 102271721 B CN102271721 B CN 102271721B CN 201080003993 A CN201080003993 A CN 201080003993A CN 102271721 B CN102271721 B CN 102271721B
- Authority
- CN
- China
- Prior art keywords
- metal
- oxide layer
- titanium oxide
- implant
- titanium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007943 implant Substances 0.000 title claims abstract description 23
- 238000000576 coating method Methods 0.000 title claims abstract description 20
- 239000011248 coating agent Substances 0.000 title claims abstract description 16
- 230000002924 anti-infective effect Effects 0.000 title claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 5
- 229910052751 metal Inorganic materials 0.000 claims abstract description 20
- 239000002184 metal Substances 0.000 claims abstract description 20
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000010936 titanium Substances 0.000 claims abstract description 14
- 229910052719 titanium Inorganic materials 0.000 claims abstract description 14
- 230000003647 oxidation Effects 0.000 claims abstract description 7
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 7
- 239000012670 alkaline solution Substances 0.000 claims abstract description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000010949 copper Substances 0.000 claims description 12
- 229910052802 copper Inorganic materials 0.000 claims description 12
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 238000004070 electrodeposition Methods 0.000 claims description 5
- 239000003792 electrolyte Substances 0.000 claims description 5
- 229910052709 silver Inorganic materials 0.000 claims description 5
- 239000004332 silver Substances 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 4
- 238000005480 shot peening Methods 0.000 claims description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 239000004115 Sodium Silicate Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims 1
- 229910052911 sodium silicate Inorganic materials 0.000 claims 1
- 238000005457 optimization Methods 0.000 abstract description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 229910044991 metal oxide Inorganic materials 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000013528 metallic particle Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000000250 revascularization Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09100006.7 | 2009-01-05 | ||
| EP09100006A EP2204199B1 (de) | 2009-01-05 | 2009-01-05 | Verfahren zur Herstellung einer antiinfektiösen Beschichtung auf Implantaten |
| PCT/EP2010/050010 WO2010076338A1 (de) | 2009-01-05 | 2010-01-04 | Verfahren zur herstellung einer antiinfektiösen beschichtung auf implantaten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102271721A CN102271721A (zh) | 2011-12-07 |
| CN102271721B true CN102271721B (zh) | 2014-12-10 |
Family
ID=40677900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080003993.8A Active CN102271721B (zh) | 2009-01-05 | 2010-01-04 | 用于在植入物上制造抗感染覆层的方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8828552B2 (enExample) |
| EP (1) | EP2204199B1 (enExample) |
| JP (1) | JP5647145B2 (enExample) |
| CN (1) | CN102271721B (enExample) |
| AT (1) | ATE530205T1 (enExample) |
| AU (1) | AU2010203260B9 (enExample) |
| CA (1) | CA2748760C (enExample) |
| ES (1) | ES2376539T3 (enExample) |
| WO (1) | WO2010076338A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009023459B4 (de) * | 2009-06-02 | 2017-08-31 | Aap Implantate Ag | Osteosynthese mit Nanosilber |
| DE102009046743A1 (de) * | 2009-11-17 | 2011-05-19 | Primus Oberflächentechnik GmbH & Co. KG | Verfahren zur Herstellung einer antimikrobiellen Oberfläche eines Gegenstandes und Gegenstand mit einer antimikrobiellen Oberfläche |
| TWI400100B (zh) * | 2010-09-29 | 2013-07-01 | Metal Ind Res & Dev Ct | Medical equipment and manufacturing methods thereof |
| EP2693978B1 (en) * | 2011-04-01 | 2018-11-07 | Washington State University Research Foundation | Materials with modified surfaces and methods of manufacturing |
| KR101278740B1 (ko) | 2012-02-17 | 2013-06-25 | 영남대학교 산학협력단 | 물유리 코팅층을 포함하는 임플란트 및 이의 제조 방법 |
| DE102012210804B4 (de) * | 2012-06-26 | 2014-07-10 | Innovent E.V. | Verfahren zur Erzeugung einer bakteriziden Schicht auf einem Grundkörper aus Titan oder einer Titanbasislegierung |
| CA2949664A1 (en) | 2014-05-18 | 2015-11-26 | Carlos M. Lacerda | Antibacterial composition, antibacterial cases and accessories for handheld electronics, and method of making antibacterial cases for handheld electronics |
| US11413376B2 (en) | 2015-03-30 | 2022-08-16 | C. R. Bard, Inc. | Application of antimicrobial agents to medical devices |
| US10064273B2 (en) | 2015-10-20 | 2018-08-28 | MR Label Company | Antimicrobial copper sheet overlays and related methods for making and using |
| EP3407926A2 (en) * | 2016-01-25 | 2018-12-05 | Smith & Nephew, Inc. | Orthopaedic implant |
| PL232314B1 (pl) * | 2016-05-06 | 2019-06-28 | Gen Electric | Maszyna przepływowa zawierająca system regulacji luzu |
| CN106420119B (zh) * | 2016-11-29 | 2017-10-31 | 淮阴工学院 | 一种高抗菌性钛合金人工髋关节的成形方法 |
| WO2018187782A1 (en) * | 2017-04-07 | 2018-10-11 | The Board Of Trustees Of The University Of Illinois | Nanostructured polymer-based compositions and methods to fabricate the same |
| CN107893252A (zh) * | 2017-11-22 | 2018-04-10 | 四川大学 | 钛基材料表面具有软组织密封性的生物活性涂层的原位制备方法及其应用 |
| WO2019199292A1 (en) | 2018-04-11 | 2019-10-17 | Hewlett-Packard Development Company, L.P. | Device housings with glass beads |
| DE102019108327A1 (de) * | 2019-03-29 | 2020-10-01 | Karl Leibinger Medizintechnik Gmbh & Co. Kg | Implantat mit intrinsischer antimikrobieller Wirksamkeit und Verfahren zu dessen Herstellung |
| CN118600504B (zh) * | 2024-06-21 | 2024-12-17 | 东莞市禹坤纳米注塑技术有限公司 | 一种钛合金表面处理工艺 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10241137A1 (de) * | 2002-09-03 | 2004-03-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Metallisierung von Kunststoffen |
| CN1986003A (zh) * | 2005-12-23 | 2007-06-27 | 中国科学院金属研究所 | 一种钛或钛合金表面生物活性涂层及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2009A (en) * | 1841-03-18 | Improvement in machines for boring war-rockets | ||
| JP2740071B2 (ja) * | 1992-03-31 | 1998-04-15 | 日新製鋼株式会社 | インプラント用金属焼結体の製造方法 |
| JPH08289927A (ja) | 1995-04-21 | 1996-11-05 | Nikon Corp | 骨内インプラント及びその製造方法 |
| US5833463A (en) * | 1996-12-09 | 1998-11-10 | Hurson; Steven M. | Titanium surface treated dental screw for attaching a prosthetic component to an implant |
| DE20020649U1 (de) * | 2000-12-06 | 2002-04-11 | stryker Trauma GmbH, 24232 Schönkirchen | Vorrichtung für den chirurgischen oder therapeutischen Gebrauch, insbesondere Implantate und chirurgische Instrumente sowie deren Zubehör |
| DE10243132B4 (de) * | 2002-09-17 | 2006-09-14 | Biocer Entwicklungs Gmbh | Antiinfektiöse, biokompatible Titanoxid-Beschichtungen für Implantate sowie Verfahren zu deren Herstellung |
| US7488343B2 (en) * | 2003-09-16 | 2009-02-10 | Boston Scientific Scimed, Inc. | Medical devices |
| JP2005287985A (ja) | 2004-04-05 | 2005-10-20 | Gha:Kk | 炎症／臭い抑制部材及びその製造方法並びにこれを用いた義体及びギブス |
| US20060229715A1 (en) * | 2005-03-29 | 2006-10-12 | Sdgi Holdings, Inc. | Implants incorporating nanotubes and methods for producing the same |
| US8414908B2 (en) * | 2005-04-28 | 2013-04-09 | The Regents Of The University Of California | Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same |
| CA2654235C (en) | 2006-06-12 | 2015-01-06 | Accentus Plc | Metal implant comprising an anodised oxide surface coated with a ceramic, and with biocidal metal ions |
| JP2010516403A (ja) | 2007-01-26 | 2010-05-20 | ボストン サイエンティフィック リミテッド | 植込み型医療用内部人工器官 |
| US9095391B2 (en) * | 2007-06-11 | 2015-08-04 | Aeolin Llc | Osseointegration and biointegration coatings for bone screw implants |
-
2009
- 2009-01-05 EP EP09100006A patent/EP2204199B1/de active Active
- 2009-01-05 AT AT09100006T patent/ATE530205T1/de active
- 2009-01-05 ES ES09100006T patent/ES2376539T3/es active Active
-
2010
- 2010-01-04 WO PCT/EP2010/050010 patent/WO2010076338A1/de not_active Ceased
- 2010-01-04 AU AU2010203260A patent/AU2010203260B9/en not_active Ceased
- 2010-01-04 US US13/130,431 patent/US8828552B2/en active Active
- 2010-01-04 CN CN201080003993.8A patent/CN102271721B/zh active Active
- 2010-01-04 JP JP2011544053A patent/JP5647145B2/ja not_active Expired - Fee Related
- 2010-01-04 CA CA2748760A patent/CA2748760C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10241137A1 (de) * | 2002-09-03 | 2004-03-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Metallisierung von Kunststoffen |
| CN1986003A (zh) * | 2005-12-23 | 2007-06-27 | 中国科学院金属研究所 | 一种钛或钛合金表面生物活性涂层及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010203260B9 (en) | 2013-10-31 |
| CA2748760C (en) | 2015-07-21 |
| AU2010203260B2 (en) | 2013-10-17 |
| US8828552B2 (en) | 2014-09-09 |
| ES2376539T3 (es) | 2012-03-14 |
| AU2010203260A1 (en) | 2011-07-14 |
| US20120024712A1 (en) | 2012-02-02 |
| JP2012514483A (ja) | 2012-06-28 |
| EP2204199A1 (de) | 2010-07-07 |
| JP5647145B2 (ja) | 2014-12-24 |
| CA2748760A1 (en) | 2010-07-08 |
| EP2204199B1 (de) | 2011-10-26 |
| ATE530205T1 (de) | 2011-11-15 |
| WO2010076338A1 (de) | 2010-07-08 |
| CN102271721A (zh) | 2011-12-07 |
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |