KR20200044677A - 암 약물 반응성 판단을 위한 바이오 마커, 이를 이용한 암 약물 반응성 판단 방법 및 이를 위한 암 약물 반응성 진단칩 - Google Patents

Abstract

본 발명은 암을 포함하는 질병 관련 특이 유전자 변이 지문 (Genetic Variation Fingerprints)을 기능정보를 가진 하플로타입으로 변형 후 약물의 분자 프로파일의 결합분석에 의해 약물의 반응성을 신뢰성 있게 예측할 수 있는 새로운 학습모델인 약물 적응증 및 반응 예측 시스템 및 방법인 GBLscan(Genetic biomarker Labeling Scan)에 관한 것으로, 본 발명은 수집된 학습정보로부터 유전체에 포함된 유전정보에 대한 약물을 구성하는 구성정보의 반응성 상관관계를 선형 희귀 및 딥러닝 기계학습에 의해 학습하는 학습모듈과; 분석정보를 수신하여 상기 분석정보에 포함된 유전체에 대한 약물의 반응성 예측결과를 산출하는 예측모듈과; 상기 학습모듈에 의해 학습된 반응성 예측알고리즘을 저장하는 저장모듈을 포함하여 구성되고: 상기 학습정보는, 생체 외 세포주 및 생체 내 임상연구에 대한 약물의 반응성 정보이다. 이와 같은 본 발명에 의하면, 본 발명에서는 임상시험으로부터 수집되는 유전체에 대한 약물의 반응성 결과들로부터, 약리 효과가 밝혀지지 않은 유전체와 약물의 반응성 정도를 예측할 수 있는 효과가 있다.

Description

암 약물 반응성 판단을 위한 바이오 마커, 이를 이용한 암 약물 반응성 판단 방법 및 이를 위한 암 약물 반응성 진단칩 { Bio-Marker for Prediction of Drug Sensitivity, Estimation Method for Prediction of Drug Sensitivity and Diagnosing Chip for Prediction of Drug Sensitivity }

본 발명은 암약물반응성 및 유전자발현정보 및 복제수변이(CNV)를 이용한 기능 정보를 포함하는 하플로타입(haplotype) 바이오마커를 예측하여, 암 약물 반응성을 신뢰성 있게 예측 및 약 레이블링을 할 수 있게 하는 새로운 학습 모델인 GBLscan (Cancer Biomarker Labeling Scan)에 관한 것으로, 본 특허는　중소벤처기업부에서 지원하는 2018년도 산학연협력 기술개발사업(No.S2634294)의 연구수행 결과물을 포함한다.

최근에 차세대시퀀싱 (NGS, next generation sequencing) 기술의 혁신으로 복잡하고 다양한 암을 이해하는데 많은 발전이 이루어졌다. 또한, 국제적인 컨소시엄의 노력으로 이러한 암 종의 체세포 돌연변이에 대한 카탈로그뿐만 아니라 총체적인 암 유발 돌연변이(driver mutation) 데이터베이스도 개발 및 발표되었다[선행기술문헌 001, 002 및 003 참조].

이러한 국제적인 컨소시엄 연구 성과로 인해서 개별 종양의 특정 유전체 지문(genomic fingerprint)에 대한 암 맞춤치료에 대한기대 또한 급속도로 커지게 되었다.

그러나 현재 암 환자 및 제약업계를 포함한 의료계의 모든 이해 관계자들에게 임상에서 승인되고 사용되는 새로운 맞춤 암 치료제는 여전히 충분하지 않은 실정이다[선행기술문헌 004 참조]. 따라서, 유전체정보와 항암제의 반응 사이의 개인 맞춤을 위한 연관성을 예측하기 위한 효율적이고 체계적인 접근이 필요하게 되었다.

그리고 암 세포주 및 약물 독성 데이터의 분자 프로파일링 데이터를 통합하기 위해 여러 가지 협력 컨소시엄이 이루어졌다[www.lincsproject.org, 선행기술문헌 005 및 006 참조]. 이러한 컨소시엄은 항암제 독성 및 개인에 특화된 맞춤 약물을 예측할 수 있는 유전체 바이오마커 (biomarker)를 밝히는 것이 가장 중요한 목표이다.

암에서의 약물 독성을 위한 세포주 유전체 DB중에서 GDSC (GDSC, Genomics of Drug Sensitivity in Cancer)는 공개적으로 이용 가능한 데이터베이스의 한 예이다. 특히, GDSC는 265개의 항암 화합물에 대하여 1,070 개의 인간 암세포의 약물 독성 정보를 실험적으로 측정한 공용 데이터베이스이다[선행기술문헌 006 참조].

여기서 사용된 GDSC의 세포주 프로젝트는 다음의 사이트에서 공개되었다 (CCLP: COSMIC Cell Lines Project, http://cancer.sanger.ac.uk/cell_lines). 이러한 공용 자원은 유전체 기반 정밀 암 치료제 실현에 큰 도움이 될것으로 기대된다.

그러나 이러한 데이터베이스의 잠재적인 가치에도 불구하고 높은 차원의 데이터와 복잡성으로 인해 통합 분석에는 많은 기술적인 문제가 존재한다. 따라서, 항암 약물 독성에서 분자 바이오마커를 체계적으로 규명하기 위한 많은 계산방법이 개발되었지만[선행기술문헌 005, 007, 008, 009, 010, 011, 012, 013 참조], 이러한 노력에도 불구하고 약물 독성은 특정 세포주 및 주어진 유전자 변이 세트에 제한되는데, 이는 모든 사람의 유전정보는 모두 다르고, 공통적인 변이는 전체에서 일부분이기 때문이다.

정보 기술의 최근 발전으로 앞에서 언급한 복잡한 문제를 해결하기 위해 점점 더 많이 사용되는 방법이 딥러닝 모델(deep learning model) 또는 심층학습 모델이라 부른다[선행기술문헌 014 참조]. 딥러닝 학습 방법은 대량의 고차원 원시 데이터로부터 심층 기계 학습을 하는 기술의 한 분야이다[선행기술문헌 015 참조].

최근까지는 학습을 하기에 계산 양의 한계로 직접적으로 많은 제한이 있었지만[선행기술문헌 016 참조]. 그러나 방법론적 개선과 병렬 컴퓨팅에 의한 강력한 기계를 사용하면서 수천 개의 숨겨진 유닛을 포함하는 다양한 레이어로 딥러닝 학습 모델을 교육할 수 있게 되었다[선행기술문헌 017, 018, 019, 020 참조].

한편, 약리적, 유전체, 전사체 및 후성유전체 데이터와 그들의 약물반응성 데이터와 같은 여러 유형의 구조 정보를 조작할 수 있기 때문에 최소한의 지침으로 약물-표적 상호 작용 예측에 적합하게 되었다[선행기술문헌 014 참조].

제약 업계는 신약 개발을 위해 이러한 유형의 데이터를 활용하는 딥러닝 학습에 많은 기대감을 보여주기 시작했다[선행기술문헌 021 참조]. 최근에는 약물 개발에서 인공 지능을 사용하여 몇 가지 유망한 결과가 입증되었고[선행기술문헌 022, 023, 024, 025 참조], 약물-표적 프로파일 및 다른 전통적인 기계 학습 모델에 비해 우수한 예측 정확도를 갖는 약물 재사용(drug repositioning)도 가능해졌다[선행기술문헌 026 및 027 참조]. 그러나 대다수의 접근방법은 오히려 개념 증명에 그쳤고, 딥러닝 학습을 통한 약물 발견의 생산 가능 솔루션은 부족한 현실이다[선행기술문헌 028 참조].

현재 PubChem(pubchem.ncbi.nlm.nih.gov)은 미국 NCBI(국립기술정보센터)에서 운영하고 있고, 약 1억개 화합물(compounds), 2억 개의 물질(substances) 및 바이오에세이(bioassay)정보를 보유하고 있다(en.wikipedia.org/wiki/PubChem).

또한, 이러한 화합물(compound)은 약리적 작용기(pharmacophore descriptor)로 표현하는 많은 방법들이 존재한다[선행기술문헌 029, 030, 031, 032 및 033 참조]. 그 중에서 파델(PaDELL) 방법은 약물에서 1,875 (1D 및 2D 1,444개, 그리고 3D 431개) 특징(feature) 및 12개의 지문(전체 약 16,092 비트)으로 표현할 수 있다[선행기술문헌 029 참조].

그리고 유전체에서 변이는 다양한 특징들을 추출할 수 있다. 특히, 질병원인 변이를 추출하는 종래의 방법 및 툴 들은 선행기술문헌 034 내지 056에 개시된 바 있다.

따라서, 종래기술은 개별적으로 QSAR(Quantitative structureactivity relationship), 약물 세포독성 데이터를 사용한 약물개발, 딥러닝 (Deep Learning)기반 전장유전체(whole genome sequencing)의 발현조절, 구조적 변이 등이 독립적으로 적용되어 활용되었다.

그러나 본 발명에서는 약물(drugs)-세포(cell lines)-독성(IC50) 데이터에 이종 특성정보(유전체정보, QSAR정보 및 발현정보)를 통합한 AI 딥러닝 방법인 CDRscan(Cancer drug response scanning)은 예측 정확도가 이전 컴퓨터 모델링 접근법과 비교하여 현저히 향상되었고, 특히, 버추얼 약물(drugs) vs. 버추얼 세포(cell lines) 혹은 표적단백질의 상호작용 모델을 제안한 바 있다.

여기서, 2개의 다른 이종 특성 버추얼 정보는 첫 번째가 약물인 경우, 파델(PaDELL) 방법 혹은 선행기술문헌 029 내지 033에 개시된 방법 들이 적용될 수 있다.

그리고 두 번째는 전장 유전체(혹은 표적 단백질)의 지문(Genomic fingerprint, or a set of mutation features)에 대한 문헌방법[선행기술문헌 034 내지 056 참조]으로 설명이 될 수 있고, 가장 표준적인 딥러닝 방법은 선행기술문헌 057에 개시된 바와 같다.

따라서 본 방법은 정확한 약물반응 예측모델 및 약물 재사용/재배치(drug repositioning), 화학 물질의 스크리닝 및 새로운 항암제 후보 발굴 및 환자 맞춤형 항암제 선택을 위한 임상의사결정지원시스템(Clinical decision supporting system) 에 사용될 수 있다.

그리고 최근에 재사용/재배치 (drug repositioning)관련 암약물반응스켄(CDRscan) 논문이 본사에 의하여 출판이 되었다[선행기술문헌 058 참조].

즉, 유전자발현 및 시스템적 통계적인 방식으로 주어진 약물 및 표적유전자 약 그리고 표적 후보유전자들의 발현정보 및 바이오마커 정보를 활용한 약물반응성 연구가 최근에 발표되었다.

본 논문에서는 바이오마커 자체에 대한 연구는 없었지만, 알려진 유전자 바이오마커 및 발현정보를 활용하여 주요표적에 대한 주요 약물 몇 개에 대하여 저해 능력(inhibition)을 CCLE(Cancer Cell Line Encyclopedia), CTRP(Cancer Therapeutics Response Portal, Broad) 및 일부 GDSC를 활용하여 예측(CARE)하고 검증하는 결과를 보여주었다[선행기술문헌 059 참조].

또한, eQTL (expression and Quantitative Trait Loci), 즉 발현과 유전체 변이간의 질병 혹은 표현형 연관관계에 대한 주요 연구가 많이 발표되었다[선행기술문헌 060 참조]. 그리고, pQTL (protein and Quantitative Trait Loci), 즉 단백질 생성과 유전체 변이간의 질병 혹은 표현형 연관관계에 대한 주요 연구 역시 많이 발표되었다[선행기술문헌 061 참조].

그러나 cQTL (Copy Number Variation and Quantitative Trait Loci), 즉 약물반응성 및 유전자 복제수 증가 혹은 감소 변이인 CNV(copy number variation)와 유전체 변이간의 약물반응 혹은 약물 표현형 연관관계에 대한 연구는 아직까지 발표된 적이 없다.

따라서, 본 GBLscan(genetic biomarker label scan)방법에서는 (a) eQTL (expression and Quantitative Trait Loci), 즉 발현과 유전체 변이간의 질병 혹은 표현형 연관관계, (b) cQTL (Copy Number Variation and Quantitative Trait Loci), 즉 유전자 복제 수 변이(copy amplification) 및 감소 (copy deletion)과의 연관관계는 아직 참고문헌이 존재하지 않는다.

본 발명에서 약물타입(DrugClass)에 대한 정의는 약물 표적들의 타입(type) 및 약물의 관능기적 유사한 기능 타입, 혹은, 약물이 영향을 주는 범주의 유전자그룹, 약물 패스웨이(drug pathway) 혹은 약물 시그널링 패스웨이(drug signaling pathway), 등은 모두 하나의 통칭 약물타입(DrugClass)로 설명을 한다. 또한, 기능하플로타입은 일반적으로 사용하는 하플로타입인 유전자에서 페이싱(phasing)이 된 여러개의 로커스 (locus)들에 대한 반수체(haplotype)과 달리, 본 발명에서는 인간유전체 버전인 Dec. 2013 (GRCh38/hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https ://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 를 기반으로 차세대 시퀀싱 리드(read) 데이터를 정렬을 하게 되면, 각 유전자 로커스에서 지노타입 형태로 정보가 읽히게 된다. 이러한 지노타입형태는 1:homo, 2:hetero 혹은 3: alt home형태로 표현 되는데, 그러한 지노타입의 모음을 상대 하프로타입 이라고 할 수 있다. 그리고, 특정 로커스의 단일 혹은 조합으로 구성된 상대 하플로타입이 특정 유전자의 발현과 연관이 있다면 이것을 기능하프로타입 이라고 본 발명에서 정의한다.

한편, 아래 첨부된 비 특허 선행기술 문헌을 주요 내용별로 구분하면, 비특허문헌,

(001 - 004)은 유전체 정보와 항암제의 반응 사이의 연관성 논문이고;

(005 - 013)은 암 유전체 약물독성 및 COSMIC 세포주 프로젝트 문헌이며;

(014 - 018)은 딥러닝 심층학습 모델의 약리학 및 유전체관련 논문이고;

(019 - 028)은 딥러닝 심층학습 모델의 신약 개발에 사용된 논문이고;

(029 - 056)은 약물 및 변이를 특징(feature)으로 표현하는 방법 및 논문이고;

(057 - 058)은 딥러닝 방법론 및 알고리즘에 대한 논문이고;

(059 - 059)은 약물 재창출 혹은 약물반응성 예측 논문이고,

(060 - 061)은 eQTL 및 pQTL 방법론 및 알고리즘에 대한 논문이다.

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본 발명은 상기와 같은 종래의 문제점을 해결하기 위하여 안출된 것으로, 본 발명은 전술한 바와 같은 기술배경 및 사회적 요구에 따라, 암 약물의 반응성을 반응 대상 유전체의 유전특성 및 지문을 기능성 정보를 가진 하플로타입으로 변환하여 높은 정밀도의 약물 적응증 및 민감성 예측 시스템을 제공하기 위한 것으로, 본 발명의 구체적인 목적은, 공지된 비-임상용 세포주 유전체, 그것 들의 유전자 발현정보 및 유전자 복제수변이, 그리고 생체내 약물반응과 관련을 양적형질위치(QTL: quantitative trait loci)들의 모음(기능성 하플로타입) 정보기반 선형 회귀 모델링 및 딥러닝 기계학습을 신뢰성 있게 예측할 수 있는 예측 시스템을 제공하기 위한 것이다.

그리고 본 발명에서는 본 발명에 의한 GBLscan방법에 의해 유전자 RNA발현 및 복제수변이(CNV)와 상관관계가 높은 양적 형질 위치 (QTL)들을 수집하여 기능정보를 가진 다중변이기반 하플로타입을 생성하고 약물 민감성 및 반응성을 효과적으로 필터링하는 가상임상(In Silico Clinical Trial)을 위한 약물 반응성을 예측하는 방법을 제공하기 위한 것이다.

상기한 바와 같은 목적을 달성하기 위한 본 발명의 특징에 따르면, 본 발명은 검사 대상 양적형질 위치(QTL)들의 위치 모음 생성하는 단계와; 기능 하플로타입(FRH)과 약물반응 상관관계 계산하는 단계와; 그리고, 기능 하플로타입기반 약물반응 예측모델 생성하는 단계로 구성된다.

우선, 양적형질 위치 (QTL)들의 위치 모음 생성하기 위한 제1단계에서는; 기능 연관 하플로타입(FRH)과 약물반응성 상관관계 계산을 수행하기 위하여, (A) 약 1,000개의 세포주에서 약 4백만 변이와 약 20,000 유전자 발현 상관관계 계산하고, 그리고, (B) 약물(265개)과 1,000개 셀라인 유전체의 각 20,000여개 유전자발현 및 유전자 복제수변이 들과의 상관관계 계산한다.

이때, (A)단계 및 (B)단계는 공통 변수로 유전자 발현 및 유전자 복제수변이들을 모두 포함하는데, 이러한 공통변수인 유전자발현 정보를 활용하여 약물반응에 영향을 주는, 다중 혹은 단일변이와 연관을 가진 변이를 수집한다. 이것을 양적형질 위치 (QTL)들의 위치 모음이라고 한다.

그리고 유전체통합 DB에서 각 세포주 유전체에서 단일 및 다중변이정보를 수집하여 기능 하플로타입을 만들고 동일 세포주에서 약물반응성 정보와 함께 추출하고, 이러한 기능 하플로타입 들을 기능 하플로타입, FRH(Functionally relevant haplotope)으로 정의하고, FRH를 해시넘버 (hash number)로 표현 한다.

그리고 제2단계에서는, 기능하플로타입(FRH)과 약물반응 상관관계 계산하기 위하여, 하플로타입(FRH)를 해시넘버(hash number)로 변한하고, 변환된 해시넘버를 사용하여 약물반응성정보와 조합 상관관계 테스트(Pairwise Pearson Test)를 수행하고, 이를 모든 암 종에서 위의 작업을 반복 한다.

기능하플로타입기반 약물반응 예측모델 생성하는 제3단계에서는, 특정 암에서 약물 패스웨이(drug pathway)기반 약물반응 예측모델 생성관련 과정을 다음과 같이 수행한다.

(1) 기능연관 하플로타입과 특정 암 및 특정약물 패스웨이(Drug Pathway)와 관련된 각 약물과 상관관계를 계산하고, (2) 기능하플로타입 및 약물반응성 상관관계 메트릭스에서 X축 및 Y축의 상관관계 정보를 클러스터링을 하며, (3) 각 예측모델에서 유의성(p-value)이 높은 것을 수집하여 모델에 상호작용 기능을 모델에 적용하여 선형 회귀 모델을 계산한다, 그리고, 마지막으로 (4) NGS 데이터를 입력으로 하여 약물반응성과 연관을 가진 기능하플로타입를 계산하고 선형 회귀 모델을 사용하여 약물반응성을 예측한다.

그리고 본 발명은, 전술한 바와 같은 기능 하플로타입 정보를 활용하여 약물반응성 예측 모델을 계산하기 위해, 검사 대상 유전체로부터 수집된 염기서열에서 다수의 변이들을 활용하여 기능 하플로타입 들을 계산하는 단계와: 선형 회귀 모델의 해를 계산하는 단계와; 이러한 해를 이용하여 암약물 중에 민감성이 높은 암 약물을 선별하는 시스템을 포함한다.

한편, 본 발명의 다양한 실시예 중 일 실시예를 설명하면, 본 발명은 (A) 약물반응에 영향을 미치는 변이들에 대한 양적형질위치(QTL)들의 위치모음을 산출하는 단계와; (B) 상기 양적형질위치(QTL)에 포함된 변이에 대한 기능하플로타입을 생성하는 단계와; (C) 상기 기능하플로타입을 기반으로 변이와 약물반응 상관관계 계산하는 단계; 그리고 (D) 상기 기능하플로타입을 기반으로 약물반응성을 예측하는 단계를 포함하여 수행될 수 있다.

이때, 상기 제(A)단계의 양적형질위치(QTL)들의 위치모음을 산출은, (A1) 복수의 세포주로부터 변이들과 유전자 RNA 발현의 상관관계를 도출하는 단계와; (A2) 약물들과 복수의 셀라인 유전체에 포함된 유전자 RNA발현 및 유전자 복제수변이(CNV)들과의 상관관계 도출하는 단계와; (A3) 상기 제(A1)단계 및 제(A2)단계에서 공통 적으로 상관관계에 영향을 미치는 유전자 RNA 발현 또는 유전자 복제수변이에 대한 유전자 발현 정보를 산출하는 단계; 그리고 (A4) 상기 유전자 발현정보에 관여된 단일 또는 다중 변이를 산출하여, 약물반응에 영향을 미치는 변이들에 대한 양적형질위치(QTL)를 산출하는 단계를 포함하여 수행되는 양적형질위치(QTL)들의 위치모음 생성 단계를 포함하여 수행될 수 있다.

그리고 상기 제(B)단계의 기능하플로타입의 생성은, 유전체통합DB로부터 양적형질위치(QTL)에 포함된 단일 또는 다중변이에 대한 하플로타입을 약물반응성과 함께 추출하여 생성될 수도 있다.

또한, 상기 기능하플로타입은, 유전자 RNA발현(Exp)과 약물반응성과의 상관관계 정보와; 유전자 다중변이(loci)와 약물반응성과의 상관관계 정보를 포함하여 구성될 수도 있다.

한편, 상기 기능하플로타입은, 유전자 복제수변이(CNV)와 약물반응성과의 상관관계 정보와; 유전자 다중변이(loci)와 약물반응성과의 상관관계 정보를 포함하여 구성될 수도 있다.

여기서 상기 유전자 다중변이(loci)는, 양적형질위치(QTL)기반으로 선별된 로커스(locus)들의 모음일 수도 있다.

그리고 상기 유전체통합DB는, 지노타입(Genotype)으로 구성된 셀라인(Cell Lines) 통합 DB일 수도 있다.

또한, 상기 약물 반응성은, ln Ic50 값으로 표현될 수도 있다.

그리고 상기 유전자 RNA발현은, 과발현(over-expression), 변화없음(normal) 및 저발현(under-exprfession)으로 구분될 수도 있다.

또한, 상기 복제수변이(CNV)는, 증폭(amplification), 변화없음(normal) 및 감소(deletion)로 구분될 수도 있다.

한편, 상기 제(C)단계의 상관관계 계산은, (C1) 유전자 다중변이(loci)와 연관된 유전자 RNA발현(Exp)를 판별하는 단계와; (C2) 상기 기능하플로타입으로부터 상기 유전자 RNA발현(Exp)에 대한 약물반응성을 산출하여 상기 유전자 다중변이(loci)에 대한 약물반응성을 판별하는 단계; 그리고 (C3) 상기 기능하플로타입에 포함된 유전자 다중변이(loci)와 약물반응성과의 상관관계 정보로부터 산출된 약물반응성과 상기 제(C2)단계에서 판별된 약물반응성을 비교하여 검증하는 단계를 포함하여 수행될 수도 있다.

그리고 상기 제(C1)단계의 연관은, 상기 유전자 다중변이(loci)가 포함된 세포주 및 상기 세포주에 포함된 유전자 RNA발현(Exp)정보를 판별함에 의해 수행될 수도 있다.

또한, 상기 제(D)단계의 약물반응성을 예측은, 유전자 RNA발현 차이에 대한 약물반응의 차이가 과발현보다 저발현이 큰 경우, 유전자 RNA의 저발현이 약물반응에 민감한 것으로 판단하고; 유전자 RNA발현 차이에 대한 약물반응의 차이가 과발현보다 저발현이 작은 경우, 유전자 RNA의 과발현이 약물반응에 민감한 것으로 판단할 수도 있다.

그리고 상기 제(D)단계의 약물반응성을 예측은, 과발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값이 저발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값보다 크면, 유전자 RNA의 과발현이 유전자 다중변이(loci)타입과 연관된 것으로 판별하고; 과발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값이 저발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값보다 작으면, 유전자 RNA의 저발현이 유전자 다중변이(loci)타입과 연관된 것으로 판별할 수도 있다.

한편, 상기 기능하플로타입은, 해시넘버 (hash number)로 표현될 수도 있다.

그리고 상기 기능하플로타입과 약물반응의 상관관계는, 해시넘버를 이용하여, 약물반응성정보와 조합상관관계 테스트(Pairwise Pearson Test)를 수행함에 의해 산출될 수도 있다.

한편, 본 발명은 전술한 바와 같은 방법으로 기능하플로타입을 생성하는 약물반응성, 유전자발현정보 및 복제수 변이를 이용한 기능하플로타이핑 시스템을 포함한다.

이때, 상기 기능하플로타입은, 약물에 대한 반응성 진단, 약물에 대한 환자군을 선별하는 동반진단을 위한 바이오마커 발굴, 약물표적발굴 또는 약물에 대한 가상임상에 사용될 수도 있다.

위에서 살핀 바와 같은 본 발명에 의한 가상임상을 위한 암약물반응성, 연계된 유전자발현정보 및 복제수 변이를 이용한 기능 하플로타이핑 시스템 및 방법에서는 다음과 같은 효과를 기대할 수 있다.

즉, 본 발명에서는 체내(in vivo), 체외(in vitro) 혹은 유전정보에 대한 알려진 약물의 반응성 결과들로부터, 약리 효과가 밝혀지지 않은 약물의 반응성 정도를 예측할 수 있는 효과가 있다.

또한, 본 발명은 유전체의 변이정보에 대한 약물을 구성하는 약리 관능기의 반응성 상관관계를 도출할 수 있으므로, 분석대상인 유전체의 변이 및 약물의 약리 관능기를 추출하면, 해당 유전체에 대한 약물의 반응성 정도를 신뢰성 있게 예측할 수 있는 효과가 있다.

그리고 본 발명은 유전체의 변이 특성정보에 대한 약물타입의 반응성 상관관계를 도출할 수 있으므로, 분석대상인 유전체의 변이에 대한 특성정보 및 약물타입정보를 알면, 해당 유전체에 대한 약물의 반응성 정도를 신뢰성 있게 예측할 수 있는 효과가 있다.

이를 통해 본 발명은, 미지의 고분자화합물(약물 개발 대상 물질)의 특정 유전체를 포함하는 세포주 혹은 인체에 대한 반응성을 임상시험 전에 예측할 수 있으므로, 신약 개발에 따른 시간 및 비용을 현저하게 줄일 수 있는 효과가 있으며, 이미 개발된 약물에 대하여도, 임상에서 밝혀진 유전체 이외의 다른 유전체에 대한 반응성 정도를 미리 예측할 수 있으므로 기존 약물에 대한 다른 용도의 발견 및 부작용 발견에 대한 연구 비용 및 시간을 현저히 줄여주는 효과가 있다.

도 1은 본 발명에 의한 약물반응예측을 위한 양적 형질 위치(QTL), 유전복제수변이 및 RNA발현예를 도시한 예시도.
도 2는 본 발명에 의한 유전적 바이오마커를 활용한 약물반응성 계산 스키마를 도시한 예시도.
도 3은 본 발명에 의한 유방암의 유전적 바이오마커와 약물반응성의 관계를 도시한 예시도.
도 4는 본 발명에 의한 NGS입력과 약물반응 및 RNA발현 네트워크를 도시한 예시도.
도 5는 본 발명에 의한 세포주 약물반응 값(IC50)과 기능하플로타입의 상관관계를 도시한 예시도.
도 6은 본 발명에 의한 양적형질 위치(QTL)와 약물반응 상관관계를 도시한 예시도.
도 7은 본 발명에 의한 변이, RNA발현, 유전자복제수변이 및 약물반응 네트워크를 도시한 예시도.
도 8은 본 발명에 의한 변이와 상관관계 세포주, 암, 약물반응, RNA발현 및 CNV증폭 예를 도시한 예시도.
도 9는 본 발명에 의한 기능하플로타입과 약물반응성 상관관계 계산 스키마를 도시한 예시도.
도 10은 본 발명에 의한 기능하플로타입와 약물반응성 네트워크를 도시한 예시도.
도 11은 본 발명에 의한 기능하플로타입과 유전자발현 및 유전자복제수변이 예를 도시한 예시도.
도 12는 본 발명에 의한 기능하플로타입 정의를 도시한 예시도.
도 13은 본 발명에 의한 FRH 방법과 유전자 발현과 약물 반응성 예측 예를 도시한 예시도.
도 14는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.0인 실시예를 도시한 예시도.
도 15는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.5인 실시예를 도시한 예시도.
도 16은 본 발명에 의한 기능하플로타입과 유전자발현 실시 예를 도시한 예시도.
도 17은 본 발명에 의한 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델 생성예를 도시한 예시도.
도 18은 본 발명에 의한 기능하플로타입과 약물반응성 연관관계 R^2를 도시한 예시도.
도 19는 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH의 실시예를 도시한 예시도.
도 20은 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH를 사용한 예측 모델의 일 실시예를 도시한 예시도.
도 21은 본 발명에 의한 FRH를 사용한 혈액암의 약물반응성 예측의 일 실시예를 도시한 예시도.
도 22는 본 발명에 의한 FRH를 사용한 활용가능 시스템의 일 예를 도시한 예시도.
도 23은 본 발명에 의한 FRH 바이오마커를 이용하여 암 및 약물 동반진단 칩을 제작하는 방법의 일 예를 도시한 예시도.
도 24는 본 발명에 의한 바이오마커 표현구조의 구성을 설명하는 예시도.

이하에서는 첨부된 도면을 참조하여 본 발명의 구체적인 실시예에 의한 가상임상을 위한 암약물반응성, 연계된 유전자발현정보 및 복제수 변이를 이용한 기능 하플로타이핑 시스템 및 방법을 살펴보기로 한다.

설명에 앞서 먼저, 본 발명의 효과, 특징 및 이를 달성하는 방법은 첨부되는 도면과 함께 상세하게 후술되어 있는 실시 예에서 명확해진다. 그러나 본 발명은 이하에서 개시되는 실시 예들에 한정되는 것이 아니라 서로 다른 다양한 형태로 구현될 수 있으며, 단지 본 실시 예들은 본 발명의 개시가 완전하도록 하고, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자에게 발명의 범주를 완전하게 알려주기 위해 제공되는 것이며, 본 발명은 청구항의 범주에 의해 정의될 뿐이다.

본 발명의 실시 예들을 설명함에 있어서 공지 기능 또는 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명을 생략할 것이며, 후술되는 용어들은 본 발명의 실시 예에서의 기능을 고려하여 정의된 용어들로서 이는 사용자, 운용자의 의도 또는 관례 등에 따라 달라질 수 있다. 그러므로 그 정의는 본 명세서 전반에 걸친 내용을 토대로 내려져야 할 것이다.

도 1은 본 발명에 의한 약물반응예측을 위한 양적 형질 위치(QTL), 유전복제수변이 및 RNA발현예를 도시한 예시도이고, 도 2는 본 발명에 의한 유전적 바이오마커를 활용한 약물반응성 계산 스키마를 도시한 예시도이며, 도 3은 본 발명에 의한 유방암의 유전적 바이오마커와 약물반응성의 관계를 도시한 예시도이고, 도 4는 본 발명에 의한 NGS입력과 약물반응 및 RNA발현 네트워크를 도시한 예시도이며, 도 5는 본 발명에 의한 세포주 약물반응 값(IC50)과 기능하플로타입의 상관관계를 도시한 예시도이고, 도 6은 본 발명에 의한 양적형질 위치(QTL)와 약물반응 상관관계를 도시한 예시도이며, 도 7은 본 발명에 의한 변이, RNA발현, 유전자복제수변이 및 약물반응 네트워크를 도시한 예시도이고, 도 8은 본 발명에 의한 변이와 상관관계 세포주, 암, 약물반응, RNA발현 및 CNV증폭 예를 도시한 예시도이며, 도 9는 본 발명에 의한 기능하플로타입과 약물반응성 상관관계 계산 스키마를 도시한 예시도이고, 도 10은 본 발명에 의한 기능하플로타입와 약물반응성 네트워크를 도시한 예시도이며, 도 11은 본 발명에 의한 기능하플로타입과 유전자발현 및 유전자복제수변이 예를 도시한 예시도이고, 도 12는 본 발명에 의한 기능하플로타입 정의를 도시한 예시도이며, 도 13은 본 발명에 의한 FRH 방법과 유전자 발현과 약물 반응성 예측 예를 도시한 예시도이고, 도 14는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.0인 실시예를 도시한 예시도이며, 도 15는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.5인 실시예를 도시한 예시도이고, 도 16은 본 발명에 의한 기능하플로타입과 유전자발현 실시 예를 도시한 예시도이며, 도 17은 본 발명에 의한 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델 생성예를 도시한 예시도이고, 도 18은 본 발명에 의한 기능하플로타입과 약물반응성 연관관계 R^2를 도시한 예시도이며, 도 19는 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH의 실시예를 도시한 예시도이고, 도 20은 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH를 사용한 예측 모델의 일 실시예를 도시한 예시도이며, 도 21은 본 발명에 의한 FRH를 사용한 혈액암의 약물반응성 예측의 일 실시예를 도시한 예시도이고, 도 22는 본 발명에 의한 FRH를 사용한 활용가능 시스템의 일 예를 도시한 예시도이며, 도 23은 본 발명에 의한 FRH 바이오마커를 이용하여 암 및 약물 동반진단 칩을 제작하는 방법의 일 예를 도시한 예시도이고, 도 24는 본 발명에 의한 바이오마커 표현구조의 구성을 설명하는 예시도이다.

본 발명은 기본적으로, (A) 암 환자에게서 임상적으로 추출하기 어려운 유전자 RNA 발현정보 및 복제수변이 정보를 양적형질 위치(QTL)를 선행 계산하고, (B) 비임상 세포주 DB(GDSC 및 CCLE)와 같은 공용 데이터를 이용하여 유전자 RNA 발현정보 및 복제수변이 정보와 약물반응성 상관관계 실험 정보를 확보한 후, 상기 제(A)단계 및 제(B)단계를 통합하여 양적형질 위치(QTL)와 암약물반응 상관성을 계산하여 예측모델을 생성한다.

그리고 암 환자에게서 획득될 수 있는 유전체 정보를 기반으로 기능정보를 포함한 하플로타입을 계산하여 암환자의 약물반응성정보를 예측한다.

도 1에는 약물반응예측을 위한 양적 형질 위치(QTL), 유전복제수변이 및 RNA발현 예가 도시되어 있다. 즉, ①의 eQTL 실험 예문에서는, 변이와 발현의 직접(cis) 및 간접(trans)방식에 의해 조절되는 것이 나타나있고, ②의 Drug-Gene Expression은 약물과 RNA 발현의 상관관계를 보여준다. 그리고 ③의 Drug Cell viabillity는 약물의 농도와 세포의 활성관계를 보여주고, ④의 Drug-CNV는 약물의 농도와 유전자 복제수 변이(CNV)와의 상관관계를 보여준다. 그리고 ⑤의 Expression-CNV는 유전자 발현과 복제수 변이(CNV)와 상관관계를 보여준다.

즉, 도 1은 약물의 농도와 RNA 발현 및 유전자복제수변이(CNV)가 서로 상관관계를 가지고 있다는 것을 보여주고, 또한, 많은 경우에 RNA발현 및 유전자복제수변이(CNV)는 그것의 원인이 되는 단일 및 다중 변이와의 상관관계가 있음을 보여준다.

도 2에는 유전적 바이오마커를 활용한 약물반응성 계산 스키마에 있어, 대부분의 알려진 활성 약물이 약물에 민감한 군과 약물에 저항성을 주는 군으로 나누어지고, 이때, 민감성 및 저항성은 유전적 바이오마커와 밀접하게 연결되어 있다.

여기서, 유전적 바이오마커는 생식 및 체세포 변이, 드라이버변이, 복제수변이, 기능 하플로타입 변이, 후성 변이인 methylation 및 유전자 발현 등으로 구성된다.

그리고 도 3에는 유방암의 유전적 바이오마커와 약물반응성의 관계의 일예가 도시되어 있다. 유전적바이오마커들의 메커니즘을 나타내는 A) 계략도에서 Her2 유전자가 과발현되어 있을 때, 세포표면 수용체를 표적으로 하는 약물인 tratuzumab와 세포 내부의 cytoplasm에서의 길항제를 표적으로 하는 lapatinib 및 두 개의 바이오마커 PI3CA와 PTEN의 위치가 나타나 있다. B) 그래프에는 tratuzumab 및 lapatinib의 경우 wild type과 PI3CA가 변이를 가진 경우와, PTEN까지 기능을 못하는 경우에 대하여 약물반응성이 계산된 결과가 나타나 있고, 약물 pathway 메카니즘에서 약물표적의 위치에 따라 바이오마커의 변이가 1개 및 2개에 대한 약물반응성이 달라짐이 도시되어 있다.

한편, 도 4에는 NGS 입력과 약물반응 및 RNA발현 네트워크의 일 예가 도시되어 있다.

NGS 입력과 약물반응 및 RNA발현 네트워크의 기본 구조는, A) NGS 입력데이터로부터 선행으로 계산된 양적형질 위치(QTL)기반 유전자 RNA 과발현/저발현 및 유전자 복제수 변이의 증폭/감소를 예측하고, B) 비임상(in vitro) 공용 약물 반응성 데이터와 유전자발현 데이터와 상관관계 정보를 이용하여, C) 임상(in vivo)에서 양적형질 위치(QTL)기반 약물반응을 예측한다.

본 발명은 A) 양적형질 위치(QTL) 정보를 확보하고, B) 유전자 RNA 발현정보와 약물반응성 실험데이터를 라이브러리(DB)화하고, C) 약물반응성을 예측하는 과정으로 설명될 수 있다. 이는 일반적으로 환자에 대하여 B) 단계의 약물반응정보 및 유전자발현 정보를 짧은 시간에 확보하기가 어럽거나 일부는 거의 불가하기 때문이다.

따라서, 도 1 내지 도 4는 환자로부터는 유전체정보 및 RNA발현정보 기반 양적형질 위치(QTL) 정보와 관련을 가진 단일 및 다중 변이정보를 확보하고, 공용 약물반응성 정보인 비임상(in vitro) 세포주 실험 정보와 연결을 만들고, 임상(in vivo)에서 환자에게 적용하는 방식이다.

도 5는 세포주 약물반응 값(IC50)과 기능하플로타입의 상관관계 예시도로, 도 5에는 최종적으로 세포주들과 약물반응성 정보 및 기능하플로타입의 상관관계를 Pearson 상관관계로 계산하는 예가 도시되어 있다. 도 5에서는 265개 약물을 18(Dn)개 약물 pathway로 분류하여 적용을 하고, 기능하플로타입은 12개 암종(Cancer N)에 대하여 각 세포주 유전체에서 양적형질 위치(QTL) 정보기반으로 이미 약물반응과 관련을 가지고 있는 변이들의 조합(다중변이)들을 해시 수(hash number)로 바꾸어서, Pearson 상관관계를 구하는 형태의 계략도를 보여준다.

그리고 도 6은 양적형질 위치(QTL)와 약물반응 상관관계 예시도도를 보여 주고 있다. ①은 eQTL, ②는 cQTL, ③은 dQTL, ④는 유전자 RNA 발현과 유전자복제수변이의 상관관계, ⑤는 약물농도와 유전자 RNA발현, ⑥은 약물농도와 유전자복제수변이와의 상관관계를 보여준다.

본 발명에서 ① eQTL 및 ② cQTL이 사용되고, ③ 내지 ⑥은 결과물로서 혹은 상관관계가 있는 상태를 보여준다.

도 7은 변이, RNA발현, 유전자복제수변이 및 약물반응의 네트워크 구조를 나타내는 예시도로, 도 6에 도시된 내용을 서로 간의 연관성 관점으로 네트워킹을 만든 계략도이고, 지노타입(단일 변이), 하플로타입(조합 및 다중변이) 및 약물반응과의 조건식들의 관계를 보여준다.

본 발명에서 기능하플로타입은 단일변이 및 다중변이를 모두를 통칭한다.

그리고 각 변이들은 모두 양적형질 위치(QTL)의 방법에 의하여, 유전자 RNA 발현과 유전자복제수변이의 상관관계가 p-value < 10^5 이하로 정하여 수집된다.

한편, 도 8에는 변이와 상관관계 세포주, 암, 약물반응, RNA 발현 및 CNV 증폭의 예가 도시되어 있다. 이때, 상호 연관된 변이와 세포주, 암, 약물반응, RNA 발현 및 CNV 증폭의 예는 최종적으로 선별된 양적형질 위치(QTL)기반 약물반응성-변이-RNA발현-CNV가 하나의 객체로서 묶여 있다.

또한, 변이(지노타입)은 염색체의 위치, 변이 타입, 아미노산변이, 바이오마커로서의 활용 유무정보 등과도 연결될 수 있다.

한편, 도 9에 도시된 기능하플로타입과 약물반응성 상관관계 계산 스키마에 의하면, 본 발명은 크게 제1단계 및 제2단계로 구성된다.

제1단계는 양적형질 위치(QTL)들의 위치 모음을 생성하는 단계이고, 제2단계는 기능하플로타입과 약물반응 상관관계 계산하는 단계이다.

구체적으로, 제1단계는 1) 변이(전체 4백만)와 유전자들(20,000)의 발현 상관관계 계산하는 단계와, 2) 약물(265개)과 셀라인 유전체(1,000개)의 유전자발현과(각 20,000 여개)의 상관관계 계산하는 단계와, 3) 1) 및 2)에서 다중 혹은 단일변이와 연관을 가진 유전자발현 패턴이 같은 것을 수집하는 단계 및 4) 유전체통합DB에서 하플로타입(단일 및 다중변이)을 약물반응성과 함께 추출하는 단계를 포함하여 수행된다.

그리고 제2단계는 5) 이와 같은 하플로타입을 기능과 연관관계 하플로타입인 기능하플로타입(FRH)으로 정의하고, FRH를 해시넘버 (hash number)로 표현하는 단계 및 6) 해시넘버와 약물반응성 조합 상관관계 테스트(Pairwise Pearson Test)를 계산하는 단계를 포함하여 수행되고, 이들 과정을 모든 암 종에서 반복 수행한다.

또한, 도 10에는 기능하플로타입과 약물반응성의 네트워크가 도시된 것으로, 도 9에 도시된 기능 하플로타이핑 방법을 구현하기 위한 시스템을 나타낸다.

즉, QTL방법에 의한 단일 혹은 다중변이와 유전자 RNA발현 및 약물 반응데이터의 관계 및 Genotype으로 구성된 Cell Lines(c1~c-N) 통합 DB에서 다중변이를 추출하여 기능하플로타입을 추출하는 과정이 도시되어 있다.

그리고 도 11의 기능하플로타입과 유전자 RNA 발현 및 유전자복제수변이 예시도에는, 기능적인 관점에서 도 9의 과정을 구체적으로 설명을 한다.

즉, A)는 약물반응성 정보와 유전자 RNA발현의 관계를 최종결과물인 다중면이(loci)와 Exp으로 표현되고, 약물반응성 정보와 유전자복제수변이(CNV)의 관계를 loci와 CNV로 표현됨을 나타내고 있다.

그리고 B)는 이에 대한 상세 스키마로, 약물의 경우 Ln Ic50의 경우 '-2'는 민감성을 나타내고, '0'은 중간 민감성을 나타내며, '2'는 약물내성을 나타낸다.

한편, 다중변이(loci)는 양적형질 위치(QTL)기반으로 선별된 locus들의 모음으로 설명되고, loci는 다양한 타입인 loci-1, loci-2, ... loci-N으로 표현이 되며, 각 loci 타입은 전체 집단에서의 빈도(frequency)를 가지게 된다.

그리고 각각의 빈도 군에서 평균 약물반응성 정보인 ln IC50값(X, Y, …Z)이 산출된다.

한편, 유전자 RNA발현의 경우는 3가지 다른 발현 패턴을 가지는데, 이는 과발현(over-expression), 변화없음(normal), 및 저발현(under-exprfession)형식으로 표현이 될 수 있고, loci 타입과 같은 방식으로 각 타입에서 빈도(frequency)가 그룹화가 될 수 있고, 각 그룹에서의 평균 Ln IC50값(X', Y', …Z')이 산출된다.

그리고 같은 방식으로 복제수변이인 CNV의 경우도 증폭(amplification), 변화없음(normal) 및 감소(deletion)로 구분되고, 각 빈도(frequency) 군(group)에서 평균 약물반응성 정보인 ln IC50값(X", Y", …Z")이 산출된다.

또한, loci, gene-exp, gene-CNV 모두 다 빈도값이 가중치형태로 0~1의 스케일로 표현될 수 있다.

따라서, B)는 loci와 Exp, loci와 CNV에 가중치가 곱해진 것으로 설명될 수 있다.

도 12는 기능 하플로타입 정의를 나타내는 것으로, 본 발명에서 상대 기능 하플로타입(relative-Haplotype)이라 함은, 기능하플로타입(FRH)과 eQTL에서 유의성을 주는 locus들의 조합(Loci)으로서 기능적으로 연관된 하플로타입 관계를 말한다.

여기서, 기능하플로타입은 게놈 어셈블버전인 Dec. 2013 (GRCh38/hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 참고(reference)서열을 기준으로 개별 세포주 및 개인이 다른 다형성정보(allele)를 가진 형태로 정의된다. 그리고 FRH(Exp | IC50)는 유전자 발현차이에 대한 약물반응 절대값 민감도 차이(Normal 대 Over 혹은 Under)를 나타내고, FRH(Loci | IC50)는 세포주 들에 대한 기능적으로 연관된 하플로타입에 대응된 약물반응 절대값 민감도 차이를 말한다.

따라서, 약물반응값과 유전자 RNA발현의 관계와, Loci의 특정 타입과 같은 패턴의 유전자 RNA발현을 연결을 지을 수 있고, 일 예로, 도 12에서, [2]의 loci-3과 [1]Exp-over와 연결되어 있음을 보여준다.

즉, loci-3은 RNA발현이 over가 되는 것과 QTL관계에 있고, RNA발현이 over가 되어 있을 때 약물반응성 값은 loci-3의 약물발현성 값과 같은 것으로 예측할 수 있다.

또한, [3]에 도시된 바와 같이, FRH(Exp | IC50)은 변화없음(normal)에서의 약물반응성값과 비교하여 절대값 약물반응성 차이가 큰 값(max)를 나타내고, FRH(Loci | IC50)는 다양한 하플로타입에서의 약물반응 변화없음(normal)에서의 약물반응성 값과 비교하여 절대값 약물반응성 차이가 가장 큰 값(max)를 나타낸다.

한편, 도 13에는 FRH 방법과 유전자 발현과 약물 반응성을 예측한 예를 통하여, 도 12에 정의된 하플로타입을 좀 더 구체적으로 설명을 할 수 있다.

즉, 도 13의 [1] 및 [2]은 유전자 발현차이에 대한 약물반응 절대값 민감도 max 차이(Normal 대 Over 혹은 Under)를 각각 나타내고, [3]은 세포주 들에 대한 기능적으로 연관된 하플로타입에 대응된 약물반응 절대값 민감도 max 차이를 나타내며, [4]는 발현 차이에 대한 약물반응의 차이가 저발현 보다 더 크면 s=1, 그리고, 그 반대면 s=0이라 정의하는 것을 나타낸다. 따라서, s=1은 과발현이 약물반응에 민감하다는 것이고, S=0은 저발현이 약물반응이 민감하다는 것을 의미한다.

그리고 [5]는 [1] 및 [2]에서 정의한 ds^over가 ds^under보다 크면 m=1, 그렇지 않으면 m=0이라 정의하는 것을 나타내고, m=1이면 특정 loci타입이 유전자의 경우 과발현을 의미하고, m=0일 경우 유전자의 저발현이 특정 loci타입와 연관됨을 의미한다.

한편, 도 14는 FRH의 한 예시로 평균 IC50 값의 차이가 '1.0'인 예의 데이터를 표로 보여준다. 여기서, 평균 약물반응성(LN IC50)이 1인 경우 높은 양성 상관관계를 보인다 (pval <2.812*10^-7).

그리고, 도 15는 FRH의 한 예시로 평균 IC50 값의 차이가 '1.5'인 예의 데이터를 표로 보여준다. 여기서, 평균 약물반응성(LN IC50)이 1.5인 경우 훨씬 높은 음성 상관관계를 보인다 (pval <7.191*10^-7).

또한, 도 16에는 기능적으로 연관된 하플로타입과 유전자발현 실시예가 도시되어 있다.

이 실시예의 경우, 혈액암(blood)의 경우, FRH이 4개의 타입을 포함하는 것을 보여준다. 이때, 변이(locus위치)는 1: Ref Homo, 2: Hetero, 3: Alt Homo의 3개의 다른 지노타입(genotype)으로 설명이 된다.

그리고 첫 번째 컬럼의 혈액암(blood)에서 2개의 locus의 조합으로 표현하면, 각 타입의 빈도(frequency)는 두 번째 컬럼, '12'는 1명, '21'은 1명, '11'은 2명 그리고 '22'는 153명으로 다수를 보여준다.

또한, Afatinib 약물에 대하여 '11'의 경우 유전자발현은 과발현(2.404)이고, 약물반응성(LN IC50)은 -1.21, 즉 Afatinib 약물에 대하여 민감성이 있다는 것을 보여준다. 이 예시의 내용을 요약하면, 2개의 locus를 조합으로 하는 FRH는 '11' 타입에서 EGFR 유전자가 과발현되고, 그것이 원인이 되어서 약물반응성이 민감하다. 따라서, FRH는 '11' 타입을 가지는 세포주 및 환자는 Afatinib약물에 민감하다고 예측할 수 있다.

그리고 도 17에는 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델 생성 방법이 도시되어 있다. 이에 도시된 바와 같이, 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델은 1) 기능연관 하플로타입(FRH)과 특정암의 특정약물 패스웨이(Drug Pathway)와 관련된 각 약물과의 상관관계를 계산하고, 2) FRH 및 약물반응성 상관관계로 구성되는 메트릭스 X축 및 Y축의 상관관계 정보를 클러스터링을 하고, 3) 예측모델에서 유의성(p-value)이 높은 것을 수집하여, 이들의 상호작용 기능을 모델에 적용하고, 4) NGS 데이터를 입력으로 하여 약물반응성과 연관을 가진 FRH를 계산하여 약물반응성을 예측한다.

한편, 도 18에 도시된 기능하플로타입과 약물반응성 연관관계 R^2는 도 17의 예측모델 생성 방법의 2)상관관계 정보의 클러스터링 과정의 일 예를 설명한다. 여기서, 암 타입은 혈액암이고, Y: EGFR pathway 9 drugs, X: FRH 하플로타입 그리고 각 pixel은 약물반응값과 FRH의 Pearson 상관관계를 나타내고, 여기서 *는 유의성(pval<0.05)을 나타내고, **는 유의성(pval<0.01)을 나타낸다.

또한, 파랑색은 양성으로의 상관관계를 보여주고, 주황색은 음성으로의 상관관계을 보여준다.

그리고 도 19는 도 18의 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH의 예를 보여준다. 특히, 4개 FRH(LAMC2_2, JPH1_2, PRKCB_3, CML_1)와 약물반응성 상관관계를 결과를 나타내고 있다.

한편, 도 20은 도 18의 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH를 사용한 예측 모델의 일 예로, 도 17의 예측모델 생성 방법의 3) 상호작용 기능을 모델에 적용한 일 예를 설명한다. 특히, p-val<0.01이하인 FRH 21개는 상호작용 텀(term)으로 넣고, 선형 회귀(Leaner Regression)모델을 적용한 예시이다. 이 경우는 Pearson 상관관계가 0.89이다.

또한, 도 21은 혈액암 환자 1명 유전체의 기능하플로타입을 가지고 다양한 약물(AP-24534, PAC-1, Obatoclax Mesylate, Bleomycin 등)에 대한 예측된 IC50(real)값들을 보여준다. 이 결과 어떤 약물은 높은 민감도가 예측된 반면, 떤 약물은 높은 저항성이 예측된 것으로 나타난다. 그리고 실제값(IC50(real))의 민감도와 기능하플로타입 군의 평균 IC50(ave)값 사이에 일치성이 있음을 보여준다.

한편, 도 22에 도시된 바와 같이, 본 발명에 의한 차세대시퀀싱데이터 기반의 개인별 기능하플로타입들이 수집되면 다양한 영역에서 활용이 가능하다. 즉, 가상임상시험 및 실제임상시험, 신약표적발굴, 질병 약물 민감도 진단, 및 동반진단 바이오마커 발굴 시스템 등에 활용가능하다.

본 발명에서는 전술한 바와 같은 기능하플로타입을 통하여, 약물 반응성을 진단하는데 유의성있는 바이오 마커들을 발굴하였다.

발굴된 바이오 마커는 변이를 포함하는 DNA 염기로 크게 암의 종류(CancerClass) 별로 해당 암에 대한 약물의 반응성에 영향을 미치는 바이오 마커들과, 약물의 작용 경로(pathway) 및 표정 대상에 따라 구분되는 약물타입(DrugClass)에 별로 약물의 반응성에 영향을 미치는 바이오 마커들로 구분된다.

이하에서는 이와 같은 바이오 마커들을 종류별로 구분하여 정리하기로 한다.

먼저, 암타입(CancerClass)에 대한 구분 종류가 [표 1]에 정리되어 있다.

암타입(CancerClass)에 속하는 TCGA(the cancer genome atlas)의 정의

구분	CancerClass	TCGA	CANCER_NAME
1	혈액암(blood)	ALL LAML LCML	Acute lymphoblastic leukemia, Acute Myeloid Leukemia, Chronic Myelogenous Leukemia
2	여성암(breast, ovary)	BRCA BLCA UCEC OV CESC	Bladder Urothelial Carcinoma, Breast invasive carcinoma, Ovarian serous cystadenocarcinoma, Cervical squamous cell carcinoma and endocervical adenocarcinoma, Uterine Corpus Endometrial Carcinoma
3	뇌종양(brain)	LGG NB GBM	Glioblastoma multiforme, Brain Lower Grade Glioma, Neuroblastoma (nb)
4	두경부암(head&neck)	HNSC THCA	Head and Neck squamous cell carcinoma, Thyroid carcinoma
5	폐암(lung)	LUAD LUSC NSCLC	Lung adenocarcinoma, Lung squamous cell carcinoma
6	육종암(bone)	SARC	Sarcoma

위 [표 1]에 기재된 Cancer Class는 암발생부위 및 원인별 구분으로, 혈액암(blood), 여성암(breast, ovary), 뇌종양(brain), 두경부암(head&neck), 폐암(lung), 육종암(bone)으로 구분된다.

그리고 TCGA는 'The cancer genome atlas'에서 분류한 세부 암 유형을 나타내고, 각 항목에 대한 정보가 [표 1]에 기재되어 있다.

전술한 바와 같이, 본 발명에서는 기능하플로타입을 이용한 GBLscan을 통하여, 각 암 종류별로, 약물에 대한 반응성에 영향을 미치는 바이오마커를 산출하였다.

구체적으로, 암타입(Cancer Class)의 구분 별로, 혈액암(blood)의 바이오 마커 376개(표 2참조), 여성암(breast, ovary) 바이오 마커 95개(표 4참조), 뇌종양(brain)의 바이오 마커 1194개(표 6참조), 두경부암(head&neck)의 바이오 마커 77개(표 8참조), 폐암(lung)의 바이오 마커 477개(표 10참조), 육종암(bone)의 바이오 마커 397개(표 12참조)이다.

아래 [표 2] 내지 [표 12]에는 암 종류별로 본 발명에 의해 발굴된 바이오 마커가 표시되어 있다. 여기서 바이오 마커는 단일변이 및 다중변이의 조합일 수 있고, 변이의 형태 역시 단일염기다형성변이(SNV), 인델(Indel), 유전자 복제수 변이(CNV), 염색체 전위(chromosomal rearrangement) 등 다양한 형태의 변이일 수 있다.

한편, [표 2] 내지 [표 23] 및 [표 15] 내지 [표 42]에 표시되는 Gene_EXP는 도 24에 도시된 바와 같이, 해당 바이오마커의 mRNA 발현유전자의 명칭을 나타낸다. 그리고 상기 바이오 마커는 『표식1_표식2_표식3_표식4』의 형태로 표현되는데, 표식1은 바이오 마커가 포함된 염색체번호를 나타내는 것으로 1 내지 22 또는 X, Y 중 어느 하나의 값을 갖는다. 그리고 표식2는 해당 염색체 상에서 변이가 발생된 염기서열의 시작위치를 나타내는 것이며, 표식3은 변이 전 정상 염기를 나타내는 것으로 참조게놈(GRCh/hg38 기준)상의 해당 위치의 염기를 말한다. 한편, 표식4는 변이된 염기를 나타내는 것이다.

즉, [표 2] 내지 [표 23] 및 [표 15] 내지 [표 42]에 표시된 『표식1_표식2_표식3_표식4』의 형태로 표현된 바이오 마커는, 표식1염색체에 있어, 표식2 번째 부터의 표식3 염기가 표식4로 변이된 염기서열을 말한다.

따라서, 이때, 바이오 마커는 구체적으로, 표식1염색체에 있어, 표식2 번째 위치에서부터의 표식3의 염기 길이까지의 자리가 표식4의 염기로 구성되는 염기서열을 말한다.

예를 들어, [표 2]의 서열1의 바이오마커가 『14_30910985_T_G』로 표현되었는데, 이는 14번 염색체의 30910985번째 염기가 G인 염기서열이 바이오 마커임을 의미하고, [표 2]의 서열5의 바이오마커가 『13_113524119_TGTCA_T, 13_113510211_T_C, 13_113495576_T_C, 13_113503637_G_T, 13_113539563_C_T』로 표현되었는데, 이는 13번 염색체의 113524119번째 염기부터 113524123까지의 염기가 T이고(4자리의 염기는 '결실'됨을 의미한다), 13번 염색체의 113510211번째 염기가 C이며, 13번 염색체의 113495576번째 염기가 C이고, 13번 염색체의 113503637번째 염기가 T이며, 13번 염색체 113539563번째 염색체가 T인 염기서열이 바이오마커임을 의미한다.

도 24에 도시된 예를 살피면, [표 23]의 서열 29에 기재된 바이오 마커는, 'SLC6A12'염색체에서, 2번 염색체의 190673067번째 염기가 GT이고, 9번째 염색체의 114323991번째 염기가 G인 것을 의미한다. 이때, 2번 염색체의 190673067번째 염기는 G가 GT로 치환된 것임을 말한다.

한편, 1 내지 22번 염색체의 전체 염기서열은 전술한 바와 같이, 게놈 어셈블버전인 Dec. 2013 (GRCh38/hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 참고(reference)서열을 기준으로 한다.

blood(혈액암) 약물에 대한 반응성 바이오 마커

Cancer_Class	Gene_exp	바이오 마커 (발현조절 FRH 변이세트)
##blood	Gene_EXP:MARCH4	14_30910985_T_G
##blood	Gene_EXP:ACBD3	9_33799000_T_C
##blood	Gene_EXP:ACCS	11_44107740_C_A,7_135196179_C_T,9_61066407_C_T
##blood	Gene_EXP:ACSS2	8_143538013_T_C
##blood	Gene_EXP:ADA	13_113524119_TGTCA_T,13_113510211_T_C,13_113495576_T_C,13_113503637_G_T,13_113539563_C_T
##blood	Gene_EXP:ADAT2	5_141490949_A_G,17_41827392_A_C
##blood	Gene_EXP:ADCY9	6_42632921_A_T
##blood	Gene_EXP:AEBP1	6_72148713_GTT_G,13_24781827_GTT_GT,13_37746457_TAA_TA,20_34750522_TA_T,17_64858885_TA_T
##blood	Gene_EXP:AEBP1	6_72148713_GTT_G,6_146672170_GA_G,2_53919250_GA_G,13_24781827_GTT_GT,13_37746457_TAA_TA
##blood	Gene_EXP:AGPAT2	21_25714604_C_A
##blood	Gene_EXP:AGTRAP	2_178769706_G_T
##blood	Gene_EXP:AMFR	11_63488969_C_G
##blood	Gene_EXP:ANGPTL2	2_55222182_T_C
##blood	Gene_EXP:ANKRD22	7_38349808_A_G
##blood	Gene_EXP:ANPEP	2_182063828_G_C,3_75338856_G_A
##blood	Gene_EXP:ANXA2	4_36214492_A_T
##blood	Gene_EXP:AP2S1	10_68572309_C_T
##blood	Gene_EXP:AP4B1	2_127620227_T_G,2_219228043_A_C,3_49714047_T_G,5_180948948_T_G
##blood	Gene_EXP:APEH	15_70699666_A_G
##blood	Gene_EXP:APOC1	5_54519891_G_C
##blood	Gene_EXP:ARHGAP22	5_41008678_A_G,5_41009140_C_T,11_130470775_T_C
##blood	Gene_EXP:ARID1A	7_21862122_CT_C,11_63382198_CA_C
##blood	Gene_EXP:ARL3	2_182063828_G_C
##blood	Gene_EXP:ARPC1A	9_39118208_G_T,9_41938349_G_T,9_61081995_G_T
##blood	Gene_EXP:ARRB1	16_46710765_T_A
##blood	Gene_EXP:AS3MT	7_20786651_GA_G,1_225419673_GA_G,5_95507014_TA_T,9_120989554_CT_C,2_11192112_CT_C
##blood	Gene_EXP:ASCC1	2_186602115_A_C,10_97445797_T_G
##blood	Gene_EXP:ASH2L	9_33796659_C_T,9_33796705_C_G,9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
##blood	Gene_EXP:ASPH	19_39902109_T_G
##blood	Gene_EXP:ASXL1	7_5217942_G_A,11_89192074_G_C
##blood	Gene_EXP:ATP11A	2_85880864_T_C,3_132388903_G_A,9_128288585_G_C
##blood	Gene_EXP:ATP2A3	1_24074187_A_G,2_68818005_T_G
##blood	Gene_EXP:ATP6V0A1	11_63382198_CA_C
##blood	Gene_EXP:ATP7B	2_182063828_G_C,5_176336593_G_A,5_176347862_G_T
##blood	Gene_EXP:AZI1	4_85635_C_T,4_85671_G_A,4_86908_C_T
##blood	Gene_EXP:AZU1	2_135023465_C_T,2_135133038_G_C,11_129905704_C_T
##blood	Gene_EXP:B3GNT8	3_74301846_T_C,17_7771466_C_T,17_7801487_C_G
##blood	Gene_EXP:BARD1	9_133405414_T_G
##blood	Gene_EXP:BAZ2A	6_83940645_G_T
##blood	Gene_EXP:BCL11B	11_63382198_CA_C,6_152444591_GA_G,10_67956845_TA_T,3_196805277_CT_C,7_28494775_GT_G
##blood	Gene_EXP:BET1	1_1638657_A_G
##blood	Gene_EXP:BLCAP	4_48609132_A_G
##blood	Gene_EXP:BLM	9_33795626_A_C
##blood	Gene_EXP:BST1	3_75338856_G_A
##blood	Gene_EXP:C10orf11	1_13344015_T_C
##blood	Gene_EXP:C10orf25	17_39270861_TA_T
##blood	Gene_EXP:C11orf74	2_216109160_C_A,2_237751320_TAA_T,13_49377006_T_C,16_21520152_G_A,16_21533198_T_C
##blood	Gene_EXP:C12orf49	21_29056427_GTAC_G
##blood	Gene_EXP:C15orf26	17_999610_T_C
##blood	Gene_EXP:C17orf85	19_54909178_GA_G,1_52789915_CT_C,2_15396385_GA_G,6_7595008_AT_A,9_100450496_GT_G
##blood	Gene_EXP:CA2	1_156378043_T_A
##blood	Gene_EXP:CABLES2	17_74794950_A_G
##blood	Gene_EXP:CACNA2D4	2_42288248_A_G
##blood	Gene_EXP:CAMK2D	2_100964113_G_A,2_100977729_C_T,11_45181661_C_T
##blood	Gene_EXP:CARHSP1	13_24781827_GTT_GT,14_68477626_CT_C
##blood	Gene_EXP:CBFB	3_112112876_TA_T,15_74183919_A_G
##blood	Gene_EXP:CBX2	2_161993434_TA_T,12_109568919_GT_G
##blood	Gene_EXP:CCDC136	9_131430074_C_T,19_11301321_TA_T
##blood	Gene_EXP:CCND3	7_151221500_CT_C,14_68477626_CT_C
##blood	Gene_EXP:CD151	11_828784_A_G,11_840477_A_G,11_840319_C_T,11_838110_C_T,11_837582_G_A
##blood	Gene_EXP:CD44	8_132137720_G_A
##blood	Gene_EXP:CD72	2_138288359_C_T
##blood	Gene_EXP:CDCA7	20_46358679_C_G
##blood	Gene_EXP:CDK6	9_33796705_C_G,9_33797971_T_A,9_33797993_G_A,9_33797994_C_T,9_33798019_A_G
##blood	Gene_EXP:CDKN2B	5_113434330_T_G,5_113515266_G_A
##blood	Gene_EXP:CDT1	1_109668049_G_T,1_109669334_C_T,6_111008018_CT_C
##blood	Gene_EXP:CEP104	20_14326307_G_T
##blood	Gene_EXP:CEP57L1	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T,9_33798019_A_G
##blood	Gene_EXP:CEP85	1_109669334_C_T
##blood	Gene_EXP:CFL2	13_42888471_G_A,16_20317363_T_C
##blood	Gene_EXP:CFLAR	5_60605865_GA_G,7_28494789_G_T,9_130489245_A_T
##blood	Gene_EXP:CHID1	1_53250744_G_A,1_85071819_T_A,15_78922969_A_C,15_78939184_A_AG
##blood	Gene_EXP:CITED4	3_75338856_G_A
##blood	Gene_EXP:CLEC11A	5_179863845_T_G,16_46710765_T_A
##blood	Gene_EXP:CLIP1	7_1092820_C_T,7_1155657_T_TC,11_24976472_CTGTT_C
##blood	Gene_EXP:CMBL	11_117203393_G_A
##blood	Gene_EXP:CNTROB	13_97982483_AT_A,2_61498915_TA_T,3_37337179_CT_C,10_70860377_CT_C,5_64507681_TA_T
##blood	Gene_EXP:COMT	8_143538172_T_C,8_143538914_T_G
##blood	Gene_EXP:COPS8	11_69072603_C_T,11_124023539_A_G,11_124023038_C_T,16_57082546_T_C,16_57081660_C_T
##blood	Gene_EXP:CRADD	8_123427934_A_G,8_123429947_A_G,8_123436496_A_G,8_123436564_T_A,8_123437226_C_T
##blood	Gene_EXP:CRB3	15_98922244_C_T
##blood	Gene_EXP:CRY1	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T,9_33798019_A_G,19_1057777_GA_G
##blood	Gene_EXP:CSF3R	5_179863845_T_G,7_93426338_G_A,9_137986862_A_C,16_57081660_C_T,16_57082546_T_C
##blood	Gene_EXP:CTSL1	1_16580833_G_T
##blood	Gene_EXP:CXCL10	1_15726998_G_A,1_15729869_G_A
##blood	Gene_EXP:DAD1	12_54182016_C_A
##blood	Gene_EXP:DCTN4	X_3271895_G_A
##blood	Gene_EXP:DDX60L	6_143772215_C_T
##blood	Gene_EXP:DENND4A	7_151221500_CT_C,19_1057777_GA_G,19_51416180_GA_G
##blood	Gene_EXP:DGAT1	3_38905381_A_T,3_38910262_T_C,11_18484005_G_A
##blood	Gene_EXP:DGKZ	2_232380380_A_G,2_232380431_T_C
##blood	Gene_EXP:DISC1	11_129905704_C_T,14_105588411_G_A
##blood	Gene_EXP:DLC1	2_182063828_G_C,20_56366031_C_T
##blood	Gene_EXP:DOCK5	5_32053643_T_C
##blood	Gene_EXP:DOK2	2_23637298_G_A,2_23642306_G_A
##blood	Gene_EXP:DPCD	15_42211755_GA_G
##blood	Gene_EXP:DSTYK	3_53179641_T_C
##blood	Gene_EXP:DTD1	2_15396385_GA_G,5_77411610_TA_T,10_113620724_G_A,11_63382198_CA_C
##blood	Gene_EXP:DYSF	1_25390874_C_G,20_14326307_G_T
##blood	Gene_EXP:EFEMP2	6_111008018_CTT_C,6_163478762_CT_C
##blood	Gene_EXP:EGFR	1_16027940_A_T,1_16048568_C_G
##blood	Gene_EXP:ELANE	19_52435206_A_G
##blood	Gene_EXP:ELOVL5	13_37746457_TAA_TA
##blood	Gene_EXP:EMILIN2	5_179863845_T_G
##blood	Gene_EXP:EMP1	1_16580833_G_T
##blood	Gene_EXP:ENG	3_186558604_C_T,22_29806785_G_C
##blood	Gene_EXP:EPAS1	6_26390925_C_G
##blood	Gene_EXP:EPB41	11_1758992_A_C
##blood	Gene_EXP:ERMAP	10_111079134_C_A,4_25662622_G_A,2_160137837_C_T,2_182063828_G_C,2_160138253_A_G
##blood	Gene_EXP:EWSR1	14_68477626_CT_C,17_39270861_TA_T
##blood	Gene_EXP:FAM102A	20_10639738_A_G
##blood	Gene_EXP:FAM111B	19_49044175_A_G
##blood	Gene_EXP:FAM117A	7_114663436_A_AT,16_89586624_G_A
##blood	Gene_EXP:FAM63A	15_22573256_T_G
##blood	Gene_EXP:FAM83H	2_219489820_G_A,6_56701823_T_C
##blood	Gene_EXP:FANCD2	5_161895646_GT_G
##blood	Gene_EXP:FANCI	1_109669334_C_T,6_111008018_CT_C
##blood	Gene_EXP:FBXO16	5_850655_C_T,10_97581428_A_G,22_30119060_T_C,17_60990260_A_G,14_61457374_G_T
##blood	Gene_EXP:FBXO33	8_143538013_T_C
##blood	Gene_EXP:FCGR2A	10_18500795_T_G
##blood	Gene_EXP:FEM1C	1_15443607_G_A
##blood	Gene_EXP:FHL3	11_65543121_A_C
##blood	Gene_EXP:FKBP3	3_10301192_C_T,15_22715140_G_C
##blood	Gene_EXP:FLRT3	17_8012602_G_A
##blood	Gene_EXP:FLT3	2_110841381_C_T
##blood	Gene_EXP:FOXK2	10_119676966_A_G
##blood	Gene_EXP:FRAT2	1_215813880_T_C,1_215838019_T_C
##blood	Gene_EXP:G0S2	5_35904512_G_T
##blood	Gene_EXP:GAB2	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
##blood	Gene_EXP:GAB3	1_182884882_G_A
##blood	Gene_EXP:GALNT7	19_14388545_T_A
##blood	Gene_EXP:GATA2	2_182063828_G_C
##blood	Gene_EXP:GBP1	12_10373045_A_G
##blood	Gene_EXP:GLT25D1	5_135888024_G_T
##blood	Gene_EXP:GLTPD1	2_68502860_A_G,8_7740651_A_C,10_43845335_G_GC
##blood	Gene_EXP:GLUL	16_46710765_T_A
##blood	Gene_EXP:GMPR	2_182063828_G_C
##blood	Gene_EXP:GNA15	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T,9_33798019_A_G
##blood	Gene_EXP:GNAQ	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
##blood	Gene_EXP:GPR18	2_1542589_G_T
##blood	Gene_EXP:GRB10	7_51028450_A_G,12_56425138_C_T
##blood	Gene_EXP:GSN	11_129905704_C_T
##blood	Gene_EXP:GSR	22_19180296_A_C
##blood	Gene_EXP:HADHB	10_43100403_G_T
##blood	Gene_EXP:HBQ1	22_16433541_AC_A
##blood	Gene_EXP:HEBP1	2_182063828_G_C
##blood	Gene_EXP:HIBADH	18_35478354_GA_G
##blood	Gene_EXP:HNRNPA0	7_20786651_GA_G,11_33353067_AT_A,20_34750522_TA_T,6_152444591_GA_G,15_42211755_GA_G
##blood	Gene_EXP:HNRNPA0	7_20786651_GA_G,20_34750522_TA_T,15_42211755_GA_G,1_155914364_GA_G,11_33353067_AT_A
##blood	Gene_EXP:HNRNPUL1	10_27250013_T_C
##blood	Gene_EXP:HRH1	7_56078329_T_G,11_1758992_A_C
##blood	Gene_EXP:HTRA3	2_113641902_C_T,22_50769003_G_A
##blood	Gene_EXP:IFI30	14_77435415_G_GA
##blood	Gene_EXP:IGF2BP2	1_39522547_C_T
##blood	Gene_EXP:IMP4	10_133626801_G_T
##blood	Gene_EXP:INTU	2_197497294_T_C,X_152638267_A_G
##blood	Gene_EXP:ISG20	5_179863845_T_G
##blood	Gene_EXP:ITGA6	9_111758806_C_T,12_6952191_A_C
##blood	Gene_EXP:JAKMIP2	21_10605542_G_A
##blood	Gene_EXP:JPH1	5_128345465_A_C,16_81858185_C_G
##blood	Gene_EXP:JSRP1	15_22573256_T_G
##blood	Gene_EXP:KAT7	16_16036657_C_A
##blood	Gene_EXP:KATNB1	2_200412288_CT_C,19_9251064_CT_C,1_84490478_CT_C,4_8452742_GA_G,20_38562748_GT_G
##blood	Gene_EXP:KCNJ11	7_5943381_A_G,7_6781419_T_C,20_63940064_AGG_A
##blood	Gene_EXP:KCTD7	11_63646490_AAAAT_A,11_63719914_T_C,12_128669441_G_A
##blood	Gene_EXP:KDELR1	17_62447686_C_T,19_57475779_A_C,X_49304797_C_G
##blood	Gene_EXP:KDM1A	1_53923844_G_GT,1_53966346_G_A
##blood	Gene_EXP:KDM3B	6_43052450_G_A,6_43054205_C_T,6_43055633_T_C,11_117776746_C_G
##blood	Gene_EXP:KHDRBS1	19_11431113_CT_C
##blood	Gene_EXP:KIAA1377	19_2896950_T_C
##blood	Gene_EXP:KIF15	15_100152748_G_A
##blood	Gene_EXP:KIF3B	11_1017789_A_C
##blood	Gene_EXP:KLHL25	3_129433338_GT_G,6_43525297_GT_G,13_97982483_AT_A,6_70861991_TA_T,16_30280420_GA_G
##blood	Gene_EXP:KRT10	2_97196659_G_A,7_92671549_C_T
##blood	Gene_EXP:LAPTM4B	20_56366031_C_T
##blood	Gene_EXP:LCK	1_220110770_GT_G,7_73465568_GA_G,2_161993434_TA_T,6_46668819_GT_G,5_64507681_TA_T
##blood	Gene_EXP:LCK	7_73465568_GA_G,1_220110770_GT_G,2_161993434_TA_T,6_46668819_GT_G,5_64507681_TA_T
##blood	Gene_EXP:LEF1	6_136108863_GA_G,11_63382198_CA_C,9_100450496_GT_G,1_151694350_CT_C,13_37746457_TAA_TA
##blood	Gene_EXP:LEPRE1	1_205849911_C_T,1_205849976_G_A,4_68337362_T_C,4_182680440_G_C,4_182680513_G_A
##blood	Gene_EXP:LEPROTL1	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T,9_33798019_A_G
##blood	Gene_EXP:LGALS1	1_176043330_GA_G,2_113598783_G_A,20_13110086_AT_A
##blood	Gene_EXP:LIMS2	6_72148713_GTT_G,11_63382198_CA_C,3_196805277_CT_C,13_24781827_GTT_GT,13_37746457_TAA_TA
##blood	Gene_EXP:LMNA	12_120579461_C_T
##blood	Gene_EXP:LPAR6	12_131908770_A_C,X_136033510_GA_G
##blood	Gene_EXP:LPL	15_30372250_C_T
##blood	Gene_EXP:LRG1	13_28073352_GA_G
##blood	Gene_EXP:LRP3	1_165249397_C_G,9_77415913_G_T,3_75338856_G_A,6_159214911_T_G,7_81974555_G_GAA
##blood	Gene_EXP:LRP3	9_77415913_G_T,1_165249397_C_G,3_75338856_G_A,6_159214911_T_G,7_81974555_G_GAA
##blood	Gene_EXP:LRPAP1	7_36335190_G_A,22_39052745_T_C
##blood	Gene_EXP:MANBAL	1_24074187_A_G
##blood	Gene_EXP:MBLAC1	3_179365291_C_T
##blood	Gene_EXP:MED30	2_214997659_G_A
##blood	Gene_EXP:MEIG1	17_2334690_C_A
##blood	Gene_EXP:MICALL2	2_182063828_G_C
##blood	Gene_EXP:MIS18A	1_109669334_C_T
##blood	Gene_EXP:MLF1IP	10_69097096_G_A
##blood	Gene_EXP:MMP14	1_16580833_G_T
##blood	Gene_EXP:MPP1	7_114663562_CT_C,9_33796659_C_T,9_33798019_A_G
##blood	Gene_EXP:MRAS	11_1017789_A_C
##blood	Gene_EXP:MS4A3	19_49135699_C_G
##blood	Gene_EXP:MSI2	22_43972861_C_T
##blood	Gene_EXP:MSL2	5_64507681_TA_T,7_73465568_GA_G,8_73582883_GA_G,13_37746457_TAA_TA,13_37746457_TA_T
##blood	Gene_EXP:MTPAP	3_49714047_T_G
##blood	Gene_EXP:MUL1	19_6454640_T_C
##blood	Gene_EXP:MYL6B	11_284257_G_A
##blood	Gene_EXP:MYO1F	10_18500795_T_G
##blood	Gene_EXP:MYO5A	16_84661520_G_A
##blood	Gene_EXP:N4BP2	5_146267624_CT_C,9_120989554_CT_C,13_37746457_TAA_TA,16_84087473_CAA_C,19_11301321_TA_T
##blood	Gene_EXP:NAGS	5_176093676_A_T
##blood	Gene_EXP:NASP	1_109669334_C_T
##blood	Gene_EXP:NCOA3	3_54386725_A_G
##blood	Gene_EXP:NFAM1	9_15848985_C_T
##blood	Gene_EXP:NFE2	2_182063828_G_C
##blood	Gene_EXP:NFKBIA	10_43616797_G_A
##blood	Gene_EXP:NFYB	20_46358679_C_G
##blood	Gene_EXP:NINL	11_33353067_AT_A,13_24781827_GTT_GT,13_37746457_TAA_TA,13_37746457_TA_T
##blood	Gene_EXP:NME7	1_19700911_G_A
##blood	Gene_EXP:NNT	10_73696978_G_A
##blood	Gene_EXP:NOL4	1_26270944_G_A
##blood	Gene_EXP:NRM	11_4082830_A_C
##blood	Gene_EXP:NRN1	6_136108863_GA_G,12_66128874_G_A,20_24959128_C_T
##blood	Gene_EXP:NSMAF	1_117088769_T_C
##blood	Gene_EXP:NUDT2	2_25154307_T_C,14_94592125_A_C
##blood	Gene_EXP:NUDT3	11_119054629_G_A
##blood	Gene_EXP:NUP43	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
##blood	Gene_EXP:ORC1	1_109669334_C_T
##blood	Gene_EXP:ORMDL3	2_178769706_G_T,19_49044101_A_G
##blood	Gene_EXP:OSBPL11	10_122336520_T_C,10_122336546_A_C,17_4896602_C_T
##blood	Gene_EXP:OSBPL5	2_232380431_T_C
##blood	Gene_EXP:OSCAR	20_23444001_C_T
##blood	Gene_EXP:P4HB	2_71427045_G_A
##blood	Gene_EXP:PABPC4L	15_75266048_A_G
##blood	Gene_EXP:PATZ1	17_39270861_TA_T
##blood	Gene_EXP:PAWR	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
##blood	Gene_EXP:PCYOX1L	5_122946014_G_GT
##blood	Gene_EXP:PDGFA	14_57481656_A_C
##blood	Gene_EXP:PDIA5	2_43676215_T_C,11_18534402_T_C
##blood	Gene_EXP:PDZD2	22_32238890_G_A
##blood	Gene_EXP:PELI2	11_63382198_CA_C,13_37746457_TAA_TA,18_21530536_TA_T,6_152444591_GA_G,19_11301321_TA_T
##blood	Gene_EXP:PELI2	13_37746457_TAA_TA,18_21530536_TA_T,19_11301321_TA_T,16_57460490_GA_G,2_53919250_GA_G
##blood	Gene_EXP:PERP	6_167373419_T_C,8_100924055_G_A
##blood	Gene_EXP:PHACTR2	5_146013801_C_T
##blood	Gene_EXP:PIDD	19_7937889_G_A
##blood	Gene_EXP:PIK3CB	2_42288248_A_G,5_16474706_T_G
##blood	Gene_EXP:PIK3R3	2_53919250_GA_G
##blood	Gene_EXP:PITPNM2	7_22308257_T_G,17_42729015_C_A
##blood	Gene_EXP:PLA2G12A	1_70189288_A_C
##blood	Gene_EXP:PLA2G16	11_71605554_A_C
##blood	Gene_EXP:PLAGL1	7_93426338_G_A,11_118551711_A_G,14_104792556_A_G,16_28902389_G_T
##blood	Gene_EXP:PLCB2	7_128805316_G_A
##blood	Gene_EXP:PLEC	2_219488439_G_C,2_219489820_G_A,2_219496348_TC_T,2_219496868_T_TA
##blood	Gene_EXP:PPIP5K2	2_178769706_G_T,11_129905704_C_T
##blood	Gene_EXP:PPT1	11_85898919_C_T
##blood	Gene_EXP:PRAM1	2_178769706_G_T,2_232380380_A_G,7_128805316_G_A
##blood	Gene_EXP:PRCP	3_53179641_T_C
##blood	Gene_EXP:PREP	22_32225632_C_T
##blood	Gene_EXP:PRKAR2A	13_37746457_TAA_TA,18_74804139_CT_C,13_37746457_TA_T,7_73465568_GA_G,12_107746489_GT_G
##blood	Gene_EXP:PRKCQ	9_33796659_C_T,9_33796705_C_G,9_33798019_A_G
##blood	Gene_EXP:PRSS57	9_33796659_C_T
##blood	Gene_EXP:PSTPIP2	2_182063828_G_C,6_143760631_C_A,6_143772215_C_T
##blood	Gene_EXP:PTGFRN	5_126804830_T_C,5_126836282_C_T,11_1250937_C_T
##blood	Gene_EXP:PTK7	2_202765379_CT_C
##blood	Gene_EXP:PTPN12	14_99909370_C_T
##blood	Gene_EXP:PTPRN2	2_106424833_G_C
##blood	Gene_EXP:PVRL2	17_999610_T_C
##blood	Gene_EXP:RAB31	3_75338856_G_A
##blood	Gene_EXP:RAB39B	8_2102806_A_G
##blood	Gene_EXP:RAB9B	5_133070239_CT_C,11_63382198_CA_C,10_67956845_TA_T,13_37746457_TAA_TA,18_21530536_TA_T
##blood	Gene_EXP:RABGAP1	3_10260372_A_G,17_20204460_T_C,17_20205876_C_T,17_20357788_A_G
##blood	Gene_EXP:RABGAP1L	10_93057060_T_C,10_93064409_G_A
##blood	Gene_EXP:RAD54L	1_109669334_C_T
##blood	Gene_EXP:RAG1	4_105719027_C_A,19_11301321_TA_T
##blood	Gene_EXP:RAG2	3_112112876_TA_T,12_21806064_CA_C,19_11301321_TA_T
##blood	Gene_EXP:RALGPS1	7_100098747_C_G
##blood	Gene_EXP:RBM10	6_163478762_CT_C,7_77937691_AT_A,8_108228149_GA_G
##blood	Gene_EXP:RBM15B	5_75576972_GA_G,8_73582883_GA_G,10_67956845_TA_T,11_63382198_CA_C
##blood	Gene_EXP:RBM18	10_131944182_G_C
##blood	Gene_EXP:REPS2	1_32780201_C_G,1_32817174_C_A,16_67140459_A_G,16_67146210_G_C
##blood	Gene_EXP:RFX3	7_67238251_A_AT
##blood	Gene_EXP:RHPN2	12_57456154_A_C
##blood	Gene_EXP:RIPK2	11_63382198_CA_C,6_152444591_GA_G,5_75576972_GA_G,10_67956845_TA_T,5_64507681_TA_T
##blood	Gene_EXP:RIPK2	11_63382198_CA_C,6_152444591_GA_G,5_75576972_GA_G,10_67956845_TA_T,9_120989554_CT_C
##blood	Gene_EXP:RIPK2	6_152444591_GA_G,5_75576972_GA_G,5_64507681_TA_T,10_67956845_TA_T,9_120989554_CT_C
##blood	Gene_EXP:RNF13	10_69097096_G_A
##blood	Gene_EXP:RNF169	6_119180436_T_TAA
##blood	Gene_EXP:RNF24	5_179863845_T_G
##blood	Gene_EXP:RNF38	14_94038937_C_G
##blood	Gene_EXP:ROPN1L	2_200876848_T_C,16_33978977_C_T
##blood	Gene_EXP:ROR2	15_41184658_C_CTT
##blood	Gene_EXP:RRAGA	1_32091885_A_G,7_128815862_G_A,14_24233583_C_T
##blood	Gene_EXP:RUNX1	9_33796659_C_T,9_33796705_C_G
##blood	Gene_EXP:S100A6	12_125519394_A_T
##blood	Gene_EXP:S100A8	12_11091570_G_A
##blood	Gene_EXP:S1PR2	1_204261453_G_A,3_54386725_A_G
##blood	Gene_EXP:SDC4	1_24074187_A_G
##blood	Gene_EXP:SEC61G	19_2073455_A_C
##blood	Gene_EXP:SEMA4B	22_19180296_A_C
##blood	Gene_EXP:SEPHS1	2_232087433_CT_C
##blood	Gene_EXP:SGCA	6_73823468_G_T
##blood	Gene_EXP:SGCE	5_149320388_T_C,10_46549870_A_G,10_46550021_C_T,10_46550133_C_A,10_46550822_T_C
##blood	Gene_EXP:SGPP1	1_153645034_CT_C
##blood	Gene_EXP:SGSM2	2_63842143_GA_G,4_84631729_G_T,7_77256452_A_G,13_97982483_AT_A,16_84054421_T_C
##blood	Gene_EXP:SH2B3	6_167373419_T_C
##blood	Gene_EXP:SKA3	6_163478762_CT_C
##blood	Gene_EXP:SLAMF7	19_48498343_A_G
##blood	Gene_EXP:SLC25A29	5_70067144_CA_C,7_28494775_GT_G,11_63382198_CA_C,12_25215659_AT_A,21_32744756_GA_G
##blood	Gene_EXP:SLC25A37	2_182063828_G_C
##blood	Gene_EXP:SLC30A4	3_39068885_T_TA,3_39078124_T_C,22_39032391_C_G
##blood	Gene_EXP:SLC38A1	7_114653804_G_T
##blood	Gene_EXP:SLC38A5	9_34257981_C_T,22_38962032_A_C,10_104299143_G_T,10_11525272_G_A,10_11852222_GAC_G
##blood	Gene_EXP:SLC4A7	10_128102802_C_A
##blood	Gene_EXP:SLFN11	1_215675245_T_C
##blood	Gene_EXP:SLFN5	2_17592257_G_A,4_186199057_C_A,6_116125413_A_G
##blood	Gene_EXP:SMARCE1	6_38951533_A_G
##blood	Gene_EXP:SMYD2	6_26443625_C_A
##blood	Gene_EXP:SNRNP48	8_108228149_GA_G,13_37746457_TAA_TA,18_21530536_TA_T,16_57460490_GA_G,15_50725184_GT_G
##blood	Gene_EXP:SNRPG	7_12377736_T_C
##blood	Gene_EXP:SNX29	3_54386725_A_G
##blood	Gene_EXP:SOCS1	13_24501721_C_T
##blood	Gene_EXP:SOX4	6_152444591_GA_G,13_37746457_TAA_TA,17_39270861_TA_T
##blood	Gene_EXP:SPNS3	9_33796705_C_G
##blood	Gene_EXP:SPTAN1	21_36253713_C_T
##blood	Gene_EXP:SSR3	8_26634739_T_G,16_23445257_T_C
##blood	Gene_EXP:STMN1	1_109668049_G_T,1_109669334_C_T
##blood	Gene_EXP:STOX1	9_67192757_GA_G
##blood	Gene_EXP:SURF4	14_101856659_C_G
##blood	Gene_EXP:SYNGR1	1_149055998_GA_G,19_52434956_A_G
##blood	Gene_EXP:TAF3	1_75148689_A_T
##blood	Gene_EXP:TATDN3	2_87757451_T_TAA
##blood	Gene_EXP:TEAD3	3_15432008_G_A,3_15434504_C_G
##blood	Gene_EXP:THEM4	2_53919250_GA_G,13_37746457_TAA_TA,18_74804139_CT_C,1_108982799_TA_T,1_74576942_TA_T
##blood	Gene_EXP:TMEM150A	10_88602550_CT_C
##blood	Gene_EXP:TMEM173	1_201199371_G_A,1_201200426_T_G
##blood	Gene_EXP:TMEM52	1_129285_G_A,1_46286376_A_G,10_119136515_G_A,13_33063792_T_G
##blood	Gene_EXP:TMEM87B	9_39118208_G_T,9_41938349_G_T,9_61081995_G_T,X_141906251_C_A
##blood	Gene_EXP:TMEM97	2_113939939_A_G
##blood	Gene_EXP:TMPRSS15	21_39898596_C_A
##blood	Gene_EXP:TNFRSF12A	13_98826885_T_C,19_39902109_T_G
##blood	Gene_EXP:TNFRSF1A	6_71969190_A_G,15_34381982_T_C,15_34528203_T_C,16_46710765_T_A
##blood	Gene_EXP:TNS3	12_6856900_T_C,19_14388545_T_A
##blood	Gene_EXP:TOM1L1	5_32053643_T_C,11_117136643_A_G,11_117207940_T_C
##blood	Gene_EXP:TRIM26	11_129905704_C_T
##blood	Gene_EXP:TSPO	19_53224139_T_C
##blood	Gene_EXP:TSPYL2	2_42288248_A_G,11_33881066_C_A
##blood	Gene_EXP:TTC17	10_43164088_C_T,11_18534354_C_G
##blood	Gene_EXP:TTF1	8_28850105_GA_G,11_63382198_CA_C,6_152444591_GA_G,7_73465568_GA_G,13_37746457_TAA_TA
##blood	Gene_EXP:TTF1	8_28850105_GA_G,12_48679260_CA_C,11_63382198_CA_C,6_152444591_GA_G,13_37746457_TAA_TA
##blood	Gene_EXP:TXLNB	20_56366031_C_T
##blood	Gene_EXP:TYMS	9_5557708_T_C
##blood	Gene_EXP:UBA52	6_135037778_G_A
##blood	Gene_EXP:UBASH3B	14_68477626_CT_C
##blood	Gene_EXP:UBE2H	9_33798075_C_T,9_33798077_T_C,9_33799000_T_C
##blood	Gene_EXP:UPK1B	15_75266055_T_G
##blood	Gene_EXP:USF1	1_225419673_GA_G,9_120989554_CT_C,20_34750522_TA_T,6_99369823_GA_G,17_46332538_GT_G
##blood	Gene_EXP:USP49	7_147638841_CT_C
##blood	Gene_EXP:VPS37C	3_160416453_CT_C,5_146267624_CT_C,12_15623289_TA_T,13_37746457_TA_T
##blood	Gene_EXP:VWA5A	9_98229148_C_A,X_30236259_T_C,X_30242885_A_G,X_30243041_G_C
##blood	Gene_EXP:WT1	9_33796659_C_T,9_33796705_C_G,9_33798019_A_G
##blood	Gene_EXP:YES1	1_16580833_G_T
##blood	Gene_EXP:YIPF5	18_63655761_T_C
##blood	Gene_EXP:ZADH2	4_86769845_A_G
##blood	Gene_EXP:ZBED4	7_100590017_T_G,17_39270861_TA_T,22_23698377_AT_A
##blood	Gene_EXP:ZBTB44	16_8916969_TA_T
##blood	Gene_EXP:ZBTB8OS	10_63177655_C_T,10_63217126_T_G,11_118198037_T_C,19_54632388_T_A,19_54632531_T_C
##blood	Gene_EXP:ZC4H2	1_225419673_GA_G,9_120989554_CT_C,13_24781827_GTT_GT,13_37746457_TAA_TA,19_1057777_GA_G
##blood	Gene_EXP:ZDHHC20	11_47588455_A_C,21_38451144_T_G
##blood	Gene_EXP:ZDHHC23	10_115315580_T_G
##blood	Gene_EXP:ZMYND11	2_100964113_G_A
##blood	Gene_EXP:ZNF22	2_97507111_G_A
##blood	Gene_EXP:ZNF223	8_7564464_G_A
##blood	Gene_EXP:ZNF367	12_48679260_CA_C
##blood	Gene_EXP:ZNF415	1_225147359_GT_G,19_1057777_GA_G
##blood	Gene_EXP:ZNF445	9_33796659_C_T
##blood	Gene_EXP:ZNF566	12_84892141_T_TA
##blood	Gene_EXP:ZNF84	22_46326503_T_C,22_46328661_T_C
##blood	Gene_EXP:ZYX	11_129905704_C_T

[표 2]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value)를 산출한 결과가 아래 [표 3]에 정리되어있다.

또한, [표 2]에 제시된 FRH들이 포함되어 발현된 유전자와 각각의 blood(혈액암) 약물과의 상관도(P-value)를 산출한 결과가 도 25에 도시되어 있다.

Correlation between gene expression and FRH

Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)
CDT1	2.24E-11	DENND4A	1.50E-05	WRAP73	0.000115123
MYB	2.44E-11	SLC38A1	1.51E-05	PTGER4	0.000115506
CCND3	5.21E-10	SEC11C	1.52E-05	ELK4	0.000115691
PREPL	7.23E-10	ZNF256	1.55E-05	MVP	0.00011611
NUCB2	7.97E-10	KIF3C	1.55E-05	NEURL1B	0.000116508
UBE2Q2	9.98E-10	PRKAR2A	1.60E-05	IFIH1	0.000116942
RUNX1	1.07E-09	ZNF646	1.60E-05	SP100	0.000118334
H2AFY	2.75E-09	MCL1	1.61E-05	MGLL	0.000119368
PTPLA	3.51E-09	TMEM38A	1.62E-05	PRSS57	0.000120273
GLUL	3.60E-09	ZNF35	1.65E-05	TGFBR2	0.000120393
SLC25A29	7.76E-09	RBMX	1.69E-05	MAP2K1	0.000121231
VAV3	9.36E-09	KANSL3	1.72E-05	ARHGDIB	0.000123184
SNX25	1.57E-08	LAIR1	1.79E-05	SMPD1	0.000123341
ALYREF	1.62E-08	POLR2M	1.82E-05	PCNA	0.00012346
RAD54L	1.72E-08	TFEB	1.83E-05	TAOK2	0.000123929
CARHSP1	1.80E-08	S1PR3	1.83E-05	ST3GAL4	0.000125195
TCF7L2	2.52E-08	DDR2	1.86E-05	CHEK1	0.000126423
RNF32	2.60E-08	SGCE	1.89E-05	FBXO5	0.00012702
UBASH3B	2.75E-08	CCDC64B	2.01E-05	NFE2L3	0.00012708
UBE2H	2.95E-08	NUDCD3	2.02E-05	KIF21A	0.000127235
OSGEP	2.96E-08	TMEM140	2.04E-05	HMGB3	0.000127631
C19orf77	3.86E-08	C9orf3	2.05E-05	KCNAB1	0.000128089
PHC2	3.89E-08	ZNF833P	2.06E-05	ZNF569	0.000129369
WT1	4.04E-08	PCIF1	2.07E-05	DGAT1	0.000129727
HAUS1	4.17E-08	IGLL1	2.12E-05	PNPLA4	0.000129867
SLC25A12	4.53E-08	ITSN2	2.13E-05	FN3KRP	0.000130689
DAPP1	4.97E-08	C1orf56	2.14E-05	TUBA4A	0.000130725
SCYL3	5.09E-08	KIF20A	2.16E-05	BUD13	0.000130762
STK4	5.19E-08	EHMT2	2.18E-05	ARHGAP11A	0.000131047
TSC22D1	5.26E-08	SYNGR3	2.22E-05	LMO3	0.000131418
TOP2B	5.76E-08	ZNF74	2.23E-05	CRY1	0.000131553
SPOPL	5.85E-08	UNK	2.26E-05	ZNRD1	0.000131923
MAZ	5.89E-08	SENP2	2.27E-05	OR8B4	0.000132203
ATOX1	6.14E-08	IFITM2	2.28E-05	MEX3D	0.000132767
ZNF629	6.72E-08	B4GALT3	2.28E-05	GCAT	0.000133105
HECW2	6.91E-08	STMN3	2.30E-05	C11orf24	0.000134285
KDM1A	8.64E-08	SPRY2	2.37E-05	FZD2	0.000134912
ISM1	9.26E-08	HLA-DPA1	2.38E-05	MGAT4A	0.000134952
NUP43	9.90E-08	ATP6V1A	2.38E-05	TXNDC15	0.000135053
ETS2	1.06E-07	CFLAR	2.39E-05	TBP	0.000135496
RECQL4	1.09E-07	OAS1	2.39E-05	TNIP1	0.000136722
RNF13	1.19E-07	MINA	2.41E-05	LIPC	0.000136982
MPP1	1.25E-07	WNT10A	2.41E-05	PARK7	0.000137199
PRKCQ	1.36E-07	FAM50A	2.43E-05	ADAR	0.000137944
RNASEH2B	1.36E-07	MTX2	2.45E-05	DNASE2	0.000141611
PHF10	1.41E-07	RHBDF2	2.45E-05	ZBTB42	0.000142063
RPL41	1.42E-07	TSG101	2.47E-05	ZCCHC6	0.00014212
IFI30	1.43E-07	EFCAB2	2.48E-05	KIAA1967	0.000142316
IDH2	1.44E-07	NRIP1	2.51E-05	GLMN	0.000142965
ASH2L	1.58E-07	DDX20	2.58E-05	ZC4H2	0.000143482
DCLRE1B	1.63E-07	MAP3K8	2.64E-05	PAN3	0.000143522
BRD3	1.69E-07	MRPL18	2.64E-05	MMS22L	0.000143694
PFKM	1.81E-07	TP63	2.66E-05	FRAT2	0.000144348
GFI1	1.93E-07	KIAA0226	2.68E-05	VSIG10	0.000145524
PATZ1	2.26E-07	IRF5	2.73E-05	FCGRT	0.000147028
RASGRP3	2.28E-07	HNRNPF	2.75E-05	SGMS1	0.000147633
KATNB1	2.37E-07	SEC61G	2.76E-05	SPATA24	0.000148628
CENPQ	2.37E-07	ITGA5	2.76E-05	SNRNP48	0.000149135
TBCD	2.38E-07	ZNF689	2.78E-05	ITGB7	0.000149254
SKA3	2.39E-07	MSL2	2.78E-05	ZNF22	0.000153719
CLEC11A	2.50E-07	SPIN1	2.79E-05	FCGR2B	0.000153896
TMEM168	2.53E-07	C20orf194	2.79E-05	C6orf1	0.000155625
TANK	2.56E-07	TROVE2	2.83E-05	NUPL2	0.000157222
JARID2	2.72E-07	ATG4A	2.84E-05	NBEAL1	0.000157544
IGFBP2	2.81E-07	FANCI	2.85E-05	KCNA4	0.000158213
FADS2	2.82E-07	SPINK13	2.86E-05	HMGXB4	0.000159072
UBE2Z	2.87E-07	CHAF1A	2.96E-05	NKAP	0.000159503
OSBPL5	2.89E-07	PKMYT1	3.02E-05	CEND1	0.00016015
NAMPT	2.93E-07	HIRIP3	3.02E-05	ACSL1	0.000161613
POLD1	2.98E-07	RNASEH2A	3.03E-05	XPR1	0.000162755
IDS	3.40E-07	INCENP	3.08E-05	WBSCR22	0.000162853
MCM10	3.41E-07	EHD4	3.08E-05	ZNF470	0.000163123
UBAC2	3.46E-07	DOK5	3.10E-05	DCAF8	0.000164168
CDCA7	3.51E-07	TAPBP	3.12E-05	POR	0.000166118
LIG1	3.51E-07	APEX1	3.14E-05	GCNT2	0.000166383
RANBP9	3.66E-07	C16orf54	3.22E-05	BLM	0.000167754
RAD51	3.68E-07	ZMIZ2	3.22E-05	SLC24A1	0.000168344
ZNF792	3.93E-07	TRPC4AP	3.24E-05	ADAM19	0.000171567
CAPRIN1	4.03E-07	ELL2	3.26E-05	MDFI	0.00017231
GNPDA2	4.68E-07	C20orf112	3.26E-05	CNDP2	0.000172977
STMN1	4.78E-07	PAWR	3.28E-05	VRK1	0.000174187
NT5C3	4.85E-07	ASNS	3.30E-05	CHST11	0.000174193
NUP85	5.06E-07	FOXRED2	3.30E-05	AACS	0.000175647
MFN1	5.15E-07	FAM69B	3.34E-05	CDC6	0.000176833
NASP	5.31E-07	ZDHHC18	3.48E-05	RUFY1	0.000178547
RHOQ	5.50E-07	HIPK1	3.48E-05	SHARPIN	0.00018061
ZNF184	5.78E-07	METTL15	3.52E-05	LRP10	0.000181626
SBDS	5.82E-07	FLAD1	3.54E-05	NR6A1	0.000182065
ZNF250	5.93E-07	MED13L	3.54E-05	RAG2	0.000182484
AEBP1	5.95E-07	TRIM24	3.55E-05	ZNF469	0.000183243
DGCR8	6.16E-07	CCDC110	3.55E-05	SLC9A7	0.000183326
CYTIP	6.39E-07	USP1	3.59E-05	CEBPE	0.000183435
MYO1C	6.57E-07	LGALS14	3.62E-05	CDK6	0.000184923
TNFRSF10A	6.93E-07	OGDH	3.63E-05	FAM69A	0.000186654
FAM102B	7.09E-07	SAMHD1	3.64E-05	HMGB1	0.0001874
ALG13	7.85E-07	FAM135A	3.67E-05	SEC62	0.000188793
GNA15	7.90E-07	CMTM3	3.68E-05	SETD6	0.000188956
TGIF1	8.24E-07	STK25	3.68E-05	MACC1	0.000190661
ATP6V0A1	8.54E-07	HIVEP1	3.75E-05	LILRB1	0.00019221
CPEB4	8.61E-07	LPAR6	3.75E-05	NANP	0.000192436
PIK3C2A	8.67E-07	PPCDC	3.76E-05	STYXL1	0.000192965
MLF1IP	8.94E-07	KCNN3	3.78E-05	MTA2	0.000192996
SLC25A4	9.08E-07	MRPL36	3.80E-05	RHPN1	0.000193971
NFKBIE	9.17E-07	LEPROTL1	3.82E-05	SERPINA9	0.000195369
SLC41A2	9.65E-07	TARS2	3.85E-05	SASS6	0.000195868
SOX4	1.13E-06	SYNGR2	3.85E-05	RCL1	0.000195962
GMFG	1.19E-06	FSTL1	3.87E-05	PARVG	0.000195977
PLXND1	1.19E-06	SEPHS1	3.88E-05	ATXN7L1	0.000200232
RCOR1	1.22E-06	FBXL19	3.92E-05	BASP1	0.000200326
ILDR1	1.29E-06	CCSAP	3.96E-05	DUSP6	0.000201438
PPP4R1	1.29E-06	WASF1	3.98E-05	CENPC1	0.000201563
THEM4	1.38E-06	CASP8AP2	3.98E-05	SCD5	0.000202694
PELI1	1.42E-06	CTBP2	4.00E-05	S1PR2	0.000203139
CTSZ	1.46E-06	SLMAP	4.09E-05	PRIM2	0.000203384
MBTPS2	1.46E-06	DUSP22	4.09E-05	SSU72	0.000203498
EWSR1	1.47E-06	PSEN2	4.20E-05	STX12	0.000203691
SNRPA	1.51E-06	NKD2	4.21E-05	ZFP161	0.000205341
CNTROB	1.53E-06	CNOT4	4.30E-05	KIF3B	0.000205553
CBLN3	1.55E-06	NMRK1	4.32E-05	SRSF6	0.000205578
ICAM1	1.56E-06	CYTH2	4.38E-05	ARHGAP24	0.000208463
IFT122	1.61E-06	NDUFB5	4.38E-05	WHSC1L1	0.000209197
ZBED4	1.63E-06	P4HTM	4.41E-05	HCCS	0.000209644
CDC45	1.66E-06	SCAF8	4.44E-05	TRAF3IP2	0.000211478
KCNK6	1.69E-06	NFS1	4.45E-05	MKNK2	0.000212936
FAM126A	1.74E-06	CHTF18	4.46E-05	MRPS14	0.000215752
C1GALT1C1	1.75E-06	ERMN	4.52E-05	SLC26A2	0.000218439
POC1A	1.79E-06	LRFN4	4.63E-05	KPNA4	0.000219219
TUBGCP3	1.83E-06	UNG	4.66E-05	FAM117B	0.000220464
SCCPDH	1.94E-06	IL21R	4.69E-05	FAM167A	0.000221601
ABL1	2.04E-06	RNF169	4.78E-05	IVNS1ABP	0.000222418
MEX3B	2.06E-06	TCTN1	4.80E-05	TRADD	0.000223089
MRPL32	2.11E-06	APBA3	4.81E-05	MGST2	0.000224188
RNF138	2.13E-06	GINS4	4.82E-05	ZNF431	0.000224682
KMO	2.15E-06	MANBAL	4.85E-05	CCNJ	0.000225117
PMVK	2.15E-06	COPS3	4.93E-05	C7orf13	0.000225587
SV2A	2.18E-06	B3GNTL1	4.93E-05	KDM3B	0.000226832
POLE	2.18E-06	BTBD3	4.97E-05	ZSWIM7	0.000227768
AZI1	2.20E-06	MAPK1	5.01E-05	SSR3	0.000228274
CD86	2.21E-06	COA6	5.06E-05	NLRP7	0.000233295
MAPK14	2.23E-06	METTL17	5.07E-05	ZNF146	0.000235932
MCM3	2.28E-06	TLR10	5.11E-05	KIFC1	0.000238208
ESD	2.51E-06	ZNF8	5.16E-05	TIGD5	0.000238343
BAHCC1	2.53E-06	ELOVL5	5.24E-05	MAN1A1	0.000241281
ARHGEF6	2.56E-06	SHANK3	5.25E-05	ZBTB8OS	0.000243537
AFTPH	2.56E-06	C4orf51	5.26E-05	ODF3B	0.000244509
SLFN11	2.59E-06	FAM108B1	5.28E-05	WDR17	0.000244958
ZNF599	2.61E-06	RNF130	5.30E-05	ZNF791	0.000247285
ZNF784	2.65E-06	ATAD5	5.39E-05	FOXK2	0.000248927
DDAH2	2.71E-06	H2AFX	5.44E-05	ZBTB45	0.000249672
BIRC3	2.74E-06	SRP72	5.44E-05	CHCHD10	0.0002508
ETV3	2.90E-06	WT1-AS	5.46E-05	MPP6	0.000250805
KIAA0101	3.00E-06	KIF15	5.55E-05	HOXB7	0.000252206
ATAD2	3.07E-06	CCNE2	5.61E-05	IFNGR2	0.000252921
ZBTB38	3.12E-06	BPNT1	5.64E-05	BAG6	0.000257524
HNRNPA0	3.16E-06	LMNB1	5.66E-05	PUF60	0.000259229
CD274	3.24E-06	IFT88	5.70E-05	UBE2Q1	0.000259259
CNOT6	3.36E-06	RAB36	5.81E-05	AKT1S1	0.000259587
PHF7	3.67E-06	GBA2	5.85E-05	TNRC6C	0.000260508
HLA-DMB	3.68E-06	LYPLAL1	5.86E-05	ZNF428	0.000260664
VAT1	3.76E-06	LCP2	5.88E-05	ZBTB32	0.000261656
MRPS33	3.89E-06	CEP85	5.90E-05	SQSTM1	0.000261872
CNOT8	3.94E-06	NUAK2	5.95E-05	ZNF32	0.000262217
REM2	4.02E-06	RREB1	5.95E-05	ADSL	0.000262672
VOPP1	4.10E-06	TNFRSF13B	5.97E-05	SMARCE1	0.000263249
CENPB	4.23E-06	TTC12	5.98E-05	GARS	0.000264164
FPGS	4.32E-06	HLA-DOB	5.99E-05	GIN1	0.000264788
RELB	4.46E-06	ACBD4	6.07E-05	EBI3	0.000265758
RUVBL2	4.54E-06	SEL1L	6.08E-05	MKS1	0.000267062
POLDIP3	4.60E-06	TNFRSF10B	6.08E-05	GABARAPL2	0.000269298
NCOA3	4.61E-06	PPIH	6.09E-05	FCRLB	0.00026953
RAD51AP1	4.83E-06	RUNX3	6.10E-05	CYBA	0.000270356
RAD50	4.93E-06	BAIAP2L1	6.12E-05	TAX1BP1	0.000271579
CAMSAP2	4.98E-06	CDC7	6.17E-05	C1orf228	0.000272967
IGF1	5.06E-06	SH2B2	6.23E-05	OR10A4	0.000274609
CCDC14	5.11E-06	ZBP1	6.25E-05	OAS2	0.000276321
SLAMF7	5.11E-06	PLAUR	6.27E-05	DTL	0.000278068
TRIM28	5.12E-06	PTOV1	6.28E-05	TTLL1	0.000278962
SLC26A11	5.12E-06	MATK	6.30E-05	NOC3L	0.000279403
PELI2	5.13E-06	LEPRE1	6.33E-05	C16orf80	0.000280058
RFC5	5.24E-06	SPNS3	6.35E-05	EVC	0.000281524
NRM	5.32E-06	NUP160	6.43E-05	DNMT3B	0.000283535
TMEM5	5.33E-06	UGGT2	6.43E-05	TTC37	0.000283545
MCCC2	5.33E-06	RRNAD1	6.43E-05	ZNF304	0.000283609
MCM6	5.37E-06	KLHL18	6.47E-05	UBLCP1	0.000284509
ACTN1	5.40E-06	NOG	6.47E-05	NFKBIA	0.000285765
MAGEC1	5.41E-06	GAB2	6.50E-05	ZNF77	0.000287023
MIS18A	5.42E-06	CEP57L1	6.53E-05	SLC2A8	0.000287583
ACBD3	5.47E-06	IRF4	6.54E-05	ACIN1	0.000287686
ORC1	5.56E-06	CBX6	6.57E-05	ZAP70	0.000289508
DNAJC10	5.69E-06	LUZP1	6.62E-05	CDC20	0.000289907
CYLD	5.78E-06	GLTSCR2	6.78E-05	CIITA	0.000292068
ITM2B	6.14E-06	NIPSNAP3A	6.79E-05	ZFYVE28	0.000294965
UNC13C	6.23E-06	PTK7	6.84E-05	MCEE	0.000294965
GINS1	6.24E-06	MTF2	6.88E-05	CCBL2	0.000295541
ATAT1	6.27E-06	C3orf52	6.89E-05	EGFL7	0.000295762
KIF22	6.27E-06	PLCXD1	6.98E-05	RPTOR	0.000296802
AIM2	6.34E-06	PRIM1	7.03E-05	YKT6	0.000297043
LDOC1L	6.35E-06	HDAC2	7.03E-05	MED10	0.000297618
DHX36	6.47E-06	GADD45B	7.04E-05	YIPF4	0.000298798
HERPUD1	6.50E-06	VPS26B	7.09E-05	ECE1	0.000300247
PTGES3L-AARSD1	6.52E-06	TOX	7.12E-05	SEC14L1	0.00030148
ISG20	6.65E-06	HIST1H4C	7.17E-05	DPY19L4	0.000301874
CTSS	6.76E-06	SMUG1	7.17E-05	SERPINI1	0.000306367
CXXC4	6.76E-06	MAML1	7.19E-05	BUB3	0.000307406
OST4	6.77E-06	MAD2L2	7.24E-05	RALBP1	0.00030814
FADS1	6.80E-06	ZNF219	7.28E-05	SUMO3	0.000308982
DNM1	6.86E-06	SRRT	7.29E-05	SKAP2	0.000310288
SLC25A44	7.10E-06	TUBA1B	7.32E-05	NPC1L1	0.000310435
TYMS	7.37E-06	CPXM1	7.34E-05	PRMT2	0.000310513
TXNDC11	7.45E-06	RILP	7.44E-05	ATP11A	0.000311389
SP140	7.52E-06	ZNF69	7.57E-05	HLA-DRA	0.000311878
PEA15	7.67E-06	AURKAIP1	7.68E-05	NOD1	0.000312979
HNRNPUL1	7.69E-06	PARP2	7.69E-05	KLHDC3	0.000313518
THAP6	8.32E-06	DNM2	7.78E-05	ADH1A	0.000314539
BRIP1	8.46E-06	CDC42SE1	7.78E-05	POLE2	0.000316263
MIOS	8.58E-06	ACVR2A	7.79E-05	KCNQ1	0.00031951
SYAP1	8.63E-06	TUBB	7.79E-05	SPIN4	0.000322002
BRD1	8.88E-06	FYB	7.80E-05	BST2	0.000324476
RAP2C	9.02E-06	NRXN1	7.96E-05	ZNF616	0.000324868
ZDBF2	9.02E-06	TAS2R8	7.98E-05	TRIM13	0.000325141
PSRC1	9.06E-06	GTPBP10	8.17E-05	RBM15B	0.000325377
EIF2C4	9.07E-06	ZWINT	8.23E-05	MAP4K1	0.00032544
DBN1	9.11E-06	DMD	8.31E-05	DPH3	0.000326699
TNFRSF1A	9.25E-06	FRAT1	8.32E-05	MRPL33	0.000328039
NMRAL1	9.30E-06	ZMYM1	8.35E-05	SLC25A32	0.000328338
SPATS2	9.42E-06	MAP4K4	8.43E-05	PPP6R1	0.000328581
ZNRF1	9.56E-06	MTPN	8.44E-05	HEY1	0.000332424
STK33	9.64E-06	ARHGAP19	8.54E-05	CNR1	0.000333937
ZNF627	9.73E-06	PAPPA2	8.58E-05	RHOBTB2	0.000337846
CALCRL	9.82E-06	DDX60L	8.63E-05	CASKIN2	0.000342224
PCYT1A	9.85E-06	WDFY2	8.63E-05	MUL1	0.000342995
MRPL40	9.98E-06	AKIRIN2	8.66E-05	NFAT5	0.000344167
KAT7	1.01E-05	REPS1	8.68E-05	WDHD1	0.000348001
C12orf60	1.02E-05	UBR7	8.73E-05	ORMDL2	0.000348388
AIFM2	1.04E-05	TIPARP	8.73E-05	SPHK1	0.000350761
SMARCD2	1.06E-05	DCAF6	8.79E-05	SF3A3	0.000350835
ANKIB1	1.06E-05	ZNF566	8.88E-05	TTLL7	0.000351437
DTD1	1.08E-05	ZNF367	9.02E-05	CASC5	0.000352269
DNAJB2	1.08E-05	RTN4R	9.12E-05	IRX5	0.000352846
ZNF230	1.11E-05	RNF24	9.15E-05	C10orf25	0.000353021
LRRC16A	1.13E-05	CMIP	9.17E-05	CDKN2B	0.000355938
SGSH	1.13E-05	CCR10	9.24E-05	TMEM62	0.00035702
DIAPH1	1.14E-05	SNX29	9.28E-05	ERCC5	0.0003614
EML4	1.15E-05	C17orf85	9.35E-05	FAAH2	0.000363537
TSC22D3	1.15E-05	COMMD1	9.36E-05	OR10H2	0.000363576
HYI	1.16E-05	ZNF512B	9.41E-05	TRAF4	0.000363601
PPP1R2	1.16E-05	HP1BP3	9.46E-05	SLC20A2	0.000364092
DUSP5	1.16E-05	STEAP1	9.51E-05	AKAP13	0.000365223
FAM98A	1.17E-05	ZNF606	9.53E-05	CDK2	0.000365579
SCIN	1.18E-05	XPC	9.58E-05	FBXO34	0.000366966
KCNA2	1.19E-05	TONSL	9.64E-05	P2RX1	0.000367307
CELF5	1.20E-05	WDR5	9.74E-05	CCNY	0.000368265
TEX9	1.20E-05	C12orf5	9.82E-05	CCRL2	0.000368709
ZNF114	1.20E-05	CEP70	9.89E-05	PORCN	0.000370299
TOMM7	1.20E-05	PRR3	9.96E-05	KIT	0.000371032
PAFAH1B3	1.23E-05	SFXN3	0.0001	INHBE	0.000372554
MED12	1.24E-05	CTDSPL	0.0001	ZNF626	0.000373433
CD48	1.28E-05	HNRNPA3	0.0001	GATAD1	0.000374764
GNAQ	1.28E-05	GPATCH1	0.0001	PSMB4	0.000375032
PPFIBP2	1.28E-05	PITPNM2	0.0001	ARL6	0.000375706
NFKB2	1.32E-05	RHPN2	0.00011
RALA	1.32E-05	UVRAG	0.00011
MCM4	1.33E-05	ZNF181	0.00011
GTF3C5	1.35E-05	POU2F2	0.00011
C7orf63	1.36E-05	C1GALT1	0.00011
ANKRD50	1.38E-05	HPS4	0.00011
TMEM44	1.40E-05	LSP1	0.00011
TNFRSF17	1.42E-05	TICAM1	0.00011
CD74	1.43E-05	ZNF382	0.00011
FNBP1L	1.47E-05	IKZF3	0.00012

이들 [표 3] 및 [도 25]로부터 [표 3] 및 [도 25]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 혈액암 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

여성암(breast, ovary) 약물에 대한 반응성 바이오 마커

Cancer_Class	Gene_exp	바이오 마커(발현조절 FRH 변이세트)
##breast, ovary	Gene_EXP:ADCY7	16_15664876_A_C
##breast, ovary	Gene_EXP:AFAP1L2	2_39717176_T_G
##breast, ovary	Gene_EXP:ASB8	19_35904227_A_C
##breast, ovary	Gene_EXP:ASGR2	6_138499187_A_G,10_38696926_C_T
##breast, ovary	Gene_EXP:C2CD2L	1_158255229_C_G
##breast, ovary	Gene_EXP:CA5B	9_133696445_G_T
##breast, ovary	Gene_EXP:CACHD1	2_240030066_G_A
##breast, ovary	Gene_EXP:CAPN13	6_88143916_C_T
##breast, ovary	Gene_EXP:CAPN8	2_206144039_C_A,2_206160720_T_C,2_206176329_T_C,4_118752896_G_GA
##breast, ovary	Gene_EXP:CCDC64B	4_9244322_A_T
##breast, ovary	Gene_EXP:CHRNA5	3_196708735_G_GA
##breast, ovary	Gene_EXP:CLDN4	6_143503967_G_T
##breast, ovary	Gene_EXP:CMIP	16_85071785_A_G
##breast, ovary	Gene_EXP:CTSL1	3_138124252_C_T,12_12480353_A_G,14_95124733_G_A,17_18028570_C_CAA
##breast, ovary	Gene_EXP:DNAJC18	2_140485313_A_T,2_140485349_T_C
##breast, ovary	Gene_EXP:EFS	19_30444797_C_A
##breast, ovary	Gene_EXP:EME2	7_108180467_G_T
##breast, ovary	Gene_EXP:FAM83E	5_71204405_A_C
##breast, ovary	Gene_EXP:GALNTL5	10_100352318_A_G,15_34255437_A_T
##breast, ovary	Gene_EXP:HBEGF	9_61862148_G_A
##breast, ovary	Gene_EXP:HIST2H2BE	6_132814681_A_G
##breast, ovary	Gene_EXP:HMGA1	20_49248835_G_A,20_49270147_G_A
##breast, ovary	Gene_EXP:HS3ST1	19_17422317_A_G
##breast, ovary	Gene_EXP:IBA57	1_21472921_G_A,10_50850592_T_TTG,17_76280234_G_A
##breast, ovary	Gene_EXP:ILF3	3_49256393_C_G,X_52516974_A_C
##breast, ovary	Gene_EXP:ITGA6	7_74046648_T_G
##breast, ovary	Gene_EXP:JAG1	3_122461164_C_G,3_122552357_T_TA,3_122558313_G_T,3_122558325_G_A,8_138636921_T_C
##breast, ovary	Gene_EXP:KCNK5	18_8831617_G_A
##breast, ovary	Gene_EXP:KIFC2	22_23966980_A_G
##breast, ovary	Gene_EXP:MAFB	11_90202418_G_T,11_90206280_G_A
##breast, ovary	Gene_EXP:NECAB2	19_57254064_A_G
##breast, ovary	Gene_EXP:NECAB3	3_49256393_C_G,14_19827899_G_T
##breast, ovary	Gene_EXP:P2RY2	5_169294_T_C,17_60211184_A_G
##breast, ovary	Gene_EXP:PALMD	2_109615723_C_G
##breast, ovary	Gene_EXP:PLXNA3	1_113114916_G_A
##breast, ovary	Gene_EXP:PPP3CC	1_111414895_T_C,1_111414948_G_C
##breast, ovary	Gene_EXP:PREX1	9_34371054_A_C
##breast, ovary	Gene_EXP:PRR12	6_38813973_C_T
##breast, ovary	Gene_EXP:PRRT3	12_57763713_A_C
##breast, ovary	Gene_EXP:QSER1	1_15381304_A_C,13_79521022_A_T
##breast, ovary	Gene_EXP:REEP5	14_77243033_A_C
##breast, ovary	Gene_EXP:RGS2	18_12978734_C_G
##breast, ovary	Gene_EXP:RNF208	4_7815971_GT_G,19_11832898_G_A
##breast, ovary	Gene_EXP:RNF43	21_33262774_CT_C
##breast, ovary	Gene_EXP:S100A2	14_64950352_C_A,19_17422317_A_G
##breast, ovary	Gene_EXP:SERPINE1	1_17240836_G_T,X_156025548_C_T
##breast, ovary	Gene_EXP:SGTB	9_74785802_T_C
##breast, ovary	Gene_EXP:SLC19A1	11_1607735_G_A
##breast, ovary	Gene_EXP:SLC26A1	1_237511850_A_AG
##breast, ovary	Gene_EXP:SOAT1	7_108180467_G_T
##breast, ovary	Gene_EXP:TMEM206	2_108378352_C_G,14_106335417_A_C,14_106360128_A_C
##breast, ovary	Gene_EXP:TMPRSS3	2_118981693_C_T,2_135636088_A_G,2_135638730_T_C,16_71998332_T_A
##breast, ovary	Gene_EXP:TNFRSF21	20_8802237_G_A
##breast, ovary	Gene_EXP:TOX2	1_116133184_T_G
##breast, ovary	Gene_EXP:TRMT2A	17_76280234_G_A
##breast, ovary	Gene_EXP:YBX2	5_80320470_T_G,19_4770616_T_G,1_204257913_A_C,14_105919516_A_C,1_181798372_A_C
##breast, ovary	Gene_EXP:ZMYND11	13_72746754_A_C,14_77243033_A_C
##breast, ovary	Gene_EXP:ZNF239	10_35032587_A_C
##breast, ovary	Gene_EXP:ABLIM1	4_70158293_T_TACAA
##breast, ovary	Gene_EXP:ADK	3_57269656_A_G
##breast, ovary	Gene_EXP:ARHGAP10	3_119212542_C_T
##breast, ovary	Gene_EXP:BEND4	19_2917289_C_A
##breast, ovary	Gene_EXP:C9orf50	6_30713139_C_T
##breast, ovary	Gene_EXP:CSRP3	6_33801120_A_G
##breast, ovary	Gene_EXP:DEFB124	4_183444992_C_T,6_107334154_A_C,6_107459275_C_G,6_107459279_A_G
##breast, ovary	Gene_EXP:DIAPH1	7_74734035_C_T,13_31758155_C_G
##breast, ovary	Gene_EXP:DOK7	3_38580976_T_C
##breast, ovary	Gene_EXP:ETS1	5_139680901_G_A
##breast, ovary	Gene_EXP:FBXO10	7_72961358_G_A,7_73180651_C_T,7_75212025_G_A,7_75403732_C_T,17_63918839_T_A
##breast, ovary	Gene_EXP:GAS8	13_39724501_TA_T
##breast, ovary	Gene_EXP:GSTCD	2_70236036_TA_T
##breast, ovary	Gene_EXP:HBEGF	4_38137040_C_T
##breast, ovary	Gene_EXP:MDM2	8_89769704_A_C,8_89786745_A_T,8_89786749_T_TC,8_89790263_A_G
##breast, ovary	Gene_EXP:MSTN	12_65210914_C_T
##breast, ovary	Gene_EXP:OLR1	22_39017940_A_C
##breast, ovary	Gene_EXP:PDZD8	2_120289468_AT_A
##breast, ovary	Gene_EXP:PRMT3	3_121809056_C_CT
##breast, ovary	Gene_EXP:PTPN12	7_63297679_T_C
##breast, ovary	Gene_EXP:RAI2	22_31685485_C_A
##breast, ovary	Gene_EXP:RSPH9	2_196215830_T_C,15_42399466_C_G
##breast, ovary	Gene_EXP:SDHAF1	10_35032524_A_C
##breast, ovary	Gene_EXP:SLCO3A1	10_98392420_C_T,10_98420094_T_C
##breast, ovary	Gene_EXP:STAC3	12_65210914_C_T,14_22105305_C_A,15_62835784_G_A,X_299277_G_T
##breast, ovary	Gene_EXP:STOML2	5_154027084_C_T,5_154033830_C_T,5_154053173_T_C
##breast, ovary	Gene_EXP:SYNGR2	17_41830878_T_C
##breast, ovary	Gene_EXP:TMEM106C	7_149253814_T_G
##breast, ovary	Gene_EXP:UBE3B	1_3729650_T_C
##breast, ovary	Gene_EXP:USF2	13_28048219_G_A,13_28049622_C_T,13_28049801_G_GA,20_56365300_T_C
##breast, ovary	Gene_EXP:VASN	X_152750582_A_C
##breast, ovary	Gene_EXP:WFDC2	2_97152499_A_C,2_97152524_G_T,2_97152525_C_G,2_97152527_G_T,2_97152546_G_C
##breast, ovary	Gene_EXP:WNK3	2_86119057_G_A
##breast, ovary	Gene_EXP:ZFP82	11_1243593_T_C
##breast, ovary	Gene_EXP:ZNF302	17_36013794_G_A
##breast, ovary	Gene_EXP:ZNF331	18_36818951_C_T
##breast, ovary	Gene_EXP:ZSCAN18	14_64741308_T_C

[표 4]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value)를 산출한 결과가 아래 [표 5]에 정리되어있다.

또한, [표 4]에 제시된 FRH들이 포함되어 발현된 유전자 중 주요유전자와 각각의 breast, ovary(여성암) 약물과의 상관도(P-value)를 산출한 결과가 아래 도 26에 정리되어있다.

Correlation between gene expression and FRH

Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)
RSPO4	9.21E-09	FERMT1	1.08E-05	RARA	5.78E-05
AMPD3	2.10E-08	MRPL24	1.19E-05	RAB26	5.80E-05
IRX5	3.24E-08	SLC1A2	1.21E-05	COL4A5	5.83E-05
IRX3	1.14E-07	PLAG1	1.30E-05	CASP4	5.86E-05
PCP4	1.69E-07	EPHA2	1.36E-05	XBP1	5.88E-05
TRPS1	2.79E-07	ETFDH	1.36E-05	NUPR1	5.89E-05
ABHD11	3.28E-07	HLF	1.39E-05	ICAM3	5.93E-05
PRLR	3.37E-07	PLAT	1.43E-05	RHOB	5.95E-05
GADD45A	4.40E-07	ZC3H12C	1.46E-05	CAV2	5.95E-05
CRIP2	5.39E-07	PIM1	1.61E-05	SCARB2	6.05E-05
YBX2	5.70E-07	PDXDC1	1.67E-05	MMP14	6.07E-05
TGFB3	6.56E-07	CARD14	1.68E-05	INTS12	6.18E-05
FAM76B	7.97E-07	FGFR4	1.69E-05	LMO3	6.28E-05
SELENBP1	8.09E-07	PKN2	1.78E-05	RGS20	6.28E-05
CISH	8.21E-07	SSBP2	1.78E-05	A1BG	6.31E-05
PREX1	1.01E-06	PEX11B	1.79E-05	HPX	6.33E-05
DIXDC1	1.05E-06	CDCP1	1.85E-05	KCNJ4	6.34E-05
PHLDA1	1.18E-06	PPP4R1	1.95E-05	CLUAP1	6.45E-05
OLFM1	1.35E-06	IL17RC	2.01E-05	ACTN1	6.47E-05
ITGA6	1.36E-06	SLC16A6	2.07E-05	ANXA6	6.48E-05
F12	1.44E-06	HPN	2.33E-05	PDCD4	6.52E-05
CGREF1	1.45E-06	SUSD1	2.36E-05	KNCN	6.56E-05
UBE2E3	1.62E-06	TRMT12	2.36E-05	ATP10A	6.56E-05
LARGE	1.69E-06	COTL1	2.58E-05	CCDC117	6.59E-05
PDZRN3	2.01E-06	KCTD3	2.62E-05	LCA5	6.75E-05
MAPK8IP2	2.08E-06	PLCH1	2.63E-05	GLYATL1	6.85E-05
SOGA2	2.14E-06	ARNTL2	2.68E-05	ENTPD2	6.92E-05
PPFIA3	2.34E-06	CCDC50	2.73E-05	HS3ST1	6.97E-05
SERF2	2.60E-06	CDC14B	2.75E-05	CPEB3	7.07E-05
LTBP2	2.70E-06	SEPP1	2.85E-05	TGIF1	7.20E-05
ZNF324B	2.98E-06	PLAU	3.02E-05	PFKFB3	7.28E-05
PRR7	3.00E-06	PLA2G12A	3.07E-05	PI4K2A	7.34E-05
CYB561	3.17E-06	NUDT16L1	3.11E-05	ATP8A1	7.41E-05
MUC5B	3.37E-06	ADCY9	3.23E-05	NUTF2	7.47E-05
NCKAP5	3.39E-06	VPS37D	3.24E-05	NHS	7.53E-05
IGSF5	3.46E-06	FIS1	3.39E-05	WBP5	7.55E-05
MMAA	3.90E-06	UAP1L1	3.41E-05	C9orf152	7.66E-05
ATP2A3	3.93E-06	UFSP1	3.65E-05	LDB1	7.71E-05
CMIP	4.14E-06	CREB3L4	3.77E-05	SMCHD1	7.78E-05
CCDC82	4.26E-06	EIF2B5	3.78E-05	NAV2	7.80E-05
NFE2L3	4.56E-06	AMZ1	3.82E-05	PTPRM	7.84E-05
UTS2R	4.84E-06	PIP	3.83E-05	OPRD1	7.91E-05
HMGA1	5.12E-06	NKX6-3	3.88E-05	KMO	7.96E-05
STK24	5.27E-06	PPARG	4.06E-05	PFKFB1	7.97E-05
ITGA3	5.71E-06	VGLL3	4.32E-05	SLC2A4	8.19E-05
NT5E	6.11E-06	TP53I11	4.34E-05	ZNF598	8.33E-05
NPNT	6.20E-06	PRRT2	4.47E-05	TENC1	8.34E-05
NFAT5	6.34E-06	NUBP2	4.52E-05	OSBPL3	8.43E-05
ATP6V1F	6.44E-06	LAMC2	4.53E-05	TMEM106A	8.46E-05
NOL3	6.78E-06	RSPH1	4.73E-05	SPDEF	8.54E-05
TNS1	7.24E-06	DEFB132	4.85E-05	TTC39A	8.56E-05
TMEM192	7.31E-06	NECAB3	4.92E-05	DGAT1	8.76E-05
DECR2	7.48E-06	RAB3A	4.96E-05	FAM63A	8.81E-05
TMEM141	7.49E-06	SLC24A3	4.99E-05	LMCD1	8.82E-05
PBX1	7.55E-06	CA12	5.03E-05	EGFR	8.83E-05
ZNF467	7.62E-06	TC2N	5.09E-05	TUBGCP2	8.89E-05
CIB3	7.96E-06	NINJ1	5.28E-05	RHBDD3	9.00E-05
ECHDC3	8.00E-06	DNAJC22	5.31E-05	TFPI2	9.01E-05
CHRM1	8.78E-06	ARPC2	5.35E-05	STK32B	9.02E-05
DNAAF1	8.98E-06	ITGBL1	5.38E-05	GSTCD	9.11E-05
FYN	9.41E-06	CCDC149	5.39E-05	RGL2	9.42E-05
INPP1	9.73E-06	DERL1	5.40E-05	NDUFB9	9.43E-05
AAK1	9.84E-06	UPP1	5.60E-05	SYCP2	9.47E-05
SPRY2	1.05E-05	ELK3	5.63E-05	CBX4	9.49E-05
REM1	1.06E-05	SAMD9	5.68E-05	DLG2	9.56E-05
TTYH2	1.07E-05	ARL4C	5.71E-05	KIF12	9.70E-05

이들 [표 4-1] 및 [도 26]으로부터 [표 4-1] 및 [도 26]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 여성암 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

brain(뇌종양) 약물에 대한 반응성 바이오 마커

Cancer_Class	Gene_exp	바이오 마커 (발현조절 FRH 변이세트)
##brain	Gene_EXP:VN1R1	1_213007133_T_G
##brain	Gene_EXP:PCDH9	3_75669056_G_A
##brain	Gene_EXP:AADAT	11_12162199_T_G
##brain	Gene_EXP:FILIP1L	2_117977926_TAGTC_T
##brain	Gene_EXP:VPRBP	3_128945112_G_A
##brain	Gene_EXP:PDCD1LG2	3_165019547_G_T,11_12162199_T_G
##brain	Gene_EXP:AARS2	2_211420614_AAAAG_A
##brain	Gene_EXP:FKBP14	16_72119226_C_G
##brain	Gene_EXP:VSTM2A	13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:PDCD2L	1_150558532_T_C,2_196880031_T_C
##brain	Gene_EXP:ABAT	3_51381020_A_G,3_197683305_A_C,16_24930679_T_G,19_18216930_A_C
##brain	Gene_EXP:FKBP15	3_128945112_G_A,X_2856636_A_C,19_4911043_A_C,5_181155466_T_G,8_122952205_T_G
##brain	Gene_EXP:WASF1	2_108507561_T_G,10_43200831_A_G,16_55415_T_G
##brain	Gene_EXP:PDGFA	2_66439901_A_C
##brain	Gene_EXP:ABCC3	16_87644643_G_A,17_55774876_T_G,3_133839473_T_G,1_44804312_T_G,8_7290003_A_C
##brain	Gene_EXP:WDR1	10_11921140_T_G,13_113159942_A_G,16_1817242_T_C,18_79527652_GAA_G
##brain	Gene_EXP:PDP1	1_248441636_T_G
##brain	Gene_EXP:FLII	1_213007133_T_G,2_86027990_C_A,12_51745916_T_G,16_1342948_A_C
##brain	Gene_EXP:PDSS1	5_180624003_T_C,12_40313960_G_T
##brain	Gene_EXP:ABCC3	6_29588459_T_G,1_154331414_T_G,12_40313960_G_T,17_7797836_A_C,7_149253814_T_G
##brain	Gene_EXP:FLNA	13_113159942_A_G,16_1817242_T_C,10_11921140_T_G,1_15381304_A_C,20_34750204_T_G
##brain	Gene_EXP:PDXDC1	1_248061096_A_G
##brain	Gene_EXP:PDXK	16_72164743_G_A
##brain	Gene_EXP:ABCC8	3_128945112_G_A
##brain	Gene_EXP:WDR12	6_29588459_T_G,1_154331414_T_G,7_149253814_T_G,12_40313960_G_T,17_7797836_A_C
##brain	Gene_EXP:FLNA	16_1817242_T_C,3_100302035_G_T,8_122952205_T_G,13_113159942_A_G,15_84241166_A_C
##brain	Gene_EXP:PEA15	8_7290003_A_C,5_181155466_T_G,10_50311228_T_G,2_60761746_T_G,11_12162199_T_G
##brain	Gene_EXP:ABHD12	2_190469793_G_C
##brain	Gene_EXP:WDR12	6_29588459_T_G,17_7797836_A_C,3_142177436_A_G,1_154331414_T_G,17_73202973_G_T
##brain	Gene_EXP:ABHD2	20_31465452_G_A,20_31476528_A_G
##brain	Gene_EXP:FLNA	20_34750204_T_G,10_79312556_A_G,15_84241166_A_C,16_1817242_T_C,3_100302035_G_T
##brain	Gene_EXP:PEBP1	4_108762737_T_G
##brain	Gene_EXP:ACOT9	3_128945112_G_A,6_29631350_A_G,10_11921140_T_G,11_12162199_T_G,13_113159942_A_G
##brain	Gene_EXP:PEX5	2_96842345_G_C
##brain	Gene_EXP:WDR18	1_64663808_A_C
##brain	Gene_EXP:FLNB	19_15878967_A_C
##brain	Gene_EXP:PFDN2	1_200988322_T_G
##brain	Gene_EXP:WDR3	5_88722571_GA_G,10_5909062_T_C
##brain	Gene_EXP:ACP1	2_86604885_C_A,2_113934259_C_T,5_181155466_T_G,11_12162199_T_G,19_3281403_A_C
##brain	Gene_EXP:FLVCR1	10_11921140_T_G,11_12162199_T_G
##brain	Gene_EXP:PGAP1	11_65547388_T_G,13_113159942_A_G
##brain	Gene_EXP:WDR75	2_190469793_G_C,1_154331414_T_G,3_196782572_G_T,7_149253814_T_G,18_14183954_G_T
##brain	Gene_EXP:FOSL1	1_213007133_T_G,12_51745916_T_G,12_57062993_T_G,13_39724512_C_T
##brain	Gene_EXP:PHACTR3	16_30953637_A_C
##brain	Gene_EXP:ACSL4	11_33583339_C_T,11_33583414_C_T,11_33606557_T_G
##brain	Gene_EXP:WDR86	16_87644643_G_A,19_9566733_T_G,20_42084724_T_C
##brain	Gene_EXP:PHF11	11_12162199_T_G,X_2856636_A_C,X_119150617_A_C
##brain	Gene_EXP:ACTB	11_12162199_T_G
##brain	Gene_EXP:FSD1L	11_12162199_T_G,11_65547388_T_G,13_113159942_A_G
##brain	Gene_EXP:WHAMM	2_113934259_C_T
##brain	Gene_EXP:PHF21B	11_12162199_T_G,13_113159942_A_G,16_1817242_T_C,16_30953637_A_C
##brain	Gene_EXP:ACTL6B	2_105307612_A_C,11_43920052_A_C,13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:FTL	5_69653664_G_C
##brain	Gene_EXP:WIPI1	1_155709773_T_G,2_127651579_A_C
##brain	Gene_EXP:FUBP1	16_28169801_A_C
##brain	Gene_EXP:PHF5A	1_54243266_A_G,15_82430191_A_C,11_12162199_T_G,17_737856_G_T,20_18142912_A_C
##brain	Gene_EXP:ACTN2	1_213007133_T_G
##brain	Gene_EXP:WNK2	10_11921140_T_G
##brain	Gene_EXP:FUCA1	1_153341603_A_C,11_12162199_T_G
##brain	Gene_EXP:ACTN4	1_213007133_T_G,10_73803641_A_G,11_12162199_T_G,12_51745916_T_G
##brain	Gene_EXP:WNT5A	11_65547388_T_G
##brain	Gene_EXP:FUCA2	1_185150475_G_A,X_54813054_T_G
##brain	Gene_EXP:PHF5A	5_140841707_A_C,1_54243266_A_G,17_737856_G_T,15_82430191_A_C,20_18142912_A_C
##brain	Gene_EXP:WWC3	16_70661204_T_G,8_27431326_A_G,17_7797836_A_C,19_4911043_A_C,20_63999659_A_C
##brain	Gene_EXP:G6PD	16_87644643_G_A
##brain	Gene_EXP:ACTR5	2_96842345_G_C,2_178663651_C_T
##brain	Gene_EXP:GAB2	1_451649_A_AG
##brain	Gene_EXP:PHIP	12_40313960_G_T,15_55329691_T_C,15_55340661_G_T
##brain	Gene_EXP:ACVR1B	2_113934259_C_T,5_181155466_T_G,10_79312556_A_G,11_12162199_T_G,12_6818898_A_C
##brain	Gene_EXP:WWC3	19_4911043_A_C,17_7797836_A_C,19_15113629_A_C,16_70661204_T_G,14_93183653_A_C
##brain	Gene_EXP:GABRB3	2_15474280_T_C,2_15534562_T_C,13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:PHOX2A	12_51745916_T_G
##brain	Gene_EXP:PHYHIPL	13_113159942_A_G,16_30953637_A_C
##brain	Gene_EXP:ACVR2B	3_128945112_G_A,13_113159942_A_G,11_34452090_T_G,16_1817242_T_C,11_65547388_T_G
##brain	Gene_EXP:WWTR1	3_128945112_G_A,10_11921140_T_G,16_1817242_T_C
##brain	Gene_EXP:GADD45B	11_12162199_T_G,12_51745916_T_G
##brain	Gene_EXP:PIEZO1	13_113159942_A_G
##brain	Gene_EXP:XPC	20_62396250_G_C
##brain	Gene_EXP:GAL	2_66439901_A_C,9_37887606_C_T
##brain	Gene_EXP:ACVR2B	3_128945112_G_A,16_1817242_T_C,13_113159942_A_G,11_34452090_T_G,10_11921140_T_G
##brain	Gene_EXP:PIK3C2B	7_45038379_G_A,9_121300007_T_G,10_11921140_T_G
##brain	Gene_EXP:XPO5	11_65547388_T_G,15_75524142_T_C
##brain	Gene_EXP:GAL3ST3	16_55415_T_G,X_100585180_G_T,19_7740447_T_G,2_113934259_C_T,10_79312556_A_G
##brain	Gene_EXP:PIKFYVE	2_32465180_C_T
##brain	Gene_EXP:XRCC2	2_219297298_T_G
##brain	Gene_EXP:ADAM10	17_63963708_T_C
##brain	Gene_EXP:PINK1	17_55774876_T_G
##brain	Gene_EXP:XRCC5	20_42084724_T_C
##brain	Gene_EXP:GALNT10	6_30705792_T_G,11_65547388_T_G,12_40313960_G_T
##brain	Gene_EXP:ADAM9	3_165019547_G_T,10_11921140_T_G,11_12162199_T_G,12_51745916_T_G,5_181155466_T_G
##brain	Gene_EXP:PKIA	13_113159942_A_G
##brain	Gene_EXP:YEATS4	1_12001708_A_G,6_31966660_T_G,12_6818898_A_C,19_9566733_T_G
##brain	Gene_EXP:GAS6	1_2303248_C_T,1_154331414_T_G,1_156912285_A_C
##brain	Gene_EXP:PKIG	2_105307612_A_C,10_46337735_A_G,10_47523038_G_A
##brain	Gene_EXP:GATA2	13_113159942_A_G
##brain	Gene_EXP:ADAM9	3_165019547_G_T,10_11921140_T_G,11_12162199_T_G,12_51745916_T_G,8_122952205_T_G
##brain	Gene_EXP:YIPF2	2_113934259_C_T
##brain	Gene_EXP:PLAUR	7_72942379_A_C,11_12162199_T_G,12_51745916_T_G
##brain	Gene_EXP:GBA	10_11921140_T_G,13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:YTHDC1	11_12162199_T_G
##brain	Gene_EXP:PLEC	7_72942379_A_C,10_11921140_T_G,10_79312556_A_G,12_51745916_T_G
##brain	Gene_EXP:ADAM9	3_165019547_G_T,11_12162199_T_G,10_11921140_T_G,5_181155466_T_G,12_51745916_T_G
##brain	Gene_EXP:GBE1	19_47441156_T_G,10_11921140_T_G,16_58525116_G_T,8_7290003_A_C,5_181155466_T_G
##brain	Gene_EXP:ZBED4	2_108507561_T_G,11_65547388_T_G
##brain	Gene_EXP:PLEKHA4	7_2269556_T_A
##brain	Gene_EXP:ZBTB34	3_165019547_G_T
##brain	Gene_EXP:ADAMTS12	17_81695118_T_G,10_45773152_T_G,8_120342359_T_G,12_45173236_T_G,10_45773156_T_G
##brain	Gene_EXP:GBE1	8_122952205_T_G,11_73355795_A_G,14_93183653_A_C,5_181155466_T_G,19_47441156_T_G
##brain	Gene_EXP:PLEKHF2	7_108023984_G_A
##brain	Gene_EXP:ZBTB39	16_30953637_A_C
##brain	Gene_EXP:ADAMTS17	13_113159942_A_G
##brain	Gene_EXP:PLIN3	11_12162199_T_G
##brain	Gene_EXP:GBE1	8_122952205_T_G,14_93183653_A_C,5_181155466_T_G,19_47441156_T_G,19_9566733_T_G
##brain	Gene_EXP:ZBTB4	6_30705792_T_G,10_11921140_T_G,17_55774876_T_G
##brain	Gene_EXP:ADAMTSL2	8_122952205_T_G,9_136745293_A_C,14_20996722_T_G
##brain	Gene_EXP:PLK2	3_9688859_C_T,5_127331576_G_A
##brain	Gene_EXP:ZBTB47	16_58526137_A_C
##brain	Gene_EXP:GBP1	11_12162199_T_G
##brain	Gene_EXP:ADRBK2	11_65547388_T_G,17_78476773_C_T
##brain	Gene_EXP:PLOD1	2_113934259_C_T
##brain	Gene_EXP:ZBTB7A	3_14704350_G_A
##brain	Gene_EXP:GBP2	11_12162199_T_G
##brain	Gene_EXP:AGA	2_66439901_A_C,22_18345089_T_G
##brain	Gene_EXP:PLOD2	2_66439901_A_C
##brain	Gene_EXP:ZC3H15	2_154854926_A_C,3_196782572_G_T,7_149253814_T_G,20_63929447_G_C
##brain	Gene_EXP:GBP3	8_7290003_A_C,12_40313960_G_T,15_75524142_T_C
##brain	Gene_EXP:AGAP1	12_44376797_G_A,13_113159942_A_G,11_65547388_T_G,16_48133728_A_G,3_115720911_A_C
##brain	Gene_EXP:PLP2	5_181155466_T_G,6_33296240_C_A,8_30756677_T_G,12_104287190_A_G
##brain	Gene_EXP:GCNT1	8_41957277_G_C,10_89402920_C_T
##brain	Gene_EXP:ZC3H8	11_12162199_T_G
##brain	Gene_EXP:AGBL5	1_224250187_A_G
##brain	Gene_EXP:PLSCR4	16_55415_T_G,17_51169925_C_T
##brain	Gene_EXP:GDAP1L1	13_113159942_A_G,16_1817242_T_C,9_128835995_A_C,11_125626705_T_G,16_30953637_A_C
##brain	Gene_EXP:ZC3HAV1	1_149852603_A_G
##brain	Gene_EXP:AGPAT3	1_183963850_T_G,11_65547388_T_G,13_113159942_A_G
##brain	Gene_EXP:PMEL	20_42084724_T_C
##brain	Gene_EXP:ZCCHC12	1_1676790_C_T,6_43052450_G_A
##brain	Gene_EXP:GDPD1	9_69516199_A_C
##brain	Gene_EXP:AGTPBP1	11_65547388_T_G,13_113159942_A_G
##brain	Gene_EXP:PML	11_12162199_T_G
##brain	Gene_EXP:ZCCHC24	12_6818898_A_C
##brain	Gene_EXP:GFPT2	1_12938859_G_A,7_72942379_A_C
##brain	Gene_EXP:AHNAK	10_79312556_A_G
##brain	Gene_EXP:PNMA3	1_149852603_A_G,16_18379704_T_G,20_16044565_T_G,16_55415_T_G,22_17727059_T_G
##brain	Gene_EXP:ZDHHC17	1_248638477_A_T
##brain	Gene_EXP:GFRA2	5_38950065_A_T,16_30953637_A_C
##brain	Gene_EXP:ALKBH2	19_3281403_A_C,16_30953637_A_C,11_12162199_T_G,8_27431326_A_G,1_228244520_T_G
##brain	Gene_EXP:ZDHHC7	2_27449240_T_G
##brain	Gene_EXP:PNMA3	1_149852603_A_G,16_18379704_T_G,20_16044565_T_G,22_17727059_T_G,16_55415_T_G
##brain	Gene_EXP:GGCX	16_1817242_T_C
##brain	Gene_EXP:ZFYVE21	22_42212334_A_C
##brain	Gene_EXP:ALKBH2	19_3281403_A_C,16_30953637_A_C,8_27431326_A_G,10_73803641_A_G,11_12162199_T_G
##brain	Gene_EXP:GIGYF2	17_55774876_T_G
##brain	Gene_EXP:ZHX3	2_27449240_T_G,6_31648729_A_C
##brain	Gene_EXP:PNN	13_39724512_C_T
##brain	Gene_EXP:GINM1	4_154328181_A_C,7_72942379_A_C,10_73803641_A_G,11_12162199_T_G
##brain	Gene_EXP:ZNF121	11_12162199_T_G,13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:ALPK2	11_12162199_T_G,12_40313960_G_T,22_19918884_A_C
##brain	Gene_EXP:POC5	12_9304133_T_C,12_31094748_T_C,Y_11344922_A_G
##brain	Gene_EXP:ZNF124	2_170965958_A_C,13_113159942_A_G,17_55774876_T_G
##brain	Gene_EXP:AMFR	1_150464600_A_C,1_185150475_G_A,21_46245172_A_C,10_97432342_T_G,17_57116234_T_G
##brain	Gene_EXP:PODXL2	12_51745916_T_G,13_113159942_A_G
##brain	Gene_EXP:GLB1	1_54243266_A_G,1_219979389_T_A,7_72942379_A_C
##brain	Gene_EXP:ZNF195	2_113934259_C_T,12_40313960_G_T,12_51745916_T_G
##brain	Gene_EXP:POFUT1	4_118640836_A_T
##brain	Gene_EXP:GLB1L2	2_113934259_C_T,7_108023984_G_A
##brain	Gene_EXP:ZNF219	15_43716974_A_C
##brain	Gene_EXP:ANKMY2	12_51745916_T_G
##brain	Gene_EXP:POFUT2	7_95495738_CT_C,16_72119226_C_G,16_72164743_G_A
##brain	Gene_EXP:GLCCI1	13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:ZNF266	16_14644660_C_T
##brain	Gene_EXP:ANKRD40	4_9908299_G_A
##brain	Gene_EXP:POLD1	17_36104042_G_T,19_9566733_T_G
##brain	Gene_EXP:GLI3	16_83602507_A_G
##brain	Gene_EXP:ZNF280B	11_65547388_T_G
##brain	Gene_EXP:ANKRD46	10_11921140_T_G
##brain	Gene_EXP:POLG2	19_4911043_A_C,22_22098988_G_T
##brain	Gene_EXP:GLIPR1	10_11921140_T_G,19_4911043_A_C
##brain	Gene_EXP:ZNF32	1_89186388_T_C,1_89186389_C_T
##brain	Gene_EXP:ANO6	3_9928758_C_T
##brain	Gene_EXP:POLR1B	12_40313960_G_T
##brain	Gene_EXP:GLIS3	2_66439901_A_C,8_7290003_A_C,8_41957277_G_C,10_50311228_T_G,11_65547388_T_G
##brain	Gene_EXP:ZNF367	7_30778382_G_A
##brain	Gene_EXP:ANXA1	13_113159942_A_G,16_1817242_T_C,10_11921140_T_G,2_113934259_C_T,5_181155466_T_G
##brain	Gene_EXP:POLR1C	16_14868419_C_A
##brain	Gene_EXP:ZNF420	13_113159942_A_G
##brain	Gene_EXP:GLTP	1_149852603_A_G,2_61492168_C_A
##brain	Gene_EXP:POLR1D	2_206705805_G_C,8_12430448_C_T
##brain	Gene_EXP:ANXA1	13_113159942_A_G,16_1817242_T_C,10_11921140_T_G,5_181155466_T_G,12_51745916_T_G
##brain	Gene_EXP:ZNF507	11_65547388_T_G,17_55774876_T_G
##brain	Gene_EXP:GNA12	7_129389033_T_G,12_51745916_T_G,13_113325626_T_C
##brain	Gene_EXP:POLR2B	20_31864041_C_T
##brain	Gene_EXP:ZNF516	1_234373536_T_G,3_184301903_T_G,9_37887606_C_T,17_55774876_T_G
##brain	Gene_EXP:GNAI2	1_149852603_A_G,1_150261398_T_G,17_55774876_T_G,17_77213881_T_G,1_154627925_A_C
##brain	Gene_EXP:PON2	10_11921140_T_G,13_113159942_A_G,16_1817242_T_C,19_3281403_A_C
##brain	Gene_EXP:ANXA11	16_1817242_T_C
##brain	Gene_EXP:ANXA2	2_86604885_C_A,5_181155466_T_G,6_33296240_C_A,8_30756677_T_G,12_57178583_A_C
##brain	Gene_EXP:ZNF561	2_9954863_A_G
##brain	Gene_EXP:GNAI2	1_149852603_A_G,1_150261398_T_G,17_55774876_T_G,5_181155466_T_G,17_77213881_T_G
##brain	Gene_EXP:POU2F1	12_51745916_T_G
##brain	Gene_EXP:ZNF562	1_43984998_A_C
##brain	Gene_EXP:PPAP2A	5_133233474_T_G,12_57244313_A_C
##brain	Gene_EXP:ANXA4	6_33799054_A_G,8_27431326_A_G,8_30756677_T_G,19_11402175_A_C
##brain	Gene_EXP:ZNF589	10_73803641_A_G
##brain	Gene_EXP:GNAI2	1_150261398_T_G,5_181155466_T_G,1_149852603_A_G,17_55774876_T_G,17_77213881_T_G
##brain	Gene_EXP:PPAPDC2	7_44964464_T_C,7_45064532_G_A
##brain	Gene_EXP:ZNF607	1_9735624_A_C,3_128945112_G_A,11_12162199_T_G
##brain	Gene_EXP:PPAT	14_55169342_TAAA_T,1_46261223_G_A,1_228244520_T_G,2_154854926_A_C,6_56557393_C_T
##brain	Gene_EXP:ANXA5	5_181155466_T_G,9_69516199_A_C,12_51745916_T_G,13_113325635_A_G
##brain	Gene_EXP:GNB5	22_17727059_T_G
##brain	Gene_EXP:ZNF638	5_427675_T_C,10_73803531_T_C,13_39724512_C_T,22_17727059_T_G
##brain	Gene_EXP:GNG4	13_113159942_A_G
##brain	Gene_EXP:PPAT	14_55169342_TAAA_T,1_46261223_G_A,6_56557393_C_T,8_27431326_A_G,5_141478412_T_C
##brain	Gene_EXP:ANXA7	1_45019269_T_G,17_36608462_A_C,16_1817242_T_C,13_113159942_A_G,5_427675_T_C
##brain	Gene_EXP:ZNF696	12_40313960_G_T
##brain	Gene_EXP:GNPDA2	3_191358113_C_T
##brain	Gene_EXP:ZNF704	11_120836935_C_T
##brain	Gene_EXP:GOLGA4	1_102989661_C_T,6_161149171_A_T
##brain	Gene_EXP:PPFIBP1	8_122952205_T_G,17_1010919_A_C
##brain	Gene_EXP:AP2S1	2_27774175_G_T,2_61492168_C_A,7_100951952_T_A,7_100951953_T_A
##brain	Gene_EXP:ZNF708	1_172308705_AT_A,17_41567189_T_G
##brain	Gene_EXP:GOLPH3	3_128945112_G_A,4_190022208_C_G,10_390794_C_G,10_73803531_T_C
##brain	Gene_EXP:PPIC	2_66439901_A_C
##brain	Gene_EXP:APEX1	17_55774876_T_G
##brain	Gene_EXP:ZNF709	16_24793502_A_C
##brain	Gene_EXP:PPP1CC	1_185150475_G_A,10_11921140_T_G,11_124896232_A_G
##brain	Gene_EXP:GOLT1B	16_72119226_C_G,16_72129067_G_T,16_72164743_G_A
##brain	Gene_EXP:ARF6	1_173850301_T_G
##brain	Gene_EXP:ZNF74	11_65547388_T_G,17_55774876_T_G,2_113934259_C_T,2_61492168_C_A,5_181155466_T_G
##brain	Gene_EXP:PQLC3	10_11921140_T_G,16_18379704_T_G
##brain	Gene_EXP:GPC1	1_54243266_A_G,10_74988957_T_G,17_7797836_A_C,7_75364819_A_C,3_113344632_A_C
##brain	Gene_EXP:ARHGAP1	13_113159942_A_G
##brain	Gene_EXP:PRAME	16_67909562_C_A,19_57720377_A_G,22_42212334_A_C
##brain	Gene_EXP:ZNF74	17_55774876_T_G,11_65547388_T_G,5_181155466_T_G,2_113934259_C_T,1_234373536_T_G
##brain	Gene_EXP:ARHGAP19	14_55169342_TAAA_T
##brain	Gene_EXP:PRCC	2_105307612_A_C,4_9908299_G_A,19_8943580_T_G
##brain	Gene_EXP:GPHN	11_12162199_T_G,13_39724512_C_T
##brain	Gene_EXP:ARID2	11_12162199_T_G,16_72119226_C_G,16_72129067_G_T,16_72164743_G_A
##brain	Gene_EXP:PRICKLE2	11_65547388_T_G
##brain	Gene_EXP:ZNF74	17_55774876_T_G,11_65547388_T_G,5_181155466_T_G,2_61492168_C_A,1_234373536_T_G
##brain	Gene_EXP:GPN2	1_451649_A_AG,1_873548_C_T,17_55774876_T_G
##brain	Gene_EXP:PRIM1	2_218827668_A_C
##brain	Gene_EXP:GPR125	5_181155466_T_G
##brain	Gene_EXP:ARID3B	8_7290003_A_C
##brain	Gene_EXP:PRKAA1	3_128945112_G_A,X_100585180_G_T
##brain	Gene_EXP:ZNF74	17_55774876_T_G,11_65547388_T_G,8_7290003_A_C,1_234373536_T_G,2_61492168_C_A
##brain	Gene_EXP:GPS1	1_111982463_G_A
##brain	Gene_EXP:ARL1	6_25488355_C_T,6_25510468_CAT_C,9_93293047_T_G,12_51745916_T_G,13_113159942_A_G
##brain	Gene_EXP:PRLHR	6_56067480_C_T,10_26746549_C_T
##brain	Gene_EXP:GPX8	13_113159942_A_G,16_72119226_C_G
##brain	Gene_EXP:ZNF781	6_30705792_T_G,11_65547388_T_G
##brain	Gene_EXP:PRMT1	1_26034759_T_G,5_181155466_T_G
##brain	Gene_EXP:ARL6IP5	14_102870248_A_C
##brain	Gene_EXP:GRASP	12_40313960_G_T
##brain	Gene_EXP:ZNF804A	6_73622013_G_C,6_73635330_C_T
##brain	Gene_EXP:PRMT6	3_53872486_G_A,7_35240878_C_T
##brain	Gene_EXP:ARRB2	2_170965958_A_C,20_33848655_A_C
##brain	Gene_EXP:GREB1	11_65547388_T_G
##brain	Gene_EXP:ZNFX1	11_125626705_T_G
##brain	Gene_EXP:PRNP	12_51745916_T_G
##brain	Gene_EXP:ASB13	17_28613683_A_C
##brain	Gene_EXP:GRIA4	13_113159942_A_G
##brain	Gene_EXP:ZNRF3	2_27774175_G_T
##brain	Gene_EXP:PRPF40B	17_64146068_T_G
##brain	Gene_EXP:ASCL1	7_72942379_A_C
##brain	Gene_EXP:GRIK3	3_128945112_G_A
##brain	Gene_EXP:ZSCAN16	16_72119226_C_G
##brain	Gene_EXP:PRPH	1_451649_A_AG
##brain	Gene_EXP:ASPH	2_105307612_A_C
##brain	Gene_EXP:GRPEL2	5_133233474_T_G,9_108900415_C_A,10_11921140_T_G
##brain	Gene_EXP:ZSCAN2	2_61492168_C_A
##brain	Gene_EXP:PRR14L	11_65547388_T_G
##brain	Gene_EXP:ATCAY	13_113159942_A_G,16_1817242_T_C,6_33279455_T_G,16_30953637_A_C,9_5549463_A_C
##brain	Gene_EXP:GSDMD	Gene_EXP:WDR12
##brain	Gene_EXP:PRRC1	15_31037741_G_A,15_31046297_T_G
##brain	Gene_EXP:GSN	5_181155466_T_G,10_11921140_T_G,13_113159942_A_G,15_75524142_T_C,16_1817242_T_C
##brain	Gene_EXP:PRRX1	10_96527504_G_C
##brain	Gene_EXP:ATF7IP2	2_63887264_C_CA,1_149852603_A_G,17_55774876_T_G,10_73803531_T_C,22_17727059_T_G
##brain	Gene_EXP:PRSS23	10_11921140_T_G,13_113325635_A_G
##brain	Gene_EXP:GTF2H5	3_165019547_G_T,16_15664675_G_T
##brain	Gene_EXP:ATF7IP2	2_63887264_C_CA,17_55774876_T_G,1_149852603_A_G,10_73803531_T_C,22_17727059_T_G
##brain	Gene_EXP:PSMB9	10_11921140_T_G,11_12162199_T_G,16_55415_T_G,X_2856636_A_C
##brain	Gene_EXP:GTF3C2	7_128839939_T_G,7_159142364_T_G
##brain	Gene_EXP:GTPBP4	12_40313960_G_T
##brain	Gene_EXP:ATG4A	2_61492168_C_A,2_113934259_C_T,9_35398502_T_G,9_108900415_C_A,16_87644643_G_A
##brain	Gene_EXP:PTHLH	10_11921140_T_G
##brain	Gene_EXP:GUF1	1_213007133_T_G,5_181155466_T_G,11_12162199_T_G,11_65547388_T_G,17_55774876_T_G
##brain	Gene_EXP:PTRF	13_113159942_A_G,10_11921140_T_G,12_57178583_A_C,8_122952205_T_G,11_12162199_T_G
##brain	Gene_EXP:ATIC	7_34811781_C_G,12_40313960_G_T
##brain	Gene_EXP:H1FX	11_73355795_A_G
##brain	Gene_EXP:ATL2	3_38112112_T_G
##brain	Gene_EXP:PTRF	13_113159942_A_G,10_11921140_T_G,6_30705792_T_G,12_57178583_A_C,8_7290003_A_C
##brain	Gene_EXP:H3F3B	13_113325635_A_G
##brain	Gene_EXP:ATL3	13_113159942_A_G
##brain	Gene_EXP:HAUS1	19_9566733_T_G
##brain	Gene_EXP:PTRF	13_113159942_A_G,10_11921140_T_G,6_30705792_T_G,8_7290003_A_C,5_181155466_T_G
##brain	Gene_EXP:ATP2A2	13_113159942_A_G
##brain	Gene_EXP:HBQ1	8_7290003_A_C
##brain	Gene_EXP:ATP2B4	1_12001708_A_G,1_15381304_A_C
##brain	Gene_EXP:HCP5	11_12162199_T_G
##brain	Gene_EXP:PTRF	13_113159942_A_G,10_11921140_T_G,8_7290003_A_C,6_30705792_T_G,5_181155466_T_G
##brain	Gene_EXP:ATP5B	1_54243266_A_G,6_31966660_T_G
##brain	Gene_EXP:HDAC2	14_55169342_TAAA_T,17_55774876_T_G,11_65547388_T_G,7_108023984_G_A,15_75524142_T_C
##brain	Gene_EXP:ATP6V0E1	11_12162199_T_G,12_40313960_G_T,15_43211582_A_C
##brain	Gene_EXP:PTRF	6_30705792_T_G,12_57178583_A_C,8_122952205_T_G,11_94082585_T_C,13_113159942_A_G
##brain	Gene_EXP:ATXN7L3B	15_65451964_A_G,2_108507561_T_G,12_57062993_T_G,2_113934259_C_T,1_213007133_T_G
##brain	Gene_EXP:HDLBP	7_44964464_T_C,7_45064532_G_A
##brain	Gene_EXP:PTRF	6_30705792_T_G,8_122952205_T_G,12_57178583_A_C,11_94082585_T_C,13_113159942_A_G
##brain	Gene_EXP:HEG1	1_54243266_A_G,11_12162199_T_G
##brain	Gene_EXP:ATXN7L3B	15_65451964_A_G,2_108507561_T_G,12_57062993_T_G,2_113934259_C_T,5_181155466_T_G
##brain	Gene_EXP:HEXB	11_12162199_T_G,11_65547388_T_G,15_75876091_T_G
##brain	Gene_EXP:PTTG1IP	1_54243266_A_G,1_154331414_T_G,3_196782572_G_T,6_30642116_A_G,11_12162199_T_G
##brain	Gene_EXP:HFM1	6_73622013_G_C,6_73635330_C_T,10_79312556_A_G,11_12162199_T_G,15_55340661_G_T
##brain	Gene_EXP:ATXN7L3B	15_65451964_A_G,2_108507561_T_G,2_113934259_C_T,12_57062993_T_G,5_181155466_T_G
##brain	Gene_EXP:PUM2	19_3281403_A_C
##brain	Gene_EXP:HIC2	13_98390168_T_C,5_181155466_T_G,8_7290003_A_C,1_54243266_A_G,14_67381608_G_T
##brain	Gene_EXP:AVEN	16_15022595_T_G,5_36255453_A_T,10_50311228_T_G,7_75422659_A_G,14_24437182_T_G
##brain	Gene_EXP:PUS7	11_65547388_T_G
##brain	Gene_EXP:PVRL2	11_12162199_T_G,13_113159942_A_G
##brain	Gene_EXP:HIC2	2_27774175_G_T,10_11921140_T_G,1_54243266_A_G,8_7290003_A_C,13_113325635_A_G
##brain	Gene_EXP:AXL	10_11921140_T_G
##brain	Gene_EXP:PWWP2B	9_37887606_C_T
##brain	Gene_EXP:B2M	3_128945112_G_A,X_2856636_A_C,20_42084724_T_C,13_113325635_A_G,12_6818898_A_C
##brain	Gene_EXP:HIC2	2_27774175_G_T,10_11921140_T_G,13_113325635_A_G,8_7290003_A_C,5_181155466_T_G
##brain	Gene_EXP:PXDC1	7_159142364_T_G,11_65547388_T_G,13_113159942_A_G
##brain	Gene_EXP:RAB11FIP4	12_124473081_C_T,13_113159942_A_G,17_76040867_A_G
##brain	Gene_EXP:B3GNT9	7_108023984_G_A,11_65547388_T_G,15_66561152_T_G,17_55774876_T_G
##brain	Gene_EXP:HIST1H3F	4_88731303_A_G,9_35398502_T_G
##brain	Gene_EXP:HIST3H2A	10_11921140_T_G,16_18379704_T_G,20_16044565_T_G
##brain	Gene_EXP:RAB23	13_113325635_A_G
##brain	Gene_EXP:B4GALT1	11_65547388_T_G,13_113159942_A_G
##brain	Gene_EXP:HIST3H3	7_72830875_T_G
##brain	Gene_EXP:RAB27A	1_150261398_T_G,7_108023984_G_A,7_108024001_C_T,16_20737706_A_C,12_6818898_A_C
##brain	Gene_EXP:BAI3	6_30705792_T_G,13_113159942_A_G
##brain	Gene_EXP:HMG20B	1_150261398_T_G,16_18379704_T_G
##brain	Gene_EXP:BAZ1A	15_65451964_A_G
##brain	Gene_EXP:RAB27A	7_108023984_G_A,1_150261398_T_G,7_108024001_C_T,16_20737706_A_C,12_6818898_A_C
##brain	Gene_EXP:HMGB1	16_72119226_C_G
##brain	Gene_EXP:BCAR3	7_108023984_G_A,10_390794_C_G,11_62576120_A_C,16_18379704_T_G,17_55774876_T_G
##brain	Gene_EXP:HMGB2	1_12001708_A_G,5_181155466_T_G,8_2963284_T_G,19_9566733_T_G
##brain	Gene_EXP:RAB31	7_72942379_A_C
##brain	Gene_EXP:BCCIP	1_219979389_T_A,19_11402175_A_C
##brain	Gene_EXP:RAB32	11_12162199_T_G,12_6818898_A_C
##brain	Gene_EXP:HMGCL	1_16589114_C_T
##brain	Gene_EXP:BCL7A	10_11921140_T_G,11_12162199_T_G,13_113159942_A_G
##brain	Gene_EXP:RAB3A	1_149852603_A_G,1_150261398_T_G,15_75293000_T_G,16_15664675_G_T,13_113325635_A_G
##brain	Gene_EXP:HMGCR	16_1817242_T_C
##brain	Gene_EXP:BCL9L	12_51745916_T_G
##brain	Gene_EXP:HMOX1	12_51745916_T_G
##brain	Gene_EXP:BCLAF1	11_65547388_T_G
##brain	Gene_EXP:RAB3C	8_7290003_A_C,10_11921140_T_G
##brain	Gene_EXP:HNRNPA0	16_55415_T_G,17_55774876_T_G
##brain	Gene_EXP:BEAN1	10_79510669_A_AG,10_80249658_G_GC
##brain	Gene_EXP:RAN	10_11921140_T_G,19_3281403_A_C
##brain	Gene_EXP:HNRNPA1L2	2_113934259_C_T,5_181155466_T_G,7_72942379_A_C,12_40313960_G_T,12_51745916_T_G
##brain	Gene_EXP:BEND3	15_75524142_T_C,15_75876091_T_G
##brain	Gene_EXP:RANBP1	6_30705792_T_G
##brain	Gene_EXP:BEND4	1_150261398_T_G,6_37022626_A_C,2_237368621_T_G,5_181155466_T_G,12_6818898_A_C
##brain	Gene_EXP:RANBP17	20_42084724_T_C
##brain	Gene_EXP:HNRNPC	14_55169342_TAAA_T,17_74350765_T_G,1_108718913_T_G,17_40348252_T_G,19_9566733_T_G
##brain	Gene_EXP:RANBP2	1_16589114_C_T,11_65547388_T_G,15_55329691_T_C
##brain	Gene_EXP:BEND4	6_37022626_A_C,1_150261398_T_G,2_237368621_T_G,5_181155466_T_G,12_6818898_A_C
##brain	Gene_EXP:HNRNPC	14_55169342_TAAA_T,2_169735166_A_C,19_9566733_T_G,5_181155466_T_G,1_108718913_T_G
##brain	Gene_EXP:RAP1GAP2	9_69516199_A_C,11_12162199_T_G,12_112962678_A_C,13_113159942_A_G
##brain	Gene_EXP:BEND6	10_50311228_T_G,17_41725799_T_G
##brain	Gene_EXP:HNRNPH3	1_228244520_T_G,14_55169342_TAAA_T
##brain	Gene_EXP:RAP2C	19_4911043_A_C
##brain	Gene_EXP:BHLHB9	2_224001670_G_A,2_224001859_C_A,3_128908109_T_C,3_128908178_A_G,13_113159942_A_G
##brain	Gene_EXP:HNRNPU	15_65451964_A_G
##brain	Gene_EXP:RARRES3	1_213007133_T_G,12_40313960_G_T,16_87644643_G_A
##brain	Gene_EXP:HNRPDL	17_55774876_T_G
##brain	Gene_EXP:RASL11B	1_220067324_T_G,5_181155466_T_G,9_126483890_T_G,11_73355795_A_G
##brain	Gene_EXP:BHLHE40	11_12162199_T_G,7_72942379_A_C,14_93183653_A_C,8_122952205_T_G,6_30705792_T_G
##brain	Gene_EXP:HOXD8	20_42084724_T_C
##brain	Gene_EXP:RAX	14_64951601_A_C
##brain	Gene_EXP:HPCAL4	12_123194624_A_ATT
##brain	Gene_EXP:BHLHE40	11_12162199_T_G,8_122952205_T_G,6_30705792_T_G,14_93183653_A_C,8_7290003_A_C
##brain	Gene_EXP:RBFOX1	1_213007133_T_G
##brain	Gene_EXP:HPDL	6_41770599_T_G,8_7290003_A_C
##brain	Gene_EXP:BHLHE40	11_12162199_T_G,8_122952205_T_G,6_30705792_T_G,8_7290003_A_C,14_93183653_A_C
##brain	Gene_EXP:RBMX	2_113934259_C_T
##brain	Gene_EXP:HRH1	9_108900415_C_A
##brain	Gene_EXP:RCAN1	2_66439901_A_C,7_159142364_T_G,8_7290003_A_C,11_65547388_T_G
##brain	Gene_EXP:HRH3	3_128945112_G_A,6_33279455_T_G
##brain	Gene_EXP:BHLHE40	8_7290003_A_C,11_12162199_T_G,8_122952205_T_G,6_30705792_T_G,14_93183653_A_C
##brain	Gene_EXP:HS3ST4	3_128945112_G_A
##brain	Gene_EXP:RECK	8_106761354_T_G,10_50311228_T_G
##brain	Gene_EXP:HSF2	1_234373536_T_G,2_178663651_C_T,2_178689190_G_A,11_65547388_T_G,16_67878678_T_G
##brain	Gene_EXP:BHLHE41	2_113934259_C_T
##brain	Gene_EXP:REEP5	2_113934259_C_T,5_181155466_T_G,16_87644643_G_A
##brain	Gene_EXP:BIRC2	12_51745916_T_G
##brain	Gene_EXP:RELB	11_12162199_T_G
##brain	Gene_EXP:HSPA5	1_165652085_TATTATC_T
##brain	Gene_EXP:BLM	19_9566733_T_G
##brain	Gene_EXP:REP15	12_121222019_A_C,2_134946094_C_T,X_130145432_T_G,3_100302035_G_T,11_73355795_A_G
##brain	Gene_EXP:HSPD1	17_55774876_T_G
##brain	Gene_EXP:BLVRB	15_20566681_C_G
##brain	Gene_EXP:HSPG2	1_37703244_A_C,15_84241166_A_C
##brain	Gene_EXP:BMP1	7_72942379_A_C,11_12162199_T_G,17_7797836_A_C
##brain	Gene_EXP:REP15	12_121222019_A_C,5_141102658_A_C,X_130145432_T_G,3_123110887_T_G,15_84241166_A_C
##brain	Gene_EXP:ICA1	1_451649_A_AG
##brain	Gene_EXP:BMPR1B	1_451649_A_AG,15_101875991_T_TC
##brain	Gene_EXP:IFI30	16_55415_T_G
##brain	Gene_EXP:RETSAT	1_113900413_C_G,10_43200831_A_G
##brain	Gene_EXP:BPTF	17_55774876_T_G
##brain	Gene_EXP:IFI35	11_12162199_T_G,16_30953637_A_C
##brain	Gene_EXP:RFC3	19_9566733_T_G
##brain	Gene_EXP:BRCA1	1_1918090_A_G
##brain	Gene_EXP:IFITM2	13_113159942_A_G
##brain	Gene_EXP:RFX7	15_65451964_A_G
##brain	Gene_EXP:BRD3	2_113934259_C_T
##brain	Gene_EXP:IFITM3	7_149253814_T_G,8_27431326_A_G,13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:RGS3	2_241744700_T_C,2_241748788_C_T,2_241748877_C_T,2_241751260_G_A
##brain	Gene_EXP:BSN	13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:BTD	9_89037986_T_G,17_55774876_T_G
##brain	Gene_EXP:IFNAR1	16_259458_T_G,1_154331414_T_G,1_64663808_A_C,18_14183954_G_T,7_32543154_A_C
##brain	Gene_EXP:RHBDF1	12_40313960_G_T
##brain	Gene_EXP:BTN3A3	13_113159942_A_G,19_9566733_T_G
##brain	Gene_EXP:RHOC	1_149852603_A_G,5_181155466_T_G,13_113159942_A_G,17_55774876_T_G
##brain	Gene_EXP:IFNAR1	16_259458_T_G,1_154331414_T_G,1_64663808_A_C,19_7740447_T_G,15_84241166_A_C
##brain	Gene_EXP:C11orf24	4_74038466_A_C,17_18282776_T_G,17_46038577_T_G
##brain	Gene_EXP:C12orf10	10_73803641_A_G
##brain	Gene_EXP:RHOG	5_427675_T_C,13_113159942_A_G,16_30398066_C_A,22_17727059_T_G,16_1817242_T_C
##brain	Gene_EXP:IGF2R	1_149852603_A_G
##brain	Gene_EXP:C12orf23	16_72119226_C_G
##brain	Gene_EXP:IGFBP6	12_51745916_T_G
##brain	Gene_EXP:C12orf29	4_173528913_A_G,10_79312556_A_G,12_40313960_G_T,15_65451964_A_G
##brain	Gene_EXP:RIC3	2_224001670_G_A,2_224001859_C_A
##brain	Gene_EXP:IGSF9	16_87644643_G_A,13_113325635_A_G,8_7290003_A_C,2_113934259_C_T,5_181155466_T_G
##brain	Gene_EXP:RIN2	2_15474280_T_C,11_65547388_T_G
##brain	Gene_EXP:C12orf44	12_16364060_G_A,8_72935904_A_T,15_79456813_C_T,12_96500996_C_A,15_40296801_A_G
##brain	Gene_EXP:RIOK3	1_1918305_G_A,2_61492168_C_A,19_4679822_A_C
##brain	Gene_EXP:IGSF9	16_87644643_G_A,5_181155466_T_G,12_6818898_A_C,13_113325635_A_G,8_7290003_A_C
##brain	Gene_EXP:RIPK1	11_65547388_T_G,16_1817242_T_C,17_55774876_T_G,15_75268724_T_G,1_234373536_T_G
##brain	Gene_EXP:C14orf93	20_42084724_T_C
##brain	Gene_EXP:IL10RB	11_65547388_T_G
##brain	Gene_EXP:C16orf59	19_9566733_T_G
##brain	Gene_EXP:RNF111	1_237687398_C_T
##brain	Gene_EXP:ILF3	15_65451964_A_G,2_113934259_C_T,5_181155466_T_G,7_72942379_A_C,8_7290003_A_C
##brain	Gene_EXP:C16orf91	20_41357106_A_C
##brain	Gene_EXP:RNF135	6_30705792_T_G
##brain	Gene_EXP:C17orf53	2_131597280_C_G,17_6998597_A_C,19_39885857_T_G
##brain	Gene_EXP:RNF144A	14_96362953_G_A
##brain	Gene_EXP:ILF3	15_65451964_A_G,5_181155466_T_G,2_113934259_C_T,8_7290003_A_C,7_72942379_A_C
##brain	Gene_EXP:C19orf10	16_72119226_C_G,16_72129067_G_T
##brain	Gene_EXP:RNF157	10_11921140_T_G
##brain	Gene_EXP:C19orf59	19_1095353_C_G,19_1095356_C_T
##brain	Gene_EXP:ILF3	15_65451964_A_G,7_72942379_A_C,2_113934259_C_T,5_181155466_T_G,8_7290003_A_C
##brain	Gene_EXP:RNF165	10_11921140_T_G,16_1817242_T_C
##brain	Gene_EXP:C19orf66	16_87644643_G_A,X_2856636_A_C
##brain	Gene_EXP:RNF181	16_30953637_A_C
##brain	Gene_EXP:C1GALT1C1	19_7740447_T_G,19_4911043_A_C,9_126483890_T_G,1_54243266_A_G,10_73803641_A_G
##brain	Gene_EXP:IMPAD1	2_27774175_G_T
##brain	Gene_EXP:RNF216	2_230310834_T_C,2_230401046_T_C
##brain	Gene_EXP:INA	13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:RNF44	8_12430448_C_T,10_11921140_T_G
##brain	Gene_EXP:C1orf198	18_6985656_C_T
##brain	Gene_EXP:INO80D	11_12162199_T_G
##brain	Gene_EXP:RNH1	13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:C1orf74	12_40313960_G_T
##brain	Gene_EXP:INTS2	20_42084724_T_C
##brain	Gene_EXP:RNPC3	17_55774876_T_G,20_5501817_T_G
##brain	Gene_EXP:C1QTNF4	2_108507561_T_G
##brain	Gene_EXP:IPO9	12_51745916_T_G
##brain	Gene_EXP:RPAIN	9_69516199_A_C,11_18089364_C_A
##brain	Gene_EXP:C1R	13_113159942_A_G
##brain	Gene_EXP:IQGAP1	3_128945112_G_A,5_181155466_T_G,8_122952205_T_G,13_113325635_A_G,19_9566733_T_G
##brain	Gene_EXP:RPAP1	2_96842345_G_C
##brain	Gene_EXP:C1S	12_40313960_G_T
##brain	Gene_EXP:RPL13	20_42084724_T_C
##brain	Gene_EXP:C22orf32	18_79527652_GAA_G,13_113159942_A_G,7_100797615_T_G,12_6818898_A_C,16_58525116_G_T
##brain	Gene_EXP:IRF1	12_51745916_T_G,17_55774876_T_G
##brain	Gene_EXP:RPL19	2_61492168_C_A
##brain	Gene_EXP:IRF2	1_149852603_A_G,1_219979389_T_A
##brain	Gene_EXP:RPL3	2_24067801_G_A
##brain	Gene_EXP:C2orf43	7_108023984_G_A,12_109800676_G_A,19_3281403_A_C,20_42084724_T_C
##brain	Gene_EXP:IRS1	12_51745916_T_G
##brain	Gene_EXP:RPL32	8_12430448_C_T
##brain	Gene_EXP:ISL1	7_72942379_A_C,11_12162199_T_G
##brain	Gene_EXP:C2orf44	7_108023984_G_A,7_108024001_C_T,11_65547388_T_G,14_55169342_TAAA_T
##brain	Gene_EXP:RPL37	11_12162199_T_G
##brain	Gene_EXP:ITCH	1_451649_A_AG,1_13281477_A_G
##brain	Gene_EXP:RPL37A	2_216423665_G_C,2_216432695_A_G,2_216438364_T_C,2_216498874_C_T,2_216500041_G_T
##brain	Gene_EXP:ITGA11	1_156286332_T_G,2_36988742_C_T,5_145859657_A_G,11_12162199_T_G
##brain	Gene_EXP:C4orf21	4_145110084_AT_A
##brain	Gene_EXP:C4orf27	1_225257909_T_G,3_75669482_G_T
##brain	Gene_EXP:RPL9	3_165019547_G_T,11_12162199_T_G,11_65547388_T_G,16_72788732_T_G
##brain	Gene_EXP:ITGA3	5_181155466_T_G
##brain	Gene_EXP:C4orf46	1_44804312_T_G
##brain	Gene_EXP:ITGB5	1_234373536_T_G,2_154854926_A_C,11_65547388_T_G,17_55774876_T_G
##brain	Gene_EXP:RPS11	4_145127510_C_T,8_12430448_C_T,17_28613683_A_C
##brain	Gene_EXP:C6orf1	4_74038466_A_C
##brain	Gene_EXP:RPS28	15_43578884_A_G,17_18282629_T_G
##brain	Gene_EXP:CACNA1B	13_113159942_A_G,16_1817242_T_C,X_2856636_A_C
##brain	Gene_EXP:ITPR3	20_33072178_T_G
##brain	Gene_EXP:RPUSD4	15_75524142_T_C
##brain	Gene_EXP:CACNA2D2	17_76472531_A_C
##brain	Gene_EXP:JAKMIP1	6_33279455_T_G,13_113159942_A_G,16_1817242_T_C
##brain	Gene_EXP:RRAS	2_113934259_C_T,11_12162199_T_G,13_113159942_A_G,16_18379704_T_G,17_55774876_T_G
##brain	Gene_EXP:CALU	7_72942379_A_C
##brain	Gene_EXP:JAKMIP2	11_90041068_C_G
##brain	Gene_EXP:CAMKMT	3_165019547_G_T
##brain	Gene_EXP:JPH4	12_40313960_G_T
##brain	Gene_EXP:RRP7A	1_19243612_A_C
##brain	Gene_EXP:CAMKV	3_128945112_G_A,13_113159942_A_G,16_1817242_T_C,20_42084724_T_C
##brain	Gene_EXP:KANK1	11_12162199_T_G
##brain	Gene_EXP:RSBN1	13_113159942_A_G
##brain	Gene_EXP:KBTBD6	2_108507561_T_G,5_141478412_T_C,6_30705792_T_G,11_65547388_T_G,13_113159942_A_G
##brain	Gene_EXP:RSRC2	11_43920052_A_C
##brain	Gene_EXP:CAMSAP3	11_46894699_T_G
##brain	Gene_EXP:RTKN2	6_73644452_C_T
##brain	Gene_EXP:CAP2	1_152511746_A_C,11_43920052_A_C,1_119997159_T_G,9_34254427_T_G,X_24743203_T_G
##brain	Gene_EXP:KCNC1	16_1817242_T_C,11_43920052_A_C,1_213007133_T_G,17_76472531_A_C,16_30953637_A_C
##brain	Gene_EXP:RTN1	16_30953637_A_C
##brain	Gene_EXP:CAPG	7_72942379_A_C,10_11921140_T_G,1_156286332_T_G,15_56464990_A_C,11_12162199_T_G
##brain	Gene_EXP:RTP4	11_12162199_T_G,15_82519765_A_C,19_3281403_A_C
##brain	Gene_EXP:KCNH2	5_38950065_A_T
##brain	Gene_EXP:RUFY3	11_65547388_T_G
##brain	Gene_EXP:KCNH8	2_169735166_A_C,3_100302035_G_T,7_72942379_A_C,20_62661184_C_T
##brain	Gene_EXP:CAPG	7_72942379_A_C,10_11921140_T_G,15_56464990_A_C,11_12162199_T_G,20_45938939_T_G
##brain	Gene_EXP:RUNDC3A	10_11921140_T_G,13_113159942_A_G
##brain	Gene_EXP:KCNN4	8_7290003_A_C,10_11921140_T_G,1_15381304_A_C,5_181155466_T_G,20_45938939_T_G
##brain	Gene_EXP:RUNX1	1_78629896_T_C,2_108507561_T_G,8_7290003_A_C,10_11921140_T_G
##brain	Gene_EXP:CAPZB	8_109289769_T_C
##brain	Gene_EXP:CASKIN1	10_11921140_T_G
##brain	Gene_EXP:KCNN4	8_7290003_A_C,10_11921140_T_G,5_181155466_T_G,20_45938939_T_G,1_15381304_A_C
##brain	Gene_EXP:RUNX2	11_12162199_T_G,15_75268724_T_G
##brain	Gene_EXP:CASP1	12_40313960_G_T
##brain	Gene_EXP:RUVBL1	1_247814785_G_A,1_247815694_A_G
##brain	Gene_EXP:CASP4	12_51745916_T_G
##brain	Gene_EXP:KCNN4	8_7290003_A_C,10_11921140_T_G,5_181155466_T_G,20_45938939_T_G,10_50311228_T_G
##brain	Gene_EXP:S100A10	10_11921140_T_G
##brain	Gene_EXP:CASP7	1_155709773_T_G,22_42212334_A_C
##brain	Gene_EXP:S100A13	13_113159942_A_G,16_1817242_T_C,17_36608462_A_C,X_100585180_G_T
##brain	Gene_EXP:KCNN4	8_7290003_A_C,5_181155466_T_G,20_45938939_T_G,10_11921140_T_G,10_50311228_T_G
##brain	Gene_EXP:CAV1	12_51745916_T_G,13_39724512_C_T,17_81086334_C_G
##brain	Gene_EXP:CBR3	3_128945112_G_A,22_22098988_G_T,8_7290003_A_C,8_30756677_T_G,12_6818898_A_C
##brain	Gene_EXP:S100A2	11_65547388_T_G,17_55774876_T_G
##brain	Gene_EXP:KCTD11	17_7797836_A_C,1_54243266_A_G,11_65547388_T_G,13_113159942_A_G,14_93183653_A_C
##brain	Gene_EXP:S100A6	7_72942379_A_C,7_159142364_T_G,8_7290003_A_C,8_30756677_T_G,10_11921140_T_G
##brain	Gene_EXP:CBR3	3_128945112_G_A,8_30756677_T_G,8_7290003_A_C,22_22098988_G_T,2_60761746_T_G
##brain	Gene_EXP:KDELR3	16_72119226_C_G,16_72129067_G_T,16_72164743_G_A
##brain	Gene_EXP:SAFB	8_7290003_A_C,10_11921140_T_G,13_113159942_A_G,14_55169342_TAAA_T
##brain	Gene_EXP:KDM1A	1_26774532_T_C,5_181155466_T_G,22_42212334_A_C
##brain	Gene_EXP:CBR3	3_128945112_G_A,8_7290003_A_C,8_30756677_T_G,12_6818898_A_C,2_60761746_T_G
##brain	Gene_EXP:KDM2B	5_181155466_T_G,12_6818898_A_C
##brain	Gene_EXP:SAMD9	5_181155466_T_G,8_7290003_A_C,11_12162199_T_G
##brain	Gene_EXP:CBR4	17_55774876_T_G
##brain	Gene_EXP:KDM3B	16_71745407_G_T,16_72119226_C_G,16_72129067_G_T,16_72164743_G_A
##brain	Gene_EXP:SAMD9L	5_181155466_T_G,11_12162199_T_G,19_44784158_T_G
##brain	Gene_EXP:CBX1	20_42084724_T_C
##brain	Gene_EXP:SAMM50	17_76009153_A_C
##brain	Gene_EXP:KHDRBS1	5_181155466_T_G,12_6818898_A_C
##brain	Gene_EXP:CBX2	17_80352778_T_G,7_72942379_A_C,10_73803641_A_G
##brain	Gene_EXP:SARDH	2_113934259_C_T
##brain	Gene_EXP:KHSRP	2_54968084_G_A
##brain	Gene_EXP:CBX5	2_113934259_C_T
##brain	Gene_EXP:SART3	10_11921140_T_G,11_12162199_T_G
##brain	Gene_EXP:KIAA0247	1_149852603_A_G,7_114630022_T_G,16_18379704_T_G,17_55774876_T_G,19_15191478_T_G
##brain	Gene_EXP:CCDC107	11_1242476_T_G,20_62661184_C_T,16_259458_T_G,1_171541102_T_G,1_154331414_T_G
##brain	Gene_EXP:SAT1	12_40313960_G_T
##brain	Gene_EXP:SBDS	12_104756998_T_G
##brain	Gene_EXP:KIAA1009	14_68291858_T_C
##brain	Gene_EXP:CCDC107	16_259458_T_G,1_154331414_T_G,18_14183954_G_T,17_19414393_T_G,11_1242476_T_G
##brain	Gene_EXP:SCAMP5	X_100585180_G_T
##brain	Gene_EXP:KIAA1143	20_9407810_T_C
##brain	Gene_EXP:SCN3B	13_113159942_A_G
##brain	Gene_EXP:CCDC112	11_65547388_T_G,17_55774876_T_G
##brain	Gene_EXP:KIAA1549	15_40855887_C_T,15_40855965_C_T,17_75834935_G_A
##brain	Gene_EXP:SDAD1	2_190437403_T_G,14_96331387_G_A,15_82525003_A_C
##brain	Gene_EXP:CCDC138	8_30756677_T_G,12_40313960_G_T,15_75524142_T_C
##brain	Gene_EXP:KIDINS220	1_113549504_C_T,2_113934259_C_T
##brain	Gene_EXP:SDC4	12_40313960_G_T,13_113159942_A_G
##brain	Gene_EXP:CCDC41	9_86322936_ATTT_A,9_86345023_C_T
##brain	Gene_EXP:KIF13A	10_79312556_A_G
##brain	Gene_EXP:SDCCAG3	2_232406987_T_TACAC
##brain	Gene_EXP:CCDC77	7_108023984_G_A
##brain	Gene_EXP:KIF1A	9_69516199_A_C
##brain	Gene_EXP:SEC24A	7_5308283_G_A,15_28382572_T_C
##brain	Gene_EXP:CCDC80	10_50311228_T_G,16_72119226_C_G,16_72129067_G_T
##brain	Gene_EXP:KIF1C	9_93293047_T_G,13_113159942_A_G,16_1817242_T_C,19_43359207_C_A
##brain	Gene_EXP:SEC61A1	9_37887606_C_T
##brain	Gene_EXP:CCNB1IP1	17_55774876_T_G
##brain	Gene_EXP:SELRC1	12_40313960_G_T
##brain	Gene_EXP:KIF21A	7_108023984_G_A
##brain	Gene_EXP:CCNF	19_9566733_T_G
##brain	Gene_EXP:SEMA4D	11_125626705_T_G
##brain	Gene_EXP:KIF22	5_80744593_A_C,19_9566733_T_G
##brain	Gene_EXP:CCNJ	1_234373536_T_G,14_55169342_TAAA_T
##brain	Gene_EXP:SEMA4G	6_146733274_T_TA
##brain	Gene_EXP:KIF26A	7_159142364_T_G,10_11921140_T_G
##brain	Gene_EXP:CCNT1	1_197912561_T_G,5_115984518_A_T,8_98032165_T_G,15_65451964_A_G
##brain	Gene_EXP:SEPHS1	2_113934259_C_T
##brain	Gene_EXP:KIF5A	1_20724406_A_C,11_12162199_T_G,16_1817242_T_C
##brain	Gene_EXP:CCT2	12_40313960_G_T
##brain	Gene_EXP:SEPW1	2_61492168_C_A
##brain	Gene_EXP:KLC1	6_30705792_T_G,9_35801627_T_G
##brain	Gene_EXP:CCT3	1_16589114_C_T,1_146969331_G_A
##brain	Gene_EXP:SERINC3	2_105307612_A_C
##brain	Gene_EXP:KLF15	8_7259511_T_C,10_50311228_T_G
##brain	Gene_EXP:CCT4	7_108023984_G_A
##brain	Gene_EXP:SERPINB6	2_227062473_GT_G
##brain	Gene_EXP:KLF6	12_95474188_T_G
##brain	Gene_EXP:CCT7	12_40313960_G_T
##brain	Gene_EXP:SERPINB8	17_55774876_T_G
##brain	Gene_EXP:KLHL23	10_79312556_A_G,13_113159942_A_G,13_113325635_A_G
##brain	Gene_EXP:CCT8	7_108023984_G_A,7_108024001_C_T,8_61583890_T_A
##brain	Gene_EXP:SERPINE1	5_181155466_T_G,6_30705792_T_G,11_65547388_T_G,12_51745916_T_G,17_55774876_T_G
##brain	Gene_EXP:KLHL3	3_10062127_TA_T
##brain	Gene_EXP:CD109	10_11921140_T_G
##brain	Gene_EXP:SERPINE2	7_72942379_A_C
##brain	Gene_EXP:KLHL36	13_113159942_A_G
##brain	Gene_EXP:CD151	1_54243266_A_G,11_12162199_T_G,1_234373536_T_G,6_158785582_A_C,15_84241166_A_C
##brain	Gene_EXP:SERPING1	9_108900415_C_A,17_41725799_T_G
##brain	Gene_EXP:KLHL8	1_150261398_T_G,13_113159942_A_G,6_56557393_C_T,15_84241166_A_C,5_181155466_T_G
##brain	Gene_EXP:CD151	1_54243266_A_G,15_84241166_A_C,5_38950065_A_T,6_158785582_A_C,11_12162199_T_G
##brain	Gene_EXP:SESN1	8_93815432_A_C
##brain	Gene_EXP:LAMB2	12_40313960_G_T,17_7797836_A_C,19_1356451_T_G

[표 6]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value)를 산출한 결과가 아래 [표 7]에 정리되어있다.

또한, [표 6]에 제시된 FRH들이 포함되어 발현된 유전자들 증 주요 유전자와 각각의 brain(뇌종양) 약물과의 상관도(P-value)를 산출한 결과가 아래 도 27에 정리되어있다.

Correlation between gene expression and FRH

Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)
PTRF	2.02E-17	GNS	1.98E-10	KANK1	5.23E-09
MALT1	6.80E-17	SSBP3	2.01E-10	SPOCD1	5.27E-09
FAM117B	3.28E-16	TRMT61B	2.04E-10	FLNB	5.28E-09
OLFML2A	3.28E-16	VIM	2.07E-10	MFSD12	5.30E-09
CBX2	3.46E-16	FAM127A	2.10E-10	MOAP1	5.34E-09
ANXA1	5.90E-16	GPX8	2.11E-10	VPS72	5.37E-09
N4BP2	7.92E-16	HNRNPC	2.13E-10	IL10RB	5.43E-09
TNFRSF12A	8.20E-16	RPS29	2.13E-10	PAK7	5.43E-09
MYOF	2.02E-15	LRBA	2.17E-10	SNRNP200	5.45E-09
FAM129B	2.35E-15	LRIG1	2.18E-10	CD82	5.56E-09
ILF3	2.88E-15	ECSIT	2.19E-10	GLT25D1	5.64E-09
KLHL8	5.57E-15	NARS2	2.23E-10	ZNF704	5.68E-09
BHLHE40	5.57E-15	SAFB	2.24E-10	ARNTL2	5.71E-09
KCNN4	6.83E-15	MVP	2.27E-10	BCL9L	5.75E-09
EXT2	7.61E-15	ACTN2	2.27E-10	SLC39A13	5.77E-09
ITGA3	8.85E-15	P4HA1	2.28E-10	HNRNPA0	5.82E-09
GUF1	1.00E-14	ANP32A	2.28E-10	EIF2AK4	5.83E-09
GBE1	1.32E-14	CXXC4	2.33E-10	MYRIP	5.90E-09
HLA-B	1.35E-14	HLA-A	2.34E-10	DLK1	5.91E-09
ANXA2	1.43E-14	GATA2	2.38E-10	ACN9	5.97E-09
CD151	1.47E-14	SERPINB6	2.41E-10	MPST	5.98E-09
ACVR1B	1.51E-14	EPS8	2.42E-10	DDX20	5.99E-09
GADD45B	1.61E-14	MMD	2.48E-10	FTH1	6.02E-09
MYO1E	1.94E-14	FOSL2	2.48E-10	TNC	6.05E-09
WDR12	2.10E-14	KLF2	2.54E-10	NUP133	6.15E-09
KCNH8	2.12E-14	DAG1	2.60E-10	HNRNPA3	6.20E-09
ACTN4	2.19E-14	SRRM4	2.65E-10	ZNF572	6.20E-09
FLNA	2.48E-14	ZNF516	2.66E-10	TMEM33	6.27E-09
KCTD11	2.55E-14	CLIC1	2.67E-10	LRFN2	6.31E-09
NIPSNAP1	2.59E-14	TSEN54	2.75E-10	DDX55	6.31E-09
ADAM9	2.60E-14	RAB3C	2.78E-10	SPAST	6.45E-09
TAP1	2.95E-14	SPPL2A	2.81E-10	ADCYAP1R1	6.47E-09
PEA15	3.09E-14	GALNT10	2.82E-10	YTHDC1	6.49E-09
CREB3	3.12E-14	ZNF507	2.84E-10	GRIA4	6.52E-09
PLP2	3.80E-14	DOC2A	2.86E-10	TSSC1	6.58E-09
THBS1	3.98E-14	SPAG1	2.90E-10	PFKL	6.68E-09
DNMT3A	4.00E-14	DCBLD1	2.90E-10	UBE2H	6.73E-09
LAMP1	4.16E-14	PRDM1	2.92E-10	CKAP4	6.75E-09
LDHB	4.67E-14	TMEM145	2.95E-10	AKR7A2	6.77E-09
LAMB2	5.94E-14	SULT4A1	2.99E-10	UBE2N	6.77E-09
GTF3C3	6.40E-14	CCDC109B	3.01E-10	FASTKD1	6.82E-09
TRAM2	6.41E-14	TNFRSF1A	3.04E-10	TMEM151B	6.84E-09
PAX6	6.65E-14	SDC4	3.06E-10	NEU1	6.91E-09
CRIM1	7.47E-14	FAM120A	3.11E-10	UNC5B	6.97E-09
IFNAR1	7.80E-14	NAGK	3.19E-10	CLASP1	6.98E-09
ISL1	8.68E-14	CPD	3.25E-10	DLX6	7.14E-09
PRMT1	9.24E-14	RHOU	3.27E-10	PIEZO1	7.24E-09
FLII	9.70E-14	SCG3	3.28E-10	STXBP4	7.31E-09
SLC10A3	1.02E-13	COPS7B	3.33E-10	SLC16A4	7.31E-09
LIN28B	1.05E-13	KDM1A	3.33E-10	HNRNPH3	7.32E-09
FOSL1	1.23E-13	IGFBP6	3.43E-10	F3	7.33E-09
C1GALT1C1	1.38E-13	ELAVL3	3.44E-10	PAPOLG	7.34E-09
S100A6	1.43E-13	TUBA1C	3.47E-10	GNPAT	7.40E-09
KHDRBS1	1.47E-13	PION	3.49E-10	CTCF	7.59E-09
PRSS23	1.62E-13	HADHA	3.50E-10	CBX5	7.59E-09
DCBLD2	1.65E-13	STARD7	3.55E-10	TARS2	7.63E-09
B2M	1.89E-13	HSPG2	3.57E-10	SOX11	7.69E-09
UBE2A	2.16E-13	SLC16A2	3.57E-10	MAN2B2	7.70E-09
PATZ1	2.28E-13	WNK2	3.58E-10	NAA25	7.75E-09
ACTN1	2.81E-13	DTX3L	3.61E-10	MRPL48	7.78E-09
RAB27A	4.12E-13	DKK3	3.69E-10	TNFAIP3	7.80E-09
TACC1	4.16E-13	UBA7	3.73E-10	C11orf74	7.84E-09
RARRES3	4.25E-13	SLC22A23	3.79E-10	MRPL21	7.84E-09
ZNF74	4.34E-13	GPHN	3.80E-10	PNN	7.92E-09
MGAT4B	4.73E-13	PDE1C	3.85E-10	TBKBP1	7.94E-09
CD99	4.85E-13	MTPAP	3.87E-10	SQLE	8.00E-09
BMP1	4.95E-13	MOSPD2	3.87E-10	LCLAT1	8.07E-09
BEND4	5.02E-13	SYPL1	3.90E-10	FBL	8.11E-09
HIC2	5.07E-13	EPB41	3.98E-10	SMAD9	8.13E-09
PRICKLE2	5.29E-13	P4HA2	4.01E-10	LSM7	8.13E-09
ZBTB4	5.34E-13	NT5E	4.05E-10	PDE3B	8.14E-09
TPMT	6.11E-13	CFLAR	4.07E-10	PLS3	8.14E-09
MYLK	6.85E-13	EHD2	4.10E-10	TUFM	8.15E-09
MARCKSL1	7.18E-13	CCT3	4.11E-10	DNAJC12	8.25E-09
HEXB	7.48E-13	EFEMP1	4.17E-10	PHF21A	8.42E-09
PLEC	7.49E-13	HSPD1	4.19E-10	PARP9	8.43E-09
RIPK1	8.47E-13	CHD7	4.20E-10	CD109	8.44E-09
RPL3	9.02E-13	CMPK1	4.22E-10	LDLRAD3	8.60E-09
TRAP1	9.16E-13	COL4A1	4.29E-10	MYCN	8.62E-09
ATXN7L3B	9.25E-13	PHF21B	4.29E-10	GALNT5	8.65E-09
SMPD1	9.44E-13	CSRP1	4.36E-10	DPY30	8.68E-09
SERPINE1	9.54E-13	RPL38	4.37E-10	RNF144A	8.72E-09
TMED9	9.82E-13	CYR61	4.40E-10	PCYT1A	8.76E-09
CCDC88C	1.00E-12	TRIM22	4.44E-10	ATL2	8.80E-09
GPC1	1.04E-12	TRIP6	4.45E-10	FGFBP3	8.84E-09
AXL	1.06E-12	HNRPDL	4.47E-10	OCIAD1	8.89E-09
MICALL2	1.07E-12	LHFP	4.58E-10	LRRC16B	9.05E-09
LRRC8B	1.08E-12	MYL12B	4.70E-10	EPSTI1	9.15E-09
GLIPR1	1.19E-12	GRPEL2	4.72E-10	STOX2	9.24E-09
FKBP15	1.21E-12	RPL31	4.82E-10	PDE2A	9.25E-09
ATCAY	1.26E-12	SLC39A7	4.96E-10	C1R	9.31E-09
LOXL2	1.28E-12	FXYD5	5.01E-10	POLR2B	9.36E-09
DDX25	1.35E-12	SERPINB8	5.05E-10	SRSF2	9.43E-09
STK17A	1.38E-12	SYTL2	5.06E-10	AGTPBP1	9.43E-09
CCDC107	1.41E-12	TEX15	5.17E-10	KIF13A	9.46E-09
TGOLN2	1.43E-12	INA	5.20E-10	FAM57B	9.46E-09
ACOT9	1.47E-12	COG2	5.28E-10	CELF3	9.49E-09
SQSTM1	1.51E-12	CCNT1	5.37E-10	PRPF40A	9.64E-09
VASH2	1.51E-12	PLOD2	5.40E-10	NEFH	9.77E-09
EHD4	1.53E-12	CHST7	5.44E-10	CABYR	9.84E-09
EIF3L	1.56E-12	PDCD1LG2	5.53E-10	CIAPIN1	9.84E-09
SORCS1	1.64E-12	NDP	5.57E-10	AHNAK2	9.95E-09
SPARC	1.66E-12	PXN	5.57E-10	MTX2	1.01E-08
HRCT1	1.66E-12	ZSCAN2	5.63E-10	C12orf29	1.01E-08
SNRPF	1.86E-12	FAM114A1	5.63E-10	SLC7A2	1.02E-08
MYBL1	1.95E-12	CNTFR	5.64E-10	LRRFIP2	1.02E-08
CCNB1IP1	2.01E-12	TCF20	5.96E-10	PAICS	1.02E-08
CD99L2	2.02E-12	BRD3	5.97E-10	GABRB3	1.04E-08
TAPBP	2.07E-12	UBE2O	6.08E-10	TCERG1	1.05E-08
SAT1	2.14E-12	IFITM3	6.19E-10	COL6A2	1.05E-08
RNF44	2.20E-12	SMARCA5	6.21E-10	TAF5	1.05E-08
ESYT2	2.24E-12	CERCAM	6.35E-10	PDE7A	1.06E-08
KIF1C	2.24E-12	CASP1	6.37E-10	ATL3	1.07E-08
FAM20C	2.29E-12	ELAVL4	6.40E-10	CAMSAP1	1.07E-08
ELL2	2.32E-12	DNAAF2	6.41E-10	FSD1	1.07E-08
NCEH1	2.45E-12	ACTL6B	6.42E-10	TMCO4	1.07E-08
PLAUR	2.57E-12	RAB32	6.42E-10	TSPAN7	1.08E-08
NQO2	2.73E-12	GBA	6.58E-10	GPX1	1.08E-08
C14orf93	2.78E-12	EIF3H	6.59E-10	ARC	1.08E-08
MTF2	2.83E-12	PHB2	6.65E-10	FKBP5	1.08E-08
PPIC	2.93E-12	SH2D3C	6.80E-10	ABAT	1.09E-08
CD70	2.95E-12	C1orf43	6.81E-10	EIF4ENIF1	1.11E-08
S100A16	2.96E-12	H3F3B	7.08E-10	FAU	1.11E-08
TFAP4	3.03E-12	C16orf88	7.12E-10	HSPA5	1.12E-08
HIST1H3F	3.03E-12	BAI3	7.32E-10	DOK4	1.14E-08
NOL11	3.05E-12	TMEM184B	7.35E-10	B3GNT9	1.14E-08
NSL1	3.10E-12	ZNF711	7.36E-10	TOR1B	1.14E-08
SUMF1	3.21E-12	GRASP	7.40E-10	CELF1	1.15E-08
PXDC1	3.25E-12	GAS6	7.51E-10	FAM89A	1.15E-08
GTF3C2	3.37E-12	HFM1	7.61E-10	RBM12B	1.17E-08
LIMD2	3.50E-12	KCNH2	7.78E-10	P4HB	1.17E-08
GSN	3.51E-12	XPO5	7.84E-10	ENO3	1.18E-08
GNAI2	3.55E-12	TAX1BP3	7.91E-10	ZNF638	1.18E-08
SMARCA4	3.60E-12	CLCN5	7.93E-10	AGBL5	1.19E-08
WHAMM	3.60E-12	PRR5L	7.99E-10	NAALAD2	1.19E-08
DRAM1	3.85E-12	CHPF	8.03E-10	GTPBP3	1.22E-08
CAST	3.86E-12	C9orf72	8.10E-10	ARSJ	1.23E-08
ARID2	4.07E-12	PDZD11	8.10E-10	NDEL1	1.24E-08
HLA-E	4.10E-12	FAM161A	8.16E-10	SEMA6A	1.28E-08
CAPN2	4.10E-12	SNRNP35	8.31E-10	KDM2B	1.28E-08
GLIS3	4.34E-12	IL13RA1	8.58E-10	ARNTL	1.29E-08
MAP4	4.38E-12	BCL2	8.60E-10	CCNJ	1.29E-08
BCL6	4.47E-12	FBXO32	8.62E-10	DPYD	1.29E-08
NLRC5	4.74E-12	CNTNAP2	8.68E-10	XRCC5	1.31E-08
SLC46A3	4.78E-12	LMAN2	8.68E-10	NTRK1	1.31E-08
TRIM56	4.85E-12	RIPPLY2	8.71E-10	EML5	1.32E-08
ATP5B	4.92E-12	BEND3	8.78E-10	DUSP12	1.32E-08
RHOC	4.93E-12	ITGAV	8.81E-10	HSP90AB1	1.33E-08
MAN1B1	5.08E-12	LIAS	8.81E-10	MDM4	1.34E-08
ABCC3	5.12E-12	PDGFA	9.01E-10	EWSR1	1.35E-08
GBP1	5.17E-12	EMP3	9.07E-10	SLC26A10	1.37E-08
CEP44	5.31E-12	WWTR1	9.10E-10	HDGF	1.39E-08
COTL1	5.37E-12	HTRA1	9.20E-10	MRPS25	1.39E-08
HEG1	5.75E-12	MPHOSPH10	9.33E-10	EMP1	1.40E-08
CCDC138	5.75E-12	CAP2	9.35E-10	QSOX1	1.40E-08
CSRNP3	5.76E-12	SH3BGRL	9.41E-10	TFAP2A	1.42E-08
GINM1	5.87E-12	TSPAN4	9.48E-10	NRXN2	1.43E-08
CD44	6.04E-12	RSRC2	9.72E-10	ATOH7	1.46E-08
PDSS1	6.17E-12	APOL2	9.77E-10	TRMT1	1.47E-08
TWSG1	6.41E-12	SFSWAP	9.82E-10	SLC26A6	1.48E-08
CST3	6.71E-12	DPF1	9.89E-10	STK38	1.48E-08
RAB11FIP5	6.75E-12	MRC2	1.00E-09	PHLDB2	1.48E-08
SYNJ2	6.87E-12	ITGB1	1.01E-09	CEP72	1.50E-08
PIGB	7.16E-12	CALU	1.01E-09	IFIT3	1.51E-08
PML	7.19E-12	SLC9A7	1.01E-09	PLEKHF1	1.51E-08
ACVR2B	7.23E-12	ARF4	1.02E-09	DDX21	1.52E-08
BCL7A	7.27E-12	PPAP2A	1.02E-09	RAX	1.52E-08
LY96	7.38E-12	GCNT1	1.02E-09	IER5L	1.52E-08
B4GALT1	7.40E-12	GPR125	1.03E-09	AIG1	1.53E-08
FSTL1	7.41E-12	ACADVL	1.03E-09	LACTB	1.53E-08
MAGT1	7.55E-12	EFR3A	1.04E-09	SLC2A10	1.54E-08
HNRNPA1L2	7.81E-12	DLL3	1.04E-09	UAP1	1.54E-08
GRAMD3	8.21E-12	RCOR2	1.04E-09	IRAK1BP1	1.54E-08
RPL37	8.30E-12	ITPR3	1.07E-09	LGALS1	1.55E-08
POU2F1	8.67E-12	NVL	1.08E-09	FBRSL1	1.56E-08
MID1	8.77E-12	SLC5A6	1.09E-09	LAYN	1.58E-08
TGFB1I1	8.79E-12	TMEM158	1.09E-09	MKI67IP	1.59E-08
OPTN	8.90E-12	MDN1	1.10E-09	ARID5B	1.59E-08
KLHL23	9.08E-12	YEATS4	1.16E-09	RPL30	1.59E-08
RUNX1	9.21E-12	NR3C1	1.17E-09	VPS13D	1.59E-08
DAP	9.95E-12	TREX1	1.18E-09	CHGA	1.59E-08
PARP1	1.02E-11	CHST14	1.19E-09	ATP2B4	1.59E-08
FOXN2	1.04E-11	FKBP4	1.21E-09	PRKD1	1.59E-08
PPAT	1.06E-11	HOXB3	1.21E-09	USP6NL	1.60E-08
KIF1A	1.06E-11	ITGB5	1.22E-09	S100A11	1.60E-08
DDO	1.07E-11	LUC7L3	1.22E-09	FOXG1	1.62E-08
PODXL2	1.10E-11	DLG1	1.23E-09	RAVER2	1.62E-08
CAPG	1.18E-11	DHX36	1.23E-09	MTUS1	1.63E-08
CIB1	1.20E-11	ZNF689	1.24E-09	SULT1C4	1.65E-08
ALKBH2	1.22E-11	PKM	1.26E-09	PELI1	1.66E-08
ATG4A	1.22E-11	LDLRAP1	1.26E-09	TMEM97	1.66E-08
TLN1	1.23E-11	RPRD2	1.27E-09	NFIC	1.69E-08
NUCB2	1.25E-11	C1QTNF4	1.27E-09	ZNF607	1.69E-08
CEP68	1.29E-11	PDCD4	1.28E-09	MX1	1.73E-08
PLK2	1.29E-11	ST6GAL1	1.29E-09	VASP	1.73E-08
FAM111A	1.30E-11	ZNF397	1.29E-09	METTL21A	1.73E-08
TMEM50B	1.30E-11	CCAR1	1.32E-09	RPS11	1.75E-08
RAB3A	1.31E-11	CNBP	1.32E-09	EPHA7	1.76E-08
CEP95	1.33E-11	SRPX	1.34E-09	PMS1	1.80E-08
C15orf52	1.34E-11	OSTM1	1.34E-09	CNNM4	1.80E-08
PA2G4	1.40E-11	WHSC2	1.36E-09	IFITM10	1.81E-08
S100A10	1.53E-11	GREB1	1.41E-09	RAP1GAP2	1.82E-08
SAMD9L	1.56E-11	PVR	1.43E-09	MAP2K7	1.83E-08
PTTG1IP	1.59E-11	R3HDM1	1.43E-09	GAL3ST3	1.85E-08
PFKM	1.61E-11	BAG3	1.45E-09	MESDC1	1.85E-08
TMCO3	1.61E-11	RHOA	1.45E-09	SCN3B	1.85E-08
LPP	1.65E-11	SNRPA	1.46E-09	FAM120C	1.86E-08
SMIM3	1.68E-11	RAB23	1.47E-09	SRSF12	1.86E-08
NYNRIN	1.69E-11	IPO9	1.48E-09	ZNF382	1.89E-08
TET1	1.71E-11	TAGLN2	1.49E-09	KIFC3	1.96E-08
HLA-C	1.72E-11	ERAP2	1.49E-09	KANSL2	1.99E-08
OSBPL3	1.75E-11	MRFAP1L1	1.51E-09	SDCBP	2.00E-08
CENPV	1.77E-11	NKAIN1	1.52E-09	AFMID	2.03E-08
CTSA	1.78E-11	HDAC2	1.53E-09	PPP1R13L	2.04E-08
MYH9	1.78E-11	PCGF5	1.55E-09	GPD2	2.04E-08
THAP9	1.82E-11	MATR3	1.56E-09	C19orf10	2.07E-08
PRR3	1.85E-11	CEBPZ	1.56E-09	IL1RAP	2.08E-08
ACP1	1.88E-11	TNFSF10	1.56E-09	HIST1H4C	2.09E-08
SLC6A15	1.89E-11	PRNP	1.56E-09	SHPRH	2.13E-08
MLLT10	1.96E-11	MAST1	1.59E-09	LIF	2.15E-08
MTM1	1.97E-11	CDH13	1.59E-09	TADA1	2.16E-08
RAN	2.13E-11	DDC	1.59E-09	FAM69B	2.17E-08
TMEM9B	2.16E-11	ANXA7	1.60E-09	SLC6A2	2.18E-08
MT2A	2.20E-11	HBQ1	1.61E-09	DDX58	2.18E-08
SHF	2.21E-11	SH2D4A	1.61E-09	SDF4	2.19E-08
CNN2	2.28E-11	FLVCR1	1.62E-09	GPR19	2.19E-08
IQGAP1	2.32E-11	BACE2	1.65E-09	DCP2	2.19E-08
CRAT	2.35E-11	SETDB1	1.65E-09	PRCC	2.20E-08
LATS2	2.38E-11	LMNA	1.66E-09	ASNSD1	2.22E-08
ZBTB39	2.41E-11	NRSN1	1.67E-09	LRP11	2.25E-08
DYNLT3	2.46E-11	LYST	1.69E-09	EPDR1	2.31E-08
PSMB8	2.46E-11	ARID3A	1.72E-09	HN1	2.31E-08
LRPPRC	2.48E-11	C1orf61	1.72E-09	CAMK2B	2.32E-08
MAPT	2.50E-11	EFHD2	1.73E-09	C12orf75	2.33E-08
NEXN	2.50E-11	EDIL3	1.74E-09	CLNS1A	2.33E-08
CD63	2.53E-11	RPL9	1.75E-09	SLC38A6	2.34E-08
ZNF195	2.55E-11	CDK2AP2	1.75E-09	ZNF646	2.36E-08
PSMB9	2.56E-11	UBASH3B	1.80E-09	PRPF38B	2.39E-08
NOP58	2.57E-11	MED28	1.81E-09	RSBN1	2.40E-08
TTC5	2.60E-11	RUNDC3A	1.82E-09	TMEM206	2.43E-08
REEP5	2.61E-11	PDIA2	1.82E-09	CYBASC3	2.43E-08
TIMP1	2.63E-11	DTNB	1.83E-09	MICB	2.44E-08
PINK1	2.65E-11	PHACTR3	1.83E-09	CRTAP	2.46E-08
RUNX2	2.65E-11	ILF2	1.84E-09	IRS1	2.48E-08
NNMT	2.76E-11	RSL1D1	1.85E-09	GLCCI1	2.49E-08
DHX15	2.89E-11	HMGB2	1.88E-09	VCL	2.50E-08
HRH1	2.92E-11	ATP5G2	1.90E-09	PANK1	2.50E-08
NEK6	2.94E-11	GLB1L2	1.91E-09	GSDMD	2.50E-08
NUP35	3.01E-11	SURF4	1.92E-09	ST8SIA3	2.51E-08
CCT2	3.04E-11	IRF1	1.92E-09	SGMS2	2.55E-08
COX7A2L	3.18E-11	ZC3H8	1.93E-09	ISYNA1	2.55E-08
RNF165	3.35E-11	AKIP1	1.95E-09	ATP2B3	2.55E-08
ANKRD46	3.49E-11	PLEKHM1	1.96E-09	RD3	2.57E-08
CTGF	3.51E-11	GNB5	2.03E-09	GLTPD1	2.58E-08
C22orf32	3.55E-11	CLIC4	2.06E-09	DOPEY2	2.58E-08
SAMD9	3.58E-11	BTD	2.07E-09	C5orf46	2.60E-08
SMCR7L	3.59E-11	BSN	2.08E-09	NDUFAF4	2.61E-08
CHD4	3.65E-11	VAMP5	2.09E-09	HSPE1	2.62E-08
BPTF	3.69E-11	FAM168B	2.09E-09	PQLC3	2.65E-08
APEX1	3.81E-11	WDR33	2.10E-09	GTPBP1	2.65E-08
PAM	3.91E-11	RANBP17	2.11E-09	TOM1L2	2.66E-08
AHCY	4.00E-11	CHRNA3	2.13E-09	FAP	2.68E-08
WDR1	4.08E-11	STEAP3	2.13E-09	EPT1	2.70E-08
CAV1	4.08E-11	B4GALT7	2.14E-09	TAGLN	2.70E-08
IGSF9	4.15E-11	KIF26A	2.14E-09	NSMCE4A	2.71E-08
GDPD1	4.19E-11	RNPS1	2.16E-09	SQRDL	2.72E-08
SHISA4	4.29E-11	PPIG	2.18E-09	MYB	2.74E-08
EPHA2	4.33E-11	NIPAL3	2.19E-09	MDH1	2.75E-08
CCT7	4.41E-11	FNDC3B	2.20E-09	TGFB1	2.76E-08
SRPX2	4.42E-11	PDE4DIP	2.20E-09	PSMB5	2.77E-08
SYT1	4.42E-11	MICAL2	2.20E-09	UNC80	2.78E-08
ANXA4	4.49E-11	CALD1	2.22E-09	CREB3L4	2.81E-08
SLC29A3	4.52E-11	SH3GLB1	2.25E-09	TFCP2	2.83E-08
CTSO	4.66E-11	RLTPR	2.26E-09	KCNT2	2.91E-08
ATP6V0E1	4.77E-11	SNAP23	2.28E-09	BHLHE41	2.91E-08
CBR4	4.77E-11	SNX22	2.28E-09	CHCHD6	2.95E-08
PLIN3	4.77E-11	BAZ2A	2.30E-09	SWAP70	2.97E-08
LEPREL1	4.88E-11	BCOR	2.31E-09	RPL13	2.98E-08
LAMP2	5.05E-11	ADNP	2.35E-09	RRN3	3.03E-08
PLOD1	5.07E-11	LEPRE1	2.36E-09	DAB2IP	3.05E-08
CASKIN1	5.12E-11	RPS15A	2.37E-09	TMEM107	3.06E-08
CUX2	5.14E-11	PNMA3	2.41E-09	SNRPD1	3.08E-08
CRABP1	5.28E-11	CAMKMT	2.43E-09	BIRC3	3.10E-08
SLC22A4	5.34E-11	FGFRL1	2.45E-09	SOX4	3.10E-08
ANXA5	5.44E-11	SFPQ	2.46E-09	CYLD	3.11E-08
TIGD1	5.45E-11	STMN4	2.47E-09	ABHD2	3.11E-08
CBR3	5.64E-11	PTGR1	2.53E-09	FCHO1	3.11E-08
FAM163A	5.73E-11	SUV39H2	2.53E-09	CC2D1B	3.12E-08
LGALS3	5.82E-11	SUCLG2	2.59E-09	FYCO1	3.13E-08
TOMM20	5.91E-11	NSUN6	2.61E-09	SLC29A4	3.13E-08
WASF1	6.11E-11	TOMM22	2.62E-09	ARHGAP19	3.15E-08
SLC25A43	6.19E-11	EBF3	2.65E-09	SSRP1	3.16E-08
H2AFY2	6.20E-11	TRADD	2.71E-09	TRAM1	3.20E-08
FAM126A	6.32E-11	EPHX1	2.71E-09	C1S	3.20E-08
SMARCAD1	6.33E-11	DNASE2	2.72E-09	IL6ST	3.21E-08
CACNA1B	6.38E-11	FICD	2.76E-09	CASP4	3.25E-08
RCAN1	6.71E-11	DCAF16	2.79E-09	PARP12	3.25E-08
SELRC1	6.78E-11	MYT1L	2.79E-09	RGS3	3.27E-08
C2orf44	6.81E-11	MOCS2	2.83E-09	METTL14	3.30E-08
UBA52	6.90E-11	SF3B1	2.84E-09	KHSRP	3.31E-08
RTP4	6.98E-11	MMP14	2.85E-09	PCBP3	3.31E-08
UEVLD	7.01E-11	ZNF708	2.87E-09	NEFM	3.31E-08
TLR4	7.11E-11	TBC1D8B	2.89E-09	RBM33	3.35E-08
MRPL44	7.12E-11	RHBDF1	2.90E-09	LASP1	3.40E-08
RRAS	7.27E-11	CEP170	2.90E-09	RASA3	3.42E-08
SOAT1	7.28E-11	AMMECR1L	2.93E-09	ATP11B	3.43E-08
ICA1	7.30E-11	SLC31A2	2.94E-09	BTN3A2	3.44E-08
MOXD1	7.30E-11	PPP1CC	2.95E-09	MAB21L2	3.45E-08
KLF15	7.34E-11	ATP8A1	2.96E-09	GNG4	3.45E-08
NEDD4	7.36E-11	STX4	2.98E-09	ZRANB3	3.48E-08
MBOAT7	7.54E-11	WDR86	2.99E-09	LAMC1	3.48E-08
ORC4	7.61E-11	PALLD	3.01E-09	POLB	3.49E-08
MR1	7.64E-11	COQ10B	3.07E-09	LMF2	3.49E-08
UTRN	7.74E-11	ZNF627	3.12E-09	CECR5	3.52E-08
NKX3-1	7.77E-11	FADS3	3.12E-09	MAP2K3	3.52E-08
MBTD1	8.15E-11	IFI35	3.15E-09	FBXO45	3.53E-08
STIM1	8.18E-11	TAF3	3.16E-09	AMIGO2	3.53E-08
RASL11B	8.36E-11	G6PD	3.18E-09	RAB11FIP4	3.54E-08
CAMKV	8.53E-11	FUZ	3.20E-09	MRPL10	3.58E-08
CTSB	8.63E-11	COL5A1	3.22E-09	ONECUT2	3.59E-08
TPP1	8.95E-11	ZFP36L1	3.22E-09	NLRX1	3.59E-08
OSGEPL1	9.14E-11	NDUFB9	3.24E-09	ADAM10	3.65E-08
ST6GALNAC3	9.31E-11	PHF5A	3.25E-09	MEX3B	3.65E-08
ERBB2IP	9.34E-11	DPH5	3.27E-09	HMX1	3.70E-08
ZC3H15	9.38E-11	BCAR3	3.31E-09	SH3RF2	3.70E-08
FUCA1	9.39E-11	E2F6	3.31E-09	LINC00346	3.70E-08
MYO1C	9.54E-11	CELF5	3.37E-09	NELL2	3.71E-08
F8	9.81E-11	CMTM6	3.42E-09	KDM3B	3.74E-08
ALPK2	9.87E-11	COL4A2	3.43E-09	NRARP	3.74E-08
INO80D	9.88E-11	RRBP1	3.45E-09	CSTB	3.76E-08
PTP4A3	9.93E-11	NIF3L1	3.46E-09	KATNB1	3.78E-08
PDP1	1.06E-10	UBE2T	3.48E-09	RUVBL1	3.80E-08
WWC3	1.07E-10	PTHLH	3.55E-09	SYN2	3.81E-08
GPC2	1.08E-10	ARID3B	3.59E-09	FES	3.81E-08
MSN	1.08E-10	HAND2	3.62E-09	EHMT2	3.82E-08
SNAP91	1.08E-10	ARL1	3.62E-09	PDCD11	3.85E-08
RELB	1.11E-10	SLC12A4	3.64E-09	BIRC2	3.90E-08
MAP2K1	1.11E-10	MTMR7	3.64E-09	TCIRG1	3.92E-08
STAT2	1.11E-10	SMPD3	3.65E-09	FURIN	3.94E-08
SRSF7	1.11E-10	PHF14	3.67E-09	ZNF311	3.95E-08
DDX60	1.11E-10	ERRFI1	3.69E-09	BET1L	3.97E-08
UPP1	1.12E-10	PWWP2B	3.72E-09	KBTBD6	3.98E-08
NFIX	1.15E-10	AGPAT9	3.73E-09	LTB	4.01E-08
PHOX2A	1.16E-10	WDR74	3.73E-09	NR1H2	4.02E-08
PON2	1.17E-10	ELOVL1	3.74E-09	NRXN1	4.03E-08
PHF11	1.17E-10	AHNAK	3.78E-09	CHI3L1	4.07E-08
ZBED4	1.18E-10	TCEAL3	3.78E-09	TMEM30A	4.07E-08
CYBRD1	1.18E-10	PRAME	3.78E-09	ATP5A1	4.10E-08
JPH4	1.19E-10	RNH1	3.79E-09	SETD6	4.11E-08
GLB1	1.19E-10	S100A13	3.80E-09	SERTAD1	4.11E-08
ELF4	1.19E-10	GFPT2	3.81E-09	PRRT4	4.15E-08
RPL5	1.21E-10	CRKL	3.82E-09	H1FX	4.19E-08
WBP5	1.21E-10	ZBTB37	3.83E-09	PARVA	4.29E-08
USP7	1.22E-10	INTS2	3.87E-09	JARID2	4.31E-08
NCL	1.23E-10	MGAT1	3.97E-09	ARFGAP3	4.36E-08
PARP14	1.24E-10	UNC13A	3.99E-09	EPRS	4.51E-08
LIMA1	1.25E-10	ATP8B1	4.01E-09	MXI1	4.52E-08
ZNF124	1.29E-10	DUSP26	4.01E-09	NECAP2	4.52E-08
SART3	1.32E-10	DRAP1	4.07E-09	IL6	4.55E-08
GBP3	1.33E-10	SH3BGRL3	4.07E-09	TRIM21	4.55E-08
MEIS1	1.34E-10	FBXO11	4.08E-09	COL12A1	4.55E-08
KCNC1	1.34E-10	CPXM1	4.10E-09	TMF1	4.56E-08
GNA12	1.35E-10	BTN3A3	4.15E-09	RSBN1L	4.59E-08
HEATR5B	1.36E-10	PVRL2	4.15E-09	STMN2	4.61E-08
TGFBR2	1.37E-10	COPB2	4.16E-09	GPLD1	4.61E-08
SERINC3	1.39E-10	FASN	4.16E-09	PYGL	4.66E-08
NOLC1	1.40E-10	ASCL1	4.17E-09	RSU1	4.67E-08
EIF4B	1.42E-10	ZNF146	4.18E-09	TGFB2	4.68E-08
RPS28	1.42E-10	KDELR3	4.19E-09	LRRC4B	4.69E-08
ZNF121	1.44E-10	RPS23	4.19E-09	FLAD1	4.70E-08
POLG2	1.46E-10	FAS	4.20E-09	INTS9	4.71E-08
FRS3	1.47E-10	SAMM50	4.24E-09	DGUOK	4.71E-08
GDAP1	1.48E-10	ZNF669	4.27E-09	RAB9A	4.72E-08
CCDC80	1.49E-10	ATP2A2	4.27E-09	MAP7D1	4.73E-08
ARPC5	1.49E-10	RIMBP2	4.31E-09	YIPF2	4.81E-08
TMEM2	1.50E-10	THOC5	4.31E-09	GLTSCR2	4.82E-08
MET	1.51E-10	KLHL32	4.36E-09	ISG15	4.83E-08
CELF4	1.54E-10	NINL	4.36E-09	ANKRD17	4.84E-08
HIST3H2A	1.55E-10	TBC1D14	4.38E-09	CHPF2	4.85E-08
PLAU	1.55E-10	DDX1	4.41E-09	ITCH	4.85E-08
MYL12A	1.57E-10	CYB561D2	4.43E-09	VARS	4.87E-08
S100A2	1.62E-10	LOXL1	4.43E-09	CBLN1	4.88E-08
NQO1	1.63E-10	C10orf2	4.44E-09	ITGA11	4.95E-08
TMBIM1	1.64E-10	MYL6	4.50E-09	DHPS	4.96E-08
DHX57	1.64E-10	ADCY1	4.57E-09	PLA2G16	4.97E-08
TBC1D2	1.67E-10	CUL4B	4.60E-09	CDC14A	4.98E-08
PHIP	1.67E-10	PIGT	4.62E-09	FLOT1	4.99E-08
OSMR	1.68E-10	ABHD12	4.67E-09	NOTCH2	5.00E-08
STAT3	1.69E-10	SMARCC1	4.69E-09	RPS6KL1	5.01E-08
FAM3A	1.69E-10	PLSCR4	4.71E-09	CNOT6	5.02E-08
ABI3BP	1.72E-10	SLC35F5	4.71E-09
CPSF3	1.73E-10	RAB31	4.72E-09
PRR14L	1.76E-10	ASPH	4.74E-09
SYNC	1.77E-10	COLEC11	4.74E-09
TMEM177	1.79E-10	METAP2	4.75E-09
DDX60L	1.80E-10	MRPS21	4.77E-09
CD59	1.84E-10	RSL24D1	4.79E-09
TGFBI	1.84E-10	EVL	4.86E-09
WDYHV1	1.84E-10	CDC42EP1	4.89E-09
TBC1D9B	1.85E-10	FEV	4.94E-09
SMARCB1	1.86E-10	ZNFX1	5.02E-09
RHBDL2	1.89E-10	MACF1	5.04E-09
ATIC	1.90E-10	FUS	5.06E-09
KBTBD11	1.91E-10	EML4	5.10E-09
HMOX1	1.96E-10	WDR75	5.11E-09

이들 [표 7] 및 [도 27]로부터 [표 7] 및 [도 27]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 뇌종양 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

head&neck(두경부암) 약물에 대한 반응성 바이오 마커

Cancer_Class	Gene_exp	바이오 마커 (발현조절 FRH 변이세트)
##head_neck	Gene_EXP:ALDH3A2	1_33118073_A_C,16_14764032_A_G
##head_neck	Gene_EXP:AP1M2	1_168044966_T_A,8_17562030_G_A,6_31112217_C_T,6_31138682_C_A,1_2491175_G_A
##head_neck	Gene_EXP:ATG7	7_140753336_A_T,16_84170124_G_C
##head_neck	Gene_EXP:ATP10B	3_123931600_TAA_TA,14_19303535_T_C,17_39709512_T_C
##head_neck	Gene_EXP:C16orf45	1_151848276_A_C,6_46140015_C_G,6_46161608_G_A,6_46167752_T_C,6_46168247_G_T
##head_neck	Gene_EXP:C1orf116	3_129272155_T_C
##head_neck	Gene_EXP:C1QTNF1	4_106337071_G_A
##head_neck	Gene_EXP:CACNG4	6_5771301_A_C,7_140753336_A_T,16_11174168_A_G
##head_neck	Gene_EXP:CAMSAP3	12_14460981_T_A,19_9985806_C_T,19_9986005_G_A
##head_neck	Gene_EXP:CATSPER1	7_140753336_A_T
##head_neck	Gene_EXP:CRB3	20_32983679_C_T
##head_neck	Gene_EXP:CXADR	3_47333236_T_C,14_21082261_T_G,17_63831142_T_G,18_8387094_T_G
##head_neck	Gene_EXP:CYB561	17_75618277_G_A,17_75620366_A_T
##head_neck	Gene_EXP:DENND5A	16_14764032_A_G
##head_neck	Gene_EXP:DOCK4	7_140753336_A_T,9_76227464_A_G
##head_neck	Gene_EXP:DYNC1LI1	12_56346229_GAGA_G
##head_neck	Gene_EXP:ECE1	7_100105324_G_A,7_101031028_C_T,17_49510638_C_T,20_32983679_C_T,12_50400904_T_G
##head_neck	Gene_EXP:ELK3	14_21082261_T_G
##head_neck	Gene_EXP:EMP3	16_14764032_A_G,17_75620366_A_T
##head_neck	Gene_EXP:ESRP1	20_32983679_C_T
##head_neck	Gene_EXP:FRMD4B	20_32983679_C_T
##head_neck	Gene_EXP:FXYD3	1_110407655_G_A,16_1210969_G_A,9_88647579_G_T,22_50625559_G_C,10_103724260_T_C
##head_neck	Gene_EXP:GDAP1	4_79907586_T_A
##head_neck	Gene_EXP:GJB2	1_44978366_G_A
##head_neck	Gene_EXP:GJB3	6_129475475_C_T,17_7461905_T_G,20_32983679_C_T
##head_neck	Gene_EXP:GJB5	6_129475475_C_T,16_16349121_A_G,20_32983679_C_T
##head_neck	Gene_EXP:GJB6	1_44978366_G_A
##head_neck	Gene_EXP:GNB3	X_135719129_C_T
##head_neck	Gene_EXP:GRHL2	20_32983679_C_T
##head_neck	Gene_EXP:GYLTL1B	7_5938011_C_CCA,7_5945090_C_T
##head_neck	Gene_EXP:HOXA1	11_3410400_C_T
##head_neck	Gene_EXP:HR	2_87128802_G_A
##head_neck	Gene_EXP:IGSF9	11_27340812_T_G,14_21082261_T_G,19_12690012_T_G
##head_neck	Gene_EXP:INPP4B	7_6165368_A_C,19_54631001_T_C
##head_neck	Gene_EXP:IRX2	1_2562891_G_A,7_140753336_A_T,12_14460981_T_A
##head_neck	Gene_EXP:ITGB4	9_88647579_G_T,20_32983679_C_T
##head_neck	Gene_EXP:JAG2	1_1971961_T_G,7_48043449_T_G
##head_neck	Gene_EXP:KIFC3	1_207545558_G_A,1_207564114_G_A
##head_neck	Gene_EXP:KLC3	20_32983679_C_T
##head_neck	Gene_EXP:KRT6A	22_50576781_G_C
##head_neck	Gene_EXP:LAD1	11_118555347_C_A
##head_neck	Gene_EXP:LEPRE1	20_32983679_C_T
##head_neck	Gene_EXP:MICAL2	12_88053784_G_C,12_88054289_A_AT,12_88077197_T_G
##head_neck	Gene_EXP:NEBL	7_72926354_C_T
##head_neck	Gene_EXP:NOTCH2	20_63940084_T_G
##head_neck	Gene_EXP:OVOL1	15_22608045_C_A
##head_neck	Gene_EXP:PANK3	8_8786072_C_G,8_8797513_C_T
##head_neck	Gene_EXP:PBX3	5_19503134_C_A,9_17273880_A_G,9_33062185_G_GA
##head_neck	Gene_EXP:PDE4DIP	10_101003795_A_C
##head_neck	Gene_EXP:PEX13	10_98209718_A_C,10_98236016_C_T,10_98253681_C_T
##head_neck	Gene_EXP:PHC2	20_32983679_C_T
##head_neck	Gene_EXP:PLAU	9_114307582_T_G,16_2519752_T_C
##head_neck	Gene_EXP:PNPLA6	11_122808020_A_G,14_92651884_C_T,16_14764032_A_G
##head_neck	Gene_EXP:PPP1R14C	7_64336444_AT_A
##head_neck	Gene_EXP:PTAFR	9_132827103_T_C
##head_neck	Gene_EXP:PTX3	7_140753336_A_T,14_21082261_T_G
##head_neck	Gene_EXP:RASA3	1_159858338_A_G,9_89037499_A_T,9_138176986_A_G,13_49892902_CT_C,13_49892908_G_C
##head_neck	Gene_EXP:RASEF	2_11596179_G_A,2_131600094_A_G
##head_neck	Gene_EXP:RHOV	1_1971961_T_G
##head_neck	Gene_EXP:SEMA6A	9_129858179_C_A,9_129868385_TGAC_T,9_129873665_C_G
##head_neck	Gene_EXP:SERPINB5	22_50625559_G_C
##head_neck	Gene_EXP:SGCB	8_105802428_G_C,12_50109486_C_T
##head_neck	Gene_EXP:SGTB	10_98209718_A_C,10_98236016_C_T,10_98253681_C_T
##head_neck	Gene_EXP:SH2B3	14_21082261_T_G
##head_neck	Gene_EXP:SH2D3A	6_129475475_C_T
##head_neck	Gene_EXP:SLC39A13	7_140753336_A_T,14_21082261_T_G,3_48790461_T_G,17_35259011_T_G,20_36752827_T_G
##head_neck	Gene_EXP:SLC9A3R1	15_75783322_C_G
##head_neck	Gene_EXP:SLFN11	12_31697349_T_C
##head_neck	Gene_EXP:TLN1	6_24595848_C_G
##head_neck	Gene_EXP:TP63	20_32983679_C_T
##head_neck	Gene_EXP:TPCN1	1_240245489_G_A
##head_neck	Gene_EXP:TRIM29	11_45181661_C_T,20_32983679_C_T
##head_neck	Gene_EXP:VANGL2	6_13182486_T_G
##head_neck	Gene_EXP:VIM	16_14764032_A_G
##head_neck	Gene_EXP:WNT10A	6_129475475_C_T
##head_neck	Gene_EXP:ZHX3	7_72926354_C_T
##head_neck	Gene_EXP:ZNF546	14_23360749_G_A,14_65267030_C_T,14_92651884_C_T

[표 8]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value)를 산출한 결과가 아래 [표 9]에 정리되어있다.

또한, [표 8]에 제시된 FRH들이 포함되어 발현된 유전자와 각각의 head_neck(두경부암) 약물과의 상관도(P-value)를 산출한 결과가 아래 [도 28]에 정리되어있다.

Correlation between gene expression and FRH

Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)
FGF5	1.03E-08	KIAA0895	6.06E-06	CREG2	2.30E-05
SLC39A13	1.17E-08	BMP7	6.40E-06	DAP	2.47E-05
SH2B3	2.76E-08	LOXL2	6.56E-06	G0S2	2.48E-05
PTX3	6.76E-08	UROD	6.60E-06	PAK6	2.53E-05
RAI14	1.50E-07	CXorf57	6.66E-06	AP1S2	2.53E-05
RCN3	1.90E-07	SYT17	7.19E-06	ANKRD65	2.55E-05
SH3KBP1	1.97E-07	ZNF259	7.21E-06	ANK3	2.71E-05
RUSC2	1.99E-07	RNPEP	7.27E-06	FUT1	2.77E-05
LPXN	2.39E-07	MTUS1	7.28E-06	APOA1BP	2.77E-05
CXADR	3.19E-07	CHRNA1	7.45E-06	SMURF2	2.86E-05
MICAL2	4.02E-07	HSPA2	7.78E-06	TIMP1	2.87E-05
ANTXR2	4.24E-07	CTSL2	8.05E-06	SERPINB6	2.91E-05
LRRC1	4.81E-07	RFTN1	8.09E-06	GGCT	2.92E-05
IGSF9	5.81E-07	DRAP1	8.41E-06	TSSC4	2.93E-05
CALU	6.01E-07	CD151	8.72E-06	PLK3	3.04E-05
BET1L	7.18E-07	SLC27A3	8.89E-06	DLX4	3.10E-05
ETS1	8.17E-07	C11orf68	9.21E-06	CD44	3.13E-05
FGFR3	8.74E-07	CWH43	9.57E-06	RAB34	3.21E-05
PLEKHG6	9.17E-07	GSTP1	9.98E-06	FOSL1	3.23E-05
SLC9A3R1	9.64E-07	CPT2	1.00E-05	ZBTB47	3.23E-05
NOTCH3	9.67E-07	TGFB1I1	1.01E-05	COL6A2	3.32E-05
HYAL1	9.86E-07	RHOG	1.02E-05	PARVA	3.35E-05
TLN1	9.90E-07	KLK6	1.04E-05	KLK8	3.37E-05
TMEM200A	1.00E-06	PURB	1.06E-05	PDCD1LG2	3.40E-05
GRTP1	1.01E-06	ZNF214	1.07E-05	SEPX1	3.43E-05
TARBP1	1.04E-06	SPRTN	1.07E-05	EMP2	3.44E-05
ELK3	1.10E-06	PLEKHA1	1.08E-05	ARCN1	3.44E-05
ZNF69	1.12E-06	PPIP5K1	1.08E-05	S100A14	3.45E-05
PKIG	1.18E-06	RAB25	1.08E-05	DSC2	3.57E-05
HEMK1	1.19E-06	CASP7	1.10E-05	AFAP1	3.59E-05
FAM167A	1.26E-06	INADL	1.12E-05	SRPR	3.66E-05
C1orf210	1.28E-06	ACTR8	1.13E-05	VEPH1	3.80E-05
SYK	1.35E-06	DLX6	1.17E-05	ITGB4	3.80E-05
SYBU	1.47E-06	AFTPH	1.18E-05	ELF1	3.83E-05
KLHL13	1.51E-06	ZEB1	1.20E-05	GBE1	3.85E-05
FHL1	1.52E-06	ST6GALNAC2	1.21E-05	LINGO2	3.88E-05
VIM	1.61E-06	ADSSL1	1.21E-05	SP3	3.91E-05
LLGL2	1.67E-06	FLI1	1.25E-05	SEMA7A	3.91E-05
ABCA7	2.55E-06	PTPN4	1.25E-05	PRDM8	3.94E-05
NEURL1B	2.58E-06	AZI2	1.26E-05	ABL1	3.95E-05
VAV3	2.66E-06	ALG6	1.29E-05	KRTCAP3	4.03E-05
EIF4EBP2	2.82E-06	SLC9A7	1.33E-05	PTPRG	4.10E-05
MAGED1	2.91E-06	SLC25A37	1.38E-05	XPR1	4.16E-05
AP1M1	3.00E-06	SEPP1	1.40E-05	HHIP	4.18E-05
FGFR2	3.02E-06	ACOX1	1.44E-05	CNIH3	4.19E-05
TSPAN4	3.05E-06	RGMB	1.50E-05	FAM114A1	4.19E-05
BLNK	3.07E-06	AUTS2	1.52E-05	ARF4	4.23E-05
ZNRF2	3.27E-06	HMGA1	1.55E-05	SPINT1	4.31E-05
CNRIP1	3.31E-06	APBB1IP	1.62E-05	TRIM29	4.32E-05
KIF26A	3.40E-06	HOXC13	1.64E-05	LOX	4.35E-05
HADH	3.42E-06	RIC8A	1.67E-05	BTG2	4.36E-05
ZNF652	3.45E-06	ANXA6	1.68E-05	GNG11	4.43E-05
JAG2	3.51E-06	C6orf1	1.74E-05	RSBN1L	4.61E-05
CREB3L2	3.58E-06	LCORL	1.95E-05	TPM4	4.70E-05
ASCL2	3.85E-06	ZEB2	1.96E-05	DLC1	4.73E-05
DNAJB5	3.87E-06	RABGAP1	2.02E-05	CD9	4.89E-05
ASB1	3.88E-06	NDRG2	2.09E-05	ROGDI	4.95E-05
PYGB	4.28E-06	EFNA1	2.09E-05	PLAUR	4.96E-05
AXL	4.31E-06	C1orf35	2.09E-05	STOX2	4.97E-05
TRHDE	4.60E-06	RAP1GAP	2.10E-05	PTPN6	5.15E-05
KIAA1598	4.60E-06	LIX1L	2.10E-05	DCBLD2	5.21E-05
HR	4.72E-06	KRT74	2.10E-05	PHLDA1	5.30E-05
NAV3	4.86E-06	GPX2	2.11E-05	PIK3C2B	5.47E-05
SYNE2	5.13E-06	SUDS3	2.13E-05	EIF4A3	5.61E-05
AOX1	5.30E-06	MARK1	2.21E-05	RAPGEFL1	5.61E-05
METTL7A	5.42E-06	RIT1	2.22E-05	WDR46	5.62E-05
CLIC4	5.56E-06	PTCH1	2.23E-05

이들 [표 9] 및 [도 28]로부터 [표 9] 및 [도 28]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 두경부암 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

lung(폐암) 약물에 대한 반응성 바이오 마커

Cancer_Class	Gene_exp	바이오 마커 (발현조절 FRH 변이세트)
##lung	Gene_EXP:RAD1	3_125538667_A_G,22_26499019_C_T
##lung	Gene_EXP:P2RY2	2_112913828_T_C
##lung	Gene_EXP:AMN	12_52057489_T_C
##lung	Gene_EXP:SPAG1	3_151328520_G_A,17_50192542_A_G
##lung	Gene_EXP:TUBE1	14_68909906_G_A,14_68910058_T_C,14_68910093_G_A
##lung	Gene_EXP:SERPINF1	5_5209097_G_A
##lung	Gene_EXP:VAT1L	1_201899905_G_C
##lung	Gene_EXP:PPP1R14A	5_76209739_T_G,11_6623955_G_C,1_35479062_T_G,X_149774713_G_C,15_57438247_A_C
##lung	Gene_EXP:SEPT9	20_1915109_T_G
##lung	Gene_EXP:ATOH7	2_117944188_C_T
##lung	Gene_EXP:PEA15	19_2097371_G_C
##lung	Gene_EXP:MCM7	14_22884857_G_C
##lung	Gene_EXP:EMC3	1_197039467_A_C
##lung	Gene_EXP:TSG101	4_99524606_GCTAT_G
##lung	Gene_EXP:OR13H1	2_201723527_C_T,2_201728736_A_G
##lung	Gene_EXP:HCFC1R1	11_72017862_AGTCAAC_A,11_72023165_T_C,13_33836394_C_T,20_1477514_A_G
##lung	Gene_EXP:HCFC1R1	11_72017862_AGTCAAC_A,11_72023165_T_C,13_33836394_C_T,20_1477514_A_G
##lung	Gene_EXP:NCAPG2	1_149021276_A_C
##lung	Gene_EXP:HCFC1R1	11_72017862_AGTCAAC_A,11_72023165_T_C,13_33836394_C_T,20_1477514_A_G
##lung	Gene_EXP:CDH2	1_155060858_G_A
##lung	Gene_EXP:TOR1AIP1	19_12163145_T_G
##lung	Gene_EXP:ABCA5	17_50677651_A_G,17_78529677_G_C
##lung	Gene_EXP:TP53I11	7_45648634_G_A
##lung	Gene_EXP:ACN9	2_3465735_T_C
##lung	Gene_EXP:TPD52L2	9_134036501_T_G
##lung	Gene_EXP:ACSF2	2_71393433_A_G,2_71424561_G_GT,2_71428456_T_A,2_71433365_T_TC
##lung	Gene_EXP:TPGS2	3_112202378_G_T
##lung	Gene_EXP:TPP1	3_197848065_G_C
##lung	Gene_EXP:ADA	4_39457622_A_G
##lung	Gene_EXP:TRIM21	18_50806833_C_G
##lung	Gene_EXP:ADAMTS14	19_52554226_G_A
##lung	Gene_EXP:TRIM33	4_78315728_T_G,5_176575310_A_C,6_136362716_T_G,12_14806481_T_G,22_42516026_A_G
##lung	Gene_EXP:ADCYAP1	12_96909915_A_C
##lung	Gene_EXP:ADNP2	9_41294004_C_A
##lung	Gene_EXP:TRIP10	14_20381224_T_G
##lung	Gene_EXP:ADTRP	4_20727343_G_C
##lung	Gene_EXP:TRIP11	1_230792766_C_G
##lung	Gene_EXP:AGA	11_124016277_A_G
##lung	Gene_EXP:TRIP6	17_78529677_G_C
##lung	Gene_EXP:AGBL4	2_217842134_T_C,2_217847379_A_G,2_217847583_C_T,2_217847883_G_A,2_217848003_A_G
##lung	Gene_EXP:TSC22D4	17_78558361_G_A
##lung	Gene_EXP:TSPAN8	14_59479381_T_C,14_59510888_CA_C,14_59473009_T_C,14_59498987_A_C,14_59476235_T_TCAAC
##lung	Gene_EXP:AGXT2L2	1_451649_A_AG,15_101875991_T_TC,2_217847583_C_T,2_217848003_A_G,2_217847883_G_A
##lung	Gene_EXP:TSR2	8_109271027_T_C,8_109271124_T_G
##lung	Gene_EXP:AGXT2L2	1_451649_A_AG,2_217847583_C_T,2_217848003_A_G,2_217847883_G_A,15_101875991_T_TC
##lung	Gene_EXP:TTC1	5_155013898_A_G
##lung	Gene_EXP:AHI1	2_102664958_A_C
##lung	Gene_EXP:TTC3	12_66128870_G_A
##lung	Gene_EXP:AIM1	11_124396830_G_A
##lung	Gene_EXP:TTC9B	17_74541739_G_A
##lung	Gene_EXP:ALDH3A1	21_41825867_C_T
##lung	Gene_EXP:TUBB	1_101786406_G_A
##lung	Gene_EXP:ALG14	12_27755086_G_GA
##lung	Gene_EXP:TUBGCP3	2_68528704_T_C,10_31363289_T_C,16_60358945_T_C
##lung	Gene_EXP:ALG9	14_76498312_C_T
##lung	Gene_EXP:TXNL4A	11_124397016_A_G
##lung	Gene_EXP:AMIGO2	19_2109072_C_T,19_2109158_T_C,19_2121317_C_T,19_2123329_A_G
##lung	Gene_EXP:UBA7	21_42543649_A_G
##lung	Gene_EXP:UBAP1	5_31510999_G_T
##lung	Gene_EXP:ANKMY1	12_103753400_C_A
##lung	Gene_EXP:UBE2H	2_9279286_C_T
##lung	Gene_EXP:ANKRD22	17_81206909_A_C
##lung	Gene_EXP:UROS	12_113100610_A_T,12_113102024_C_T,12_113115869_AG_A,12_113117141_G_A,12_113121642_A_G
##lung	Gene_EXP:ANKRD46	5_124701240_T_G
##lung	Gene_EXP:ANO1	4_36121402_A_G
##lung	Gene_EXP:USP30	5_70495058_G_T,6_57924451_G_T,X_71592597_A_T
##lung	Gene_EXP:ANO10	10_94340500_TA_T
##lung	Gene_EXP:VCL	10_97936313_A_C
##lung	Gene_EXP:ANO4	9_41294004_C_A
##lung	Gene_EXP:VEZF1	4_122258745_C_T
##lung	Gene_EXP:AP3M2	17_8888776_G_A
##lung	Gene_EXP:VTI1B	2_225401003_CTGG_C
##lung	Gene_EXP:APBB1	7_117548606_ATG_A
##lung	Gene_EXP:WASF3	15_67165360_A_G
##lung	Gene_EXP:ARID1B	1_169953900_G_GT
##lung	Gene_EXP:WDR18	19_985997_C_G
##lung	Gene_EXP:ARID5B	2_237753511_A_G,2_237821674_A_G
##lung	Gene_EXP:WDR26	20_63967788_C_T
##lung	Gene_EXP:ARL6IP6	2_178707495_G_T,4_51995319_G_T,17_42806693_T_C,17_43189040_A_C
##lung	Gene_EXP:WDR55	11_2335471_C_T
##lung	Gene_EXP:WHAMM	15_59207967_A_G,15_59207979_A_G,15_59207981_C_G,15_59207987_T_C
##lung	Gene_EXP:ARSD	1_101786406_G_A
##lung	Gene_EXP:ARVCF	10_133626829_C_T,15_71256598_T_C
##lung	Gene_EXP:ZBED5	5_138430313_A_C,5_176529597_A_C,7_99486962_A_C,11_62807431_T_G,14_69704655_C_T
##lung	Gene_EXP:ASTN1	7_152816454_C_T
##lung	Gene_EXP:ZCCHC11	22_36566306_C_G
##lung	Gene_EXP:ATG4D	19_12392240_G_A,19_12392282_A_G,19_12393278_A_G,19_12431541_A_G,19_12433052_A_G
##lung	Gene_EXP:ZDHHC13	2_130342165_A_C,5_141193109_A_G,14_69704655_C_T
##lung	Gene_EXP:ATHL1	3_125578903_AT_A
##lung	Gene_EXP:ZDHHC5	7_101136942_T_G,16_89729370_A_C
##lung	Gene_EXP:ATP6V0B	17_78529723_C_G
##lung	Gene_EXP:ZEB1	3_58285236_T_C,9_41905830_C_G
##lung	Gene_EXP:ATRIP	19_815835_G_A
##lung	Gene_EXP:ZFHX2	9_27567147_C_T
##lung	Gene_EXP:AVPI1	3_157413999_A_C
##lung	Gene_EXP:ZFP82	3_33120406_C_T
##lung	Gene_EXP:AXL	14_73713060_A_C
##lung	Gene_EXP:ZNF250	5_135888024_G_T
##lung	Gene_EXP:BAALC	15_67236036_T_G
##lung	Gene_EXP:ZNF292	20_1445690_A_C,2_130342165_A_C,1_89935566_A_C,5_141193109_A_G,10_62069760_A_C
##lung	Gene_EXP:BIRC7	17_78507511_T_C,17_78510525_G_A
##lung	Gene_EXP:BTG2	6_34872273_T_G
##lung	Gene_EXP:ZNF292	20_1445690_A_C,5_141193109_A_G,2_130342165_A_C,10_62069760_A_C,1_89935566_A_C
##lung	Gene_EXP:C10orf76	2_169557387_G_GA
##lung	Gene_EXP:C11orf48	6_34872273_T_G,14_73287170_T_G,7_36299099_C_T,12_119770711_C_T,7_55155865_C_G
##lung	Gene_EXP:ZNF295	11_113854221_T_C
##lung	Gene_EXP:ZNF296	2_222624260_G_A
##lung	Gene_EXP:C12orf57	1_103082763_C_G
##lung	Gene_EXP:ZNF345	1_153772281_T_G,6_53654807_C_T
##lung	Gene_EXP:C14orf142	11_66055499_T_G
##lung	Gene_EXP:ZNF420	6_53654807_C_T
##lung	Gene_EXP:C16orf59	2_217847583_C_T,2_217847883_G_A
##lung	Gene_EXP:ZNF594	19_12433052_A_G
##lung	Gene_EXP:C17orf75	6_32183680_C_G
##lung	Gene_EXP:ZNF750	19_15794719_C_A,19_15807367_G_T
##lung	Gene_EXP:C1orf198	3_98581510_A_C,5_1079483_A_C,12_121263747_T_G,20_6215106_T_C
##lung	Gene_EXP:ZNF93	17_47361586_C_T,17_47402080_A_C
##lung	Gene_EXP:ZSCAN16	7_26185482_G_A
##lung	Gene_EXP:C5orf34	7_22511655_A_C
##lung	Gene_EXP:C5orf54	19_10499560_A_G
##lung	Gene_EXP:C9orf123	9_41898374_T_G
##lung	Gene_EXP:C9orf69	2_9954891_G_GT,2_9996464_T_C
##lung	Gene_EXP:CABP7	1_46344858_A_G
##lung	Gene_EXP:CACNA2D2	15_67236036_T_G
##lung	Gene_EXP:CASP8	17_75904383_G_C
##lung	Gene_EXP:CASP8AP2	6_109431362_C_A,10_24584658_G_C
##lung	Gene_EXP:CAV1	10_133626829_C_T
##lung	Gene_EXP:CBLN2	1_170016655_A_G
##lung	Gene_EXP:CCDC102A	17_34982963_C_CT
##lung	Gene_EXP:CCDC113	16_67199408_A_C
##lung	Gene_EXP:CCDC142	9_85773919_A_G
##lung	Gene_EXP:CD55	5_113384951_C_A
##lung	Gene_EXP:CD63	6_87656990_C_T
##lung	Gene_EXP:CD97	4_8036186_A_G,5_141193109_A_G,7_108514148_A_C,12_108517007_T_G,17_80137479_A_T
##lung	Gene_EXP:CDC23	22_37143673_T_C
##lung	Gene_EXP:CDC25A	19_10793898_A_C
##lung	Gene_EXP:CDCA5	2_217847583_C_T
##lung	Gene_EXP:CDCP1	22_24253656_C_G
##lung	Gene_EXP:CEBPD	6_150926303_A_G
##lung	Gene_EXP:CECR2	15_30596563_A_G
##lung	Gene_EXP:CENPM	19_10793898_A_C
##lung	Gene_EXP:CES2	8_17085328_C_T
##lung	Gene_EXP:CHGB	15_67236036_T_G
##lung	Gene_EXP:CHN1	17_81206909_A_C
##lung	Gene_EXP:CHST8	11_5901136_G_A
##lung	Gene_EXP:CLCNKA	10_31363289_T_C
##lung	Gene_EXP:CLIP3	5_163482681_G_A
##lung	Gene_EXP:CLPP	7_95587100_T_G
##lung	Gene_EXP:CLSPN	15_62651935_A_G,15_62657955_G_C
##lung	Gene_EXP:CNKSR3	17_78539866_T_C
##lung	Gene_EXP:CNPY4	17_48728228_G_A
##lung	Gene_EXP:CPNE8	X_24055660_C_A
##lung	Gene_EXP:CRNKL1	19_49365896_G_C
##lung	Gene_EXP:CSF2	X_73845822_T_G
##lung	Gene_EXP:CSNK1A1	20_47658268_C_G
##lung	Gene_EXP:CSNK2A1	7_4077030_A_G,8_119240272_G_C,20_36185166_C_G
##lung	Gene_EXP:CSRNP1	2_95859892_G_T,8_7952044_T_C
##lung	Gene_EXP:CTRB2	4_37433902_C_T,17_32933237_C_T,17_32934364_G_A
##lung	Gene_EXP:CTSL1	10_120866541_C_T,10_62069760_A_C,X_52907336_A_C,20_57610424_A_C,17_75130604_T_G
##lung	Gene_EXP:CTSL1	17_75130604_T_G,10_62069760_A_C,10_120866541_C_T,7_6857531_A_G,20_57610424_A_C
##lung	Gene_EXP:CTSL1	17_75130604_T_G,10_62069760_A_C,10_120866541_C_T,7_6857531_A_G,X_52907336_A_C
##lung	Gene_EXP:CTSL1	17_75130604_T_G,10_62069760_A_C,7_6857531_A_G,10_120866541_C_T,20_57610424_A_C
##lung	Gene_EXP:CXCL2	X_89922110_G_C
##lung	Gene_EXP:CXXC1	2_119254595_G_A,3_112199369_A_G
##lung	Gene_EXP:DALRD3	1_13418327_A_C,1_244857989_TA_T,2_232856863_A_C,15_30553868_T_C
##lung	Gene_EXP:DAPL1	14_69704655_C_T,2_232484578_G_C,21_46245169_G_A,17_7701545_A_C,2_121732218_A_C
##lung	Gene_EXP:DCAKD	6_32183680_C_G
##lung	Gene_EXP:DCTD	8_7429219_C_T
##lung	Gene_EXP:DCUN1D2	10_31363289_T_C
##lung	Gene_EXP:DDR1	2_174801578_A_G,4_89936328_G_A
##lung	Gene_EXP:DLX5	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G
##lung	Gene_EXP:DNMT3A	22_36566306_C_G
##lung	Gene_EXP:DOK6	18_12840880_T_C
##lung	Gene_EXP:DPY19L3	15_65564315_G_A,17_78425362_G_A,17_78427070_C_T
##lung	Gene_EXP:DPYSL4	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G,2_217842134_T_C,2_217847379_A_G
##lung	Gene_EXP:DPYSL4	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G,2_217847379_A_G,2_217842134_T_C
##lung	Gene_EXP:DQX1	1_113907966_C_T
##lung	Gene_EXP:DSC3	11_18285498_T_C,11_18311889_A_T
##lung	Gene_EXP:DTL	2_29239654_G_A
##lung	Gene_EXP:DTX3L	4_185267219_TA_T
##lung	Gene_EXP:DUSP3	11_71565805_A_G
##lung	Gene_EXP:DUSP5	6_32183680_C_G
##lung	Gene_EXP:DYRK1B	22_36566306_C_G
##lung	Gene_EXP:DYRK2	2_157538567_C_G,9_13219571_T_C
##lung	Gene_EXP:E2F4	17_3727947_A_G
##lung	Gene_EXP:EBP	14_91475998_T_A
##lung	Gene_EXP:ELL2	6_32183680_C_G
##lung	Gene_EXP:ELOVL1	1_203683316_A_G,1_203698281_T_C
##lung	Gene_EXP:EPSTI1	2_226796327_T_C
##lung	Gene_EXP:ERAP2	5_96986715_C_T,5_96917400_T_C,5_97003398_AC_A,5_96908881_A_C,5_96895179_A_ATT
##lung	Gene_EXP:ERAP2	5_96986715_C_T,5_96917400_T_C,5_97003398_AC_A,5_97027703_C_T,5_96908881_A_C
##lung	Gene_EXP:ERAP2	5_96986715_C_T,5_96917400_T_C,5_97027703_C_T,5_96996381_TC_T,5_97003398_AC_A
##lung	Gene_EXP:EREG	17_50677651_A_G
##lung	Gene_EXP:ERH	6_47579334_T_TAA
##lung	Gene_EXP:ERLEC1	10_52768593_C_G
##lung	Gene_EXP:ERO1L	6_47579334_T_TAA
##lung	Gene_EXP:ESF1	2_231163667_A_C,10_37197397_A_C,11_124877210_T_G,20_26081320_C_T
##lung	Gene_EXP:EVL	7_33264495_A_G
##lung	Gene_EXP:EVPL	15_84798628_G_A
##lung	Gene_EXP:FAM114A1	2_217847583_C_T
##lung	Gene_EXP:FAM174A	1_198735165_C_T
##lung	Gene_EXP:FBLN7	12_96909915_A_C
##lung	Gene_EXP:FBXO21	17_47835431_A_G,5_176575304_A_C,10_37162775_G_C,2_223598038_G_T,2_130173628_A_C
##lung	Gene_EXP:FCRLB	10_102365533_A_G,12_49974763_C_G,2_118982373_A_G,1_183239405_G_A,9_41189241_T_C
##lung	Gene_EXP:FCRLB	12_49974763_C_G,1_183239405_G_A,10_102365533_A_G,2_118982373_A_G,X_52907336_A_C
##lung	Gene_EXP:FEZ2	X_108735142_T_G
##lung	Gene_EXP:FGF9	13_32131648_A_G
##lung	Gene_EXP:FGFBP1	2_65069680_A_C,17_81206909_A_C
##lung	Gene_EXP:FHL3	1_50200843_C_T
##lung	Gene_EXP:FLNA	3_118902653_C_T
##lung	Gene_EXP:FN1	22_16697696_G_A
##lung	Gene_EXP:FSTL1	1_146962991_T_C
##lung	Gene_EXP:FYN	X_120253978_C_CTGA
##lung	Gene_EXP:GALNT3	3_7680310_G_A,6_150945502_T_G
##lung	Gene_EXP:GALNT6	X_154465468_T_C
##lung	Gene_EXP:GBP1	3_55480738_A_T
##lung	Gene_EXP:GEMIN5	5_71233740_G_C
##lung	Gene_EXP:GGCX	19_39875355_A_T
##lung	Gene_EXP:GLIPR1	16_55398_G_T
##lung	Gene_EXP:GLIS3	1_211372116_TC_T,6_121115274_C_T
##lung	Gene_EXP:GLTP	2_182994745_T_C
##lung	Gene_EXP:GNAO1	10_133626013_G_A
##lung	Gene_EXP:GNS	11_1163029_C_G
##lung	Gene_EXP:GPC1	3_184278425_C_T
##lung	Gene_EXP:GPR87	19_15807367_G_T
##lung	Gene_EXP:GPX1	19_38802052_C_G,6_43512063_C_G,11_117913802_T_G,12_49974763_C_G,2_85665590_T_G
##lung	Gene_EXP:HADHB	19_48942517_C_T,19_48944320_G_A,19_48944456_G_A
##lung	Gene_EXP:HDAC6	13_45503246_G_A
##lung	Gene_EXP:HIBADH	1_485270_G_A
##lung	Gene_EXP:HIRA	9_41341340_C_T
##lung	Gene_EXP:HK1	16_74886293_G_A
##lung	Gene_EXP:HMOX1	1_183239405_G_A,2_86785910_T_G,20_39018962_A_C
##lung	Gene_EXP:HOXA1	6_112201651_G_A
##lung	Gene_EXP:HPS1	9_136453326_A_G,9_136463607_G_A,9_136476782_G_A
##lung	Gene_EXP:HSD17B10	5_24511259_C_T
##lung	Gene_EXP:ICAM1	8_12358868_A_G
##lung	Gene_EXP:ID4	4_9334816_T_C
##lung	Gene_EXP:IDH1	7_16674308_A_AT
##lung	Gene_EXP:IER5L	9_34623341_A_G
##lung	Gene_EXP:IFI35	12_15589379_GA_G
##lung	Gene_EXP:IFIT3	18_50806833_C_G
##lung	Gene_EXP:IFIT5	6_169632990_G_A,6_169665646_G_A
##lung	Gene_EXP:IGDCC3	20_32917383_C_T
##lung	Gene_EXP:IKBKAP	10_52768593_C_G
##lung	Gene_EXP:IL15RA	22_36566306_C_G
##lung	Gene_EXP:IL17RB	19_44506064_G_T
##lung	Gene_EXP:IL21	16_74410940_A_G
##lung	Gene_EXP:IL31RA	4_20727343_G_C
##lung	Gene_EXP:IMMP1L	17_47402080_A_C,17_47592062_T_TA,17_47656843_CTTT_C,17_47673230_G_A
##lung	Gene_EXP:INADL	2_241246976_C_T,3_58285236_T_C,16_75166518_T_C
##lung	Gene_EXP:ITGA3	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G
##lung	Gene_EXP:ITPR1	4_8036186_A_G
##lung	Gene_EXP:ITPRIPL1	2_24209270_T_C
##lung	Gene_EXP:KCNJ11	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G,2_217848559_G_A
##lung	Gene_EXP:KCNK6	17_81206909_A_C
##lung	Gene_EXP:KCNK9	10_28880454_A_G
##lung	Gene_EXP:KCNMB2	18_50806833_C_G
##lung	Gene_EXP:KCTD18	9_60935641_T_G
##lung	Gene_EXP:KCTD21	4_86764643_T_G,4_86782277_A_C,4_86785379_C_T,11_129888749_A_C,14_23968860_T_C
##lung	Gene_EXP:KDM1B	15_65447029_G_A
##lung	Gene_EXP:KHK	2_217847583_C_T,2_217848003_A_G
##lung	Gene_EXP:KHSRP	4_119158232_G_A
##lung	Gene_EXP:KIAA1239	7_83961536_T_C
##lung	Gene_EXP:KIDINS220	5_50403159_C_A
##lung	Gene_EXP:KLK6	4_48170201_C_T,4_48170249_G_A
##lung	Gene_EXP:KLRG1	21_42543649_A_G,21_42565845_G_A
##lung	Gene_EXP:KMT2C	1_64857635_C_A,6_166586261_A_C,15_40272241_A_C,17_4932735_A_C,17_47835431_A_G

[표 10]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value)를 산출한 결과가 아래 [표 11]에 정리되어있다.

또한, [표 10]에 제시된 FRH들이 포함되어 발현된 유전자와 각각의 lung(폐암) 약물과의 상관도(P-value)를 산출한 결과가 아래 [도 29]에 정리되어있다.

Correlation between gene expression and FRH

Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)
POLR3K	1.67E-06	LIG1	0.000297009	NDUFAB1	0.000622562
ISLR2	1.88E-06	ZDHHC13	0.000298381	EPHB1	0.000625456
TFDP3	3.05E-06	FOXI1	0.000305171	ZNFX1	0.000630994
RTN4	6.47E-06	HRAS	0.000307846	CTSO	0.000632192
AGBL4	1.02E-05	GRID2	0.00032141	IL6ST	0.000633631
SNRNP25	1.12E-05	CHAF1B	0.000323273	GHSR	0.000650493
AGXT2L2	2.80E-05	LY96	0.00032386	GRM8	0.000660785
KCNJ11	3.26E-05	DLX5	0.000324205	IFNG	0.000678124
WDR34	3.35E-05	LRRN3	0.000331053	BHLHE22	0.0006809
ZWINT	3.63E-05	PAX2	0.000333304	SNRPD1	0.000688253
TMEM240	3.86E-05	MXRA7	0.000337717	PDCD6IP	0.000688266
ZNF833P	5.04E-05	PPAP2A	0.000338058	NEK6	0.000695793
NOTCH4	5.11E-05	SGPP1	0.000340151	HRH1	0.000716457
LHFPL2	5.92E-05	NPC1	0.000344985	EIF4E1B	0.000720264
TMPO	6.23E-05	DNA2	0.000351331	TBPL2	0.000740785
DPYSL4	6.74E-05	ARVCF	0.00035556	AIF1L	0.000747275
CD4	8.15E-05	CDCA5	0.00036589	BRI3BP	0.000757983
PRDX2	8.25E-05	RFC5	0.000369769	RPS6KL1	0.000776133
C1orf194	8.40E-05	DLGAP3	0.000371161	SLC25A10	0.000776179
C2orf15	8.85E-05	NOL4	0.000378602	UBE2T	0.000781573
MSN	8.89E-05	RIC3	0.000378764	IFI44	0.000782934
SMARCE1	0.000103143	GRN	0.000381551	IFI6	0.000783873
CST11	0.000110776	SYK	0.000406629	RAD51D	0.000803271
CPLX2	0.000116401	GPX8	0.000423944	ICAM1	0.000814308
PLEKHM1	0.000121608	RASSF8	0.000425007	UNG	0.000821896
DMRTA2	0.000122743	KHK	0.000427192	HLA-E	0.000826478
MGAT5B	0.00012583	TLN2	0.00042859	KIAA0895	0.000849579
RGMA	0.000130891	CHAF1A	0.00044724	PCYT1B	0.000855837
HIST1H3C	0.000137766	PBK	0.000456897	TDG	0.000865187
DEPDC5	0.000151458	MBD3	0.000463435	SNAP23	0.000883492
HCN4	0.000162105	DBNDD1	0.00047096	CAMSAP3	0.000884723
ZBTB16	0.000163352	H6PD	0.000471502	SAC3D1	0.000886594
LSM4	0.000164338	CDHR4	0.000472181	E4F1	0.000886723
ATP4B	0.00016945	ZNF236	0.0004749	UPP1	0.000911641
DONSON	0.000171437	CDC6	0.000478257	HSPB11	0.00091532
TRMU	0.000176173	IGF2BP2	0.000490963	RFX3	0.000915936
CHST9	0.000176885	ERAP1	0.000497491	CREB3L1	0.000922729
RASAL1	0.000177467	HIST1H4B	0.000500157	PACSIN1	0.000924656
TBX5	0.000198886	HTR1E	0.000506038	MZT2B	0.000925961
SEMA4D	0.000200406	ZNF219	0.00051924	KIF22	0.000932174
SLC26A5	0.000205346	SOCS5	0.000521943	NSMAF	0.000932954
FUT1	0.000207729	AHNAK2	0.000527886	CALU	0.000952122
CAMKV	0.000210417	ATP5L	0.000530816	C16orf59	0.000959405
TMEM176B	0.000213389	HNRNPA1L2	0.00053364	SP110	0.000964561
SFXN3	0.000221559	USP32	0.000533881	ZNF80	0.000965145
CHRNB2	0.000232469	MYT1	0.000536245	PEA15	0.000965531
HIPK4	0.000233751	ESCO2	0.000538795	ZNF385B	0.000971107
KCNJ3	0.000238276	SLC25A4	0.000540249	KDELR3	0.000975043
NUDT16L1	0.000239911	OPCML	0.000541145	ADRA1A	0.000982021
DRD2	0.000245153	TGOLN2	0.000544763
LZTS1	0.000253954	HMGN3	0.000558519
NUP62CL	0.000254788	BRCA1	0.000567047
RABIF	0.000256869	KCNK17	0.000567484
TOR2A	0.000260969	CCDC34	0.00057728
RRM1	0.000264266	ITIH1	0.000578889
OVOL2	0.00026549	POLE	0.000587318
ITGA3	0.000269067	NBAS	0.000588262
CELF3	0.000270543	RAD51AP1	0.000600158
SNX10	0.000270832	AIF1	0.000600205
RNF208	0.000283861	FRAT2	0.000607255
DPY19L1	0.000289206	APCDD1	0.000610283
KCND3	0.000291824	HRH3	0.000621755

이들 [표 11] 및 [도 29]로부터 [표 11] 및 [도 29]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 폐암 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

육종암(bone) 약물에 대한 반응성 바이오 마커

Cancer_Class	Gene_exp	바이오 마커 (발현조절 FRH 변이세트)
##bone	Gene_EXP:SEPT5	1_26457907_T_G
##bone	Gene_EXP:ABCA5	6_151015603_C_G
##bone	Gene_EXP:ABHD6	1_26457907_T_G,12_52771095_C_G,22_18847351_G_C,22_21127217_C_G,5_141432375_A_C
##bone	Gene_EXP:ABHD6	12_52771095_C_G,1_26457907_T_G,5_141432375_A_C,2_119366546_A_G,22_18847351_G_C
##bone	Gene_EXP:ACACB	1_26457907_T_G,22_18847351_G_C
##bone	Gene_EXP:ACTN2	1_26457907_T_G,22_18847351_G_C,22_21127217_C_G
##bone	Gene_EXP:ACTR3B	19_5680513_A_C
##bone	Gene_EXP:ACVR1B	1_26457907_T_G
##bone	Gene_EXP:ACVR2B	20_10639627_G_A
##bone	Gene_EXP:ADAM19	14_68882917_A_G,22_21127217_C_G,22_21283300_G_C
##bone	Gene_EXP:ADRB1	1_26457907_T_G
##bone	Gene_EXP:ADRB3	1_26457907_T_G
##bone	Gene_EXP:AHNAK2	3_52520584_A_C
##bone	Gene_EXP:AKAP7	1_26457907_T_G
##bone	Gene_EXP:ALDH5A1	2_100470432_G_A,2_100470504_C_T,2_100470642_C_T,2_178612907_A_C
##bone	Gene_EXP:ALG6	1_26457907_T_G
##bone	Gene_EXP:ALS2CR8	7_5300364_T_G,11_64118302_A_C
##bone	Gene_EXP:ANKRD28	1_26457907_T_G
##bone	Gene_EXP:ANXA11	1_26457907_T_G
##bone	Gene_EXP:APOBEC3B	9_131134849_T_C
##bone	Gene_EXP:ARHGAP19	22_22643666_C_G
##bone	Gene_EXP:ARHGAP44	16_55810697_G_T,16_55813139_C_T
##bone	Gene_EXP:ARID2	1_26457907_T_G
##bone	Gene_EXP:ASGR1	1_26457907_T_G,5_141432375_A_C,15_42142087_A_C,22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:ASPH	1_183122094_C_G,3_180647255_T_TA
##bone	Gene_EXP:ASRGL1	6_151015603_C_G
##bone	Gene_EXP:ATG10	3_120173274_C_G
##bone	Gene_EXP:ATP11C	1_26457907_T_G
##bone	Gene_EXP:ATP1A1	1_26457907_T_G
##bone	Gene_EXP:ATP1B2	16_3027533_A_G
##bone	Gene_EXP:ATP2B3	1_26457907_T_G,17_7604041_A_C
##bone	Gene_EXP:ATP6V0B	1_9850602_T_G
##bone	Gene_EXP:AXL	4_42616004_T_TA,4_42616121_A_G
##bone	Gene_EXP:BAHCC1	9_39360952_G_A
##bone	Gene_EXP:BAZ2A	19_46321845_A_C
##bone	Gene_EXP:BAZ2B	2_97167816_C_T
##bone	Gene_EXP:BCL11B	1_26457907_T_G,5_141432375_A_C,22_22643666_C_G
##bone	Gene_EXP:BDKRB1	22_22643666_C_G
##bone	Gene_EXP:BHLHE22	1_26457907_T_G,22_21127217_C_G
##bone	Gene_EXP:BMP4	15_69422319_A_C
##bone	Gene_EXP:BRF2	7_37907554_A_G,22_21283300_G_C
##bone	Gene_EXP:BTBD17	1_26457907_T_G
##bone	Gene_EXP:C11orf24	1_26457907_T_G,1_214608652_G_A,8_38170001_A_G,15_42142087_A_C
##bone	Gene_EXP:C1orf168	14_61530508_C_T
##bone	Gene_EXP:C1orf27	15_25177023_G_C
##bone	Gene_EXP:C21orf7	21_32784788_C_T
##bone	Gene_EXP:C8orf33	1_152805392_A_G,1_152805488_G_A
##bone	Gene_EXP:CACHD1	1_26457907_T_G,2_119366546_A_G
##bone	Gene_EXP:CACNA1H	1_26457907_T_G
##bone	Gene_EXP:CAP1	1_26457907_T_G
##bone	Gene_EXP:CASP4	3_180647255_T_TA
##bone	Gene_EXP:CCDC80	16_53649037_C_T
##bone	Gene_EXP:CCND1	15_69422319_A_C
##bone	Gene_EXP:CD44	1_26457907_T_G,1_149813302_A_C,6_151015603_C_G
##bone	Gene_EXP:CD59	6_151015603_C_G
##bone	Gene_EXP:CDC42EP3	22_21283300_G_C
##bone	Gene_EXP:CDK13	1_26457907_T_G,22_30937565_T_G
##bone	Gene_EXP:CDS1	1_26457907_T_G,1_219210601_T_G
##bone	Gene_EXP:CELSR2	1_26457907_T_G
##bone	Gene_EXP:CMBL	17_62701571_G_A
##bone	Gene_EXP:CNOT6	22_22643666_C_G
##bone	Gene_EXP:COL4A5	3_38092947_A_G
##bone	Gene_EXP:COQ5	16_24877133_C_T,20_499958_CAA_C
##bone	Gene_EXP:COX19	1_26457907_T_G,22_24658344_C_G
##bone	Gene_EXP:CRIPAK	19_3449070_T_C,6_160247199_T_G,9_107488139_A_C,4_48557504_A_G,9_137101572_A_C
##bone	Gene_EXP:CRISPLD1	16_55811012_TA_T
##bone	Gene_EXP:CRMP1	1_26457907_T_G,22_21127217_C_G
##bone	Gene_EXP:CRYBG3	1_149813302_A_C,22_21127217_C_G
##bone	Gene_EXP:CSAD	1_26457907_T_G
##bone	Gene_EXP:CSRP2BP	9_79705958_C_T,1_26457907_T_G,17_65225089_T_C,4_8471209_T_C,5_41181389_G_T
##bone	Gene_EXP:CSRP2BP	9_79705958_C_T,5_41181389_G_T,1_26457907_T_G,17_65225089_T_C,4_8471209_T_C
##bone	Gene_EXP:CSRP3	2_112722995_T_G
##bone	Gene_EXP:CTGF	10_99533046_A_G
##bone	Gene_EXP:CUX2	22_21127217_C_G
##bone	Gene_EXP:CYP2J2	1_26457907_T_G,5_141432375_A_C,15_42142087_A_C
##bone	Gene_EXP:CYP4F22	22_21127217_C_G
##bone	Gene_EXP:DDO	1_154732996_T_G
##bone	Gene_EXP:DFNA5	11_24729296_G_A
##bone	Gene_EXP:DGKD	11_62825464_G_C,22_24252424_G_C
##bone	Gene_EXP:DKK2	1_26457907_T_G
##bone	Gene_EXP:DKK3	11_24729296_G_A
##bone	Gene_EXP:DLG2	1_26457907_T_G,22_18847351_G_C,22_21127217_C_G
##bone	Gene_EXP:DLGAP1	22_21127217_C_G
##bone	Gene_EXP:DMRTA1	7_72949311_A_C
##bone	Gene_EXP:DNMT3A	1_26457907_T_G
##bone	Gene_EXP:DOCK10	18_76968158_T_C
##bone	Gene_EXP:DOCK9	2_87800520_G_A,17_80065379_A_G
##bone	Gene_EXP:DPP9	22_21127217_C_G
##bone	Gene_EXP:DPYSL5	1_26457907_T_G,22_21127217_C_G
##bone	Gene_EXP:DRAP1	1_26457907_T_G
##bone	Gene_EXP:DST	22_22643666_C_G
##bone	Gene_EXP:DTX3L	1_26457907_T_G
##bone	Gene_EXP:E2F5	8_22080213_T_C
##bone	Gene_EXP:E2F6	1_26457907_T_G
##bone	Gene_EXP:EBF3	1_26457907_T_G
##bone	Gene_EXP:EFHD2	1_26457907_T_G,12_48769033_A_C,19_3179506_A_C
##bone	Gene_EXP:EFNB1	1_26457907_T_G
##bone	Gene_EXP:EGFL7	22_22643666_C_G
##bone	Gene_EXP:EGFLAM	2_217817751_A_G,2_217818534_A_G
##bone	Gene_EXP:ELL2	22_22643666_C_G
##bone	Gene_EXP:ELOVL1	22_24252424_G_C
##bone	Gene_EXP:ENC1	1_26457907_T_G,15_69422319_A_C
##bone	Gene_EXP:ENDOD1	1_201000288_T_G
##bone	Gene_EXP:ENPP3	1_26457907_T_G,22_22643666_C_G
##bone	Gene_EXP:EPC1	19_6744459_C_G,19_42723940_A_C
##bone	Gene_EXP:EPHA7	3_42691976_T_C,7_100958772_C_T
##bone	Gene_EXP:ERO1L	1_26457907_T_G,5_141432375_A_C,10_6515090_A_C
##bone	Gene_EXP:EVI2A	1_26457907_T_G
##bone	Gene_EXP:EVI2B	10_46462341_C_A
##bone	Gene_EXP:EXT2	7_100959168_T_C,7_100959203_T_C
##bone	Gene_EXP:EZH2	1_26457907_T_G,22_18847351_G_C
##bone	Gene_EXP:FAH	22_22643666_C_G
##bone	Gene_EXP:FAIM	10_122983276_G_A,1_26457907_T_G,5_141432375_A_C,22_24252424_G_C,15_84654249_A_C
##bone	Gene_EXP:FAM124A	1_26457907_T_G,1_219210601_T_G
##bone	Gene_EXP:FAM19A5	22_22643666_C_G
##bone	Gene_EXP:FAM69A	4_105679196_A_C
##bone	Gene_EXP:FAM84B	13_24951498_G_C
##bone	Gene_EXP:FAN1	21_32784788_C_T
##bone	Gene_EXP:FBN2	3_52520584_A_C
##bone	Gene_EXP:FBXO15	16_3526396_A_T,22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:FCGRT	1_26457907_T_G,5_141432375_A_C,22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:FEZF1	1_26457907_T_G,22_22643666_C_G
##bone	Gene_EXP:FLII	3_52520584_A_C
##bone	Gene_EXP:FNBP1	15_69422319_A_C
##bone	Gene_EXP:FOXC1	1_26457907_T_G
##bone	Gene_EXP:FOXK2	17_57105517_C_T,17_57110197_C_G
##bone	Gene_EXP:FREM1	2_205740456_T_G
##bone	Gene_EXP:FRMD6	1_26457907_T_G
##bone	Gene_EXP:FSTL3	16_81160923_C_T
##bone	Gene_EXP:FUCA2	1_26457907_T_G,5_141432375_A_C,22_18847351_G_C,1_219210601_T_G,22_22643666_C_G
##bone	Gene_EXP:FUCA2	5_141432375_A_C,1_26457907_T_G,22_18847351_G_C,1_219210601_T_G,22_22643666_C_G
##bone	Gene_EXP:FUT11	1_26457907_T_G,17_79044046_T_C,22_21127217_C_G,22_22643666_C_G,22_24252424_G_C
##bone	Gene_EXP:FZD3	1_26457907_T_G
##bone	Gene_EXP:GAL	22_20751638_T_G
##bone	Gene_EXP:GAL3ST3	1_26457907_T_G
##bone	Gene_EXP:GALNT10	13_99295007_C_T,13_99314037_A_G
##bone	Gene_EXP:GBE1	1_26457907_T_G,22_22643666_C_G
##bone	Gene_EXP:GCNT1	1_26457907_T_G,22_22643666_C_G
##bone	Gene_EXP:GDF6	2_75493538_G_A
##bone	Gene_EXP:GPC2	5_141432375_A_C
##bone	Gene_EXP:GPR155	22_22643666_C_G
##bone	Gene_EXP:GSN	2_170993697_G_A
##bone	Gene_EXP:GSTA4	17_80065379_A_G
##bone	Gene_EXP:GTF2IRD1	13_99295924_C_A,16_4823959_A_C
##bone	Gene_EXP:GYG1	3_38550915_A_G,3_38551637_T_TG,5_141432375_A_C,12_52771095_C_G
##bone	Gene_EXP:H2AFY2	22_22643666_C_G
##bone	Gene_EXP:HIF3A	1_26457907_T_G,16_3027533_A_G
##bone	Gene_EXP:HOOK1	1_26457907_T_G
##bone	Gene_EXP:HOXB13	1_26457907_T_G
##bone	Gene_EXP:HOXD10	1_26457907_T_G
##bone	Gene_EXP:HOXD13	1_26457907_T_G
##bone	Gene_EXP:HOXD9	5_140829601_T_G
##bone	Gene_EXP:HR	1_26457907_T_G
##bone	Gene_EXP:HS3ST3B1	5_141432375_A_C,15_42142087_A_C
##bone	Gene_EXP:HS3ST4	1_26457907_T_G,12_52771095_C_G
##bone	Gene_EXP:ICAM4	1_26457907_T_G
##bone	Gene_EXP:IKBIP	5_141636680_A_C
##bone	Gene_EXP:IL13RA1	1_26457907_T_G
##bone	Gene_EXP:IL1R1	11_66624536_A_C
##bone	Gene_EXP:IQGAP1	11_1246628_A_C,12_109139615_A_C
##bone	Gene_EXP:IRS2	1_26457907_T_G,15_69422319_A_C,22_22643666_C_G
##bone	Gene_EXP:ITFG2	1_26457907_T_G
##bone	Gene_EXP:ITGBL1	1_26457907_T_G
##bone	Gene_EXP:ITM2A	1_26457907_T_G
##bone	Gene_EXP:ITPRIPL1	22_36800827_G_A,22_36800927_C_A
##bone	Gene_EXP:IVD	4_144719002_C_T
##bone	Gene_EXP:JAKMIP2	22_21127217_C_G
##bone	Gene_EXP:JHDM1D	22_21127217_C_G
##bone	Gene_EXP:JPH1	1_26457907_T_G,19_32643405_T_C
##bone	Gene_EXP:KANSL2	1_26457907_T_G,12_94248247_C_T
##bone	Gene_EXP:KAT2B	19_17618863_T_TG,19_17618978_T_G,22_22643666_C_G
##bone	Gene_EXP:KDSR	22_21127217_C_G
##bone	Gene_EXP:KHK	1_184808038_A_C,17_75517573_T_C
##bone	Gene_EXP:KIAA1456	1_26457907_T_G,3_52520584_A_C,15_25177023_G_C,22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:KIAA1958	1_26457907_T_G
##bone	Gene_EXP:KIF2A	11_102186007_C_T
##bone	Gene_EXP:KLHL23	1_26457907_T_G,5_141432375_A_C
##bone	Gene_EXP:KMO	22_21127217_C_G
##bone	Gene_EXP:KRT25	1_26457907_T_G,22_21127217_C_G,22_22643666_C_G,22_24658344_C_G
##bone	Gene_EXP:L3MBTL1	8_22080213_T_C
##bone	Gene_EXP:LARP4	19_21767500_C_T
##bone	Gene_EXP:LGALS1	1_26457907_T_G,11_62825464_G_C,22_22643666_C_G
##bone	Gene_EXP:LGALS3	1_26457907_T_G,5_141432375_A_C,1_149813302_A_C,3_51333222_A_C,22_24252424_G_C
##bone	Gene_EXP:LGALS3	1_26457907_T_G,9_83001013_C_A,5_141432375_A_C,1_149813302_A_C,7_100760409_A_C
##bone	Gene_EXP:LIM2	1_193249713_C_G
##bone	Gene_EXP:LIMS1	8_138630731_T_C
##bone	Gene_EXP:LINGO1	1_26457907_T_G,11_66624536_A_C,22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:LIPI	1_26457907_T_G,5_141432375_A_C,15_25177023_G_C
##bone	Gene_EXP:LMBR1L	7_72949311_A_C,12_109266204_T_G,20_35697711_A_C
##bone	Gene_EXP:LMNA	10_68691523_T_C
##bone	Gene_EXP:LMO2	1_26457907_T_G,5_141432375_A_C,11_1246628_A_C,15_25177023_G_C
##bone	Gene_EXP:LMO3	1_26457907_T_G
##bone	Gene_EXP:LONRF1	1_26457907_T_G,15_42142087_A_C,22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:LPHN1	1_225937656_T_G,16_3027533_A_G,22_21283300_G_C
##bone	Gene_EXP:LPP	1_26457907_T_G
##bone	Gene_EXP:LRP10	1_26457907_T_G,12_52771095_C_G,22_22643666_C_G
##bone	Gene_EXP:LRRC15	1_161042141_T_G
##bone	Gene_EXP:LRRC4B	16_3543521_G_A,16_3590476_C_T,16_3606556_G_A,22_21127217_C_G
##bone	Gene_EXP:LRRC4C	12_52771095_C_G
##bone	Gene_EXP:LUC7L	15_50544697_C_A,1_26457907_T_G,22_22643666_C_G,22_21127217_C_G,8_1678462_A_C
##bone	Gene_EXP:MAMLD1	4_42616004_T_TA,4_42616121_A_G
##bone	Gene_EXP:MAN2A2	18_112338_G_A
##bone	Gene_EXP:MAP2K1	22_21127217_C_G
##bone	Gene_EXP:MAP2K6	6_151015603_C_G
##bone	Gene_EXP:MAP3K3	5_23522263_C_T,12_128697174_A_G
##bone	Gene_EXP:MCF2	15_42142087_A_C
##bone	Gene_EXP:MCFD2	7_102356028_T_G
##bone	Gene_EXP:MCU	1_26457907_T_G
##bone	Gene_EXP:MDM4	17_6612211_T_C
##bone	Gene_EXP:MED23	15_42142087_A_C
##bone	Gene_EXP:MEIG1	5_141636680_A_C
##bone	Gene_EXP:MEIS1	11_1246619_A_C
##bone	Gene_EXP:MGLL	1_26457907_T_G,22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:MICAL2	6_151015603_C_G
##bone	Gene_EXP:MLC1	1_26457907_T_G,7_72941936_T_C
##bone	Gene_EXP:MOAP1	20_53576113_T_G
##bone	Gene_EXP:MRPS34	3_180647255_T_TA
##bone	Gene_EXP:MSRB3	3_52520584_A_C,22_37816755_A_G
##bone	Gene_EXP:MYH9	1_26457907_T_G,22_21127217_C_G
##bone	Gene_EXP:MYL9	1_26457907_T_G
##bone	Gene_EXP:MYOF	1_26457907_T_G,5_141432375_A_C
##bone	Gene_EXP:MYOM2	1_26457907_T_G
##bone	Gene_EXP:MYST3	14_95533353_T_A
##bone	Gene_EXP:NBAS	1_182843301_T_G,2_112783793_A_C
##bone	Gene_EXP:NCAPG2	6_146599135_C_T,17_40554659_A_G
##bone	Gene_EXP:NCEH1	6_151015603_C_G
##bone	Gene_EXP:NCKAP1L	1_26457907_T_G
##bone	Gene_EXP:NDST4	1_26457907_T_G,1_219210601_T_G
##bone	Gene_EXP:NELL2	1_26457907_T_G,5_141432375_A_C
##bone	Gene_EXP:NFE2L3	5_113434330_T_G,22_32394994_C_G,X_119791251_A_C
##bone	Gene_EXP:NINL	1_26457907_T_G,22_22643666_C_G
##bone	Gene_EXP:NOTCH2	22_21127217_C_G
##bone	Gene_EXP:NPW	1_26457907_T_G,3_52520584_A_C,15_69422319_A_C
##bone	Gene_EXP:NR0B1	1_26457907_T_G,22_21127217_C_G
##bone	Gene_EXP:NRP1	3_180647255_T_TA,15_68718780_C_T
##bone	Gene_EXP:NRTN	1_149813302_A_C
##bone	Gene_EXP:NSMF	7_45104514_C_T
##bone	Gene_EXP:NUCB2	16_19067773_T_G
##bone	Gene_EXP:NUDT10	1_26457907_T_G
##bone	Gene_EXP:NUDT16	1_26457907_T_G
##bone	Gene_EXP:NUP205	17_7604041_A_C
##bone	Gene_EXP:OLFM3	22_22643666_C_G
##bone	Gene_EXP:OLFML2B	8_21909794_T_G
##bone	Gene_EXP:ORAOV1	15_69422319_A_C
##bone	Gene_EXP:PALM3	22_22643666_C_G
##bone	Gene_EXP:PAPSS2	17_7388330_T_G
##bone	Gene_EXP:PAX7	1_26457907_T_G
##bone	Gene_EXP:PCDH17	1_26457907_T_G,5_141432375_A_C
##bone	Gene_EXP:PCDH8	12_52771095_C_G
##bone	Gene_EXP:PCMTD2	1_24336413_G_C,1_26457907_T_G
##bone	Gene_EXP:PDE6B	15_42142087_A_C
##bone	Gene_EXP:PDE9A	19_5654163_A_C,22_19918884_A_C
##bone	Gene_EXP:PDS5B	19_5654163_A_C
##bone	Gene_EXP:PDSS1	15_89633846_A_C,22_39376109_T_G
##bone	Gene_EXP:PENK	22_46668940_A_C
##bone	Gene_EXP:PFKFB4	2_48582490_G_T
##bone	Gene_EXP:PHLDA1	6_151015603_C_G
##bone	Gene_EXP:PLD6	22_21127217_C_G,22_21283300_G_C
##bone	Gene_EXP:PLIN3	10_92024747_C_T
##bone	Gene_EXP:PLK2	1_26457907_T_G
##bone	Gene_EXP:PLP2	16_24862746_A_C
##bone	Gene_EXP:PMP22	22_22117666_G_A,22_22117820_G_A
##bone	Gene_EXP:PNISR	15_42142087_A_C
##bone	Gene_EXP:PNMAL1	1_26457907_T_G
##bone	Gene_EXP:POU3F1	1_26457907_T_G,22_22643666_C_G
##bone	Gene_EXP:POU3F2	1_26457907_T_G,1_205381583_C_G,1_219210601_T_G,3_52520584_A_C,5_141432375_A_C
##bone	Gene_EXP:POU4F1	X_149503442_T_G
##bone	Gene_EXP:PPAPDC2	1_26457907_T_G,8_22080213_T_C,15_42142087_A_C,19_3179506_A_C,22_22643666_C_G
##bone	Gene_EXP:PPARD	15_25177023_G_C
##bone	Gene_EXP:PPFIBP1	3_180647255_T_TA
##bone	Gene_EXP:PPIB	12_31206191_C_T
##bone	Gene_EXP:PPP1R1A	1_26457907_T_G,5_141432375_A_C
##bone	Gene_EXP:PPP1R1B	1_109626825_A_C,6_53899709_T_G,7_99012221_A_C
##bone	Gene_EXP:PPP2R2A	9_39361570_C_A,13_20189082_A_C,12_52771095_C_G,1_26457907_T_G,3_126068075_T_G
##bone	Gene_EXP:PRDM15	1_26457907_T_G
##bone	Gene_EXP:PRKCA	14_39074610_T_TAAG
##bone	Gene_EXP:PRRX2	3_180647255_T_TA
##bone	Gene_EXP:PRSS35	1_26457907_T_G
##bone	Gene_EXP:PTBP2	15_59682341_T_A
##bone	Gene_EXP:PTGER2	20_49068783_G_C
##bone	Gene_EXP:PTGER3	1_26457907_T_G,1_219210601_T_G
##bone	Gene_EXP:PTGES3	1_26457907_T_G,1_149813302_A_C
##bone	Gene_EXP:PTPN13	1_26457907_T_G
##bone	Gene_EXP:PURG	5_141432375_A_C
##bone	Gene_EXP:QSER1	6_31464043_C_T
##bone	Gene_EXP:RAB32	1_26457907_T_G,5_141477711_A_G,15_92992967_C_T
##bone	Gene_EXP:RAI14	1_26457907_T_G
##bone	Gene_EXP:RAP1GAP	1_26457907_T_G
##bone	Gene_EXP:RAVER2	1_26457907_T_G
##bone	Gene_EXP:RBM11	1_26457907_T_G,19_624780_A_G,5_141432375_A_C,8_109483107_T_G,12_52771095_C_G
##bone	Gene_EXP:RBM11	1_26457907_T_G,19_624780_A_G,5_141432375_A_C,8_109483107_T_G,22_18847351_G_C
##bone	Gene_EXP:RBM11	1_26457907_T_G,5_141432375_A_C,19_624780_A_G,8_109483107_T_G,12_52771095_C_G
##bone	Gene_EXP:RBM12B	8_131984112_C_T
##bone	Gene_EXP:RBM27	19_48617887_T_G
##bone	Gene_EXP:RBM33	1_26457907_T_G
##bone	Gene_EXP:RBM39	1_26457907_T_G
##bone	Gene_EXP:RCAN1	22_22643666_C_G
##bone	Gene_EXP:RCOR1	1_176702776_TGAGAGAGA_T
##bone	Gene_EXP:RECQL	22_21127217_C_G
##bone	Gene_EXP:REEP5	1_26457907_T_G
##bone	Gene_EXP:RHBDD2	1_26457907_T_G,22_30937565_T_G
##bone	Gene_EXP:RHOC	1_26457907_T_G,5_141432375_A_C,22_22643666_C_G
##bone	Gene_EXP:RHOH	22_21127217_C_G
##bone	Gene_EXP:RND2	1_26457907_T_G
##bone	Gene_EXP:RPAIN	10_68691523_T_C
##bone	Gene_EXP:RPAP3	16_3027533_A_G
##bone	Gene_EXP:RPN1	1_26457907_T_G,5_141432375_A_C,22_22643666_C_G
##bone	Gene_EXP:RUNX1	1_26457907_T_G
##bone	Gene_EXP:SALL2	22_22643666_C_G
##bone	Gene_EXP:SBNO1	3_75668889_C_T,20_499958_CAA_C
##bone	Gene_EXP:SCNN1G	1_26457907_T_G
##bone	Gene_EXP:SDC1	1_26457907_T_G,3_52520584_A_C
##bone	Gene_EXP:SEC23A	1_26457907_T_G,5_141432375_A_C
##bone	Gene_EXP:SEPSECS	2_28529292_G_T
##bone	Gene_EXP:SERPING1	1_151048750_A_C,19_4930892_T_G
##bone	Gene_EXP:SFXN3	10_68691523_T_C
##bone	Gene_EXP:SH3GLB1	22_22643666_C_G
##bone	Gene_EXP:SHC2	19_54631904_A_C
##bone	Gene_EXP:SIAH3	1_26457907_T_G,15_69422319_A_C
##bone	Gene_EXP:SLAIN1	1_26457907_T_G,22_21127217_C_G
##bone	Gene_EXP:SLC10A3	4_87047646_A_T
##bone	Gene_EXP:SLC19A3	1_26457907_T_G
##bone	Gene_EXP:SLC24A3	22_22643666_C_G
##bone	Gene_EXP:SLC25A46	22_22643666_C_G
##bone	Gene_EXP:SLC35F1	1_26457907_T_G
##bone	Gene_EXP:SLC35F3	15_42142087_A_C
##bone	Gene_EXP:SLC5A6	1_184808038_A_C,X_46860063_C_T
##bone	Gene_EXP:SLCO5A1	1_26457907_T_G
##bone	Gene_EXP:SLITRK3	1_26457907_T_G,12_52771095_C_G
##bone	Gene_EXP:SNAI2	1_1657293_A_T,1_1657294_AGCG_A
##bone	Gene_EXP:SOX11	1_26457907_T_G,5_141432375_A_C,22_21127217_C_G
##bone	Gene_EXP:SPATA6L	1_26457907_T_G,8_1678462_A_C
##bone	Gene_EXP:SPOCD1	1_26457907_T_G
##bone	Gene_EXP:ST5	4_36107787_C_G,4_36147491_C_T
##bone	Gene_EXP:STMN3	6_110102054_T_G
##bone	Gene_EXP:STRBP	16_55810697_G_T,22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:SUCLG2	3_160423378_C_T
##bone	Gene_EXP:SYNC	15_42142087_A_C
##bone	Gene_EXP:SYNJ2	2_119366546_A_G
##bone	Gene_EXP:TADA1	3_180647255_T_TA
##bone	Gene_EXP:TCEAL3	1_214608652_G_A,5_33549454_C_A
##bone	Gene_EXP:TCF12	15_69422319_A_C
##bone	Gene_EXP:TEKT2	1_26457907_T_G
##bone	Gene_EXP:TFCP2	19_55796171_G_T
##bone	Gene_EXP:TGFB1I1	1_149813302_A_C
##bone	Gene_EXP:TGM2	19_2118693_C_T
##bone	Gene_EXP:TGS1	12_52771095_C_G
##bone	Gene_EXP:TMEM127	22_22643666_C_G,22_37816755_A_G
##bone	Gene_EXP:TMEM14C	6_31662464_C_T
##bone	Gene_EXP:TMEM170B	1_26457907_T_G
##bone	Gene_EXP:TMEM209	2_205740456_T_G
##bone	Gene_EXP:TMEM214	14_21019887_G_C
##bone	Gene_EXP:TMEM229A	22_22643666_C_G
##bone	Gene_EXP:TMEM70	1_26457907_T_G,10_35032524_A_C
##bone	Gene_EXP:TMEM81	19_7056560_G_T
##bone	Gene_EXP:TMEM9B	1_26457907_T_G,11_120298301_A_C
##bone	Gene_EXP:TNIP1	3_180647255_T_TA
##bone	Gene_EXP:TNKS	8_12359048_T_C
##bone	Gene_EXP:TOM1	1_20666326_G_C
##bone	Gene_EXP:TP53BP2	22_21127217_C_G
##bone	Gene_EXP:TP53I3	12_124966731_T_C
##bone	Gene_EXP:TRAM2	1_26457907_T_G,22_21127217_C_G
##bone	Gene_EXP:TRAPPC1	15_65451964_A_G,16_18896782_A_AAT
##bone	Gene_EXP:TRIM69	22_21127217_C_G
##bone	Gene_EXP:TRPM4	1_26457907_T_G,22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:TTC12	11_1246619_A_C
##bone	Gene_EXP:TXNDC15	7_90309274_C_G,12_121016539_T_A
##bone	Gene_EXP:UBXN7	1_26457907_T_G,22_24252424_G_C
##bone	Gene_EXP:UGT3A2	1_26457907_T_G
##bone	Gene_EXP:UHMK1	6_31464043_C_T,6_31710251_C_T
##bone	Gene_EXP:USP21	22_22643666_C_G
##bone	Gene_EXP:USP44	7_155711220_A_C,15_69422319_A_C
##bone	Gene_EXP:VANGL2	22_22643666_C_G
##bone	Gene_EXP:VAX1	1_26457907_T_G,22_21127217_C_G
##bone	Gene_EXP:VCL	5_141432375_A_C
##bone	Gene_EXP:VGLL1	2_33188942_T_A
##bone	Gene_EXP:VPS37D	7_72941936_T_C,1_26457907_T_G
##bone	Gene_EXP:WASF1	22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:WDR1	12_122976696_T_G
##bone	Gene_EXP:WDR41	2_217818534_A_G
##bone	Gene_EXP:WDR60	1_26457907_T_G
##bone	Gene_EXP:WIPI1	1_26457907_T_G
##bone	Gene_EXP:WNK2	1_26457907_T_G
##bone	Gene_EXP:WWOX	22_21127217_C_G
##bone	Gene_EXP:XG	1_26457907_T_G,22_21127217_C_G
##bone	Gene_EXP:XKR4	1_26457907_T_G,12_52771095_C_G,22_21127217_C_G
##bone	Gene_EXP:ZBTB34	6_151015603_C_G,11_1244522_A_C
##bone	Gene_EXP:ZCCHC5	22_22643666_C_G
##bone	Gene_EXP:ZDHHC17	1_26457907_T_G
##bone	Gene_EXP:ZNF232	5_141432375_A_C,6_32040790_G_C
##bone	Gene_EXP:ZNF335	1_26457907_T_G
##bone	Gene_EXP:ZNF397	1_26457907_T_G,15_56693096_A_C,22_21127217_C_G,22_22643666_C_G
##bone	Gene_EXP:ZNF467	5_157491842_C_T,17_78120770_A_C,22_21283300_G_C
##bone	Gene_EXP:ZNF607	12_56086744_A_C,12_121534367_T_A,17_42521150_A_C
##bone	Gene_EXP:ZNF703	10_71362188_T_C,15_42142087_A_C,19_3179506_A_C,22_22643666_C_G
##bone	Gene_EXP:ZNF786	1_26457907_T_G,16_25177910_T_G,17_7604041_A_C,17_78120770_A_C,22_30937565_T_G
##bone	Gene_EXP:ZNF862	1_26457907_T_G,22_22759034_G_A

[표 12]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value)를 산출한 결과가 아래 [표 13]에 정리되어있다.

또한, [표 12]에 제시된 FRH들이 포함되어 발현된 유전자들 중 주요 유전자와 각각의 bone(육종암) 약물과의 상관도(P-value)를 산출한 결과가 아래 [도 30]에 정리되어있다.

Correlation between gene expression and FRH

Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)	Gene	pvalue(FRH-Gene_exp)
LUC7L	1.15E-13	ADAM19	1.10E-07	KIAA0141	8.93E-07
TPM4	1.07E-11	PLK2	1.10E-07	KHK	9.12E-07
NUDT11	1.60E-11	LEAP2	1.11E-07	TMEM70	9.15E-07
PURG	4.30E-11	ZNF467	1.11E-07	MSI1	9.35E-07
TUBB2B	4.81E-11	APOL3	1.13E-07	IL11	9.36E-07
TGFBR2	5.51E-11	KDELR3	1.14E-07	GFRA2	9.37E-07
RHOC	5.76E-11	PCDH17	1.14E-07	EFNA3	9.38E-07
ST6GAL1	7.69E-11	CFL2	1.15E-07	SLC25A43	9.39E-07
KLHL23	8.77E-11	EXT2	1.15E-07	ABAT	9.48E-07
FUCA2	9.85E-11	LPAR2	1.16E-07	NAGA	9.50E-07
NINL	9.85E-11	KDSR	1.17E-07	MT2A	9.53E-07
MGLL	1.10E-10	ATP2B3	1.18E-07	NGF	9.67E-07
NKX2-2	1.20E-10	TMEM14C	1.20E-07	PCP4	9.72E-07
ARHGAP10	1.29E-10	TTC12	1.21E-07	COPG	9.86E-07
DPP9	1.58E-10	JHDM1D	1.21E-07	TXNDC11	9.96E-07
RBM11	1.92E-10	CORO1C	1.22E-07	SRSF6	9.97E-07
ACTN1	1.95E-10	CDK13	1.23E-07	SPAST	9.98E-07
FCGRT	2.01E-10	FNDC3B	1.23E-07	CPD	1.02E-06
JAKMIP2	2.32E-10	TCIRG1	1.24E-07	ZNF250	1.02E-06
GYG1	2.51E-10	ATP11C	1.24E-07	NPW	1.03E-06
FAM19A5	2.59E-10	PPIL6	1.26E-07	ADNP	1.03E-06
EPHA4	2.73E-10	WASF1	1.26E-07	CACNA1H	1.03E-06
MYH9	4.61E-10	CCDC59	1.27E-07	ITGAE	1.03E-06
ZNF397	4.81E-10	FNBP1	1.29E-07	PKP1	1.03E-06
TMEM9B	4.87E-10	MAP4K5	1.30E-07	PTPN21	1.04E-06
MYOF	4.88E-10	OSCP1	1.33E-07	IRF1	1.04E-06
ARID2	4.89E-10	ATP5G2	1.34E-07	SRPRB	1.05E-06
CLSTN2	5.02E-10	LACTB	1.35E-07	AGT	1.05E-06
NOTCH2	5.05E-10	OSTF1	1.35E-07	ZC3HC1	1.05E-06
ASGR1	5.14E-10	CCDC23	1.39E-07	COL6A1	1.06E-06
PPP1R1A	5.38E-10	FAM124A	1.41E-07	ADAMTS6	1.08E-06
ACVR1B	5.88E-10	NPTXR	1.41E-07	SNAPC4	1.08E-06
EEA1	5.97E-10	ANXA11	1.42E-07	ZNF709	1.08E-06
ACTN2	6.01E-10	MYCN	1.44E-07	PBRM1	1.09E-06
GPC2	6.03E-10	STK35	1.44E-07	PHF14	1.10E-06
NKX6-1	6.10E-10	ZNF74	1.47E-07	TP53BP2	1.10E-06
FANCF	6.17E-10	SV2B	1.48E-07	PCMTD2	1.11E-06
SOX11	6.17E-10	PPAPDC2	1.48E-07	IGSF9	1.12E-06
VANGL2	6.29E-10	ARL6IP5	1.49E-07	PAPSS1	1.12E-06
TEAD2	7.31E-10	PRKCE	1.49E-07	CDC42EP3	1.14E-06
TNIP1	8.84E-10	DPYSL2	1.52E-07	ESYT2	1.14E-06
SPATA6L	9.42E-10	CTSA	1.53E-07	CD83	1.15E-06
LRP10	9.62E-10	NUDT16	1.54E-07	ASRGL1	1.16E-06
MYL6B	9.88E-10	MYL9	1.54E-07	PLCH1	1.17E-06
ZNF703	9.89E-10	DST	1.55E-07	HIVEP2	1.18E-06
PPARD	1.06E-09	ARHGAP19	1.59E-07	GCHFR	1.19E-06
CNOT6	1.29E-09	PLD6	1.61E-07	VASP	1.19E-06
LMO2	1.32E-09	PDIK1L	1.61E-07	ZNF253	1.19E-06
DPYSL5	1.37E-09	FOXC1	1.61E-07	ARHGAP1	1.19E-06
LGALS1	1.81E-09	NR0B1	1.63E-07	CYP2J2	1.20E-06
FUT11	1.90E-09	ARHGAP5	1.64E-07	CADM4	1.21E-06
CRMP1	1.99E-09	FAM84B	1.65E-07	CPB2	1.22E-06
OLFM3	2.12E-09	SS18L1	1.67E-07	SP100	1.23E-06
HMCN1	2.13E-09	BMP4	1.69E-07	STEAP2	1.23E-06
IL13RA1	2.24E-09	ADRB1	1.69E-07	ZNF142	1.24E-06
KIAA1456	2.30E-09	ITM2A	1.76E-07	ATG3	1.24E-06
PALM3	2.42E-09	TGOLN2	1.81E-07	BRD1	1.26E-06
STRBP	2.46E-09	CCDC74A	1.82E-07	RPS27L	1.26E-06
ID2	2.49E-09	RECQL	1.83E-07	TRIM8	1.26E-06
CSRP2BP	2.49E-09	KRT25	1.85E-07	FNBP1L	1.27E-06
DLG2	2.53E-09	SHC2	1.89E-07	PDE6B	1.27E-06
WIPI1	2.66E-09	SLCO5A1	1.90E-07	SLC25A46	1.28E-06
LIPI	2.74E-09	DNASE1L1	1.91E-07	SH3GLB1	1.29E-06
BCL11B	2.86E-09	GPR155	1.91E-07	RHOA	1.30E-06
SLC24A3	2.90E-09	PTGES3	1.93E-07	SH3YL1	1.31E-06
FAM114A1	3.02E-09	CNN3	1.94E-07	RABGAP1	1.34E-06
SHANK3	3.09E-09	FOSL2	1.96E-07	PTGER3	1.35E-06
THAP9	3.13E-09	HAND2	1.97E-07	NAA25	1.36E-06
ERO1L	3.14E-09	PLIN3	2.06E-07	SMAD9	1.37E-06
SLAIN1	3.34E-09	BDKRB1	2.07E-07	ROM1	1.37E-06
UBTD1	3.56E-09	SDC1	2.10E-07	CD44	1.38E-06
RAB7A	3.57E-09	NPY1R	2.16E-07	MBD6	1.39E-06
CCDC74B	3.60E-09	PTRF	2.17E-07	RHOG	1.41E-06
TEKT2	3.64E-09	CCSER2	2.19E-07	RASA3	1.41E-06
ERC2	3.75E-09	BDNF	2.21E-07	CAPRIN1	1.43E-06
ELOVL1	3.82E-09	LRRC4B	2.24E-07	GPR135	1.43E-06
TMEM206	4.01E-09	SLFN11	2.26E-07	KIT	1.44E-06
SWT1	4.09E-09	TMEM68	2.27E-07	TADA1	1.45E-06
EZH2	4.21E-09	EPC1	2.27E-07	TBC1D2	1.46E-06
UBE2G2	4.66E-09	CAP1	2.28E-07	GSTA4	1.47E-06
HEATR5A	4.70E-09	DDHD2	2.30E-07	TMPO	1.48E-06
BHLHE22	4.82E-09	TMEM214	2.31E-07	CLIP1	1.48E-06
DHX57	5.00E-09	03-Sep	2.33E-07	PRPS2	1.48E-06
IVNS1ABP	5.01E-09	PCDH8	2.34E-07	DRAP1	1.48E-06
PNMA2	5.01E-09	SH3D19	2.41E-07	BCL7A	1.50E-06
CRTAP	5.13E-09	RAI14	2.41E-07	KIAA1958	1.50E-06
C1orf27	5.14E-09	CACHD1	2.43E-07	CSRNP3	1.52E-06
EVI2A	5.23E-09	PPIC	2.45E-07	TRAPPC9	1.55E-06
GBE1	5.25E-09	RPAP3	2.49E-07	SIAH3	1.56E-06
WWTR1	5.44E-09	BTG2	2.49E-07	NME4	1.57E-06
ANKRD28	5.48E-09	RASGEF1B	2.52E-07	CCDC85B	1.57E-06
LONRF1	5.51E-09	E2F6	2.52E-07	CCDC80	1.57E-06
IRS2	5.52E-09	EFCAB7	2.54E-07	BTBD17	1.57E-06
PRSS35	5.61E-09	SLC35F1	2.58E-07	LMNA	1.57E-06
LEPROTL1	5.62E-09	NYNRIN	2.60E-07	FUT8	1.58E-06
NELL2	5.72E-09	SLITRK3	2.63E-07	DNAJC12	1.59E-06
XKR4	5.75E-09	GRP	2.63E-07	SPOCD1	1.60E-06
NCKAP1L	5.85E-09	STMN3	2.63E-07	ZNF862	1.60E-06
ZNF84	6.22E-09	PDE3B	2.68E-07	CARD10	1.60E-06
ZNF232	6.23E-09	ZNF740	2.72E-07	AP3S1	1.63E-06
PPP2R2A	6.49E-09	SEC11C	2.74E-07	TP53I3	1.65E-06
BRF2	6.92E-09	FAM120A	2.77E-07	NDUFC1	1.66E-06
RPN1	7.16E-09	B4GALT4	2.78E-07	CRABP1	1.66E-06
SAMD4A	7.16E-09	FAM69A	2.82E-07	RAB31	1.66E-06
EPB41	7.17E-09	ZNF219	2.84E-07	RNF44	1.67E-06
HS3ST3B1	7.33E-09	ZNF607	2.91E-07	TBC1D23	1.68E-06
POU3F2	7.57E-09	RBMX	2.92E-07	PLCXD1	1.69E-06
S100A13	7.61E-09	LPHN1	2.94E-07	HOOK1	1.69E-06
FBXO15	7.64E-09	SEC61A1	2.95E-07	CRYBG3	1.69E-06
PNMAL1	7.74E-09	AKAP7	2.96E-07	PRIMA1	1.71E-06
SEC23A	7.94E-09	TRIM47	2.96E-07	PBX1	1.71E-06
LRRC4C	8.57E-09	C2CD4C	2.96E-07	ELOVL4	1.71E-06
CPED1	8.66E-09	SMARCC1	2.97E-07	SPAG1	1.72E-06
TRPM4	8.83E-09	RBM33	3.03E-07	RRBP1	1.72E-06
SYNC	8.87E-09	UBXN7	3.05E-07	CEP19	1.72E-06
PDE9A	9.07E-09	BHLHE40	3.08E-07	GSN	1.74E-06
ACOT9	9.27E-09	MYST3	3.10E-07	PPFIBP1	1.76E-06
CHPF	9.30E-09	NEIL1	3.10E-07	MAST1	1.78E-06
GALNT10	9.85E-09	FAM69B	3.12E-07	TRIM69	1.78E-06
CTSL1	1.02E-08	RNF182	3.13E-07	OSBPL3	1.79E-06
AIG1	1.05E-08	CREBBP	3.13E-07	SPEN	1.80E-06
NDST4	1.06E-08	TGS1	3.14E-07	RBBP5	1.81E-06
SRSF12	1.10E-08	DDX51	3.18E-07	RBM12B	1.81E-06
BAHCC1	1.23E-08	CELSR2	3.20E-07	PIGK	1.83E-06
BCL10	1.32E-08	IL1R1	3.21E-07	COL6A2	1.83E-06
MFSD1	1.33E-08	ADAM12	3.22E-07	TXNL4A	1.84E-06
MYOM2	1.42E-08	E2F5	3.22E-07	RNF181	1.84E-06
DTX3L	1.42E-08	CXCR4	3.30E-07	CD163L1	1.87E-06
PLOD1	1.44E-08	CHD6	3.34E-07	PHF2	1.89E-06
H2AFY2	1.47E-08	PPIB	3.34E-07	GPC1	1.90E-06
PLAGL2	1.51E-08	CHD3	3.40E-07	LMO3	1.90E-06
KBTBD11	1.52E-08	CYLD	3.47E-07	GABBR1	1.92E-06
GLB1L2	1.54E-08	CREB3L1	3.52E-07	KCNMA1	1.93E-06
CYR61	1.57E-08	RFTN1	3.54E-07	ERLEC1	1.93E-06
MGAT2	1.59E-08	ATAT1	3.56E-07	B4GALT7	1.93E-06
XG	1.60E-08	N4BP2	3.60E-07	HNRNPH3	1.94E-06
CMTM7	1.67E-08	RAP1GAP	3.61E-07	PLEKHF1	1.94E-06
DNAJC15	1.70E-08	YBX2	3.62E-07	HNRNPA1L2	1.95E-06
PIK3CB	1.72E-08	EOGT	3.65E-07	TLN1	1.98E-06
CDS1	1.75E-08	POU6F1	3.67E-07	TCEAL3	2.00E-06
IQGAP1	1.78E-08	ZSCAN2	3.70E-07	HK1	2.00E-06
TMEM127	1.79E-08	MYEF2	3.74E-07	ZNF335	2.00E-06
TPTE2	1.83E-08	CLTB	3.77E-07	MME	2.01E-06
SALL2	1.88E-08	PGLYRP2	3.79E-07	ANKRD37	2.02E-06
ENPP3	1.94E-08	RHBDD2	3.81E-07	GDF6	2.04E-06
IGF2BP1	1.97E-08	NRP1	3.83E-07	ZBTB16	2.05E-06
KAT2B	2.01E-08	COX19	3.85E-07	SYNM	2.06E-06
KLF4	2.03E-08	AKT1	3.94E-07	STX5	2.06E-06
VAX1	2.05E-08	ZNF124	3.96E-07	CA12	2.09E-06
MARCKSL1	2.07E-08	SPHK1	3.99E-07	SNAI2	2.10E-06
USP21	2.14E-08	KLRAP1	4.06E-07	DDX31	2.10E-06
EGFLAM	2.21E-08	SPRYD7	4.10E-07	EFNB1	2.11E-06
SUCLG2	2.28E-08	KANSL2	4.10E-07	GATA6	2.12E-06
FAH	2.31E-08	TANC2	4.10E-07	KDM4A	2.13E-06
MAP2K1	2.36E-08	CYBA	4.16E-07	EFS	2.14E-06
GLT25D1	2.42E-08	HEG1	4.17E-07	TMEM38A	2.15E-06
GCNT1	2.45E-08	CDKL3	4.19E-07	SET	2.16E-06
TMEM79	2.48E-08	ITPRIPL2	4.23E-07	GAS1	2.19E-06
ZSCAN21	2.52E-08	S100A6	4.30E-07	TLE4	2.20E-06
ITFG2	2.52E-08	MCF2	4.31E-07	FAM174A	2.20E-06
UGT3A2	2.56E-08	CCNJ	4.40E-07	BTD	2.22E-06
SECISBP2	2.59E-08	SLC26A10	4.43E-07	FGF11	2.23E-06
PLOD2	2.72E-08	TLE2	4.47E-07	OSBPL10	2.26E-06
RAB32	2.72E-08	SCNN1G	4.49E-07	ELAVL3	2.28E-06
PMP22	2.76E-08	OAT	4.52E-07	GBF1	2.30E-06
OTUD3	2.79E-08	SGMS2	4.52E-07	PRTG	2.34E-06
MLC1	2.89E-08	TMEM81	4.54E-07	SEPP1	2.34E-06
TRAM2	2.99E-08	ICAM3	4.56E-07	CTSZ	2.38E-06
PAX7	3.04E-08	TXNDC15	4.59E-07	CD55	2.40E-06
ZDHHC17	3.22E-08	SOX6	4.59E-07	CCK	2.41E-06
ITGB1	3.28E-08	RUNX1	4.61E-07	RBMS3	2.41E-06
EGFL7	3.28E-08	CHN2	4.68E-07	CD63	2.41E-06
HEXB	3.29E-08	SLC35B2	4.82E-07	HIPK1	2.42E-06
DGKD	3.35E-08	IL4R	4.83E-07	B4GALNT4	2.43E-06
ALG6	3.42E-08	ADAM9	4.83E-07	AGPHD1	2.43E-06
CUX2	3.45E-08	ACTN4	4.94E-07	MAZ	2.47E-06
TCF3	3.47E-08	RALGAPA2	4.98E-07	FOSL1	2.48E-06
RIMS3	3.51E-08	GM2A	4.99E-07	CD68	2.52E-06
VCL	3.53E-08	DKK2	5.00E-07	HSDL1	2.53E-06
POU3F1	3.55E-08	FLAD1	5.08E-07	CSPG5	2.53E-06
PARD6B	3.64E-08	NRP2	5.09E-07	RBM39	2.54E-06
FEZF1	3.65E-08	PRRT2	5.10E-07	ATN1	2.55E-06
PHACTR2	3.73E-08	PARVA	5.16E-07	PDLIM1	2.55E-06
RND2	3.80E-08	ARX	5.19E-07	RNF2	2.56E-06
IGFBP2	3.87E-08	ZNF704	5.20E-07	SLC35F5	2.56E-06
DLGAP1	3.88E-08	SAMD9L	5.22E-07	PLSCR1	2.56E-06
ADRB3	3.94E-08	GRIK5	5.23E-07	GAL3ST3	2.58E-06
FRMD6	4.15E-08	CPVL	5.30E-07	AXL	2.58E-06
GOLIM4	4.16E-08	SOHLH2	5.32E-07	SYT1	2.58E-06
CBX2	4.22E-08	TTLL6	5.33E-07	HMGB3	2.59E-06
MEIS1	4.33E-08	PROCA1	5.41E-07	PER3	2.63E-06
ABHD6	4.44E-08	SLC2A10	5.43E-07	ZNF271	2.63E-06
ATOX1	4.45E-08	KIF1A	5.44E-07	CYTH3	2.63E-06
EHD2	4.47E-08	PPAP2B	5.44E-07	CDH23	2.65E-06
C1QTNF3	4.47E-08	IKBIP	5.47E-07	TMEM184B	2.66E-06
RIN1	4.49E-08	C9orf89	5.52E-07	PPP2R3A	2.67E-06
LGALS3	4.62E-08	ACVR2B	5.53E-07	PCSK1N	2.67E-06
RAVER2	4.66E-08	ENC1	5.58E-07	RBBP6	2.71E-06
CREB3L2	4.70E-08	ENDOD1	5.64E-07	ZNF532	2.71E-06
BCAR3	4.70E-08	MOB1A	5.64E-07	DNAJB12	2.73E-06
ZNF589	4.72E-08	SPTBN1	5.65E-07	SCP2	2.73E-06
ZNF345	4.73E-08	USP31	5.66E-07	UPF3B	2.74E-06
ACACB	4.82E-08	RPAIN	5.71E-07	GPR180	2.75E-06
HS3ST4	4.84E-08	UCHL1	5.74E-07	QSOX1	2.76E-06
EFHD2	4.89E-08	CSAD	5.75E-07	SPATS2L	2.76E-06
05-Sep	4.89E-08	TNFRSF12A	5.87E-07	ZFP62	2.78E-06
ICAM4	4.91E-08	THBS1	5.89E-07	FKBP4	2.79E-06
TMED1	4.99E-08	DUSP26	5.90E-07	SEMA5A	2.80E-06
UBE2I	5.07E-08	MFAP4	5.93E-07	WNK2	2.80E-06
LINGO1	5.31E-08	TMEM98	5.93E-07	CLIC1	2.81E-06
BCAP29	5.50E-08	GOLGB1	5.95E-07	PDE7A	2.82E-06
FAM117B	5.51E-08	MREG	6.00E-07	SCN4B	2.82E-06
NUDT10	5.56E-08	FREM1	6.01E-07	WIPF1	2.83E-06
WWOX	5.61E-08	C1GALT1	6.01E-07	SP140L	2.83E-06
PTPN13	5.72E-08	PPFIA3	6.04E-07	ART3	2.85E-06
MICAL2	5.73E-08	TMX1	6.07E-07	ZBTB39	2.85E-06
SYTL2	5.73E-08	RSU1	6.08E-07	HDAC2	2.90E-06
ACP1	5.75E-08	MAN1A1	6.09E-07	RTN4	2.91E-06
LAMC1	5.78E-08	CALR	6.19E-07	GIPC1	2.91E-06
GADD45B	6.04E-08	CAST	6.27E-07	ZMIZ1	2.92E-06
RCAN1	6.14E-08	THEM4	6.29E-07	MAFF	2.94E-06
LPP	6.18E-08	FGF5	6.32E-07	COQ7	2.97E-06
CD59	6.35E-08	MCU	6.50E-07	L3MBTL3	3.02E-06
MBNL1	6.42E-08	EHBP1	6.54E-07	IQGAP2	3.03E-06
CTGF	6.43E-08	AVPI1	6.56E-07	CYP4F22	3.04E-06
TCP10L	6.47E-08	HOXC13	6.64E-07	CALD1	3.05E-06
OLFM1	6.50E-08	SMARCD1	6.72E-07	RGL1	3.07E-06
NKAIN2	6.51E-08	BAZ2A	6.74E-07	CAMSAP3	3.10E-06
SERPINB1	6.55E-08	ELL2	6.82E-07	GMPPA	3.13E-06
NLGN4X	6.66E-08	NMNAT3	6.91E-07	ARHGAP22	3.17E-06
HR	6.67E-08	ZNF3	6.92E-07	ABTB1	3.17E-06
FAIM	6.79E-08	SLC41A2	6.94E-07	PRR4	3.17E-06
DOC2A	7.17E-08	SQSTM1	6.99E-07	FAM49A	3.22E-06
KLHL8	7.20E-08	MCL1	7.03E-07	SAFB	3.22E-06
FZD3	7.21E-08	ZNF684	7.10E-07	LNPEP	3.23E-06
AMOTL2	7.24E-08	AHNAK2	7.21E-07	ZXDC	3.27E-06
TMEM170B	7.28E-08	SH3RF1	7.25E-07	DKK3	3.32E-06
C11orf24	7.28E-08	MGAT1	7.25E-07	SEC11A	3.34E-06
DNMT3A	7.56E-08	UGGT2	7.36E-07	IL6ST	3.38E-06
HOXB13	7.66E-08	WDR67	7.47E-07	GPR123	3.40E-06
C1orf114	7.80E-08	MSRB3	7.48E-07	NAPB	3.42E-06
CIB1	7.88E-08	IFT81	7.52E-07	MAB21L3	3.48E-06
MEIG1	7.92E-08	PICALM	7.65E-07	SUMF1	3.51E-06
PDSS1	7.95E-08	TOR1AIP1	7.70E-07	ZFHX2	3.54E-06
ACTR6	8.05E-08	WNK3	7.73E-07	IFIT1	3.55E-06
GRTP1	8.09E-08	MDM4	7.82E-07	ALS2CR8	3.57E-06
ITGA3	8.13E-08	TTC7A	7.85E-07	PTPRR	3.57E-06
SGMS1	8.33E-08	AP4B1	7.86E-07	HRSP12	3.59E-06
SFXN3	8.51E-08	PDS5B	7.88E-07	MBNL2	3.62E-06
VIM	8.54E-08	TMEM158	7.99E-07	PDIA3	3.63E-06
FAM19A2	8.67E-08	PAPSS2	8.00E-07	C22orf15	3.63E-06
NAALAD2	8.77E-08	S100A2	8.03E-07	GPX8	3.65E-06
SLC5A6	8.78E-08	ADRA1D	8.06E-07	BAG3	3.70E-06
TPM1	8.79E-08	CAD	8.09E-07	SPTLC3	3.71E-06
HPCAL1	8.91E-08	PRRT4	8.11E-07	THOC1	3.71E-06
JPH1	9.08E-08	GNG12	8.12E-07	WDR1	3.71E-06
PRDM15	9.10E-08	PRDX2	8.12E-07	ZNF711	3.74E-06
REEP5	9.36E-08	PFKM	8.13E-07	ARF6	3.75E-06
PAFAH1B3	9.50E-08	SYNJ2	8.14E-07	SLC19A3	3.78E-06
LHFPL2	9.61E-08	ZNF786	8.26E-07	RPP25	3.79E-06
TREX1	9.92E-08	TSPAN13	8.31E-07
ATP1A1	9.97E-08	APOE	8.35E-07
SHF	1.01E-07	DCBLD1	8.37E-07
KMO	1.04E-07	ZNF48	8.44E-07
HTRA1	1.08E-07	CENPV	8.46E-07
RHOH	1.08E-07	AHNAK	8.56E-07
PRAC	1.08E-07	C4orf29	8.69E-07
PARM1	1.09E-07	MERTK	8.71E-07
LRRFIP2	1.09E-07	GDF11	8.90E-07
PEA15	1.10E-07	NEUROD6	8.93E-07

이들 [표 13] 및 [도 30]으로부터 [표 13] 및 [도 30]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 육종암 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

다음으로, 본 발명에서 기능하플로타입을 이용한 GBLscan을 통하여 산출된, 각 약물타입 별로 약물에 대한 반응성에 영향을 미치는 바이오마커에 대하여 설명한다.

구체적으로, 약물타입(Drug Class)의 구분 별로, ABL의 바이오 마커 158개(표 15참조), CHROMATIN의 바이오 마커 438개(표 17참조), EGFR의 바이오 마커 197개(표 19참조), ERK_MAPK의 바이오 마커 673개(표 21참조), IGFR의 바이오 마커 159개(표 23참조), MITOSIS의 바이오 마커 202개(표 25참조)이다.

아래 [표 15] 내지 [표 25]에는 약물타입 별로 본 발명에 의해 발굴된 바이오 마커가 표시되어 있다. 여기서 바이오 마커의 형태 및 표현 방식은 전술한 암종류별로 구분된 바이오 마커와 동일하다.

특정 pathway & signaling를 표적으로 하는 약물타입(DrugClass) 정의

구분	DrugClass	Drugs	Pathway & signaling(Target gene & function)
1	ABL	Imatinib, GNF-2, Dasatinib, Saracatinib, WH-4-023, Bosutinib, Ponatinib, HG-5-113-01, Nilotinib	ABL, SRC, KIT, PDGFR, ABL1,TEC, LOK, LTK, TRCB,
2	CHROMATIN	Phenformin, AICA_Ribonucleotide, Daporinad	HDAC, RAR, HDAC inhibitor Class I, IIa, IIb, IV; HDAC6, EGFR, G9a(EHMT2), GLP(EHMT1), Q8TEK3 (DOT1L), BRD2, BRD3, BRD4
3	EGFR	Gefitinib, Erlotinib, Cetuiximab, Lapatinib, Afatinib, HG-5-88-01, CP724714, Pelitinib	ERBB2, EGFR, ADCK4
4	ERK_MAPK	Dabrafenib, VX-11e, AZ628, Selumetinib, CI-1040, PD0325901, Selumetinib, Refametinib, Trametinib, TL-2-105, HG6-64-1, PLX-4720, SB590885, SL0101, CMK, FMK, FR=180204	MAP2K1 (MEK1), MAP2K2 (MEK2), BRAF, ERK, RSK, AURKB, PIM3, CRAF, BRAFV600E, TAK, MAP4K5
5	IGFR	CSK1904529A, BMS-536924, BMS-754807, Linsitinib	IGF1R
6	MITOSIS	Dacinostat, JQ1, SGC0946, VNLG/124, UNC0638, Belinostat, CUDC-101, Vorinostat, CAY10603, AR-42, I-BET-762, Tubastatin A, PFI-1, Entinostat, JQ12	AURKB, MPS1, KIF11, AURKA, PLK3, AURKC, FLT3, ABL1, JAK2, PLK3

ABL 약물에 대한 반응성 바이오 마커

Drug_Class	Gene_exp	바이오마커 ( 발현조절변이세트 )
abl	Gene_EXP:ABHD3	17_68269074_G_C
abl	Gene_EXP:ACSF2	2_71393433_A_G,2_71424561_G_GT,2_71428456_T_A,2_71433365_T_TC
abl	Gene_EXP:ACVR1B	2_113934259_C_T,5_181155466_T_G,10_79312556_A_G,11_12162199_T_G,12_6818898_A_C
abl	Gene_EXP:ADAR	1_152312661_G_T,2_55588861_T_C,3_56753664_A_G,22_41781812_C_A
abl	Gene_EXP:ADAT2	5_141490949_A_G,17_41827392_A_C
abl	Gene_EXP:ALDH5A1	2_100470432_G_A,2_100470504_C_T,2_100470642_C_T,2_178612907_A_C
abl	Gene_EXP:ARL17B	7_87391707_G_C
abl	Gene_EXP:ARRB1	16_46710765_T_A
abl	Gene_EXP:ASH2L	9_33796659_C_T,9_33796705_C_G,9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
abl	Gene_EXP:ATP6V0B	17_78529723_C_G
abl	Gene_EXP:ATP7B	2_182063828_G_C,5_176336593_G_A,5_176347862_G_T
abl	Gene_EXP:BAI3	6_30705792_T_G,13_113159942_A_G
abl	Gene_EXP:BDKRB1	22_22643666_C_G
abl	Gene_EXP:BLCAP	4_48609132_A_G
abl	Gene_EXP:C15orf26	17_999610_T_C
abl	Gene_EXP:C1R	13_113159942_A_G
abl	Gene_EXP:CAMK2D	2_100964113_G_A,2_100977729_C_T,11_45181661_C_T
abl	Gene_EXP:CASP1	12_40313960_G_T
abl	Gene_EXP:CAV1	10_133626829_C_T
abl	Gene_EXP:CCRL2	15_82477660_C_A
abl	Gene_EXP:CD97	4_8036186_A_G,5_141193109_A_G,7_108514148_A_C,12_108517007_T_G,17_80137479_A_T
abl	Gene_EXP:CEP57L1	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T,9_33798019_A_G
abl	Gene_EXP:CHGB	15_67236036_T_G
abl	Gene_EXP:CMBL	11_117203393_G_A
abl	Gene_EXP:CRADD	8_123427934_A_G,8_123429947_A_G,8_123436496_A_G,8_123436564_T_A,8_123437226_C_T
abl	Gene_EXP:CRB3	15_98922244_C_T
abl	Gene_EXP:CST3	5_181155466_T_G,10_11921140_T_G
abl	Gene_EXP:CUX2	22_21127217_C_G
abl	Gene_EXP:CXXC1	2_119254595_G_A,3_112199369_A_G
abl	Gene_EXP:CYTH3	2_66439901_A_C
abl	Gene_EXP:DBH	13_113159942_A_G
abl	Gene_EXP:DCBLD1	10_26746549_C_T,11_12162199_T_G
abl	Gene_EXP:DGAT1	3_38905381_A_T,3_38910262_T_C,11_18484005_G_A
abl	Gene_EXP:DLC1	2_182063828_G_C,20_56366031_C_T
abl	Gene_EXP:DQX1	1_113907966_C_T
abl	Gene_EXP:DSTN	1_214608652_G_A,16_24750598_A_G,16_24806184_C_T
abl	Gene_EXP:EDIL3	11_12162199_T_G
abl	Gene_EXP:EFEMP1	1_248441636_T_G,7_149253814_T_G
abl	Gene_EXP:EFHD2	1_451649_A_AG,1_213007133_T_G,2_61492168_C_A,12_51745916_T_G
abl	Gene_EXP:ELOVL5	13_37746457_TAA_TA
abl	Gene_EXP:ENG	3_186558604_C_T,22_29806785_G_C
abl	Gene_EXP:EVPL	15_84798628_G_A
abl	Gene_EXP:FAM126A	1_451649_A_AG,7_72942379_A_C
abl	Gene_EXP:FAM163A	2_113934259_C_T,6_33279455_T_G,16_30953637_A_C,20_16044565_T_G
abl	Gene_EXP:FHL3	11_65543121_A_C
abl	Gene_EXP:FLNA	20_34750204_T_G,10_79312556_A_G,15_84241166_A_C,16_1817242_T_C,3_100302035_G_T
abl	Gene_EXP:FLNA	3_118902653_C_T
abl	Gene_EXP:G6PD	16_87644643_G_A
abl	Gene_EXP:GAB2	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
abl	Gene_EXP:GAB2	1_451649_A_AG
abl	Gene_EXP:GATA2	2_182063828_G_C
abl	Gene_EXP:GBE1	8_122952205_T_G,14_93183653_A_C,5_181155466_T_G,19_47441156_T_G,19_9566733_T_G
abl	Gene_EXP:GBP1	11_12162199_T_G
abl	Gene_EXP:GBP1	3_55480738_A_T
abl	Gene_EXP:GLUL	16_46710765_T_A
abl	Gene_EXP:GMPR	2_182063828_G_C
abl	Gene_EXP:GRB10	7_51028450_A_G,12_56425138_C_T
abl	Gene_EXP:HLF	19_54338327_C_T
abl	Gene_EXP:HNRPDL	17_55774876_T_G
abl	Gene_EXP:HSPG2	1_37703244_A_C,15_84241166_A_C
abl	Gene_EXP:ICA1	1_451649_A_AG
abl	Gene_EXP:ICAM1	8_12358868_A_G
abl	Gene_EXP:IFNAR1	16_259458_T_G,1_154331414_T_G,1_64663808_A_C,18_14183954_G_T,7_32543154_A_C
abl	Gene_EXP:IL15RA	22_36566306_C_G
abl	Gene_EXP:IRX5	1_13248174_T_C
abl	Gene_EXP:KAT7	16_16036657_C_A
abl	Gene_EXP:KDSR	22_21127217_C_G
abl	Gene_EXP:KHDRBS1	19_11431113_CT_C
abl	Gene_EXP:KLF15	8_7259511_T_C,10_50311228_T_G
abl	Gene_EXP:KLHL23	10_79312556_A_G,13_113159942_A_G,13_113325635_A_G
abl	Gene_EXP:KMO	22_21127217_C_G
abl	Gene_EXP:LAPTM4B	20_56366031_C_T
abl	Gene_EXP:LEPROTL1	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T,9_33798019_A_G
abl	Gene_EXP:LIN28B	2_113934259_C_T,5_181155466_T_G,8_7290003_A_C
abl	Gene_EXP:LPP	18_909560_A_G,14_93183653_A_C,11_73355795_A_G,1_15381304_A_C,6_31966660_T_G
abl	Gene_EXP:LRP11	9_108900415_C_A
abl	Gene_EXP:LSM7	13_113159942_A_G
abl	Gene_EXP:MANBAL	1_24074187_A_G
abl	Gene_EXP:MICALL2	7_72942379_A_C,8_7290003_A_C,11_12162199_T_G,12_51745916_T_G,16_30953637_A_C
abl	Gene_EXP:MMP14	15_99729430_G_C
abl	Gene_EXP:MPP1	7_114663562_CT_C,9_33796659_C_T,9_33798019_A_G
abl	Gene_EXP:MTPAP	3_49714047_T_G
abl	Gene_EXP:MYH9	1_15381304_A_C,9_69516199_A_C,10_11921140_T_G,13_113159942_A_G
abl	Gene_EXP:MYH9	22_36566306_C_G
abl	Gene_EXP:NAALADL2	1_78893077_T_G
abl	Gene_EXP:NFE2	2_182063828_G_C
abl	Gene_EXP:NFKBIA	10_43616797_G_A
abl	Gene_EXP:NNMT	11_12162199_T_G,13_113325635_A_G
abl	Gene_EXP:NUCB2	8_26370124_A_G
abl	Gene_EXP:NUDC	18_24064127_G_T
abl	Gene_EXP:NUDT3	11_119054629_G_A
abl	Gene_EXP:NUP43	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
abl	Gene_EXP:ODF3	2_171053803_C_T,8_73319241_T_TGG,12_25069335_A_G
abl	Gene_EXP:OLFML2A	17_7797836_A_C,2_154854926_A_C,15_84241166_A_C,6_30705792_T_G,7_72942379_A_C
abl	Gene_EXP:OPHN1	12_54002598_T_G
abl	Gene_EXP:OSMR	11_65547388_T_G
abl	Gene_EXP:PABPC4L	15_75266048_A_G
abl	Gene_EXP:PCDH9	6_46867169_TG_T
abl	Gene_EXP:PDLIM7	16_84872374_G_C
abl	Gene_EXP:PERP	6_167373419_T_C,8_100924055_G_A
abl	Gene_EXP:PHYHIPL	13_113159942_A_G,16_30953637_A_C
abl	Gene_EXP:PLD2	15_84407910_G_A
abl	Gene_EXP:PLEC	7_72942379_A_C,10_11921140_T_G,10_79312556_A_G,12_51745916_T_G
abl	Gene_EXP:PLOD1	2_113934259_C_T
abl	Gene_EXP:PLS3	19_4911043_A_C
abl	Gene_EXP:POU2F3	16_10969154_C_T
abl	Gene_EXP:PPAP2A	5_133233474_T_G,12_57244313_A_C
abl	Gene_EXP:PPIP5K2	2_178769706_G_T,11_129905704_C_T
abl	Gene_EXP:PPP6R1	17_43829748_T_G
abl	Gene_EXP:PREX1	9_34371054_A_C
abl	Gene_EXP:PRKCQ	9_33796659_C_T,9_33796705_C_G,9_33798019_A_G
abl	Gene_EXP:PRSS23	10_11921140_T_G,13_113325635_A_G
abl	Gene_EXP:PRSS57	9_33796659_C_T
abl	Gene_EXP:PSMB9	10_11921140_T_G,11_12162199_T_G,16_55415_T_G,X_2856636_A_C
abl	Gene_EXP:PSTPIP2	2_182063828_G_C,6_143760631_C_A,6_143772215_C_T
abl	Gene_EXP:PTRF	6_30705792_T_G,12_57178583_A_C,8_122952205_T_G,11_94082585_T_C,13_113159942_A_G
abl	Gene_EXP:PVRL2	17_999610_T_C
abl	Gene_EXP:REP15	12_121222019_A_C,2_134946094_C_T,X_130145432_T_G,3_100302035_G_T,11_73355795_A_G
abl	Gene_EXP:RNF169	6_119180436_T_TAA
abl	Gene_EXP:RUNDC3A	10_11921140_T_G,13_113159942_A_G
abl	Gene_EXP:RUNX1	9_33796659_C_T,9_33796705_C_G
abl	Gene_EXP:RUNX1	1_78629896_T_C,2_108507561_T_G,8_7290003_A_C,10_11921140_T_G
abl	Gene_EXP:RXRA	15_30087620_G_A,15_32400109_G_A
abl	Gene_EXP:SEMA4D	11_125626705_T_G
abl	Gene_EXP:SEMA4G	6_146733274_T_TA
abl	Gene_EXP:SERPINE2	7_72942379_A_C
abl	Gene_EXP:SHF	2_108507561_T_G,7_149432379_A_C
abl	Gene_EXP:SLC25A37	2_182063828_G_C
abl	Gene_EXP:SNAP25	2_71424561_G_GT
abl	Gene_EXP:SOGA2	3_51980957_A_C
abl	Gene_EXP:ST18	10_133626012_T_A,10_133626013_G_A
abl	Gene_EXP:SYP	13_113159942_A_G,16_1817242_T_C
abl	Gene_EXP:TAPBP	11_12162199_T_G,12_40313960_G_T,16_30953637_A_C
abl	Gene_EXP:TCEB3	14_67333008_A_G
abl	Gene_EXP:TEAD3	18_166710_TTAAAA_T,18_166819_T_C,18_264012_G_A
abl	Gene_EXP:THBS1	2_60761746_T_G,8_7290003_A_C,10_50311228_T_G,11_12162199_T_G,19_4911043_A_C
abl	Gene_EXP:THBS1	15_65447029_G_A
abl	Gene_EXP:TIGD1	1_150261398_T_G,17_55774876_T_G
abl	Gene_EXP:TMEM63A	6_73622013_G_C,6_73635330_C_T,11_65547388_T_G
abl	Gene_EXP:TMEM92	8_1565648_A_G,9_61104415_C_T
abl	Gene_EXP:TNFRSF21	20_8802237_G_A
abl	Gene_EXP:TRAM2	1_26457907_T_G,22_21127217_C_G
abl	Gene_EXP:TRAM2	11_12162199_T_G,12_40313960_G_T,13_113159942_A_G
abl	Gene_EXP:TRIM29	12_94248247_C_T,15_50747694_T_C
abl	Gene_EXP:TRIP10	14_20381224_T_G
abl	Gene_EXP:TSC22D3	3_101857033_AT_A
abl	Gene_EXP:TSPAN4	11_12162199_T_G
abl	Gene_EXP:TXNL4A	11_124397016_A_G
abl	Gene_EXP:UBE2Q1	1_228279161_C_T,1_228303932_G_A,3_56753664_A_G
abl	Gene_EXP:VCL	10_97936313_A_C
abl	Gene_EXP:WDR1	12_122976696_T_G
abl	Gene_EXP:WFDC2	2_97152499_A_C,2_97152524_G_T,2_97152525_C_G,2_97152527_G_T,2_97152546_G_C
abl	Gene_EXP:WT1	9_33796659_C_T,9_33796705_C_G,9_33798019_A_G
abl	Gene_EXP:WWC3	19_4911043_A_C,17_7797836_A_C,19_15113629_A_C,16_70661204_T_G,14_93183653_A_C
abl	Gene_EXP:YES1	1_16580833_G_T
abl	Gene_EXP:ZNF302	17_36013794_G_A
abl	Gene_EXP:ZNF397	1_26457907_T_G,15_56693096_A_C,22_21127217_C_G,22_22643666_C_G
abl	Gene_EXP:ZNF423	11_65501241_T_G

[표 15]에 제시된 FRH 들의 해당 유전자(gene) 발현과의 상관도(P-value) 및 약물과의 상관도(P-value)를 산출한 결과가 아래 [표 16]에 정리되어있다.

또한, [표 15]에 제시된 FRH들이 포함되어 발현된 유전자들 중 주요 유전자와 각각의 ABL 약물과의 상관도(P-value)를 산출한 결과가 도 31에 도시되어 있다.

이들 [표 16] 및 [도 31]로부터 [표 16]의 두가지 상관도(P-value)가 공통적으로 낮은 유전자(gene)에 포함된 FRH(s)가 ABL 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

DrugPathway	GENE	Variants	Var _Drug( pval )	Var _ Exp ( Pval )
abl	MEI1_1	chr22_41743050_G_A	4.85E-06	0.048265101
abl	MYO1E_1	chr15_59223315_G_A	9.45E-06	0.007356789
abl	HSPG2_1	chr1_21855190_T_G	3.11E-05	0.047030976
abl	DUS1L_1	chr17_82060026_C_T	3.91E-05	0.03583129
abl	ANXA2_1	chr15_60382524_A_G	5.75E-05	0.01380595
abl	CDA_1	chr1_20613970_T_C	0.000123749	0.01233326
abl	R3HDM1_1	chr2_135621624_GT_G	0.000150326	0.007933574
abl	HMGB1_1	chr13_30465849_T_C	0.000160907	1.54E-07
abl	TRIM35_1	chr8_27311444_G_A	0.000300142	0.010188344
abl	NMT2_1	chr10_15119275_A_C	0.000338877	0.015194231
abl	WWC1_1	chr5_168453939_T_G	0.000400908	0.007809824
abl	EPB41_1	chr1_28987461_G_A	0.000407874	0.032052572
abl	TGS1_1	chr8_55790504_CT_C	0.000507403	0.000527822
abl	CLIP4_1	chr2_29189528_C_T	0.000680402	0.012550596
abl	PPFIBP1_1	chr12_27671307_G_A	0.000932648	0.043451196
abl	GNG12_1	chr1_67707581_C_T	0.000988807	0.022170841
abl	MATN3_1	chr2_20002159_T_TACAC	0.000997596	0.02071966
abl	LAMA5_1	chr20_62325178_T_C	0.001153135	0.010970602
abl	SECISBP2_1	chr9_89319872_A_G	0.001203729	0.020014055
abl	CARD10_1	chr22_37506170_T_C	0.001543214	0.032625328
abl	CELF3_1	chr1_151714507_T_A	0.001901287	0.026406472
abl	RPRD2_1	chr1_150470594_A_C	0.002054115	0.049994398
abl	LONP1_1	chr19_5707040_C_G	0.002145064	0.014919269
abl	CELSR1_1	chr22_46397746_T_G	0.002174791	0.029193759
abl	AVPI1_1	chr10_97677649_A_G	0.002288252	0.001581419
abl	HEATR5A_1	chr14_31321626_G_C	0.002664426	0.037377577
abl	ABCC3_1	chr17_50687493_T_G	0.002687235	0.008875192
abl	BCL9L_1	chr11_118897861_A_C	0.003330363	0.034238861
abl	ATP9A_1	chr20_51712877_T_C	0.003711948	0.007942465
abl	PPL_1	chr16_4899248_T_G	0.003916476	0.036032874
abl	WTIP_1	chr19_34482571_G_A	0.004231715	0.04930162
abl	SEC11C_1	chr18_59152698_T_C	0.004414812	0.00225746
abl	RIN2_1	chr20_19990244_G_A	0.004460992	0.013004393
abl	VPS13C_1	chr15_61910091_C_T	0.004506626	0.031208891
abl	WAS_1	chrX_48691219_A_C	0.004569497	0.02612273
abl	ITGA2_1	chr5_53062931_TA_T	0.005690843	0.016066848
abl	SNX6_1	chr14_34581380_G_T	0.006210652	0.003379828
abl	ITGB5_1	chr3_124769064_T_G	0.006500498	0.000658854
abl	KIF13A_1	chr6_17796543_CTT_C	0.006766834	0.022643788
abl	HNRNPD_1	chr4_82373387_A_G	0.006955259	0.035424294
abl	PDE7A_1	chr8_65724444_TATAA_T	0.006982791	0.049491005
abl	TAB1_1	chr22_39417620_CA_C	0.007324331	0.041922448
abl	TSPAN17_1	chr5_176657159_A_G	0.009147394	0.031164715
abl	MYO1C_1	chr17_1484178_C_T	0.009858187	0.007802374
abl	CDC42BPA_1	chr1_227318293_C_CG	0.010493359	0.000358115
abl	ACTN4_1	chr19_38728028_T_G	0.011156467	0.005408687
abl	MET_1	chr7_116757685_T_G	0.012677621	5.06E-05
abl	GPC1_1	chr2_240451010_T_G	0.013814172	0.00346274
abl	HERC1_1	chr15_63725445_C_A	0.014048274	0.007901005
abl	RAB13_1	chr1_153982198_T_C	0.015384036	0.007436568
abl	UBE2N_1	chr12_93411182_C_T	0.015885474	1.51E-06
abl	STRBP_1	chr9_123266116_C_G	0.017136074	0.001078377
abl	EZH1_1	chr17_42729015_C_CA	0.018478925	0.00312166
abl	RNASEH2B_1	chr13_50956394_G_T	0.01852788	0.005925233
abl	LTBP3_1	chr11_65547976_T_G	0.019306265	0.001002058
abl	EGFR_1	chr7_55205662_A_C	0.020078083	0.000779757
abl	LPIN3_1	chr20_41358465_C_G	0.020089538	6.89E-05
abl	PHF21A_1	chr11_46079428_CT_C	0.020895851	0.00265565
abl	SPR_1	chr2_72891611_A_C	0.021434042	0.000101783
abl	RCHY1_1	chr4_75509142_T_A	0.022232183	7.00E-06
abl	EPHA2_1	chr1_16148437_A_C	0.023495387	0.003022958
abl	GMEB1_1	chr1_28690201_G_T	0.025608914	0.005247117
abl	KRI1_1	chr19_10565667_A_T	0.026306225	2.71E-07
abl	MADD_1	chr11_47325027_T_C	0.027877784	0.001497343
abl	ITGAV_1	chr2_186622542_G_T	0.027935094	0.000708467
abl	FN1_1	chr2_215384980_GA_G	0.028277863	0.006411138
abl	ITGB8_1	chr7_20404676_A_G	0.03058173	0.00229404
abl	MYOF_1	chr10_93341723_C_T	0.031403296	1.02E-05
abl	MICALL1_1	chr22_37911902_T_C	0.031573614	0.005136303
abl	TXNL4A_1	chr18_80033872_T_C	0.035325542	0.000843174
abl	AHR_1	chr7_17339074_A_C	0.036910472	0.009928124
abl	HCFC1_1	chrX_153963207_T_G	0.040430125	0.001579155
abl	TJP1_1	chr15_29761137_A_C	0.040841908	0.005695684
abl	DPF1_1	chr19_38216453_A_C	0.041618699	0.002769532
abl	TUFT1_1	chr1_151565936_G_A	0.042197322	0.004559558
abl	CNN3_1	chr1_94903018_TA_T	0.044343955	0.002044509
abl	CALD1_1	chr7_134891710_CTT_C	0.044361406	0.006749784
abl	DCP1A_1	chr3_53342054_G_C	0.044944752	0.003471409
abl	CNBP_1	chr3_129183756_G_T	0.045255004	0.001660507
abl	CDC42BPB_1	chr14_102952453_T_G	0.046084899	0.003315245
abl	ZNF557_2	chr19_7083618_A_G,chr19_7083750_A_G	0.00011707290070365984, 6.389914683218769e-05	1.6329734686551152e-07,4.640996358288638e-07
abl	TSC22D1_2	chr13_44574373_G_T,chr13_44436480_G_A	0.00011795878001107085,0.0037018440403040202	0.0064804726533923464,0.03180017409101453
abl	KDM2B_2	chr12_121579943_C_CA,chr12_121444386_T_G	0.0001937979358872413,0.00792596940180308	0.01794421156168876,0.019501973878425127
abl	TMEM206_3	chr1_212365230_C_T,chr1_212377513_G_A,chr1_212377773_C_T	0.00020121681284993422,0.0003349904631200686,5.8829810838971604e-05	0.015527989364148976,0.03220676605475732,0.012309846725869236
abl	CNOT10_2	chr3_32727933_TAA_T,chr3_32704796_GT_G	0.0004336510041481753,0.008993061026214434	0.009535253937430231,0.00725632017358903
abl	AHNAK2_6	chr14_104939818_T_C,chr14_104947943_T_G,chr14_104955559_A_C,chr14_104949306_T_C,chr14_104950989_T_C,chr14_104944923_A_G	0.0013733032135289033,9.993054536650758e-05,0.0009826292819827367,0.008303598761450906,0.009151781473220755,0.016815570915054142	0.0009255099251631373,0.014057846162243957,0.00506490504122054,0.005256944789299486,0.039201386575838416,0.004782218518041667
abl	HNRNPH1_2	chr5_179614784_GAAAAA_G,chr5_179616992_TA_T	0.0015622332101704927,0.013101283499781437	0.009729395921872941,0.006282233288170697
abl	KCTD11_2	chr17_7355768_G_A,chr17_7353417_T_G	0.0021551269324258863,0.011987917410278012	0.042125567363077016,0.0012683162409826913
abl	DCBLD2_2	chr3_98800637_G_A,chr3_98822022_G_A	0.002171037536345973,0.000251692831370466	0.02405283820151249,0.02321925017861924
abl	MICALL2_6	chr7_1434706_A_T,chr7_1436884_C_A,chr7_1436960_A_G,chr7_1434574_G_A,chr7_1438692_G_A,chr7_1438940_G_A	0.0035785281207345704,0.005806506395454868,0.0023336782590812483,0.003953693182824404,0.01322256820373324,0.01322256820373324	0.03116600791585888,0.020144032243767682,0.0387968938865376,0.018579241850634483,0.001706040259270731,0.001706040259270731
abl	YEATS4_3	chr12_69360050_G_A,chr12_69360067_T_C,chr12_69359732_G_C	0.004863813186856697,0.017375818716536366,0.03137776422130159	0.00020734016607029562,9.576513142549652e-05,0.00015854860163792644
abl	FAM129B_2	chr9_127505498_C_G,chr9_127507507_A_G	0.0058285941972244645,0.02690463941303876	0.011307547073529664,0.009068416405751362
abl	DAZAP1_2	chr19_1432575_T_C,chr19_1434836_G_C	0.007270894232908141,0.04710249822900437	0.008783799588482919,0.0025498805972486143
abl	TRIO_2	chr5_14390880_CT_C,chr5_14489165_TA_T	0.008880626014071066,0.01650056581622358	7.026077789590974e-05,0.0025442006562780626
abl	LTBR_2	chr12_6385217_T_C,chr12_6385074_A_G	0.009079148191429435,0.006460458599235777	9.805545850814532e-05,0.044833733345219534
abl	CRIM1_2	chr2_36479368_G_C,chr2_36441370_A_C	0.009119609813496462,0.019906184227680684	0.012444715286562538,0.003648330338783967
abl	LRRC1_2	chr6_53795560_C_T,chr6_53922469_G_C	0.01198676814286411,0.0006843529222630762	0.000908035692517222,0.04843244804719673
abl	PLEC_3	chr8_143935900_T_G,chr8_143916360_A_G,chr8_143919099_A_G	0.014640529544546175,0.009983558087568838,0.034402276881097434	0.0004960012901022363,0.00910116635228719,0.0010288222361061275
abl	CCAR1_4	chr10_68737725_A_G,chr10_68749117_T_C,chr10_68786466_C_T,chr10_68747145_CT_C	0.01483460962771855,0.019812419206917474,0.021724978822350548,0.012199365670034771	0.007861846127742463,0.007748422295395019,0.009002153564015953,0.007417608363424872
abl	PBRM1_10	chr3_52550415_T_TCTC,chr3_52550699_A_G,chr3_52576635_T_A,chr3_52603470_C_G,chr3_52609291_A_G,chr3_52658108_G_A,chr3_52658343_C_G,chr3_52642048_AC_A,chr3_52642050_A_T,chr3_52658412_CTT_C	0.015475400089384512,0.0016628718776702444,0.035404535122126136,0.013312042665148668,0.0242839606361519,0.02159841119723304,0.03729870903666122,0.025323429673084204,0.025323429673084204,0.0001941847064581337	0.0035430700286634563,0.0001926448792301472,0.007441673662340349,0.002758979013645352,0.0010612844220239503,0.004958532862731571,0.004683945580784586,0.00010786476378721626,0.00010786476378721626,0.04797045127180218
abl	EPAS1_2	chr2_46356096_C_A,chr2_46375583_T_C	0.01783131944184612,0.0010999393665466503	0.008349664569290316,0.024779624499683697
abl	MYL12B_2	chr18_3277079_C_A,chr18_3261766_G_T	0.02040887855273308,0.006963645724708455	0.0006636499143577351,0.002628020597022407
abl	ASPH_3	chr8_61578734_T_G,chr8_61642872_G_A,chr8_61638365_TA_T	0.02703041744922913,0.04217140046834995,0.0037026849241301204	0.00027481062695969863,9.242250914202104e-05,0.0033421074285719613
abl	CTTN_2	chr11_70433765_G_C,chr11_70433037_T_G	0.028796315723836858,0.0215077683383786	0.008528354106314544,0.004388396641544275
abl	GBP3_2	chr1_89009135_A_G,chr1_89013185_G_A	0.03712796271516626,0.046403726190448136	2.531316619591342e-10,0.003766535351837685
abl	RBM6_3	chr3_50077082_C_T,chr3_50066484_G_A,chr3_50075273_C_A	0.03754138190716002,0.009406589543431777,0.006286329345703225	4.469564601606787e-06,0.014325869585835831,0.04790544676634136
abl	GULP1_2	chr2_188589974_C_CT,chr2_188569425_C_A	0.04155742757047321,0.00797269939608827	0.004507263398919969,0.006203700518672077
abl	RAI14_2	chr5_34822821_T_C,chr5_34795871_A_G	6.659980942617595e-05,0.005987810799744655	0.002995737088482826,0.006423617908157835

chromatin 약물에 대한 반응성 바이오 마커

Drug_Class	Gene_exp	바이오마커 ( 발현조절변이세트 )
chromatin	Gene_EXP:ABHD12	2_190469793_G_C
chromatin	Gene_EXP:ABHD6	12_52771095_C_G,1_26457907_T_G,5_141432375_A_C,2_119366546_A_G,22_18847351_G_C
chromatin	Gene_EXP:ABI3BP	16_87644643_G_A
chromatin	Gene_EXP:ACVR1B	1_26457907_T_G
chromatin	Gene_EXP:ACVR1B	2_113934259_C_T,5_181155466_T_G,10_79312556_A_G,11_12162199_T_G,12_6818898_A_C
chromatin	Gene_EXP:ACVR1B	2_68528704_T_C
chromatin	Gene_EXP:ACVR2B	3_128945112_G_A,13_113159942_A_G,11_34452090_T_G,16_1817242_T_C,11_65547388_T_G
chromatin	Gene_EXP:ADAM10	17_63963708_T_C
chromatin	Gene_EXP:AFMID	14_70800628_C_T,17_80090022_T_G,3_119147558_G_A,12_6941768_C_A,3_196782572_G_T
chromatin	Gene_EXP:AKAP1	16_72119226_C_G
chromatin	Gene_EXP:ALKBH2	19_3281403_A_C,16_30953637_A_C,8_27431326_A_G,10_73803641_A_G,11_12162199_T_G
chromatin	Gene_EXP:AMD1	10_133625692_C_T,19_41116300_T_C
chromatin	Gene_EXP:ANKIB1	2_218827668_A_C
chromatin	Gene_EXP:ANXA1	13_113159942_A_G,16_1817242_T_C,10_11921140_T_G,2_113934259_C_T,12_51745916_T_G
chromatin	Gene_EXP:ANXA4	6_33799054_A_G,8_27431326_A_G,8_30756677_T_G,19_11402175_A_C
chromatin	Gene_EXP:ANXA5	5_181155466_T_G,9_69516199_A_C,12_51745916_T_G,13_113325635_A_G
chromatin	Gene_EXP:APEX1	17_55774876_T_G
chromatin	Gene_EXP:ARHGAP19	14_55169342_TAAA_T
chromatin	Gene_EXP:ARID2	11_12162199_T_G,16_72119226_C_G,16_72129067_G_T,16_72164743_G_A
chromatin	Gene_EXP:ARL1	6_25488355_C_T,6_25510468_CAT_C,9_93293047_T_G,12_51745916_T_G,13_113159942_A_G
chromatin	Gene_EXP:ASB13	17_28613683_A_C
chromatin	Gene_EXP:ASCL1	7_72942379_A_C
chromatin	Gene_EXP:ATG4A	2_61492168_C_A,2_113934259_C_T,9_35398502_T_G,9_108900415_C_A,16_87644643_G_A
chromatin	Gene_EXP:ATIC	7_34811781_C_G,12_40313960_G_T
chromatin	Gene_EXP:ATP11C	1_26457907_T_G
chromatin	Gene_EXP:ATP5B	1_54243266_A_G,6_31966660_T_G
chromatin	Gene_EXP:ATP6V1A	9_69516199_A_C
chromatin	Gene_EXP:ATXN7L3B	15_65451964_A_G,2_108507561_T_G,2_113934259_C_T,12_57062993_T_G,5_181155466_T_G
chromatin	Gene_EXP:BAZ1A	15_65451964_A_G
chromatin	Gene_EXP:BCCIP	1_219979389_T_A,19_11402175_A_C
chromatin	Gene_EXP:BCL11B	1_26457907_T_G,5_141432375_A_C,22_22643666_C_G
chromatin	Gene_EXP:BCL7A	10_11921140_T_G,11_12162199_T_G,13_113159942_A_G
chromatin	Gene_EXP:BEND3	15_75524142_T_C,15_75876091_T_G
chromatin	Gene_EXP:BEND4	6_37022626_A_C,1_150261398_T_G,2_237368621_T_G,5_181155466_T_G,12_6818898_A_C
chromatin	Gene_EXP:BHLHE40	11_12162199_T_G,8_122952205_T_G,6_30705792_T_G,14_93183653_A_C,8_7290003_A_C
chromatin	Gene_EXP:BLVRB	15_20566681_C_G
chromatin	Gene_EXP:BMP1	7_72942379_A_C,11_12162199_T_G,17_7797836_A_C
chromatin	Gene_EXP:BMS1	1_114405659_A_G
chromatin	Gene_EXP:BPTF	17_55774876_T_G
chromatin	Gene_EXP:C12orf10	10_73803641_A_G
chromatin	Gene_EXP:C12orf23	16_72119226_C_G
chromatin	Gene_EXP:C12orf29	4_173528913_A_G,10_79312556_A_G,12_40313960_G_T,15_65451964_A_G
chromatin	Gene_EXP:C12orf45	9_127910024_A_C
chromatin	Gene_EXP:C14orf93	20_42084724_T_C
chromatin	Gene_EXP:C16orf59	19_9566733_T_G
chromatin	Gene_EXP:C17orf80	16_72119226_C_G,16_72129067_G_T
chromatin	Gene_EXP:C2orf44	7_108023984_G_A,7_108024001_C_T,11_65547388_T_G,14_55169342_TAAA_T
chromatin	Gene_EXP:C6orf1	4_74038466_A_C
chromatin	Gene_EXP:C8orf34	1_17244272_C_G,1_17265626_T_C
chromatin	Gene_EXP:CACNA2D2	15_67236036_T_G
chromatin	Gene_EXP:CAMKV	3_128945112_G_A,13_113159942_A_G,16_1817242_T_C,20_42084724_T_C
chromatin	Gene_EXP:CASKIN1	10_11921140_T_G
chromatin	Gene_EXP:CAV1	12_51745916_T_G,13_39724512_C_T,17_81086334_C_G
chromatin	Gene_EXP:CBR3	3_128945112_G_A,8_7290003_A_C,8_30756677_T_G,22_22098988_G_T,12_6818898_A_C
chromatin	Gene_EXP:CBX2	17_80352778_T_G,7_72942379_A_C,10_73803641_A_G
chromatin	Gene_EXP:CCDC107	11_1242476_T_G,20_62661184_C_T,17_19414393_T_G,4_74038466_A_C,16_259458_T_G
chromatin	Gene_EXP:CCDC138	8_30756677_T_G,12_40313960_G_T,15_75524142_T_C
chromatin	Gene_EXP:CCDC43	8_7290003_A_C
chromatin	Gene_EXP:CCDC77	7_108023984_G_A
chromatin	Gene_EXP:CCNB1IP1	17_55774876_T_G
chromatin	Gene_EXP:CCNT1	1_197912561_T_G,5_115984518_A_T,8_98032165_T_G,15_65451964_A_G
chromatin	Gene_EXP:CCT2	12_40313960_G_T
chromatin	Gene_EXP:CCT3	1_16589114_C_T,1_146969331_G_A
chromatin	Gene_EXP:CCT4	7_108023984_G_A
chromatin	Gene_EXP:CCT7	12_40313960_G_T
chromatin	Gene_EXP:CCT8	7_108023984_G_A,7_108024001_C_T,8_61583890_T_A
chromatin	Gene_EXP:CD151	6_158785582_A_C,1_54243266_A_G,11_12162199_T_G,1_234373536_T_G,15_84241166_A_C
chromatin	Gene_EXP:CD44	2_113934259_C_T,12_40313960_G_T,12_51745916_T_G,15_75524142_T_C
chromatin	Gene_EXP:CD63	5_181155466_T_G
chromatin	Gene_EXP:CD99L2	9_108900415_C_A,16_21550183_G_T,17_7797836_A_C,1_54243266_A_G,X_129751754_A_C
chromatin	Gene_EXP:CEBPD	6_150926303_A_G
chromatin	Gene_EXP:CECR5	5_181155466_T_G
chromatin	Gene_EXP:CENPV	5_181155466_T_G
chromatin	Gene_EXP:CEP95	11_12162199_T_G,17_55774876_T_G
chromatin	Gene_EXP:CERCAM	6_30705792_T_G
chromatin	Gene_EXP:CFLAR	3_128945112_G_A,17_55774876_T_G,7_108023984_G_A,16_67878678_T_G,20_42084724_T_C
chromatin	Gene_EXP:CHD4	12_51745916_T_G
chromatin	Gene_EXP:CHD7	11_65547388_T_G,12_40313960_G_T
chromatin	Gene_EXP:CHMP4B	16_66912991_CGT_C
chromatin	Gene_EXP:CIAPIN1	12_109800676_G_A
chromatin	Gene_EXP:CIB1	1_149852603_A_G,1_150261398_T_G,13_113159942_A_G,16_1817242_T_C
chromatin	Gene_EXP:CLOCK	4_17664674_G_A,6_83940275_G_T,12_10433951_G_C
chromatin	Gene_EXP:CMPK1	16_18379704_T_G
chromatin	Gene_EXP:CNOT6	1_16589114_C_T,15_75524142_T_C
chromatin	Gene_EXP:COPB2	19_16503339_T_G
chromatin	Gene_EXP:COPS7B	1_150261398_T_G,10_11921140_T_G,10_97048952_T_G,19_3281403_A_C
chromatin	Gene_EXP:COQ10B	1_149852603_A_G,13_113159942_A_G
chromatin	Gene_EXP:CRAT	6_30705792_T_G,17_55774876_T_G
chromatin	Gene_EXP:CREB3	1_54243266_A_G,5_181155466_T_G,11_12162199_T_G,12_6818898_A_C,7_72942379_A_C
chromatin	Gene_EXP:CRIM1	1_20724406_A_C,12_40313960_G_T,17_44212322_A_G
chromatin	Gene_EXP:CRMP1	1_26457907_T_G,22_21127217_C_G
chromatin	Gene_EXP:CTCF	17_81086334_C_G
chromatin	Gene_EXP:CTGF	2_188994726_T_G,13_113159942_A_G
chromatin	Gene_EXP:CTSA	5_181155466_T_G,11_12162199_T_G,16_87644643_G_A
chromatin	Gene_EXP:CTSB	2_27774175_G_T,5_38950065_A_T,5_181155466_T_G,7_72942379_A_C,16_87644643_G_A
chromatin	Gene_EXP:CYP2J2	1_26457907_T_G,5_141432375_A_C,15_42142087_A_C
chromatin	Gene_EXP:CYTH1	1_112520503_A_G
chromatin	Gene_EXP:DAP	12_51745916_T_G
chromatin	Gene_EXP:DAZAP1	6_73622013_G_C,6_73635330_C_T
chromatin	Gene_EXP:DDX1	1_158845552_TTTTAAG_T,2_131238127_C_T,2_237763246_G_A,16_69977378_CCT_C
chromatin	Gene_EXP:DDX20	8_30756677_T_G
chromatin	Gene_EXP:DDX25	2_61492168_C_A,5_181155466_T_G,7_72942379_A_C,11_43920052_A_C,12_40313960_G_T
chromatin	Gene_EXP:DLG2	8_30756677_T_G
chromatin	Gene_EXP:DLL3	13_113159942_A_G
chromatin	Gene_EXP:DNMT3A	2_113934259_C_T,7_72942379_A_C,11_12162199_T_G
chromatin	Gene_EXP:DPH5	8_12430448_C_T
chromatin	Gene_EXP:DSEL	9_113323143_G_A,19_36449796_A_G
chromatin	Gene_EXP:DUSP12	15_75524142_T_C
chromatin	Gene_EXP:DYNLT3	16_70661204_T_G
chromatin	Gene_EXP:E2F5	19_16896123_T_G
chromatin	Gene_EXP:ECSIT	2_60761746_T_G,2_105307612_A_C,11_43920052_A_C,12_6818898_A_C,19_4911043_A_C
chromatin	Gene_EXP:EFEMP2	11_65547388_T_G
chromatin	Gene_EXP:EFHD2	1_451649_A_AG,1_213007133_T_G,2_61492168_C_A,12_51745916_T_G
chromatin	Gene_EXP:EIF3J	1_237687398_C_T,17_36429365_A_G
chromatin	Gene_EXP:EIF3L	17_51169925_C_T,20_42084724_T_C
chromatin	Gene_EXP:EIF3M	5_112146040_A_T
chromatin	Gene_EXP:ELL2	5_181155466_T_G,10_73803531_T_C
chromatin	Gene_EXP:ENDOD1	5_80744593_A_C
chromatin	Gene_EXP:ESYT2	10_73803641_A_G,19_4911043_A_C
chromatin	Gene_EXP:EWSR1	20_42084724_T_C
chromatin	Gene_EXP:EWSR1	11_75399545_A_G,11_75402507_AT_A,11_75422721_G_A,12_11030443_C_G,22_24879556_C_A
chromatin	Gene_EXP:EXOSC4	3_61748865_T_C,17_21416455_C_G
chromatin	Gene_EXP:EXOSC5	7_108023984_G_A
chromatin	Gene_EXP:F8	1_175323536_A_T
chromatin	Gene_EXP:FAM111A	13_113159942_A_G,2_108507561_T_G,16_1817242_T_C,10_11921140_T_G,8_7290003_A_C
chromatin	Gene_EXP:FAM114A1	3_191357867_G_A,12_51745916_T_G
chromatin	Gene_EXP:FAM117B	13_113159942_A_G,7_108023984_G_A,17_55774876_T_G,11_65547388_T_G,16_1817242_T_C
chromatin	Gene_EXP:FAM126A	1_451649_A_AG,7_72942379_A_C
chromatin	Gene_EXP:FAM174A	1_198735165_C_T
chromatin	Gene_EXP:FAM214B	20_24959779_A_C
chromatin	Gene_EXP:FAP	1_183963850_T_G,11_94082585_T_C,17_55774876_T_G
chromatin	Gene_EXP:FASN	2_128268771_A_G
chromatin	Gene_EXP:FKBP4	13_113325635_A_G
chromatin	Gene_EXP:FUBP1	16_28169801_A_C
chromatin	Gene_EXP:FUCA1	1_153341603_A_C,11_12162199_T_G
chromatin	Gene_EXP:FUCA2	1_26457907_T_G,5_141432375_A_C,22_18847351_G_C,1_219210601_T_G,22_22643666_C_G
chromatin	Gene_EXP:FUCA2	5_141432375_A_C,1_26457907_T_G,22_18847351_G_C,1_219210601_T_G,22_22643666_C_G
chromatin	Gene_EXP:FUZ	10_73803641_A_G,17_6118065_A_G
chromatin	Gene_EXP:FZD3	1_26457907_T_G
chromatin	Gene_EXP:GAD1	9_128640817_A_G
chromatin	Gene_EXP:GADD45B	11_12162199_T_G,12_51745916_T_G
chromatin	Gene_EXP:GAL	2_66439901_A_C,9_37887606_C_T
chromatin	Gene_EXP:GALNTL5	10_100352318_A_G,15_34255437_A_T
chromatin	Gene_EXP:GBE1	19_47441156_T_G,10_11921140_T_G,16_58525116_G_T,5_181155466_T_G,19_9566733_T_G
chromatin	Gene_EXP:GBP3	8_7290003_A_C,12_40313960_G_T,15_75524142_T_C
chromatin	Gene_EXP:GEMIN5	1_46261223_G_A,8_42401781_A_G,9_104837455_A_G,15_72662708_A_C
chromatin	Gene_EXP:GINM1	4_154328181_A_C,7_72942379_A_C,10_73803641_A_G,11_12162199_T_G
chromatin	Gene_EXP:GLB1L2	2_113934259_C_T,7_108023984_G_A
chromatin	Gene_EXP:GLIPR1	10_11921140_T_G,19_4911043_A_C
chromatin	Gene_EXP:GLIS3	2_66439901_A_C,8_7290003_A_C,8_41957277_G_C,10_50311228_T_G,11_65547388_T_G
chromatin	Gene_EXP:GLTP	1_149852603_A_G,2_61492168_C_A
chromatin	Gene_EXP:GLTSCR2	8_12430448_C_T
chromatin	Gene_EXP:GNAI2	1_149852603_A_G,1_150261398_T_G,17_55774876_T_G,17_77213881_T_G,5_181155466_T_G
chromatin	Gene_EXP:GNS	11_1163029_C_G
chromatin	Gene_EXP:GPANK1	1_152110682_A_C
chromatin	Gene_EXP:GPC1	1_54243266_A_G,10_74988957_T_G,17_7797836_A_C,7_75364819_A_C,3_113344632_A_C
chromatin	Gene_EXP:GPS1	1_111982463_G_A
chromatin	Gene_EXP:GRPEL2	5_133233474_T_G,9_108900415_C_A,10_11921140_T_G
chromatin	Gene_EXP:GSN	5_181155466_T_G,10_11921140_T_G,13_113159942_A_G,15_75524142_T_C,16_1817242_T_C
chromatin	Gene_EXP:GTF3C2	7_128839939_T_G,7_159142364_T_G
chromatin	Gene_EXP:GTPBP4	12_40313960_G_T
chromatin	Gene_EXP:GUF1	1_213007133_T_G,5_181155466_T_G,11_12162199_T_G,11_65547388_T_G,17_55774876_T_G
chromatin	Gene_EXP:H3F3B	13_113325635_A_G
chromatin	Gene_EXP:HBQ1	8_7290003_A_C
chromatin	Gene_EXP:HDAC2	14_55169342_TAAA_T,17_55774876_T_G,11_65547388_T_G,7_108023984_G_A,15_75524142_T_C
chromatin	Gene_EXP:HEXB	11_12162199_T_G,11_65547388_T_G,15_75876091_T_G
chromatin	Gene_EXP:HIC2	2_27774175_G_T,10_11921140_T_G,13_113325635_A_G,8_7290003_A_C,1_54243266_A_G
chromatin	Gene_EXP:HIST1H3F	4_88731303_A_G,9_35398502_T_G
chromatin	Gene_EXP:HIST3H2A	10_11921140_T_G,16_18379704_T_G,20_16044565_T_G
chromatin	Gene_EXP:HMOX1	12_51745916_T_G
chromatin	Gene_EXP:HMX1	2_240451099_C_T
chromatin	Gene_EXP:HNRNPA0	16_55415_T_G,17_55774876_T_G
chromatin	Gene_EXP:HNRNPA1L2	2_113934259_C_T,5_181155466_T_G,7_72942379_A_C,12_40313960_G_T,12_51745916_T_G
chromatin	Gene_EXP:HNRNPC	14_55169342_TAAA_T,17_74350765_T_G,17_40348252_T_G,19_9566733_T_G,1_108718913_T_G
chromatin	Gene_EXP:HNRNPU	15_65451964_A_G
chromatin	Gene_EXP:HNRPDL	17_55774876_T_G
chromatin	Gene_EXP:HPDL	6_41770599_T_G,8_7290003_A_C
chromatin	Gene_EXP:HRH1	9_108900415_C_A
chromatin	Gene_EXP:HS3ST3B1	5_141432375_A_C,15_42142087_A_C
chromatin	Gene_EXP:HSPD1	17_55774876_T_G
chromatin	Gene_EXP:IFNAR1	19_7740447_T_G,16_259458_T_G,1_154331414_T_G,1_64663808_A_C,15_84241166_A_C
chromatin	Gene_EXP:IGSF9	16_87644643_G_A,13_113325635_A_G,8_7290003_A_C,2_113934259_C_T,5_181155466_T_G
chromatin	Gene_EXP:IL11RA	10_11921140_T_G
chromatin	Gene_EXP:ILF3	15_65451964_A_G,2_113934259_C_T,5_181155466_T_G,7_72942379_A_C,8_7290003_A_C
chromatin	Gene_EXP:INTS2	20_42084724_T_C
chromatin	Gene_EXP:IPO9	12_51745916_T_G
chromatin	Gene_EXP:IQGAP1	3_128945112_G_A,5_181155466_T_G,8_122952205_T_G,13_113325635_A_G,19_9566733_T_G
chromatin	Gene_EXP:ISL1	7_72942379_A_C,11_12162199_T_G
chromatin	Gene_EXP:ITGA3	5_181155466_T_G
chromatin	Gene_EXP:ITGB5	1_234373536_T_G,2_154854926_A_C,11_65547388_T_G,17_55774876_T_G
chromatin	Gene_EXP:KANK1	11_12162199_T_G
chromatin	Gene_EXP:KCNH2	5_38950065_A_T
chromatin	Gene_EXP:KCNN4	8_7290003_A_C,10_11921140_T_G,1_15381304_A_C,5_181155466_T_G,20_45938939_T_G
chromatin	Gene_EXP:KDM1A	1_26774532_T_C,5_181155466_T_G,22_42212334_A_C
chromatin	Gene_EXP:KDM3B	16_71745407_G_T,16_72119226_C_G,16_72129067_G_T,16_72164743_G_A
chromatin	Gene_EXP:KHDRBS1	5_181155466_T_G,12_6818898_A_C
chromatin	Gene_EXP:KHSRP	2_54968084_G_A
chromatin	Gene_EXP:KIF13A	10_79312556_A_G
chromatin	Gene_EXP:KIF26A	7_159142364_T_G,10_11921140_T_G
chromatin	Gene_EXP:KLHL23	10_79312556_A_G,13_113159942_A_G,13_113325635_A_G
chromatin	Gene_EXP:LAMB2	12_40313960_G_T,17_7797836_A_C,19_1356451_T_G
chromatin	Gene_EXP:LAMP1	2_154259039_T_G,10_11921140_T_G,1_99728613_A_C,7_72942379_A_C,7_32543154_A_C
chromatin	Gene_EXP:LAMP2	6_33279455_T_G
chromatin	Gene_EXP:LAPTM4B	1_24669287_T_G,2_131597280_C_G,13_19425701_C_A,19_29823727_A_C,19_3913876_A_C
chromatin	Gene_EXP:LDHB	4_108762737_T_G,11_65547388_T_G,17_55774876_T_G,15_40767895_T_G,15_65451964_A_G
chromatin	Gene_EXP:LGALS3	1_26774532_T_C,7_72942379_A_C,9_69516199_A_C,12_40313960_G_T
chromatin	Gene_EXP:LIN28B	2_113934259_C_T,5_181155466_T_G,8_7290003_A_C
chromatin	Gene_EXP:LMBR1L	7_72949311_A_C,12_109266204_T_G,20_35697711_A_C
chromatin	Gene_EXP:LONRF1	1_26457907_T_G,15_42142087_A_C,22_21127217_C_G,22_22643666_C_G
chromatin	Gene_EXP:LRPPRC	11_12162199_T_G,12_40313960_G_T
chromatin	Gene_EXP:LRRC15	1_161042141_T_G
chromatin	Gene_EXP:LY96	16_21205671_A_G
chromatin	Gene_EXP:LYPD1	1_129285_G_A
chromatin	Gene_EXP:LYST	8_7290003_A_C,16_55415_T_G
chromatin	Gene_EXP:MAK16	12_40313960_G_T
chromatin	Gene_EXP:MALT1	11_12162199_T_G,19_4911043_A_C,17_63435232_G_C,17_7797836_A_C,12_40313960_G_T
chromatin	Gene_EXP:MAN2B2	17_55774876_T_G
chromatin	Gene_EXP:MAP2K7	1_11243090_T_G,1_16734496_C_T,12_109952676_A_C,21_46245172_A_C
chromatin	Gene_EXP:MAP4	3_10819431_A_G,1_54243266_A_G,16_81270082_T_G,7_72942379_A_C,8_94407601_A_C
chromatin	Gene_EXP:MBTD1	2_113934259_C_T,11_65547388_T_G,12_57062993_T_G,15_65451964_A_G,17_55774876_T_G
chromatin	Gene_EXP:MCF2	15_42142087_A_C
chromatin	Gene_EXP:MCM10	2_170965958_A_C
chromatin	Gene_EXP:MDN1	11_65547388_T_G
chromatin	Gene_EXP:MED25	17_18282776_T_G,11_74492398_A_C,1_224418353_A_C,15_43716974_A_C,X_54813054_T_G
chromatin	Gene_EXP:MED28	8_7290003_A_C
chromatin	Gene_EXP:METAP2	2_208237181_GA_G
chromatin	Gene_EXP:MICALL2	7_72942379_A_C,8_7290003_A_C,11_12162199_T_G,12_51745916_T_G,16_30953637_A_C
chromatin	Gene_EXP:MMD	1_248441636_T_G,6_30705792_T_G,8_122952205_T_G
chromatin	Gene_EXP:MOSPD2	11_12162199_T_G
chromatin	Gene_EXP:MOXD1	5_181155466_T_G,11_12162199_T_G
chromatin	Gene_EXP:MPST	1_150261398_T_G,5_181155466_T_G,17_18353665_C_T
chromatin	Gene_EXP:MR1	1_234373536_T_G,10_79312556_A_G,15_84241166_A_C,19_7740447_T_G
chromatin	Gene_EXP:MRPL21	22_22098988_G_T
chromatin	Gene_EXP:MRPL48	5_181155466_T_G
chromatin	Gene_EXP:MRPS2	5_1798678_A_C
chromatin	Gene_EXP:MRPS21	12_40313960_G_T
chromatin	Gene_EXP:MRPS31	1_112520503_A_G,11_65547388_T_G
chromatin	Gene_EXP:MRPS35	7_108023984_G_A,7_108024001_C_T,7_108037539_G_A
chromatin	Gene_EXP:MSN	8_7290003_A_C,10_73803641_A_G
chromatin	Gene_EXP:MSRA	1_110340768_A_C
chromatin	Gene_EXP:MTM1	2_105307612_A_C,7_72942379_A_C
chromatin	Gene_EXP:MTMR7	1_20724406_A_C
chromatin	Gene_EXP:MTPAP	1_150261398_T_G,9_128964364_CT_C,11_65547388_T_G
chromatin	Gene_EXP:MTUS1	19_53998273_G_A,19_53999532_G_A
chromatin	Gene_EXP:MVP	11_68780792_C_A,11_68785018_G_A,12_40313960_G_T,15_75876091_T_G
chromatin	Gene_EXP:MYH9	1_15381304_A_C,9_69516199_A_C,10_11921140_T_G,13_113159942_A_G
chromatin	Gene_EXP:MYO1E	2_113934259_C_T,2_157299566_T_G,8_41957277_G_C,12_51745916_T_G,15_40767895_T_G
chromatin	Gene_EXP:MYOF	10_11921140_T_G,12_51745916_T_G,8_122952205_T_G,10_50311228_T_G,5_181155466_T_G
chromatin	Gene_EXP:NAA25	7_108023984_G_A
chromatin	Gene_EXP:NAGK	X_2856636_A_C
chromatin	Gene_EXP:NAP1L1	7_2269556_T_A
chromatin	Gene_EXP:NBR2	7_142944295_A_G,19_3179506_A_C
chromatin	Gene_EXP:NCL	7_108023984_G_A,11_65547388_T_G,17_55774876_T_G,13_113159942_A_G,19_3281403_A_C
chromatin	Gene_EXP:NDUFAF4	1_234373536_T_G,11_65547388_T_G,15_65451964_A_G,15_75524142_T_C
chromatin	Gene_EXP:NDUFB9	19_4911043_A_C
chromatin	Gene_EXP:NELL2	1_26457907_T_G,5_141432375_A_C
chromatin	Gene_EXP:NFKBIZ	6_47579334_T_TAA
chromatin	Gene_EXP:NIPSNAP1	2_60761746_T_G,2_86027990_C_A,5_181155466_T_G,9_37887606_C_T,12_51745916_T_G
chromatin	Gene_EXP:NMRK1	12_7433515_G_T,16_55415_T_G
chromatin	Gene_EXP:NOL11	1_1918090_A_G,8_7290003_A_C
chromatin	Gene_EXP:NOLC1	1_234373536_T_G
chromatin	Gene_EXP:NOP14	9_36058818_G_T,17_3513849_GCA_G
chromatin	Gene_EXP:NOP58	3_196782572_G_T
chromatin	Gene_EXP:NPC1	6_106621398_T_C
chromatin	Gene_EXP:NRARP	5_181155466_T_G
chromatin	Gene_EXP:NSL1	10_11921140_T_G,11_12162199_T_G
chromatin	Gene_EXP:NUCB2	10_11921140_T_G
chromatin	Gene_EXP:NUDT16	1_26457907_T_G
chromatin	Gene_EXP:NUP35	19_9566733_T_G
chromatin	Gene_EXP:NUPR1	11_20049928_A_C,12_40313960_G_T
chromatin	Gene_EXP:OPTN	2_61492168_C_A,2_113934259_C_T,20_24959779_A_C,2_10086095_C_A,15_84241166_A_C
chromatin	Gene_EXP:OSGEPL1	12_40313960_G_T
chromatin	Gene_EXP:PA2G4	12_40313960_G_T
chromatin	Gene_EXP:PARP1	13_113159942_A_G
chromatin	Gene_EXP:PATZ1	11_12162199_T_G
chromatin	Gene_EXP:PAX6	1_234309145_T_G,7_5227302_G_C,7_72942379_A_C,1_54243266_A_G,12_44376791_T_A
chromatin	Gene_EXP:PDP1	1_248441636_T_G
chromatin	Gene_EXP:PDSS1	5_180624003_T_C,12_40313960_G_T
chromatin	Gene_EXP:PEA15	8_7290003_A_C,5_181155466_T_G,10_50311228_T_G,11_12162199_T_G,2_169735166_A_C
chromatin	Gene_EXP:PFDN2	1_200988322_T_G
chromatin	Gene_EXP:PHF5A	15_82430191_A_C,1_54243266_A_G,5_140841707_A_C,11_12162199_T_G,17_737856_G_T
chromatin	Gene_EXP:PHLDA2	2_237510900_CGT_C,3_195668457_T_C,20_62310091_T_G
chromatin	Gene_EXP:PHOX2A	12_51745916_T_G
chromatin	Gene_EXP:PLAUR	7_72942379_A_C,11_12162199_T_G,12_51745916_T_G
chromatin	Gene_EXP:PLOD1	2_113934259_C_T
chromatin	Gene_EXP:POC5	12_9304133_T_C,12_31094748_T_C,Y_11344922_A_G
chromatin	Gene_EXP:POLD1	17_36104042_G_T,19_9566733_T_G
chromatin	Gene_EXP:POLE	2_217847583_C_T
chromatin	Gene_EXP:POLG2	19_4911043_A_C,22_22098988_G_T
chromatin	Gene_EXP:POLR1C	16_14868419_C_A
chromatin	Gene_EXP:POU2F1	12_51745916_T_G
chromatin	Gene_EXP:PPAT	14_55169342_TAAA_T,1_46261223_G_A,6_56557393_C_T,8_27431326_A_G,5_141478412_T_C
chromatin	Gene_EXP:PPIC	2_66439901_A_C
chromatin	Gene_EXP:PPP1CC	1_185150475_G_A,10_11921140_T_G,11_124896232_A_G
chromatin	Gene_EXP:PPP1R3C	1_172308705_AT_A
chromatin	Gene_EXP:PQLC3	10_11921140_T_G,16_18379704_T_G
chromatin	Gene_EXP:PRCC	2_105307612_A_C,4_9908299_G_A,19_8943580_T_G
chromatin	Gene_EXP:PRIM1	2_218827668_A_C
chromatin	Gene_EXP:PRMT1	1_26034759_T_G,5_181155466_T_G
chromatin	Gene_EXP:PSMB9	10_11921140_T_G,11_12162199_T_G,16_55415_T_G,X_2856636_A_C
chromatin	Gene_EXP:PTGES3	1_26457907_T_G,1_149813302_A_C
chromatin	Gene_EXP:PTP4A3	10_11921140_T_G
chromatin	Gene_EXP:PTRF	13_113159942_A_G,10_11921140_T_G,12_57178583_A_C,8_122952205_T_G,8_7290003_A_C
chromatin	Gene_EXP:PXDC1	7_159142364_T_G,11_65547388_T_G,13_113159942_A_G
chromatin	Gene_EXP:RAB27A	7_108023984_G_A,1_150261398_T_G,7_108024001_C_T,16_20737706_A_C,12_6818898_A_C
chromatin	Gene_EXP:RAN	10_11921140_T_G,19_3281403_A_C
chromatin	Gene_EXP:RANBP1	6_30705792_T_G
chromatin	Gene_EXP:RARRES3	1_213007133_T_G,12_40313960_G_T,16_87644643_G_A
chromatin	Gene_EXP:RBM27	19_48617887_T_G
chromatin	Gene_EXP:RBMX	2_113934259_C_T
chromatin	Gene_EXP:RCAN1	2_66439901_A_C,7_159142364_T_G,8_7290003_A_C,11_65547388_T_G
chromatin	Gene_EXP:RHOC	1_149852603_A_G,5_181155466_T_G,13_113159942_A_G,17_55774876_T_G
chromatin	Gene_EXP:RNF135	6_30705792_T_G
chromatin	Gene_EXP:RNF44	8_12430448_C_T,10_11921140_T_G
chromatin	Gene_EXP:RNPS1	6_26033581_T_TAAG
chromatin	Gene_EXP:RPAP1	2_96842345_G_C
chromatin	Gene_EXP:RPL11	10_72344856_T_A
chromatin	Gene_EXP:RPL13A	4_145127510_C_T,12_57470756_A_G,15_45095024_A_C,19_44985182_T_G,20_47227145_T_G
chromatin	Gene_EXP:RPL19	2_61492168_C_A
chromatin	Gene_EXP:RPL22	8_12430448_C_T
chromatin	Gene_EXP:RPL3	2_24067801_G_A
chromatin	Gene_EXP:RPL30	8_12430448_C_T
chromatin	Gene_EXP:RPL32	8_12430448_C_T
chromatin	Gene_EXP:RPRD2	1_146969331_G_A,1_146975626_G_A,1_148117837_C_T
chromatin	Gene_EXP:RPS11	4_145127510_C_T,8_12430448_C_T,17_28613683_A_C
chromatin	Gene_EXP:RPS28	15_43578884_A_G,17_18282629_T_G
chromatin	Gene_EXP:RPS5	8_12430448_C_T
chromatin	Gene_EXP:RPUSD4	15_75524142_T_C
chromatin	Gene_EXP:RRP12	5_13829939_G_A
chromatin	Gene_EXP:RSL1D1	17_55774876_T_G
chromatin	Gene_EXP:RSL24D1	9_69516199_A_C
chromatin	Gene_EXP:RUVBL1	1_247814785_G_A,1_247815694_A_G
chromatin	Gene_EXP:S100A6	7_72942379_A_C,7_159142364_T_G,8_7290003_A_C,8_30756677_T_G,10_11921140_T_G
chromatin	Gene_EXP:SAFB	8_7290003_A_C,10_11921140_T_G,13_113159942_A_G,14_55169342_TAAA_T
chromatin	Gene_EXP:SAMD4A	8_7290003_A_C
chromatin	Gene_EXP:SAMD9	5_181155466_T_G,8_7290003_A_C,11_12162199_T_G
chromatin	Gene_EXP:SAMM50	17_76009153_A_C
chromatin	Gene_EXP:SART3	10_11921140_T_G,11_12162199_T_G
chromatin	Gene_EXP:SAT1	12_40313960_G_T
chromatin	Gene_EXP:SELRC1	12_40313960_G_T
chromatin	Gene_EXP:SEPHS1	2_113934259_C_T
chromatin	Gene_EXP:SERF2	12_52013974_A_C
chromatin	Gene_EXP:SERINC3	2_105307612_A_C
chromatin	Gene_EXP:SETDB1	10_11921140_T_G
chromatin	Gene_EXP:SFPQ	8_30756677_T_G
chromatin	Gene_EXP:SGCE	15_59682341_T_A
chromatin	Gene_EXP:SH3GLB1	20_42084724_T_C
chromatin	Gene_EXP:SHF	2_108507561_T_G,7_149432379_A_C
chromatin	Gene_EXP:SLC10A3	13_113159942_A_G
chromatin	Gene_EXP:SLC25A43	1_54243266_A_G,8_7290003_A_C,19_7627786_T_G
chromatin	Gene_EXP:SLC29A3	8_7290003_A_C,8_122952205_T_G,19_19498524_A_C
chromatin	Gene_EXP:SLC2A10	8_7290003_A_C
chromatin	Gene_EXP:SLC35D1	16_18379704_T_G
chromatin	Gene_EXP:SLC35F5	13_113159942_A_G,17_6118065_A_G
chromatin	Gene_EXP:SLC39A13	6_30705792_T_G,7_108023984_G_A
chromatin	Gene_EXP:SLC5A6	7_108023984_G_A,14_22844242_T_G
chromatin	Gene_EXP:SLC6A15	17_55774876_T_G
chromatin	Gene_EXP:SLC9A7	19_4911043_A_C
chromatin	Gene_EXP:SMARCA4	5_181155466_T_G,8_7290003_A_C,11_65547388_T_G
chromatin	Gene_EXP:SMARCB1	3_197683305_A_C,5_80744593_A_C,19_9566733_T_G
chromatin	Gene_EXP:SMARCD2	17_27646578_A_C
chromatin	Gene_EXP:SMCR7L	11_12162199_T_G
chromatin	Gene_EXP:SMPD1	7_72942379_A_C,16_87644643_G_A
chromatin	Gene_EXP:SNRPB	8_119240272_G_C,12_9165341_A_C,20_36185166_C_G
chromatin	Gene_EXP:SRPX2	11_65547388_T_G
chromatin	Gene_EXP:SRSF1	16_87644643_G_A
chromatin	Gene_EXP:SRSF7	7_108023984_G_A
chromatin	Gene_EXP:SRSF7	5_181333681_C_T
chromatin	Gene_EXP:STAT2	13_113159942_A_G
chromatin	Gene_EXP:SUMF1	12_121752129_T_G,7_151560601_A_C,20_3864330_A_C,5_80744593_A_C,14_88622642_G_T
chromatin	Gene_EXP:SUPT4H1	1_13281477_A_G,1_247949628_T_C
chromatin	Gene_EXP:SYNC	15_42142087_A_C
chromatin	Gene_EXP:SYTL2	10_11921140_T_G
chromatin	Gene_EXP:TACC1	7_72942379_A_C,11_12162199_T_G,12_51745916_T_G,16_55415_T_G,16_15664675_G_T
chromatin	Gene_EXP:TADA1	10_11921140_T_G,18_41955194_A_G
chromatin	Gene_EXP:TAF3	15_75876091_T_G
chromatin	Gene_EXP:TAF5	6_33799054_A_G,7_108023984_G_A,19_3281403_A_C
chromatin	Gene_EXP:TAP1	5_181155466_T_G,8_7290003_A_C,10_11921140_T_G,11_12162199_T_G,20_42084724_T_C
chromatin	Gene_EXP:TBC1D2	1_185150475_G_A
chromatin	Gene_EXP:TCEAL4	5_127331576_G_A
chromatin	Gene_EXP:TFAP4	5_181155466_T_G,11_65547388_T_G
chromatin	Gene_EXP:TFB2M	6_32002466_A_C
chromatin	Gene_EXP:TGOLN2	2_105307612_A_C,7_72942379_A_C,8_7290003_A_C,19_7740447_T_G,19_11402175_A_C
chromatin	Gene_EXP:THOC5	1_54243266_A_G,3_197683305_A_C,22_22098988_G_T
chromatin	Gene_EXP:TIGD1	1_150261398_T_G,17_55774876_T_G
chromatin	Gene_EXP:TMBIM1	1_208039626_T_G,17_51169925_C_T,6_30329265_T_C,16_55415_T_G,2_105307612_A_C
chromatin	Gene_EXP:TMCO3	5_37175989_A_G,5_37182800_G_A,5_37187387_G_A
chromatin	Gene_EXP:TMED9	11_12162199_T_G,13_113159942_A_G
chromatin	Gene_EXP:TMEM145	10_11921140_T_G,11_34452090_T_G
chromatin	Gene_EXP:TMEM177	9_108900415_C_A,12_40313960_G_T
chromatin	Gene_EXP:TMEM184B	13_113159942_A_G
chromatin	Gene_EXP:TMEM229A	6_30705792_T_G
chromatin	Gene_EXP:TMEM45A	17_41725799_T_G,X_47247581_T_G
chromatin	Gene_EXP:TMEM50B	6_30642116_A_G,10_27223356_T_C,12_40313960_G_T,15_84241166_A_C
chromatin	Gene_EXP:TMEM97	1_150261398_T_G,12_6818898_A_C,17_55774876_T_G,20_33848655_A_C
chromatin	Gene_EXP:TOMM20	16_18379704_T_G,16_87644643_G_A,17_55774876_T_G,20_42084724_T_C,10_11921140_T_G
chromatin	Gene_EXP:TOP1MT	20_763790_T_G
chromatin	Gene_EXP:TPMT	2_61492168_C_A,9_37887606_C_T,11_12162199_T_G
chromatin	Gene_EXP:TRAM2	11_12162199_T_G,12_40313960_G_T,13_113159942_A_G
chromatin	Gene_EXP:TRAP1	9_69516199_A_C
chromatin	Gene_EXP:TRIM28	19_40695973_T_G
chromatin	Gene_EXP:TRIP6	12_51745916_T_G
chromatin	Gene_EXP:TSEN54	11_12162199_T_G,13_113325635_A_G
chromatin	Gene_EXP:TTLL12	1_220067324_T_G
chromatin	Gene_EXP:TUBA4A	7_159142364_T_G,11_65547388_T_G
chromatin	Gene_EXP:TWSG1	12_51745916_T_G
chromatin	Gene_EXP:UBA52	11_65547388_T_G,12_40313960_G_T,13_113159942_A_G
chromatin	Gene_EXP:UBE2O	1_155747580_A_G,6_30705800_T_G,10_11921140_T_G,20_42084724_T_C
chromatin	Gene_EXP:UBXN7	1_26457907_T_G,22_24252424_G_C
chromatin	Gene_EXP:UEVLD	10_11921140_T_G,11_43920052_A_C,X_2856636_A_C
chromatin	Gene_EXP:UPP1	2_61492168_C_A
chromatin	Gene_EXP:USP6NL	2_237553681_A_G
chromatin	Gene_EXP:UTP18	8_7290003_A_C
chromatin	Gene_EXP:UTRN	2_105307612_A_C,7_108023984_G_A,17_80962613_A_C,19_4911043_A_C
chromatin	Gene_EXP:VARS	15_75524142_T_C
chromatin	Gene_EXP:VASH2	5_181155466_T_G
chromatin	Gene_EXP:WASF1	2_108507561_T_G,10_43200831_A_G,16_55415_T_G
chromatin	Gene_EXP:WDR12	6_29588459_T_G,7_149253814_T_G,1_154331414_T_G,12_40313960_G_T,3_142177436_A_G
chromatin	Gene_EXP:WDR18	1_64663808_A_C
chromatin	Gene_EXP:WDR3	5_88722571_GA_G,10_5909062_T_C
chromatin	Gene_EXP:WDR75	2_190469793_G_C,1_154331414_T_G,3_196782572_G_T,7_149253814_T_G,18_14183954_G_T
chromatin	Gene_EXP:WHAMM	2_113934259_C_T
chromatin	Gene_EXP:WIPI1	1_155709773_T_G,2_127651579_A_C
chromatin	Gene_EXP:WNK2	10_11921140_T_G
chromatin	Gene_EXP:WWTR1	3_128945112_G_A,10_11921140_T_G,16_1817242_T_C
chromatin	Gene_EXP:XPO5	11_65547388_T_G,15_75524142_T_C
chromatin	Gene_EXP:YARS2	4_41631305_C_A,4_41632760_G_C
chromatin	Gene_EXP:YEATS4	1_12001708_A_G,6_31966660_T_G,12_6818898_A_C,19_9566733_T_G
chromatin	Gene_EXP:ZBED4	2_108507561_T_G,11_65547388_T_G
chromatin	Gene_EXP:ZBTB39	16_30953637_A_C
chromatin	Gene_EXP:ZBTB4	6_30705792_T_G,10_11921140_T_G,17_55774876_T_G
chromatin	Gene_EXP:ZC3H8	11_12162199_T_G
chromatin	Gene_EXP:ZNF124	2_170965958_A_C,13_113159942_A_G,17_55774876_T_G
chromatin	Gene_EXP:ZNF22	2_97507111_G_A
chromatin	Gene_EXP:ZNF33B	1_112520503_A_G
chromatin	Gene_EXP:ZNF581	8_12430448_C_T
chromatin	Gene_EXP:ZNF689	3_53183591_A_C
chromatin	Gene_EXP:ZNF74	11_65547388_T_G,17_55774876_T_G,2_113934259_C_T,2_61492168_C_A,5_181155466_T_G

[표 17]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value) 및 약물과의 상관도(P-value)를 산출한 결과가 아래 [표 18]에 정리되어있다.

또한, [표 17]에 제시된 FRH들이 포함되어 발현된 유전자들 중 주요 유전자와 각각의 CHROMATIN 약물과의 상관도(P-value)를 산출한 결과가 도 32에 도시되어 있다.

이들 [표 18] 및 [도 32]로부터 [표 18] 및 [도 32]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 CHROMATIN 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

DrugPathway	GENE	Variants	Var _Drug( pval )	Var _ Exp ( Pval )
chromatin	SPR_1	chr2_72891611_A_C	1.13E-09	0.000101783
chromatin	BCL9L_1	chr11_118897861_A_C	3.13E-08	0.034238861
chromatin	ZDHHC7_1	chr16_84981848_T_G	1.25E-07	0.007398316
chromatin	CCDC69_1	chr5_151185396_T_C	2.83E-07	0.005439839
chromatin	DDX60_1	chr4_168220820_G_T	4.91E-07	0.047715445
chromatin	RASSF5_1	chr1_206507640_A_C	6.00E-07	0.042432506
chromatin	C21orf58_1	chr21_46302477_A_G	5.32E-06	0.028316032
chromatin	KIAA0922_1	chr4_153466445_G_C	1.35E-05	0.014460739
chromatin	NR2F2_1	chr15_96331144_C_T	1.41E-05	0.041165877
chromatin	WWC2_1	chr4_183261395_G_T	2.29E-05	0.017749371
chromatin	ERRFI1_1	chr1_8013331_A_G	3.34E-05	0.000188249
chromatin	KIAA1191_1	chr5_176361895_T_C	4.29E-05	0.02279099
chromatin	QSOX1_1	chr1_180196892_T_G	5.61E-05	0.048904626
chromatin	NTN4_1	chr12_95683554_A_C	5.86E-05	0.007698614
chromatin	KIFC3_1	chr16_57765532_T_G	6.78E-05	0.038497261
chromatin	LPP_1	chr3_188484677_T_G	7.25E-05	0.027828249
chromatin	TUFT1_1	chr1_151565936_G_A	8.20E-05	0.004559558
chromatin	CDC14B_1	chr9_96496393_T_TACC	0.000102442	0.034844355
chromatin	DTX1_1	chr12_113093500_A_T	0.000105094	0.02107386
chromatin	P4HA2_1	chr5_132227207_C_T	0.000133282	0.048816114
chromatin	ARHGAP25_1	chr2_68818005_T_G	0.000231771	0.004043302
chromatin	TIMM13_1	chr19_2425296_G_C	0.000236058	0.025389471
chromatin	CAST_1	chr5_96741643_A_C	0.000249549	0.007284203
chromatin	PTPN12_1	chr7_77627576_G_C	0.000317226	0.012844299
chromatin	MED28_1	chr4_17614675_T_G	0.000322999	0.029816577
chromatin	SLC35F5_1	chr2_113723196_TA_T	0.000333219	0.009792442
chromatin	TPBG_1	chr6_82364929_T_C	0.000334942	0.003828919
chromatin	CD79B_1	chr17_63932334_A_C	0.000528438	0.048052988
chromatin	DIRC2_1	chr3_122856322_A_G	0.000825084	0.013416691
chromatin	UEVLD_1	chr11_18558312_C_A	0.000960879	0.026771319
chromatin	LRP10_1	chr14_22875577_A_C	0.001001744	0.013008771
chromatin	UGDH_1	chr4_39504307_CA_C	0.001468644	0.048378289
chromatin	VMP1_1	chr17_59841357_A_C	0.001495454	0.00700708
chromatin	DOT1L_1	chr19_2190948_TTGG_T	0.001590625	0.039142783
chromatin	OSMR_1	chr5_38933647_C_T	0.001601244	0.048095084
chromatin	CYR61_1	chr1_85581605_TA_T	0.001618999	0.000620768
chromatin	EMP1_1	chr12_13211531_T_G	0.001632317	0.001600571
chromatin	PRDM2_1	chr1_13781628_C_T	0.001853506	0.028812792
chromatin	UBE2N_1	chr12_93411182_C_T	0.001919604	1.51E-06
chromatin	PDE7A_1	chr8_65724444_TATAA_T	0.001930609	0.049491005
chromatin	ZNF775_1	chr7_150397765_G_A	0.002410672	0.02103353
chromatin	ACSS2_1	chr20_34920910_T_G	0.002415783	0.038456731
chromatin	TNRC6C_1	chr17_78049826_A_C	0.002419277	0.037719795
chromatin	OPTN_1	chr10_13108909_T_C	0.002658339	0.009854403
chromatin	FHL2_1	chr2_105398737_G_C	0.002849654	0.020214714
chromatin	TSR2_1	chrX_54440646_T_G	0.003023868	0.016676081
chromatin	PON2_1	chr7_95406313_A_C	0.003172125	9.37E-06
chromatin	RIN2_1	chr20_19990244_G_A	0.003495398	0.013004393
chromatin	ACVR1_1	chr2_157780624_GA_G	0.003989606	0.003394881
chromatin	ARRB2_1	chr17_4720324_T_G	0.004024916	0.04522165
chromatin	STRBP_1	chr9_123266116_C_G	0.005108062	0.001078377
chromatin	APLP2_1	chr11_130110790_G_A	0.006767893	0.002129537
chromatin	PPM1D_1	chr17_60656555_C_G	0.007483948	0.004279928
chromatin	MICALL2_1	chr7_1442358_T_G	0.008296918	0.00384944
chromatin	SDC4_1	chr20_45330303_T_G	0.00885313	0.000496261
chromatin	MAP4K1_1	chr19_38617327_T_G	0.009035501	0.013203631
chromatin	DDX51_1	chr12_132144264_G_A	0.00950629	0.039746501
chromatin	CD63_1	chr12_55725568_A_C	0.010191282	0.006277176
chromatin	TSEN34_1	chr19_54192354_T_G	0.015320711	0.001848481
chromatin	RND3_1	chr2_150487464_GA_G	0.016355986	0.009852344
chromatin	DYNC1LI2_1	chr16_66723584_GTTT_G	0.020987801	0.00547115
chromatin	ATG4D_1	chr19_10547046_A_G	0.025677384	0.001170719
chromatin	TEAD4_1	chr12_3019250_C_T	0.025841261	0.001625407
chromatin	SPATS2L_1	chr2_200329386_C_A	0.025958546	0.003348759
chromatin	TCF3_1	chr19_1627423_T_C	0.04297822	0.006623288
chromatin	GPX8_1	chr5_55164338_T_C	0.043500083	0.000150103
chromatin	CHD7_1	chr8_60781091_A_C	0.049386713	0.009144258
chromatin	IQCB1_1	chr3_121788568_C_T	0.049430015	1.56E-06
chromatin	CD84_2	chr1_160549875_A_G,chr1_160550877_C_G	0.00011388443370850483,0.0007812325110491749	0.011914227680681896,0.04088607952168802
chromatin	GSN_2	chr9_121300011_T_G,chr9_121321305_A_C	0.00014939533964484881,0.03316947281106813	0.027350252864946387,0.0036521684936499576
chromatin	PTPRC_2	chr1_198703381_A_C,chr1_198752063_T_C	0.00016494389721910315,0.0013479983597789753	0.02703768662070396,0.04525193826667434
chromatin	DAG1_2	chr3_49531399_T_G,chr3_49530812_A_G	0.00020026524182288077,0.006009115344867996	0.000829773140052924,0.031395065099950874
chromatin	CLEC16A_3	chr16_11156556_C_A,chr16_11060913_G_A,chr16_11042191_C_G	0.0002094249249848047,6.263351817687237e-07,0.000591215275919509	0.00562768771681351,0.001657798405900209,0.0008509758531100063
chromatin	SEMA3C_2	chr7_80748927_A_C,chr7_80758439_T_G	0.00023588106210457256,0.002402247845707725	0.04566908222348532,0.022537466343331126
chromatin	MYO1E_3	chr15_59272288_G_C,chr15_59223315_G_A,chr15_59138181_A_C	0.0002531868313324391,0.017294701356675626,0.012353995820357604	0.006181875879725325,0.0073567891788311425,0.000506485287819266
chromatin	FBRSL1_2	chr12_132582046_C_T,chr12_132490757_A_G	0.0002541174963279791,0.0016132414574028821	0.017168862085872382,0.014332097218830869
chromatin	PLAUR_2	chr19_43665377_C_A,chr19_43665506_A_C	0.0004816822177162012,0.000329711238045009	0.013703989625456308,0.02821338934893095
chromatin	UPP1_2	chr7_48108129_C_G,chr7_48108147_T_G	0.0005053096271809359,0.032569834532674265	0.0002337913556195707,0.0015081620173450355
chromatin	TM4SF1_3	chr3_149375338_T_G,chr3_149375342_T_G,chr3_149375345_A_G	0.0006450924297222392,0.00041880937510606033,0.0045963625050391855	0.00025288036755393063,0.005766354533635817,0.02993773631668
chromatin	ZNF430_4	chr19_21020746_C_T,chr19_21022725_C_T,chr19_21034405_A_G,chr19_21022773_T_G	0.0006475458714423392,0.0074498992574896375,0.001227492240630532,0.0008007999312255407	0.0014493947676260713,7.931044376997757e-06,0.043344266998276815,0.024171318376603662
chromatin	CYTIP_2	chr2_157427544_C_T,chr2_157427198_A_G	0.000837855207497095,0.004314698497827655	0.016967272956506692,0.0066627404504453576
chromatin	FAM129B_3	chr9_127531490_GA_G,chr9_127525143_T_G,chr9_127578821_C_G	0.000922821517572468,0.0002411893320187629,8.276570085958934e-05	0.031013612085774283,0.010661251800502545,0.0009666899162254512
chromatin	SEC11C_2	chr18_59152698_T_C,chr18_59139887_T_G	0.0009260156067678403,0.049013482279269986	0.0022574597582570113,0.007830715004334495
chromatin	SERPINB6_3	chr6_2955641_A_C,chr6_2955644_A_C,chr6_2959401_A_C	0.001043382693355795,0.024971781697072672,0.0010045092345408332	0.01355817950847752,0.003892754006925403,0.039976665559382514
chromatin	HEXB_5	chr5_74696581_T_G,chr5_74696784_G_A,chr5_74715459_CT_C,chr5_74715716_T_A,chr5_74715716_T_TA	0.0011109425360834742,0.0004588063308077307,0.00032306189000466006,0.0012875359612772113,0.013801634858228495	0.0076182846696747,0.037654298343869685,0.0009700644073606587,0.0006894634360309071,0.008716125756790354
chromatin	CHAF1A_5	chr19_4431899_C_T,chr19_4442339_C_T,chr19_4443049_T_C,chr19_4422720_A_G,chr19_4442532_T_C	0.0013371878989745694,4.704638650715319e-06,0.002601657035134123,0.00848724820837247,0.0008277326854784058	1.913287638550038e-06,2.142565869765625e-07,2.294297809586175e-06,0.024620616607439628,0.010330162535447171
chromatin	DTNBP1_5	chr6_15522870_T_C,chr6_15662701_T_G,chr6_15524467_T_C,chr6_15637909_C_A,chr6_15651411_GA_G	0.00140727662017035,0.0007340285829190258,0.000563588210134313,0.0015365486679584585,0.012631556103580063	0.02838345350893315,0.001004314451212422,0.0038345211108275156,0.02038116210082405,0.0014349866138238813
chromatin	NPC1_6	chr18_23533587_A_G,chr18_23531466_TG_T,chr18_23543332_G_GA,chr18_23556539_A_C,chr18_23551637_T_C,chr18_23540944_CT_C	0.001437129484746987,7.150026947753571e-05,0.0029007221429512673,0.0002201554381797956,0.00283655966462793,0.003557570436749789	0.049542946772028126,0.03680603821841593,0.0011845211365567286,0.011218938268584914,0.00977392034448968,0.040822963170832685
chromatin	DCK_2	chr4_71023678_G_A,chr4_71023683_A_T	0.0025792753639569685,0.004519208391207111	0.0495745351142595,0.03292890320415958
chromatin	MYOF_5	chr10_93402739_A_T,chr10_93341723_C_T,chr10_93456833_C_T,chr10_93359764_G_A,chr10_93379679_T_C	0.0031553117726987327,0.0003251886046767745,0.0012115888716542418,0.0011033881652818386,1.1152022033742226e-05	0.008275987890594253,1.0154009952651607e-05,4.5730649026336375e-05,0.04572104850464974,0.0006543495060757152
chromatin	CNOT6L_4	chr4_77720488_T_G,chr4_77819455_A_C,chr4_77720486_A_G,chr4_77726534_A_C	0.003413275456645043,0.004884718330098437,1.3017900050261066e-05,0.013675885143940456	0.00045440611666765506,0.0041059419980858354,0.003812687853894012,0.002323583718729919
chromatin	SNX24_2	chr5_122845530_G_A,chr5_123023772_TA_T	0.003825812212204896,0.005412166991196986	0.032851178784777335,0.010215103992736332
chromatin	SQSTM1_4	chr5_179833153_C_T,chr5_179833213_G_A,chr5_179822433_T_C,chr5_179832842_G_C	0.004089948495769615,0.007896407107059047,1.0391418374918043e-11,5.901642675392869e-07	0.014656854055438881,0.015290841042493631,0.0024949336391905503,0.0024314650981475784
chromatin	CTTN_7	chr11_70419876_A_C,chr11_70419880_T_C,chr11_70433755_A_G,chr11_70433765_G_C,chr11_70407283_C_T,chr11_70433037_T_G,chr11_70435435_C_T	0.004793877560857165,0.0029267237988671235,0.0002662301400632249,2.1853977605406948e-05,5.710606729324503e-07,0.00010373335018763256,0.002764146814493288	0.00030309409522359497,0.003131141961303907,0.02047999046614251,0.008528354106314544,0.005941149857145408,0.004388396641544275,0.013709818259161087
chromatin	KDM2B_4	chr12_121580903_A_C,chr12_121579943_C_CA,chr12_121444386_T_G,chr12_121580252_TG_T	0.004804220239616889,5.298915204579247e-06,7.807472174797022e-08,0.024172279934987287	0.04290936139558865,0.01794421156168876,0.019501973878425127,0.004964292850525796
chromatin	CTNNA1_4	chr5_138812304_T_G,chr5_138824633_A_C,chr5_138933920_C_T,chr5_138812289_C_G	0.005041441550878414,0.009914746459480685,0.00032076772718977635,0.013542487211798218	0.013339032203366944,0.004284224604488671,0.00010488952235634391,0.0010251811268691103
chromatin	TRIOBP_2	chr22_37751927_A_C,chr22_37757383_C_G	0.0053165450762140245,0.0016386338499532257	0.008760146502383994,8.295724649894844e-05
chromatin	EGR1_2	chr5_138467153_A_C,chr5_138466811_A_C	0.005590395913285018,0.00018684738505679937	0.006707694887573882,0.00027393305226194143
chromatin	MYCBP2_8	chr13_77070727_G_A,chr13_77165156_A_T,chr13_77098982_T_G,chr13_77051091_G_A,chr13_77051098_A_C,chr13_77058230_T_G,chr13_77061586_T_C,chr13_77267898_T_G	0.008036895878308711,0.012181733375411912,0.0004449974043640469,0.0007742974469162077,0.004690941013903492,0.022811552981952272,0.0002327215378800939,0.004205585533754351	0.029852585169277374,0.00045980757332588846,0.0038229074053839733,0.00017518564876142542,4.397700485560215e-05,0.0032117224925540928,0.030373685856290068,0.00592396173483849
chromatin	TCF4_6	chr18_55464257_C_A,chr18_55463971_TGTGTGTGA_T,chr18_55275657_A_G,chr18_55275664_A_G,chr18_55403517_A_C,chr18_55461237_G_T	0.008090959269238968,0.0056178520760126974,0.001559758175866868,0.012472558742737408,0.0011862271176169732,0.006912522905586032	0.032420073593804284,0.03333184670009802,0.0013930308437610063,0.00619762753769391,1.5397131093463103e-06,0.04572000946513434
chromatin	LAMC1_3	chr1_183132309_A_C,chr1_183131203_C_T,chr1_183131172_CAA_C	0.008181813089040216,3.4320876665108484e-05,0.02745630451997897	0.01655294869349123,0.03400723316751987,0.002417084109353407
chromatin	DCBLD2_2	chr3_98800637_G_A,chr3_98822022_G_A	0.00885632710582371,0.003195091628487625	0.02405283820151249,0.02321925017861924
chromatin	FAM114A1_2	chr4_38905545_G_A,chr4_38905553_A_G	0.008914101428030875,9.057397575383816e-05	0.004385515653682114,0.0017226027017899913
chromatin	RXRA_2	chr9_134379472_C_A,chr9_134432274_T_C	0.01212893284996885,0.0010613625702847742	0.008306707838893354,0.02628295923936911
chromatin	TXNL4A_2	chr18_80033872_T_C,chr18_79988525_A_C	0.013055851849266827,0.0007334523399616647	0.0008431735834914795,0.0008431735834914795
chromatin	PLOD1_3	chr1_11957799_T_G,chr1_11958607_A_C,chr1_11949823_T_G	0.016423562694112787,0.0001256608005905079,0.00021455234639659347	0.008642421166450967,0.04289731210522306,0.033198246352540164
chromatin	ZBTB40_2	chr1_22508509_T_G,chr1_22490438_G_C	0.019306644087308318,0.0028404969140742	0.007412910007401148,0.034427044070664166
chromatin	LAMB1_4	chr7_107937003_CT_C,chr7_107937011_T_C,chr7_107932321_G_T,chr7_107962914_G_C	0.02001404015878396,0.03127808008490267,2.518001172595479e-05,0.001938778625683203	0.0036685711722291453,0.0056496711183904105,0.008417008915963444,0.03562871053322305
chromatin	ZNF407_2	chr18_74635526_T_C,chr18_74631665_A_C	0.02054827360868693,0.0027671214071800644	0.0030145474545959137,0.0007578348015755224
chromatin	PLK2_2	chr5_58457156_TA_T,chr5_58459186_CA_C	0.02678606136810066,0.011492772698233265	0.0067079016563832035,0.009712841903254471
chromatin	ITGAV_6	chr2_186622542_G_T,chr2_186637080_T_G,chr2_186637084_A_G,chr2_186602110_C_T,chr2_186665096_ATTT_A,chr2_186665096_ATTT_AT	0.02893229553935201,1.7690277512995773e-05,5.7650114136378393e-05,0.0008794014178128033,0.0009612996704148748,0.0001992070205841996	0.0007084667177580308,0.001139110475330106,0.032143834630956734,0.02901306245899837,0.02901306245899837,0.044847327779240435
chromatin	TPP2_4	chr13_102649187_G_T,chr13_102654868_C_T,chr13_102663598_G_C,chr13_102663763_G_A	0.03448812010250688,0.0477208297438401,0.019367023504440688,0.03879139461694567	0.0003388682906380855,0.0002674729630147893,5.0196213345567326e-05,0.0001694198597404117
chromatin	EGFR_2	chr7_55205133_G_A,chr7_55205662_A_C	0.03713506709789649,0.0018125796749231603	0.003745674667154008,0.0007797573368817686
chromatin	FAM57A_2	chr17_733080_T_TCTC,chr17_733026_A_AGGGCC	0.039798318296646464,0.015321230586696297	0.00016240672631849488,4.5958865963508443e-05
chromatin	RBFOX1_2	chr16_7676807_A_C,chr16_7653705_T_G	1.089283918433845e-06,0.009933638723622762	0.017746981967786752,0.040139058541755146
chromatin	PLEC_10	chr8_143935900_T_G,chr8_143916360_A_G,chr8_143917054_T_G,chr8_143917234_T_G,chr8_143918739_A_C,chr8_143919099_A_G,chr8_143925385_A_C,chr8_143919088_C_G,chr8_143927138_G_A,chr8_143930017_C_T	1.2060887811693293e-09,0.0045339553290741135,0.000104533588224814,1.7757593439950334e-05,0.00011641011921845986,1.9686417676937634e-05,0.006102754107095385,0.01695040934478527,0.039180192965724406,0.017591680187249745	0.0004960012901022363,0.00910116635228719,0.025072704488480143,0.013279688389245713,2.138708286444241e-05,0.0010288222361061275,0.0062995698781779215,0.009415988048366521,0.008162873576760793,0.001268625363946227
chromatin	ACTN1_2	chr14_68904620_A_G,chr14_68879945_C_A	2.2790061519900746e-05,0.002826959920374089	0.01924890787722053,0.03820518094606298
chromatin	YES1_2	chr18_724697_A_C,chr18_732727_A_G	2.3090624801719088e-05,0.007129044591559579	0.008883311549914912,0.026256278963938562
chromatin	SMARCC1_2	chr3_47662444_T_G,chr3_47735913_C_T	2.3383243293118917e-06,0.002421910157609216	0.0017680794934126945,0.01814701077813162
chromatin	LMNA_2	chr1_156139242_AT_A,chr1_156138783_A_G	2.3951192128687798e-05,0.0022551444971150103	0.04237931129547261,0.040758441980734486
chromatin	CCND1_2	chr11_69650913_A_G,chr11_69651969_C_G	2.86821845503723e-06,0.0004216841283241181	0.024298615321604846,0.021515769887785408
chromatin	SMARCA4_3	chr19_11025539_C_G,chr19_11025639_C_T,chr19_11059900_G_C	3.0403566208171576e-05,9.60336281664007e-06,0.00028978302130045137	0.00029624992802644123,0.02706216606857304,0.035243495124704975
chromatin	KMT2C_7	chr7_152273692_G_A,chr7_152235860_C_T,chr7_152145265_T_G,chr7_152152848_C_A,chr7_152177504_T_G,chr7_152236218_G_A,chr7_152152869_A_G	4.1091183934080156e-05,0.03814263508657298,0.010803753158495692,0.018128565763915704,0.001183790631102062,0.008327722660599219,0.017441444102837326	0.02044755694417402,0.00015664974968742393,0.0030671124260532785,0.00028670765106413883,0.0007976241891358237,0.0009326888762057726,0.008191480303636886
chromatin	PXN_2	chr12_120219856_A_C,chr12_120219864_A_C	4.578278108445838e-05,0.0074220837424624425	0.0003630643828121584,0.0023389819820739933
chromatin	BCOR_2	chrX_40052275_A_C,chrX_40074609_T_G	4.939704915952993e-09,0.0027449638737320047	0.00020414397606395237,0.02744186131378764
chromatin	FLI1_2	chr11_128810729_A_G,chr11_128810736_G_C	5.306393173162265e-05,0.004212940238900314	1.6562593178924343e-05,1.4658089385344776e-05
chromatin	LAMB2_4	chr3_49121431_A_C,chr3_49126013_T_G,chr3_49125146_T_G,chr3_49121239_T_G	5.5170807525836925e-05,0.03902097870402451,7.419230761410297e-05,0.003164093062093864	2.9470349723526757e-05,0.002569958840604656,0.002569958840604656,0.028556312248339717
chromatin	HMGA2_2	chr12_65841991_CT_C,chr12_65838525_G_A	5.57550946086e-05,0.039914434884169736	0.032926686839147117,0.00575414262140414
chromatin	ZNF708_3	chr19_21294577_C_T,chr19_21309149_T_A,chr19_21309260_G_A	5.694223127781568e-05,9.010844850080123e-06,0.0003481251422158083	0.007544201865148675,0.008126720123629898,4.891895383413758e-05
chromatin	ASPH_2	chr8_61578734_T_G,chr8_61578968_A_C	6.56790692451237e-08,0.0009758798617439217	0.00027481062695969863,0.0029272870469332557
chromatin	CCAR1_5	chr10_68737016_C_A,chr10_68736998_A_C,chr10_68747386_A_C,chr10_68749170_A_C,chr10_68747145_CT_C	8.229773536774104e-06,0.007146867657347806,0.0011117731660420908,0.0013852137674061765,0.003664158474067453	0.003954046326130957,0.005283569468845993,0.002868590533518923,0.044268019704288585,0.007417608363424872
chromatin	DOCK1_3	chr10_127008567_ATAACT_A,chr10_127248024_G_T,chr10_127414990_T_G	9.077419985352092e-05,0.0002745710836507499,0.00705137247255559	0.0011610761862802675,0.020184142497530616,0.047170945666414485

EGFR signaling 약물에 대한 반응성 바이오 마커

Drug_Class	Gene_exp	바이오마커 ( 발현조절변이세트 )
egfr	Gene_EXP:ACLY	15_26976868_T_A
egfr	Gene_EXP:ACSF2	2_71393433_A_G,2_71424561_G_GT,2_71428456_T_A,2_71433365_T_TC
egfr	Gene_EXP:ADTRP	4_20727343_G_C
egfr	Gene_EXP:AHI1	2_102664958_A_C
egfr	Gene_EXP:AIM1	11_124396830_G_A
egfr	Gene_EXP:AMN	12_52057489_T_C
egfr	Gene_EXP:ANO5	12_9427796_G_T
egfr	Gene_EXP:AP1M2	1_168044966_T_A,8_17562030_G_A,6_31112217_C_T,6_31138682_C_A,1_2491175_G_A
egfr	Gene_EXP:APBB1	7_117548606_ATG_A
egfr	Gene_EXP:ATP10B	3_123931600_TAA_TA,14_19303535_T_C,17_39709512_T_C
egfr	Gene_EXP:ATP6V0B	17_78529723_C_G
egfr	Gene_EXP:AVPI1	3_157413999_A_C
egfr	Gene_EXP:BARX2	3_101857038_T_C
egfr	Gene_EXP:C12orf57	1_103082763_C_G
egfr	Gene_EXP:C16orf45	1_151848276_A_C,6_46140015_C_G,6_46161608_G_A,6_46167752_T_C,6_46168247_G_T
egfr	Gene_EXP:C1orf116	3_129272155_T_C
egfr	Gene_EXP:C3orf52	3_111919285_A_C,3_101857038_T_C,10_1020770_C_T
egfr	Gene_EXP:CAMSAP3	12_14460981_T_A,19_9985806_C_T,19_9986005_G_A
egfr	Gene_EXP:CAV1	10_133626829_C_T
egfr	Gene_EXP:CCND3	7_151221500_CT_C,14_68477626_CT_C
egfr	Gene_EXP:CDH3	7_140753336_A_T
egfr	Gene_EXP:CDK13	1_26457907_T_G,22_30937565_T_G
egfr	Gene_EXP:CDK6	6_31662176_A_G,6_31662464_C_T
egfr	Gene_EXP:CEBPD	6_150926303_A_G
egfr	Gene_EXP:CENPM	19_10793898_A_C
egfr	Gene_EXP:CES2	8_17085328_C_T
egfr	Gene_EXP:CHGB	15_67236036_T_G
egfr	Gene_EXP:CHN1	17_81206909_A_C
egfr	Gene_EXP:CLIP3	5_163482681_G_A
egfr	Gene_EXP:CNPY4	17_48728228_G_A
egfr	Gene_EXP:CRB3	20_32983679_C_T
egfr	Gene_EXP:CRYBA2	17_19742625_A_C
egfr	Gene_EXP:CYB561	17_75618277_G_A,17_75620366_A_T
egfr	Gene_EXP:DAPP1	13_113835487_C_T,18_70325196_C_T,19_56053761_G_A
egfr	Gene_EXP:DDR1	2_174801578_A_G,4_89936328_G_A
egfr	Gene_EXP:DDX25	2_61492168_C_A,5_181155466_T_G,7_72942379_A_C,11_43920052_A_C,12_40313960_G_T
egfr	Gene_EXP:DDX60L	6_143772215_C_T
egfr	Gene_EXP:DENND5A	16_14764032_A_G
egfr	Gene_EXP:DNMT3A	22_36566306_C_G
egfr	Gene_EXP:DPY19L3	15_65564315_G_A,17_78425362_G_A,17_78427070_C_T
egfr	Gene_EXP:DQX1	1_113907966_C_T
egfr	Gene_EXP:DSC3	11_18285498_T_C,11_18311889_A_T
egfr	Gene_EXP:DTX3L	4_185267219_TA_T
egfr	Gene_EXP:DYNC1LI1	12_56346229_GAGA_G
egfr	Gene_EXP:EGFR	1_16027940_A_T,1_16048568_C_G
egfr	Gene_EXP:EMP3	16_14764032_A_G,17_75620366_A_T
egfr	Gene_EXP:EPSTI1	2_226796327_T_C
egfr	Gene_EXP:ERBB2	1_225042906_C_T,1_225085546_G_T
egfr	Gene_EXP:ERO1L	6_47579334_T_TAA
egfr	Gene_EXP:ESRP1	20_32983679_C_T
egfr	Gene_EXP:EVPL	15_84798628_G_A
egfr	Gene_EXP:FAM136A	1_16048568_C_G,16_50711362_A_C
egfr	Gene_EXP:FAT2	19_15807367_G_T
egfr	Gene_EXP:FGFBP1	2_65069680_A_C,17_81206909_A_C
egfr	Gene_EXP:FRMD4B	20_32983679_C_T
egfr	Gene_EXP:FXYD3	1_110407655_G_A,16_1210969_G_A,9_88647579_G_T,22_50625559_G_C,10_103724260_T_C
egfr	Gene_EXP:FZD3	1_26457907_T_G
egfr	Gene_EXP:GALNT3	3_7680310_G_A,6_150945502_T_G
egfr	Gene_EXP:GBP1	3_55480738_A_T
egfr	Gene_EXP:GJB2	1_44978366_G_A
egfr	Gene_EXP:GJB3	6_129475475_C_T,17_7461905_T_G,20_32983679_C_T
egfr	Gene_EXP:GJB5	6_129475475_C_T,16_16349121_A_G,20_32983679_C_T
egfr	Gene_EXP:GJB6	1_44978366_G_A
egfr	Gene_EXP:GLTP	2_182994745_T_C
egfr	Gene_EXP:GNAQ	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
egfr	Gene_EXP:GNB3	X_135719129_C_T
egfr	Gene_EXP:GPC1	1_54243266_A_G,10_74988957_T_G,7_75364819_A_C,17_7797836_A_C,3_113344632_A_C
egfr	Gene_EXP:GPC1	3_184278425_C_T
egfr	Gene_EXP:GPR87	19_15807367_G_T
egfr	Gene_EXP:GRB7	7_152648922_C_T
egfr	Gene_EXP:GRHL2	20_32983679_C_T
egfr	Gene_EXP:GYLTL1B	7_5938011_C_CCA,7_5945090_C_T
egfr	Gene_EXP:HSD17B10	5_24511259_C_T
egfr	Gene_EXP:ICAM1	8_12358868_A_G
egfr	Gene_EXP:IFIT3	18_50806833_C_G
egfr	Gene_EXP:IFIT5	6_169632990_G_A,6_169665646_G_A
egfr	Gene_EXP:IGSF9	11_27340812_T_G,14_21082261_T_G,19_12690012_T_G
egfr	Gene_EXP:INADL	2_241246976_C_T,3_58285236_T_C,16_75166518_T_C
egfr	Gene_EXP:ITGA6	9_111758806_C_T,12_6952191_A_C
egfr	Gene_EXP:JAG2	1_1971961_T_G,7_48043449_T_G
egfr	Gene_EXP:JSRP1	15_22573256_T_G
egfr	Gene_EXP:KCTD18	9_60935641_T_G
egfr	Gene_EXP:KLC3	20_32983679_C_T
egfr	Gene_EXP:KLK6	4_48170201_C_T,4_48170249_G_A
egfr	Gene_EXP:KLRG1	21_42543649_A_G,21_42565845_G_A
egfr	Gene_EXP:KRT5	3_10200303_A_C
egfr	Gene_EXP:KRT6A	22_50576781_G_C
egfr	Gene_EXP:LAD1	11_118555347_C_A
egfr	Gene_EXP:LAD1	19_12528668_A_C
egfr	Gene_EXP:LAMC2	18_63659363_A_C,18_63659368_A_G
egfr	Gene_EXP:LEPRE1	1_205849911_C_T,1_205849976_G_A,4_68337362_T_C,4_182680440_G_C,4_182680513_G_A
egfr	Gene_EXP:LEPRE1	20_32983679_C_T
egfr	Gene_EXP:LRRC1	1_156743766_G_A
egfr	Gene_EXP:LRRC8A	5_173158713_A_G
egfr	Gene_EXP:MAD2L2	7_117548606_ATG_A
egfr	Gene_EXP:MAN1B1	19_57455681_G_T,19_57455765_G_A,19_57473550_A_G,19_57490144_T_A,19_57507480_A_G
egfr	Gene_EXP:MCTP2	4_99216165_A_T
egfr	Gene_EXP:MICALL1	22_36566306_C_G
egfr	Gene_EXP:MLKL	17_80137479_A_T
egfr	Gene_EXP:MMRN2	19_15807367_G_T
egfr	Gene_EXP:MPHOSPH9	14_104949986_T_C
egfr	Gene_EXP:MPP1	7_114663562_CT_C,9_33796659_C_T,9_33798019_A_G
egfr	Gene_EXP:MYT1	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G
egfr	Gene_EXP:MZT1	10_31363289_T_C
egfr	Gene_EXP:NCAPD3	17_8881770_A_C,17_8881775_C_T
egfr	Gene_EXP:NR2F6	1_231795302_T_C,2_97167816_C_T,7_144232341_G_C,17_81460232_G_A,19_51014792_C_T
egfr	Gene_EXP:NUDC	18_24064127_G_T
egfr	Gene_EXP:OTUD1	3_128992964_T_G
egfr	Gene_EXP:OVOL1	15_22608045_C_A
egfr	Gene_EXP:P2RY2	5_169294_T_C,17_60211184_A_G
egfr	Gene_EXP:P2RY6	2_71398637_G_A,2_71399439_CTA_C,2_71418498_G_GT,2_71424561_G_GT
egfr	Gene_EXP:PAICS	19_50637249_G_A
egfr	Gene_EXP:PARP12	22_36566306_C_G
egfr	Gene_EXP:PARP9	4_185267219_TA_T
egfr	Gene_EXP:PBX3	5_19503134_C_A,9_17273880_A_G,9_33062185_G_GA
egfr	Gene_EXP:PCSK1N	15_74801109_A_C
egfr	Gene_EXP:PDLIM1	11_124186080_G_A,11_124224942_C_A
egfr	Gene_EXP:PDP1	4_87811722_A_G,15_25189495_C_T,15_25189608_A_G,15_25199636_G_A
egfr	Gene_EXP:PEX13	10_98209718_A_C,10_98236016_C_T,10_98253681_C_T
egfr	Gene_EXP:PIAS2	18_49837560_A_G,18_49837561_G_C
egfr	Gene_EXP:PITPNM3	6_42916173_G_C
egfr	Gene_EXP:PLD2	15_84407910_G_A
egfr	Gene_EXP:PLEKHA1	16_89546571_ACC_AC
egfr	Gene_EXP:PLP2	16_24862746_A_C
egfr	Gene_EXP:PNPLA6	11_122808020_A_G,14_92651884_C_T,16_14764032_A_G
egfr	Gene_EXP:PPP1R13L	7_33099535_G_A
egfr	Gene_EXP:PPP1R14C	7_64336444_AT_A
egfr	Gene_EXP:PPP1R14C	12_27658716_G_T
egfr	Gene_EXP:PRAF2	16_14764032_A_G,16_46710765_T_A,16_54284260_C_A
egfr	Gene_EXP:PRDM15	5_181333681_C_T
egfr	Gene_EXP:PRSS8	18_77066283_A_G,18_77066289_G_A
egfr	Gene_EXP:PTAFR	9_132827103_T_C
egfr	Gene_EXP:PTBP3	11_89798633_CA_C
egfr	Gene_EXP:PTGFRN	5_126804830_T_C,5_126836282_C_T,11_1250937_C_T
egfr	Gene_EXP:PTGS2	11_86556636_G_A,11_86559642_C_T
egfr	Gene_EXP:PTP4A3	X_92201459_T_G
egfr	Gene_EXP:PTPRO	1_169725777_A_G,1_169727805_G_A
egfr	Gene_EXP:PYHIN1	18_63399230_A_G
egfr	Gene_EXP:RAB2B	15_20251568_G_A
egfr	Gene_EXP:RASEF	2_11596179_G_A,2_131600094_A_G
egfr	Gene_EXP:RHBDL2	5_100389692_A_C,5_150068208_G_A
egfr	Gene_EXP:RHOV	1_1971961_T_G
egfr	Gene_EXP:RIC8B	3_39412024_A_G
egfr	Gene_EXP:RNF208	4_7815971_GT_G,19_11832898_G_A
egfr	Gene_EXP:RNFT2	22_36566306_C_G
egfr	Gene_EXP:ROR2	6_6305225_G_C,13_44436731_C_T
egfr	Gene_EXP:RUNX1	9_33796659_C_T,9_33796705_C_G
egfr	Gene_EXP:RXRA	15_30087620_G_A,15_32400109_G_A
egfr	Gene_EXP:S100A11	11_124145287_C_T
egfr	Gene_EXP:S100A7	15_80159671_C_T
egfr	Gene_EXP:S100A8	19_7746529_A_C
egfr	Gene_EXP:SDC1	14_70246869_T_G
egfr	Gene_EXP:SEC61G	19_2073455_A_C
egfr	Gene_EXP:SERINC3	2_25980839_T_G
egfr	Gene_EXP:SERPINB13	6_43139226_A_C,20_32917383_C_T,20_32930492_A_G,20_32983679_C_T
egfr	Gene_EXP:SERPINB5	22_50625559_G_C
egfr	Gene_EXP:SFXN3	10_68691523_T_C
egfr	Gene_EXP:SGCB	8_105802428_G_C,12_50109486_C_T
egfr	Gene_EXP:SGTB	10_98209718_A_C,10_98236016_C_T,10_98253681_C_T
egfr	Gene_EXP:SH2D3A	6_129475475_C_T
egfr	Gene_EXP:SLC15A2	2_174801578_A_G
egfr	Gene_EXP:SLC37A2	6_70302872_T_C
egfr	Gene_EXP:SLC9A3R1	15_75783322_C_G
egfr	Gene_EXP:SNAP25	2_71424561_G_GT
egfr	Gene_EXP:SOX15	18_12840880_T_C
egfr	Gene_EXP:SPAG1	3_151328520_G_A,17_50192542_A_G
egfr	Gene_EXP:SSH3	3_7680310_G_A
egfr	Gene_EXP:ST18	10_133626012_T_A,10_133626013_G_A
egfr	Gene_EXP:ST6GALNAC2	4_54263987_G_A,6_31666781_A_G,6_136659286_G_A,6_150945502_T_G
egfr	Gene_EXP:STRA13	12_878316_G_A
egfr	Gene_EXP:SYNC	15_42142087_A_C
egfr	Gene_EXP:TEAD3	18_166710_TTAAAA_T,18_166819_T_C,18_264012_G_A
egfr	Gene_EXP:TEX30	10_31363289_T_C
egfr	Gene_EXP:THBS1	15_65447029_G_A
egfr	Gene_EXP:TIGD3	5_135888024_G_T
egfr	Gene_EXP:TMPRSS15	21_39898596_C_A
egfr	Gene_EXP:TMPRSS4	11_18484085_G_A
egfr	Gene_EXP:TNFAIP8	17_16624481_C_A
egfr	Gene_EXP:TNNT3	2_226796327_T_C
egfr	Gene_EXP:TP63	20_32983679_C_T
egfr	Gene_EXP:TRAF4	10_128101658_T_C
egfr	Gene_EXP:TRIM21	18_50806833_C_G
egfr	Gene_EXP:TRIM29	11_45181661_C_T,20_32983679_C_T
egfr	Gene_EXP:TRIP6	17_78529677_G_C
egfr	Gene_EXP:TSR2	8_109271027_T_C,8_109271124_T_G
egfr	Gene_EXP:TTC3	12_66128870_G_A
egfr	Gene_EXP:UBAP1	5_31510999_G_T
egfr	Gene_EXP:UBASH3B	14_68477626_CT_C
egfr	Gene_EXP:UFM1	8_7811967_A_G
egfr	Gene_EXP:VIM	16_14764032_A_G
egfr	Gene_EXP:VTI1B	2_225401003_CTGG_C
egfr	Gene_EXP:WDR85	17_6755950_T_G
egfr	Gene_EXP:WNT10A	6_129475475_C_T
egfr	Gene_EXP:ZEB1	3_58285236_T_C,9_41905830_C_G
egfr	Gene_EXP:ZFP82	3_33120406_C_T
egfr	Gene_EXP:ZNF546	14_23360749_G_A,14_65267030_C_T,14_92651884_C_T
egfr	Gene_EXP:ZNF750	19_15794719_C_A,19_15807367_G_T

[표 19]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value) 및 약물과의 상관도(P-value)를 산출한 결과가 아래 [표 20]에 정리되어있다.

또한, [표 19]에 제시된 FRH들이 포함되어 발현된 유전자들 중 주요 유전자와 각각의 EGFR 약물과의 상관도(P-value)를 산출한 결과가 도 33에 도시되어 있다.

이들 [표 20] 및 [도 33]로부터 [표 20] 및 [도 33]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 EGFR 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

DrugPathway	GENE	Variants	Var _Drug( pval )	Var _ Exp ( Pval )
egfr	CWC27_1	chr5_64977191_G_A	2.20E-08	0.002090721
egfr	RNF217_1	chr6_125082793_A_C	3.96E-08	0.0374208
egfr	PTGR1_1	chr9_111597344_C_A	8.25E-08	2.15E-05
egfr	NTN4_1	chr12_95738117_A_G	1.53E-07	0.019702457
egfr	ZNF276_1	chr16_89737928_T_C	1.72E-07	0.019670045
egfr	THBS1_1	chr15_39587486_A_C	2.59E-07	0.031233094
egfr	TRIM29_1	chr11_120115474_C_A	3.52E-07	0.011023929
egfr	APBB1_1	chr11_6401118_A_C	7.48E-07	0.04449344
egfr	RASA3_1	chr13_113981629_G_A	1.35E-06	0.009453296
egfr	TMX3_1	chr18_68700489_TA_T	1.39E-06	0.003224589
egfr	RRP1_1	chr21_43791417_C_A	1.65E-06	0.034182877
egfr	SIT1_1	chr9_35650461_G_A	1.75E-06	0.019947873
egfr	FRG1_1	chr4_189955114_T_C	2.25E-06	0.018901776
egfr	GTF2IRD1_1	chr7_74512993_A_G	3.54E-06	0.006481631
egfr	DCP1A_1	chr3_53342054_G_C	4.78E-06	0.003471409
egfr	SNRNP70_1	chr19_49101556_A_C	5.20E-06	0.016599779
egfr	DDX20_1	chr1_111756207_T_C	5.26E-06	0.008003234
egfr	TJP2_1	chr9_69237088_T_C	5.58E-06	0.04386431
egfr	RHOJ_1	chr14_63269236_T_G	6.18E-06	0.027885215
egfr	CXCL2_1	chr4_74098975_A_C	7.13E-06	0.000838562
egfr	CARD8_1	chr19_48212012_T_C	9.03E-06	0.00020501
egfr	TRMT2A_1	chr22_20117296_A_C	9.03E-06	0.048556634
egfr	CRIM1_1	chr2_36479368_G_C	9.53E-06	0.012444715
egfr	ELF3_1	chr1_202010991_C_G	9.65E-06	0.017391595
egfr	UHRF2_1	chr9_6482002_G_T	1.20E-05	0.007025127
egfr	HDHD2_1	chr18_47115026_C_T	1.42E-05	1.48E-06
egfr	ZBTB17_1	chr1_15944765_G_A	1.47E-05	0.010171388
egfr	THRB_1	chr3_24143504_G_A	1.80E-05	0.026515077
egfr	DHRS3_1	chr1_12568430_G_A	1.81E-05	0.043238329
egfr	AGTPBP1_1	chr9_85672687_TA_T	1.94E-05	0.017580094
egfr	DMTF1_1	chr7_87166631_TAG_T	1.97E-05	0.010040428
egfr	CTBP2_1	chr10_124993226_T_G	2.02E-05	0.022707139
egfr	BLK_1	chr8_11543171_G_A	2.24E-05	0.01145612
egfr	EPCAM_1	chr2_47373742_AT_A	2.57E-05	0.033377716
egfr	JUN_1	chr1_58782229_T_C	2.65E-05	0.037758558
egfr	RBM5_1	chr3_50114164_G_T	2.77E-05	0.00111984
egfr	CDKN2AIP_1	chr4_183445476_T_TGCACA	2.77E-05	0.002734488
egfr	ZCCHC7_1	chr9_37302158_C_T	2.93E-05	0.022389727
egfr	RAB8B_1	chr15_63262625_GTA_G	2.96E-05	0.020562837
egfr	ODC1_1	chr2_10444350_A_C	2.98E-05	0.031377929
egfr	CLTB_1	chr5_176397682_T_C	3.11E-05	0.006127908
egfr	UIMC1_1	chr5_176906125_C_T	3.66E-05	0.014840456
egfr	HCST_1	chr19_35903545_A_C	3.71E-05	0.031562304
egfr	HSPA1B_1	chr6_31828722_C_G	3.82E-05	0.018774385
egfr	MYL12B_1	chr18_3261766_G_T	4.16E-05	0.002628021
egfr	RHBDF1_1	chr16_63885_G_GCC	4.21E-05	0.04101508
egfr	UBE2N_1	chr12_93411182_C_T	4.29E-05	1.51E-06
egfr	SVIL_1	chr10_29524582_A_G	4.44E-05	0.010981597
egfr	CCDC28B_1	chr1_32202026_A_C	4.45E-05	0.031117706
egfr	ADARB1_1	chr21_45182568_CT_C	4.48E-05	0.049945862
egfr	PPP4R1_1	chr18_9549876_A_G	5.09E-05	0.004893788
egfr	CHD1L_1	chr1_147294440_C_G	5.10E-05	0.048656291
egfr	LRP5_1	chr11_68424878_T_G	5.20E-05	0.010363624
egfr	RND3_1	chr2_150487464_GA_G	5.77E-05	0.009852344
egfr	LONRF1_1	chr8_12731670_C_A	5.98E-05	0.001411904
egfr	BCOR_1	chrX_40052275_A_C	6.09E-05	0.000204144
egfr	CCT8_1	chr21_29070160_C_T	6.54E-05	0.02571665
egfr	ZNF330_1	chr4_141232702_CTT_C	8.61E-05	0.012329326
egfr	CEP128_1	chr14_80916501_C_A	8.82E-05	0.001156052
egfr	SH2D3A_1	chr19_6760997_A_G	9.99E-05	0.028745239
egfr	IRF6_1	chr1_209790735_C_T	0.000103095	0.008136801
egfr	ITGAL_1	chr16_30484175_C_T	0.000109049	0.037227837
egfr	UEVLD_1	chr11_18558312_C_A	0.000112934	0.026771319
egfr	RNF141_1	chr11_10530725_T_C	0.000116417	0.011923468
egfr	THRAP3_1	chr1_36288866_G_C	0.000117571	0.000131738
egfr	PIAS4_1	chr19_4028785_C_T	0.000120052	0.024864531
egfr	SLC22A5_1	chr5_132390655_C_A	0.000123083	0.004292176
egfr	JAG1_1	chr20_10648877_T_C	0.00012714	0.02148436
egfr	SPI1_1	chr11_47358510_A_C	0.000133865	0.03491009
egfr	TECPR1_1	chr7_98223587_A_G	0.000136841	0.023100583
egfr	ZC3HC1_1	chr7_130023656_C_T	0.000136956	0.010175357
egfr	PDGFA_1	chr7_518698_G_C	0.000139135	0.000252407
egfr	C16orf74_1	chr16_85741569_G_A	0.000148491	0.001823033
egfr	DOT1L_1	chr19_2226677_G_A	0.00015451	0.006191812
egfr	CD19_1	chr16_28937656_A_C	0.000155088	0.031114669
egfr	P2RY2_1	chr11_73235099_G_C	0.000158117	0.045669577
egfr	EHF_1	chr11_34661000_T_C	0.000158117	0.017992198
egfr	EPS15L1_1	chr19_16392488_A_C	0.000158117	0.033272384
egfr	AGTRAP_1	chr1_11750007_T_G	0.000159275	0.049159238
egfr	LYRM7_1	chr5_131199511_CT_C	0.000164473	0.021278948
egfr	EPAS1_1	chr2_46346944_T_G	0.000170063	0.018667654
egfr	SIX4_1	chr14_60713618_C_T	0.000180476	0.049844478
egfr	PROM2_1	chr2_95281185_T_G	0.000190311	0.033838771
egfr	CAPN1_1	chr11_65186241_T_G	0.000194914	0.02936405
egfr	SRRM1_1	chr1_24669380_C_A	0.000202713	0.019718891
egfr	KLF3_1	chr4_38689006_A_C	0.000228896	0.015121455
egfr	THSD4_1	chr15_71765130_A_C	0.000239788	1.95E-06
egfr	GPR107_1	chr9_130129853_A_G	0.000243505	0.033022802
egfr	TCERG1_1	chr5_146471685_A_C	0.000246294	0.042046343
egfr	ATG4C_1	chr1_62805167_G_T	0.000259178	0.028589986
egfr	SHQ1_1	chr3_72750552_C_T	0.000259737	0.005940284
egfr	DSG2_1	chr18_31524751_A_G	0.000261765	0.009944093
egfr	S100A14_1	chr1_153615226_C_T	0.000274681	0.01787459
egfr	CLDN4_1	chr7_73830773_C_T	0.000293995	0.000682466
egfr	OVOL2_1	chr20_18041767_A_G	0.000295117	0.047118131
egfr	CREB1_1	chr2_207577759_AT_A	0.00029854	0.000463006
egfr	BCLAF1_1	chr6_136278266_T_C	0.000301864	6.60E-05
egfr	PKP2_1	chr12_32791480_G_T	0.000343509	0.006486331
egfr	ADAM9_1	chr8_39082624_ATTT_A	0.000344695	0.022961
egfr	POLA1_1	chrX_24743203_T_G	0.000351661	0.028975018
egfr	FBXO10_1	chr9_37537560_G_A	0.000376887	0.024540631
egfr	CHMP4B_1	chr20_33811394_C_G	0.000388769	0.00409862
egfr	NOP56_1	chr20_2657708_GT_G	0.000405654	0.000313483
egfr	WIPF1_1	chr2_174585550_T_G	0.000407518	0.000483959
egfr	SCNN1A_1	chr12_6349108_G_C	0.00042455	0.003465155
egfr	C11orf80_1	chr11_66828178_C_T	0.000427492	0.010017428
egfr	ERP27_1	chr12_14914577_T_TGTGC	0.000433389	0.018734323
egfr	JAG2_1	chr14_105151295_T_G	0.000452695	0.00756224
egfr	SMARCC1_1	chr3_47693210_A_G	0.00046021	6.92E-05
egfr	RNF138_1	chr18_32123591_T_C	0.000469129	0.018606829
egfr	THYN1_1	chr11_134248640_G_T	0.000477172	0.042214253
egfr	CYP24A1_1	chr20_54164725_T_C	0.000480706	0.013922674
egfr	SH2D3C_1	chr9_127766923_A_C	0.000489816	0.042455713
egfr	TGFA_1	chr2_70453242_T_G	0.000497539	0.011508647
egfr	CXCL16_1	chr17_4738773_T_G	0.000507631	0.000457547
egfr	AEN_1	chr15_88629905_A_C	0.000523617	0.014580971
egfr	SLC37A1_1	chr21_42534616_T_G	0.00054592	0.025393921
egfr	EPHA2_1	chr1_16148437_A_C	0.000564393	0.003022958
egfr	BCS1L_1	chr2_218660859_A_G	0.000567546	0.011564609
egfr	FBXO43_1	chr8_100137711_G_C	0.000602338	0.026281824
egfr	ADAM22_1	chr7_88075657_C_T	0.000632153	0.041287227
egfr	ADAMTSL1_1	chr9_18636052_G_T	0.000649915	0.010200615
egfr	ATXN2L_1	chr16_28834263_C_T	0.000652099	0.023519932
egfr	ZCCHC4_1	chr4_25313024_A_C	0.000669769	0.022993547
egfr	BCL2_1	chr18_63318646_T_C	0.000676626	0.021320439
egfr	EGR1_1	chr5_138466811_A_C	0.000686817	0.000273933
egfr	HS3ST1_1	chr4_11399218_T_C	0.000704542	0.027639734
egfr	LEF1_1	chr4_108078210_G_A	0.000716837	0.012727304
egfr	SRSF7_1	chr2_38748190_GT_G	0.000734347	0.005863144
egfr	KHSRP_1	chr19_6415784_T_C	0.000787917	0.003576751
egfr	YPEL1_1	chr22_21704297_T_C	0.000796764	0.006311112
egfr	TAPT1_1	chr4_16162866_G_A	0.000802167	0.000763967
egfr	SNRK_1	chr3_43348277_C_T	0.000817875	0.00952899
egfr	UGCG_1	chr9_111932206_A_G	0.000846657	0.012775358
egfr	DBF4B_1	chr17_44709262_G_C	0.000856709	0.025236345
egfr	HOOK1_1	chr1_59860373_C_G	0.000856894	0.041888498
egfr	ITGB3BP_1	chr1_63572436_G_T	0.000871324	0.023830002
egfr	DTX4_1	chr11_59205028_T_C	0.000886385	0.025332013
egfr	PPP1R13L_1	chr19_45391868_T_C	0.000894105	0.005877508
egfr	CBLC_1	chr19_44790103_A_C	0.000937082	0.025305244
egfr	B4GALT4_1	chr3_119212822_G_T	0.000987069	8.97E-06
egfr	HSBP1_1	chr16_83809462_C_T	0.000990234	0.008673739
egfr	DTX1_1	chr12_113093500_A_T	0.001029524	0.02107386
egfr	TMEM51_1	chr1_15219789_A_C	0.001061315	0.004570596
egfr	ASAP2_1	chr2_9388476_A_C	0.001065564	0.013740425
egfr	PPP2R3C_1	chr14_35096667_C_A	0.001070573	0.008848084
egfr	WWC2_1	chr4_183280995_G_T	0.001131955	0.017164588
egfr	DMKN_1	chr19_35505819_C_T	0.001187435	0.023762682
egfr	EPHX1_1	chr1_225838589_T_G	0.001193048	0.015600736
egfr	PRPF4B_1	chr6_4051933_C_A	0.001231599	0.023843897
egfr	SNRNP40_1	chr1_31267793_A_G	0.001239539	0.0334327
egfr	LTBP3_1	chr11_65543062_T_C	0.00124246	0.027887632
egfr	BAG3_1	chr10_119651803_A_C	0.001254787	0.031179453
egfr	ANKRD2_1	chr10_97572685_T_G	0.001261251	0.014732168
egfr	ZNF451_1	chr6_57147971_C_A	0.001263762	0.000340137
egfr	ME2_1	chr18_50920583_C_T	0.00130336	2.53E-06
egfr	DLG5_1	chr10_77811963_T_G	0.001305738	0.016910687
egfr	USP19_1	chr3_49111457_T_C	0.001383111	0.008511689
egfr	PDCD11_1	chr10_103433899_A_G	0.001419074	0.023046171
egfr	PDE1B_1	chr12_54577030_T_G	0.0014774	0.000907902
egfr	LONP1_1	chr19_5707040_C_G	0.001478061	0.014919269
egfr	KCNN3_1	chr1_154733143_A_C	0.001483801	0.012755172
egfr	FSD1_1	chr19_4304543_G_C	0.001495716	0.036857163
egfr	F2RL1_1	chr5_76832874_T_G	0.001535054	0.000269192
egfr	XPO4_1	chr13_20787374_T_C	0.001546207	0.044182604
egfr	TM4SF1_1	chr3_149375342_T_G	0.001551483	0.005766355
egfr	NPAS1_1	chr19_47035965_T_G	0.001567313	0.037858765
egfr	FAM78A_1	chr9_131260861_G_A	0.001574494	0.029873205
egfr	SYTL2_1	chr11_85734802_A_C	0.001576085	0.007792297
egfr	TMEM57_1	chr1_25431052_T_G	0.001577095	0.001041181
egfr	TUBA1A_1	chr12_49186397_T_C	0.001584541	0.019746043
egfr	ITPR3_1	chr6_33692820_C_T	0.001625448	0.001333145
egfr	ATM_1	chr11_108317650_T_C	0.001633198	0.007926126
egfr	SGTA_1	chr19_2769109_A_C	0.001653712	0.041785185
egfr	LCORL_1	chr4_17883673_A_AAC	0.001662772	0.000314326
egfr	MTDH_1	chr8_97660911_G_GATA	0.001694886	0.048360283
egfr	IKBKB_1	chr8_42320656_T_C	0.00170984	2.52E-05
egfr	HNRNPD_1	chr4_82355277_C_CA	0.001737277	0.049911299
egfr	RAX_1	chr18_59272671_A_C	0.001739655	0.028250861
egfr	ZNF775_1	chr7_150397902_A_C	0.001751147	0.01910485
egfr	ALDH1A3_1	chr15_100885169_T_G	0.001758148	0.04003907
egfr	GNAI2_1	chr3_50252193_A_C	0.001785905	0.005183043
egfr	ZNF740_1	chr12_53187645_C_G	0.001788461	0.049202233
egfr	NTM_1	chr11_132307846_G_T	0.001796239	0.000193861
egfr	CHN1_1	chr2_174801578_A_G	0.001797358	0.038050415
egfr	PAX5_1	chr9_36923611_G_A	0.001934236	0.014759026
egfr	VAMP3_1	chr1_7781489_A_C	0.00200626	0.040313352
egfr	STK4_1	chr20_44995009_C_T	0.002049488	5.24E-05
egfr	USP24_1	chr1_55075675_C_A	0.002073268	0.008980628
egfr	EXOSC10_1	chr1_11080567_C_A	0.002083377	0.019692529
egfr	TINAGL1_1	chr1_31585380_T_G	0.002085646	0.037138102
egfr	SPTLC3_1	chr20_13093456_G_T	0.002145546	0.024467108
egfr	PLEKHA6_1	chr1_204257921_A_C	0.002162143	0.049362899
egfr	PLXNC1_1	chr12_94219931_T_G	0.002163508	0.043558201
egfr	CAPN2_1	chr1_223717830_G_A	0.0022465	0.020893773
egfr	TJP1_1	chr15_29718124_TA_T	0.002277416	0.026903818
egfr	ASPHD2_1	chr22_26442326_G_A	0.002296851	0.029916144
egfr	IFT43_1	chr14_76082206_T_G	0.002305612	0.012552105
egfr	CASK_1	chrX_41578463_T_G	0.002309184	0.043343775
egfr	C21orf33_1	chr21_44144829_C_T	0.002316139	0.047114252
egfr	AFAP1L2_1	chr10_114294856_CCTAA_C	0.00232372	0.037962739
egfr	MEI1_1	chr22_41699656_A_C	0.002354824	0.019192604
egfr	HAUS6_1	chr9_19080551_G_A	0.002357763	0.027262757
egfr	LRRC8E_1	chr19_7899842_G_A	0.002381607	0.011668019
egfr	SMARCB1_1	chr22_23787366_GGC_G	0.002396307	0.000127894
egfr	DUT_1	chr15_48332272_A_C	0.002405318	0.00018263
egfr	MON1A_1	chr3_49911902_A_G	0.002439566	0.010543368
egfr	SASH1_1	chr6_148440274_CT_C	0.002448515	0.046157021
egfr	MAP1S_1	chr19_17726640_A_C	0.002527497	0.022464441
egfr	TOE1_1	chr1_45340381_G_A	0.002528538	0.048016234
egfr	CNOT7_1	chr8_17242848_C_T	0.002530932	7.40E-11
egfr	CD244_1	chr1_160836124_G_A	0.002583957	0.026316972
egfr	EPM2AIP1_1	chr3_36992730_A_C	0.002610713	0.00113706
egfr	PRSS16_1	chr6_27249457_C_T	0.002649855	0.041003068
egfr	GPSM3_1	chr6_32192179_T_C	0.002655487	0.017253689
egfr	UGDH_1	chr4_39527132_G_A	0.002672816	0.035973223
egfr	AIG1_1	chr6_143060973_T_C	0.002697343	0.001184612
egfr	PMS1_1	chr2_189864380_G_A	0.002709035	0.028805775
egfr	PTGFR_1	chr1_78497752_G_A	0.002814073	0.008690688
egfr	AGPAT2_1	chr9_136674614_A_G	0.002858165	0.022967509
egfr	CBL_1	chr11_119278299_T_G	0.002995636	0.015544213
egfr	RAB37_1	chr17_74694690_G_A	0.003050869	0.017656336
egfr	GTPBP3_1	chr19_17338111_A_C	0.003059974	0.000709713
egfr	HDAC4_1	chr2_239053232_A_C	0.003067942	0.036469606
egfr	MBD3_1	chr19_1577118_C_T	0.003069952	0.001822739
egfr	CEP170_1	chr1_243164906_G_A	0.003157617	0.005533907
egfr	S100A16_1	chr1_153607964_A_G	0.003160582	0.026054854
egfr	DCK_1	chr4_71022615_CT_C	0.003222902	0.021365647
egfr	INF2_1	chr14_104713013_A_C	0.003224544	0.022440089
egfr	MYO6_1	chr6_75870526_T_C	0.003249199	0.022167818
egfr	CDS1_1	chr4_84635369_T_A	0.003299427	0.032630939
egfr	CTDSPL_1	chr3_37980672_C_T	0.003333659	0.043268165
egfr	EPB41L1_1	chr20_36187855_G_T	0.003410098	0.042407864
egfr	FGR_1	chr1_27617489_T_A	0.003443717	0.014581374
egfr	CAPRIN1_1	chr11_34051813_A_G	0.003553009	0.001206062
egfr	FOXC1_1	chr6_1612184_TA_T	0.00358795	0.004712911
egfr	ARHGEF6_1	chrX_136685627_G_A	0.003598733	0.001837929
egfr	BCAR3_1	chr1_93674923_G_C	0.003606528	0.049870881
egfr	BCL9L_1	chr11_118897861_A_C	0.003681075	0.034238861
egfr	TMEM201_1	chr1_9610425_T_A	0.003707837	0.025977963
egfr	RPS11_1	chr19_49496985_C_T	0.003720736	0.048243831
egfr	GMEB1_1	chr1_28690201_G_T	0.003734863	0.005247117
egfr	XRCC5_1	chr2_216109182_G_C	0.00380529	0.019360584
egfr	IL13RA1_1	chrX_118776541_G_T	0.003874528	0.009303333
egfr	PRR14_1	chr16_30651924_T_G	0.003882844	0.041861928
egfr	SH2B3_1	chr12_111418260_C_G	0.003991404	0.00753988
egfr	DTNBP1_1	chr6_15662698_A_G	0.00400197	0.006306033
egfr	PADI1_1	chr1_17228910_T_G	0.004006843	0.013302935
egfr	FAF1_1	chr1_50787989_A_G	0.004030148	0.030848308
egfr	RAB11FIP5_1	chr2_73075763_G_GGCCT	0.004085081	0.024778824
egfr	ZBTB40_1	chr1_22508509_T_G	0.004115308	0.00741291
egfr	BLCAP_1	chr20_37517746_T_C	0.004121218	0.011965638
egfr	KIF2A_1	chr5_62373627_T_G	0.004150384	0.036674489
egfr	HCFC1_1	chrX_153963207_T_G	0.004154957	0.001579155
egfr	HINFP_1	chr11_119121467_T_C	0.004250524	0.04539997
egfr	PRDM2_1	chr1_13823349_T_A	0.004303676	0.011003429
egfr	EIF4E_1	chr4_98902074_AT_A	0.004333629	0.008214508
egfr	PARVG_1	chr22_44206294_C_G	0.004424	0.028583204
egfr	COX18_1	chr4_73064835_G_A	0.004489575	0.009081073
egfr	WDR33_1	chr2_127701640_C_G	0.004497758	0.006721664
egfr	ARHGAP9_1	chr12_57474460_G_A	0.004523019	0.041357487
egfr	GGCX_1	chr2_85550432_A_G	0.004614743	0.015128917
egfr	ZNF182_1	chrX_47983350_T_G	0.004661316	0.045101518
egfr	ANXA6_1	chr5_151117292_C_T	0.004727288	0.038173193
egfr	RPL14_1	chr3_40457950_G_A	0.004955666	0.001218496
egfr	FCHO2_1	chr5_73082876_ATT_A	0.004962427	0.029256929
egfr	RAB28_1	chr4_13473790_TATC_T	0.004968595	0.040901005
egfr	RNGTT_1	chr6_88769645_C_T	0.00502562	0.002545266
egfr	NNT_1	chr5_43602611_T_C	0.005081886	0.030151517
egfr	CLDN1_1	chr3_190308594_C_T	0.005105908	0.019956392
egfr	NRN1_1	chr6_6003752_C_T	0.005133833	0.006175355
egfr	ZNF423_1	chr16_49635837_A_C	0.005155281	0.015077717
egfr	YES1_1	chr18_732727_A_G	0.00519113	0.026256279
egfr	RAPGEF6_1	chr5_131433731_GA_G	0.005213959	0.0053626
egfr	MGAT4B_1	chr5_179799918_A_G	0.005262946	0.044186289
egfr	GATAD2B_1	chr1_153818250_T_C	0.005279052	0.026743921
egfr	FCRL5_1	chr1_157518564_T_C	0.005397526	0.023539142
egfr	ACSS2_1	chr20_34925819_A_C	0.00560253	0.016776881
egfr	CTR9_1	chr11_10773884_CAAAAA_C	0.005625384	0.03664895
egfr	INPP5B_1	chr1_37872885_G_T	0.005738649	0.010365859
egfr	RPAIN_1	chr17_5421266_TTC_T	0.005740177	0.041469888
egfr	RCHY1_1	chr4_75509142_T_A	0.00575286	7.00E-06
egfr	RASSF7_1	chr11_562335_A_C	0.005935904	0.018138357
egfr	NKX3-2_1	chr4_13541263_A_G	0.00596504	0.000419444
egfr	IGFBP3_1	chr7_45917562_GT_G	0.006141827	0.045400401
egfr	LTBR_1	chr12_6385217_T_C	0.006192879	9.81E-05
egfr	GNG2_1	chr14_51950694_A_C	0.006226032	0.02637487
egfr	NAP1L1_1	chr12_76084896_T_C	0.006264126	0.018182577
egfr	GULP1_1	chr2_188589974_C_CT	0.006362476	0.004507263
egfr	PXDC1_1	chr6_3727577_C_G	0.006364895	0.027367829
egfr	WDR12_1	chr2_202897546_T_A	0.006402216	0.044170968
egfr	TMBIM6_1	chr12_49742405_G_A	0.006435087	0.019471463
egfr	PPM1D_1	chr17_60656452_CA_C	0.006580355	0.01692061
egfr	RPA2_1	chr1_27907061_GA_G	0.006586873	0.02798096
egfr	PRR3_1	chr6_30562126_T_G	0.006592704	0.005676599
egfr	RBM28_1	chr7_128310614_C_A	0.006924451	0.019795754
egfr	ENAH_1	chr1_225519569_GAAAA_G	0.007036997	0.048924277
egfr	KIAA0922_1	chr4_153592379_A_G	0.0070597	0.048688528
egfr	TRIM2_1	chr4_153276097_A_G	0.007183471	0.011894098
egfr	ATP8B1_1	chr18_57731374_T_C	0.007320467	0.035819404
egfr	QSOX1_1	chr1_180178802_A_G	0.007420273	0.008203943
egfr	MB_1	chr22_35607296_C_G	0.007592955	0.045421658
egfr	ORAI2_1	chr7_102433548_G_A	0.007786599	0.035889292
egfr	WNT7B_1	chr22_45931386_G_A	0.007831858	0.025701725
egfr	PIKFYVE_1	chr2_208330748_GT_G	0.007852983	0.009816454
egfr	ARHGAP32_1	chr11_128972609_T_G	0.007895267	0.007875634
egfr	SH3YL1_1	chr2_249571_C_T	0.007939764	0.043096755
egfr	DEPDC5_1	chr22_31843912_CT_C	0.00801665	0.025230811
egfr	VSIG10_1	chr12_118073908_T_G	0.008024404	0.001976122
egfr	SLX4_1	chr16_3595722_A_C	0.008031231	0.013087513
egfr	REEP3_1	chr10_63621980_A_G	0.008035335	0.03021965
egfr	FARSB_1	chr2_222571709_T_C	0.00812224	0.037339824
egfr	NDUFS3_1	chr11_47578800_A_G	0.00843631	0.008511324
egfr	HIBADH_1	chr7_27538786_G_A	0.008437431	0.025866827
egfr	SCLT1_1	chr4_128957191_A_C	0.008485976	0.015508556
egfr	SLC20A2_1	chr8_42439475_C_T	0.008560526	0.001296999
egfr	LMO7_1	chr13_75855483_C_A	0.008616687	0.000790188
egfr	SREBF2_1	chr22_41897136_G_C	0.008665061	0.031235978
egfr	SPAG1_1	chr8_100194395_C_A	0.008766072	0.025833604
egfr	NCAM1_1	chr11_113270137_A_G	0.008796809	0.040540565
egfr	ATP1B1_1	chr1_169111407_C_G	0.008822814	0.015890801
egfr	PLXNB2_1	chr22_50281752_C_G	0.008850507	0.048268974
egfr	PFAS_1	chr17_8269414_A_G	0.008856682	0.026137416
egfr	CEP152_1	chr15_48762574_G_C	0.008866418	0.044026406
egfr	GNRH1_1	chr8_25423267_A_G	0.009056061	0.039449902
egfr	CARD10_1	chr22_37508612_T_C	0.009110799	0.021324272
egfr	COL6A3_1	chr2_237351090_T_G	0.00914922	0.009459532
egfr	RBM12B_1	chr8_93733158_G_T	0.009183374	0.012443278
egfr	ITPKC_1	chr19_40737666_A_C	0.009205546	0.045257656
egfr	ARHGAP31_1	chr3_119390922_C_T	0.009221747	0.042725387
egfr	GRAMD1A_1	chr19_35022992_C_T	0.00930255	0.030347265
egfr	SAE1_1	chr19_47131056_T_G	0.009443122	0.006083296
egfr	MICALL1_1	chr22_37924607_T_G	0.009460572	0.025017274
egfr	GABRB2_1	chr5_161336809_G_A	0.009484795	0.019276169
egfr	SPINT2_1	chr19_38287977_A_G	0.009500965	0.018521267
egfr	ATXN7_1	chr3_63990247_A_C	0.009623217	5.97E-05
egfr	TATDN2_1	chr3_10248824_C_CT	0.009659313	0.000116552
egfr	AP4E1_1	chr15_50968319_T_G	0.009752147	0.046599506
egfr	CHST2_1	chr3_143121243_A_G	0.009892538	0.040099833
egfr	PRKAG2_1	chr7_151560579_A_G	0.009896448	0.024618763
egfr	C16orf45_1	chr16_15596596_T_G	0.009927037	0.04351851
egfr	SULT2B1_1	chr19_48591514_T_G	0.009943382	0.006727275
egfr	DSTN_1	chr20_17600864_A_G	0.009947784	0.000427203
egfr	TPD52L2_1	chr20_63889961_A_C	0.010191021	0.005896198
egfr	E2F2_1	chr1_23521217_C_G	0.010495212	0.008957912
egfr	TSEN34_1	chr19_54192354_T_G	0.010854598	0.001848481
egfr	FOXN3_1	chr14_89162512_A_C	0.011014558	0.001249668
egfr	MND1_1	chr4_153408912_G_GTATATA	0.011263008	0.006400349
egfr	ZDHHC5_1	chr11_57696028_T_C	0.01129582	0.000204877
egfr	ARMCX4_1	chrX_101488321_C_G	0.011422104	0.008157752
egfr	P2RY11_1	chr19_10115376_G_A	0.011466091	0.000105991
egfr	C1orf198_1	chr1_230839028_T_C	0.011890625	0.008759206
egfr	TPTE2_1	chr13_19425773_G_A	0.011929579	0.00812417
egfr	TMEM206_1	chr1_212379769_G_C	0.01195192	0.000739419
egfr	REEP5_1	chr5_112891583_T_A	0.012573055	0.001996089
egfr	CNNM4_1	chr2_96798981_T_G	0.012933399	0.000393837
egfr	GPR65_1	chr14_88011069_C_T	0.013002947	0.005376071
egfr	ZDHHC7_1	chr16_84981848_T_G	0.013133304	0.007398316
egfr	KCNAB3_1	chr17_7925552_G_A	0.013376003	0.008474756
egfr	ASNSD1_1	chr2_189670812_C_T	0.013663903	0.004106264
egfr	LY9_1	chr1_160814485_A_C	0.014209114	0.004017681
egfr	SKIV2L2_1	chr5_55307994_T_C	0.01489715	0.008290134
egfr	MADD_1	chr11_47325027_T_C	0.01504914	0.001497343
egfr	ITPRIPL1_1	chr2_96325641_T_G	0.0151793	0.004828474
egfr	SDC4_1	chr20_45330303_T_G	0.015973482	0.000496261
egfr	SLC2A8_1	chr9_127398490_G_A	0.016168742	0.003968261
egfr	CSF2RB_1	chr22_36923285_A_C	0.016450302	0.008060727
egfr	WWTR1_1	chr3_149669685_C_T	0.016674011	0.040303211
egfr	PEX10_1	chr1_2410431_A_C	0.017756279	7.19E-05
egfr	SCMH1_1	chr1_41033845_T_G	0.01786284	0.006455807
egfr	WNT10A_1	chr2_218882471_A_C	0.018148757	0.008633339
egfr	SIRT4_1	chr12_120303510_G_GAA	0.018478224	0.002426212
egfr	SLC25A43_1	chrX_119451980_A_G	0.018546868	0.000927303
egfr	SLC35F5_1	chr2_113723196_TA_T	0.019332514	0.009792442
egfr	PLEKHA5_1	chr12_19369550_A_AAAAG	0.019740309	0.004535622
egfr	RASEF_1	chr9_82982805_CAGAG_C	0.019798987	5.81E-06
egfr	RASSF2_1	chr20_4797919_T_G	0.019937429	0.007153311
egfr	ANKRD44_1	chr2_197099965_G_A	0.020081182	0.009634061
egfr	ZFYVE19_1	chr15_40812591_A_AAG	0.020142634	0.000177529
egfr	TMEM2_1	chr9_71704688_T_G	0.02064031	0.00528138
egfr	TMEM159_1	chr16_21174063_G_A	0.020994925	0.001734513
egfr	PEX13_1	chr2_61045783_A_T	0.021004523	0.005293964
egfr	BCAR1_1	chr16_75229126_T_A	0.021029307	0.004775721
egfr	SLC25A38_1	chr3_39389590_G_A	0.021402491	5.21E-05
egfr	ING5_1	chr2_241711916_A_C	0.021779734	0.000297693
egfr	AHR_1	chr7_17339074_A_C	0.021825994	0.009928124
egfr	ETV1_1	chr7_13900838_A_C	0.022234699	0.00028392
egfr	FUS_1	chr16_31191353_T_G	0.022580325	0.000527105
egfr	ELMO1_1	chr7_36986095_A_C	0.022675843	0.000582138
egfr	FLI1_1	chr11_128772826_T_G	0.022696029	2.10E-08
egfr	RBPJ_1	chr4_26321137_C_A	0.023026755	0.005948758
egfr	TGM1_1	chr14_24260894_A_C	0.023877255	4.06E-05
egfr	MAD2L2_1	chr1_11680485_C_A	0.024343193	0.005401081
egfr	CCDC66_1	chr3_56613771_T_C	0.024734355	0.00694013
egfr	E2F3_1	chr6_20402547_A_C	0.024779926	0.001096854
egfr	TRIM47_1	chr17_75875198_A_C	0.025043777	0.006990418
egfr	LACTB2_1	chr8_70657773_A_C	0.025193805	0.000265188
egfr	S100A13_1	chr1_153619154_A_C	0.026872567	0.000285894
egfr	PRKCZ_1	chr1_2059508_T_G	0.027355157	0.000553783
egfr	KIAA0430_1	chr16_15601202_A_G	0.027767771	0.008344755
egfr	PARP1_1	chr1_226377365_T_C	0.028078591	0.000660394
egfr	VMP1_1	chr17_59841357_A_C	0.028144116	0.00700708
egfr	TRPM7_1	chr15_50619668_AT_A	0.028234282	0.007696192
egfr	RPL11_1	chr1_23695353_C_A	0.028842665	0.006999268
egfr	RHPN2_1	chr19_33002924_G_A	0.02894401	0.001694408
egfr	MAST3_1	chr19_18107675_A_T	0.028979003	0.002887665
egfr	SACS_1	chr13_23354711_A_C	0.029483838	0.007436264
egfr	ZBTB4_1	chr17_7463332_C_G	0.030579241	0.009123992
egfr	SSH3_1	chr11_67309455_A_C	0.031167208	0.006068708
egfr	STAU1_1	chr20_49153934_T_C	0.031695969	0.047157357
egfr	PRSS22_1	chr16_2853046_G_C	0.032478102	0.003660773
egfr	SRRD_1	chr22_26488073_G_A	0.03313164	0.001986837
egfr	ITGB8_1	chr7_20399120_C_G	0.033295835	0.000193939
egfr	FLII_1	chr17_18245630_C_G	0.033989678	0.00994433
egfr	TMEM40_1	chr3_12769284_C_T	0.034416268	0.003842868
egfr	SLC19A1_1	chr21_45512453_A_C	0.034642487	0.009916208
egfr	FBN1_1	chr15_48425289_G_T	0.035154355	0.007224526
egfr	TMC4_1	chr19_54160564_G_A	0.03557474	0.008695606
egfr	TACC2_1	chr10_122132454_G_A	0.036645036	7.09E-05
egfr	HEATR5A_1	chr14_31315848_T_C	0.037815962	0.000583004
egfr	SLC25A24_1	chr1_108161212_C_T	0.038139179	0.001625377
egfr	TMEM39B_1	chr1_32091713_A_C	0.038513492	0.008701631
egfr	ANKRD22_1	chr10_88831974_A_C	0.039475145	0.00796284
egfr	SFSWAP_1	chr12_131753058_C_G	0.039748632	0.004289964
egfr	C1orf54_1	chr1_150279750_G_C	0.039956255	0.001281485
egfr	SEPT10_1	chr2_109564377_G_T	0.040053757	0.00487648
egfr	FOS_1	chr14_75280999_A_C	0.04011469	0.001488063
egfr	AARS2_1	chr6_44301927_CAGG_C	0.041166243	0.004966986
egfr	EMP1_1	chr12_13211531_T_G	0.041461108	0.001600571
egfr	FBXO2_1	chr1_11648995_C_G	0.042445462	0.005932397
egfr	UBE3A_1	chr15_25408653_C_A	0.044428109	0.002080316
egfr	GPC1_1	chr2_240451007_T_G	0.044965723	0.007919222
egfr	ACTN4_1	chr19_38728028_T_G	0.045229843	0.005408687
egfr	EPB41L4B_1	chr9_109182980_T_C	0.045378555	0.002429073
egfr	SERTAD3_1	chr19_40441466_GGATC_G	0.045415799	0.001465832
egfr	WHSC1L1_1	chr8_38315857_G_C	0.046096872	0.004506209
egfr	QRICH1_1	chr3_49076524_TAAA_T	0.046339149	0.007356338
egfr	CAMSAP3_1	chr19_7618018_A_C	0.046801001	0.000416732
egfr	TCHP_1	chr12_109907472_T_G	0.047094137	0.003720466
egfr	TUFT1_1	chr1_151565936_G_A	0.048675231	0.004559558
egfr	CHMP1A_1	chr16_89649256_C_T	0.048695701	0.003804631
egfr	LAMB2_1	chr3_49125146_T_G	0.049754671	0.002569959
egfr	PNRC2_1	chr1_23961290_GCTT_G	0.049756672	0.006024417
egfr	MARVELD2_1	chr5_69419733_A_C	0.049786079	0.007668831
egfr	SLC22A18_3	chr11_2919250_T_G,chr11_2903361_G_A,chr11_2919268_T_G	0.00010006113410040524,0.0011537278855378685,0.03948380156101269	0.003253241739951185,0.009485355002003664,0.004588734004408302
egfr	SH3D19_3	chr4_151148254_TACACACACACACACAC_T,chr4_151122202_T_C,chr4_151148202_G_T	0.00010065962678441032,0.015768562077467373,0.0009087951468125592	0.016052772944150497,0.00026537095134489047,0.004030165987762314
egfr	LARS2_5	chr3_45474156_T_C,chr3_45476267_G_A,chr3_45488909_G_A,chr3_45500591_T_C,chr3_45417241_A_G	0.00010374784857743111,3.7424426310272928e-06,1.2434210249182578e-07,6.432927229497336e-08,0.004689576487598519	1.1453239774161183e-13,9.671821420877082e-13,6.257680298053254e-14,4.345853387032865e-14,0.022164736928693304
egfr	SRGAP1_2	chr12_64142411_T_C,chr12_64097222_GTT_G	0.00010959539878441124,0.0011886231256692465	0.006505852651723906,0.02613509690642953
egfr	ALDH3A1_3	chr17_19742310_G_A,chr17_19748298_C_T,chr17_19740913_C_G	0.00011241479007533596,0.0023838380538555946,0.026511359318080838	0.016065461057378518,0.04852415829065191,0.0007153928676742558
egfr	LPIN3_5	chr20_41345676_A_G,chr20_41358461_T_G,chr20_41358465_C_G,chr20_41340873_C_A,chr20_41350009_T_G	0.00011710984250539265,0.000846270947552816,0.0063262440202536815,7.192100726008128e-05,0.033798727519866234	0.001902884670314011,5.712471333190794e-05,6.891802498643105e-05,0.025739865299148755,0.0036707505113827256
egfr	LAMB3_3	chr1_209626885_C_T,chr1_209626996_C_T,chr1_209630438_C_T	0.00012286163323842149,0.0001560650413956853,0.00010264198687506551	0.014463355479842403,0.005725629984184445,0.0254414675884508
egfr	RAC1_2	chr7_6398689_A_C,chr7_6401802_T_G	0.00012312607987750062,0.022378677686989437	0.0005959472772163739,0.003141262984465143
egfr	CERKL_2	chr2_181603835_A_C,chr2_181678048_T_G	0.00012332912254087272,0.00048702996607960313	8.976196985876391e-05,0.010552400468127526
egfr	MTO1_2	chr6_73492090_C_T,chr6_73473277_C_CAGAT	0.0001242869571724915,0.027975699490295474	0.0009500421967262693,0.0034299441619718607
egfr	SUMF1_2	chr3_4419885_G_A,chr3_3846683_A_C	0.00013129129316308624,0.007888292383663753	0.017506933739797337,0.0026519652256760252
egfr	WDFY4_5	chr10_48946696_T_C,chr10_48774557_A_C,chr10_48823427_C_T,chr10_48826590_T_A,chr10_48709976_C_T	0.00014298234740370438,7.877438075749654e-06,0.006750199117687904,0.008731995024502738,0.0057882693531272345	0.03553981554074815,0.02592605078891659,0.041159506689191376,0.03934434383747865,0.036092320181802036
egfr	DSC2_3	chr18_31091249_T_G,chr18_31093490_T_G,chr18_31080273_C_T	0.00014328639925920681,0.026176748525728964,0.004444668756137834	0.002053875263128439,3.7895626071773765e-05,1.9855794171946574e-05
egfr	MBD1_4	chr18_50276088_C_A,chr18_50276601_A_G,chr18_50275492_T_G,chr18_50275430_G_A	0.00014793743904567252,0.01877342572270696,0.003092273916220477,0.0033406482616730533	0.002775832151787685,0.0007205116796968372,0.027183042271681262,0.047488972926164726
egfr	KIAA1671_2	chr22_25029373_T_C,chr22_25170874_A_C	0.00015698694769979702,0.0006020288880688977	0.04147687852552058,0.03878706897291035
egfr	MET_3	chr7_116740945_T_G,chr7_116757685_T_G,chr7_116740947_C_G	0.00016797515698396606,0.002832945772163542,0.002231117554658809	0.00017295700570667475,5.0554093231126755e-05,0.0012218666498089645
egfr	RCBTB1_2	chr13_49585356_T_A,chr13_49533768_G_A	0.0001756869709333519,0.009455073314037034	0.02533885676009956,0.019692263494698818
egfr	PPL_4	chr16_4883459_A_G,chr16_4894423_G_C,chr16_4901058_T_G,chr16_4891747_T_G	0.0001758787943382569,0.0007098905861696843,0.0005647077594982514,0.011689794335935037	0.009286392985327631,0.04550405331166151,0.01682150071796396,0.0032410422551606864
egfr	TMEM63A_3	chr1_225856800_GC_G,chr1_225856891_C_T,chr1_225845173_C_T	0.00017631469170194104,0.0005047149993335916,1.5371108451049484e-05	0.04262290781357216,0.031894233309554584,0.039853481810337744
egfr	KDM4B_5	chr19_5110783_A_G,chr19_5047680_G_A,chr19_5111856_C_T,chr19_5152376_T_C,chr19_5114105_T_G	0.00018149502531503815,0.0011449297013059851,3.0255655048228253e-05,0.0056532335440754155,0.005029743152006167	0.0038743952075057523,0.0010649511420676163,0.008640482718151363,0.012419815562589162,0.0315424322762135
egfr	TAF4B_2	chr18_26286027_C_A,chr18_26293570_AT_A	0.0001933876544072626,0.0006065453361074753	0.005234163638807017,0.02416136973363145
egfr	MAP2K7_3	chr19_7905750_A_G,chr19_7911231_T_C,chr19_7910579_A_C	0.00020437876506728577,5.172101478935253e-05,6.985639899444967e-05	0.026466975715454883,0.014436739312155004,0.014559538606612087
egfr	EGFR_5	chr7_55160480_C_T,chr7_55170771_T_G,chr7_55205133_G_A,chr7_55181370_G_A,chr7_55205662_A_C	0.00020841604787297526,0.00045465182013688124,0.02209047666362801,0.00015707737069901731,0.0019734565993096485	0.042584839287283,0.004588325394927623,0.003745674667154008,0.030349772078527886,0.0007797573368817686
egfr	MED4_2	chr13_48079728_CAAA_C,chr13_48077399_A_AT	0.00021592440051490123,0.00970359638804136	0.028274397927711425,0.04285821577494423
egfr	PSMG1_2	chr21_39183425_G_C,chr21_39175728_T_C	0.00022608775731841645,0.012584465994979182	0.00513068025831651,0.006708397725563725
egfr	SYMPK_3	chr19_45823908_G_A,chr19_45835234_G_A,chr19_45842628_T_C	0.0002277738548719044,7.560389488032653e-05,0.007665716537369837	0.03948007686982654,0.026714512477614062,0.0420060391850977
egfr	CNKSR1_6	chr1_26180299_A_G,chr1_26181802_G_A,chr1_26181989_T_C,chr1_26183270_A_C,chr1_26184255_A_C,chr1_26180691_T_G	0.00022855371657961118,0.000553633072814145,0.004976293349453925,0.0012311577321858017,0.00011380023959208459,2.366839986118124e-05	0.0031268776228605263,0.042309660108738684,0.031585176815995236,0.007340521806393782,0.03620130672603948,0.0014019419704167026
egfr	LGR4_3	chr11_27373900_C_T,chr11_27380156_G_A,chr11_27368981_G_A	0.00022889582425503487,0.00022889582425503487,7.68908468665983e-05	0.02925705779271898,0.02925705779271898,0.007261247877037425
egfr	VTCN1_3	chr1_117157003_C_T,chr1_117172345_T_C,chr1_117172578_ATTT_A	0.0002510217205927707,8.944919469827468e-06,0.016016251707355836	0.03055768777478911,0.023227355162109414,0.001594504991034824
egfr	CRBN_6	chr3_3151010_G_T,chr3_3152273_A_C,chr3_3154589_AT_A,chr3_3175444_AT_A,chr3_3179746_C_T,chr3_3150840_A_ATAAC	0.0002626503373527541,0.013274951670738794,7.062286693324899e-05,0.0004048382754165016,0.003012811333138018,3.124023410218089e-05	0.0018118056645904023,0.00018124433406194467,2.1732312542326866e-07,7.214198132928058e-05,1.1224125713318842e-06,3.115850854605648e-06
egfr	SMCHD1_5	chr18_2707621_G_A,chr18_2724932_A_T,chr18_2763699_C_T,chr18_2656105_T_G,chr18_2795854_A_G	0.00026503656166190905,0.009320150621080624,0.0042306245640629115,0.025865035105419227,0.0001080554536414254	7.290016375189198e-05,0.03677531412547839,0.02250972081801197,3.289863234127764e-05,0.037011899642268684
egfr	HDAC11_2	chr3_13496579_C_G,chr3_13496863_T_TG	0.00027757125208069643,0.00015267586088891374	0.0271728892750038,0.0149184097594151
egfr	PIK3CD_4	chr1_9720778_T_G,chr1_9721354_C_G,chr1_9722498_C_T,chr1_9710297_C_T	0.00030314689537509136,7.877458405180158e-05,2.4181398805762395e-05,0.002966501395718009	0.0012148539768169404,0.04037203630033394,0.011926248274336807,0.011351289482054416
egfr	GCDH_3	chr19_12891586_G_C,chr19_12891749_T_G,chr19_12899706_A_G	0.000306793254674835,0.0003686903209515677,0.009343822168831345	0.0326186066813529,0.03376530749875928,0.00026130883839357806
egfr	SEC11C_2	chr18_59152698_T_C,chr18_59158845_T_C	0.00030911539588566946,0.00956493460787828	0.0022574597582570113,0.029955010760308976
egfr	SAFB_2	chr19_5667193_AC_A,chr19_5668433_GT_G	0.0003098805881779707,0.044739771014985504	0.002063538258127222,0.0026106809691974946
egfr	ATP6V1B2_3	chr8_20212278_G_C,chr8_20218183_C_A,chr8_20214681_A_G	0.0003172005709671975,1.980177091110716e-06,7.277973285376886e-05	0.001539493748390498,0.02168738622123026,0.025450124159694176
egfr	PUS3_4	chr11_125896149_C_A,chr11_125896278_A_C,chr11_125896309_G_C,chr11_125896312_C_T	0.00031902172789162014,0.0016768215144890312,0.00019026344698916655,0.0006367828673033801	0.02249427642441209,0.03343255062895107,0.0192679955094738,0.02546202950317841
egfr	XDH_2	chr2_31383804_G_A,chr2_31398732_T_C	0.00033628525023115955,0.007506095065621764	0.04221528923752448,0.006330815240399064
egfr	WDR7_4	chr18_56679573_T_G,chr18_56781547_G_A,chr18_56815915_A_G,chr18_57027330_A_ACGGC	0.00034150498667130327,3.859660027634848e-06,0.002362739963128272,0.006245785108127786	1.7583606026050092e-08,0.0071713352600959014,0.003286339206119661,0.04783850584421885
egfr	GJB2_2	chr13_20189503_C_T,chr13_20189241_T_C	0.00035796332888395017,0.008815817126700895	0.005240901157790961,0.03930064243744275
egfr	NFATC1_5	chr18_79486406_T_G,chr18_79486978_G_A,chr18_79449015_A_G,chr18_79451175_T_C,chr18_79467476_A_G	0.0003603073768446487,5.049273733042917e-05,0.02785434119032008,0.02220634088861789,0.0002507020345223831	0.018612271205492262,0.026732897678207176,0.0006549922975230749,0.0005874163668026321,0.003817175702412812
egfr	TMEM141_2	chr9_136791905_T_C,chr9_136791680_A_G	0.0004169452454367874,3.984588209897019e-05	0.03333885281311693,0.020229651998436324
egfr	GON4L_3	chr1_155750010_A_G,chr1_155813972_C_T,chr1_155826993_A_G	0.0004229050700030183,0.009903573910672052,0.002653632924091959	0.014960076537640884,0.0034455240142541605,0.03840390796922083
egfr	THOC1_4	chr18_218753_C_A,chr18_259800_G_GA,chr18_264012_G_A,chr18_260303_A_C	0.00043864187590166915,3.026788938964173e-05,6.794818264684467e-06,0.0036079810571773866	0.01174777561883113,0.04550027828580569,0.038030003830584136,0.031572528408919984
egfr	MOCOS_3	chr18_36268700_A_ATACAT,chr18_36195408_G_A,chr18_36195416_C_T	0.00045986586717034416,0.0014799368107284092,0.001731239408871138	3.5975000177046293e-13,0.007257645332317387,0.011340791435594116
egfr	TBC1D1_2	chr4_37920795_A_T,chr4_38102880_CA_C	0.000488440493483436,0.0003703609091265926	0.005935046245136817,0.0040311926239692975
egfr	MYOF_6	chr10_93402739_A_T,chr10_93335910_A_G,chr10_93341723_C_T,chr10_93349980_G_A,chr10_93456833_C_T,chr10_93379679_T_C	0.0005166123667663002,0.008644559399569549,0.030314897647199957,0.007378711399757192,0.014254715712501044,0.03684609798869681	0.008275987890594253,0.013383779511641422,1.0154009952651607e-05,0.013694532403103154,4.5730649026336375e-05,0.0006543495060757152
egfr	RBBP5_4	chr1_205096605_G_T,chr1_205105296_C_T,chr1_205121757_C_G,chr1_205101436_A_G	0.0005227440198400762,0.00526416157273805,0.0030657012636972646,0.0013099169827028106	0.015139833707904771,0.008644227461685475,0.012113677398994695,0.04046396583686459
egfr	CLASP2_2	chr3_33577059_G_GA,chr3_33684322_GA_G	0.0005299045117610777,0.035952102365944434	0.0005875510468728085,0.0001503619637647613
egfr	PHACTR1_2	chr6_13206050_C_T,chr6_12749854_G_C	0.0005337924756049767,0.004317442990912475	0.00039532970764163586,0.035334891294853864
egfr	ANAPC4_3	chr4_25396670_G_C,chr4_25396674_T_G,chr4_25405734_A_G	0.0005663311621920986,0.0013075373037905336,0.0465779350486673	0.000361328058170187,0.03220079967613157,0.0019550422066677508
egfr	PSMD5_2	chr9_120820914_A_G,chr9_120824459_T_G	0.0005809565738534683,0.0007453253514985393	0.02520354146772891,0.030923039758435706
egfr	ABCC3_4	chr17_50677651_A_G,chr17_50687493_T_G,chr17_50677654_A_G,chr17_50661130_G_A	0.0006252991041556168,0.01577297864138986,0.003896335000953405,0.0010188260367160796	0.031817085633522264,0.0088751921752167,0.04421726142800319,0.010430910480796323
egfr	PDS5A_8	chr4_39826222_A_G,chr4_39908552_GA_G,chr4_39920322_A_G,chr4_39928282_TCA_T,chr4_39874433_GT_G,chr4_39902522_ATT_A,chr4_39922752_TAA_T,chr4_39849438_CAA_C	0.0006804734038066716,0.0008478404674630213,0.0026866381085943365,0.00132808107004332,0.004772686052629922,0.0001500621143076567,0.007431666608049384,0.000683239660165417	0.013430761436295064,0.011566738826207195,0.012551712088653194,0.04498488242774648,0.0069892257136405615,0.002775620894064112,0.00845393532716467,0.015679705858385958
egfr	ARID1B_3	chr6_157084627_G_A,chr6_157084796_G_A,chr6_156779262_G_GCGC	0.0006899056725067633,0.00012305812201489173,0.003772804433314189	0.002480449952777213,0.003319459056638543,0.0297382920893214
egfr	ATP6V1D_2	chr14_67347484_T_C,chr14_67347517_C_T	0.0006971003770886628,0.004311412775348075	0.0458931703260112,0.04673425843690365
egfr	TSPAN15_2	chr10_69506088_T_G,chr10_69506076_T_C	0.0007322830521084773,0.005306461981362982	0.002401654647845401,0.00014212528801531312
egfr	MLH1_3	chr3_37007142_A_G,chr3_37012077_A_G,chr3_37042249_A_G	0.000740971042730754,0.00173625605182141,0.0001471514352872128	0.0011032555560560838,0.0188504234858543,0.00278116952700519
egfr	MCPH1_10	chr8_6563013_A_G,chr8_6414878_G_T,chr8_6415022_A_C,chr8_6442011_A_G,chr8_6444662_G_C,chr8_6621439_C_G,chr8_6621761_G_T,chr8_6643023_C_T,chr8_6643230_C_G,chr8_6445504_G_A	0.0007930301578494862,0.00783515709942311,0.0010653421345075958,0.01109994940299345,0.01748605668447073,0.014338437252537204,0.004071842491061435,0.0006919647053001271,0.012376440045340064,4.6837103256950894e-05	0.013491192511465546,0.00030214631498362885,1.4308699249286362e-06,0.000801511853950485,0.0006599247173344139,0.00022140087416861568,6.162352636469756e-05,4.2830362262517274e-05,0.0016916243554951818,0.00023822828634849838
egfr	APLP2_2	chr11_130110790_G_A,chr11_130141602_T_C	0.0008186783504663072,0.005144250183511083	0.0021295365540794004,0.003817157441436617
egfr	GDF11_2	chr12_55743444_T_G,chr12_55743453_A_G	0.0008261007388543191,0.03983988128537546	0.0038399667498981156,0.009308695658692865
egfr	DHRS1_2	chr14_24296416_G_A,chr14_24296478_G_A	0.0008309168215997886,0.0004203355659529219	0.0011625249597744401,0.0009759887418146756
egfr	HMBOX1_2	chr8_29019076_C_G,chr8_29049138_T_G	0.0008669919525569822,0.03171806222754735	0.004301459569275475,0.002544858829830765
egfr	FAM129B_3	chr9_127525147_A_C,chr9_127531490_GA_G,chr9_127578821_C_G	0.0008771327036108232,0.0021288478614580747,0.0022519852618096852	0.020053464930431048,0.031013612085774283,0.0009666899162254512
egfr	SQRDL_3	chr15_45676245_C_G,chr15_45659211_A_T,chr15_45659215_T_A	0.0008907771597097484,0.0020094614120517293,0.009204846533756823	0.014234174047984662,0.023564046281648054,0.01334902621156353
egfr	PAWR_3	chr12_79621127_A_T,chr12_79621127_A_C,chr12_79690012_G_C	0.0008953392161992621,4.018282599405261e-05,0.00946824676498348	0.00916697548400727,0.004195646894367022,0.04023621560178265
egfr	ZMYM4_2	chr1_35386039_A_G,chr1_35398970_A_G	0.0009255268514009688,0.0010268025209398274	0.047414902378186935,0.03220211892803819
egfr	PNISR_3	chr6_99400577_G_T,chr6_99400380_A_T,chr6_99400680_T_C	0.0009649647745143484,0.0007159697124499053,0.04773876660712681	0.00024058514444646938,0.04850971607266792,4.045878429706501e-05
egfr	KCTD1_2	chr18_26455686_TTTTG_T,chr18_26455824_G_A	0.0009651254517760071,0.00044897282981570764	0.011878660133524677,0.022677959399150814
egfr	YEATS4_4	chr12_69360050_G_A,chr12_69360067_T_C,chr12_69365771_AT_A,chr12_69359732_G_C	0.0009657838134951767,0.010865427433622845,0.00010196861904854136,0.004781622790417561	0.00020734016607029562,9.576513142549652e-05,0.005769237544482665,0.00015854860163792644
egfr	MYH14_4	chr19_50257459_C_G,chr19_50268152_A_C,chr19_50223372_A_C,chr19_50210705_A_C	0.0009907478792200786,0.00031027234534027856,0.009603188672713292,8.610623849100771e-05	0.003155642857162157,0.02679430539669753,0.04503905394492344,0.01011266806040028
egfr	TNRC6B_3	chr22_40246081_G_A,chr22_40322746_C_G,chr22_40270313_CTT_C	0.0010055560691593062,0.007906209412661305,0.009164202590452458	0.0005779404176446281,0.0047436478866502065,0.0364705418337816
egfr	INTS9_7	chr8_28780706_C_T,chr8_28787754_C_T,chr8_28793781_A_C,chr8_28793783_A_C,chr8_28835266_C_T,chr8_28775581_A_C,chr8_28775811_A_C	0.0010081741289715016,0.004592362992120706,0.0005120698884621372,0.0002773767656391789,0.02714848429874154,0.00020236348372473448,2.4854306942254155e-05	3.2138156864211546e-07,5.188443093736729e-09,4.024976616918393e-06,2.0930318384840388e-05,1.818850464108077e-06,3.257318543578891e-07,0.018623738854211223
egfr	SLC9A2_2	chr2_102708404_T_C,chr2_102683152_T_C	0.0010228970665369316,0.0005020081620733607	0.009615984790689362,0.009480536166577638
egfr	CABYR_2	chr18_24159761_T_C,chr18_24143046_A_T	0.0010567833091170056,0.0014968601112293539	0.005047158957377522,0.04396847891686953
egfr	GTF3A_3	chr13_27435783_G_C,chr13_27434894_G_C,chr13_27424632_T_C	0.0011190222584791265,0.004681955550098893,0.007918207229892667	6.8305505569380366e-06,4.651074413645253e-05,0.009084963551764854
egfr	C17orf80_2	chr17_73243051_A_T,chr17_73243095_T_G	0.0011654886198261731,0.004494422448579687	0.010085515976883222,0.004743723689710052
egfr	SMU1_3	chr9_33042147_G_GC,chr9_33048282_A_C,chr9_33062151_T_C	0.0011669696398791268,7.696816352170192e-06,0.01499894245869885	0.04706645923394905,0.031220105263435657,0.0036210535474734524
egfr	APP_3	chr21_25881669_T_G,chr21_25982373_C_A,chr21_26053118_T_G	0.0011674640267523098,9.245713138747127e-05,0.004308340981093568	0.0009005203285702301,0.013334900192842466,0.04036723851049838
egfr	SF3A2_2	chr19_2247907_A_C,chr19_2248684_C_T	0.0012266864812599976,0.002990131415570729	0.0030981828107111728,0.0468855780292127
egfr	MCM3AP_14	chr21_46242985_CA_C,chr21_46245202_GAAGA_G,chr21_46254361_G_A,chr21_46256797_G_A,chr21_46257020_T_C,chr21_46258860_A_G,chr21_46261213_T_C,chr21_46265873_T_C,chr21_46266025_A_G,chr21_46266238_C_T,chr21_46266260_T_C,chr21_46272884_C_T,chr21_46275481_C_G,chr21_46285323_T_C	0.0012527393891514607,0.00036535930217642055,0.0024609384326425487,0.04643229751040803,2.118510728826028e-05,2.887414182548247e-06,1.05276826358399e-07,0.00025970635193207507,0.0005620952054741439,5.716570824504117e-07,2.4174995461629513e-07,0.005818667124032619,0.0467983305638919,8.653902898907501e-05	0.0002736694696369044,1.7616074069549246e-05,1.3003369428929314e-06,2.3123117180340123e-05,2.0562643179742515e-06,8.354163607590267e-05,0.00029806921327546384,5.3648509797744586e-06,1.5227506753175702e-05,7.251148442399709e-05,0.00010743801329645878,1.1615547532865214e-07,1.858126949270524e-05,3.8129306546053804e-06
egfr	CLIP4_2	chr2_29160508_G_A,chr2_29167435_A_G	0.001256177781998004,0.0032393618837062445	0.004054702946614456,0.02363327883448803
egfr	TSC22D1_3	chr13_44574373_G_T,chr13_44574380_T_G,chr13_44573675_A_G	0.001377124084836583,0.015722049040498624,0.02470162730235456	0.0064804726533923464,0.0020304861527569297,5.907708401459935e-06
egfr	PKP3_3	chr11_403980_G_A,chr11_404317_C_T,chr11_397331_G_C	0.0013876622699982295,0.016481995505848203,3.1228708373215485e-07	0.018674886861837936,0.009799627021991927,0.04880244320980319
egfr	CASP8AP2_4	chr6_89867828_C_A,chr6_89846678_CT_C,chr6_89854793_T_G,chr6_89867387_T_G	0.0013957399418989352,0.0012351347166879073,0.01485793169450881,0.029929799896047743	0.004638447540709211,0.00012650141154496166,0.0049509957510286366,0.007919221858804896
egfr	SUGP1_3	chr19_19297181_T_G,chr19_19320614_T_G,chr19_19321154_G_T	0.001497727430536191,0.0019392453885837852,1.1604792778575085e-06	0.004713359874536658,0.0005015062282813169,2.8690586178505662e-05
egfr	MTMR14_2	chr3_9701714_TGGAG_T,chr3_9688859_C_T	0.0015228522402605245,0.0034777774244127892	0.0064175485415249155,0.007328897092709648
egfr	RIOK2_2	chr5_97167674_T_C,chr5_97179013_C_G	0.0015264299232640686,0.0009434563320843556	0.018107759921786072,0.01839083931192911
egfr	HCLS1_5	chr3_121631746_C_A,chr3_121642799_G_A,chr3_121642940_G_A,chr3_121647276_C_T,chr3_121647530_A_G	0.001531370286315401,0.007140010061027548,0.0056491920403494,0.0056491920403494,0.0033035345652737084	0.008666157872154578,0.028236059065420614,0.02925717871219745,0.02925717871219745,0.035251625940568736
egfr	USP20_2	chr9_129868385_TGAC_T,chr9_129868775_T_C	0.001542609843192008,0.006644626432996628	0.028200134219961023,0.0362382211673806
egfr	OGT_3	chrX_71555839_AT_A,chrX_71555852_A_G,chrX_71556880_G_A	0.0015512975406232336,0.0006090442157279421,3.794330620993244e-05	0.03251106613283236,0.03051485289420325,0.02757062507023744
egfr	ILF3_4	chr19_10677068_C_G,chr19_10683073_A_G,chr19_10683954_G_T,chr19_10689074_T_C	0.0015595887966999382,0.0008443307208163777,0.0014177004651836508,0.006992884477782401	0.02905299869911714,0.023662506952371584,0.024462171404793464,0.04401306590016355
egfr	AKAP17A_6	chrX_1593528_G_T,chrX_1593824_T_C,chrX_1593829_A_C,chrX_1593416_T_G,chrX_1599467_G_A,chrX_1601004_C_G	0.0016145426205006856,0.006626142886833432,0.0006549722036186197,1.3622821646377586e-09,1.4367220837077828e-05,0.0013113963664485734	1.7500984806304813e-06,0.004424305821371996,0.031339887946813465,0.0002164120997390045,0.0019808227552202268,0.022975239267281157
egfr	HLA-DPB1_25	chr6_33084838_T_C,chr6_33086094_A_G,chr6_33086100_G_A,chr6_33086430_A_G,chr6_33086431_C_T,chr6_33086458_T_G,chr6_33086503_T_C,chr6_33086504_G_A,chr6_33086525_T_C,chr6_33084940_A_C,chr6_33084942_G_A,chr6_33084946_C_G,chr6_33084959_G_A,chr6_33086548_G_C,chr6_33086623_T_C,chr6_33086627_A_G,chr6_33086636_T_G,chr6_33086637_T_A,chr6_33084934_T_C,chr6_33086390_G_A,chr6_33086399_T_A,chr6_33086400_T_C,chr6_33086554_T_C,chr6_33086565_T_A,chr6_33084918_T_G	0.0016170360777901915,0.035517335536449965,0.03859616732889496,0.0050484605719981115,0.006920322099559346,0.04723136941351201,0.01042058063158112,0.01982161136592692,0.004676661817713314,9.909297446240884e-05,0.00013864663028350917,0.0002553757712440544,0.00010148054048444211,0.0005733999890735651,0.001447191231242919,0.0006504207970493822,0.0014159972834331574,0.0011151099996242373,1.670066308093462e-07,0.002181120675090949,0.001551134422399547,0.001551134422399547,0.00018558558739674276,0.00027961484945332547,0.04098305035004495	0.01738899621763897,0.0071970972262367875,0.0015085198751619124,0.009855204235078744,0.009159540445250336,0.0034148006003537623,0.0007725393378843376,0.00046914802311591013,0.0002211234236168895,0.01812705600921171,0.02551712776803155,0.02768815887474311,0.01961732896362046,0.00424548612011435,0.03272474670019398,0.034386513937956574,0.03829938821939845,0.02718298788851184,0.0008766728067700178,0.0010412174325617669,0.00027430911944352433,0.00027430911944352433,0.007068880728833383,0.0015589855961860727,0.0023729962607638784
egfr	ERBB2_7	chr17_39723335_A_G,chr17_39725167_A_G,chr17_39727303_T_G,chr17_39723531_A_C,chr17_39728154_A_C,chr17_39709434_A_C,chr17_39728753_A_G	0.0016350878443782172,4.136237081824547e-05,0.046602377151608726,0.0033861558195955052,0.0037588249676302338,0.03412502593916668,0.0037443415073794024	0.030443197190865717,0.016249088634527818,0.0009745478853255011,0.014043142620610086,0.002489169967351341,0.005151661954164628,0.0238332618696792
egfr	CNOT10_5	chr3_32773739_A_T,chr3_32705030_A_G,chr3_32717271_G_A,chr3_32727933_TAA_T,chr3_32704796_GT_G	0.0016526003311275095,0.0001231320148601887,0.00017728596732259782,0.009536795008099045,0.003991838672618705	0.0019461949221222566,0.0007110070373588129,0.0032142136890770555,0.009535253937430231,0.00725632017358903
egfr	BTAF1_3	chr10_91959744_A_G,chr10_91959746_A_G,chr10_92024732_G_GTTTTTTTGTT	0.0016639394777511788,0.017417232932444852,0.002725136934144748	0.0011854132574195902,0.002486161819230707,0.02294891315626264
egfr	KDM2B_2	chr12_121579961_G_A,chr12_121444386_T_G	0.0016808767205032673,0.0018129427277068664	0.04715734536774355,0.019501973878425127
egfr	OSBPL8_3	chr12_76371622_A_G,chr12_76459031_C_T,chr12_76389816_G_A	0.001685976661542144,0.0019376612844524102,0.00034069060776455845	0.010145024239484482,0.023570151478943115,0.01081801975958232
egfr	SPATS2L_4	chr2_200477598_G_T,chr2_200412421_T_G,chr2_200477943_T_G,chr2_200473083_GAA_G	0.0017077762924250339,0.005542406637614594,0.008957206491580714,0.02371288438579117	0.021972245787165747,0.03547678698863923,0.016080388811817628,0.0009052273948575811
egfr	KMT2C_2	chr7_152273692_G_A,chr7_152177504_T_G	0.0017215770748878,0.0257040166730586	0.02044755694417402,0.0007976241891358237
egfr	C3_8	chr19_6679370_G_T,chr19_6679500_C_T,chr19_6679552_T_C,chr19_6693625_A_G,chr19_6710771_G_T,chr19_6713164_G_C,chr19_6713251_G_A,chr19_6718376_G_C	0.0017242987096359706,0.011130009901872313,0.01112305118572054,0.03308700773309592,0.0007547726119911367,2.8401856724118085e-05,9.337374703033051e-05,0.00015757450123976866	0.021139612203482698,0.001328408206242609,0.0024788445051524576,0.009567716450671235,0.00949274728217466,0.015144191214707904,0.01135067374028043,0.013151961372936128
egfr	NFX1_3	chr9_33290534_A_G,chr9_33290690_G_C,chr9_33344254_T_A	0.0017340354418381332,0.00213071003554307,0.0008944872419168263	0.004533123491706767,0.03459515757598255,0.005356381351212509
egfr	KATNAL2_4	chr18_46963135_T_TGC,chr18_46969062_T_TGC,chr18_47028569_T_TGC,chr18_47069438_A_T	0.0017826363249020844,0.0002158210829164119,0.002959998960433205,1.0166082620431142e-06	0.023566439092900897,0.042581318341999685,0.01792891562738572,0.04594422713064072
egfr	PLRG1_8	chr4_154538042_A_T,chr4_154539961_T_C,chr4_154540535_A_C,chr4_154540996_A_T,chr4_154544383_A_G,chr4_154545783_T_C,chr4_154546035_A_G,chr4_154548807_G_GA	0.0017837327552204187,0.0022747756662197635,0.013232282684609756,0.006089524083842604,0.023466965037692716,0.011286717487280188,0.015766497021373137,0.001132424851953552	0.0025156591482322463,0.003876861205834139,0.008064183834782563,0.004736898325652559,0.004629934695328492,0.00625636632504058,0.006403275082048386,0.0051675452547446255
egfr	EDN1_2	chr6_12295840_T_G,chr6_12295843_T_G	0.00181409210724337,0.0002763328454078789	0.024241257142762068,0.012273310260196891
egfr	RABEP1_2	chr17_5381248_TAA_T,chr17_5361621_C_T	0.0018150712755665734,0.004152920156402154	0.007056745600928623,0.01880219353285387
egfr	RUNX3_2	chr1_24907301_T_G,chr1_24907326_T_G	0.001835528705698884,0.0008816631461578386	0.0479402881785652,0.03367486268556343
egfr	ARID3A_2	chr19_929678_G_A,chr19_965056_A_C	0.001844502898018781,0.0038221459346221604	0.0024448512910076343,0.038475803182823655
egfr	SETD2_6	chr3_47037622_G_A,chr3_47083895_G_A,chr3_47084411_A_C,chr3_47084426_CT_C,chr3_47101417_TCC_T,chr3_47121171_A_G	0.0018886443163515503,0.0005724676673950148,0.0018507014329319895,0.002298087295161151,0.0018577181187481573,0.000573845912909288	0.000977617083994294,0.008205866594339892,0.008011204119723829,0.009083566444260623,0.0015764712914139378,0.0002475067417184235
egfr	MYO1E_4	chr15_59272288_G_C,chr15_59223315_G_A,chr15_59178167_C_T,chr15_59138181_A_C	0.0019255092745879315,0.027929898310990055,0.00031389151980896725,0.04411515555617615	0.006181875879725325,0.0073567891788311425,0.014590984354000915,0.000506485287819266
egfr	SUGP2_5	chr19_19024510_A_G,chr19_19025732_C_T,chr19_18994964_G_A,chr19_19026233_T_A,chr19_19010089_T_G	0.001983285518752092,0.002941993796204625,0.01284029709782453,0.0020741831309949127,0.0008037924072482433	0.040831519054544435,0.008182273259557721,0.005749298256034085,0.007605074821863024,0.027745888328438603
egfr	KLHL18_3	chr3_47319581_T_G,chr3_47344095_C_A,chr3_47322481_G_T	0.0021891626387678365,0.0006911454072889093,0.0001458644297550943	0.013218876001835087,0.0063137500959640856,0.018113274866617776
egfr	TYSND1_2	chr10_70138599_C_T,chr10_70140172_G_A	0.002210990629147794,0.0039640911222843436	0.009659099597965872,0.027700702531791875
egfr	EIF1B_5	chr3_40309993_C_T,chr3_40311393_C_T,chr3_40311934_CAG_C,chr3_40311768_T_G,chr3_40309649_C_G	0.0022271726409335488,7.503385234156634e-05,3.177548305907501e-05,2.1365604310883664e-06,0.006831469965345718	0.005496962588873379,0.0028348307389023737,0.0036905138907599726,3.949648255514959e-06,0.04857611284248277
egfr	C14orf79_2	chr14_104991443_T_G,chr14_104992803_A_C	0.0022393155386724074,0.009479451263550959	1.7720854995940125e-07,7.586102006604381e-07
egfr	SLC52A3_2	chr20_761203_A_G,chr20_763790_T_G	0.002271842149158581,0.0019785326127115858	0.0003747217630289052,0.003089764091274667
egfr	HDAC5_2	chr17_44087216_A_G,chr17_44077102_A_G	0.0022775299741103626,0.009100177186215046	0.03161998848113075,0.021561030479614426
egfr	TCF7L2_4	chr10_112951117_C_T,chr10_113165703_A_C,chr10_113165557_GA_G,chr10_113141157_T_G	0.0023062734857754803,0.006196689121801137,0.00015949311848004983,0.01042058063158112	0.01060529288873283,0.008309178089758909,0.04233413143117931,0.004504822920252362
egfr	DSP_2	chr6_7577915_A_C,chr6_7581379_A_G	0.002345981327408041,0.02625851263459552	0.0018316675069518392,0.005935959963292785
egfr	GAS7_3	chr17_9943314_G_A,chr17_9943407_C_A,chr17_9940079_A_C	0.0024862474118096554,0.02161659825841676,0.01209844734945125	0.014304203615809547,0.007643530014898026,0.02182596122662912
egfr	ARHGEF5_5	chr7_144365079_A_C,chr7_144371121_T_C,chr7_144371117_T_G,chr7_144364997_T_C,chr7_144365475_T_C	0.0024945926126355923,0.02354548207827752,0.006211748094610735,0.002934715516170928,1.727507617843059e-06	0.02343547139067424,0.007520412833757487,3.130275501973943e-06,0.02778730920062768,0.003065464879158348
egfr	PTPRU_3	chr1_29275579_A_C,chr1_29310715_T_G,chr1_29255395_A_C	0.002539773248455689,0.0077226993558171956,0.0009778041944005973	0.007805553893565897,0.021084479691732515,0.046498222792818684
egfr	TTC39A_2	chr1_51288088_T_G,chr1_51295930_G_T	0.002570863553329518,3.4909921895622464e-05	0.0009000808652072745,0.009859747746545187
egfr	KRT15_3	chr17_41516910_C_A,chr17_41518370_T_G,chr17_41518744_A_C	0.002573274763251264,0.011567941016623695,0.003420135618507444	0.005435309336568784,0.004600527769071169,0.020891294013713143
egfr	UBXN8_5	chr8_30744093_TC_T,chr8_30744288_C_T,chr8_30751256_A_G,chr8_30751544_T_G,chr8_30751561_A_T	0.002591192476579632,0.0006909486125387932,0.02443874890142141,0.03582659928743899,0.03582659928743899	1.0603773748192244e-05,4.865545060608271e-05,6.152112049146202e-05,3.811929186552625e-05,3.811929186552625e-05
egfr	SMARCA4_3	chr19_11003321_G_T,chr19_11010261_C_T,chr19_11026459_T_C	0.002630441388397466,0.010463060303081006,0.010088756192701873	0.010970724428159849,0.007818649393052565,0.008366105586796981
egfr	PSMD6_2	chr3_64018733_C_CA,chr3_64023832_T_C	0.0026976125076584256,0.009878175034845338	0.010870617478385693,0.0044822108745555264
egfr	CCDC18_7	chr1_93226524_AAT_A,chr1_93232665_C_G,chr1_93180876_T_C,chr1_93221838_T_C,chr1_93239253_G_A,chr1_93226314_TG_T,chr1_93180563_T_G	0.0027123682464393244,0.0016657739488188466,0.0033797977817805816,0.0015978624867728733,0.002134999320804664,0.013590020119742256,0.003793743444563949	0.04835531632243841,0.0045740699346053185,0.00032147121850177287,0.0017542576026547778,0.0017542576026547778,0.003812032810040999,0.0440564257256616
egfr	MKRN2_2	chr3_12572367_T_C,chr3_12576770_C_T	0.0027864675750747985,7.698740851570175e-06	0.0004133954800997532,0.00023875055451781275
egfr	POU2F2_2	chr19_42122415_A_C,chr19_42116791_T_G	0.002831354927429977,0.00132487414614545	0.0009318465407261826,0.03195305321524156
egfr	CSNK1G2_2	chr19_1941300_C_CG,chr19_1978367_A_C	0.002838297409364801,0.002057750736247525	0.0019266812436141687,0.04165592627236607
egfr	NADK_4	chr1_1754601_G_T,chr1_1755504_T_C,chr1_1755523_C_T,chr1_1757030_C_G	0.0029196774804306136,0.0022487075080235863,0.0010425578675322944,0.004582127513664698	0.031872533533518106,0.005752610352558396,0.0031781335571060463,0.03556781287056178
egfr	CD151_2	chr11_837662_TG_T,chr11_835877_C_T	0.003028852216804449,0.04104019245722205	3.3851264417503082e-06,0.005759250847020773
egfr	ATP5A1_9	chr18_46098069_T_C,chr18_46086016_C_T,chr18_46086895_T_C,chr18_46086986_C_A,chr18_46087562_T_C,chr18_46088355_G_T,chr18_46090014_T_C,chr18_46098295_T_G,chr18_46090084_G_T	0.0030434677700528394,0.0004952827031339936,0.007810554102540824,0.000648733348082285,0.013897849420604671,0.002385765549363269,0.0010062790676919331,0.005315177457540565,0.01959258956571804	0.0003047097440701736,0.0142075393191002,0.036323160579493724,0.013872652612254888,0.0036567482317310593,0.02085147005163321,0.01507674177782532,0.03454712220311499,0.007087269321528623
egfr	ACTR8_2	chr3_53876892_G_GT,chr3_53876872_GA_G	0.003050264516832101,0.008934315374097621	5.979539416096826e-07,0.005988354207232076
egfr	KDM4C_3	chr9_7105548_G_C,chr9_7170165_G_A,chr9_7174813_T_A	0.003056285777006115,3.848309807154845e-06,0.028252899669062883	0.04853749604959928,0.04549941716484139,0.006907446061910031
egfr	AZI2_2	chr3_28331971_C_CA,chr3_28340396_A_T	0.0031048857689516462,0.003592307504254993	0.014552320913166257,0.004305743220750069
egfr	SERTAD4_2	chr1_210241533_TC_T,chr1_210241536_T_C	0.003132119859215549,0.009639231593611885	0.019963608830813308,0.006491338228956634
egfr	USP15_4	chr12_62302696_T_G,chr12_62383784_G_T,chr12_62404146_G_T,chr12_62335441_G_C	0.0031338510061822643,0.014094139089898441,0.0031672583932668176,0.002293994252085232	0.00033081922207003954,0.0033557619531166464,0.00033479875073063453,0.039619833047337696
egfr	DOCK1_3	chr10_127012556_G_A,chr10_127444251_G_A,chr10_127248024_G_T	0.0031585127425178675,0.027688640963832358,0.0004879172723173928	0.004938898221400919,0.007801850145866487,0.020184142497530616
egfr	ITGB4_4	chr17_75736347_G_A,chr17_75739839_G_A,chr17_75742534_T_C,chr17_75754823_A_C	0.003162157220078509,0.008328692436238487,0.007894779942929558,0.009860822677928005	0.01217344559335353,0.002457354260511787,0.01159864028497844,0.005496381411893582
egfr	ZDHHC17_2	chr12_76843188_G_A,chr12_76815330_A_G	0.0032793703796479517,0.0004434027342669209	0.011228793208829205,0.0047926477879100746
egfr	STEAP4_2	chr7_88282586_G_A,chr7_88283906_C_T	0.003287923696320924,0.0091566014690908	0.020956268813510096,0.020511289316670928
egfr	SON_2	chr21_33553093_A_C,chr21_33553095_T_C	0.003287986051022628,0.0002182856164179604	0.023262781799198717,0.04085529307129965
egfr	SUZ12_2	chr17_31937449_T_G,chr17_31937443_C_G	0.0032919118028606463,5.6901277653871055e-05	0.001414433092115542,0.02301260051890533
egfr	ZNF708_5	chr19_21294577_C_T,chr19_21309149_T_A,chr19_21309260_G_A,chr19_21294601_T_G,chr19_21310453_A_T	0.003305225750188495,0.0035049021956979373,0.004520698246333428,0.0002495831365867789,0.0067675270617948155	0.007544201865148675,0.008126720123629898,4.891895383413758e-05,0.0371668734968966,0.010566885319869566
egfr	NPAT_3	chr11_108173261_C_T,chr11_108188273_T_C,chr11_108222481_A_T	0.003344965508099712,0.00917775939993597,0.039703241026176714	0.002496786878352684,0.04574657942913745,0.0037813176541691743
egfr	HSPG2_4	chr1_21848107_A_G,chr1_21857246_A_G,chr1_21854055_T_C,chr1_21885485_A_C	0.003347609104205378,0.0006068526113653472,0.003704007084337551,0.00357256954025205	0.02697977272492986,0.03734459078034153,0.0018455746031783011,0.028105372966297285
egfr	TOP2B_6	chr3_25618603_G_GT,chr3_25620066_T_TA,chr3_25630287_C_T,chr3_25632344_A_C,chr3_25632600_C_A,chr3_25638247_T_C	0.0033763968792717173,0.008450908635462133,0.0012336549489001688,0.00024044846753362568,0.0010363758807633305,0.0007533307901546944	0.009406841430847504,0.006029442482514222,0.011303133266640238,0.01883862996744124,0.018119501937010576,0.00877690000990295
egfr	MUC16_3	chr19_8894929_A_T,chr19_8979498_T_G,chr19_8957088_C_T	0.0034029575974152395,0.00041258558252529193,0.001514661605616884	0.03041637790901308,0.002432253712629655,0.03213344574711092
egfr	TMEM144_3	chr4_158244471_A_C,chr4_158253356_T_G,chr4_158253361_T_G	0.0034876691228988683,0.0005647077594982514,0.0008326481477321537	8.607739077270522e-05,6.799118981257274e-05,0.0018072956471693355
egfr	SDC1_2	chr2_20204203_T_G,chr2_20202279_A_C	0.003538404752618725,0.0156379764488537	0.012274967718012342,0.005607450656810002
egfr	RBM6_7	chr3_50054242_G_T,chr3_50054246_C_T,chr3_50054250_C_T,chr3_50054257_G_T,chr3_50054263_T_G,chr3_50075177_T_G,chr3_50066484_G_A	0.0035570559373772188,0.00580221866025999,6.528791603289091e-07,0.001554315699435568,0.0007276852324929738,0.008508212434548797,0.002518709860742996	0.0124136469122058,0.0004024483543288937,3.272618868931358e-05,5.8729619078742086e-05,0.00033057063887385755,0.000930075295183941,0.014325869585835831
egfr	FIP1L1_2	chr4_53377738_T_C,chr4_53414538_G_GA	0.003618394551763958,0.000808630514933739	0.020612870650917825,0.014620279830838013
egfr	BAZ1A_6	chr14_34773800_G_A,chr14_34761774_C_T,chr14_34761902_A_T,chr14_34771458_C_G,chr14_34780118_A_G,chr14_34862082_G_A	0.003674207621815091,0.00048794862757524084,0.0004529362621637724,0.00048794862757524084,0.0004529362621637724,0.0008633899521319537	0.020819109086183382,0.029434275834813995,0.038030144241646684,0.029434275834813995,0.038030144241646684,0.029434275834813995
egfr	ABLIM1_2	chr10_114468289_G_T,chr10_114613516_C_T	0.003679575880821695,2.068694569003633e-05	0.013324532381057309,0.007365229118612223
egfr	KCTD11_3	chr17_7356629_G_T,chr17_7356036_T_C,chr17_7353417_T_G	0.003754571069046404,0.00017366868689943718,0.0012390848435611386	0.04600482755406116,0.034157938547959045,0.0012683162409826913
egfr	MICALL2_5	chr7_1442358_T_G,chr7_1448634_T_G,chr7_1438692_G_A,chr7_1438940_G_A,chr7_1434765_T_C	0.0037969325863282813,0.03384278289950645,0.029060946696468106,0.029060946696468106,0.0032003913710269877	0.003849439864891702,0.00957207447144348,0.001706040259270731,0.001706040259270731,0.009156797658911076
egfr	RFC1_4	chr4_39304977_A_C,chr4_39317086_A_G,chr4_39327482_G_A,chr4_39366034_T_C	0.003804607068014229,0.002653298567768597,3.2670263647126826e-05,0.042208647376131	0.0020300192179148733,0.00027426635734190813,0.008638827908989666,0.0022061266378501725
egfr	AP1M2_5	chr19_10572926_C_T,chr19_10579645_C_T,chr19_10587097_A_G,chr19_10587125_G_T,chr19_10579014_TC_T	0.0038087692058226532,8.991675208563765e-05,1.1792724900645332e-05,5.261102684897293e-05,0.001877531631940374	0.02140839327697613,0.010527568877864577,0.0015316982164778213,0.023908631854345174,0.00821632833656041
egfr	RPS23_2	chr5_82278173_C_T,chr5_82278363_C_T	0.003957786808705407,0.0008315075457503006	7.911328672036997e-05,2.402875788954321e-05
egfr	BARX2_2	chr11_129436792_A_C,chr11_129436677_C_T	0.004015743982394933,3.8908364285059496e-05	0.0011297752143511178,0.006988734279853065
egfr	LRRC1_3	chr6_53913863_T_G,chr6_53920478_C_A,chr6_53899709_T_G	0.004131339558552957,0.0030469251357492584,1.3663885062737747e-07	0.02863343366704425,0.016849492489466617,0.0009777953947081833
egfr	POGZ_3	chr1_151423306_T_C,chr1_151407350_A_C,chr1_151459156_T_C	0.0041738932600083895,8.993795886819927e-07,0.008612349643764727	0.020015181832936737,0.02909488569964382,0.009809035888391762
egfr	PRKCI_2	chr3_170275187_CTTT_C,chr3_170263168_CAAAAA_C	0.00425052374891476,0.002760121279997125	0.00012798467543814748,0.021989752739530143
egfr	PGBD1_2	chr6_28296652_T_G,chr6_28298177_A_T	0.004288328285551539,0.00932669296817631	0.005702673764439882,0.020264770709017343
egfr	LGALS8_3	chr1_236537373_GAGC_G,chr1_236539197_AGTTT_A,chr1_236551447_T_C	0.00435552243438307,0.02490692830672263,0.005408439057885871	0.0007287918934518675,0.002689054589007359,0.013132223069499007
egfr	CYP4F11_7	chr19_15913852_G_C,chr19_15914366_C_T,chr19_15924707_G_A,chr19_15927524_G_A,chr19_15927580_G_T,chr19_15929482_A_G,chr19_15929663_T_C	0.004494422448579687,0.004118655653677505,0.009014030424870815,0.007737694175519336,0.005296914283554929,0.006573618747648885,0.0045029584577228	0.01037304937937457,0.022954596803030098,0.0124267741256932,0.011141708950444295,0.011312909542474079,0.016341169913201302,0.013422572430360932
egfr	ZNF24_3	chr18_35337816_G_GA,chr18_35337680_T_C,chr18_35344446_G_A	0.004517003572403403,0.00020451573869716152,0.02552298264953765	0.012709161524744772,0.04404021168973007,0.008269738810110396
egfr	ANKS6_2	chr9_98796162_G_A,chr9_98778486_A_C	0.0045700537784898465,0.009257993261520582	0.047044500480316616,0.03370066145919663
egfr	POLR2B_6	chr4_56995192_C_T,chr4_57010789_G_A,chr4_57015549_G_A,chr4_57025073_G_A,chr4_57005234_AT_A,chr4_57023798_AT_A	0.004738473697291275,0.00020500907676743697,0.0003428363180097953,0.00033030198738810576,0.000896266309671023,0.010078450270635015	0.00041802227600176717,0.03709404459710368,0.03851787302536296,0.03254648423802934,0.03704331970217288,0.007472844031288456
egfr	CDC42BPB_3	chr14_102939620_T_G,chr14_102952453_T_G,chr14_102945931_T_C	0.0049774861882444345,0.0002680622756333545,0.004938189506165365	4.775637628078603e-05,0.003315245095495249,0.001918499391114136
egfr	WDR62_3	chr19_36058788_C_T,chr19_36084743_G_A,chr19_36094002_C_T	0.005088637492213912,0.016915078735087723,0.007443859285838674	0.0005331846126391098,0.000415677937125236,0.0005211199976091131
egfr	PLCB2_2	chr15_40298884_T_G,chr15_40297623_G_A	0.005308041472208479,0.0013941969299030182	0.025458039339188058,0.04960868971387879
egfr	ZEB1_4	chr10_31461157_A_C,chr10_31521191_A_C,chr10_31521414_A_T,chr10_31461247_AT_A	0.005342806393282525,0.01137703502325166,0.0014780611664163069,5.800757504246017e-05	0.013618649263675358,0.006377825075174489,0.011119739548999731,0.0019400920584000448
egfr	NDUFAF4_2	chr6_96891399_CA_C,chr6_96896910_G_A	0.005489763925784804,0.0005269475943804068	0.01909002509011261,0.009369364198285348
egfr	PHIP_9	chr6_78947674_G_A,chr6_78954723_T_C,chr6_78955031_T_C,chr6_78955493_T_A,chr6_78969860_A_G,chr6_78985312_C_T,chr6_78998206_C_T,chr6_79043075_T_C,chr6_78947709_T_C	0.005530164992886238,0.00548954353554207,0.01455660590235654,1.6913729880297845e-05,0.0035647193470514853,0.005289398736036421,0.001837097400913216,0.004209432623363282,0.02442132743404569	0.0010048550446085317,0.00648756713202656,0.0009432749408838033,0.009594339103514994,0.0017203137452171692,0.0007527047164367361,0.006763071535609179,0.0016364259457283912,0.0006553233953188175
egfr	C6orf203_2	chr6_107044172_C_T,chr6_107051038_GTTTTC_G	0.005594780806642859,0.010350958813062314	1.8543097341742985e-05,4.7416804336943046e-05
egfr	RIOK1_2	chr6_7390137_G_T,chr6_7410502_GT_G	0.0056620989198510035,0.009940460227242327	0.004558417307934729,0.0007644747214841657
egfr	STX2_3	chr12_130796169_T_C,chr12_130821769_C_G,chr12_130827084_G_A	0.0057763908603848755,0.0026232291323331123,0.0017127068028307182	0.03019238327054641,0.01065610617547119,0.004236660791662807
egfr	DOCK9_6	chr13_98797273_A_G,chr13_98888796_T_A,chr13_98848509_C_T,chr13_98902701_G_A,chr13_98883901_TA_T,chr13_98977850_C_T	0.005927598026328671,1.199291147137571e-06,0.00025790841294325934,0.0030628908663900517,0.003688722979152048,1.1373148571396284e-05	0.006004783016582045,0.01781055671478815,0.005840989451706359,0.025244747630348088,0.020609371467392473,0.01526774575825921
egfr	ADAM15_4	chr1_155056046_G_A,chr1_155058081_A_C,chr1_155058900_C_T,chr1_155053372_T_G	0.005983172351155387,0.003608774130493322,0.02011005006826893,0.013070176515727179	0.02587883400458268,0.038829781369162535,0.006114928575864872,0.005438593481843924
egfr	ZNF430_3	chr19_21020746_C_T,chr19_21033730_G_A,chr19_21022725_C_T	0.006039060973644978,0.0017404412233575466,0.0032443389741318627	0.0014493947676260713,3.875366882434858e-05,7.931044376997757e-06
egfr	SLC41A2_2	chr12_104866497_A_G,chr12_104805360_A_C	0.006042414055759166,0.003878181222682689	0.04584324420776458,0.01814258498012539
egfr	ARHGAP5_2	chr14_32092970_T_C,chr14_32154828_T_C	0.006122997092230283,0.00899034241039037	0.000109609141495362,0.0028505632724505807
egfr	CTSB_5	chr8_11848168_C_G,chr8_11853379_G_C,chr8_11847933_G_T,chr8_11852665_T_C,chr8_11848361_G_A	0.006170091093918575,0.013883502523880249,0.013105854756963943,9.23481096080534e-05,0.0030280965583678638	0.010885538500044391,0.006363373856765906,0.00949712914495799,0.00465817682934427,0.02101769256107376
egfr	INTS10_7	chr8_19824136_G_A,chr8_19825034_A_G,chr8_19825081_A_G,chr8_19832122_T_C,chr8_19823225_T_C,chr8_19823468_C_T,chr8_19820404_G_A	0.006249656348718163,9.755626466214517e-05,0.0032595992956769558,1.3994534854585697e-05,0.01825573585413804,0.0007017951945376175,0.0019656324021710553	0.004251571736144285,0.006724158153343274,0.02600076241538477,0.015595096037435119,0.0063513471360198154,0.004329630966639476,0.012844960200188478
egfr	CHAF1A_3	chr19_4406163_G_A,chr19_4442339_C_T,chr19_4422720_A_G	0.0064074940660708,3.653207387854824e-06,1.4819698101788669e-05	0.0008752119921859383,2.142565869765625e-07,0.024620616607439628
egfr	MDC1_2	chr6_30711769_A_C,chr6_30704316_T_G	0.006463206071893797,0.0019882207404644673	0.0020262441930086923,0.0013599597266763966
egfr	DYRK1A_3	chr21_37420484_TGGG_T,chr21_37506256_A_C,chr21_37505200_T_G	0.006470184695707864,0.007166152604563953,0.0018009306683812387	0.004141112427822946,0.023367448843283026,0.006729513952629108
egfr	SMPDL3B_2	chr1_27949055_T_G,chr1_27956116_T_G	0.00686332660241626,0.005864140422713154	0.0015905760666496795,0.0137996143213625
egfr	EVPL_2	chr17_76023471_A_C,chr17_76023459_T_G	0.007000637494837062,0.0007672223327735785	0.005291001652021031,0.010508474240463184
egfr	TOM1L1_5	chr17_54914767_TA_T,chr17_54930294_T_G,chr17_54936619_A_G,chr17_54936871_A_ATTAAG,chr17_54949462_TAAAAG_T	0.007038383297527345,0.0050109411285773646,0.00021710780579647815,0.00028231096361921765,0.00012667235189768908	0.04878127910267323,0.03275406093703293,0.014250045450198362,0.01731618533169237,0.009468652758198769
egfr	PPP6R2_6	chr22_50437806_T_C,chr22_50444323_CT_C,chr22_50438097_C_G,chr22_50439767_G_A,chr22_50444161_G_A,chr22_50435068_C_T	0.007051784222833177,0.023269327181446267,3.439001444964778e-05,7.581666224780631e-05,3.643039740627613e-05,0.0008291832461198612	0.0008491344323951777,6.519259302157606e-08,0.02539141451283096,0.0453099522882128,0.048741469250829166,0.04553862958411738
egfr	DAB2IP_2	chr9_121772524_T_G,chr9_121760326_A_C	0.0070915742180131395,0.007778717869708281	0.02191587566106909,0.01751891495836218
egfr	WRN_8	chr8_31096749_C_T,chr8_31124455_G_T,chr8_31141606_C_T,chr8_31167122_C_T,chr8_31068263_T_G,chr8_31096728_GT_G,chr8_31081188_G_A,chr8_31154721_C_G	0.0071839350828315045,1.9744778112725726e-06,3.7195190403966525e-05,0.0005948019596535545,1.4689350346055224e-05,0.009117602293234885,4.455137121499956e-06,0.015467137724934844	0.015593392890488516,0.0002318154176456728,0.000309347551379363,0.008293074145156037,0.01874901447901884,0.0010432049093381938,0.02919802325158393,0.008229549817641594
egfr	SEC63_2	chr6_107876794_A_G,chr6_107876670_C_A	0.007209006342709896,0.0019416198580565237	0.0015670897229372802,0.02957724273333363
egfr	MAU2_6	chr19_19336127_G_A,chr19_19338794_G_A,chr19_19338877_G_T,chr19_19342712_T_G,chr19_19342751_C_A,chr19_19344019_G_A	0.007212671514055286,0.000960361991019274,0.0009059794395416026,0.0008876467494768484,0.0008876467494768484,0.001002378802893851	3.528738486135461e-07,1.9278481053706903e-06,3.174590417336852e-07,1.942933711490239e-07,1.942933711490239e-07,3.6691446641905493e-07
egfr	CDCP1_3	chr3_45091085_A_T,chr3_45091145_T_C,chr3_45095296_A_G	0.007224118191596861,0.003521903825993761,7.820303910973087e-07	0.01528693636083844,0.0025128061409562703,0.034457598045182634
egfr	NKTR_2	chr3_42630618_G_C,chr3_42636885_C_A	0.007397151891706983,0.004629789663279317	0.0027059941965995107,3.766470432445502e-05
egfr	GSN_3	chr9_121321305_A_C,chr9_121326911_A_C,chr9_121282717_C_T	0.00754758939906495,9.99197364773904e-05,0.008701863324990747	0.0036521684936499576,0.014858234163842209,0.04144642618836994
egfr	MTR_3	chr1_236885200_A_G,chr1_236897645_CT_C,chr1_236812798_T_G	0.007571674596968512,0.00019121697493807043,0.006559116282295972	0.013876029031175869,0.019195378846888603,0.028819324921187783
egfr	DNAH1_4	chr3_52395506_T_G,chr3_52398167_T_C,chr3_52375405_A_G,chr3_52394972_C_A	0.007807586400497246,5.188940804112937e-07,0.028701683809333287,0.04830043674512241	0.020152041638368784,0.04601002692990365,0.006840623405991567,0.005200470677837818
egfr	NDUFS7_6	chr19_1388539_C_T,chr19_1389518_C_A,chr19_1390758_C_A,chr19_1391101_A_C,chr19_1387920_T_G,chr19_1387934_A_G	0.007902298175424828,0.01802139597834927,0.005968824663343653,2.816150837753928e-07,0.0031818920109542336,0.02651542479567508	0.004445598304300863,0.004267266689815653,0.007929745168935362,0.02277060279294577,0.0061684138287453226,0.0002841985871883526
egfr	TLN1_4	chr9_35711809_G_T,chr9_35712826_G_A,chr9_35700530_A_AGTTT,chr9_35707057_C_T	0.008212937465719947,4.3027034258145176e-05,6.892028990051384e-06,1.5583116688212289e-06	0.03705209858981909,0.019628446580987526,0.03215388610263167,0.026823292872806558
egfr	PARPBP_3	chr12_102164766_G_C,chr12_102165930_A_C,chr12_102195841_T_TTAAAAA	0.008239841603573375,0.048432585939195916,0.009577111829889028	9.259289657162176e-05,0.0008692851756599481,4.1069065265654646e-06
egfr	FZD6_2	chr8_103300204_A_G,chr8_103318860_G_C	0.008531191339496548,0.00031326302687667253	0.02679919317294273,0.01810032651868897
egfr	ITPR1_10	chr3_4651972_C_T,chr3_4673329_A_C,chr3_4712028_A_G,chr3_4814550_G_A,chr3_4645814_T_A,chr3_4652327_G_A,chr3_4653996_G_A,chr3_4717319_C_T,chr3_4652159_T_G,chr3_4516699_C_T	0.00859416859519535,0.0036591352908788796,0.002472562485621646,0.0007540687837519184,1.174056333280529e-06,1.6973582056331476e-05,0.00018073915749960563,0.025102582779245618,0.0060202139881954326,0.01485572695651343	0.02221500748211688,0.028276024726866744,0.031417032356405285,0.020003750528966732,0.02165052204755015,0.04826424992681114,0.04219875731949733,0.00956347809995603,0.032544122080128725,0.04748127629652489
egfr	LAMA5_11	chr20_62307035_T_C,chr20_62308863_T_C,chr20_62315711_A_C,chr20_62325178_T_C,chr20_62327158_G_A,chr20_62327540_T_G,chr20_62310033_T_G,chr20_62327738_A_C,chr20_62332572_T_G,chr20_62327734_A_C,chr20_62345568_A_G	0.008632920752406494,0.014295751572041776,0.02909024968748458,3.555862255130917e-08,2.9240346346210547e-06,0.00712140384613043,1.5666190990300454e-05,0.019613193736301028,0.03355260503997278,0.034148373295335904,1.0743773421509558e-05	0.008839994985818419,0.003401604212977075,0.0003409731985327621,0.010970601799299722,0.037454561614064526,0.04839717926265442,0.00011553533752570969,0.00016041497097470358,0.00634985461358608,0.00014957483336764524,0.02125937044218393
egfr	MAPRE2_2	chr18_35132001_G_GT,chr18_35070377_A_G	0.008697538540744818,0.0008936827603968188	0.027950082818089944,0.013874344261478143
egfr	PCM1_14	chr8_17938873_A_G,chr8_17938874_C_T,chr8_17947156_G_A,chr8_17957171_G_C,chr8_17962063_C_T,chr8_17962252_A_G,chr8_17972247_C_CAA,chr8_17993739_C_A,chr8_18010736_C_A,chr8_18014089_T_A,chr8_18014110_A_C,chr8_18027462_G_A,chr8_18027582_T_C,chr8_17963329_A_C	0.008797381653836422,0.008797381653836422,8.592105380343799e-09,9.956680768337928e-13,6.195811157969624e-08,1.8937727055349602e-07,0.012906783621554044,0.00024859599240286334,0.0005752822575338514,1.5559989504674227e-05,2.7991275648315256e-08,1.0617795138512517e-06,1.3096196909220091e-08,0.013270249004941498	0.0286880097933444,0.0286880097933444,0.005755604603604279,0.003664181277087841,0.003941798080137453,0.000146676782393952,0.003377252281952908,0.0004892784845984415,0.01725609483145887,0.00016889400218637822,0.0005696202104790463,5.9466930864771254e-05,0.0032089265919612235,0.004113314671783447
egfr	LAMC2_2	chr1_183207851_G_T,chr1_183207864_G_T	0.0090311817049441,0.0010913836051824374	0.02500420336879176,0.034260068788679536
egfr	FAT1_2	chr4_186706505_TAAAAAA_T,chr4_186628213_A_C	0.009108698459398929,0.008101657943453211	0.02585265305545377,0.01860566173117391
egfr	SQSTM1_3	chr5_179833009_G_A,chr5_179822433_T_C,chr5_179832842_G_C	0.0096926694417795,0.004856219591816439,0.0277352874184494	0.03979973429187952,0.0024949336391905503,0.0024314650981475784
egfr	CCDC25_3	chr8_27736133_T_C,chr8_27740525_GA_G,chr8_27740655_A_G	0.009721303652590912,0.0012870249285031976,0.019736174159448082	0.012214514779241077,3.013644227200994e-08,0.009242113446549792
egfr	PTGFRN_2	chr1_116949272_C_G,chr1_116985006_T_C	0.009786238032301352,0.0007152254747991232	0.04386987327886,0.015007302908998025
egfr	CUEDC1_2	chr17_57872703_C_T,chr17_57873465_G_A	0.010263213673294223,0.0029406902030506186	0.0013582824059236026,0.00965828204249475
egfr	POLR3D_5	chr8_22247989_T_C,chr8_22247116_G_A,chr8_22247770_T_C,chr8_22250473_A_G,chr8_22245170_T_G	0.010361813952662016,0.040760845043798406,0.010265363996485286,0.010265363996485286,0.03202227743017228	0.0015081231813274575,0.0005996811951877831,0.0014851724380103976,0.0014851724380103976,0.0034846025589736784
egfr	MDN1_10	chr6_89661483_G_A,chr6_89662267_C_T,chr6_89680724_C_A,chr6_89712908_G_C,chr6_89728912_G_T,chr6_89745710_T_C,chr6_89819438_A_G,chr6_89819440_C_G,chr6_89819446_A_G,chr6_89656810_T_C	0.011142557737209857,0.019733545814518076,0.00671054318104286,0.009319633314546674,0.029067614736169964,0.014718502010945343,0.03726926768860217,4.658109373380921e-05,0.00043794075690144836,0.001077236984005633	8.702195141061847e-05,4.241840867716095e-05,3.792323014139115e-05,0.002381685713249437,0.003051989681616468,0.0024784505977437274,0.002315253787970113,0.00030565312846269634,0.0005358395597195241,0.045388379703494304
egfr	ZNF407_5	chr18_74635526_T_C,chr18_74881076_C_G,chr18_74881080_A_C,chr18_75064165_G_A,chr18_74881141_G_A	0.01132130975657727,0.03691411059827635,0.002564188916256107,0.00027018930993972406,0.0024107982547803396	0.0030145474545959137,0.009890224680183182,0.03975077518004473,0.0037574487440396095,0.018926593122392126
egfr	C18orf21_2	chr18_35977490_T_C,chr18_35973023_A_G	0.011570265284110644,0.04350573719131977	8.814319140246499e-05,0.009001638536085271
egfr	DNHD1_2	chr11_6566998_G_A,chr11_6502909_T_C	0.01157615377505105,0.024706472106323003	0.003441011845932656,0.0051368432267910715
egfr	KCNQ5_2	chr6_72622312_C_G,chr6_73194868_A_C	0.011667048329227513,0.008556892857902195	0.005821769162034106,0.002035847347947271
egfr	USP7_3	chr16_8916969_T_TA,chr16_8921401_T_C,chr16_8919178_A_G	0.011921515809972538,0.0007259106255980508,0.00985787434616614	0.007935686984078177,0.03489258945527392,0.01271404693174776
egfr	KRT19_2	chr17_41524128_T_G,chr17_41524420_C_T	0.012145831162385651,0.02329208372328466	0.006794604788851329,0.0075159453943370955
egfr	CHD4_2	chr12_6598281_A_C,chr12_6596093_T_C	0.0122076861217219,0.004382346617449564	0.0023450404288739924,0.005341196474657028
egfr	TRIO_5	chr5_14270972_A_C,chr5_14380924_T_A,chr5_14287139_AT_A,chr5_14485052_GTTTT_G,chr5_14304660_GA_G	0.01228372579415868,3.324291735916414e-05,0.01866091088461598,0.0021188750196952637,0.001000539371629746	0.0041763005884629285,0.009266068007448034,4.1269944199248776e-05,0.00011802420018250479,0.0066869864395857175
egfr	NR2F6_3	chr19_17232488_A_G,chr19_17240807_T_C,chr19_17240813_T_C	0.012426826069594731,0.008405600723765323,0.0104569397340928	0.0005711072972571918,0.006907234943082266,1.728226736131038e-05
egfr	HNRNPH1_2	chr5_179621204_T_C,chr5_179614784_GAAAAA_G	0.012466319116509934,0.03611121611218025	0.0008981889773064157,0.009729395921872941
egfr	POLDIP3_2	chr22_42585672_T_C,chr22_42585502_A_C	0.012811765150489051,0.04394982419601543	3.6252104008481515e-06,0.004353728585767742
egfr	CASKIN2_4	chr17_75501358_G_A,chr17_75501713_T_C,chr17_75503616_T_C,chr17_75508335_T_C	0.01313679969802845,0.0005650477736965628,0.0014275310574789414,0.004128633364054907	0.002427426610400476,0.00023272703416067725,0.00689117538932749,0.024705224854909082
egfr	ZNF557_3	chr19_7083618_A_G,chr19_7083750_A_G,chr19_7074861_G_A	0.014332802500416091,0.016198364111666076,0.009991664044269358	1.6329734686551152e-07,4.640996358288638e-07,0.019872633283012617
egfr	BPTF_2	chr17_67825365_C_T,chr17_67911547_C_G	0.01437455334956587,0.027807620738219758	2.5754103071800682e-05,0.006958200054189394
egfr	UGGT2_3	chr13_95833163_A_G,chr13_95853698_T_C,chr13_95860933_T_C	0.015116310313098947,0.037400522782126695,0.007496186466991611	0.000224596103770692,0.0011686091908779301,0.002068524896740717
egfr	FNDC3B_3	chr3_172362611_AT_A,chr3_172328905_GT_G,chr3_172286041_CTTTT_C	0.015509630370521969,0.002266663581871069,0.0003779941256659541	0.0007669696976411361,1.7757436099968484e-05,0.031871180713847265
egfr	CLIP1_3	chr12_122328152_A_C,chr12_122328157_C_T,chr12_122328162_C_T	0.01554438347868009,0.004768276278894758,0.002667521200669866	0.002481037749459045,0.041472618812521435,0.048511002649469816
egfr	TNKS_6	chr8_9680125_G_A,chr8_9720284_A_AT,chr8_9720294_C_A,chr8_9735571_A_C,chr8_9751720_A_C,chr8_9766458_A_C	0.015553063070783985,0.021640953132470588,0.009525586921605824,0.006640140033620625,0.006977786341777385,0.032727629530903864	1.1196019412041484e-09,6.428366457977679e-07,9.234432766615335e-08,4.809045747636942e-06,0.019396751254115357,9.650265166072016e-07
egfr	NAA15_2	chr4_139349721_G_A,chr4_139349435_AT_A	0.01573160679440035,0.003429044586968857	0.0002098904518747522,0.002911064627846368
egfr	RANBP3_5	chr19_5928023_T_G,chr19_5928174_T_C,chr19_5915583_A_G,chr19_5925847_A_C,chr19_5978199_C_T	0.01583040778996785,4.474815722770587e-05,5.7769976083466666e-05,0.0026896515436457035,0.007526230369901563	0.009045897483820205,0.0004179910655369823,0.03657225828634877,0.013386174688145538,0.043887995871297616
egfr	CCP110_6	chr16_19536035_A_G,chr16_19536181_C_T,chr16_19545945_C_T,chr16_19541861_T_C,chr16_19536052_C_A,chr16_19548016_T_G	0.016159655378318708,0.04502177918333454,0.008022125809200288,4.851993209582035e-06,0.0004153878057481152,0.025513237898367132	0.00016378049017362915,0.0005567133937571787,0.0006179187799490345,0.015929257083152543,0.0007996357401027085,0.009536820248258198
egfr	ANXA11_2	chr10_80166029_C_T,chr10_80161797_T_C	0.016605419991514502,0.0051164435438795204	0.007800123858178394,0.0013053025194313356
egfr	PLEC_5	chr8_143935900_T_G,chr8_143916360_A_G,chr8_143918739_A_C,chr8_143929244_A_C,chr8_143934289_T_G	0.01665471808934805,0.0034243187807631525,0.0018067465091272969,0.0008521926558447601,0.0001319263889148404	0.0004960012901022363,0.00910116635228719,2.138708286444241e-05,0.04249632659180479,0.008202162742211878
egfr	PDHB_5	chr3_58429863_C_A,chr3_58427942_G_T,chr3_58430808_C_T,chr3_58431043_T_TTTA,chr3_58431689_C_T	0.016694590509161198,0.0034915452482365546,0.0014468501934601355,0.00012132584593612988,0.0014468501934601355	1.9636106867401007e-06,9.607912469556515e-06,1.1215690852590127e-06,4.480434017438887e-06,1.1215690852590127e-06
egfr	ABHD12_3	chr20_25307869_C_T,chr20_25297964_G_A,chr20_25301097_T_C	0.017594886478281925,0.043687457267011516,0.004129132243776882	8.56668297363822e-06,0.00227969505884927,0.0004270759204191932
egfr	TRAPPC8_10	chr18_31858057_A_C,chr18_31913653_A_G,chr18_31900873_G_A,chr18_31900876_C_A,chr18_31867505_T_G,chr18_31907633_T_A,chr18_31846589_A_C,chr18_31871211_T_A,chr18_31901115_GT_G,chr18_31858058_CT_C	0.01811627325789324,0.0017149077087971164,0.007882909715425471,0.0003097530865800165,0.0017696529343949547,0.003408008625421304,0.0025767772792916893,0.020052128513604172,0.0014872998913138286,0.009626844127190594	0.006180390175955454,0.009898646981541573,3.5402082656175115e-05,2.004341589623153e-05,0.00036773660587014015,0.0008596942505949141,0.0019258630221215085,0.0005317253240119541,0.03754796616685669,0.003048367023556882
egfr	NARF_2	chr17_82488071_A_G,chr17_82485433_G_A	0.018611831902577654,0.0032741374426950077	0.0015678226483248074,0.03776328708562675
egfr	RPL9_3	chr4_39454772_G_A,chr4_39458104_T_C,chr4_39457622_A_G	0.01872028096022281,0.038040018913816906,0.013766563241610607	0.004161577416808298,0.004570198384291764,4.793806278603332e-07
egfr	SENP7_2	chr3_101347873_T_A,chr3_101513249_C_A	0.01892010828896953,0.027162288974149237	4.432034386075619e-05,0.00843965290168897
egfr	HERC1_4	chr15_63666001_A_C,chr15_63666004_T_C,chr15_63754569_A_C,chr15_63706823_T_C	0.018947416114520832,0.012801946597404643,0.009094911651776984,0.0001905333488051304	0.0009552551098417773,0.0050390069990103115,0.007343118479360836,0.005050957906342418
egfr	DOCK11_2	chrX_118627539_A_C,chrX_118580020_T_G	0.019238892996198773,0.002446966159681028	0.00012436903410890539,0.02379391735060052
egfr	KLF5_3	chr13_73063987_G_T,chr13_73062772_A_AGTGT,chr13_73063986_TG_T	0.019354403860496208,0.037567154465037694,0.006314572274949971	0.008502737493358522,0.0008455054702052634,0.045197394376435635
egfr	FERMT1_2	chr20_6119441_A_G,chr20_6076305_T_G	0.01953104506649206,1.5328575507414378e-05	0.003951008923557318,0.005589077504505465
egfr	CGGBP1_2	chr3_88056114_A_C,chr3_88058700_T_G	0.019690640293771062,0.0001488078729312028	0.0013325718879930134,7.124415972693971e-06
egfr	CEP85L_4	chr6_118511157_T_C,chr6_118565452_T_C,chr6_118565798_G_T,chr6_118652790_A_G	0.019951442705337254,3.4006295145334306e-05,0.006640489210238536,0.005690521125333515	0.0019936945989450267,0.031500707148776626,0.011376444437361329,0.01248838915032558
egfr	TCF4_7	chr18_55585157_G_A,chr18_55464257_C_A,chr18_55463971_TGTGTGTGA_T,chr18_55275657_A_G,chr18_55403517_A_C,chr18_55461237_G_T,chr18_55234488_T_G	0.02005132938992895,9.139603483849228e-07,0.003907248287482544,0.04979553061082194,0.027277557605803925,0.004036463102105114,0.0005592100190603741	0.002362550141751555,0.032420073593804284,0.03333184670009802,0.0013930308437610063,1.5397131093463103e-06,0.04572000946513434,0.005926553123167896
egfr	DQX1_2	chr2_74518953_C_T,chr2_74519195_A_T	0.02016550460713128,0.02345411840768387	0.001543466936969916,0.0012259823356569838
egfr	UBR5_3	chr8_102327653_A_C,chr8_102288240_T_C,chr8_102311353_A_G	0.02158342295983112,0.000182245886028422,0.002891650419980013	0.0014448817758050778,0.041616237854309936,0.00926532742682097
egfr	UBR7_2	chr14_93227076_C_T,chr14_93227060_C_A	0.021764228343538142,0.00036547494521639036	5.580051554471299e-12,0.004489348973894868
egfr	PRDM15_6	chr21_41804523_A_G,chr21_41857170_C_CT,chr21_41878737_C_T,chr21_41878845_C_CG,chr21_41879218_C_A,chr21_41860296_C_G	0.022209828018085867,0.0016831430872538335,0.001963497325920565,4.181886700329235e-07,0.0008539747138144563,0.003762939149636617	0.0024789131706555692,0.04559041805735448,0.004333100546220035,0.0014981405701937028,0.007033127481264185,0.003918924565748825
egfr	HPS4_3	chr22_26464303_G_C,chr22_26466187_C_A,chr22_26466246_T_C	0.023338960947810374,0.0034082024391394804,0.008599880725164986	0.00049975228288003,0.013660798942983977,0.013660798942983977
egfr	KIF13A_2	chr6_17759921_G_T,chr6_17779691_GA_G	0.02351576585497226,0.0016700241845674759	0.005082432403932738,0.03874282920193672
egfr	SLC35B4_8	chr7_134294793_A_T,chr7_134294800_C_T,chr7_134294826_A_G,chr7_134295043_T_C,chr7_134296475_G_A,chr7_134299375_A_G,chr7_134300126_G_A,chr7_134304791_A_G	0.02373113198705864,0.01698627709999008,0.006372984518535906,0.02196618128109366,0.0003440877501955943,0.006567115319239084,3.4006295145334306e-05,0.005046500727253695	0.007700956159853255,0.0033988992551489622,0.003846947305778054,0.003846947305778054,0.0005322435434420271,0.004732359355015072,0.00026123770283039777,0.0007109966209961128
egfr	L3MBTL2_6	chr22_41213686_C_T,chr22_41221314_G_C,chr22_41217184_C_T,chr22_41217299_C_T,chr22_41221156_T_TG,chr22_41214238_A_G	0.02384699817673188,0.036506965435244586,0.00046243520821700383,0.0014542660494230402,0.0048712846790899276,0.009223190722677185	0.0010787186334203051,0.0001832674707524145,0.0038205423576211455,0.004209694792725524,4.2157738222413464e-06,0.04965109007915304
egfr	RAI14_6	chr5_34810866_G_A,chr5_34811689_T_C,chr5_34812303_A_G,chr5_34812384_A_G,chr5_34814795_A_G,chr5_34826376_A_C	0.02398248389974741,0.003021738485801497,0.03016889098915158,0.04699754955019005,0.007276272312251042,0.03015590631046501	0.005930385895234786,0.02067007422009637,0.008963944637711066,0.0075054618188784596,0.002646842318515723,0.006485048570616563
egfr	ARHGEF10L_2	chr1_17632421_T_G,chr1_17581112_C_T	0.02441616386812752,0.008405600723765323	0.00740919250255517,0.019746113249432044
egfr	WFS1_2	chr4_6300580_T_G,chr4_6301666_T_G	0.024665242803626187,0.008957131401361508	0.0005139212842413073,0.005931412638336574
egfr	TPP2_5	chr13_102645085_CT_C,chr13_102649187_G_T,chr13_102629949_C_G,chr13_102634223_C_T,chr13_102645085_CTT_C	0.024741402723073853,0.028415295283801194,0.001061432461116305,0.03296472481201721,0.00032041277623460525	0.0017617933204615989,0.0003388682906380855,2.491492385425685e-05,0.0010859815068279958,0.04128722708381896
egfr	DPY19L3_3	chr19_32480317_C_T,chr19_32482171_C_T,chr19_32457979_A_AT	0.02575962131883935,0.041529928834727996,8.068330723796263e-08	0.00488668851811109,0.00656763144792808,0.0003669711749463792
egfr	SYNE1_13	chr6_152149487_A_G,chr6_152310394_A_C,chr6_152302141_A_G,chr6_152350340_A_C,chr6_152350418_A_G,chr6_152350784_G_GA,chr6_152350840_A_G,chr6_152354719_A_G,chr6_152373049_T_C,chr6_152416413_T_G,chr6_152352408_C_CT,chr6_152326359_G_A,chr6_152167902_T_G	0.02589202251594358,0.0068225672761204,0.018111885168250186,0.001534088782688901,0.00015349542079229654,0.003947934300958396,0.009039115199453142,0.0032281218393380826,0.034085027891066176,0.0074217808535962425,0.0003084243419514754,0.04013949097321684,0.007925318609942202	0.0022312687521415984,0.000300569048618415,0.000916091757381376,0.04334315784101184,0.025133645776259043,0.015037738599618973,0.049886685026608805,0.04777964311542563,0.003302156741579197,0.012499408296212235,0.002950466518563949,0.002843434249435789,0.025194372743123864
egfr	BAIAP2L1_2	chr7_98312162_T_G,chr7_98310492_T_G	0.02645273506751201,0.017881464475754172	0.002108350377110309,3.1631490207583316e-05
egfr	CXXC1_4	chr18_50283881_C_G,chr18_50283981_A_G,chr18_50282775_A_C,chr18_50285505_A_G	0.02700492420991353,0.00030830634455756233,0.00020363998830215009,0.024668590953954232	0.0054045514118498715,0.0069760254674185035,0.00041677651706905364,1.2396826716404366e-06
egfr	ITGB5_3	chr3_124769064_T_G,chr3_124796789_C_T,chr3_124809087_T_G	0.027271474201973192,0.0030628908663900517,0.02459057498205289	0.0006588536356118503,0.03655295537599197,5.4585187494895796e-05
egfr	BRD4_2	chr19_15255220_T_G,chr19_15264730_T_G	0.02738257500091704,0.0024688743871748233	0.003128882089479218,0.012931811845921107
egfr	TUBGCP6_3	chr22_50218683_C_T,chr22_50226183_A_G,chr22_50216669_A_G	0.02873848846989375,1.7193787546395546e-05,0.001425645880342349	0.0032493001194240914,0.004608803965780261,0.0053976890998902035
egfr	SH2D4A_2	chr8_19373444_G_GTA,chr8_19373444_G_A	0.029078590360841292,0.0012205889084294006	0.0029847738366696104,0.03439931765423256
egfr	UPP1_3	chr7_48088999_G_A,chr7_48108129_C_G,chr7_48108147_T_G	0.029144965782620207,0.015833254501378846,0.01682115524692246	0.0003765748447247093,0.0002337913556195707,0.0015081620173450355
egfr	WDR48_5	chr3_39068755_C_T,chr3_39069649_C_A,chr3_39066494_T_A,chr3_39077046_G_A,chr3_39052175_T_A	0.030420442989910295,0.044145461001922535,5.492585713676155e-05,0.00014207366024108895,0.015418219237359813	0.00013091692663621323,1.1291180538837308e-09,0.030704581537927867,0.04365312343408456,0.002516254064872987
egfr	PDS5B_5	chr13_32741072_A_T,chr13_32758091_C_T,chr13_32675925_C_A,chr13_32710010_G_T,chr13_32652145_GT_G	0.030726392282429425,0.00123879071402958,0.0006856670147522433,0.002121608222392312,0.0007921211551638221	0.001639201016530517,0.0023301391981286807,0.004241708828197667,0.017388913859398773,0.002787725341881676
egfr	AHNAK2_13	chr14_104948863_G_C,chr14_104950348_C_G,chr14_104952007_T_G,chr14_104952054_C_T,chr14_104954590_A_G,chr14_104955559_A_C,chr14_104949306_T_C,chr14_104950948_C_T,chr14_104946565_A_C,chr14_104949318_G_C,chr14_104953856_A_C,chr14_104944923_A_G,chr14_104945888_T_G	0.0308328381135858,0.016748316074642184,0.03839823545317707,0.03874915731384604,0.0072096008154851265,1.5768275144985015e-05,0.006402387188591212,0.006209224175079767,0.02197650841839336,0.005813098445302893,0.024214266407806717,0.0185888935199706,0.0006623043768660483	0.0037872773041585602,0.0010008042001551844,4.242877237542688e-05,4.758634079373864e-05,0.044213954062984784,0.00506490504122054,0.005256944789299486,0.009057439080581924,0.006657596405885244,0.015474300784924832,0.003500316527332319,0.004782218518041667,0.009471254952683202
egfr	PSIP1_4	chr9_15469426_TA_T,chr9_15472613_GA_G,chr9_15478664_T_C,chr9_15473904_C_CA	0.03090002089985741,0.010885733995064931,0.0036412739882121493,0.019522544533840024	0.0021167351616768765,0.002781333210996778,0.04454350703768868,0.047598542315053116
egfr	ANK3_2	chr10_60140286_C_G,chr10_60140292_G_T	0.031415751059474716,0.004915637551152243	0.006334167714527676,0.025015110862319518
egfr	PLEK_3	chr2_68380987_A_C,chr2_68388306_A_G,chr2_68380161_C_G	0.0317726416239668,0.008640427676032429,0.003025481684231003	0.0018651167043750433,0.012112306050675708,0.004442991541746456
egfr	HMGB1_2	chr13_30463652_C_G,chr13_30465849_T_C	0.03226480417721332,0.0001648093940653516	0.0005823170484383475,1.5385023502599213e-07
egfr	ACTN1_2	chr14_68890121_A_G,chr14_68904620_A_G	0.032894585296185316,0.002540635063275344	0.0030504600602986385,0.01924890787722053
egfr	FAM193A_2	chr4_2662705_A_G,chr4_2659865_A_C	0.033419216681695084,0.04113816735227994	0.006119225115333783,0.002421422710409682
egfr	ALS2CL_3	chr3_46688267_C_G,chr3_46671861_C_A,chr3_46683906_C_A	0.03379224538431711,2.315014453759593e-05,0.005940717099935289	0.0010458636942191153,0.016517080453509674,0.048512125386189216
egfr	SMARCA5_3	chr4_143521582_C_T,chr4_143514027_G_A,chr4_143513907_T_G	0.03389913212461259,0.0005336701932334038,0.00047650766195259835	0.009752627346239709,0.0006586181076668231,0.004556295949163353
egfr	TMBIM1_4	chr2_218278506_G_A,chr2_218278604_T_C,chr2_218279426_G_A,chr2_218282145_T_C	0.03396031249525595,0.02844679337110864,0.0068961961974542295,0.0018492744109954121	0.002273449490648745,0.0012042001777173455,0.0022480783740468167,0.030530266212098117
egfr	ZNF236_5	chr18_76959812_T_C,chr18_76968158_T_C,chr18_76968252_C_T,chr18_76936580_G_T,chr18_76968514_A_G	0.034863364756142684,0.00544264119615534,0.007385442293655849,1.258127500782992e-05,0.001396157570840323	0.004671655781344212,3.359123080186937e-06,3.816383122507129e-05,2.2508576141383803e-05,0.00014020410621502926
egfr	DMAP1_3	chr1_44213884_A_G,chr1_44219323_T_C,chr1_44214487_A_C	0.03508585380179657,0.0001543183975019544,0.000996146741984629	2.797176359518221e-05,0.04898236049763705,0.041077293102317024
egfr	GIT2_2	chr12_109951210_A_C,chr12_109952676_A_C	0.038020170939281527,0.044654978525331915	0.0015711134341594402,0.0073535263645836966
egfr	PBRM1_4	chr3_52642049_CA_C,chr3_52642048_AC_A,chr3_52642050_A_T,chr3_52658412_CTT_C	0.03826328245790342,0.003417708183485354,0.003417708183485354,0.004371631368875628	0.0014123627803440367,0.00010786476378721626,0.00010786476378721626,0.04797045127180218
egfr	SEMA4B_3	chr15_90230550_C_T,chr15_90219735_T_G,chr15_90223369_T_C	0.0382907038385724,0.00014017436078508742,0.003606528003523896	0.003576989974401659,0.0196110620734337,0.012423711849739305
egfr	CDH1_2	chr16_68823310_T_G,chr16_68810107_C_G	0.03866739925480673,2.3568872507011226e-05	0.0025541666878341144,0.0045199561560194616
egfr	PAK4_3	chr19_39176740_T_C,chr19_39178411_T_C,chr19_39178960_A_ATG	0.03964657176847531,0.0031968419187330646,0.00031366512220605466	0.0005253339462112416,0.012050619287225093,0.04112372072532399
egfr	KDM5A_2	chr12_310904_G_A,chr12_323658_C_A	0.040083104628847975,0.03485434053230182	8.99232571405919e-08,4.775460326696479e-06
egfr	CHMP7_4	chr8_23249152_A_G,chr8_23260130_T_C,chr8_23260642_T_C,chr8_23255149_C_T	0.040858161657175214,0.0021955959993491484,0.001347026932454516,0.005979199546716722	0.00985156252549634,0.007951126415472621,0.005852678740537498,2.528028640474925e-05
egfr	FASTKD1_2	chr2_169557305_CA_C,chr2_169557305_CAA_C	0.04142328785089491,0.016746895905411573	0.00016945881737810868,0.003864236188058555
egfr	MRPL39_5	chr21_25587877_T_G,chr21_25588774_T_C,chr21_25594005_A_G,chr21_25603938_A_G,chr21_25607316_G_A	0.04194490101459973,0.01937493996228174,0.01845646940649424,0.02800309093409305,0.00630118834188515	5.7418126731545284e-08,3.6929628125728576e-08,2.5701269842959545e-08,1.0577675519010665e-08,3.688861166466308e-08
egfr	PON2_2	chr7_95406313_A_C,chr7_95406317_T_C	0.04295809677939748,0.03518057074232925	9.367508145310504e-06,9.041805671182428e-07
egfr	ATP9A_2	chr20_51608625_A_C,chr20_51627544_T_G	0.0453107586125816,0.0033064577154371753	0.0016205979394364285,0.046011362965187
egfr	SYNE2_3	chr14_64189964_AT_A,chr14_64022731_CT_C,chr14_64122119_G_A	0.04554515566635235,0.0259958042872378,0.005029743152006167	6.34029580306576e-05,0.003556496243260812,0.031891035954103614
egfr	EXD2_2	chr14_69236592_C_T,chr14_69236597_G_T	0.045815872520569866,0.007261223228798206	0.006743325380355538,0.009984452523516405
egfr	USP22_9	chr17_21002832_G_C,chr17_21002938_C_T,chr17_21002944_A_G,chr17_21005012_T_C,chr17_21018179_C_T,chr17_21021210_G_A,chr17_21021307_T_C,chr17_21028347_G_T,chr17_21043080_T_C	0.04602479247359704,0.008276359973551,0.0003145539245206166,0.00013159988064048868,0.00017641068386537028,0.00018037842009303046,0.002766843921558569,0.00965100020152009,0.0021915580128042123	5.2405530742318296e-05,0.0001522332352001979,0.0010200867803667195,0.0002608036035294038,0.0002258154609608441,0.00012857609143244398,4.777859944106238e-06,0.001140393407840919,0.01642994041963463
egfr	R3HDM1_2	chr2_135621624_GT_G,chr2_135661361_A_C	0.04643229751040803,0.01096218490346052	0.007933574405897037,0.00075038338644858
egfr	LAIR1_2	chr19_54364274_T_C,chr19_54364717_T_C	0.04672350230262375,0.015465209925053043	0.008257714587898193,0.006617848488520711
egfr	EVL_5	chr14_100126634_T_G,chr14_100132827_G_A,chr14_100126622_G_A,chr14_100132645_T_G,chr14_100135917_A_C	0.047372429474904484,0.0016660544745078804,0.004134369004838065,0.00016640135361204822,0.0031029134247096963	4.756430435799507e-06,0.00563219201718044,0.01997007957497231,0.026704266687616097,0.006469582595095918
egfr	RNF123_2	chr3_49714152_C_T,chr3_49700145_G_T	0.047756940070976237,1.1366734297895966e-06	0.00816572334990732,0.0037608177292696564
egfr	DNMT1_2	chr19_10162649_G_A,chr19_10143809_G_C	0.04804143143713783,0.022663915935835485	0.0013474327860987167,0.0054179883970128856
egfr	BTBD16_4	chr10_122275013_G_T,chr10_122275188_T_C,chr10_122285973_C_T,chr10_122291060_G_A	0.04876523124872777,0.04476796806488366,0.00874169822078938,0.03049550442980961	0.0003520007001970831,0.00020893956494733148,0.0013169765604353282,0.0026073441109972398
egfr	FUCA2_2	chr6_143504166_C_A,chr6_143507227_A_G	0.049200639651661375,0.029895339238934462	0.00639339868461808,0.0054745403112583324
egfr	PPIP5K2_3	chr5_103201499_T_G,chr5_103201584_A_G,chr5_103201656_T_C	0.04957254295359858,0.00015517194478671765,9.016600091479696e-05	0.00015030812167049831,0.020151832289907558,0.029631285544831236
egfr	TIMM44_3	chr19_7932571_A_G,chr19_7932574_T_G,chr19_7932577_T_G	1.3167297251695571e-05,0.0003422957438462025,0.0005904858316322034	0.02845639919448445,0.006688970144575634,0.006057634937627619
egfr	MEX3C_2	chr18_51196847_C_T,chr18_51196775_CGCCGCCGCG_C	1.329885109524148e-10,0.0022225090338153708	5.249784413332885e-07,0.01963887463995091
egfr	MTUS1_3	chr8_17754377_G_A,chr8_17755366_A_G,chr8_17721812_A_C	1.3576985363683765e-05,1.972258766974004e-08,0.02629101974751153	0.001701316781434502,0.026616233857667596,0.002181030051469235
egfr	CTSH_2	chr15_78922969_A_C,chr15_78939184_A_AG	1.4037598311677378e-05,0.0001924278188105154	0.010345021977573308,0.0344244477250216
egfr	IL18_3	chr11_112150193_T_G,chr11_112155193_G_C,chr11_112155192_T_C	1.461260124702572e-05,7.96641505141555e-07,0.03134154150698633	0.012472744364369587,0.011978242096605442,0.007248539214372238
egfr	ZNF654_2	chr3_88139270_G_A,chr3_88140191_T_C	1.4751691487034687e-06,2.0819038805248358e-07	0.0018019171147236148,0.0019048877551503765
egfr	ZNF589_6	chr3_48241161_TGCGC_T,chr3_48241205_A_G,chr3_48257949_T_C,chr3_48268338_C_G,chr3_48286239_T_C,chr3_48286261_G_A	1.6889590876869102e-06,1.1715920482680521e-06,7.920379942105592e-05,2.8491798121821795e-05,1.5027613326502343e-05,7.796162715352446e-06	0.0007986098597650371,0.0010457901523321454,4.006095509659407e-05,0.0020191705610664206,0.001627877596998014,0.0011919391649323414
egfr	EPS15_6	chr1_51361249_T_C,chr1_51405766_G_GACTC,chr1_51440277_CTGTG_C,chr1_51463832_TA_T,chr1_51472751_T_G,chr1_51461237_G_A	1.6925862398730225e-06,4.1443509369940415e-05,0.031894015484001656,3.0950467922083264e-06,0.02951071302033457,0.01032478965873057	0.0002615744055786565,0.0005725418098281438,0.00017362501014406024,0.0002615744055786565,0.0045422702652321255,0.0029577065864897127
egfr	ZNF266_2	chr19_9413509_A_G,chr19_9420011_TG_T	1.7177250175637761e-06,0.04040969628183889	2.6110373221371133e-14,0.004948136499581445
egfr	BCAM_2	chr19_44820881_G_A,chr19_44811510_C_T	1.7938533698319987e-05,0.0006276370995178965	0.006588412083819078,0.021875016141096045
egfr	C3orf38_3	chr3_88150029_T_C,chr3_88150035_T_TC,chr3_88150148_T_C	1.7996666116084316e-06,0.00014178936922186315,2.595905755446793e-06	6.57647003118834e-05,4.649030455483649e-05,7.105213671060247e-05
egfr	ERICH1_8	chr8_659132_C_G,chr8_657766_C_G,chr8_658018_C_T,chr8_666590_T_A,chr8_673593_G_A,chr8_715858_C_T,chr8_659879_A_C,chr8_659039_G_A	1.8121573621263876e-05,0.0010420319235614432,0.04660176454698252,0.004834244365989843,0.007260620745344446,0.04859602375702362,0.0025352106440479803,0.002455544576447661	0.0054140514901705895,0.043640948824396286,0.0013028832620993098,0.018154111038570942,0.01865482112843118,0.00034437810537597347,0.0461414202945825,0.014420687330437538
egfr	LSR_2	chr19_35267372_G_GGGA,chr19_35267177_A_C	1.823380047726112e-06,0.03651632235421607	0.0021105674130373147,0.0028831204631532326
egfr	PIK3C3_3	chr18_41955191_C_G,chr18_41955194_A_G,chr18_42043978_A_G	1.9440372522869497e-06,0.0006320335833085862,0.023735103370508225	1.065744821934887e-06,0.0001342557450694381,0.00031280032152652704
egfr	TAF3_4	chr10_7824594_T_C,chr10_8013652_G_C,chr10_8013913_G_A,chr10_8014532_C_T	2.0664435570944493e-05,0.004655883072306037,0.00943383216960874,0.0009463104379838767	0.03748233778862958,0.008249411816346357,0.004857051949006447,0.0014732747867095904
egfr	FNBP1_2	chr9_129909080_T_TG,chr9_129923982_A_G	2.1184979283245958e-05,5.268485267589101e-05	0.013989753243576588,0.019443664939858312
egfr	SACM1L_14	chr3_45719623_G_C,chr3_45722143_A_G,chr3_45722754_A_G,chr3_45723052_T_C,chr3_45731250_T_C,chr3_45731280_G_A,chr3_45732240_G_A,chr3_45737644_A_T,chr3_45705344_A_G,chr3_45706937_G_A,chr3_45713257_G_A,chr3_45712995_C_A,chr3_45689454_T_G,chr3_45739488_A_G	2.2026676208492585e-06,9.443816831049491e-07,0.0022018800476893614,3.5837125763699036e-08,4.4397997289151143e-07,1.2227532248856571e-06,1.3468374724431254e-06,7.150800554712763e-07,0.013551678428059705,0.0062092789567569535,0.0035804098855498063,0.005851841559996625,0.0028202119918153247,0.030877901512994674	2.7990310927885382e-05,2.6591646486392756e-05,0.006779520290921261,3.962907852818685e-05,1.1237814806460453e-05,4.359294069545172e-05,5.1558332133000766e-05,3.496973226569382e-05,0.0006684767742569695,7.302437009455565e-05,9.003284436221187e-05,0.005848457401461229,0.03994336344384322,5.7399601602553275e-06
egfr	TXNL1_3	chr18_56602813_A_T,chr18_56626612_C_T,chr18_56651278_A_T	2.210469276189849e-06,0.022001595468935316,0.02149358538709261	4.0417773765221675e-09,2.767068005468822e-10,1.7102012334179478e-05
egfr	PTPN3_2	chr9_109436866_A_G,chr9_109406452_T_G	2.248398882883789e-05,0.008436388558613016	0.022560149794550868,0.025748841495573487
egfr	LAMA3_9	chr18_23861753_C_T,chr18_23915519_T_C,chr18_23946123_C_T,chr18_23949758_G_A,chr18_23954737_C_A,chr18_23954739_C_T,chr18_23939340_A_C,chr18_23713905_CT_C,chr18_23846109_T_G	2.2546401848550504e-07,0.0006963202810397933,1.582829210028338e-05,1.6534066895813288e-06,2.6769400746243374e-05,1.9933398900670928e-05,0.0008881294144847822,3.0126882423530804e-05,3.5426816292959363e-05	0.033914720695717084,0.013114315448110179,0.03066224880164858,0.025703076793439833,0.042551605063568684,0.030472466536971138,0.013225085724631118,0.01613050085470659,0.04009682047166014
egfr	MTMR9_3	chr8_11284836_T_G,chr8_11309724_G_A,chr8_11322815_A_C	2.349458678158868e-06,0.0004653758499732343,0.008022838484344897	2.4088220462781546e-11,0.0074905636429132404,0.008917788804222488
egfr	ITGA6_4	chr2_172427981_A_G,chr2_172427985_C_T,chr2_172484735_A_G,chr2_172490965_G_T	2.55642040821661e-05,1.1751587238624405e-05,0.002854965230943433,0.025550057038402886	0.021886276374067117,0.023752544661456654,5.351259734935356e-06,0.007174810273459709
egfr	KRI1_8	chr19_10557707_T_C,chr19_10558277_G_A,chr19_10560316_C_T,chr19_10565667_A_T,chr19_10565747_G_A,chr19_10561817_C_T,chr19_10562664_C_T,chr19_10565811_G_GCC	2.6474598014609052e-05,9.523794655306364e-05,0.00011786607794266038,0.0001616270444439651,3.4012624242046115e-05,1.477271100442178e-06,1.0798436673597302e-06,6.316959826240111e-06	0.00012897741560140272,3.792910022705542e-05,2.0569928046658807e-05,2.711645177509063e-07,3.211054485740389e-07,1.8153836897508705e-05,0.0002329401807770252,0.0008450486067550477
egfr	GBP3_2	chr1_89007941_G_A,chr1_89011034_A_T	2.713567196210831e-05,0.047917709012617486	1.221534419837023e-06,2.259902209453749e-08
egfr	FGFR2_2	chr10_121487530_T_C,chr10_121520352_C_T	2.796050535454376e-05,9.346629403777272e-05	0.015364585786772819,0.004955596968571121
egfr	TNRC6C_2	chr17_78049826_A_C,chr17_78067796_A_G	2.865420177578161e-05,0.003859622145256892	0.03771979541922566,0.03295200627528048
egfr	PDGFRB_2	chr5_150135511_G_A,chr5_150129967_A_C	2.9565587793102473e-05,0.0011142332419287124	0.007951396082365123,0.010884978116376998
egfr	ASPH_2	chr8_61578734_T_G,chr8_61638365_TA_T	3.0349566769525607e-06,0.014784455717628972	0.00027481062695969863,0.0033421074285719613
egfr	MRPS25_2	chr3_15065217_A_C,chr3_15065038_A_C	3.231333497421803e-05,0.03913000849637771	0.0017607662142123156,0.008302391831822605
egfr	CNIH4_2	chr1_224356827_A_G,chr1_224379302_G_A	3.345540294148141e-05,1.3298114540105321e-05	8.270232693194595e-06,0.004957072960670954
egfr	STAT5B_2	chr17_42212246_T_A,chr17_42218217_T_TG	3.457612678303974e-05,0.009108698459398929	0.049805612849012526,0.041598649064757576
egfr	NRF1_5	chr7_129690176_C_G,chr7_129709261_G_A,chr7_129710330_A_C,chr7_129711604_C_G,chr7_129717099_T_G	3.514964941916984e-05,0.0012574856804500286,0.0029569614211133396,0.0009106050710647207,0.0008333980926761285	0.0008588680251565,0.0020358531276104324,0.001863531871592876,0.00048643171799331433,0.006420212881434713
egfr	C21orf58_2	chr21_46302477_A_G,chr21_46322980_A_AG	3.600317129022087e-06,0.000178616399448272	0.028316032350682373,0.0464048927112107
egfr	EBF1_2	chr5_159099526_TA_T,chr5_159099526_T_TA	3.7020844162640586e-06,0.0061991425888554795	6.309766911659592e-06,0.009920112112628023
egfr	PCNT_10	chr21_46438359_T_C,chr21_46440304_C_T,chr21_46442711_A_G,chr21_46444647_CTTT_C,chr21_46444900_C_T,chr21_46444910_G_C,chr21_46355631_G_C,chr21_46425893_A_C,chr21_46444675_T_G,chr21_46444677_T_G	3.8924131898677556e-05,0.00010294155569212726,0.00442543345514155,0.0007255960816556072,2.666879695038341e-05,2.666879695038341e-05,0.045239341586552524,0.0052653795831940926,0.011583428163992472,0.0012373038631552345	0.0007850146452497258,0.0011784720417395535,0.0010237263069919882,0.01824823490083048,0.00036147873774628185,0.00036147873774628185,0.0004512031541319047,0.01998375792506145,0.009046665740785187,0.01284951528238673
egfr	RFT1_3	chr3_53104238_T_C,chr3_53120116_ATTAACTGCAC_A,chr3_53120127_T_G	4.1039519054300644e-05,0.010916191776172972,0.0009241739865608092	0.019143884189355254,0.0012736601162827682,0.0003755806923286365
egfr	NGLY1_4	chr3_25733865_A_C,chr3_25736073_G_T,chr3_25764388_T_C,chr3_25732334_A_C	4.193690016854428e-05,1.0629890346566115e-06,0.00018111373229034528,0.000337635257557846	0.004048589804059987,0.0001003348545752524,0.008193558074218642,0.0008517116761761035
egfr	SHPRH_2	chr6_145955343_T_G,chr6_145922945_GT_G	4.197525341776357e-06,0.02497921302813516	0.0019437040989644704,0.0032085441168495693
egfr	PSAP_4	chr10_71817510_G_A,chr10_71820222_G_A,chr10_71823763_G_C,chr10_71825769_A_G	4.253559292570684e-05,1.4584188008395623e-05,0.0007450217858733059,7.15024619363838e-07	0.005989723973244358,0.004815444492138627,0.005093191498317171,0.001137729147313085
egfr	EPG5_4	chr18_45907942_A_G,chr18_45860332_T_G,chr18_45967161_TG_T,chr18_45949582_G_A	4.41056482155363e-05,0.0325761410753079,5.0265150457437094e-08,0.0009686733993730644	0.00018099150138285703,5.454441871402812e-06,0.0031405068156816515,0.04928013785599337
egfr	GRB7_2	chr17_39746744_A_C,chr17_39737973_T_C	4.445333626793725e-06,3.7814817628535414e-05	0.015646545098240962,0.0275943135807812
egfr	TBC1D5_5	chr3_17233681_G_C,chr3_17238034_T_C,chr3_17258641_A_C,chr3_17428395_ATG_A,chr3_17238102_T_G	4.500069192335354e-07,5.287266410953234e-06,1.0934340959097885e-06,0.00038136339583758066,0.0015374412890621536	0.034850654424783314,0.048246561657752436,0.034850654424783314,9.180133184684152e-05,0.00428366923460265
egfr	TTLL3_5	chr3_9825941_C_T,chr3_9826893_A_G,chr3_9829346_T_G,chr3_9832986_G_A,chr3_9835303_G_A	4.506908857236149e-08,9.62440960091469e-07,6.721794266994746e-08,3.966565971028462e-07,0.047234941799100816	0.004512931116648239,0.009182452462015591,0.0016666988915567758,0.005845443747610279,0.00549007437147901
egfr	HAUS1_4	chr18_46118343_C_T,chr18_46123257_C_G,chr18_46122767_C_T,chr18_46118217_A_T	4.791384820535998e-09,9.485176947904584e-06,0.0008672645013724843,0.00028116915718734436	0.0017369506644946814,0.009435638863427392,0.00147832294217736,0.0031860563996751264
egfr	FGD4_3	chr12_32640343_A_C,chr12_32640545_A_C,chr12_32582270_A_C	4.811506604588182e-07,0.027930843946287982,0.032681639982183666	0.0008756223675282764,0.0092856233481216,0.0015384650399147507
egfr	PPDPF_2	chr20_63522320_T_G,chr20_63521771_A_C	5.287951236043515e-05,0.00689972604034751	0.043695255169413805,0.0005655672033991309
egfr	ITGA2_2	chr5_53091493_C_T,chr5_53042183_A_C	5.4531358390517686e-05,0.03919199794742103	0.043791975990725485,0.0012604443318972665
egfr	SLC44A3_5	chr1_94839884_A_G,chr1_94865029_A_C,chr1_94857210_T_G,chr1_94857357_C_G,chr1_94892383_G_T	5.602338522082008e-05,0.046411065532556,0.007150508797521116,0.017457449518246654,0.009632517735858792	0.038972716080465035,0.008550555716824466,0.016460335501241437,0.008036938687219244,0.029740691948763408
egfr	USP4_5	chr3_49284594_T_A,chr3_49305742_G_A,chr3_49324936_C_T,chr3_49335612_A_G,chr3_49302213_T_A	5.782019897669962e-06,7.19205729889027e-06,1.709904241092868e-05,7.19205729889027e-06,5.51522445922424e-05	0.0014702427553570136,0.0018428609815186782,0.0024991863535684788,0.0018428609815186782,0.0003850173954240535
egfr	CCDC12_4	chr3_46922012_T_C,chr3_46923707_C_G,chr3_46941247_T_C,chr3_46923591_T_G	5.914685515407129e-06,0.0018228664081414493,0.005309522612383735,0.004983454832882268	0.030142804350997518,0.03284103078371856,0.032410896819240385,0.04034475330385405
egfr	TRIOBP_4	chr22_37723206_G_A,chr22_37734378_A_C,chr22_37765828_T_TG,chr22_37750578_C_T	5.971478816203375e-05,0.00027985715683595134,0.00029261375791339014,0.0030808446512811693	0.0051569691660451255,0.009407307485487609,0.022947122514129482,0.01009941891139795
egfr	RAF1_2	chr3_12603508_C_T,chr3_12606048_T_TG	6.128646872671697e-07,0.0039523881023646075	0.0022616226810353037,8.653379217936721e-05
egfr	FMNL1_5	chr17_45241411_G_C,chr17_45241412_C_G,chr17_45243751_T_G,chr17_45232440_T_G,chr17_45244864_G_C	6.171874985510183e-05,0.00015929956646855425,0.003538404752618725,0.004784366369409091,3.9901595948387376e-05	0.0020906187745857413,0.0076474907511281205,0.013884774496511404,0.006430399709476225,0.0024365462048673877
egfr	RIPK4_2	chr21_41746606_T_G,chr21_41746170_T_C	6.423837221659731e-05,0.00010177497615683857	0.014247426375762309,0.03297049438127817
egfr	AGPAT5_2	chr8_6724964_A_C,chr8_6757085_A_G	6.429038885162565e-07,0.00364477408851887	1.266950151869815e-06,0.001321765776974001
egfr	USP48_3	chr1_21703696_T_C,chr1_21706077_T_G,chr1_21706735_G_A	6.450311033122228e-05,0.00028299304853152363,0.00012669514216415802	0.007845997236531468,0.01309954874203597,0.004449445235290158
egfr	AP1M1_8	chr19_16206608_T_TG,chr19_16226612_T_C,chr19_16227721_G_A,chr19_16228258_G_A,chr19_16228904_C_T,chr19_16233717_C_G,chr19_16234288_T_C,chr19_16228794_T_G	6.528413032668653e-05,0.0064557081074910596,0.0024361725049911105,0.01837918810861549,0.025114292331133558,6.165054004198194e-05,0.002051667150159714,0.0008804072022582094	0.0008868669473225051,0.01491435109247843,0.00492438514382162,0.0030213758122107693,0.00454785100704076,6.396974124132157e-05,0.007302514064743812,0.008904488847639608
egfr	DAZAP1_2	chr19_1432575_T_C,chr19_1432578_A_C	6.972933286419396e-09,0.00010616832462214354	0.008783799588482919,0.004625103934387489
egfr	PACSIN3_2	chr11_47180569_G_A,chr11_47182508_A_C	7.134768403726839e-05,0.04020981298829434	0.021285924311691296,0.004000006496631303
egfr	R3HCC1_4	chr8_23288582_A_G,chr8_23291465_G_T,chr8_23293365_T_G,chr8_23290051_G_A	7.2991599811489e-05,5.994421359171259e-05,0.012526023152146196,0.010041573920909331	0.02377854438814787,0.02377854438814787,9.39093538138813e-05,0.0033896878620269183
egfr	SERPINB5_10	chr18_63486810_T_C,chr18_63487155_C_T,chr18_63489373_G_C,chr18_63493054_T_C,chr18_63493152_T_C,chr18_63503267_T_C,chr18_63503488_T_C,chr18_63503549_A_G,chr18_63503234_G_A,chr18_63504446_A_T	7.512909343200293e-07,1.61367941078967e-12,0.0017661748524282887,0.00358191163139034,1.15283914089761e-08,3.707481964958598e-05,3.699707858963291e-05,1.4974781606492456e-10,8.547425345240158e-05,0.001617719369677095	0.002310192116365421,0.0001900079796436893,0.0024982561142762962,0.004570527834506507,2.6119929305428517e-05,0.004811319593060203,0.00038813827261946135,0.0001894559075360232,0.008723212833525323,0.023248521588281557
egfr	U2AF1_2	chr21_43107500_A_C,chr21_43107485_A_C	7.700487442691808e-05,0.0006563940756543221	3.5456060624197415e-05,0.0031649133811599275
egfr	LLGL2_4	chr17_75569181_T_A,chr17_75558442_C_G,chr17_75573695_C_CCT,chr17_75575074_T_C	7.971949158890872e-06,3.785506483286314e-07,0.0064833437780985005,0.00395910816955325	0.018355040177942674,0.0004418073280201704,0.047670437975331784,0.004283559000108913
egfr	PPFIA1_4	chr11_70365468_A_G,chr11_70375250_G_T,chr11_70337631_C_G,chr11_70331778_TCAAAAA_T	8.1777600824213e-05,2.2154751602898654e-10,0.007683460638024795,2.733195536548977e-07	0.01601938240153477,1.0104020665663723e-05,0.008528354106314544,0.002219921170959074
egfr	STAG3_2	chr7_100197862_A_C,chr7_100182660_G_A	8.238419261021031e-05,0.008737491145039442	0.0017528283507844654,0.035261037489752685
egfr	MYO5B_13	chr18_49837561_G_C,chr18_49875910_A_C,chr18_49937217_A_G,chr18_49954290_G_A,chr18_49847096_G_A,chr18_49849562_C_G,chr18_49849733_C_G,chr18_49880543_A_G,chr18_49880568_T_C,chr18_49929553_C_T,chr18_49929610_GA_G,chr18_49954528_T_C,chr18_49962255_A_G	8.380774951798238e-06,0.006905476699523033,2.4263131433880795e-10,1.7494996128043332e-06,5.5387782704635815e-05,3.8985071268389133e-07,7.81858565470932e-07,1.54439656564615e-07,2.371423829111085e-08,8.182928222668989e-13,1.4176493799349745e-07,2.0981325041460703e-11,3.691444258026264e-11	0.03791686668587351,0.011592306302894794,0.0007689742137758647,0.011825548378506088,0.024802045476053625,0.0005688441791387698,0.0007265409595720793,0.010189243521059816,0.00680321425888459,7.83580041933832e-07,0.004868666362089778,9.442141848800156e-05,0.00020102188598339758
egfr	ZNF441_2	chr19_11767280_T_G,chr19_11778532_C_T	8.6437303626739e-08,3.655373741478951e-07	0.00119501780413069,0.007941778018462287
egfr	FAM83H_3	chr8_143728128_T_G,chr8_143725596_G_C,chr8_143730455_T_G	9.215742981089235e-05,0.005987749784597274,0.0009621524329080232	0.005904909381665708,0.003207570177222234,0.011128551580065676
egfr	KCNAB2_4	chr1_6085319_C_T,chr1_6095272_T_C,chr1_6085347_G_A,chr1_6094357_C_T	9.311243022811629e-05,0.0002214464879819671,0.007488052354416149,0.0004024482530986694	0.04271710391545418,0.04289813943359165,0.010697792728178102,0.030197643178852058
egfr	MMP15_4	chr16_58038249_C_T,chr16_58042518_A_G,chr16_58045261_G_A,chr16_58037634_A_C	9.375120301838935e-05,1.005487978512005e-05,0.00013842386491697844,0.035127559966572304	0.006545735139458929,0.008269298799745639,0.016496855574598585,3.732680793190984e-05
egfr	PKNOX1_3	chr21_43028653_G_C,chr21_43028665_G_A,chr21_43029807_G_A	9.45086875135022e-05,9.45086875135022e-05,0.0028391505331848486	0.02993846952653303,0.02993846952653303,0.04630035756513505
egfr	CNOT6L_3	chr4_77720488_T_G,chr4_77720486_A_G,chr4_77726534_A_C	9.499774295611595e-07,0.0011515987198065605,1.5337206523072135e-05	0.00045440611666765506,0.003812687853894012,0.002323583718729919
egfr	C1orf109_4	chr1_37683521_C_T,chr1_37689469_G_GGT,chr1_37689593_G_C,chr1_37684175_A_G	9.499906971175951e-07,3.357943291134777e-07,2.4786643546299445e-07,0.03129818295251388	0.0019238150218027989,0.005985910424044681,0.004025869106193675,0.0047335795687796075
egfr	MAP7_2	chr6_136361034_G_A,chr6_136411526_G_A	9.631600220201912e-05,0.00020915694169969668	0.004233710215813943,0.03701019146859175

ERK MAPK signaling 약물에 대한 반응성 바이오 마커

Drug_Class	Gene_exp	바이오마커 ( 발현조절변이세트 )
erk_mapk	Gene_EXP:MARCH4	6_151015603_C_G
erk_mapk	Gene_EXP:MARCH9	14_30910985_T_G
erk_mapk	Gene_EXP:SEPT59	1_26457907_T_G
erk_mapk	Gene_EXP:ABCA5	6_151015603_C_G
erk_mapk	Gene_EXP:ABCA5	17_50677651_A_G,17_78529677_G_C
erk_mapk	Gene_EXP:ABCB10	3_52786995_A_G
erk_mapk	Gene_EXP:ABHD3	17_68269074_G_C
erk_mapk	Gene_EXP:ABHD6	12_67294938_G_A
erk_mapk	Gene_EXP:ACCS	11_44107740_C_A,7_135196179_C_T,9_61066407_C_T
erk_mapk	Gene_EXP:ACN9	2_3465735_T_C
erk_mapk	Gene_EXP:ACSF2	2_71393433_A_G,2_71424561_G_GT,2_71428456_T_A,2_71433365_T_TC
erk_mapk	Gene_EXP:ACSS2	8_143538013_T_C
erk_mapk	Gene_EXP:ACVR2B	14_92931686_G_C,14_92931733_G_A
erk_mapk	Gene_EXP:ADAT2	5_141490949_A_G,17_41827392_A_C
erk_mapk	Gene_EXP:ADCY7	16_15664876_A_C
erk_mapk	Gene_EXP:ADCYAP1	12_96909915_A_C
erk_mapk	Gene_EXP:ADNP2	9_41294004_C_A
erk_mapk	Gene_EXP:AFAP1L2	2_39717176_T_G
erk_mapk	Gene_EXP:AGPAT2	21_25714604_C_A
erk_mapk	Gene_EXP:AGTRAP	2_178769706_G_T
erk_mapk	Gene_EXP:AHI1	2_102664958_A_C
erk_mapk	Gene_EXP:AIM1	11_124396830_G_A
erk_mapk	Gene_EXP:ALDH3A1	21_41825867_C_T
erk_mapk	Gene_EXP:ALG6	1_26457907_T_G
erk_mapk	Gene_EXP:ALG9	14_76498312_C_T
erk_mapk	Gene_EXP:AMD1	1_103003299_TA_T,5_7817145_GA_G,11_36280860_GA_G,15_22573938_CT_C
erk_mapk	Gene_EXP:AMIGO2	19_2109072_C_T,19_2109158_T_C,19_2121317_C_T,19_2123329_A_G
erk_mapk	Gene_EXP:ANKMY1	12_103753400_C_A
erk_mapk	Gene_EXP:ANKRD22	17_81206909_A_C
erk_mapk	Gene_EXP:ANKRD28	1_26457907_T_G
erk_mapk	Gene_EXP:ANKRD46	5_124701240_T_G
erk_mapk	Gene_EXP:ANO1	4_36121402_A_G
erk_mapk	Gene_EXP:ANO4	9_41294004_C_A
erk_mapk	Gene_EXP:ANO5	12_9427796_G_T
erk_mapk	Gene_EXP:ANPEP	2_182063828_G_C,3_75338856_G_A
erk_mapk	Gene_EXP:AP1S2	1_13225346_G_A,1_13345267_G_A,12_67294938_G_A
erk_mapk	Gene_EXP:AP2S1	10_68572309_C_T
erk_mapk	Gene_EXP:AP3M2	17_8888776_G_A
erk_mapk	Gene_EXP:APBB1	7_117548606_ATG_A
erk_mapk	Gene_EXP:APEH	15_70699666_A_G
erk_mapk	Gene_EXP:APOC1	5_54519891_G_C
erk_mapk	Gene_EXP:ARHGAP22	5_41008678_A_G,5_41009140_C_T,11_130470775_T_C
erk_mapk	Gene_EXP:ARID1B	1_169953900_G_GT
erk_mapk	Gene_EXP:ARL3	2_182063828_G_C
erk_mapk	Gene_EXP:ARL6IP6	2_178707495_G_T,4_51995319_G_T,17_42806693_T_C,17_43189040_A_C
erk_mapk	Gene_EXP:ARPC1A	9_39118208_G_T,9_41938349_G_T,9_61081995_G_T
erk_mapk	Gene_EXP:ARRB1	16_46710765_T_A
erk_mapk	Gene_EXP:ARSD	1_101786406_G_A
erk_mapk	Gene_EXP:ARVCF	10_133626829_C_T,15_71256598_T_C
erk_mapk	Gene_EXP:ASB8	19_35904227_A_C
erk_mapk	Gene_EXP:ASGR2	6_138499187_A_G,10_38696926_C_T
erk_mapk	Gene_EXP:ASH2L	9_33796659_C_T,9_33796705_C_G,9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
erk_mapk	Gene_EXP:ASTN1	7_152816454_C_T
erk_mapk	Gene_EXP:ATG4D	19_12392240_G_A,19_12392282_A_G,19_12393278_A_G,19_12431541_A_G,19_12433052_A_G
erk_mapk	Gene_EXP:ATG7	7_140753336_A_T,16_84170124_G_C
erk_mapk	Gene_EXP:ATHL1	3_125578903_AT_A
erk_mapk	Gene_EXP:ATP11A	2_85880864_T_C,3_132388903_G_A,9_128288585_G_C
erk_mapk	Gene_EXP:ATP1A1	1_26457907_T_G
erk_mapk	Gene_EXP:ATP2B3	1_26457907_T_G,17_7604041_A_C
erk_mapk	Gene_EXP:ATP6V0B	1_9850602_T_G
erk_mapk	Gene_EXP:ATP6V0B	17_78529723_C_G
erk_mapk	Gene_EXP:ATP6V1G1	19_35904227_A_C
erk_mapk	Gene_EXP:AVPI1	3_157413999_A_C
erk_mapk	Gene_EXP:AXL	4_42616004_T_TA,4_42616121_A_G
erk_mapk	Gene_EXP:AXL	14_73713060_A_C
erk_mapk	Gene_EXP:AZU1	2_135023465_C_T,2_135133038_G_C,11_129905704_C_T
erk_mapk	Gene_EXP:B3GNT8	3_74301846_T_C,17_7771466_C_T,17_7801487_C_G
erk_mapk	Gene_EXP:BAALC	15_67236036_T_G
erk_mapk	Gene_EXP:BANP	9_33270750_G_T
erk_mapk	Gene_EXP:BARD1	9_133405414_T_G
erk_mapk	Gene_EXP:BAZ2A	6_83940645_G_T
erk_mapk	Gene_EXP:BHLHE22	1_26457907_T_G,22_21127217_C_G
erk_mapk	Gene_EXP:BIRC7	17_78507511_T_C,17_78510525_G_A
erk_mapk	Gene_EXP:BLCAP	4_48609132_A_G
erk_mapk	Gene_EXP:BMP7	5_119530001_T_C
erk_mapk	Gene_EXP:BPNT1	2_100964113_G_A,2_100977729_C_T
erk_mapk	Gene_EXP:BST1	3_75338856_G_A
erk_mapk	Gene_EXP:C10orf11	1_13344015_T_C
erk_mapk	Gene_EXP:C10orf76	2_169557387_G_GA
erk_mapk	Gene_EXP:C11orf74	2_216109160_C_A,2_237751320_TAA_T,13_49377006_T_C,16_21520152_G_A,16_21533198_T_C
erk_mapk	Gene_EXP:C12orf49	21_29056427_GTAC_G
erk_mapk	Gene_EXP:C12orf57	1_103082763_C_G
erk_mapk	Gene_EXP:C14orf142	11_66055499_T_G
erk_mapk	Gene_EXP:C16orf59	2_217847583_C_T,2_217847883_G_A
erk_mapk	Gene_EXP:C17orf53	2_131597280_C_G,17_6998597_A_C,19_39885857_T_G
erk_mapk	Gene_EXP:C17orf75	6_32183680_C_G
erk_mapk	Gene_EXP:C1orf198	18_6985656_C_T
erk_mapk	Gene_EXP:C1orf198	3_98581510_A_C,5_1079483_A_C,12_121263747_T_G,20_6215106_T_C
erk_mapk	Gene_EXP:C1QTNF1	4_106337071_G_A
erk_mapk	Gene_EXP:C2CD2L	1_158255229_C_G
erk_mapk	Gene_EXP:C3AR1	7_147977856_A_T
erk_mapk	Gene_EXP:C5orf34	7_22511655_A_C
erk_mapk	Gene_EXP:C5orf54	19_10499560_A_G
erk_mapk	Gene_EXP:C9orf123	9_41898374_T_G
erk_mapk	Gene_EXP:C9orf50	6_30713139_C_T
erk_mapk	Gene_EXP:C9orf69	2_9954891_G_GT,2_9996464_T_C
erk_mapk	Gene_EXP:CA2	1_156378043_T_A
erk_mapk	Gene_EXP:CABP7	1_46344858_A_G
erk_mapk	Gene_EXP:CACNA2D2	15_67236036_T_G
erk_mapk	Gene_EXP:CACNG4	6_5771301_A_C,7_140753336_A_T,16_11174168_A_G
erk_mapk	Gene_EXP:CAMK2D	2_100964113_G_A,2_100977729_C_T,11_45181661_C_T
erk_mapk	Gene_EXP:CAMK4	7_127596284_C_G
erk_mapk	Gene_EXP:CAND2	X_101102205_C_G,X_101102212_T_C,X_101102428_CT_C
erk_mapk	Gene_EXP:CASP8	17_75904383_G_C
erk_mapk	Gene_EXP:CATSPER1	7_140753336_A_T
erk_mapk	Gene_EXP:CAV1	10_133626829_C_T
erk_mapk	Gene_EXP:CBLN2	1_170016655_A_G
erk_mapk	Gene_EXP:CCDC136	9_131430074_C_T,19_11301321_TA_T
erk_mapk	Gene_EXP:CCDC14	7_33357933_C_A,9_33529025_G_T
erk_mapk	Gene_EXP:CCDC142	9_85773919_A_G
erk_mapk	Gene_EXP:CCNF	19_9566733_T_G
erk_mapk	Gene_EXP:CD151	11_828784_A_G,11_840477_A_G,11_840319_C_T,11_838110_C_T,11_837582_G_A
erk_mapk	Gene_EXP:CD151	3_3845163_G_C,3_3845235_C_T
erk_mapk	Gene_EXP:CD44	8_132137720_G_A
erk_mapk	Gene_EXP:CD55	5_113384951_C_A
erk_mapk	Gene_EXP:CD59	6_151015603_C_G
erk_mapk	Gene_EXP:CD72	2_138288359_C_T
erk_mapk	Gene_EXP:CD97	4_8036186_A_G,5_141193109_A_G,7_108514148_A_C,12_108517007_T_G,17_80137479_A_T
erk_mapk	Gene_EXP:CDC25A	14_55169342_TAAA_T,19_9566733_T_G
erk_mapk	Gene_EXP:CDCP1	22_24253656_C_G
erk_mapk	Gene_EXP:CEBPD	6_150926303_A_G
erk_mapk	Gene_EXP:CECR2	15_30596563_A_G
erk_mapk	Gene_EXP:CENPM	19_10793898_A_C
erk_mapk	Gene_EXP:CEP104	20_14326307_G_T
erk_mapk	Gene_EXP:CEP41	13_36365551_C_T
erk_mapk	Gene_EXP:CES2	8_17085328_C_T
erk_mapk	Gene_EXP:CHGB	15_67236036_T_G
erk_mapk	Gene_EXP:CHI3L2	3_7691039_AT_A,5_146267624_CT_C
erk_mapk	Gene_EXP:CHID1	1_53250744_G_A,1_85071819_T_A,15_78922969_A_C,15_78939184_A_AG
erk_mapk	Gene_EXP:CHN1	17_81206909_A_C
erk_mapk	Gene_EXP:CHST8	11_5901136_G_A
erk_mapk	Gene_EXP:CITED4	3_75338856_G_A
erk_mapk	Gene_EXP:CLCNKA	10_31363289_T_C
erk_mapk	Gene_EXP:CLEC11A	5_179863845_T_G,16_46710765_T_A
erk_mapk	Gene_EXP:CLIP3	5_163482681_G_A
erk_mapk	Gene_EXP:CLSPN	15_62651935_A_G,15_62657955_G_C
erk_mapk	Gene_EXP:CMBL	11_117203393_G_A
erk_mapk	Gene_EXP:CMIP	16_85071785_A_G
erk_mapk	Gene_EXP:COL4A5	3_38092947_A_G
erk_mapk	Gene_EXP:COMT	8_143538172_T_C,8_143538914_T_G
erk_mapk	Gene_EXP:COPS8	11_69072603_C_T,11_124023539_A_G,11_124023038_C_T,16_57082546_T_C,16_57081660_C_T
erk_mapk	Gene_EXP:CORO2A	12_67294938_G_A
erk_mapk	Gene_EXP:CPNE8	X_24055660_C_A
erk_mapk	Gene_EXP:CRNKL1	19_49365896_G_C
erk_mapk	Gene_EXP:CRYBA2	17_19742625_A_C
erk_mapk	Gene_EXP:CSF2	X_73845822_T_G
erk_mapk	Gene_EXP:CSRNP1	2_95859892_G_T,8_7952044_T_C
erk_mapk	Gene_EXP:CTGF	10_99533046_A_G
erk_mapk	Gene_EXP:CTRB2	4_37433902_C_T,17_32933237_C_T,17_32934364_G_A
erk_mapk	Gene_EXP:CTSL1	10_120866541_C_T,17_75130604_T_G,10_62069760_A_C,7_6857531_A_G,X_52907336_A_C
erk_mapk	Gene_EXP:CTSL1	10_120866541_C_T,10_62069760_A_C,X_52907336_A_C,20_57610424_A_C,17_75130604_T_G
erk_mapk	Gene_EXP:CTSL1	17_75130604_T_G,10_62069760_A_C,10_120866541_C_T,7_6857531_A_G,20_57610424_A_C
erk_mapk	Gene_EXP:CXCL2	12_883063_C_T,12_895996_T_C
erk_mapk	Gene_EXP:CXCL2	X_89922110_G_C
erk_mapk	Gene_EXP:CXXC1	2_119254595_G_A,3_112199369_A_G
erk_mapk	Gene_EXP:CYP4F22	22_21127217_C_G
erk_mapk	Gene_EXP:DCTD	8_7429219_C_T
erk_mapk	Gene_EXP:DDO	1_154732996_T_G
erk_mapk	Gene_EXP:DDOST	7_36335190_G_A,4_133154998_T_C,1_147255938_G_A,7_74535081_T_C,6_10415074_C_G
erk_mapk	Gene_EXP:DDR1	2_174801578_A_G,4_89936328_G_A
erk_mapk	Gene_EXP:DDX60L	6_143772215_C_T
erk_mapk	Gene_EXP:DGAT1	3_38905381_A_T,3_38910262_T_C,11_18484005_G_A
erk_mapk	Gene_EXP:DKK3	11_24729296_G_A
erk_mapk	Gene_EXP:DLC1	2_182063828_G_C,20_56366031_C_T
erk_mapk	Gene_EXP:DLG2	1_26457907_T_G,22_18847351_G_C,22_21127217_C_G
erk_mapk	Gene_EXP:DNMT3A	22_36566306_C_G
erk_mapk	Gene_EXP:DOCK4	7_140753336_A_T,9_76227464_A_G
erk_mapk	Gene_EXP:DOCK5	5_32053643_T_C
erk_mapk	Gene_EXP:DOCK9	2_87800520_G_A,17_80065379_A_G
erk_mapk	Gene_EXP:DOK6	18_12840880_T_C
erk_mapk	Gene_EXP:DPP9	22_21127217_C_G
erk_mapk	Gene_EXP:DPY19L3	15_65564315_G_A,17_78425362_G_A,17_78427070_C_T
erk_mapk	Gene_EXP:DPYSL4	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G,2_217842134_T_C,2_217847379_A_G
erk_mapk	Gene_EXP:DPYSL5	1_26457907_T_G,22_21127217_C_G
erk_mapk	Gene_EXP:DQX1	1_113907966_C_T
erk_mapk	Gene_EXP:DTL	2_29239654_G_A
erk_mapk	Gene_EXP:DTX3L	4_185267219_TA_T
erk_mapk	Gene_EXP:DUSP5	6_32183680_C_G
erk_mapk	Gene_EXP:DYSF	1_25390874_C_G,20_14326307_G_T
erk_mapk	Gene_EXP:E2F4	17_3727947_A_G
erk_mapk	Gene_EXP:EBP	14_91475998_T_A
erk_mapk	Gene_EXP:EBPL	19_7640893_A_C
erk_mapk	Gene_EXP:ECE1	7_100105324_G_A,7_101031028_C_T,17_49510638_C_T,20_32983679_C_T,12_50400904_T_G
erk_mapk	Gene_EXP:ELK3	14_21082261_T_G
erk_mapk	Gene_EXP:ELL2	6_32183680_C_G
erk_mapk	Gene_EXP:ELOVL1	1_203683316_A_G,1_203698281_T_C
erk_mapk	Gene_EXP:EMILIN2	5_179863845_T_G
erk_mapk	Gene_EXP:ENC1	1_26457907_T_G,15_69422319_A_C
erk_mapk	Gene_EXP:ENDOD1	1_201000288_T_G
erk_mapk	Gene_EXP:ENG	3_186558604_C_T,22_29806785_G_C
erk_mapk	Gene_EXP:EPB41	11_1758992_A_C
erk_mapk	Gene_EXP:EPS8L1	2_206143951_C_CT,2_206144039_C_A,2_206160720_T_C,2_206176329_T_C
erk_mapk	Gene_EXP:ERAP2	5_96986715_C_T,5_96917400_T_C,5_97003398_AC_A,5_97027703_C_T,5_96908881_A_C
erk_mapk	Gene_EXP:ERAP2	5_96986715_C_T,5_96917400_T_C,5_97003398_AC_A,5_96908881_A_C,5_96895179_A_ATT
erk_mapk	Gene_EXP:ERC2	22_36566306_C_G
erk_mapk	Gene_EXP:EREG	17_50677651_A_G
erk_mapk	Gene_EXP:ERH	6_47579334_T_TAA
erk_mapk	Gene_EXP:ERMAP	10_111079134_C_A,4_25662622_G_A,2_160137837_C_T,2_182063828_G_C,2_160138253_A_G
erk_mapk	Gene_EXP:ERO1L	6_47579334_T_TAA
erk_mapk	Gene_EXP:ERRFI1	17_41820457_A_C
erk_mapk	Gene_EXP:EVL	7_33264495_A_G
erk_mapk	Gene_EXP:EVPL	15_84798628_G_A
erk_mapk	Gene_EXP:EXOG	11_102186007_C_T,16_89792351_C_T
erk_mapk	Gene_EXP:EXOSC8	2_127651579_A_C,6_30705792_T_G,6_73622013_G_C,6_73635330_C_T
erk_mapk	Gene_EXP:EXT2	7_100959168_T_C,7_100959203_T_C
erk_mapk	Gene_EXP:EZH2	1_26457907_T_G,22_18847351_G_C
erk_mapk	Gene_EXP:FAM102A	20_10639738_A_G
erk_mapk	Gene_EXP:FAM111B	19_49044175_A_G
erk_mapk	Gene_EXP:FAM114A1	2_217847583_C_T
erk_mapk	Gene_EXP:FAM124A	1_26457907_T_G,1_219210601_T_G
erk_mapk	Gene_EXP:FAM63A	16_84779142_A_C
erk_mapk	Gene_EXP:FAM83H	2_219489820_G_A,6_56701823_T_C
erk_mapk	Gene_EXP:FBN2	3_52520584_A_C
erk_mapk	Gene_EXP:FBXO10	7_72961358_G_A,7_73180651_C_T,7_75212025_G_A,7_75403732_C_T,17_63918839_T_A
erk_mapk	Gene_EXP:FBXO21	17_47835431_A_G,5_176575304_A_C,10_37162775_G_C,2_223598038_G_T,2_130173628_A_C
erk_mapk	Gene_EXP:FBXO33	8_143538013_T_C
erk_mapk	Gene_EXP:FCER1G	10_47353252_A_G
erk_mapk	Gene_EXP:FCGR2A	10_18500795_T_G
erk_mapk	Gene_EXP:FCRLB	12_49974763_C_G,1_183239405_G_A,10_102365533_A_G,2_118982373_A_G,X_52907336_A_C
erk_mapk	Gene_EXP:FEZ2	X_108735142_T_G
erk_mapk	Gene_EXP:FGF9	13_32131648_A_G
erk_mapk	Gene_EXP:FGFBP1	2_65069680_A_C,17_81206909_A_C
erk_mapk	Gene_EXP:FHL3	11_65543121_A_C
erk_mapk	Gene_EXP:FHL3	1_50200843_C_T
erk_mapk	Gene_EXP:FHOD1	2_219250419_G_C,16_48167297_T_G,6_34872273_T_G,21_46245169_G_A,10_96386941_T_G
erk_mapk	Gene_EXP:FKBP3	3_10301192_C_T,15_22715140_G_C
erk_mapk	Gene_EXP:FRAT2	1_215813880_T_C,1_215838019_T_C
erk_mapk	Gene_EXP:FYN	X_120253978_C_CTGA
erk_mapk	Gene_EXP:GAL	22_20751638_T_G
erk_mapk	Gene_EXP:GAL3ST3	1_26457907_T_G
erk_mapk	Gene_EXP:GALNT10	13_99295007_C_T,13_99314037_A_G
erk_mapk	Gene_EXP:GALNT6	X_154465468_T_C
erk_mapk	Gene_EXP:GATA2	2_182063828_G_C
erk_mapk	Gene_EXP:GATA6	8_1678462_A_C,14_24330372_C_G
erk_mapk	Gene_EXP:GBP1	3_55480738_A_T
erk_mapk	Gene_EXP:GJB1	10_127125690_A_C,10_127127749_A_G
erk_mapk	Gene_EXP:GLIPR1	16_55398_G_T
erk_mapk	Gene_EXP:GLT25D1	5_135888024_G_T
erk_mapk	Gene_EXP:GLTP	2_182994745_T_C
erk_mapk	Gene_EXP:GLUL	16_46710765_T_A
erk_mapk	Gene_EXP:GMPR	2_182063828_G_C
erk_mapk	Gene_EXP:GNAO1	10_133626013_G_A
erk_mapk	Gene_EXP:GNGT2	19_49189116_C_G
erk_mapk	Gene_EXP:GPC1	3_184278425_C_T
erk_mapk	Gene_EXP:GPC2	5_141432375_A_C
erk_mapk	Gene_EXP:GPR18	2_1542589_G_T
erk_mapk	Gene_EXP:GPR87	19_15807367_G_T
erk_mapk	Gene_EXP:GPX1	12_49974763_C_G,2_85665590_T_G,19_38802052_C_G,6_43512063_C_G,11_117913802_T_G
erk_mapk	Gene_EXP:GPX1	19_38802052_C_G,6_43512063_C_G,11_117913802_T_G,12_49974763_C_G,2_85665590_T_G
erk_mapk	Gene_EXP:GRB10	7_51028450_A_G,12_56425138_C_T
erk_mapk	Gene_EXP:GSN	11_129905704_C_T
erk_mapk	Gene_EXP:GSN	2_170993697_G_A
erk_mapk	Gene_EXP:GSTA4	17_80065379_A_G
erk_mapk	Gene_EXP:GSTO1	1_109507591_A_C
erk_mapk	Gene_EXP:HADHB	19_48942517_C_T,19_48944320_G_A,19_48944456_G_A
erk_mapk	Gene_EXP:HBEGF	9_61862148_G_A
erk_mapk	Gene_EXP:HBEGF	4_38137040_C_T
erk_mapk	Gene_EXP:HDAC6	13_45503246_G_A
erk_mapk	Gene_EXP:HEBP1	2_182063828_G_C
erk_mapk	Gene_EXP:HERC4	Y_11344982_T_A
erk_mapk	Gene_EXP:HFM1	17_36013794_G_A
erk_mapk	Gene_EXP:HIBADH	1_485270_G_A
erk_mapk	Gene_EXP:HIPK1	X_12976206_T_G
erk_mapk	Gene_EXP:HIST1H2BG	14_77243033_A_C
erk_mapk	Gene_EXP:HIST1H2BK	5_150396348_A_C,6_132814681_A_G
erk_mapk	Gene_EXP:HIST2H2BE	6_132814681_A_G
erk_mapk	Gene_EXP:HK1	16_74886293_G_A
erk_mapk	Gene_EXP:HMGA1	20_49248835_G_A,20_49270147_G_A
erk_mapk	Gene_EXP:HNMT	1_1756186_T_C
erk_mapk	Gene_EXP:HOXA1	11_3410400_C_T
erk_mapk	Gene_EXP:HR	2_87128802_G_A
erk_mapk	Gene_EXP:HS3ST1	19_17422317_A_G
erk_mapk	Gene_EXP:HS3ST4	1_26457907_T_G,12_52771095_C_G
erk_mapk	Gene_EXP:HSD17B10	5_24511259_C_T
erk_mapk	Gene_EXP:IBA57	1_21472921_G_A,10_50850592_T_TTG,17_76280234_G_A
erk_mapk	Gene_EXP:ICAM1	8_12358868_A_G
erk_mapk	Gene_EXP:ID4	4_9334816_T_C
erk_mapk	Gene_EXP:IER5L	9_34623341_A_G
erk_mapk	Gene_EXP:IFI35	12_15589379_GA_G
erk_mapk	Gene_EXP:IFIT3	18_50806833_C_G
erk_mapk	Gene_EXP:IFIT5	6_169632990_G_A,6_169665646_G_A
erk_mapk	Gene_EXP:IGF2BP2	1_39522547_C_T
erk_mapk	Gene_EXP:IKBIP	5_141636680_A_C
erk_mapk	Gene_EXP:IL13RA1	1_26457907_T_G
erk_mapk	Gene_EXP:IL15RA	22_36566306_C_G
erk_mapk	Gene_EXP:IL15RA	7_126902472_G_A
erk_mapk	Gene_EXP:IL17RB	19_44506064_G_T
erk_mapk	Gene_EXP:IL31RA	4_20727343_G_C
erk_mapk	Gene_EXP:INSR	10_43845624_CATTGATT_C
erk_mapk	Gene_EXP:IRF1	3_177032946_G_C
erk_mapk	Gene_EXP:IRX2	1_2562891_G_A,7_140753336_A_T,12_14460981_T_A
erk_mapk	Gene_EXP:ISG20	5_179863845_T_G
erk_mapk	Gene_EXP:ITGA3	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G
erk_mapk	Gene_EXP:ITGA6	7_74046648_T_G
erk_mapk	Gene_EXP:ITGAV	3_180647255_T_TA
erk_mapk	Gene_EXP:ITGB1	1_13345267_G_A
erk_mapk	Gene_EXP:ITGB4	9_88647579_G_T,20_32983679_C_T
erk_mapk	Gene_EXP:ITGBL1	1_26457907_T_G
erk_mapk	Gene_EXP:ITM2A	1_26457907_T_G
erk_mapk	Gene_EXP:ITPRIPL1	22_36800827_G_A,22_36800927_C_A
erk_mapk	Gene_EXP:ITPRIPL1	2_24209270_T_C
erk_mapk	Gene_EXP:JAKMIP2	21_10605542_G_A
erk_mapk	Gene_EXP:JAKMIP2	22_21127217_C_G
erk_mapk	Gene_EXP:KCNJ11	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G,2_217848559_G_A
erk_mapk	Gene_EXP:KCNK6	17_81206909_A_C
erk_mapk	Gene_EXP:KCNMB2	18_50806833_C_G
erk_mapk	Gene_EXP:KCTD7	11_63646490_AAAAT_A,11_63719914_T_C,12_128669441_G_A
erk_mapk	Gene_EXP:KDM1B	15_65447029_G_A
erk_mapk	Gene_EXP:KDM3A	9_61211264_T_G
erk_mapk	Gene_EXP:KHK	2_217847583_C_T,2_217848003_A_G
erk_mapk	Gene_EXP:KHSRP	7_151377210_A_G
erk_mapk	Gene_EXP:KIAA1239	7_83961536_T_C
erk_mapk	Gene_EXP:KIAA1377	19_2896950_T_C
erk_mapk	Gene_EXP:KIAA1456	1_26457907_T_G,3_52520584_A_C,15_25177023_G_C,22_21127217_C_G,22_22643666_C_G
erk_mapk	Gene_EXP:KIDINS220	5_50403159_C_A
erk_mapk	Gene_EXP:KIFC3	1_207545558_G_A,1_207564114_G_A
erk_mapk	Gene_EXP:KLHDC3	15_82759440_C_T
erk_mapk	Gene_EXP:KLK6	4_48170201_C_T,4_48170249_G_A
erk_mapk	Gene_EXP:KRT10	2_97196659_G_A,7_92671549_C_T
erk_mapk	Gene_EXP:LAPTM4B	20_56366031_C_T
erk_mapk	Gene_EXP:LCK	1_220110770_GT_G,7_73465568_GA_G,2_161993434_TA_T,6_46668819_GT_G,5_64507681_TA_T
erk_mapk	Gene_EXP:LCK	7_73465568_GA_G,1_220110770_GT_G,2_161993434_TA_T,6_46668819_GT_G,5_64507681_TA_T
erk_mapk	Gene_EXP:LCN9	22_42070262_A_C
erk_mapk	Gene_EXP:LEF1	6_136108863_GA_G,11_63382198_CA_C,9_100450496_GT_G,1_151694350_CT_C,13_37746457_TAA_TA
erk_mapk	Gene_EXP:LGALS1	4_8036186_A_G
erk_mapk	Gene_EXP:LGALS12	7_128804766_A_G,7_128805316_G_A,14_63384641_T_C
erk_mapk	Gene_EXP:LGALS8	13_98000593_A_G
erk_mapk	Gene_EXP:LIG1	2_217847583_C_T,2_217848003_A_G
erk_mapk	Gene_EXP:LIMS1	8_138630731_T_C
erk_mapk	Gene_EXP:LIN7A	13_45541596_C_A
erk_mapk	Gene_EXP:LINGO1	1_26457907_T_G,11_66624536_A_C,22_21127217_C_G,22_22643666_C_G
erk_mapk	Gene_EXP:LMO3	1_26457907_T_G
erk_mapk	Gene_EXP:LPP	1_26457907_T_G
erk_mapk	Gene_EXP:LRCH2	19_1825787_T_TA
erk_mapk	Gene_EXP:LRFN5	10_3165440_A_G
erk_mapk	Gene_EXP:LRP10	1_26457907_T_G,12_52771095_C_G,22_22643666_C_G
erk_mapk	Gene_EXP:LRP3	9_77415913_G_T,1_165249397_C_G,3_75338856_G_A,6_159214911_T_G,7_81974555_G_GAA
erk_mapk	Gene_EXP:LRP3	1_165249397_C_G,9_77415913_G_T,3_75338856_G_A,6_159214911_T_G,7_81974555_G_GAA
erk_mapk	Gene_EXP:LRPAP1	7_36335190_G_A,22_39052745_T_C
erk_mapk	Gene_EXP:LRRC4C	12_52771095_C_G
erk_mapk	Gene_EXP:LRRN1	4_654142_G_A,10_26492426_T_C,14_67347493_A_C
erk_mapk	Gene_EXP:MAD2L2	7_117548606_ATG_A
erk_mapk	Gene_EXP:MAN1B1	19_57455681_G_T,19_57455765_G_A,19_57473550_A_G,19_57490144_T_A,19_57507480_A_G
erk_mapk	Gene_EXP:MAP2K6	6_151015603_C_G
erk_mapk	Gene_EXP:MAP4	7_33099535_G_A
erk_mapk	Gene_EXP:MBLAC1	3_179365291_C_T
erk_mapk	Gene_EXP:MCFD2	1_161518073_C_T,1_161518227_T_C
erk_mapk	Gene_EXP:MDFIC	14_64588098_C_T
erk_mapk	Gene_EXP:MEF2A	22_24321550_G_A
erk_mapk	Gene_EXP:MEIG1	17_2334690_C_A
erk_mapk	Gene_EXP:MET	10_133626012_T_A,10_133626013_G_A
erk_mapk	Gene_EXP:MFSD10	4_9230731_G_C
erk_mapk	Gene_EXP:MFSD12	12_67294938_G_A
erk_mapk	Gene_EXP:MFSD5	10_93374837_C_T,10_96386941_T_G,12_9153310_A_C
erk_mapk	Gene_EXP:MGLL	1_26457907_T_G,22_21127217_C_G,22_22643666_C_G
erk_mapk	Gene_EXP:MICAL2	6_151015603_C_G
erk_mapk	Gene_EXP:MICAL2	12_88053784_G_C,12_88054289_A_AT,12_88077197_T_G
erk_mapk	Gene_EXP:MICALL1	22_36566306_C_G
erk_mapk	Gene_EXP:MICALL2	2_182063828_G_C
erk_mapk	Gene_EXP:MLC1	1_26457907_T_G,7_72941936_T_C
erk_mapk	Gene_EXP:MLKL	17_80137479_A_T
erk_mapk	Gene_EXP:MMP14	1_16580833_G_T
erk_mapk	Gene_EXP:MMP14	15_99729430_G_C
erk_mapk	Gene_EXP:MMRN2	19_15807367_G_T
erk_mapk	Gene_EXP:MPP1	7_114663562_CT_C,9_33796659_C_T,9_33798019_A_G
erk_mapk	Gene_EXP:MRPS26	8_119240272_G_C
erk_mapk	Gene_EXP:MRPS34	3_180647255_T_TA
erk_mapk	Gene_EXP:MSI2	22_43972861_C_T
erk_mapk	Gene_EXP:MSRB3	3_52520584_A_C,22_37816755_A_G
erk_mapk	Gene_EXP:MYH9	1_26457907_T_G,22_21127217_C_G
erk_mapk	Gene_EXP:MYH9	22_36566306_C_G
erk_mapk	Gene_EXP:MYL6B	11_284257_G_A
erk_mapk	Gene_EXP:MYLK	1_203181080_G_A
erk_mapk	Gene_EXP:MYO1E	15_25170856_G_A,X_153670877_G_T
erk_mapk	Gene_EXP:MYO1F	10_18500795_T_G
erk_mapk	Gene_EXP:MYOF	1_26457907_T_G,5_141432375_A_C
erk_mapk	Gene_EXP:MYT1	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G
erk_mapk	Gene_EXP:N6AMT1	17_6755950_T_G
erk_mapk	Gene_EXP:NAP1L2	2_227244910_T_TG,5_7817145_GA_G
erk_mapk	Gene_EXP:NBN	5_38425215_C_G
erk_mapk	Gene_EXP:NCAPD3	17_8881770_A_C,17_8881775_C_T
erk_mapk	Gene_EXP:NDUFA13	17_78803816_A_G
erk_mapk	Gene_EXP:NEXN	11_124397016_A_G
erk_mapk	Gene_EXP:NFE2	2_182063828_G_C
erk_mapk	Gene_EXP:NFE2L3	5_113434330_T_G,22_32394994_C_G,X_119791251_A_C
erk_mapk	Gene_EXP:NFKBIZ	6_47579334_T_TAA
erk_mapk	Gene_EXP:NIP7	9_33529025_G_T,9_122724363_T_G
erk_mapk	Gene_EXP:NKAIN2	1_169804019_T_C
erk_mapk	Gene_EXP:NMNAT3	6_99568464_G_C
erk_mapk	Gene_EXP:NOL4	1_26270944_G_A
erk_mapk	Gene_EXP:NOTCH2	20_63940084_T_G
erk_mapk	Gene_EXP:NPW	1_26457907_T_G,3_52520584_A_C,15_69422319_A_C
erk_mapk	Gene_EXP:NRP1	3_180647255_T_TA,15_68718780_C_T
erk_mapk	Gene_EXP:NSMAF	1_117088769_T_C
erk_mapk	Gene_EXP:NT5E	1_169804019_T_C
erk_mapk	Gene_EXP:NUCB2	8_26370124_A_G
erk_mapk	Gene_EXP:NUDC	18_24064127_G_T
erk_mapk	Gene_EXP:NUP188	17_73203001_T_G
erk_mapk	Gene_EXP:NXNL2	12_54002598_T_G
erk_mapk	Gene_EXP:OAF	9_83976942_T_C,9_83978162_A_T
erk_mapk	Gene_EXP:OGDHL	9_114169165_T_C
erk_mapk	Gene_EXP:OPHN1	12_54002598_T_G
erk_mapk	Gene_EXP:ORMDL3	2_178769706_G_T,19_49044101_A_G
erk_mapk	Gene_EXP:OSBPL11	10_122336520_T_C,10_122336546_A_C,17_4896602_C_T
erk_mapk	Gene_EXP:OSBPL5	2_232380431_T_C
erk_mapk	Gene_EXP:OSCAR	20_23444001_C_T
erk_mapk	Gene_EXP:P2RY6	2_71418498_G_GT,2_71424561_G_GT
erk_mapk	Gene_EXP:P2RY6	2_71398637_G_A,2_71399439_CTA_C,2_71418498_G_GT,2_71424561_G_GT
erk_mapk	Gene_EXP:P4HB	2_71427045_G_A
erk_mapk	Gene_EXP:PANK3	8_8786072_C_G,8_8797513_C_T
erk_mapk	Gene_EXP:PAPD4	19_54274840_G_A
erk_mapk	Gene_EXP:PAPSS2	17_7388330_T_G
erk_mapk	Gene_EXP:PARP12	22_36566306_C_G
erk_mapk	Gene_EXP:PARP9	4_185267219_TA_T
erk_mapk	Gene_EXP:PAWR	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
erk_mapk	Gene_EXP:PAX3	12_67294938_G_A,11_4573507_G_GT,11_5489193_ATCT_A,3_14181724_C_T,22_31267999_C_T
erk_mapk	Gene_EXP:PCBP4	1_247588807_A_G
erk_mapk	Gene_EXP:PCDH7	11_64284449_A_C
erk_mapk	Gene_EXP:PCLO	1_56949637_G_A,1_56956838_C_T
erk_mapk	Gene_EXP:PCSK1N	15_74801109_A_C
erk_mapk	Gene_EXP:PDIA5	2_43676215_T_C,11_18534402_T_C
erk_mapk	Gene_EXP:PDLIM1	11_124186080_G_A,11_124224942_C_A
erk_mapk	Gene_EXP:PDLIM4	3_111845992_A_G
erk_mapk	Gene_EXP:PDLIM7	16_84872374_G_C
erk_mapk	Gene_EXP:PDP1	4_87811722_A_G,15_25189495_C_T,15_25199636_G_A,15_25185507_G_A,15_25194819_G_A
erk_mapk	Gene_EXP:PEG10	10_46549870_A_G
erk_mapk	Gene_EXP:PELI2	9_114169457_C_T,17_68420216_C_T
erk_mapk	Gene_EXP:PHACTR2	5_146013801_C_T
erk_mapk	Gene_EXP:PHC2	20_32983679_C_T
erk_mapk	Gene_EXP:PHF21B	11_124382822_G_A,11_124382854_G_A
erk_mapk	Gene_EXP:PIAS2	18_49837560_A_G,18_49837561_G_C
erk_mapk	Gene_EXP:PIDD	8_73322989_C_A
erk_mapk	Gene_EXP:PIEZO1	8_143649856_G_A,12_122781141_A_G,21_25592836_G_A,21_25592893_T_C,21_25597391_T_C
erk_mapk	Gene_EXP:PIGB	15_59207967_A_G,15_59207979_A_G,15_59207981_C_G,15_59207987_T_C
erk_mapk	Gene_EXP:PIK3CB	2_42288248_A_G,5_16474706_T_G
erk_mapk	Gene_EXP:PITX1	10_43373649_C_A
erk_mapk	Gene_EXP:PLA2G7	10_21612326_CT_C
erk_mapk	Gene_EXP:PLAGL1	7_93426338_G_A,11_118551711_A_G,14_104792556_A_G,16_28902389_G_T
erk_mapk	Gene_EXP:PLEKHN1	8_378251_A_G
erk_mapk	Gene_EXP:PLK2	1_26457907_T_G
erk_mapk	Gene_EXP:PLSCR5	9_111444272_T_G
erk_mapk	Gene_EXP:PLXNA3	1_113114916_G_A
erk_mapk	Gene_EXP:PNPLA8	17_21300996_G_T,17_21301003_T_C,17_21301006_A_G
erk_mapk	Gene_EXP:POC1A	22_46638059_A_C
erk_mapk	Gene_EXP:POLE	2_217847583_C_T
erk_mapk	Gene_EXP:POLE4	2_218618671_A_C,19_9611315_T_C,1_220001162_G_T,X_119085370_C_A,16_72107293_C_G
erk_mapk	Gene_EXP:PPM1K	5_179863845_T_G
erk_mapk	Gene_EXP:PPP1R13L	7_33099535_G_A
erk_mapk	Gene_EXP:PPP1R1A	1_26457907_T_G,5_141432375_A_C
erk_mapk	Gene_EXP:PPP1R1B	1_109626825_A_C,6_53899709_T_G,7_99012221_A_C
erk_mapk	Gene_EXP:PPP2R3C	5_97179013_C_G
erk_mapk	Gene_EXP:PPP6R1	17_43829748_T_G
erk_mapk	Gene_EXP:PPT1	11_85898919_C_T
erk_mapk	Gene_EXP:PRAM1	2_178769706_G_T,2_232380380_A_G,7_128805316_G_A
erk_mapk	Gene_EXP:PRDM15	1_26457907_T_G
erk_mapk	Gene_EXP:PRDM15	5_181333681_C_T
erk_mapk	Gene_EXP:PREP	22_32225632_C_T
erk_mapk	Gene_EXP:PREX1	9_34371054_A_C
erk_mapk	Gene_EXP:PRSS35	1_26457907_T_G
erk_mapk	Gene_EXP:PRSS57	9_33796659_C_T
erk_mapk	Gene_EXP:PSTPIP2	2_182063828_G_C,6_143760631_C_A,6_143772215_C_T
erk_mapk	Gene_EXP:PTBP2	15_59682341_T_A
erk_mapk	Gene_EXP:PTCHD4	11_4102115_C_G,11_4112087_C_A,11_4132537_A_G,11_4138236_G_A
erk_mapk	Gene_EXP:PTGFRN	5_126804830_T_C,5_126836282_C_T,11_1250937_C_T
erk_mapk	Gene_EXP:PTGR1	19_45698914_C_T
erk_mapk	Gene_EXP:PTGS2	11_86556636_G_A,11_86559642_C_T
erk_mapk	Gene_EXP:PTP4A3	X_92201459_T_G
erk_mapk	Gene_EXP:PTPN12	14_99909370_C_T
erk_mapk	Gene_EXP:PTPRO	1_169725777_A_G,1_169727805_G_A
erk_mapk	Gene_EXP:PTPRR	22_46283967_C_T
erk_mapk	Gene_EXP:PTX3	7_140753336_A_T,14_21082261_T_G
erk_mapk	Gene_EXP:PURG	5_141432375_A_C
erk_mapk	Gene_EXP:PVRL2	17_999610_T_C
erk_mapk	Gene_EXP:QDPR	X_153569278_T_C
erk_mapk	Gene_EXP:RAB21	2_29239654_G_A
erk_mapk	Gene_EXP:RAB2B	15_20251568_G_A
erk_mapk	Gene_EXP:RAB31	3_75338856_G_A
erk_mapk	Gene_EXP:RAB31	6_32027037_A_C,X_81277112_A_C
erk_mapk	Gene_EXP:RAB39B	8_2102806_A_G
erk_mapk	Gene_EXP:RABGAP1	3_10260372_A_G,17_20204460_T_C,17_20205876_C_T,17_20357788_A_G
erk_mapk	Gene_EXP:RAD1	7_22511655_A_C
erk_mapk	Gene_EXP:RAI14	5_94871301_T_G,14_21082261_T_G
erk_mapk	Gene_EXP:RALGPS1	7_100098747_C_G
erk_mapk	Gene_EXP:RAP2A	10_31363289_T_C
erk_mapk	Gene_EXP:RASA3	1_159858338_A_G,9_89037499_A_T,9_138176986_A_G,13_49892902_CT_C,13_49892908_G_C
erk_mapk	Gene_EXP:RBKS	7_140126550_T_A
erk_mapk	Gene_EXP:RBM11	1_26457907_T_G,5_141432375_A_C,19_624780_A_G,8_109483107_T_G,12_52771095_C_G
erk_mapk	Gene_EXP:RBM11	1_26457907_T_G,19_624780_A_G,5_141432375_A_C,8_109483107_T_G,22_18847351_G_C
erk_mapk	Gene_EXP:RBM18	10_131944182_G_C
erk_mapk	Gene_EXP:RCAN2	3_57289142_A_G
erk_mapk	Gene_EXP:REEP5	14_77243033_A_C
erk_mapk	Gene_EXP:REP15	8_69638689_A_C
erk_mapk	Gene_EXP:RFX3	7_67238251_A_AT
erk_mapk	Gene_EXP:RGS2	18_12978734_C_G
erk_mapk	Gene_EXP:RIC8B	3_39412024_A_G
erk_mapk	Gene_EXP:RIN3	6_38782929_A_G
erk_mapk	Gene_EXP:RNF145	15_65447029_G_A
erk_mapk	Gene_EXP:RNF207	9_134036501_T_G,16_68564104_A_G
erk_mapk	Gene_EXP:RNF24	5_179863845_T_G
erk_mapk	Gene_EXP:RNFT2	22_36566306_C_G
erk_mapk	Gene_EXP:ROPN1L	2_200876848_T_C,16_33978977_C_T
erk_mapk	Gene_EXP:ROR2	6_6305225_G_C,13_44436731_C_T
erk_mapk	Gene_EXP:RPL39L	17_61465729_T_C
erk_mapk	Gene_EXP:RPS6KA4	17_11923796_C_A
erk_mapk	Gene_EXP:RRM1	2_217847583_C_T
erk_mapk	Gene_EXP:RSBN1	2_127286836_G_C
erk_mapk	Gene_EXP:RUFY1	17_73212821_T_C
erk_mapk	Gene_EXP:RUNDC3B	4_68236279_G_GA
erk_mapk	Gene_EXP:RXRA	15_30087620_G_A,15_32400109_G_A
erk_mapk	Gene_EXP:S100A11	11_124145287_C_T
erk_mapk	Gene_EXP:S100A8	12_11091570_G_A
erk_mapk	Gene_EXP:S1PR2	1_204261453_G_A,3_54386725_A_G
erk_mapk	Gene_EXP:SBNO2	2_26503884_G_A
erk_mapk	Gene_EXP:SCAPER	2_68528704_T_C
erk_mapk	Gene_EXP:SCO2	X_14581235_C_G,X_14581237_T_G,X_55487442_C_G
erk_mapk	Gene_EXP:SDC1	1_26457907_T_G,3_52520584_A_C
erk_mapk	Gene_EXP:SDPR	15_23364667_T_G
erk_mapk	Gene_EXP:SEC24D	1_13345267_G_A
erk_mapk	Gene_EXP:SEMA4B	7_92469651_G_A
erk_mapk	Gene_EXP:SEMA6A	7_44801523_C_T
erk_mapk	Gene_EXP:SEMA7A	22_24253656_C_G
erk_mapk	Gene_EXP:SERINC3	2_25980839_T_G
erk_mapk	Gene_EXP:SERPINB8	6_69361281_G_A
erk_mapk	Gene_EXP:SERPINE1	1_17240836_G_T,X_156025548_C_T
erk_mapk	Gene_EXP:SFXN3	15_42878595_A_G,15_42952501_A_G
erk_mapk	Gene_EXP:SGCB	17_40035671_A_G
erk_mapk	Gene_EXP:SGCE	5_149320388_T_C,10_46549870_A_G,10_46550021_C_T,10_46550133_C_A,10_46550822_T_C
erk_mapk	Gene_EXP:SGMS1	1_26457907_T_G,22_22643666_C_G
erk_mapk	Gene_EXP:SGPP1	1_153645034_CT_C
erk_mapk	Gene_EXP:SGTB	9_74785802_T_C
erk_mapk	Gene_EXP:SH2B3	1_155661475_T_C,14_64052317_A_G,14_64070939_G_A,19_43359267_G_A
erk_mapk	Gene_EXP:SH2B3	14_21082261_T_G
erk_mapk	Gene_EXP:SH3BGR	19_44985176_A_G
erk_mapk	Gene_EXP:SIAH3	1_26457907_T_G,15_69422319_A_C
erk_mapk	Gene_EXP:SIK1	4_61979670_G_C,12_49752390_C_CT,17_32049442_G_A
erk_mapk	Gene_EXP:SLAIN1	1_26457907_T_G,22_21127217_C_G
erk_mapk	Gene_EXP:SLC19A3	1_26457907_T_G
erk_mapk	Gene_EXP:SLC24A6	19_53237569_T_C,19_53251483_T_C
erk_mapk	Gene_EXP:SLC25A14	3_146194390_T_G,3_151199213_T_G,14_45020416_A_G
erk_mapk	Gene_EXP:SLC26A1	1_237511850_A_AG
erk_mapk	Gene_EXP:SLC30A4	3_39068885_T_TA,3_39078124_T_C,22_39032391_C_G
erk_mapk	Gene_EXP:SLC34A1	2_230498537_TA_T
erk_mapk	Gene_EXP:SLC35D2	7_100996137_C_A,7_100996138_G_A,7_101004057_C_A,7_101004058_G_A
erk_mapk	Gene_EXP:SLC35F1	1_26457907_T_G
erk_mapk	Gene_EXP:SLC37A2	6_70302872_T_C
erk_mapk	Gene_EXP:SLC38A1	7_114653804_G_T
erk_mapk	Gene_EXP:SLC39A13	7_140753336_A_T,17_35259011_T_G,14_21082261_T_G,3_48790461_T_G,11_85724752_T_C
erk_mapk	Gene_EXP:SLC39A3	1_28690201_G_T,16_400140_C_CAG
erk_mapk	Gene_EXP:SLC39A9	19_50977584_C_G,X_52862616_A_G,X_55624568_T_C
erk_mapk	Gene_EXP:SLCO5A1	1_26457907_T_G
erk_mapk	Gene_EXP:SLFN12	1_241723452_T_C,1_241723462_A_G
erk_mapk	Gene_EXP:SLITRK3	1_26457907_T_G,12_52771095_C_G
erk_mapk	Gene_EXP:SLITRK3	8_378251_A_G
erk_mapk	Gene_EXP:SMAP2	3_75665457_C_T
erk_mapk	Gene_EXP:SMC2	15_62657955_G_C
erk_mapk	Gene_EXP:SNAP25	2_71424561_G_GT
erk_mapk	Gene_EXP:SNAPC3	15_71256598_T_C
erk_mapk	Gene_EXP:SNRPG	7_12377736_T_C
erk_mapk	Gene_EXP:SNX29	3_54386725_A_G
erk_mapk	Gene_EXP:SP140L	19_9857463_G_A
erk_mapk	Gene_EXP:SPOPL	5_35876172_A_G
erk_mapk	Gene_EXP:SRSF7	5_181333681_C_T
erk_mapk	Gene_EXP:SSFA2	17_14207114_G_T
erk_mapk	Gene_EXP:SSH3	3_7680310_G_A
erk_mapk	Gene_EXP:ST18	10_133626012_T_A,10_133626013_G_A
erk_mapk	Gene_EXP:STAG2	3_10819431_A_G
erk_mapk	Gene_EXP:STEAP1	17_50677651_A_G
erk_mapk	Gene_EXP:STEAP2	4_25676577_A_G
erk_mapk	Gene_EXP:STYXL1	19_2097371_G_C
erk_mapk	Gene_EXP:SUCLG2	3_160423378_C_T
erk_mapk	Gene_EXP:SYNGR1	1_149055998_GA_G,19_52434956_A_G
erk_mapk	Gene_EXP:TAF3	1_75148689_A_T
erk_mapk	Gene_EXP:TAGLN2	19_10562664_C_T
erk_mapk	Gene_EXP:TBXAS1	1_13104901_G_A,1_13116020_T_C
erk_mapk	Gene_EXP:TEAD3	18_166710_TTAAAA_T,18_166819_T_C,18_264012_G_A
erk_mapk	Gene_EXP:TERF2IP	8_41690230_G_A
erk_mapk	Gene_EXP:TES	4_190026474_T_A,4_190026475_G_A,10_133626013_G_A
erk_mapk	Gene_EXP:TEX30	10_31363289_T_C
erk_mapk	Gene_EXP:TFPI	6_47579334_T_TAA
erk_mapk	Gene_EXP:TGFB1I1	1_149813302_A_C
erk_mapk	Gene_EXP:TGM2	19_2118693_C_T
erk_mapk	Gene_EXP:THAP9	11_62392198_A_C,5_76209739_T_G,20_23990353_G_A,10_102365533_A_G,10_37162765_A_C
erk_mapk	Gene_EXP:THBS1	15_65447029_G_A
erk_mapk	Gene_EXP:THEMIS	6_75240393_TA_T,20_2493490_GA_G
erk_mapk	Gene_EXP:TICAM1	5_50403159_C_A
erk_mapk	Gene_EXP:TIGD3	5_135888024_G_T
erk_mapk	Gene_EXP:TIMELESS	2_218827668_A_C,20_48700966_A_C
erk_mapk	Gene_EXP:TIMP1	19_9985806_C_T
erk_mapk	Gene_EXP:TLN1	6_24595848_C_G
erk_mapk	Gene_EXP:TM4SF19	4_119292875_T_G
erk_mapk	Gene_EXP:TMEM150A	10_88602550_CT_C
erk_mapk	Gene_EXP:TMEM151B	9_67920363_C_T
erk_mapk	Gene_EXP:TMEM173	1_201199371_G_A,1_201200426_T_G
erk_mapk	Gene_EXP:TMEM43	2_230875561_A_G
erk_mapk	Gene_EXP:TMEM64	7_126902472_G_A
erk_mapk	Gene_EXP:TMEM71	8_12358868_A_G,12_20861205_C_G
erk_mapk	Gene_EXP:TMEM74	15_67236036_T_G
erk_mapk	Gene_EXP:TMEM92	8_1565648_A_G,9_61104415_C_T
erk_mapk	Gene_EXP:TMEM9B	1_26457907_T_G,11_120298301_A_C
erk_mapk	Gene_EXP:TMPRSS13	12_110537085_T_C
erk_mapk	Gene_EXP:TMPRSS4	11_18484085_G_A
erk_mapk	Gene_EXP:TNFAIP8	17_16624481_C_A
erk_mapk	Gene_EXP:TNFRSF1A	6_71969190_A_G,15_34381982_T_C,15_34528203_T_C,16_46710765_T_A
erk_mapk	Gene_EXP:TNFRSF1A	11_125747422_A_G
erk_mapk	Gene_EXP:TNIP1	5_154823483_T_G,15_32616231_T_G
erk_mapk	Gene_EXP:TNIP2	7_33099535_G_A
erk_mapk	Gene_EXP:TNS3	7_47967711_A_T
erk_mapk	Gene_EXP:TOM1L1	5_32053643_T_C,11_117136643_A_G,11_117207940_T_C
erk_mapk	Gene_EXP:TOX2	1_116133184_T_G
erk_mapk	Gene_EXP:TP53I11	7_45648634_G_A
erk_mapk	Gene_EXP:TP53I3	12_124966731_T_C
erk_mapk	Gene_EXP:TPCN1	1_240245489_G_A
erk_mapk	Gene_EXP:TPD52L2	9_134036501_T_G
erk_mapk	Gene_EXP:TRIM21	18_50806833_C_G
erk_mapk	Gene_EXP:TRIM26	11_129905704_C_T
erk_mapk	Gene_EXP:TRIP10	14_20381224_T_G
erk_mapk	Gene_EXP:TRIP11	1_230792766_C_G
erk_mapk	Gene_EXP:TRIP6	17_78529677_G_C
erk_mapk	Gene_EXP:TRMT2A	17_76280234_G_A
erk_mapk	Gene_EXP:TSPAN32	2_182063828_G_C,4_147906782_T_C,22_45322160_A_G,9_32472897_A_G,8_22585148_A_G
erk_mapk	Gene_EXP:TSPO	19_53224139_T_C
erk_mapk	Gene_EXP:TSPYL2	2_42288248_A_G,11_33881066_C_A
erk_mapk	Gene_EXP:TSR2	8_109271027_T_C,8_109271124_T_G
erk_mapk	Gene_EXP:TTC1	5_155013898_A_G
erk_mapk	Gene_EXP:TTC17	10_43164088_C_T,11_18534354_C_G
erk_mapk	Gene_EXP:TTC3	12_66128870_G_A
erk_mapk	Gene_EXP:TUBB	1_101786406_G_A
erk_mapk	Gene_EXP:TUBE1	14_68909906_G_A,14_68910058_T_C,14_68910093_G_A
erk_mapk	Gene_EXP:TXLNB	20_56366031_C_T
erk_mapk	Gene_EXP:TXNL4A	11_124397016_A_G
erk_mapk	Gene_EXP:UBA2	22_21634235_C_T
erk_mapk	Gene_EXP:UBA7	21_42543649_A_G
erk_mapk	Gene_EXP:UBAP1	5_31510999_G_T
erk_mapk	Gene_EXP:UBE2H	2_9279286_C_T
erk_mapk	Gene_EXP:USP21	22_22643666_C_G
erk_mapk	Gene_EXP:USP30	5_70495058_G_T,6_57924451_G_T,X_71592597_A_T
erk_mapk	Gene_EXP:USP9X	13_19026335_C_A
erk_mapk	Gene_EXP:VANGL2	6_13182486_T_G
erk_mapk	Gene_EXP:VCL	10_97936313_A_C
erk_mapk	Gene_EXP:VIM	13_99295007_C_T,13_99314037_A_G
erk_mapk	Gene_EXP:VIT	1_176944072_A_T
erk_mapk	Gene_EXP:VPRBP	3_128945112_G_A
erk_mapk	Gene_EXP:VPS37C	3_160416453_CT_C,5_146267624_CT_C,12_15623289_TA_T,13_37746457_TA_T
erk_mapk	Gene_EXP:WASF3	15_67165360_A_G
erk_mapk	Gene_EXP:WDR41	2_217818534_A_G
erk_mapk	Gene_EXP:WFDC2	2_97152499_A_C,2_97152524_G_T,2_97152525_C_G,2_97152527_G_T,2_97152546_G_C
erk_mapk	Gene_EXP:WHAMM	15_59207967_A_G,15_59207979_A_G,15_59207981_C_G,15_59207987_T_C
erk_mapk	Gene_EXP:WIPI1	1_26457907_T_G
erk_mapk	Gene_EXP:WNK3	2_86119057_G_A
erk_mapk	Gene_EXP:WT1	9_33796659_C_T,9_33796705_C_G,9_33798019_A_G
erk_mapk	Gene_EXP:YES1	1_16580833_G_T
erk_mapk	Gene_EXP:ZBTB8OS	10_63177655_C_T,10_63217126_T_G,11_118198037_T_C,19_54632388_T_A,19_54632531_T_C
erk_mapk	Gene_EXP:ZC3H12C	20_18452633_T_G
erk_mapk	Gene_EXP:ZCCHC11	22_36566306_C_G
erk_mapk	Gene_EXP:ZDHHC5	7_101136942_T_G,16_89729370_A_C
erk_mapk	Gene_EXP:ZFHX2	9_27567147_C_T
erk_mapk	Gene_EXP:ZFP82	3_33120406_C_T
erk_mapk	Gene_EXP:ZHX3	7_72926354_C_T
erk_mapk	Gene_EXP:ZMYND11	2_100964113_G_A
erk_mapk	Gene_EXP:ZNF223	8_7564464_G_A
erk_mapk	Gene_EXP:ZNF239	10_35032587_A_C
erk_mapk	Gene_EXP:ZNF250	5_135888024_G_T
erk_mapk	Gene_EXP:ZNF292	20_1445690_A_C,5_141193109_A_G,2_130342165_A_C,10_62069760_A_C,1_89935566_A_C
erk_mapk	Gene_EXP:ZNF292	20_1445690_A_C,2_130342165_A_C,1_89935566_A_C,5_141193109_A_G,10_62069760_A_C
erk_mapk	Gene_EXP:ZNF302	11_87157236_A_T
erk_mapk	Gene_EXP:ZNF331	18_36818951_C_T
erk_mapk	Gene_EXP:ZNF345	1_153772281_T_G,6_53654807_C_T
erk_mapk	Gene_EXP:ZNF420	6_53654807_C_T
erk_mapk	Gene_EXP:ZNF594	19_12433052_A_G
erk_mapk	Gene_EXP:ZNF93	17_47361586_C_T,17_47402080_A_C
erk_mapk	Gene_EXP:ZSCAN16	7_26185482_G_A
erk_mapk	Gene_EXP:ZSCAN18	14_64741308_T_C
erk_mapk	Gene_EXP:ZYX	11_129905704_C_T

[표 21]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value) 및 약물과의 상관도(P-value)를 산출한 결과가 아래 [표 22]에 정리되어있다.

또한, [표 21]에 제시된 FRH들이 포함되어 발현된 유전자들 중 주요 유전자와 각각의 ERK_MAPK 약물과의 상관도(P-value)를 산출한 결과가 도 34에 도시되어 있다.

이들 [표 22] 및 [도 34]로부터 [표 22] 및 [도 34]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 ERK_MAPK 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

DrugPathway	GENE	Variants	Var _Drug( pval )	Var _ Exp ( Pval )
erk_mapk	INHBE_1	chr12_57456335_T_G	5.77E-14	0.023018015
erk_mapk	SMAP1_1	chr6_70773272_G_A	1.18E-08	0.029985176
erk_mapk	SPRY4_1	chr5_142319698_T_G	6.07E-08	0.000420223
erk_mapk	THEM4_1	chr1_151909409_A_C	8.56E-08	0.035981352
erk_mapk	SERPINB1_1	chr6_2837820_C_G	1.44E-07	0.008676416
erk_mapk	EIF2B3_1	chr1_44926782_G_C	7.36E-06	0.00572911
erk_mapk	DUSP6_1	chr12_89350540_G_A	8.18E-06	0.001102792
erk_mapk	TOLLIP_1	chr11_1295591_A_C	1.13E-05	0.041990571
erk_mapk	CDC5L_1	chr6_44387945_G_A	0.000100417	0.000850114
erk_mapk	PAPD7_1	chr5_6746131_C_G	0.000186035	0.046879537
erk_mapk	ABHD2_1	chr15_89199849_C_A	0.000373834	0.002565266
erk_mapk	PLEKHM1_1	chr17_45436185_C_G	0.002692591	0.035787973
erk_mapk	SMC6_1	chr2_17731999_A_C	0.003115924	0.045907596
erk_mapk	RNF38_1	chr9_36400965_C_G	0.004214532	0.007012003
erk_mapk	METTL16_1	chr17_2415256_G_C	0.007239539	0.043637945
erk_mapk	PARP2_5	chr14_20351190_T_A,chr14_20354336_G_T,chr14_20344985_T_C,chr14_20354983_A_C,chr14_20354994_T_C	0.0003461397642250317,0.008144629651779057,1.6511185678613746e-06,9.423861936900617e-06,4.248961897732616e-05	0.0026213592391782425,0.0343587058197046,0.0388723494826529,0.009448771221863612,0.035110640891692815
erk_mapk	CRYL1_6	chr13_20439533_A_G,chr13_20439514_CA_C,chr13_20404113_C_G,chr13_20404176_A_C,chr13_20489466_A_C,chr13_20512438_C_G	0.0007457569282103447,0.04490288969730257,5.4112288097843236e-05,0.0004125161353078136,7.340308839823958e-10,0.0008144017559447111	0.02254568941445808,0.006925654927699,0.014412490268573512,0.0358490969666835,0.0036810252474824734,0.0005690585314639865
erk_mapk	MBD2_2	chr18_54222304_G_C,chr18_54224621_A_C	0.0009174927734817775,0.003370522943374522	0.041746449937120685,0.0024467066581282037
erk_mapk	NUCKS1_3	chr1_205727543_G_A,chr1_205720599_G_C,chr1_205719615_A_C	0.0019226380117114328,5.15182042228384e-07,5.169743185885884e-06	0.007966391204853542,0.0020116543690140926,1.829062095579077e-05
erk_mapk	TMEM8A_4	chr16_377516_T_C,chr16_374277_G_A,chr16_377010_C_T,chr16_375326_T_G	0.0022458300017618115,0.0004991219763661549,0.008152821570691773,0.00033905970470333573	0.02280191742379471,0.008448241096869875,0.02464199505583077,0.03164430214292932
erk_mapk	MCM8_5	chr20_5950428_T_C,chr20_5954739_T_C,chr20_5967525_G_A,chr20_5963301_T_G,chr20_5983067_T_G	0.002650766144390827,0.0020883309843753076,7.538671246466503e-12,0.0005138671174250025,0.00032159758644408336	0.02450503355623649,0.0030061115573713558,0.02006455848870967,0.0209284066776318,0.012878505995892143
erk_mapk	COPS3_3	chr17_17280719_G_T,chr17_17249049_GAA_G,chr17_17280660_A_C	0.0027601645216709264,0.0055818454987667495,0.009754104106729505	0.019538058668087298,0.04875712280071096,0.02319033941785423
erk_mapk	NEDD1_2	chr12_96937308_A_C,chr12_96936634_A_G	0.004287874507177774,0.0016187072229015974	0.019399114812349873,0.02229964139566365
erk_mapk	HDAC6_3	chrX_48803171_T_G,chrX_48817284_T_G,chrX_48817251_CAA_C	0.007173863496387051,0.0004972749557463768,0.0027277691674834114	0.008701773238861378,3.6233113107314475e-06,0.00929153924222002
erk_mapk	MRPL39_6	chr21_25592759_G_A,chr21_25601549_G_T,chr21_25603910_C_T,chr21_25603925_C_T,chr21_25604009_G_A,chr21_25599683_T_C	0.007753577611892022,0.0015571108862256187,0.005054758659783033,0.00740873550689033,0.005591788896050463,0.03750113388472616	0.033844596383331746,0.005711821633941189,0.043198910460816656,0.020407458243495952,0.026357543170222462,0.002961561939886723
erk_mapk	ZBTB8OS_2	chr1_32621836_G_A,chr1_32634036_A_G	0.010623328091650126,0.005807902867508034	0.00035085154745507385,0.001609648081432905
erk_mapk	SNRPC_3	chr6_34767901_T_C,chr6_34767875_CT_C,chr6_34767875_C_CT	0.016258858934554518,0.0255807459946655,0.008409734593854818	0.0021977163744789038,0.005833052025345314,0.047890724740450176
erk_mapk	SH3TC2_5	chr5_149010200_G_A,chr5_149026823_T_C,chr5_149040673_A_C,chr5_149040676_A_C,chr5_149004975_C_T	0.036452606469764885,7.993368579087101e-05,1.313354358475822e-12,1.6742742304793365e-07,3.0188094863269486e-08	0.005163368200425915,0.02459748424962984,0.04603790254373362,0.03254802106345967,0.01898788013634638
erk_mapk	NUP188_7	chr9_128970680_G_T,chr9_128981422_CT_C,chr9_128999694_A_C,chr9_128993243_C_G,chr9_129003287_A_C,chr9_128952722_CAAAA_C,chr9_128981422_CTT_C	0.03889727834709586,5.679744903985549e-07,0.00015792708806478532,0.00011477857081826123,0.006528287639189813,1.3483326927899365e-05,0.001011406252669107	0.006235319995753044,0.0026090470755132837,0.04562376131737803,0.034372383646284414,0.006351306341421021,0.030396670064505107,0.0486576378436576
erk_mapk	PDCD5_2	chr19_32581360_T_C,chr19_32581212_C_G	1.0613555124907784e-06,0.01707686442489131	1.930613826710712e-05,0.00963168433129465
erk_mapk	PCDH1_5	chr5_141865023_A_C,chr5_141864261_A_C,chr5_141864335_T_G,chr5_141854096_T_G,chr5_141864895_A_C	1.146087693284126e-13,2.954523514000492e-06,1.2399540998886776e-05,6.010776449757326e-05,1.3125365237964413e-06	0.00022379266342278662,0.0017861354200376558,0.02539846277902666,0.023845011173266668,0.014684779508972238
erk_mapk	ARL6IP6_3	chr2_152718606_T_G,chr2_152718941_T_G,chr2_152718947_T_G	2.1444201135699293e-06,3.4179740940841686e-10,5.150737082224498e-05	1.916382486428584e-05,0.0014347496711839814,0.0018772601891545288
erk_mapk	TPP1_3	chr11_6616021_T_G,chr11_6619456_A_C,chr11_6616207_T_G	3.898164047661344e-05,6.206193500590457e-06,7.13357999675385e-06	0.03721832122361987,0.0021180587349231865,0.022734527785541702
erk_mapk	SLC35B2_2	chr6_44253096_A_C,chr6_44255584_T_G	4.1264755521968e-08,2.206940612751773e-06	0.045514675788588387,0.0354190738183241
erk_mapk	ETV5_6	chr3_186057145_T_G,chr3_186057158_T_G,chr3_186105591_G_A,chr3_186064432_A_G,chr3_186057367_T_G,chr3_186057421_A_C	4.28224233645744e-14,2.8538105380699127e-12,3.537860306738235e-07,3.53456731728789e-05,8.933112160257351e-07,2.0618345030808515e-05	0.000899440048018852,5.426858809490545e-05,0.008678217049363252,0.012387170842740151,0.01078700094209001,0.04370939373064901
erk_mapk	DUSP4_2	chr8_29340229_A_C,chr8_29337473_A_C	4.4035389796360024e-07,0.0013351841168008725	0.01853773742959819,0.013684370845169195
erk_mapk	ST3GAL4_3	chr11_126408340_T_G,chr11_126406566_A_C,chr11_126424657_A_G	4.582342844339244e-12,1.1939071093750443e-06,6.212889562458534e-09	7.802484819683297e-05,0.006286854884921811,0.03738872157996522
erk_mapk	SKP2_3	chr5_36183922_T_C,chr5_36168236_A_G,chr5_36168246_T_G	4.974059042110084e-09,2.3219549423702208e-12,1.6076332463417848e-08	0.008092624659189506,0.01597032245832584,0.022784487945753537
erk_mapk	GPBP1_3	chr5_57230956_G_A,chr5_57231420_T_C,chr5_57251232_G_A	4.99115882517327e-06,1.8819931578981247e-06,2.491196233571318e-05	0.038048986044057084,0.04556667822911722,0.018325268985280727
erk_mapk	CMTM7_2	chr3_32441841_T_G,chr3_32454197_C_G	5.20316947282785e-11,1.865488768400554e-06	0.022587609002975642,0.027278626571090647
erk_mapk	LRP5_2	chr11_68429633_T_G,chr11_68448944_A_C	8.179359573414423e-10,2.733681134387847e-06	0.01579807768279053,0.024681714140317668
erk_mapk	ETV4_2	chr17_43544973_A_C,chr17_43533230_T_G	8.216801793356959e-07,9.218453009083366e-06	0.025227174262734704,0.0007956602344066278

IGFR 약물에 대한 반응성 바이오 마커

Drug_Class	Gene_exp	바이오마커 ( 발현조절변이세트 )
igfr	Gene_EXP:ABAT	3_51381020_A_G,3_197683305_A_C,16_24930679_T_G,19_18216930_A_C
igfr	Gene_EXP:ACVR1B	1_26457907_T_G
igfr	Gene_EXP:ACVR1B	2_113934259_C_T,5_181155466_T_G,10_79312556_A_G,11_12162199_T_G,12_6818898_A_C
igfr	Gene_EXP:ADAM9	3_165019547_G_T,11_12162199_T_G,10_11921140_T_G,5_181155466_T_G,12_51745916_T_G
igfr	Gene_EXP:ADRB1	1_26457907_T_G
igfr	Gene_EXP:AGBL5	1_224250187_A_G
igfr	Gene_EXP:ANXA1	13_113159942_A_G,16_1817242_T_C,10_11921140_T_G,2_113934259_C_T,5_181155466_T_G
igfr	Gene_EXP:ANXA5	5_181155466_T_G,9_69516199_A_C,12_51745916_T_G,13_113325635_A_G
igfr	Gene_EXP:ASPH	2_105307612_A_C
igfr	Gene_EXP:ATL3	13_113159942_A_G
igfr	Gene_EXP:ATXN7L3B	15_65451964_A_G,2_108507561_T_G,12_57062993_T_G,2_113934259_C_T,5_181155466_T_G
igfr	Gene_EXP:B4GALT1	11_65547388_T_G,13_113159942_A_G
igfr	Gene_EXP:BCL7A	10_11921140_T_G,11_12162199_T_G,13_113159942_A_G
igfr	Gene_EXP:BHLHE41	2_113934259_C_T
igfr	Gene_EXP:BLVRB	15_20566681_C_G
igfr	Gene_EXP:BSN	13_113159942_A_G,16_1817242_T_C
igfr	Gene_EXP:C12orf23	16_72119226_C_G
igfr	Gene_EXP:C12orf29	4_173528913_A_G,10_79312556_A_G,12_40313960_G_T,15_65451964_A_G
igfr	Gene_EXP:C14orf93	20_42084724_T_C
igfr	Gene_EXP:C2orf43	7_108023984_G_A,12_109800676_G_A,19_3281403_A_C,20_42084724_T_C
igfr	Gene_EXP:C2orf44	7_108023984_G_A,7_108024001_C_T,11_65547388_T_G,14_55169342_TAAA_T
igfr	Gene_EXP:CACNA2D2	17_76472531_A_C
igfr	Gene_EXP:CCT2	12_40313960_G_T
igfr	Gene_EXP:CD44	2_113934259_C_T,12_40313960_G_T,12_51745916_T_G,15_75524142_T_C
igfr	Gene_EXP:CELSR1	13_98883961_C_T
igfr	Gene_EXP:CENPV	5_181155466_T_G
igfr	Gene_EXP:CEP68	8_12430448_C_T,13_113159942_A_G,17_55774876_T_G
igfr	Gene_EXP:CIB1	1_149852603_A_G,1_150261398_T_G,13_113159942_A_G,16_1817242_T_C
igfr	Gene_EXP:CLASP2	9_37887606_C_T,16_1817242_T_C
igfr	Gene_EXP:CMPK1	16_18379704_T_G
igfr	Gene_EXP:COQ10B	1_149852603_A_G,13_113159942_A_G
igfr	Gene_EXP:CRABP1	7_72942379_A_C,9_69516199_A_C,12_40313960_G_T
igfr	Gene_EXP:CSRP3	6_33801120_A_G
igfr	Gene_EXP:DAP	12_51745916_T_G
igfr	Gene_EXP:DCLRE1A	1_219979389_T_A
igfr	Gene_EXP:DLG2	1_26457907_T_G,22_18847351_G_C,22_21127217_C_G
igfr	Gene_EXP:DNMT3A	2_113934259_C_T,7_72942379_A_C,11_12162199_T_G
igfr	Gene_EXP:DOK4	13_113159942_A_G
igfr	Gene_EXP:DPP9	22_21127217_C_G
igfr	Gene_EXP:DST	22_22643666_C_G
igfr	Gene_EXP:E2F6	1_248122139_G_T,1_248122185_A_G,12_109800676_G_A
igfr	Gene_EXP:EGFL7	22_22643666_C_G
igfr	Gene_EXP:ELF4	2_108507561_T_G,8_28850143_T_G,13_113159942_A_G,16_30953637_A_C
igfr	Gene_EXP:ELOVL1	9_37887606_C_T,13_113159942_A_G,16_1817242_T_C
igfr	Gene_EXP:ELOVL5	11_12162199_T_G
igfr	Gene_EXP:EML5	19_3281403_A_C
igfr	Gene_EXP:FAM111A	16_1817242_T_C,13_113159942_A_G,2_108507561_T_G,10_11921140_T_G,8_7290003_A_C
igfr	Gene_EXP:FBXO32	11_12162199_T_G,12_40313960_G_T
igfr	Gene_EXP:FBXO41	5_427675_T_C,13_113159942_A_G,16_1817242_T_C
igfr	Gene_EXP:FEV	2_71515762_T_C,2_105307612_A_C,13_113159942_A_G,16_1817242_T_C
igfr	Gene_EXP:GAB2	1_451649_A_AG
igfr	Gene_EXP:GARNL3	12_123632291_G_A
igfr	Gene_EXP:GAS8	13_39724501_TA_T
igfr	Gene_EXP:GATA2	13_113159942_A_G
igfr	Gene_EXP:GBP1	11_12162199_T_G
igfr	Gene_EXP:GDPD1	9_69516199_A_C
igfr	Gene_EXP:GINM1	4_154328181_A_C,7_72942379_A_C,10_73803641_A_G,11_12162199_T_G
igfr	Gene_EXP:GLCCI1	13_113159942_A_G,16_1817242_T_C
igfr	Gene_EXP:GLIS3	2_66439901_A_C,8_7290003_A_C,8_41957277_G_C,10_50311228_T_G,11_65547388_T_G
igfr	Gene_EXP:GPC2	5_141432375_A_C
igfr	Gene_EXP:GTF2H5	3_165019547_G_T,16_15664675_G_T
igfr	Gene_EXP:GTF2IRD1	13_99295924_C_A,16_4823959_A_C
igfr	Gene_EXP:GTF3C2	7_128839939_T_G,7_159142364_T_G
igfr	Gene_EXP:H2AFY2	1_213007133_T_G,10_11921140_T_G,11_12162199_T_G
igfr	Gene_EXP:HEG1	1_54243266_A_G,11_12162199_T_G
igfr	Gene_EXP:HOXD8	20_42084724_T_C
igfr	Gene_EXP:HPCAL4	12_123194624_A_ATT
igfr	Gene_EXP:ICA1	1_451649_A_AG
igfr	Gene_EXP:IL10RB	11_65547388_T_G
igfr	Gene_EXP:IMP4	10_133626801_G_T
igfr	Gene_EXP:IQGAP1	3_128945112_G_A,5_181155466_T_G,8_122952205_T_G,13_113325635_A_G,19_9566733_T_G
igfr	Gene_EXP:JAKMIP2	22_21127217_C_G
igfr	Gene_EXP:JPH1	1_26457907_T_G,19_32643405_T_C
igfr	Gene_EXP:KANK1	11_12162199_T_G
igfr	Gene_EXP:KDELR1	17_62447686_C_T,19_57475779_A_C,X_49304797_C_G
igfr	Gene_EXP:KHDRBS1	5_181155466_T_G,12_6818898_A_C
igfr	Gene_EXP:KIDINS220	1_113549504_C_T,2_113934259_C_T
igfr	Gene_EXP:KIF26A	7_159142364_T_G,10_11921140_T_G
igfr	Gene_EXP:KIF3B	11_1017789_A_C
igfr	Gene_EXP:KLHL18	4_174304301_G_A,13_110205476_C_T
igfr	Gene_EXP:KLHL23	1_26457907_T_G,5_141432375_A_C
igfr	Gene_EXP:LDLRAP1	16_55415_T_G
igfr	Gene_EXP:LRPPRC	11_12162199_T_G,12_40313960_G_T
igfr	Gene_EXP:MAPK8IP2	6_25669441_G_A
igfr	Gene_EXP:MAST1	10_11921140_T_G
igfr	Gene_EXP:MBTD1	2_113934259_C_T,11_65547388_T_G,12_57062993_T_G,15_65451964_A_G,17_55774876_T_G
igfr	Gene_EXP:METAP2	2_208237181_GA_G
igfr	Gene_EXP:MFHAS1	3_132507473_C_CT
igfr	Gene_EXP:MSN	8_7290003_A_C,10_73803641_A_G
igfr	Gene_EXP:MSRA	1_110340768_A_C
igfr	Gene_EXP:MSTN	12_65210914_C_T
igfr	Gene_EXP:MT2A	3_128945112_G_A,15_75524142_T_C,22_42212334_A_C,13_113159942_A_G,10_11921140_T_G
igfr	Gene_EXP:MYRIP	7_36620896_CATGA_C
igfr	Gene_EXP:NCEH1	6_151015603_C_G
igfr	Gene_EXP:NEK6	10_50311228_T_G,11_12162199_T_G,13_39724512_C_T
igfr	Gene_EXP:NFIX	10_101004037_A_C,12_109800676_G_A
igfr	Gene_EXP:NINL	1_26457907_T_G,22_22643666_C_G
igfr	Gene_EXP:NOTCH2	11_65547388_T_G,13_113159942_A_G
igfr	Gene_EXP:NPC1	6_106621398_T_C
igfr	Gene_EXP:NRTN	1_149813302_A_C
igfr	Gene_EXP:OSTM1	11_12162199_T_G
igfr	Gene_EXP:PAIP1	1_112659795_G_A
igfr	Gene_EXP:PHOX2A	12_51745916_T_G
igfr	Gene_EXP:PIP4K2A	X_65956423_C_T
igfr	Gene_EXP:PLAUR	7_72942379_A_C,11_12162199_T_G,12_51745916_T_G
igfr	Gene_EXP:PLEKHF2	7_108023984_G_A
igfr	Gene_EXP:PLIN3	11_12162199_T_G
igfr	Gene_EXP:PLK2	1_26457907_T_G
igfr	Gene_EXP:PLOD2	2_66439901_A_C
igfr	Gene_EXP:PPIC	2_66439901_A_C
igfr	Gene_EXP:PRICKLE2	11_65547388_T_G
igfr	Gene_EXP:PRNP	12_51745916_T_G
igfr	Gene_EXP:PSMB8	8_7290003_A_C,10_11921140_T_G,11_12162199_T_G,X_2856636_A_C
igfr	Gene_EXP:PSMB9	10_11921140_T_G,11_12162199_T_G,16_55415_T_G,X_2856636_A_C
igfr	Gene_EXP:PXDC1	7_159142364_T_G,11_65547388_T_G,13_113159942_A_G
igfr	Gene_EXP:RHBDD2	1_26457907_T_G,22_30937565_T_G
igfr	Gene_EXP:RHOC	1_149852603_A_G,5_181155466_T_G,13_113159942_A_G,17_55774876_T_G
igfr	Gene_EXP:RPL13	20_42084724_T_C
igfr	Gene_EXP:RUFY3	11_65547388_T_G
igfr	Gene_EXP:RUNX2	11_12162199_T_G,15_75268724_T_G
igfr	Gene_EXP:SAT1	12_40313960_G_T
igfr	Gene_EXP:SESN1	8_93815432_A_C
igfr	Gene_EXP:SLC10A3	13_113159942_A_G
igfr	Gene_EXP:SLC25A43	1_54243266_A_G,8_7290003_A_C,19_7627786_T_G
igfr	Gene_EXP:SMARCAD1	6_30705792_T_G,11_65547388_T_G,12_40313960_G_T,15_65451964_A_G,17_55774876_T_G
igfr	Gene_EXP:SMARCB1	3_197683305_A_C,5_80744593_A_C,19_9566733_T_G
igfr	Gene_EXP:SOAT1	2_61492168_C_A,5_38950065_A_T,5_181155466_T_G,12_40313960_G_T,17_51169925_C_T
igfr	Gene_EXP:SOCS1	13_24501721_C_T
igfr	Gene_EXP:SQSTM1	1_26774532_T_C,11_12162199_T_G,13_39724512_C_T
igfr	Gene_EXP:SRSF7	7_108023984_G_A
igfr	Gene_EXP:STAC3	12_65210914_C_T,14_22105305_C_A,15_62835784_G_A,X_299277_G_T
igfr	Gene_EXP:STMN4	13_113159942_A_G,16_1817242_T_C,16_30953637_A_C
igfr	Gene_EXP:STOX2	11_65547388_T_G,13_113159942_A_G,16_1817242_T_C,17_44212322_A_G
igfr	Gene_EXP:SYT4	1_247949628_T_C
igfr	Gene_EXP:TAP1	5_181155466_T_G,8_7290003_A_C,10_11921140_T_G,11_12162199_T_G,20_42084724_T_C
igfr	Gene_EXP:TATDN3	2_87757451_T_TAA
igfr	Gene_EXP:TDRD3	5_154409518_C_G
igfr	Gene_EXP:TEKT2	1_26457907_T_G
igfr	Gene_EXP:TET1	2_188994726_T_G,12_51745916_T_G,15_40767895_T_G,17_55774876_T_G
igfr	Gene_EXP:TFPI	1_213007133_T_G,16_1817242_T_C
igfr	Gene_EXP:TMBIM1	1_208039626_T_G,6_30329265_T_C,17_51169925_C_T,16_55415_T_G,7_72942379_A_C
igfr	Gene_EXP:TMED9	11_12162199_T_G,13_113159942_A_G
igfr	Gene_EXP:TMEM145	10_11921140_T_G,11_34452090_T_G
igfr	Gene_EXP:TPMT	2_61492168_C_A,9_37887606_C_T,11_12162199_T_G
igfr	Gene_EXP:TRMT61B	12_124473081_C_T
igfr	Gene_EXP:TSSC1	2_113934259_C_T
igfr	Gene_EXP:TTC9B	3_128945112_G_A,13_113159942_A_G,16_1817242_T_C,16_30953637_A_C
igfr	Gene_EXP:UBXN7	1_26457907_T_G,22_24252424_G_C
igfr	Gene_EXP:UST	4_70722781_C_T
igfr	Gene_EXP:VPS36	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T,9_33798019_A_G
igfr	Gene_EXP:WASF1	2_108507561_T_G,10_43200831_A_G,16_55415_T_G
igfr	Gene_EXP:WDR35	12_109800676_G_A
igfr	Gene_EXP:WNT5A	11_65547388_T_G
igfr	Gene_EXP:WWOX	22_21127217_C_G
igfr	Gene_EXP:ZBTB34	3_165019547_G_T
igfr	Gene_EXP:ZNF195	2_113934259_C_T,12_40313960_G_T,12_51745916_T_G
igfr	Gene_EXP:ZNF704	11_120836935_C_T
igfr	Gene_EXP:ZNF74	17_55774876_T_G,11_65547388_T_G,5_181155466_T_G,2_113934259_C_T,1_234373536_T_G
igfr	Gene_EXP:ZNFX1	11_125626705_T_G

[표 23]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value) 및 약물과의 상관도(P-value)를 산출한 결과가 아래 [표 24]에 정리되어있다.

또한, [표 23]에 제시된 FRH들이 포함되어 발현된 유전자들 중 주요 유전자와 각각의 IGFR 약물과의 상관도(P-value)를 산출한 결과가 도 35에 도시되어 있다.

이들 [표 24] 및 [도 35]로부터 [표 24] 및 [도 35]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 IGFR 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

DrugPathway	GENE	Variants	Var _Drug( pval )	Var _ Exp ( Pval )
igfr	SEPT6_1	chrX_119618658_T_G	1.08E-09	0.00240717
igfr	EPHA2_1	chr1_16148437_A_C	2.39E-08	0.003022958
igfr	VRK1_1	chr14_96853031_T_G	3.01E-06	0.034233405
igfr	ACTR3_1	chr2_113934245_G_T	4.92E-06	0.01245207
igfr	FOS_1	chr14_75280999_A_C	6.24E-06	0.001488063
igfr	FCHO2_1	chr5_73082876_ATT_A	1.08E-05	0.029256929
igfr	RAC1_1	chr7_6401802_T_G	2.22E-05	0.003141263
igfr	CXCR5_1	chr11_118886492_C_G	6.30E-05	0.044645013
igfr	KCNQ5_1	chr6_72622312_C_G	8.39E-05	0.005821769
igfr	ACSS2_1	chr20_34920910_T_G	8.92E-05	0.038456731
igfr	CRLF3_1	chr17_30792416_T_G	0.000107788	0.014789711
igfr	TSEN34_1	chr19_54192354_T_G	0.000113175	0.001848481
igfr	GTF2IRD1_1	chr7_74512993_A_G	0.000122837	0.006481631
igfr	CECR1_1	chr22_17188516_G_C	0.000127223	0.003052868
igfr	MAP4K1_1	chr19_38617327_T_G	0.000134054	0.013203631
igfr	PAPSS2_1	chr10_87727355_T_G	0.000165034	0.012652487
igfr	LAMC1_1	chr1_183131172_CAA_C	0.000221332	0.002417084
igfr	TBX21_1	chr17_47742656_A_C	0.000232988	0.004538883
igfr	PNRC2_1	chr1_23961703_G_C	0.000287734	0.015853081
igfr	HSPG2_1	chr1_21885485_A_C	0.00029294	0.028105373
igfr	CD72_1	chr9_35610848_A_C	0.000296281	0.049937736
igfr	KLF3_1	chr4_38689006_A_C	0.000348148	0.015121455
igfr	ZNRF3_1	chr22_29048501_A_C	0.000348188	0.024970519
igfr	ASAP2_1	chr2_9399979_T_G	0.000416146	0.021780475
igfr	CCDC69_1	chr5_151185396_T_C	0.000422551	0.005439839
igfr	EPS15_1	chr1_51472751_T_G	0.000562256	0.00454227
igfr	CBR1_1	chr21_36071267_G_C	0.000703843	0.005777456
igfr	CST3_1	chr20_23634133_A_C	0.000813367	0.047435887
igfr	IGF1R_1	chr15_98934682_T_G	0.00081535	0.004668174
igfr	MEI1_1	chr22_41699656_A_C	0.000847426	0.019192604
igfr	PTPN6_1	chr12_6946697_T_C	0.000924277	0.002400753
igfr	PMEPA1_1	chr20_57700062_A_G	0.000939285	0.036764657
igfr	WASL_1	chr7_123692324_GA_G	0.001014849	0.000396379
igfr	ARHGAP15_1	chr2_143228433_T_C	0.001096444	0.039221572
igfr	CLDN12_1	chr7_90413108_T_G	0.00113931	0.004520847
igfr	UACA_1	chr15_70669470_GA_G	0.001211403	0.03571568
igfr	TRIM2_1	chr4_153276097_A_G	0.001260338	0.011894098
igfr	RCC2_1	chr1_17413487_C_A	0.001306044	0.02349276
igfr	CD48_1	chr1_160711863_GA_G	0.001708644	0.04718285
igfr	GLCE_1	chr15_69261053_A_G	0.001722968	0.004293961
igfr	C21orf91_1	chr21_17793434_T_G	0.001758128	0.044828498
igfr	SIGLEC10_1	chr19_51417063_T_G	0.00177184	0.045299996
igfr	NCKAP1_1	chr2_182967372_CA_C	0.001831659	0.004822611
igfr	CD86_1	chr3_122103557_A_C	0.001895858	0.046671667
igfr	ERRFI1_1	chr1_8013331_A_G	0.001920351	0.000188249
igfr	PTPRC_1	chr1_198703381_A_C	0.001955402	0.027037687
igfr	CTDSPL_1	chr3_37957127_T_G	0.002306486	0.04933152
igfr	TAF4B_1	chr18_26286027_C_A	0.00252716	0.005234164
igfr	CDC42BPB_1	chr14_102939620_T_G	0.002756257	4.78E-05
igfr	CTBP2_1	chr10_125026073_A_G	0.002878802	0.03391949
igfr	RASAL3_1	chr19_15458567_G_C	0.003342618	0.038134018
igfr	HLA-DOB_1	chr6_32813293_A_C	0.003408106	0.048853006
igfr	WAS_1	chrX_48691219_A_C	0.00381355	0.02612273
igfr	HBS1L_1	chr6_134965300_CA_C	0.004012929	0.010966837
igfr	FCRL5_1	chr1_157518564_T_C	0.004367637	0.023539142
igfr	UHRF2_1	chr9_6482002_G_T	0.004387102	0.007025127
igfr	SPR_1	chr2_72891611_A_C	0.005381455	0.000101783
igfr	DHX32_1	chr10_125867071_T_C	0.006025442	0.015306739
igfr	DAG1_1	chr3_49531399_T_G	0.006122816	0.000829773
igfr	RAVER2_1	chr1_64768580_T_G	0.007604338	0.049067483
igfr	KIAA0922_1	chr4_153635457_C_T	0.007681106	0.042172485
igfr	ITGAV_1	chr2_186637080_T_G	0.0079744	0.00113911
igfr	MSL3_1	chrX_11772199_A_C	0.00797531	0.040182738
igfr	LAPTM5_1	chr1_30733959_T_C	0.008095451	0.005337526
igfr	TPBG_1	chr6_82364929_T_C	0.009219323	0.003828919
igfr	CD52_1	chr1_26320120_TAA_T	0.009857578	0.041028395
igfr	APOBEC3G_1	chr22_39086265_G_T	0.009915615	0.042244805
igfr	ZNF107_1	chr7_64708051_G_A	0.010400777	0.013846694
igfr	PALLD_1	chr4_168691310_GT_G	0.011706523	0.009714355
igfr	WTAP_1	chr6_159753424_T_G	0.01384856	0.00215073
igfr	HCLS1_1	chr3_121634273_T_G	0.019280657	2.45E-06
igfr	AVPI1_1	chr10_97677649_A_G	0.021081758	0.001581419
igfr	FAM129B_1	chr9_127578987_C_T	0.021421759	0.016089528
igfr	SH3RF1_1	chr4_169096709_G_A	0.024084182	0.008799276
igfr	DR1_1	chr1_93361899_T_A	0.025156433	4.48E-05
igfr	CTTNBP2NL_1	chr1_112457049_C_A	0.028077079	0.00620874
igfr	PPP3CC_1	chr8_22539268_TC_T	0.032546359	0.004572653
igfr	WIPF1_1	chr2_174585550_T_G	0.037854213	0.000483959
igfr	RNGTT_1	chr6_88769645_C_T	0.04013553	0.002545266
igfr	CUEDC1_1	chr17_57873465_G_A	0.046175827	0.009658282
igfr	TMEM106A_2	chr17_43216747_A_C,chr17_43216763_T_C	0.00010599595448116978,0.0011257303404920308	0.0005249300563644175,0.0005036765332449491
igfr	ARHGAP9_2	chr12_57474996_G_A,chr12_57474460_G_A	0.00010627135291362362,0.0006872861852919692	0.036897912823510064,0.04135748735535435
igfr	ARHGAP25_3	chr2_68775067_A_G,chr2_68818005_T_G,chr2_68818023_T_G	0.00011953760418312583,1.4150706205617486e-06,0.0059084060389890105	0.04538887525617117,0.0040433016624282225,0.00032630206809361283
igfr	LMNA_2	chr1_156134461_T_G,chr1_156139242_AT_A	0.00013744315797654898,0.021258069595818274	0.029742625031540286,0.04237931129547261
igfr	DAGLA_2	chr11_61734985_A_C,chr11_61728297_A_C	0.00016688573126791192,8.09952511657234e-05	0.004132304336839055,0.025660366426589504
igfr	NR2F6_2	chr19_17240636_T_G,chr19_17232479_A_C	0.0002005112664246795,0.004658617789678825	0.0007905076911971658,0.04560309985715085
igfr	PLEKHA1_2	chr10_122406608_C_A,chr10_122426897_T_G	0.0002168843436880945,0.005333013480801039	0.013835632948640248,0.02718721223708819
igfr	APP_2	chr21_25881669_T_G,chr21_25881706_A_T	0.00025836883792981226,0.012490170798802495	0.0009005203285702301,0.007363278374314075
igfr	ATP1B1_2	chr1_169127312_A_G,chr1_169131404_A_C	0.0002769045008439269,0.0004647954716516378	0.009381431280957959,0.04764456683437238
igfr	IL10RA_2	chr11_117999603_A_C,chr11_117999569_T_G	0.0003635149788055047,0.002791509228208489	0.033136103226175016,0.042909053419655285
igfr	ERICH1_7	chr8_658279_A_G,chr8_659132_C_G,chr8_659777_T_G,chr8_666991_A_G,chr8_673593_G_A,chr8_659879_A_C,chr8_664843_G_C	0.00036987702944603015,5.389836081615414e-05,0.042347501906470714,0.03423827293146818,0.002457155038695027,0.005217531740497581,0.03193881349739397	0.004174871941240723,0.0054140514901705895,0.007294372779032101,0.0012649483439199085,0.01865482112843118,0.0461414202945825,0.005281332497371782
igfr	ITGB5_4	chr3_124769064_T_G,chr3_124809087_T_G,chr3_124817591_T_G,chr3_124859372_A_C	0.0004279586059829587,0.0005503781084358106,2.8998064871450438e-05,0.007293322508081707	0.0006588536356118503,5.4585187494895796e-05,0.004666117329251896,6.144253538463827e-06
igfr	RFTN1_4	chr3_16357670_G_A,chr3_16369972_C_G,chr3_16433938_A_G,chr3_16316966_A_C	0.0005124144917873522,0.0007740692582134723,0.02739900235302105,1.3310696006188425e-05	0.014764917085914387,4.009218111239421e-08,9.30606513108498e-07,0.008243705342181723
igfr	RBFOX2_4	chr22_35759903_A_G,chr22_35746471_A_C,chr22_35761128_GA_G,chr22_35745982_A_C	0.0005772251529531363,0.0026032665751075587,0.0005990432899641425,0.00370365047461572	0.0021501446732444386,0.003606660377686972,0.04845122900481105,0.009865449869643949
igfr	VSIG10_3	chr12_118095590_T_G,chr12_118073908_T_G,chr12_118095640_G_C	0.0006180518934147943,0.000288504312752602,0.003668316042902092	0.013058144491121623,0.0019761216603789984,0.03443934455659579
igfr	PLEKHG3_2	chr14_64741663_T_G,chr14_64743474_T_G	0.0007814263254356411,0.001157048611523175	5.022222887595109e-05,0.0004341351157000161
igfr	ATP11A_7	chr13_112832759_A_G,chr13_112871823_T_C,chr13_112860417_A_C,chr13_112810736_A_C,chr13_112856140_A_C,chr13_112832768_A_C,chr13_112860332_A_C	0.0007951918344761818,0.0005482830943215422,0.0008173410245384687,0.00028609539850556404,0.0005652380914145368,0.01755140978606275,0.0026211055327575693	0.03593739412008719,0.030074291108272512,0.013638179892540932,0.02325523862538697,0.008605914805152383,0.0022773790348338983,0.006067631423556552
igfr	RUNX3_2	chr1_24907301_T_G,chr1_24907326_T_G	0.0008468237773895464,0.006925491973632575	0.0479402881785652,0.03367486268556343
igfr	CTTN_3	chr11_70419876_A_C,chr11_70419880_T_C,chr11_70407283_C_T	0.000966697322875658,3.5345921815367516e-05,0.005641133258474765	0.00030309409522359497,0.003131141961303907,0.005941149857145408
igfr	CCDC28A_2	chr6_138785343_A_C,chr6_138792859_T_C	0.0013622718680866052,0.005185054082793079	0.011499421256994664,0.046299906365056015
igfr	CD63_3	chr12_55725557_A_C,chr12_55725568_A_C,chr12_55727027_A_C	0.0015370519252913715,4.143328592583745e-05,0.0004442658715243917	0.006833645667760305,0.006277176385590093,0.0005016030317793939
igfr	SCARB2_2	chr4_76179751_A_C,chr4_76179754_T_C	0.0016868597515864868,0.0015619118205883007	0.009508010711643462,0.003674712454161551
igfr	TJP1_4	chr15_29737354_A_C,chr15_29761137_A_C,chr15_29761418_A_C,chr15_29718609_T_G	0.001722668303128766,0.001802650233952311,0.0039948883415691075,0.0004981143114140755	0.03635480241931981,0.005695684405240236,0.0032087876676378537,0.035918560945748516
igfr	CD84_2	chr1_160549875_A_G,chr1_160550877_C_G	0.0018095916002787247,0.0007689474612337844	0.011914227680681896,0.04088607952168802
igfr	IKZF1_3	chr7_50368194_A_C,chr7_50382645_A_C,chr7_50387420_G_C	0.0018105241430139086,0.014707321465940356,0.001698752501804824	0.008403541889994377,0.009343110426337882,0.005840601801883746
igfr	LCP1_3	chr13_46143111_T_C,chr13_46143326_T_G,chr13_46143333_A_T	0.0018838737568387656,0.0030138622548272647,0.002533014213361492	0.004087453394348643,0.0014213406956657436,0.005160539969200112
igfr	FAM177A1_2	chr14_35081207_T_C,chr14_35081218_T_C	0.0021562993680550448,0.0011900365723686852	0.020934419309292008,0.02682119468565008
igfr	WDR91_2	chr7_135211631_T_C,chr7_135187272_A_C	0.0024692334154964657,0.032950442555311085	5.806021129546451e-05,0.006217596359933296
igfr	KLHL6_3	chr3_183492078_A_C,chr3_183508233_G_T,chr3_183508495_A_C	0.0026331756981726236,0.022647868110278375,7.774725762863598e-05	0.03828309904439229,0.005722620392157443,0.025101287121564474
igfr	ZNF543_2	chr19_57329179_A_G,chr19_57328339_A_C	0.002905904571144909,0.0017155256244295665	0.0030296713890405878,0.0008395371531401164
igfr	PLEK_6	chr2_68380987_A_C,chr2_68380990_A_C,chr2_68386526_T_G,chr2_68388306_A_G,chr2_68388311_A_G,chr2_68395610_G_T	0.0029347945425916644,0.002463266314490245,0.0008850637706738338,9.333617954680645e-06,0.0006950651263355477,0.0073361864658662125	0.0018651167043750433,0.004434568689990568,0.0232360676072928,0.012112306050675708,0.028732570109628937,0.04207168924285536
igfr	KDM4C_2	chr9_6990364_G_T,chr9_7103596_C_T	0.0029959320396048127,0.031190087077651845	0.01165227785409256,0.0003043755324224803
igfr	STAG3_6	chr7_100197862_A_C,chr7_100197337_A_T,chr7_100197348_T_C,chr7_100201126_G_C,chr7_100180467_A_G,chr7_100202616_A_T	0.003032352954227882,0.0003006428065929603,0.0015227072304436168,7.395320763427399e-05,2.7805601294277643e-05,0.0008727651283899594	0.0017528283507844654,0.0366941229125814,0.023320205307304158,0.027602097077102532,0.04660308396540184,0.020109594472644786
igfr	WDFY4_2	chr10_48733932_A_G,chr10_48709976_C_T	0.00343399726598083,0.014958425459696244	0.04160917875360734,0.036092320181802036
igfr	PEX3_2	chr6_143462894_AT_A,chr6_143468044_A_T	0.0038068988591272368,0.004816984657632503	0.01772831437707046,0.001265609891969809
igfr	FERMT3_2	chr11_64207498_T_G,chr11_64220073_T_G	0.004734854868796705,0.0003860702269228193	6.601869405274685e-06,0.034308160983635066
igfr	ARHGAP5_3	chr14_32092970_T_C,chr14_32154828_T_C,chr14_32092963_G_C	0.00497062236861118,0.0024371349542205195,0.03352695059876293	0.000109609141495362,0.0028505632724505807,0.007275592799482284
igfr	NGLY1_3	chr3_25733762_T_C,chr3_25736073_G_T,chr3_25732334_A_C	0.0050051985544428655,0.00013354579539043645,0.00040433124284776166	0.0004571643127465467,0.0001003348545752524,0.0008517116761761035
igfr	NCKAP1L_3	chr12_54532103_A_T,chr12_54509948_A_C,chr12_54542688_G_C	0.005115130095563281,0.006142923665719964,0.003395761947631717	0.006178462220094093,0.01506335399115959,0.04657402586559346
igfr	DCK_2	chr4_71023692_C_A,chr4_71022615_CTT_C	0.00551147320732032,0.003204858946259472	0.03456399228988244,0.04731976901534782
igfr	CNOT10_2	chr3_32705030_A_G,chr3_32717271_G_A	0.005986207049477181,0.010027593265925021	0.0007110070373588129,0.0032142136890770555
igfr	ZNF430_2	chr19_21033730_G_A,chr19_21022773_T_G	0.0060011071152059935,0.001269711279469131	3.875366882434858e-05,0.024171318376603662
igfr	DIRC2_2	chr3_122795117_A_C,chr3_122856322_A_G	0.006254194164645703,0.003207873756680403	0.006533610459085206,0.013416690563532
igfr	DENND1C_2	chr19_6469618_A_C,chr19_6466439_T_G	0.0067186287718049645,0.0016600261620732227	0.03949757317188018,0.022653353998851232
igfr	MRPL39_3	chr21_25592788_C_A,chr21_25601549_G_T,chr21_25599683_T_C	0.007244177399862964,0.02581153853071456,0.006446955687932745	0.0040263096113157286,0.005711821633941189,0.002961561939886723
igfr	POLH_2	chr6_43587207_T_G,chr6_43587205_A_G	0.007282790737761695,0.004119102235979657	0.002197498680435875,0.0001905626583652103
igfr	LTBP3_4	chr11_65547976_T_G,chr11_65547974_A_G,chr11_65541348_A_C,chr11_65543270_A_C	0.008230993013661442,0.002905381602762654,3.41563836791927e-05,0.000404704876316852	0.0010020580443514707,0.013780067605462305,0.02423580877660449,0.030868539513201374
igfr	CCND1_2	chr11_69650913_A_G,chr11_69643258_A_C	0.009099246706999426,0.0062885656582625715	0.024298615321604846,0.0008578909246964013
igfr	CTNNA1_4	chr5_138812304_T_G,chr5_138933920_C_T,chr5_138932696_A_G,chr5_138812295_G_A	0.009367597372283164,6.3503870330673816e-06,0.025253708380473885,0.0007665667912501635	0.013339032203366944,0.00010488952235634391,0.007557173168109447,0.014548265287747147
igfr	WDR7_2	chr18_56679573_T_G,chr18_56781547_G_A	0.00936770621562205,0.0029337854053434692	1.7583606026050092e-08,0.0071713352600959014
igfr	RCL1_5	chr9_4844704_T_C,chr9_4844778_A_C,chr9_4849647_T_C,chr9_4860917_G_GT,chr9_4860980_G_A	0.01015934986765833,0.008166765063815772,0.013723578341305795,0.006228375621470136,0.0009546809601140933	0.001687161016128972,0.0053342789487147045,0.004306767506877943,1.3652309819438526e-05,0.014590769537426704
igfr	ZCCHC14_5	chr16_87414470_A_C,chr16_87411666_T_C,chr16_87412604_T_G,chr16_87412609_T_G,chr16_87407905_T_G	0.01093006007749231,0.004904074942282202,0.0043682847900583565,0.00032200703750807235,0.00016922609654741882	0.007871655864135534,0.012673355773035487,0.00292819630706063,0.0093411624607831,0.04674575207321762
igfr	TOM1L1_3	chr17_54937096_G_T,chr17_54937101_G_T,chr17_54947274_A_C	0.011389249245863157,0.02378503173158879,6.37493870407225e-05	0.0005351253630963304,4.7382046214109506e-05,0.0003719570020930906
igfr	SVIL_2	chr10_29532000_A_C,chr10_29486218_G_T	0.014203541816552456,3.6685991514458535e-06	0.005199248570547408,0.02127330473082788
igfr	TEAD4_2	chr12_3019250_C_T,chr12_3022032_A_C	0.02289390603064881,0.0001066489771189534	0.0016254072731388984,0.0001892435681560084
igfr	ARHGAP30_2	chr1_161052161_T_G,chr1_161069551_T_G	0.026797750313656932,0.0002673414213531623	0.0011705834898046734,0.030642225735204174
igfr	FMNL1_3	chr17_45232440_T_G,chr17_45238511_T_G,chr17_45238503_C_G	0.02756877460315332,0.0011473580213809565,0.0021134470829949274	0.006430399709476225,1.3130360508344227e-05,0.014111760701313713
igfr	CD151_3	chr11_836023_C_T,chr11_836227_A_G,chr11_835877_C_T	0.031310628277621426,0.01189492161114428,0.0465236859230004	0.004311678571283407,0.001633994415617101,0.005759250847020773
igfr	MBD2_2	chr18_54204938_G_A,chr18_54224621_A_C	0.032527518290623295,0.02387217907579878	0.007481293790069707,0.0024467066581282037
igfr	ACAP1_2	chr17_7350305_C_T,chr17_7343627_T_G	0.03440244080220003,9.989468867792128e-05	0.009955377908509965,0.02484432576482206
igfr	RHPN2_4	chr19_33002924_G_A,chr19_33044231_A_G,chr19_33044540_A_C,chr19_33011638_C_G	0.03758598191114063,6.498164345874758e-05,0.0019234652198936038,0.0005607094271426628	0.001694407500706198,0.0003445437417821702,0.0007353894363862997,0.0002119158667786005
igfr	RASSF2_3	chr20_4797919_T_G,chr20_4784304_T_C,chr20_4784247_T_G	0.037902749156553485,0.011694257494444695,0.00032929741865870437	0.007153311060028534,0.0020239510039769416,0.0013542591543729706
igfr	MYO1G_4	chr7_44965836_A_C,chr7_44970706_A_C,chr7_44964431_G_T,chr7_44979051_A_C	0.04191223689634028,0.01979144289427551,0.00017645318680118606,0.041733273291402466	0.007221347246269528,0.002699507313002306,0.005180419499391653,0.0010403929060933288
igfr	PIK3CD_4	chr1_9720778_T_G,chr1_9720785_A_G,chr1_9719895_T_G,chr1_9718938_A_G	1.0253516427976307e-05,0.0046476512085552105,0.00011802831952668278,0.006759908616419049	0.0012148539768169404,0.0398063487615097,0.0044497374818740715,0.04703097613769788
igfr	PTGR1_2	chr9_111594107_A_G,chr9_111578959_GAA_G	1.5065359948490627e-06,0.005936401163136037	0.00764869645742515,0.03809849817293055
igfr	SH3D19_3	chr4_151122202_T_C,chr4_151148202_G_T,chr4_151175208_T_G	2.2029420860104835e-05,0.0016057485146252267,0.0049299501495510155	0.00026537095134489047,0.004030165987762314,0.036616308047703286
igfr	DTNBP1_2	chr6_15662698_A_G,chr6_15662701_T_G	2.9366152452741533e-06,0.0006517798782510246	0.0063060334020981846,0.001004314451212422
igfr	ZNRD1_3	chr6_30062280_G_A,chr6_30062358_G_A,chr6_30062412_T_A	3.654974597084793e-05,1.1618445697892011e-05,0.0003334426304369216	0.006713962039550535,0.011500969330972352,0.02821821301850212
igfr	SPATS2L_7	chr2_200329386_C_A,chr2_200412288_CT_C,chr2_200329511_A_C,chr2_200412421_T_G,chr2_200412425_T_G,chr2_200477943_T_G,chr2_200473083_GAA_G	4.207550681496029e-05,0.0004415561732387749,2.0249110903712733e-05,6.324482115669083e-05,0.00042055460201680485,1.4403669192542887e-05,0.007061797305907755	0.0033487592228469143,0.011019446375268936,0.02491924164389806,0.03547678698863923,0.024316311222524558,0.016080388811817628,0.0009052273948575811
igfr	ELOVL5_4	chr6_53295600_A_G,chr6_53295602_T_G,chr6_53291875_T_C,chr6_53291854_T_G	4.333948606334787e-05,9.154580881914281e-06,0.002303807174924029,0.010895023484809672	0.0008036056664569972,0.0007993551420952537,0.0030362229822457412,0.005396507263205953
igfr	AGER_6	chr6_32183680_C_G,chr6_32183336_A_C,chr6_32180626_G_C,chr6_32182537_A_C,chr6_32182532_A_C,chr6_32180983_T_G	4.3474785520824183e-07,0.0008401867950240421,0.00012577188862559035,7.864018103130946e-05,0.0001383347487645318,0.0006412069737516832	0.026487158302874552,0.0008365781303084246,0.018710849801424196,0.024237923466307005,0.005092878554310726,0.028565251544064637
igfr	KLHL18_3	chr3_47319581_T_G,chr3_47344095_C_A,chr3_47319585_T_G	5.8893512793953086e-05,0.003560559459732024,0.0014314792247920815	0.013218876001835087,0.0063137500959640856,0.0442868915202707
igfr	RBM6_6	chr3_50054242_G_T,chr3_50054246_C_T,chr3_50054250_C_T,chr3_50054257_G_T,chr3_50054263_T_G,chr3_50066429_G_T	9.610797412978416e-06,0.0004692267600390496,0.001169115137001947,0.016014825049119413,0.00038946159538077817,6.545113568163317e-06	0.0124136469122058,0.0004024483543288937,3.272618868931358e-05,5.8729619078742086e-05,0.00033057063887385755,0.0016854676901857401

mitosis 약물에 대한 반응성 바이오 마커

Drug_Class	Gene_exp	바이오마커 ( 발현조절변이세트 )
mitosis	Gene_EXP:ACTN2	1_26457907_T_G,22_18847351_G_C,22_21127217_C_G
mitosis	Gene_EXP:ACTR3B	19_5680513_A_C
mitosis	Gene_EXP:ACVR1B	1_26457907_T_G
mitosis	Gene_EXP:ACVR2B	20_10639627_G_A
mitosis	Gene_EXP:ADA	13_113524119_TGTCA_T,13_113510211_T_C,13_113495576_T_C,13_113503637_G_T,13_113539563_C_T
mitosis	Gene_EXP:ADRB1	1_26457907_T_G
mitosis	Gene_EXP:AEBP1	6_72148713_GTT_G,13_24781827_GTT_GT,13_37746457_TAA_TA,20_34750522_TA_T,17_64858885_TA_T
mitosis	Gene_EXP:AKAP7	1_26457907_T_G
mitosis	Gene_EXP:ANO4	9_41294004_C_A
mitosis	Gene_EXP:ARHGAP19	22_22643666_C_G
mitosis	Gene_EXP:ARID1A	7_21862122_CT_C,11_63382198_CA_C
mitosis	Gene_EXP:ARID2	1_26457907_T_G
mitosis	Gene_EXP:AS3MT	7_20786651_GA_G,1_225419673_GA_G,5_95507014_TA_T,9_120989554_CT_C,2_11192112_CT_C
mitosis	Gene_EXP:ATG4A	2_61492168_C_A,2_113934259_C_T,9_35398502_T_G,9_108900415_C_A,16_87644643_G_A
mitosis	Gene_EXP:ATP2B3	1_26457907_T_G,17_7604041_A_C
mitosis	Gene_EXP:ATP6V0A1	11_63382198_CA_C
mitosis	Gene_EXP:ATXN7L3B	15_65451964_A_G,2_108507561_T_G,12_57062993_T_G,2_113934259_C_T,1_213007133_T_G
mitosis	Gene_EXP:BCL11B	1_26457907_T_G,5_141432375_A_C,22_22643666_C_G
mitosis	Gene_EXP:BDKRB1	22_22643666_C_G
mitosis	Gene_EXP:C10orf25	17_39270861_TA_T
mitosis	Gene_EXP:C17orf85	19_54909178_GA_G,1_52789915_CT_C,2_15396385_GA_G,6_7595008_AT_A,9_100450496_GT_G
mitosis	Gene_EXP:C1orf54	8_22080213_T_C
mitosis	Gene_EXP:C8orf33	1_152805392_A_G,1_152805488_G_A
mitosis	Gene_EXP:CARHSP1	13_24781827_GTT_GT,14_68477626_CT_C
mitosis	Gene_EXP:CCDC80	16_53649037_C_T
mitosis	Gene_EXP:CCND3	7_151221500_CT_C,14_68477626_CT_C
mitosis	Gene_EXP:CD44	1_26457907_T_G,1_149813302_A_C,6_151015603_C_G
mitosis	Gene_EXP:CDC42EP3	22_21283300_G_C
mitosis	Gene_EXP:CDK13	1_26457907_T_G,22_30937565_T_G
mitosis	Gene_EXP:CDK2AP2	13_113159942_A_G
mitosis	Gene_EXP:CEBPD	6_150926303_A_G
mitosis	Gene_EXP:CEP85	1_109669334_C_T
mitosis	Gene_EXP:CEP95	11_12162199_T_G,17_55774876_T_G
mitosis	Gene_EXP:CFLAR	5_60605865_GA_G,7_28494789_G_T,9_130489245_A_T
mitosis	Gene_EXP:CIB1	15_25177023_G_C
mitosis	Gene_EXP:CLEC11A	5_179863845_T_G,16_46710765_T_A
mitosis	Gene_EXP:CNTROB	13_97982483_AT_A,2_61498915_TA_T,3_37337179_CT_C,10_70860377_CT_C,5_64507681_TA_T
mitosis	Gene_EXP:CRMP1	1_26457907_T_G,22_21127217_C_G
mitosis	Gene_EXP:CRY1	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T,9_33798019_A_G,19_1057777_GA_G
mitosis	Gene_EXP:CUX2	22_21127217_C_G
mitosis	Gene_EXP:CXCL10	1_15726998_G_A,1_15729869_G_A
mitosis	Gene_EXP:CYP2J2	1_26457907_T_G,5_141432375_A_C,15_42142087_A_C
mitosis	Gene_EXP:CYP4F22	22_21127217_C_G
mitosis	Gene_EXP:DENND4A	7_151221500_CT_C,19_1057777_GA_G,19_51416180_GA_G
mitosis	Gene_EXP:DOCK10	18_76968158_T_C
mitosis	Gene_EXP:DPCD	15_42211755_GA_G
mitosis	Gene_EXP:DPP9	22_21127217_C_G
mitosis	Gene_EXP:DTD1	2_15396385_GA_G,5_77411610_TA_T,10_113620724_G_A,11_63382198_CA_C
mitosis	Gene_EXP:E2F5	8_22080213_T_C
mitosis	Gene_EXP:ELOVL1	1_203683316_A_G,1_203698281_T_C
mitosis	Gene_EXP:ENPP3	1_26457907_T_G,22_22643666_C_G
mitosis	Gene_EXP:EPC1	19_6744459_C_G,19_42723940_A_C
mitosis	Gene_EXP:ESF1	2_231163667_A_C,10_37197397_A_C,11_124877210_T_G,20_26081320_C_T
mitosis	Gene_EXP:EVI2A	1_26457907_T_G
mitosis	Gene_EXP:EVI2B	10_46462341_C_A
mitosis	Gene_EXP:EWSR1	14_68477626_CT_C,17_39270861_TA_T
mitosis	Gene_EXP:FAM114A1	2_217847583_C_T
mitosis	Gene_EXP:FAM69A	4_105679196_A_C
mitosis	Gene_EXP:FANCF	2_61492168_C_A
mitosis	Gene_EXP:FEZF1	1_26457907_T_G,22_22643666_C_G
mitosis	Gene_EXP:FLII	3_52520584_A_C
mitosis	Gene_EXP:FLT3	2_110841381_C_T
mitosis	Gene_EXP:FUCA2	1_26457907_T_G,5_141432375_A_C,22_18847351_G_C,1_219210601_T_G,22_22643666_C_G
mitosis	Gene_EXP:FZD3	1_26457907_T_G
mitosis	Gene_EXP:GBE1	1_26457907_T_G,22_22643666_C_G
mitosis	Gene_EXP:GCNT1	1_26457907_T_G,22_22643666_C_G
mitosis	Gene_EXP:GDPD1	9_69516199_A_C
mitosis	Gene_EXP:GNA15	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T,9_33798019_A_G
mitosis	Gene_EXP:GNAQ	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
mitosis	Gene_EXP:GPC2	5_141432375_A_C
mitosis	Gene_EXP:H2AFY2	22_22643666_C_G
mitosis	Gene_EXP:HEATR5A	4_106236542_TA_T,9_120989554_CT_C,3_9977055_TA_T,7_151221500_CT_C,7_77937691_AT_A
mitosis	Gene_EXP:HIBADH	1_485270_G_A
mitosis	Gene_EXP:HNRNPA0	7_20786651_GA_G,11_33353067_AT_A,20_34750522_TA_T,6_152444591_GA_G,15_42211755_GA_G
mitosis	Gene_EXP:HOOK1	1_26457907_T_G
mitosis	Gene_EXP:HYI	6_99568464_G_C,19_1057777_GA_G,15_34915209_AT_A,15_42211755_GA_G,7_151221500_CT_C
mitosis	Gene_EXP:IFI30	14_77435415_G_GA
mitosis	Gene_EXP:IKBIP	5_141636680_A_C
mitosis	Gene_EXP:IMP4	10_133626801_G_T
mitosis	Gene_EXP:INTS2	20_42084724_T_C
mitosis	Gene_EXP:ITGA3	2_217847583_C_T,2_217847883_G_A,2_217848003_A_G
mitosis	Gene_EXP:JAKMIP2	22_21127217_C_G
mitosis	Gene_EXP:KANSL2	1_26457907_T_G,12_94248247_C_T
mitosis	Gene_EXP:KDM1A	1_53923844_G_GT,1_53966346_G_A
mitosis	Gene_EXP:KDM3B	6_43052450_G_A,6_43054205_C_T,6_43055633_T_C,11_117776746_C_G
mitosis	Gene_EXP:KHSRP	4_119158232_G_A
mitosis	Gene_EXP:KIAA1958	1_26457907_T_G
mitosis	Gene_EXP:KIF15	15_100152748_G_A
mitosis	Gene_EXP:KIF3B	11_1017789_A_C
mitosis	Gene_EXP:KLHL25	3_129433338_GT_G,6_43525297_GT_G,13_97982483_AT_A,6_70861991_TA_T,16_30280420_GA_G
mitosis	Gene_EXP:LGALS1	1_26457907_T_G,11_62825464_G_C,22_22643666_C_G
mitosis	Gene_EXP:LGALS3	1_26457907_T_G,9_83001013_C_A,5_141432375_A_C,1_149813302_A_C,7_100760409_A_C
mitosis	Gene_EXP:LIMS2	6_72148713_GTT_G,11_63382198_CA_C,3_196805277_CT_C,13_24781827_GTT_GT,13_37746457_TAA_TA
mitosis	Gene_EXP:LMBR1L	7_72949311_A_C,12_109266204_T_G,20_35697711_A_C
mitosis	Gene_EXP:LONRF1	1_26457907_T_G,15_42142087_A_C,22_21127217_C_G,22_22643666_C_G
mitosis	Gene_EXP:LPAR6	12_131908770_A_C,X_136033510_GA_G
mitosis	Gene_EXP:LRRC4B	16_3543521_G_A,16_3590476_C_T,16_3606556_G_A,22_21127217_C_G
mitosis	Gene_EXP:MBTD1	2_113934259_C_T,11_65547388_T_G,12_57062993_T_G,15_65451964_A_G,17_55774876_T_G
mitosis	Gene_EXP:MCF2	15_42142087_A_C
mitosis	Gene_EXP:MSL2	5_64507681_TA_T,7_73465568_GA_G,8_73582883_GA_G,13_37746457_TAA_TA,13_37746457_TA_T
mitosis	Gene_EXP:MYH9	1_26457907_T_G,22_21127217_C_G
mitosis	Gene_EXP:MYL9	1_26457907_T_G
mitosis	Gene_EXP:MYOM2	1_26457907_T_G
mitosis	Gene_EXP:NASP	1_109669334_C_T
mitosis	Gene_EXP:NBR2	7_142925619_A_G,7_142944295_A_G,19_3179506_A_C
mitosis	Gene_EXP:NCKAP1L	1_26457907_T_G
mitosis	Gene_EXP:NELL2	1_26457907_T_G,5_141432375_A_C
mitosis	Gene_EXP:NINL	11_33353067_AT_A,13_24781827_GTT_GT,13_37746457_TAA_TA,13_37746457_TA_T
mitosis	Gene_EXP:NNT	10_73696978_G_A
mitosis	Gene_EXP:NPW	1_26457907_T_G,3_52520584_A_C,15_69422319_A_C
mitosis	Gene_EXP:NRIP1	20_2817118_AG_A
mitosis	Gene_EXP:NRM	11_4082830_A_C
mitosis	Gene_EXP:NUDT10	1_26457907_T_G
mitosis	Gene_EXP:NUDT16	1_26457907_T_G
mitosis	Gene_EXP:NUP205	17_7604041_A_C
mitosis	Gene_EXP:PATZ1	17_39270861_TA_T
mitosis	Gene_EXP:PAWR	9_33797971_T_A,9_33797993_G_A,9_33797994_C_T
mitosis	Gene_EXP:PCDH17	1_26457907_T_G,5_141432375_A_C
mitosis	Gene_EXP:PDS5B	19_5654163_A_C
mitosis	Gene_EXP:PELI2	11_63382198_CA_C,13_37746457_TAA_TA,18_21530536_TA_T,6_152444591_GA_G,19_11301321_TA_T
mitosis	Gene_EXP:PIDD	19_7937889_G_A
mitosis	Gene_EXP:PLEKHA4	7_2269556_T_A
mitosis	Gene_EXP:PMP22	22_22117666_G_A,22_22117820_G_A
mitosis	Gene_EXP:POU3F1	1_26457907_T_G,22_22643666_C_G
mitosis	Gene_EXP:POU3F2	1_26457907_T_G,1_205381583_C_G,1_219210601_T_G,3_52520584_A_C,5_141432375_A_C
mitosis	Gene_EXP:POU4F1	X_149503442_T_G
mitosis	Gene_EXP:PPAPDC2	7_44964464_T_C,7_45064532_G_A
mitosis	Gene_EXP:PRKAR2A	13_37746457_TAA_TA,18_74804139_CT_C,13_37746457_TA_T,7_73465568_GA_G,12_107746489_GT_G
mitosis	Gene_EXP:PRKCA	14_39074610_T_TAAG
mitosis	Gene_EXP:PTK7	2_202765379_CT_C
mitosis	Gene_EXP:QSER1	1_15381304_A_C,13_79521022_A_T
mitosis	Gene_EXP:RAB32	1_26457907_T_G,5_141477711_A_G,15_92992967_C_T
mitosis	Gene_EXP:RAB9B	5_133070239_CT_C,11_63382198_CA_C,10_67956845_TA_T,13_37746457_TAA_TA,18_21530536_TA_T
mitosis	Gene_EXP:RAD54L	1_109669334_C_T
mitosis	Gene_EXP:RAP1GAP	1_26457907_T_G
mitosis	Gene_EXP:RAVER2	1_26457907_T_G
mitosis	Gene_EXP:RBM10	6_163478762_CT_C,7_77937691_AT_A,8_108228149_GA_G
mitosis	Gene_EXP:RBM11	1_26457907_T_G,19_624780_A_G,8_109483107_T_G,5_141432375_A_C,12_52771095_C_G
mitosis	Gene_EXP:RBM15B	5_75576972_GA_G,8_73582883_GA_G,10_67956845_TA_T,11_63382198_CA_C
mitosis	Gene_EXP:RBM27	19_48617887_T_G
mitosis	Gene_EXP:RCOR1	1_176702776_TGAGAGAGA_T
mitosis	Gene_EXP:REPS2	1_32780201_C_G,1_32817174_C_A,16_67140459_A_G,16_67146210_G_C
mitosis	Gene_EXP:RHBDD2	1_26457907_T_G,22_30937565_T_G
mitosis	Gene_EXP:RHOC	1_26457907_T_G,5_141432375_A_C,22_22643666_C_G
mitosis	Gene_EXP:RHOC	1_149852603_A_G,5_181155466_T_G,13_113159942_A_G,17_55774876_T_G
mitosis	Gene_EXP:RIPK2	11_63382198_CA_C,6_152444591_GA_G,5_75576972_GA_G,10_67956845_TA_T,5_64507681_TA_T
mitosis	Gene_EXP:RNF219	2_68528704_T_C,10_31363289_T_C,16_60358945_T_C
mitosis	Gene_EXP:RPAIN	10_68691523_T_C
mitosis	Gene_EXP:RPL19	2_61492168_C_A
mitosis	Gene_EXP:RUNX1	9_33796659_C_T,9_33796705_C_G
mitosis	Gene_EXP:RUNX1	1_26457907_T_G
mitosis	Gene_EXP:SEC61G	19_2073455_A_C
mitosis	Gene_EXP:SELRC1	12_40313960_G_T
mitosis	Gene_EXP:SGSM2	2_63842143_GA_G,4_84631729_G_T,7_77256452_A_G,13_97982483_AT_A,16_84054421_T_C
mitosis	Gene_EXP:SIRT4	1_26457907_T_G,11_120298301_A_C,15_89806436_T_G,19_32862451_C_T,19_32864163_A_G
mitosis	Gene_EXP:SLAIN1	1_26457907_T_G,22_21127217_C_G
mitosis	Gene_EXP:SLC25A29	5_70067144_CA_C,7_28494775_GT_G,11_63382198_CA_C,12_25215659_AT_A,21_32744756_GA_G
mitosis	Gene_EXP:SLFN11	1_215675245_T_C
mitosis	Gene_EXP:SMARCE1	6_38951533_A_G
mitosis	Gene_EXP:SNRPB	8_119240272_G_C,12_9165341_A_C,20_36185166_C_G
mitosis	Gene_EXP:SNX3	1_248441636_T_G
mitosis	Gene_EXP:SOX4	6_152444591_GA_G,13_37746457_TAA_TA,17_39270861_TA_T
mitosis	Gene_EXP:SPNS3	9_33796705_C_G
mitosis	Gene_EXP:SRSF1	16_87644643_G_A
mitosis	Gene_EXP:SRSF7	5_181333681_C_T
mitosis	Gene_EXP:SSR3	8_26634739_T_G,16_23445257_T_C
mitosis	Gene_EXP:STAG2	3_10819431_A_G
mitosis	Gene_EXP:STMN1	1_109668049_G_T,1_109669334_C_T
mitosis	Gene_EXP:STOML2	5_154027084_C_T,5_154033830_C_T,5_154053173_T_C
mitosis	Gene_EXP:STOX1	9_67192757_GA_G
mitosis	Gene_EXP:SWT1	1_26457907_T_G,8_109483107_T_G
mitosis	Gene_EXP:SYNC	15_42142087_A_C
mitosis	Gene_EXP:TFCP2	19_55796171_G_T
mitosis	Gene_EXP:TFPI	6_47579334_T_TAA
mitosis	Gene_EXP:TGS1	12_52771095_C_G
mitosis	Gene_EXP:THEM4	2_53919250_GA_G,13_37746457_TAA_TA,18_74804139_CT_C,1_108982799_TA_T,1_74576942_TA_T
mitosis	Gene_EXP:THOC1	1_44804312_T_G,8_68625531_T_G,17_5474687_A_C
mitosis	Gene_EXP:TMEM81	19_7056560_G_T
mitosis	Gene_EXP:TPMT	2_61492168_C_A,9_37887606_C_T,11_12162199_T_G
mitosis	Gene_EXP:TRAM2	1_26457907_T_G,22_21127217_C_G
mitosis	Gene_EXP:TRPM4	1_26457907_T_G,22_21127217_C_G,22_22643666_C_G
mitosis	Gene_EXP:TTF1	8_28850105_GA_G,11_63382198_CA_C,6_152444591_GA_G,7_73465568_GA_G,13_37746457_TAA_TA
mitosis	Gene_EXP:TYMS	9_5557708_T_C
mitosis	Gene_EXP:UBASH3B	14_68477626_CT_C
mitosis	Gene_EXP:UBE2H	2_9279286_C_T
mitosis	Gene_EXP:UBXN7	1_26457907_T_G,22_24252424_G_C
mitosis	Gene_EXP:USF1	1_225419673_GA_G,9_120989554_CT_C,20_34750522_TA_T,6_99369823_GA_G,17_46332538_GT_G
mitosis	Gene_EXP:VAX1	1_26457907_T_G,22_21127217_C_G
mitosis	Gene_EXP:VPS37D	7_72941936_T_C,1_26457907_T_G
mitosis	Gene_EXP:ZC4H2	1_225419673_GA_G,9_120989554_CT_C,13_24781827_GTT_GT,13_37746457_TAA_TA,19_1057777_GA_G
mitosis	Gene_EXP:ZCCHC5	22_22643666_C_G
mitosis	Gene_EXP:ZDHHC17	1_26457907_T_G
mitosis	Gene_EXP:ZDHHC17	1_248638477_A_T
mitosis	Gene_EXP:ZFP82	11_1243593_T_C
mitosis	Gene_EXP:ZNF195	2_113934259_C_T,12_40313960_G_T,12_51745916_T_G
mitosis	Gene_EXP:ZNF22	2_97507111_G_A
mitosis	Gene_EXP:ZNF367	12_48679260_CA_C
mitosis	Gene_EXP:ZNF37A	5_55968325_C_G,17_60426085_G_C,18_6958610_T_C,1_89014072_G_A,2_96841990_T_C
mitosis	Gene_EXP:ZNF445	9_33796659_C_T
mitosis	Gene_EXP:ZNF84	22_46326503_T_C,22_46328661_T_C
mitosis	Gene_EXP:ZNF862	1_26457907_T_G,22_22759034_G_A
mitosis	Gene_EXP:ZSCAN2	2_61492168_C_A

[표 25]에 제시된 FRH 들이 해당 유전자(gene) 발현과의 상관도(P-value) 및 약물과의 상관도(P-value)를 산출한 결과가 아래 [표 26]에 정리되어있다.

또한, [표 25]에 제시된 FRH들이 포함되어 발현된 유전자들 중 주요 유전자와 각각의 MITOSIS 약물과의 상관도(P-value)를 산출한 결과가 도 36에 도시되어 있다.

이들 [표 26] 및 [도 36]로부터 [표 26] 및 [도 36]에 공통적으로 낮은 P-value값을 갖는 유전자(gene)에 포함된 FRH(s)가 MITOSIS 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.

DrugPathway	GENE	Variants	Var _Drug( pval )	Var _ Exp ( Pval )
mitosis	CYR61_1	chr1_85581605_TA_T	5.27E-05	0.000620768
mitosis	MYB_1	chr6_135201764_A_C	0.000110474	0.008038119
mitosis	MYH9_1	chr22_36302635_A_C	0.000236116	0.040823397
mitosis	SNX24_1	chr5_123023772_TA_T	0.00028033	0.010215104
mitosis	CHAF1A_1	chr19_4442532_T_C	0.000284751	0.010330163
mitosis	CASP8AP2_1	chr6_89846678_CT_C	0.000313931	0.000126501
mitosis	MTF2_1	chr1_93137118_TA_T	0.000462823	0.036903175
mitosis	EGFR_1	chr7_55170771_T_G	0.000668389	0.004588325
mitosis	ACVR1_1	chr2_157799371_CA_C	0.000905558	0.016548442
mitosis	MED12_1	chrX_71132797_T_C	0.000941588	0.024279673
mitosis	TRA2B_1	chr3_185921167_T_C	0.001087771	0.003158761
mitosis	CYB5R3_1	chr22_42619486_G_T	0.001094814	0.002582708
mitosis	NFX1_1	chr9_33303208_A_G	0.001100893	0.023431449
mitosis	UACA_1	chr15_70669470_GA_G	0.001412253	0.03571568
mitosis	MOK_1	chr14_102304907_T_C	0.001776612	0.001629205
mitosis	RNF138_1	chr18_32123591_T_C	0.001798779	0.018606829
mitosis	NMT2_1	chr10_15119275_A_C	0.002227268	0.015194231
mitosis	DLG2_1	chr11_83980458_A_G	0.002667354	0.014824348
mitosis	RIN2_1	chr20_19990244_G_A	0.002695061	0.013004393
mitosis	DHX15_1	chr4_24540080_CT_C	0.003782084	0.012007783
mitosis	CD276_1	chr15_73702902_T_G	0.00386155	0.020273648
mitosis	HDAC2_1	chr6_113944423_T_C	0.004344928	0.041935697
mitosis	PIAS4_1	chr19_4039058_G_C	0.005375712	0.037776153
mitosis	ARHGAP15_1	chr2_143216291_G_A	0.005719356	0.035966273
mitosis	STRBP_1	chr9_123266116_C_G	0.006459968	0.001078377
mitosis	MYO1C_1	chr17_1484178_C_T	0.007569353	0.007802374
mitosis	EPB41_1	chr1_29015578_GA_G	0.007616579	0.046541231
mitosis	PRDM2_1	chr1_13823349_T_A	0.00796288	0.011003429
mitosis	MDM4_1	chr1_204536848_GA_G	0.008010095	0.021420681
mitosis	C1R_1	chr12_7091679_A_C	0.00873535	0.0246229
mitosis	RGS16_1	chr1_182600365_T_G	0.009039587	0.036240935
mitosis	KIFC3_1	chr16_57765532_T_G	0.009062011	0.038497261
mitosis	NOTCH2_1	chr1_119922384_T_A	0.009876287	0.022769433
mitosis	PRPF38A_1	chr1_52416794_T_G	0.012365097	0.004382879
mitosis	U2AF1_1	chr21_43093000_GT_G	0.018718881	0.003527509
mitosis	FNDC3B_1	chr3_172328905_GT_G	0.019450759	1.78E-05
mitosis	ITPRIPL1_1	chr2_96325641_T_G	0.024457637	0.004828474
mitosis	PRKCB_1	chr16_24174494_CT_C	0.029704271	0.000670802
mitosis	GMEB1_1	chr1_28702335_T_A	0.031116839	0.003887013
mitosis	IL6ST_1	chr5_55960635_CT_C	0.045023867	0.00567988
mitosis	SRGAP1_1	chr12_64142411_T_C	0.046097342	0.006505853
mitosis	DNMT1_1	chr19_10162649_G_A	0.048749303	0.001347433
mitosis	NPC1_2	chr18_23540944_CT_C,chr18_23539283_G_A	0.00011218638512848764,6.166244499849825e-05	0.040822963170832685,0.020956228007299703
mitosis	KDM2B_2	chr12_121579943_C_CA,chr12_121534367_T_A	0.0002469480356989407,0.00024928370737718086	0.01794421156168876,0.01671856514998881
mitosis	MET_3	chr7_116740945_T_G,chr7_116757685_T_G,chr7_116795676_T_G	0.00037055097855276256,0.003772251227706767,0.04454843008676103	0.00017295700570667475,5.0554093231126755e-05,0.0006156874780574698
mitosis	WWTR1_2	chr3_149669685_C_T,chr3_149669894_G_A	0.0006147608436462098,0.0050779807840600905	0.040303211258058205,0.014886977556994025
mitosis	RPRD2_2	chr1_150470594_A_C,chr1_150473591_C_T	0.0006254084658607492,0.029513176305296374	0.04999439760188915,0.008299610316019734
mitosis	PHIP_9	chr6_78946845_A_T,chr6_78965984_A_G,chr6_78947674_G_A,chr6_78954723_T_C,chr6_78955493_T_A,chr6_78969860_A_G,chr6_78985312_C_T,chr6_78998206_C_T,chr6_79043075_T_C	0.0007025290839441325,0.0008446291153155781,0.010121938819521418,0.017201835088518632,0.014930588444064525,0.02454094082336056,0.009915783788926756,0.0023583595976247713,0.011026610846676282	0.0325055100647953,0.0325055100647953,0.0010048550446085317,0.00648756713202656,0.009594339103514994,0.0017203137452171692,0.0007527047164367361,0.006763071535609179,0.0016364259457283912
mitosis	USP37_2	chr2_218485635_CAAAA_C,chr2_218455538_T_G	0.0008931966771009113,0.00047307780771944745	0.04869664909579453,0.006248282014078397
mitosis	RRAS_3	chr19_49636811_C_T,chr19_49636835_G_A,chr19_49636989_C_A	0.0012180086241795427,0.0008453114718541902,0.00389443225116509	0.011066495702872568,0.008806050890865063,0.010977696307794636
mitosis	SHPRH_7	chr6_145910334_C_A,chr6_145922445_C_T,chr6_145923607_A_G,chr6_145947487_T_A,chr6_145948270_A_C,chr6_145955343_T_G,chr6_145922945_GT_G	0.0015751671472739686,0.008305307007300559,0.003356044877090312,0.00413644978183887,0.009574107378650136,0.0002467850170635296,0.0028322412885894953	0.0007641881109242402,0.0008695206428685066,0.0004025103622500861,0.0002754715942379004,0.020534325332750382,0.0019437040989644704,0.0032085441168495693
mitosis	LAMB2_2	chr3_49132472_A_C,chr3_49126013_T_G	0.0017423458459882547,0.041025181157896495	0.0019625130257961386,0.002569958840604656
mitosis	THRAP3_2	chr1_36288866_G_C,chr1_36282396_ATTT_A	0.0020512788997300887,0.0016248690625818355	0.0001317384338547229,0.04220913139330165
mitosis	CTNNA1_2	chr5_138932696_A_G,chr5_138932714_T_G	0.002692413567981528,0.005472909098268261	0.007557173168109447,0.0016091365079487266
mitosis	TAPT1_2	chr4_16162866_G_A,chr4_16202603_GA_G	0.002918386893883101,0.000914379509289869	0.000763966557961968,0.0004886648390188492
mitosis	SLC35F5_3	chr2_113717856_GA_G,chr2_113742699_CA_C,chr2_113723196_TA_T	0.003014076668232333,0.005012402765669162,0.0170410099009839	0.01701812431912492,6.159712513106605e-06,0.009792441988171948
mitosis	CCAR1_3	chr10_68737016_C_A,chr10_68747145_CT_C,chr10_68760969_CT_C	0.00325467857819848,0.025692165325181263,0.0016743825966123902	0.003954046326130957,0.007417608363424872,0.007417608363424872
mitosis	TADA1_2	chr1_166858437_T_C,chr1_166869276_TA_T	0.003257661220538658,0.007643004397209361	0.012600985482671512,0.00358370659710894
mitosis	SAFB_2	chr19_5668433_GT_G,chr19_5653276_T_G	0.0039066263073592,0.0014480393694902619	0.0026106809691974946,0.018733735357902476
mitosis	LEPROTL1_2	chr8_30105682_AT_A,chr8_30156243_A_C	0.005708636597504029,0.014522072472209685	0.02256500634957293,3.3209275234199355e-06
mitosis	SQSTM1_3	chr5_179833009_G_A,chr5_179822433_T_C,chr5_179832842_G_C	0.005980563650762417,9.139203270628232e-06,0.04751023288058377	0.03979973429187952,0.0024949336391905503,0.0024314650981475784
mitosis	PLEC_10	chr8_143935900_T_G,chr8_143916360_A_G,chr8_143917054_T_G,chr8_143918739_A_C,chr8_143919099_A_G,chr8_143975295_A_G,chr8_143919088_C_G,chr8_143925285_C_T,chr8_143927138_G_A,chr8_143930017_C_T	0.006797512530240399,0.023847093097519808,0.003689478164571844,0.04007075765894598,0.03700251313887589,0.004544202282444686,0.03720602259473315,0.00047050570860322235,4.768364655899894e-05,0.0001893462141118206	0.0004960012901022363,0.00910116635228719,0.025072704488480143,2.138708286444241e-05,0.0010288222361061275,0.039226625991533134,0.009415988048366521,0.005460087145469642,0.008162873576760793,0.001268625363946227
mitosis	CTSA_2	chr20_45893486_C_CT,chr20_45894873_G_C	0.006806775220314732,0.009189197205389115	0.0011092438036515453,2.1137755776974608e-05
mitosis	RND3_2	chr2_150471770_GA_G,chr2_150487464_GA_G	0.006850825677580675,0.002608896214858801	0.004413096667547799,0.009852344084866441
mitosis	DOCK1_3	chr10_127409601_G_A,chr10_127248143_T_C,chr10_127248024_G_T	0.0069346786852210966,0.001954876992257982,0.00010052759289672492	0.021839153568346648,0.030500963727912844,0.020184142497530616
mitosis	MYOF_2	chr10_93341723_C_T,chr10_93379679_T_C	0.007420864833221702,0.007547951219247403	1.0154009952651607e-05,0.0006543495060757152
mitosis	PDS5B_2	chr13_32758091_C_T,chr13_32675925_C_A	0.0075589035603876795,0.0017607048342993868	0.0023301391981286807,0.004241708828197667
mitosis	HEXB_3	chr5_74696784_G_A,chr5_74715459_CT_C,chr5_74715716_T_A	0.007745014587458687,4.786425040147315e-06,8.479985392616748e-06	0.037654298343869685,0.0009700644073606587,0.0006894634360309071
mitosis	TANC1_2	chr2_159136061_C_T,chr2_159174959_G_C	0.00802472531176929,0.006460757964179747	0.017357470848779515,0.02749828370491698
mitosis	ASPH_2	chr8_61642872_G_A,chr8_61638365_TA_T	0.009092096160092012,2.1941312888430133e-05	9.242250914202104e-05,0.0033421074285719613
mitosis	GSN_2	chr9_121326794_T_G,chr9_121318750_T_C	0.009209877230841344,0.005427091425517584	0.014858234163842209,0.01549301533305157
mitosis	ZNF292_3	chr6_87258847_A_G,chr6_87260583_C_G,chr6_87257934_G_C	0.0095880085401273,0.002653056510702511,0.037301685006945806	0.03664575782437445,0.02762172574455939,1.3565314335396872e-05
mitosis	DTNBP1_2	chr6_15662660_G_A,chr6_15651411_GA_G	0.016540725603977957,0.0034858875216863218	0.005994085134454578,0.0014349866138238813
mitosis	SUGP2_2	chr19_19025732_C_T,chr19_19008374_A_C	0.023033529177264773,0.0007995182905667767	0.008182273259557721,0.003040780848236827
mitosis	ARID1B_5	chr6_157084627_G_A,chr6_157084796_G_A,chr6_156935454_GT_G,chr6_156779132_C_G,chr6_157206255_A_C	0.023572130650620228,0.0065953837312734045,0.00024483625735866694,0.0017474661626312965,0.008386743713695547	0.002480449952777213,0.003319459056638543,0.031030935390966245,0.0436791475273224,0.02302848816217332
mitosis	DAZAP1_3	chr19_1432575_T_C,chr19_1432578_A_C,chr19_1421326_T_G	0.025717426655995912,0.012380456372647609,0.005697517435006497	0.008783799588482919,0.004625103934387489,0.03399063425366008
mitosis	FAM76B_2	chr11_95786079_T_C,chr11_95787545_T_C	0.026712661661121014,0.007093482411673812	0.008842917440325095,0.006738523037696958
mitosis	CNTRL_3	chr9_121175323_T_C,chr9_121167492_C_T,chr9_121123912_AT_A	0.02777922136116125,0.03429035595633583,0.009987376618823514	0.008182636643218607,0.0016137010941682265,0.04001035208622377
mitosis	IQCB1_4	chr3_121788384_A_T,chr3_121807190_T_G,chr3_121781663_A_T,chr3_121781662_C_A	0.02873631298848243,0.04311975747619515,0.0034541658078948746,0.0008249500332497977	0.0011523884052119758,0.0035712731344638405,0.03680371502100786,0.031208890653500118
mitosis	RRBP1_2	chr20_17636886_T_C,chr20_17643440_G_A	0.03507251839152679,0.01991260739356573	1.9056892828600246e-06,0.0037236305333221867
mitosis	ZNF84_2	chr12_133048690_A_T,chr12_133048009_C_G	0.037210990330289934,0.040160599243354515	0.0028259388562976405,0.008314464537214374
mitosis	MYCBP2_2	chr13_77098982_T_G,chr13_77061586_T_C	0.03744183774757608,0.00310540257860121	0.0038229074053839733,0.030373685856290068
mitosis	CALD1_3	chr7_134933124_A_G,chr7_134891710_CTT_C,chr7_134941283_GAAA_G	1.0681523332046643e-06,0.0055155972985149685,0.0008159520917689481	0.034156156662500686,0.006749784168432884,0.007042501841739691
mitosis	RBMX_5	chrX_136874303_G_C,chrX_136874308_C_T,chrX_136876571_C_A,chrX_136880660_G_A,chrX_136879426_ATG_A	5.449363562924237e-05,3.4887046700057416e-07,6.172396284131506e-05,0.0054727241117358974,0.005573036956662709	0.0383480406291467,0.029837740684056712,0.015245783387880662,0.03540981223032282,0.0056729536604581
mitosis	POLR2B_3	chr4_57005538_CA_C,chr4_57023798_AT_A,chr4_57024870_CT_C	5.482928793734288e-06,0.02167722586394588,0.0009543180256774695	0.018564114826717992,0.007472844031288456,0.0012756499136273938
mitosis	SECISBP2_3	chr9_89319872_A_G,chr9_89325866_A_T,chr9_89348180_T_G	6.195560569127674e-05,0.0006584940331716795,0.0021577193257759702	0.020014055406942226,0.00642217291639139,0.01739212501206905
mitosis	FBXO41_2	chr2_73258961_C_G,chr2_73264474_A_C	7.08184621839895e-05,0.008886058285019023	0.010646018841909207,0.014910469893708134
mitosis	TSPAN4_2	chr11_844057_C_G,chr11_865650_C_G	8.251559449584364e-05,0.0042898689776822594	0.04166717005266338,0.02401170518473186

한편, 도 23에는 [표 1]에서 정리한 6개 암타입과 [표 14]에서 정리한 6개 약물타입에 대한 약물의 동반진단을 위한 바이오마커 검출에 사용되는 검사칩을 제작하는 방법이 도시되어 있다.

도 23에 도시된 바와 같이, 제1단계에서, [표 1] 및 [표 14]에 특정된 암타입 및 약물타입에 대한 각 바이오마커들에 대한 진단칩을 제작하거나, 상기 암타입 및 약물타입에 대한 모든 바이오마커만들거나 혹은 전체 을 모두 하나의 칩을 제작하고, 환자로부터 약물타입 또는 암타입과 관련된 FRH 마커에 대하여, 도 18의 도시된 실시예(혈액암의 약물타입 중의 하나인 EGFR pathway) 약물반응과 연관이 높은 한 세트의 FRH 및 특정암에 연관성이 높은 전체 FRH를 사용하여, 도 20의 Linear Regression 예측모델을 생성하는 형식으로 약물반응성을 예측할 수 있다. 따라서, 본 특허에서 정리한 12개 암타입(CancerClass) 및 18개 약물타입(DrugClass)에 특이한 FRH 바이오마커들을 이용하여 다양한 암 및 암약물 동반진단 칩을 도 23처럼 제작하여 활용할 수 있다.

최종적으로, 본 발명을 요약하면, 본 발명은 기능 하플로타입 정보를 활용하여 약물반응성 예측 모델을 계산하기 위해, 검사 대상 유전체로부터 수집된 염기서열에서 다수의 변이들을 활용하여 기능 하플로타입 들을 계산하는 단계와: 기능 하플로타입과 약물반응성 정보간의 선형 회귀 모델의 해를 계산하는 단계와; 이러한 해를 이용하여 효과적으로 암 약물 중에 민감성이 높은 암 약물을 필터링하는 가상임상(In Silico Clinical Trial)을 위한 약물 반응성 예측 방법에 관한 것이다.

용어의 설명

본 발명에서 약물타입(DrugClass)에 대한 정의는 약물 표적들의 타입(type) 및 약물의 관능기적 유사한 기능 타입, 혹은, 약물이 영향을 주는 범주의 유전자그룹, 약물 패스웨이(drug pathway) 혹은 약물 시그널링 패스웨이(drug signaling pathway), 등은 모두 하나의 통칭 약물타입(DrugClass)로 설명 하는 용어이다. FRH는 기능하프로타입(functionally related relative haplotype)을 나타내는 용어이고, eQTL은 발현에 대한 양적형질위치 (expression quantitative trait loci)을 나타내는 용어이며, FRH(Exp|IC50)는 과/저(over/under) 발현된 군집에 대한 IC50의 평균값을 나타내는 용어이고, FRH(CNV|IC50)는 증폭/삭제(amplification/deletion) 군집에 대한 IC50의 평균값을 나타내는 용어이며, FRH(loci|IC50)는 주어딘 loci타입 군집에 대한 IC50의 평균값을 나타내는 용어이고, GDSC는 Genomics of Drug Sensitivity in Cancer을 나타내는 용어이며, CCLP는 COSMIC Cell Lines Project을 나타내는 용어로 웹페이지 http://cancer.sanger.ac.uk/cell_lines로부터 확인할 수 있고, CNV는 복제수변이(Copy number variation)을 나타내는 용어이며, GBLscan는 암동반진단마커 스켄(Cancer Biomarker Labeling Scan)을 나타내는 용어이고, ISCT는 가상임상(In Silico Clinical Trial)을 나타내는 용어이다.

본 발명의 권리는 위에서 설명된 실시예에 한정되지 않고 청구범위에 기재된 바에 의해 정의되며, 본 발명의 분야에서 통상의 지식을 가진 자가 청구범위에 기재된 권리범위 내에서 다양한 변형과 개작을 할 수 있다는 것은 자명하다.

본 발명은 암을 포함하는 질병 관련 특이 유전자 변이 지문 (Genetic Variation Fingerprints)과 약물의 분자 약리관능기의 결합분석에 의해 약물의 반응성을 신뢰성 있게 예측할 수 있는 새로운 선형 회귀 모델인 약물 적응증 및 반응 예측 시스템 및 방법인 GBLscan (Genetic Biomarker Scan)에 관한 것으로, 본 발명에 의하면, 본 발명에서는 체외 및 체내 임상시험으로부터 수집되는 유전체에 대한 약물의 반응성 결과들로부터, 약리 효과가 밝혀지지 않은 유전체와 약물의 반응성 정도를 예측할 수 있는 효과가 있다.

Claims (1)

1. 혈액암 약물에 대한 반응성 판단을 위하여,
   [표 2]에 기재된 마커 중 어느 하나 이상을 포함하여 구성됨을 특징으로 하는 암 약물 반응성 판단을 위한 바이오 마커.
   

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