WO2010059742A1 - Individualized cancer treatment - Google Patents

Individualized cancer treatment Download PDF

Info

Publication number
WO2010059742A1
WO2010059742A1 PCT/US2009/065011 US2009065011W WO2010059742A1 WO 2010059742 A1 WO2010059742 A1 WO 2010059742A1 US 2009065011 W US2009065011 W US 2009065011W WO 2010059742 A1 WO2010059742 A1 WO 2010059742A1
Authority
WO
WIPO (PCT)
Prior art keywords
genes
cell
cellular
development
cancer
Prior art date
Application number
PCT/US2009/065011
Other languages
English (en)
French (fr)
Inventor
Raphael Lehrer
Robert Coopersmith
Original Assignee
Collabrx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Collabrx, Inc. filed Critical Collabrx, Inc.
Priority to EP09759850A priority Critical patent/EP2366162A1/de
Publication of WO2010059742A1 publication Critical patent/WO2010059742A1/en
Priority to IL212905A priority patent/IL212905A0/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PCT/US2009/065011 2008-11-18 2009-11-18 Individualized cancer treatment WO2010059742A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP09759850A EP2366162A1 (de) 2008-11-18 2009-11-18 Individualisierte krebsbehandlung
IL212905A IL212905A0 (en) 2008-11-18 2011-05-16 Individualized cancer dignosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11589808P 2008-11-18 2008-11-18
US61/115,898 2008-11-18

Publications (1)

Publication Number Publication Date
WO2010059742A1 true WO2010059742A1 (en) 2010-05-27

Family

ID=41683176

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/065011 WO2010059742A1 (en) 2008-11-18 2009-11-18 Individualized cancer treatment

Country Status (4)

Country Link
US (1) US10262103B2 (de)
EP (1) EP2366162A1 (de)
IL (1) IL212905A0 (de)
WO (1) WO2010059742A1 (de)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102183655A (zh) * 2011-01-24 2011-09-14 中国人民解放军军事医学科学院生物医学分析中心 用于乳腺癌内分泌治疗预后判断的新的分子标志物cuedc2蛋白质
CN102269766A (zh) * 2010-06-01 2011-12-07 北京大学 人类基因fam96a及其蛋白质的应用
US20120238464A1 (en) * 2011-03-18 2012-09-20 Baylor Research Institute Biomarkers for Predicting the Recurrence of Colorectal Cancer Metastasis
CN102772803A (zh) * 2011-05-12 2012-11-14 北京大学 Unc5cl及其编码蛋白的应用
US8426418B2 (en) 2010-08-27 2013-04-23 CollabRx Inc. Method to treat melanoma in BRAF inhibitor-resistant subjects
CN103146821A (zh) * 2013-02-25 2013-06-12 安徽农业大学 一种snp位点对性状遗传效应的评价方法及应用
WO2017073971A1 (ko) * 2015-10-28 2017-05-04 숙명여자대학교산학협력단 Anks1a 단백질 발현 또는 활성 억제제를 유효성분으로 포함하는 암 예방 또는 치료용 조성물 및 이의 스크리닝 방법
US9850543B2 (en) 2013-03-15 2017-12-26 Novartis Ag Biomarkers associated with BRM inhibition
CN108841960A (zh) * 2018-07-12 2018-11-20 吉林大学 一种结肠腺癌易感性预测试剂盒及系统
CN112812179A (zh) * 2021-01-19 2021-05-18 北京大学 高亲和力高特异性抗cmtm6单克隆抗体及其用途

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499864B2 (en) 2003-11-03 2016-11-22 Aab Patent Holding Aps Expression of FABP4 and other genes associated with bladder cancer progression
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
US20130143747A1 (en) * 2011-12-05 2013-06-06 Myriad Genetics, Incorporated Methods of detecting cancer
WO2011060080A2 (en) * 2009-11-10 2011-05-19 Gema Diagnostics, Inc. Genes differentially expressed by cumulus cells and assays using same to identify pregnancy competent oocytes
CA3007713C (en) 2010-04-29 2020-05-26 The Regents Of The University Of California Pathway recognition algorithm using data integration on genomic models (paradigm)
US10192641B2 (en) 2010-04-29 2019-01-29 The Regents Of The University Of California Method of generating a dynamic pathway map
US20130116150A1 (en) 2010-07-09 2013-05-09 Somalogic, Inc. Lung Cancer Biomarkers and Uses Thereof
SG2014007454A (en) 2010-08-13 2014-07-30 Somalogic Inc Pancreatic cancer biomarkers and uses thereof
US9309556B2 (en) 2010-09-24 2016-04-12 The Board Of Trustees Of The Leland Stanford Junior University Direct capture, amplification and sequencing of target DNA using immobilized primers
AU2011312491B2 (en) * 2010-09-27 2015-06-04 Somalogic, Inc. Mesothelioma biomarkers and uses thereof
NZ589251A (en) 2010-11-12 2014-07-25 Pacific Edge Ltd Novel marker for detection of bladder cancer
KR101371697B1 (ko) * 2011-02-07 2014-03-07 연세대학교 원주산학협력단 환자 맞춤형 암 치료
WO2012174378A2 (en) 2011-06-17 2012-12-20 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
SG2014012728A (en) 2011-08-23 2014-06-27 Foundation Medicine Inc Novel kif5b-ret fusion molecules and uses thereof
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
US20130144584A1 (en) * 2011-12-03 2013-06-06 Medeolinx, LLC Network modeling for drug toxicity prediction
WO2013132440A1 (en) * 2012-03-07 2013-09-12 Manuel Gidekel Tumor biomarkers for pancreatic cancer
EP2861766B1 (de) * 2012-06-13 2018-08-08 King Abdullah University Of Science And Technology Methylierungsbiomarker für brustkrebs
WO2014038884A1 (ko) * 2012-09-07 2014-03-13 주식회사 마크로젠 융합 단백질 및 이를 포함하는 암 진단용 조성물
WO2014043628A1 (en) * 2012-09-14 2014-03-20 Memorial Sloan-Kettering Cancer Center Genes associated with dasatinib sensitivity
WO2014071316A1 (en) * 2012-11-02 2014-05-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. In silico identification of cancer molecular signaling pathways and drug candidates
WO2014113204A1 (en) 2013-01-17 2014-07-24 Personalis, Inc. Methods and systems for genetic analysis
WO2014152377A1 (en) * 2013-03-14 2014-09-25 Vanderbilt University Methods for classifying and treating adenocarcinomas
EP2971129B1 (de) 2013-03-15 2018-05-09 Sutter Bay Hospitals Falz zur verwendung als target für therapien zur behandlung von krebs
US10968484B2 (en) 2013-03-15 2021-04-06 The Broad Institute, Inc. Methods of identifying responses to map kinase inhibition therapy
RU2528247C2 (ru) * 2013-05-07 2014-09-10 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Способ оценки чувствительности клеток рака легкого к доксорубицину на основании уровней экспрессии маркерных генов и набор для его осуществления
WO2014189832A1 (en) * 2013-05-22 2014-11-27 Albert Einstein College Of Medicine Of Yeshiva University Il-34 receptor assays and uses thereof
DK3039424T3 (da) * 2013-08-28 2020-08-31 Crown Bioscience Inc Taicang Genekspressionssignaturer, der er prædiktive for et individs respons på en multikinaseinhibitor, og fremgangsmåder til anvendelse af disse
EP3965111A1 (de) 2013-08-30 2022-03-09 Personalis, Inc. Verfahren und system zur genomanalyse
CN103525916B (zh) * 2013-09-24 2016-06-15 浙江大学医学院附属第四医院 评估肝细胞癌预后的试剂盒及rffl的应用
GB2535066A (en) 2013-10-03 2016-08-10 Personalis Inc Methods for analyzing genotypes
WO2015061348A1 (en) * 2013-10-21 2015-04-30 Memorial Sloan-Kettering Cancer Center Atrx as a companion diagnostic for cdk4 inhibitors
US20170002421A1 (en) * 2013-12-23 2017-01-05 The General Hospital Corporation Methods and assays for determining reduced brca1 pathway function in a cancer cell
US20170003292A1 (en) * 2014-03-13 2017-01-05 H. Lee Moffitt Cancer Center And Research Institut Inc. Paxip1 as a biomarker for wee1 inhibitor therapy
US20150269307A1 (en) * 2014-03-18 2015-09-24 Texas Tech University System Target inhibition map system for combination therapy design and methods of using same
CN103969452B (zh) * 2014-05-30 2016-04-20 中国人民解放军第二军医大学 索拉菲尼个性化治疗肝癌的分型诊断试剂盒
CN106415560A (zh) * 2014-06-25 2017-02-15 皇家飞利浦有限公司 辅助患者和临床医师使用共享并且以患者为中心的决策支持工具的系统和方法
US20170283882A1 (en) * 2014-09-05 2017-10-05 Duke University Methods and therapeutics relating to mrna biomarkers for clinical prognosis of cancer
WO2016070131A1 (en) 2014-10-30 2016-05-06 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
MA48487B1 (fr) * 2014-12-23 2021-11-30 Immatics Biotechnologies Gmbh Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers
JP2018523823A (ja) * 2015-08-04 2018-08-23 セルジーン コーポレイション 慢性リンパ球性白血病の治療方法及び免疫調節療法に対する臨床的感度の予測因子としてのバイオマーカーの利用
US10720227B2 (en) 2015-08-12 2020-07-21 Samsung Electronics Co., Ltd. Method and device for mutation prioritization for personalized therapy
CN105483226B (zh) * 2015-12-21 2018-06-19 中国人民解放军第三军医大学第三附属医院 一种检测strap基因转录水平的方法及试剂盒
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
CN110234769A (zh) * 2016-12-01 2019-09-13 牛津生物动力有限公司 表观遗传染色体相互作用在癌症诊断中的应用
EP3568864A1 (de) * 2017-01-11 2019-11-20 Koninklijke Philips N.V. Verfahren und system zur automatischen erkennung von ein- oder ausschlusskriterien
CN106729756B (zh) * 2017-02-28 2021-05-25 青岛泱深生物医药有限公司 生物标志物作为靶标在肺腺癌诊治中的应用
CN108732349A (zh) * 2017-04-20 2018-11-02 中国科学院上海生命科学研究院 Lta4h作为指示肝内结节及早期预警肝癌的生物标志物
CN108732350A (zh) * 2017-04-20 2018-11-02 中国科学院上海生命科学研究院 Pla2g6作为指示肝内结节及早期预警肝癌的生物标志物
CN108732351A (zh) * 2017-04-20 2018-11-02 中国科学院上海生命科学研究院 Eps8l2作为指示肝内结节及早期预警肝癌的生物标志物
CN107881231A (zh) * 2017-10-18 2018-04-06 中国人民解放军兰州军区兰州总医院 Lmo3基因在制备胶质瘤抗肿瘤药物中的应用
US20190249229A1 (en) * 2018-02-12 2019-08-15 Nant Holdings Ip, Llc Bam signatures from liquid and solid tumors and uses therefor
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US20210308171A1 (en) * 2018-08-07 2021-10-07 The Broad Institute, Inc. Methods for combinatorial screening and use of therapeutic targets thereof
CN110343759A (zh) * 2019-06-03 2019-10-18 张鹏 Trpv4的用途及其抑制剂的用途和药物筛选方法
CN110423812B (zh) * 2019-07-02 2023-07-25 南方医科大学 Skiv2l2（MTR4）基因在肿瘤治疗中的用途
CN110687284B (zh) * 2019-08-26 2023-05-23 中国医学科学院肿瘤医院 检测血清中six2自身抗体的试剂的应用
CN110687283B (zh) * 2019-08-26 2023-05-23 中国医学科学院肿瘤医院 自身抗体在诊断和/或治疗肿瘤中的应用
CN110596403B (zh) * 2019-09-17 2022-12-16 中山大学附属第一医院 用于卵巢癌诊断的特异性蛋白标记物及制备方法
WO2021155192A1 (en) * 2020-01-30 2021-08-05 Thomas Jefferson University Compositions and methods of using cyanine dyes to target cancer and mitochondria
CN114277137B (zh) * 2020-03-30 2022-09-02 中国医学科学院肿瘤医院 外泌体arpc5、hmgn1等在肺癌诊断中的应用
IT202000028628A1 (it) * 2020-11-26 2022-05-26 Ceinge Biotecnologie Avanzate S C A R L Metodo per prevedere la formazione di metastasi in pazienti tumorali
KR102505355B1 (ko) * 2021-04-16 2023-03-02 울산과학기술원 Thrap3 및 ddx5의 결합을 이용한 암 치료제 스크리닝 방법
CN113652486B (zh) * 2021-09-13 2023-02-03 新疆医科大学第四附属医院 结直肠癌治疗预后生物标志物及其应用
CN114277136B (zh) * 2021-12-07 2023-09-22 武汉瑟文生物科技有限公司 一种基于ecDNA上的肺癌基因标志物及其应用
US20240095273A1 (en) * 2022-09-16 2024-03-21 Google Llc Actionable suggestions for media content
CN116482367A (zh) * 2023-05-04 2023-07-25 中国中医科学院望京医院(中国中医科学院骨伤科研究所) 一种联合mSEPT9检测和生物标志物的结直肠癌检测方法
CN117192127A (zh) * 2023-08-18 2023-12-08 肇庆医学高等专科学校 一种hcc治疗靶点的发现方法
CN117305452B (zh) * 2023-09-27 2024-05-03 山东大学第二医院 人SNRK mRNA在非小细胞肺癌诊断、靶向治疗和预后评估中的应用及试剂盒
CN117567651B (zh) * 2024-01-15 2024-03-26 中国人民解放军东部战区总医院 协同表达血管内皮黏附分子vcam1的嵌合抗原受体及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040197774A1 (en) * 1992-11-12 2004-10-07 Michael Wigler Representational approach to DNA analysis
US5436142A (en) * 1992-11-12 1995-07-25 Cold Spring Harbor Laboratory Methods for producing probes capable of distingushing variant genomic sequences
US20030224464A1 (en) * 2002-01-31 2003-12-04 Baylor College Of Medicine Secreted caveolin as a marker for prostate cancer
US20070172844A1 (en) * 2005-09-28 2007-07-26 University Of South Florida Individualized cancer treatments

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARRA ET AL: "Robust segmentation and analysis of DNA microarray spots using an adaptative split and merge algorithm", COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, ELSEVIER, AMSTERDAM, NL, vol. 81, no. 2, 1 February 2006 (2006-02-01), pages 174 - 180, XP024895754, ISSN: 0169-2607, [retrieved on 20060201] *
WULFKUHLE J ET AL: "Genomic and proteomic technologies for individualisation and improvement of cancer treatment", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, vol. 40, no. 17, 1 November 2004 (2004-11-01), pages 2623 - 2632, XP004646472, ISSN: 0959-8049 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102269766A (zh) * 2010-06-01 2011-12-07 北京大学 人类基因fam96a及其蛋白质的应用
CN102269766B (zh) * 2010-06-01 2015-08-26 北京大学 人类基因fam96a及其蛋白质的应用
US8426418B2 (en) 2010-08-27 2013-04-23 CollabRx Inc. Method to treat melanoma in BRAF inhibitor-resistant subjects
CN102183655A (zh) * 2011-01-24 2011-09-14 中国人民解放军军事医学科学院生物医学分析中心 用于乳腺癌内分泌治疗预后判断的新的分子标志物cuedc2蛋白质
US20120238464A1 (en) * 2011-03-18 2012-09-20 Baylor Research Institute Biomarkers for Predicting the Recurrence of Colorectal Cancer Metastasis
CN102772803A (zh) * 2011-05-12 2012-11-14 北京大学 Unc5cl及其编码蛋白的应用
CN103146821B (zh) * 2013-02-25 2015-06-17 安徽农业大学 一种snp位点对性状遗传效应的评价方法及应用
CN103146821A (zh) * 2013-02-25 2013-06-12 安徽农业大学 一种snp位点对性状遗传效应的评价方法及应用
US9850543B2 (en) 2013-03-15 2017-12-26 Novartis Ag Biomarkers associated with BRM inhibition
WO2017073971A1 (ko) * 2015-10-28 2017-05-04 숙명여자대학교산학협력단 Anks1a 단백질 발현 또는 활성 억제제를 유효성분으로 포함하는 암 예방 또는 치료용 조성물 및 이의 스크리닝 방법
CN108841960A (zh) * 2018-07-12 2018-11-20 吉林大学 一种结肠腺癌易感性预测试剂盒及系统
CN108841960B (zh) * 2018-07-12 2022-02-01 吉林大学 一种结肠腺癌易感性预测试剂盒及系统
CN112812179A (zh) * 2021-01-19 2021-05-18 北京大学 高亲和力高特异性抗cmtm6单克隆抗体及其用途
CN112812179B (zh) * 2021-01-19 2022-07-22 北京大学 高亲和力高特异性抗cmtm6单克隆抗体及其用途

Also Published As

Publication number Publication date
US20100130527A1 (en) 2010-05-27
EP2366162A1 (de) 2011-09-21
US10262103B2 (en) 2019-04-16
IL212905A0 (en) 2011-07-31

Similar Documents

Publication Publication Date Title
US10262103B2 (en) Individualized cancer treatment
US20210104321A1 (en) Machine learning disease prediction and treatment prioritization
US10870888B2 (en) Methods and systems for analysis of organ transplantation
US20240102095A1 (en) Methods for profiling and quantitating cell-free rna
US11401552B2 (en) Methods of identifying male fertility status and embryo quality
CN110499364A (zh) 一种用于检测扩展型遗传病全外显子的探针组及其试剂盒和应用
US11610646B2 (en) Methods, systems and processes of identifying genetic variation in highly similar genes
WO2019079647A2 (en) IA STATISTICS FOR DEEP LEARNING AND PROBABILISTIC PROGRAMMING, ADVANCED, IN BIOSCIENCES
WO2016004387A1 (en) Gene expression signature for cancer prognosis
WO2008086182A2 (en) Use of gene signatures to design novel cancer treatment regimens
WO2012031008A2 (en) Cancer-related biological materials in microvesicles
AU2010326066A1 (en) Classification of cancers
WO2019008412A1 (en) USE OF BLOOD GENE EXPRESSION ANALYSIS FOR CANCER CARE
CN103890193A (zh) 用于确定吸烟状态的方法和组合物
WO2019008415A1 (en) EXOSOMED AND PBMC GENE EXPRESSION ANALYSIS FOR CANCER CARE
WO2019008414A1 (en) GENE EXPRESSION ANALYSIS BASED ON EXOSOMES FOR THE CARE OF CANCER
KR20200044677A (ko) 암 약물 반응성 판단을 위한 바이오 마커, 이를 이용한 암 약물 반응성 판단 방법 및 이를 위한 암 약물 반응성 진단칩
CA3178405A1 (en) Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus
WO2014162008A2 (en) Novel biomarker signature and uses thereof
WO2023091587A1 (en) Systems and methods for targeting covid-19 therapies
US20230220470A1 (en) Methods and systems for analyzing targetable pathologic processes in covid-19 via gene expression analysis
KR20200044682A (ko) Igfr 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 igfr 약물 반응성 판단 방법 및 igfr 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
Wong et al. Evolution of network biomarkers from early to late stage bladder cancer samples
US20210193267A1 (en) Methods, systems, and related computer program products for evaluating cancer model fidelity
Almeida Molecular diagnosis of autism spectrum disorder through whole exome sequencing

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09759850

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 212905

Country of ref document: IL

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 4676/DELNP/2011

Country of ref document: IN

Ref document number: 2009759850

Country of ref document: EP