KR20200054857A - Egfr 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 egfr 약물 반응성 판단 방법 및 egfr 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 - Google Patents

Egfr 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 egfr 약물 반응성 판단 방법 및 egfr 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 Download PDF

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KR20200054857A
KR20200054857A KR1020190098569A KR20190098569A KR20200054857A KR 20200054857 A KR20200054857 A KR 20200054857A KR 1020190098569 A KR1020190098569 A KR 1020190098569A KR 20190098569 A KR20190098569 A KR 20190098569A KR 20200054857 A KR20200054857 A KR 20200054857A
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Abstract

본 발명은 EGFR약물 반응성 기능 정보를 포함하는 하플로타입(haplotype) 바이오마커를 예측하여, EGFR 약물 반응성을 신뢰성 있게 예측 및 약 레이블링을 할 수 있게 하는 새로운 학습 모델인 GBLscan (Cancer Biomarker Labeling Scan)을 이용한 EGFR 약물 반응성 판단을 위한 바이오 마커 조성물에 관한 것으로, 본 발명은 EGFR 약물에 대한 반응성 판단을 위하여, 유전자 발현을 조절하는 변이가 포함된 마커들의 조합으로 구성되는 바이오 마커 조성물에 있어서, 상기 바이오 마커 조성물은, 9_111597344_C_A(마커1) 및 18_47115026_C_T(마커2)를 포함하여 구성된다. 이와 같은 본 발명에 의하면, 본 발명에서는 EGFR 관련 약물들에 대한 바이오 마커들을 통해, EGFR 약물에 대하여, 대상자 유전형질별 민감성을 예측할 수 있으므로, 개인별 맞춤의학 분야뿐만 아니라 신약 후보군 발굴에 효과적인 예비검증이 이루어지도록 하는 효과가 있다.

Description

EGFR 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 EGFR 약물 반응성 판단 방법 및 EGFR 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 { Bio-Marker Composition for Sensitivity Prediction of EGFR Drug, Estimation Method for Sensitivity Prediction of EGFR Drug using Bio-Marker Composition and Diagnosing Chip for Detection of Bio-Marker Composition for Sensitivity Prediction of EGFR Drug }
본 발명은 EGFR 암약물의 반응성을 예측하기 위한 유전자발현정보 및 복제수변이(CNV)를 이용한 기능 정보를 포함하는 하플로타입(haplotype) 바이오마커에 관한 것으로, EGFR 약물 반응성을 신뢰성 있게 예측할 수 있도록 하는 EGFR 약물 반응성 판단을 위한 바이오 마커 조성물에 관한 것이다.
최근에 차세대시퀀싱 (NGS, next generation sequencing) 기술의 혁신으로 복잡하고 다양한 암을 이해하는데 많은 발전이 이루어졌다. 또한, 국제적인 컨소시엄의 노력으로 이러한 암 종의 체세포 돌연변이에 대한 카탈로그뿐만 아니라 총체적인 암 유발 돌연변이(driver mutation) 데이터베이스도 개발 및 발표되었다[선행기술문헌 001 참조].
이러한 국제적인 컨소시엄 연구 성과로 인해서 개별 종양의 특정 유전체 지문(genomic fingerprint)에 대한 암 맞춤치료에 대한기대 또한 급속도로 커지게 되었다.
그러나 현재 암 환자 및 제약업계를 포함한 의료계의 모든 이해 관계자들에게 임상에서 승인되고 사용되는 새로운 맞춤 암 치료제는 여전히 충분하지 않은 실정이다[선행기술문헌 002 참조]. 따라서, 유전체정보와 항암제의 반응 사이의 개인 맞춤을 위한 연관성을 예측하기 위한 효율적이고 체계적인 접근이 필요하게 되었다.
그리고 암 세포주 및 약물 독성 데이터의 분자 프로파일링 데이터를 통합하기 위해 여러 가지 협력 컨소시엄이 이루어졌다[www.lincsproject.org, 선행기술문헌 003 참조]. 이러한 컨소시엄은 항암제 독성 및 개인에 특화된 맞춤 약물을 예측할 수 있는 유전체 바이오마커 (biomarker)를 밝히는 것이 가장 중요한 목표이다.
암에서의 약물 독성을 위한 세포주 유전체 DB중에서 GDSC (GDSC, Genomics of Drug Sensitivity in Cancer)는 공개적으로 이용 가능한 데이터베이스의 한 예이다. 특히, GDSC는 265개의 항암 화합물에 대하여 1,070 개의 인간 암세포의 약물 독성 정보를 실험적으로 측정한 공용 데이터베이스이다[선행기술문헌 004 참조].
여기서 사용된 GDSC의 세포주 프로젝트는 다음의 사이트에서 공개되었다 (CCLP: COSMIC Cell Lines Project, http://cancer.sanger.ac.uk/cell_lines). 이러한 공용 자원은 유전체 기반 정밀 암 치료제 실현에 큰 도움이 될것으로 기대된다.
그러나 이러한 데이터베이스의 잠재적인 가치에도 불구하고 높은 차원의 데이터와 복잡성으로 인해 통합 분석에는 많은 기술적인 문제가 존재한다. 따라서, 항암 약물 독성에서 분자 바이오마커를 체계적으로 규명하기 위한 많은 계산방법이 개발되었지만[선행기술문헌 003 참조], 이러한 노력에도 불구하고 약물 독성은 특정 세포주 및 주어진 유전자 변이 세트에 제한되는데, 이는 모든 사람의 유전정보는 모두 다르고, 공통적인 변이는 전체에서 일부분이기 때문이다.
정보 기술의 최근 발전으로 앞에서 언급한 복잡한 문제를 해결하기 위해 점점 더 많이 사용되는 방법이 딥러닝 모델(deep learning model) 또는 심층학습 모델이라 부른다[선행기술문헌 005 참조]. 딥러닝 학습 방법은 대량의 고차원 원시 데이터로부터 심층 기계 학습을 하는 기술의 한 분야이다.
최근까지는 학습을 하기에 계산 양의 한계로 직접적으로 많은 제한이 있었지만, 그러나 방법론적 개선과 병렬 컴퓨팅에 의한 강력한 기계를 사용하면서 수천 개의 숨겨진 유닛을 포함하는 다양한 레이어로 딥러닝 학습 모델을 교육할 수 있게 되었다[선행기술문헌 006 참조].
한편, 약리적, 유전체, 전사체 및 후성유전체 데이터와 그들의 약물반응성 데이터와 같은 여러 유형의 구조 정보를 조작할 수 있기 때문에 최소한의 지침으로 약물-표적 상호 작용 예측에 적합하게 되었다[선행기술문헌 005 참조].
제약 업계는 신약 개발을 위해 이러한 유형의 데이터를 활용하는 딥러닝 학습에 많은 기대감을 보여주기 시작했다. 최근에는 약물 개발에서 인공 지능을 사용하여 몇 가지 유망한 결과가 입증되었고[선행기술문헌 007 참조], 약물-표적 프로파일 및 다른 전통적인 기계 학습 모델에 비해 우수한 예측 정확도를 갖는 약물 재사용(drug repositioning)도 가능해졌다. 그러나 대다수의 접근방법은 오히려 개념 증명에 그쳤고, 딥러닝 학습을 통한 약물 발견의 생산 가능 솔루션은 부족한 현실이다.
현재 PubChem(pubchem.ncbi.nlm.nih.gov)은 미국 NCBI(국립기술정보센터)에서 운영하고 있고, 약 1억개 화합물(compounds), 2억 개의 물질(substances) 및 바이오에세이(bioassay)정보를 보유하고 있다(en.wikipedia.org/wiki/PubChem).
또한, 이러한 화합물(compound)은 약리적 작용기(pharmacophore descriptor)로 표현하는 많은 방법들이 존재한다[선행기술문헌 008 참조]. 그 중에서 파델(PaDELL) 방법은 약물에서 1,875 (1D 및 2D 1,444개, 그리고 3D 431개) 특징(feature) 및 12개의 지문(전체 약 16,092 비트)으로 표현할 수 있다[선행기술문헌 008 참조].
그리고 유전체에서 변이는 다양한 특징들을 추출할 수 있다. 특히, 질병원인 변이를 추출하는 종래의 방법들은 다양한 문헌에 개시된 바 있다.
따라서, 종래기술은 개별적으로 QSAR(Quantitative structureactivity relationship), 약물 세포독성 데이터를 사용한 약물개발, 딥러닝 (Deep Learning)기반 전장유전체(whole genome sequencing)의 발현조절, 구조적 변이 등이 독립적으로 적용되어 활용되었다.
그러나 본 발명에서는 약물(drugs)-세포(cell lines)-독성(IC50) 데이터에 이종 특성정보(유전체정보, QSAR정보 및 발현정보)를 통합한 AI 딥러닝 방법인 CDRscan(Cancer drug response scanning)은 예측 정확도가 이전 컴퓨터 모델링 접근법과 비교하여 현저히 향상되었고, 특히, 버추얼 약물(drugs) vs. 버추얼 세포(cell lines) 혹은 표적단백질의 상호작용 모델을 제안한 바 있다.
여기서, 2개의 다른 이종 특성 버추얼 정보는 첫 번째가 약물인 경우, 파델(PaDELL) 방법 혹은 선행기술문헌 029 내지 033에 개시된 방법 들이 적용될 수 있다.
그리고 두 번째는 전장 유전체(혹은 표적 단백질)의 지문(Genomic fingerprint, or a set of mutation features)에 대한 문헌방법으로 설명이 될 수 있고, 가장 표준적인 딥러닝 방법은 선행기술문헌 009에 개시된 바와 같다.
따라서 본 방법은 정확한 약물반응 예측모델 및 약물 재사용/재배치(drug repositioning), 화학 물질의 스크리닝 및 새로운 항암제 후보 발굴 및 환자 맞춤형 항암제 선택을 위한 임상의사결정지원시스템(Clinical decision supporting system) 에 사용될 수 있다.
그리고 최근에 재사용/재배치 (drug repositioning)관련 암약물반응스켄(CDRscan) 논문이 본사에 의하여 출판이 되었다[선행기술문헌 010 참조].
즉, 유전자발현 및 시스템적 통계적인 방식으로 주어진 약물 및 표적유전자 약 그리고 표적 후보유전자들의 발현정보 및 바이오마커 정보를 활용한 약물반응성 연구가 최근에 발표되었다.
본 논문에서는 바이오마커 자체에 대한 연구는 없었지만, 알려진 유전자 바이오마커 및 발현정보를 활용하여 주요표적에 대한 주요 약물 몇 개에 대하여 저해 능력(inhibition)을 CCLE(Cancer Cell Line Encyclopedia), CTRP(Cancer Therapeutics Response Portal, Broad) 및 일부 GDSC를 활용하여 예측(CARE)하고 검증하는 결과를 보여주었다[선행기술문헌 011 참조].
또한, eQTL (expression and Quantitative Trait Loci), 즉 발현과 유전체 변이간의 질병 혹은 표현형 연관관계에 대한 주요 연구가 많이 발표되었다[선행기술문헌 012 참조]. 그리고, pQTL (protein and Quantitative Trait Loci), 즉 단백질 생성과 유전체 변이간의 질병 혹은 표현형 연관관계에 대한 주요 연구 역시 많이 발표되었다[선행기술문헌 013 참조].
그러나 cQTL (Copy Number Variation and Quantitative Trait Loci), 즉 약물반응성 및 유전자 복제수 증가 혹은 감소 변이인 CNV(copy number variation)와 유전체 변이간의 약물반응 혹은 약물 표현형 연관관계에 대한 연구는 아직까지 발표된 적이 없다.
따라서, 본 GBLscan(genetic biomarker label scan)방법에서는 (a) eQTL (expression and Quantitative Trait Loci), 즉 발현과 유전체 변이간의 질병 혹은 표현형 연관관계, (b) cQTL (Copy Number Variation and Quantitative Trait Loci), 즉 유전자 복제 수 변이(copy amplification) 및 감소 (copy deletion)과의 연관관계는 아직 참고문헌이 존재하지 않는다.
본 발명에서 약물타입(DrugClass)에 대한 정의는 약물 표적들의 타입(type) 및 약물의 관능기적 유사한 기능 타입, 혹은, 약물이 영향을 주는 범주의 유전자그룹, 약물 패스웨이(drug pathway) 혹은 약물 시그널링 패스웨이(drug signaling pathway), 등은 모두 하나의 통칭 약물타입(DrugClass)로 설명을 한다. 또한, 기능하플로타입은 일반적으로 사용하는 하플로타입인 유전자에서 페이싱(phasing)이 된 여러개의 로커스 (locus)들에 대한 반수체(haplotype)과 달리, 본 발명에서는 인간유전체 버전인 Dec. 2013 (GRCh38/hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https ://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 를 기반으로 차세대 시퀀싱 리드(read) 데이터를 정렬을 하게 되면, 각 유전자 로커스에서 지노타입 형태로 정보가 읽히게 된다. 이러한 지노타입형태는 1:homo, 2:hetero 혹은 3: alt home형태로 표현 되는데, 그러한 지노타입의 모음을 상대 하프로타입 이라고 할 수 있다. 그리고 특정 로커스의 단일 혹은 조합으로 구성된 상대 하플로타입이 특정 유전자의 발현과 연관이 있다면 이것을 기능하프로타입이라고 본 발명에서 정의한다.
한편, 아래 첨부된 비 특허 선행기술 문헌을 주요 내용별로 구분하면, 비특허문헌,
(001 - 002)은 유전체 정보와 항암제의 반응 사이의 연관성 논문이고;
(003 - 004)은 암 유전체 약물독성 및 COSMIC 세포주 프로젝트 문헌이며;
(005 - 006)은 딥러닝 심층학습 모델의 약리학 및 유전체관련 논문이고;
(007)은 딥러닝 심층학습 모델의 신약 개발에 사용된 논문이고;
(008)은 약물 및 변이를 특징(feature)으로 표현하는 방법 및 논문이고;
(009 - 010)은 딥러닝 방법론 및 알고리즘에 대한 논문이고;
(011)은 약물 재창출 혹은 약물반응성 예측 논문이고,
(012 - 013)은 eQTL 및 pQTL 방법론 및 알고리즘에 대한 논문이다.
(001) Forbes, S. A., et al. COSMIC: somatic cancer genetics at high-resolution. Nucleic Acids Research. 45, 777-783 (2017). (002) Williams SP, & McDermott U. The pursuit of therapeutic biomarkers with high-throughput cancer cell drug screens. Cell Chemical Biology. 24, 1066-1074 (2017). (003) Barretina, J, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 483, 603-7 (2012). (004) Yang, W., et al. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Research. 41, 955-961 (2013). (005) Vanhaelen, Q., et al.. Design of efficient computational workflows for in silico drug repurposing. Drug Discovery Today. 22, 210-222 (2017). (006) Dahl, G. E., Jaitly, N. & Salakhutdinov, R. Multi-task neural networks for QSAR predictions. arXiv:1406.1231 (2014). (007) Baskin, I.I., Winkler, D. & Tetko, I.V. A renaissance of neural networks in drug discovery. Expert Opinion on Drug Discovery. 11, 785-95 (2016). (008) Yap CW. PaDEL-Descriptor: An open source software to calculate molecular descriptors and fingerprints. Journal of Computational Chemistry. 32, 1466-1474(2011) (009) Deep Learning: Yann Lecun, Y., Bengio, Y. & Hinton, G. Nature. 521, 436-444 (2015) (010) Cancer Drug Response Profile scan (CDRscan): A Deep Learning Model That Predicts Drug Effectiveness from Cancer Genomic Signature: Yoosup Chang, Scientific Report,. 8857 (2018) (011) Genome-scale signatures of gene interaction from compound screens predict clinical efficacy of targeted cancer therapies. Peng Jiang, et al., Cell Systems, 6,1-12 (2018) (012) eQTL: Maud Fagny, et al., PNAS, E7841-E7850 (2017) (013) pQTL: Jerome Carayol, et al., Nat Commun., 8:2084 (2017)
본 발명은 상기와 같은 종래의 문제점을 해결하기 위하여 안출된 것으로, 본 발명은 전술한 바와 같은 기술배경 및 사회적 요구에 따라, 암 약물의 반응성을 반응 대상 유전체의 유전특성 및 지문을 기능성 정보를 가진 하플로타입으로 변환하여 높은 정밀도의 약물 적응증 및 민감성 예측 시스템을 제공하기 위한 것으로, 본 발명의 구체적인 목적은, 공지된 비-임상용 세포주 유전체, 그것 들의 유전자 발현정보 및 유전자 복제수변이, 그리고 생체내 약물반응과 관련을 양적형질위치(QTL: quantitative trait loci)들의 모음(기능성 하플로타입) 정보기반 선형 회귀 모델링 및 딥러닝 기계학습을 신뢰성 있게 예측할 수 있는 예측 시스템을 제공하기 위한 것이다.
그리고 본 발명에서는 본 발명에 의한 GBLscan방법에 의해 유전자 RNA발현 및 복제수변이(CNV)와 상관관계가 높은 양적 형질 위치 (QTL)들을 수집하여 기능정보를 가진 다중변이기반 하플로타입을 생성하고 약물 민감성 및 반응성을 효과적으로 필터링하는 가상임상(In Silico Clinical Trial)을 위한 약물 반응성을 예측하는 방법을 제공하기 위한 것이다.
상기한 바와 같은 목적을 달성하기 위한 본 발명의 특징에 따르면, 본 발명은 검사 대상 양적형질 위치(QTL)들의 위치 모음 생성하는 단계와; 기능 하플로타입(FRH)과 약물반응 상관관계 계산하는 단계와; 그리고, 기능 하플로타입기반 약물반응 예측모델 생성하는 단계로 구성된다.
우선, 양적형질 위치 (QTL)들의 위치 모음 생성하기 위한 제1단계에서는; 기능 연관 하플로타입(FRH)과 약물반응성 상관관계 계산을 수행하기 위하여, (A) 약 1,000개의 세포주에서 약 4백만 변이와 약 20,000 유전자 발현 상관관계 계산하고, 그리고, (B) 약물(265개)과 1,000개 셀라인 유전체의 각 20,000여개 유전자발현 및 유전자 복제수변이 들과의 상관관계 계산한다.
이때, (A)단계 및 (B)단계는 공통 변수로 유전자 발현 및 유전자 복제수변이들을 모두 포함하는데, 이러한 공통변수인 유전자발현 정보를 활용하여 약물반응에 영향을 주는, 다중 혹은 단일변이와 연관을 가진 변이를 수집한다. 이것을 양적형질 위치 (QTL)들의 위치 모음이라고 한다.
그리고 유전체통합 DB에서 각 세포주 유전체에서 단일 및 다중변이정보를 수집하여 기능 하플로타입을 만들고 동일 세포주에서 약물반응성 정보와 함께 추출하고, 이러한 기능 하플로타입 들을 기능 하플로타입, FRH(Functionally relevant haplotope)으로 정의하고, FRH를 해시넘버 (hash number)로 표현 한다.
그리고 제2단계에서는, 기능하플로타입(FRH)과 약물반응 상관관계 계산하기 위하여, 하플로타입(FRH)를 해시넘버(hash number)로 변한하고, 변환된 해시넘버를 사용하여 약물반응성정보와 조합 상관관계 테스트(Pairwise Pearson Test)를 수행하고, 이를 모든 암 종에서 위의 작업을 반복 한다.
기능하플로타입기반 약물반응 예측모델 생성하는 제3단계에서는, 특정 암에서 약물 패스웨이(drug pathway)기반 약물반응 예측모델 생성관련 과정을 다음과 같이 수행한다.
(1) 기능연관 하플로타입과 특정 암 및 특정약물 패스웨이(Drug Pathway)와 관련된 각 약물과 상관관계를 계산하고, (2) 기능하플로타입 및 약물반응성 상관관계 메트릭스에서 X축 및 Y축의 상관관계 정보를 클러스터링을 하며, (3) 각 예측모델에서 유의성(p-value)이 높은 것을 수집하여 모델에 상호작용 기능을 모델에 적용하여 선형 회귀 모델을 계산한다, 그리고, 마지막으로 (4) NGS 데이터를 입력으로 하여 약물반응성과 연관을 가진 기능하플로타입를 계산하고 선형 회귀 모델을 사용하여 약물반응성을 예측한다.
그리고 본 발명은, 전술한 바와 같은 기능 하플로타입 정보를 활용하여 약물반응성 예측 모델을 계산하기 위해, 검사 대상 유전체로부터 수집된 염기서열에서 다수의 변이들을 활용하여 기능 하플로타입 들을 계산하는 단계와: 선형 회귀 모델의 해를 계산하는 단계와; 이러한 해를 이용하여 암약물 중에 민감성이 높은 암 약물을 선별하는 시스템을 포함한다.
한편, 본 발명의 다양한 실시예 중 일 실시예를 설명하면, 본 발명은 (A) 약물반응에 영향을 미치는 변이들에 대한 양적형질위치(QTL)들의 위치모음을 산출하는 단계와; (B) 상기 양적형질위치(QTL)에 포함된 변이에 대한 기능하플로타입을 생성하는 단계와; (C) 상기 기능하플로타입을 기반으로 변이와 약물반응 상관관계 계산하는 단계; 그리고 (D) 상기 기능하플로타입을 기반으로 약물반응성을 예측하는 단계를 포함하여 수행될 수 있다.
이때, 상기 제(A)단계의 양적형질위치(QTL)들의 위치모음을 산출은, (A1) 복수의 세포주로부터 변이들과 유전자 RNA 발현의 상관관계를 도출하는 단계와; (A2) 약물들과 복수의 셀라인 유전체에 포함된 유전자 RNA발현 및 유전자 복제수변이(CNV)들과의 상관관계 도출하는 단계와; (A3) 상기 제(A1)단계 및 제(A2)단계에서 공통 적으로 상관관계에 영향을 미치는 유전자 RNA 발현 또는 유전자 복제수변이에 대한 유전자 발현 정보를 산출하는 단계; 그리고 (A4) 상기 유전자 발현정보에 관여된 단일 또는 다중 변이를 산출하여, 약물반응에 영향을 미치는 변이들에 대한 양적형질위치(QTL)를 산출하는 단계를 포함하여 수행되는 양적형질위치(QTL)들의 위치모음 생성 단계를 포함하여 수행될 수 있다.
그리고 상기 제(B)단계의 기능하플로타입의 생성은, 유전체통합DB로부터 양적형질위치(QTL)에 포함된 단일 또는 다중변이에 대한 하플로타입을 약물반응성과 함께 추출하여 생성될 수도 있다.
또한, 상기 기능하플로타입은, 유전자 RNA발현(Exp)과 약물반응성과의 상관관계 정보와; 유전자 다중변이(loci)와 약물반응성과의 상관관계 정보를 포함하여 구성될 수도 있다.
한편, 상기 기능하플로타입은, 유전자 복제수변이(CNV)와 약물반응성과의 상관관계 정보와; 유전자 다중변이(loci)와 약물반응성과의 상관관계 정보를 포함하여 구성될 수도 있다.
여기서 상기 유전자 다중변이(loci)는, 양적형질위치(QTL)기반으로 선별된 로커스(locus)들의 모음일 수도 있다.
그리고 상기 유전체통합DB는, 지노타입(Genotype)으로 구성된 셀라인(Cell Lines) 통합 DB일 수도 있다.
또한, 상기 약물 반응성은, ln Ic50 값으로 표현될 수도 있다.
그리고 상기 유전자 RNA발현은, 과발현(over-expression), 변화없음(normal) 및 저발현(under-exprfession)으로 구분될 수도 있다.
또한, 상기 복제수변이(CNV)는, 증폭(amplification), 변화없음(normal) 및 감소(deletion)로 구분될 수도 있다.
한편, 상기 제(C)단계의 상관관계 계산은, (C1) 유전자 다중변이(loci)와 연관된 유전자 RNA발현(Exp)를 판별하는 단계와; (C2) 상기 기능하플로타입으로부터 상기 유전자 RNA발현(Exp)에 대한 약물반응성을 산출하여 상기 유전자 다중변이(loci)에 대한 약물반응성을 판별하는 단계; 그리고 (C3) 상기 기능하플로타입에 포함된 유전자 다중변이(loci)와 약물반응성과의 상관관계 정보로부터 산출된 약물반응성과 상기 제(C2)단계에서 판별된 약물반응성을 비교하여 검증하는 단계를 포함하여 수행될 수도 있다.
그리고 상기 제(C1)단계의 연관은, 상기 유전자 다중변이(loci)가 포함된 세포주 및 상기 세포주에 포함된 유전자 RNA발현(Exp)정보를 판별함에 의해 수행될 수도 있다.
또한, 상기 제(D)단계의 약물반응성을 예측은, 유전자 RNA발현 차이에 대한 약물반응의 차이가 과발현보다 저발현이 큰 경우, 유전자 RNA의 저발현이 약물반응에 민감한 것으로 판단하고; 유전자 RNA발현 차이에 대한 약물반응의 차이가 과발현보다 저발현이 작은 경우, 유전자 RNA의 과발현이 약물반응에 민감한 것으로 판단할 수도 있다.
그리고 상기 제(D)단계의 약물반응성을 예측은, 과발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값이 저발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값보다 크면, 유전자 RNA의 과발현이 유전자 다중변이(loci)타입과 연관된 것으로 판별하고; 과발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값이 저발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값보다 작으면, 유전자 RNA의 저발현이 유전자 다중변이(loci)타입과 연관된 것으로 판별할 수도 있다.
한편, 상기 기능하플로타입은, 해시넘버 (hash number)로 표현될 수도 있다.
그리고 상기 기능하플로타입과 약물반응의 상관관계는, 해시넘버를 이용하여, 약물반응성정보와 조합상관관계 테스트(Pairwise Pearson Test)를 수행함에 의해 산출될 수도 있다.
한편, 본 발명은 전술한 바와 같은 방법으로 기능하플로타입을 생성하는 약물반응성, 유전자발현정보 및 복제수 변이를 이용한 기능하플로타이핑 시스템을 포함한다.
이때, 상기 기능하플로타입은, 약물에 대한 반응성 진단, 약물에 대한 환자군을 선별하는 동반진단을 위한 바이오마커 발굴, 약물표적발굴 또는 약물에 대한 가상임상에 사용될 수도 있다.
위에서 살핀 바와 같은 본 발명에 의한 가상임상을 위한 EGFR 약물반응성에 관한 본 발명에서는 다음과 같은 효과를 기대할 수 있다.
즉, 본 발명에서는 EGFR 타입의 약물들에 대한 바이오 마커들을 통해, EGFR 약물에 대하여, 대상자 유전형질별 민감성을 예측할 수 있으므로, 개인별 맞춤의학 분야뿐만 아니라 신약 후보군 발굴에 효과적인 예비검증이 이루어지도록 하는 효과가 있다.
그리고 본 발명에서는 체내(in vivo), 체외(in vitro) 혹은 유전정보에 대한 알려진 약물의 반응성 결과들로부터, 약리 효과가 밝혀지지 않은 약물의 반응성 정도를 예측할 수 있는 효과가 있다.
또한, 본 발명은 유전체의 변이정보에 대한 약물을 구성하는 약리 관능기의 반응성 상관관계를 도출할 수 있으므로, 분석대상인 유전체의 변이 및 약물의 약리 관능기를 추출하면, 해당 유전체에 대한 약물의 반응성 정도를 신뢰성 있게 예측할 수 있는 효과가 있다.
그리고 본 발명은 유전체의 변이 특성정보에 대한 약물타입의 반응성 상관관계를 도출할 수 있으므로, 분석대상인 유전체의 변이에 대한 특성정보 및 약물타입정보를 알면, 해당 유전체에 대한 약물의 반응성 정도를 신뢰성 있게 예측할 수 있는 효과가 있다.
이를 통해 본 발명은, 미지의 고분자화합물(약물 개발 대상 물질)의 특정 유전체를 포함하는 세포주 혹은 인체에 대한 반응성을 임상시험 전에 예측할 수 있으므로, 신약 개발에 따른 시간 및 비용을 현저하게 줄일 수 있는 효과가 있으며, 이미 개발된 약물에 대하여도, 임상에서 밝혀진 유전체 이외의 다른 유전체에 대한 반응성 정도를 미리 예측할 수 있으므로 기존 약물에 대한 다른 용도의 발견 및 부작용 발견에 대한 연구 비용 및 시간을 현저히 줄여주는 효과가 있다.
도 1은 본 발명에 의한 약물반응예측을 위한 양적 형질 위치(QTL), 유전복제수변이 및 RNA발현예를 도시한 예시도.
도 2는 본 발명에 의한 유전적 바이오마커를 활용한 약물반응성 계산 스키마를 도시한 예시도.
도 3은 본 발명에 의한 유방암의 유전적 바이오마커와 약물반응성의 관계를 도시한 예시도.
도 4는 본 발명에 의한 NGS입력과 약물반응 및 RNA발현 네트워크를 도시한 예시도.
도 5는 본 발명에 의한 세포주 약물반응 값(IC50)과 기능하플로타입의 상관관계를 도시한 예시도.
도 6은 본 발명에 의한 양적형질 위치(QTL)와 약물반응 상관관계를 도시한 예시도.
도 7은 본 발명에 의한 변이, RNA발현, 유전자복제수변이 및 약물반응 네트워크를 도시한 예시도.
도 8은 본 발명에 의한 변이와 상관관계 세포주, 암, 약물반응, RNA발현 및 CNV증폭 예를 도시한 예시도.
도 9는 본 발명에 의한 기능하플로타입과 약물반응성 상관관계 계산 스키마를 도시한 예시도.
도 10은 본 발명에 의한 기능하플로타입와 약물반응성 네트워크를 도시한 예시도.
도 11은 본 발명에 의한 기능하플로타입과 유전자발현 및 유전자복제수변이 예를 도시한 예시도.
도 12는 본 발명에 의한 기능하플로타입 정의를 도시한 예시도.
도 13은 본 발명에 의한 FRH 방법과 유전자 발현과 약물 반응성 예측 예를 도시한 예시도.
도 14는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.0인 실시예를 도시한 예시도.
도 15는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.5인 실시예를 도시한 예시도.
도 16은 본 발명에 의한 기능하플로타입과 유전자발현 실시 예를 도시한 예시도.
도 17은 본 발명에 의한 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델 생성예를 도시한 예시도.
도 18은 본 발명에 의한 기능하플로타입과 약물반응성 연관관계 R^2를 도시한 예시도.
도 19는 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH의 실시예를 도시한 예시도.
도 20은 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH를 사용한 예측 모델의 일 실시예를 도시한 예시도.
도 21은 본 발명에 의한 FRH를 사용한 혈액암의 약물반응성 예측의 일 실시예를 도시한 예시도.
도 22는 본 발명에 의한 FRH를 사용한 활용가능 시스템의 일 예를 도시한 예시도.
도 23은 본 발명에 의한 FRH 바이오마커를 이용하여 암 및 약물 동반진단 칩을 제작하는 방법의 일 예를 도시한 예시도.
도 24는 본 발명에 의한 바이오마커 표현구조의 구성을 설명하는 예시도.
도 25는 주요 바이오마커들의 혈액암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 26은 주요 바이오마커들에 의해 발현된 유전자들과 혈액암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 27은 주요 바이오마커들의 여성암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 28은 주요 바이오마커들에 의해 발현된 유전자들과 여성암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 29는 주요 바이오마커들의 뇌종양 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 30은 주요 바이오마커들에 의해 발현된 유전자들과 뇌종양 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 31은 주요 바이오마커들의 두경부암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 32는 주요 바이오마커들에 의해 발현된 유전자들과 두경부암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 33은 주요 바이오마커들의 폐암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 34는 주요 바이오마커들에 의해 발현된 유전자들과 폐암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 35는 주요 바이오마커들의 육종암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 36은 주요 바이오마커들에 의해 발현된 유전자들과 육종암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 37은 주요 바이오마커들에 대한 ABL 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 38은 주요 바이오마커들에 대한 CHROMATIN 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 39는 주요 바이오마커들에 대한 EGFR 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 40은 주요 바이오마커들에 대한 ERK_MAPK 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 41은 주요 바이오마커들에 대한 IGFR 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 42는 주요 바이오마커들에 대한 MITOSIS 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
이하에서는 첨부된 도면을 참조하여 본 발명의 구체적인 실시예에 의한 가상임상을 위한 암약물반응성, 연계된 유전자발현정보 및 복제수 변이를 이용한 기능 하플로타이핑 시스템 및 방법을 살펴보기로 한다.
설명에 앞서 먼저, 본 발명의 효과, 특징 및 이를 달성하는 방법은 첨부되는 도면과 함께 상세하게 후술되어 있는 실시 예에서 명확해진다. 그러나 본 발명은 이하에서 개시되는 실시 예들에 한정되는 것이 아니라 서로 다른 다양한 형태로 구현될 수 있으며, 단지 본 실시 예들은 본 발명의 개시가 완전하도록 하고, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자에게 발명의 범주를 완전하게 알려주기 위해 제공되는 것이며, 본 발명은 청구항의 범주에 의해 정의될 뿐이다.
본 발명의 실시 예들을 설명함에 있어서 공지 기능 또는 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명을 생략할 것이며, 후술되는 용어들은 본 발명의 실시 예에서의 기능을 고려하여 정의된 용어들로서 이는 사용자, 운용자의 의도 또는 관례 등에 따라 달라질 수 있다. 그러므로 그 정의는 본 명세서 전반에 걸친 내용을 토대로 내려져야 할 것이다.
도 1은 본 발명에 의한 약물반응예측을 위한 양적 형질 위치(QTL), 유전복제수변이 및 RNA발현예를 도시한 예시도이고, 도 2는 본 발명에 의한 유전적 바이오마커를 활용한 약물반응성 계산 스키마를 도시한 예시도이며, 도 3은 본 발명에 의한 유방암의 유전적 바이오마커와 약물반응성의 관계를 도시한 예시도이고, 도 4는 본 발명에 의한 NGS입력과 약물반응 및 RNA발현 네트워크를 도시한 예시도이며, 도 5는 본 발명에 의한 세포주 약물반응 값(IC50)과 기능하플로타입의 상관관계를 도시한 예시도이고, 도 6은 본 발명에 의한 양적형질 위치(QTL)와 약물반응 상관관계를 도시한 예시도이며, 도 7은 본 발명에 의한 변이, RNA발현, 유전자복제수변이 및 약물반응 네트워크를 도시한 예시도이고, 도 8은 본 발명에 의한 변이와 상관관계 세포주, 암, 약물반응, RNA발현 및 CNV증폭 예를 도시한 예시도이며, 도 9는 본 발명에 의한 기능하플로타입과 약물반응성 상관관계 계산 스키마를 도시한 예시도이고, 도 10은 본 발명에 의한 기능하플로타입와 약물반응성 네트워크를 도시한 예시도이며, 도 11은 본 발명에 의한 기능하플로타입과 유전자발현 및 유전자복제수변이 예를 도시한 예시도이고, 도 12는 본 발명에 의한 기능하플로타입 정의를 도시한 예시도이며, 도 13은 본 발명에 의한 FRH 방법과 유전자 발현과 약물 반응성 예측 예를 도시한 예시도이고, 도 14는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.0인 실시예를 도시한 예시도이며, 도 15는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.5인 실시예를 도시한 예시도이고, 도 16은 본 발명에 의한 기능하플로타입과 유전자발현 실시 예를 도시한 예시도이며, 도 17은 본 발명에 의한 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델 생성예를 도시한 예시도이고, 도 18은 본 발명에 의한 기능하플로타입과 약물반응성 연관관계 R^2를 도시한 예시도이며, 도 19는 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH의 실시예를 도시한 예시도이고, 도 20은 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH를 사용한 예측 모델의 일 실시예를 도시한 예시도이며, 도 21은 본 발명에 의한 FRH를 사용한 혈액암의 약물반응성 예측의 일 실시예를 도시한 예시도이고, 도 22는 본 발명에 의한 FRH를 사용한 활용가능 시스템의 일 예를 도시한 예시도이며, 도 23은 본 발명에 의한 FRH 바이오마커를 이용하여 암 및 약물 동반진단 칩을 제작하는 방법의 일 예를 도시한 예시도이고, 도 24는 본 발명에 의한 바이오마커 표현구조의 구성을 설명하는 예시도이다.
본 발명은 기본적으로, (A) 암 환자에게서 임상적으로 추출하기 어려운 유전자 RNA 발현정보 및 복제수변이 정보를 양적형질 위치(QTL)를 선행 계산하고, (B) 비임상 세포주 DB(GDSC 및 CCLE)와 같은 공용 데이터를 이용하여 유전자 RNA 발현정보 및 복제수변이 정보와 약물반응성 상관관계 실험 정보를 확보한 후, 상기 제(A)단계 및 제(B)단계를 통합하여 양적형질 위치(QTL)와 암약물반응 상관성을 계산하여 예측모델을 생성한다.
그리고 암 환자에게서 획득될 수 있는 유전체 정보를 기반으로 기능정보를 포함한 하플로타입을 계산하여 암환자의 약물반응성정보를 예측한다.
도 1에는 약물반응예측을 위한 양적 형질 위치(QTL), 유전복제수변이 및 RNA발현 예가 도시되어 있다. 즉, ①의 eQTL 실험 예문에서는, 변이와 발현의 직접(cis) 및 간접(trans)방식에 의해 조절되는 것이 나타나있고, ②의 Drug-Gene Expression은 약물과 RNA 발현의 상관관계를 보여준다. 그리고 ③의 Drug Cell viabillity는 약물의 농도와 세포의 활성관계를 보여주고, ④의 Drug-CNV는 약물의 농도와 유전자 복제수 변이(CNV)와의 상관관계를 보여준다. 그리고 ⑤의 Expression-CNV는 유전자 발현과 복제수 변이(CNV)와 상관관계를 보여준다.
즉, 도 1은 약물의 농도와 RNA 발현 및 유전자복제수변이(CNV)가 서로 상관관계를 가지고 있다는 것을 보여주고, 또한, 많은 경우에 RNA발현 및 유전자복제수변이(CNV)는 그것의 원인이 되는 단일 및 다중 변이와의 상관관계가 있음을 보여준다.
도 2에는 유전적 바이오마커를 활용한 약물반응성 계산 스키마에 있어, 대부분의 알려진 활성 약물이 약물에 민감한 군과 약물에 저항성을 주는 군으로 나누어지고, 이때, 민감성 및 저항성은 유전적 바이오마커와 밀접하게 연결되어 있다.
여기서, 유전적 바이오마커는 생식 및 체세포 변이, 드라이버변이, 복제수변이, 기능 하플로타입 변이, 후성 변이인 methylation 및 유전자 발현 등으로 구성된다.
그리고, 도 3에는 유방암의 유전적 바이오마커와 약물반응성의 관계의 일예가 도시되어 있다. 유전적바이오마커들의 메커니즘을 나타내는 A) 계략도에서 Her2 유전자가 과발현되어 있을 때, 세포표면 수용체를 표적으로 하는 약물인 tratuzumab와 세포 내부의 cytoplasm에서의 길항제를 표적으로 하는 lapatinib 및 두 개의 바이오마커 PI3CA와 PTEN의 위치가 나타나 있다. B) 그래프에는 tratuzumab 및 lapatinib의 경우 wild type과 PI3CA가 변이를 가진 경우와, PTEN까지 기능을 못하는 경우에 대하여 약물반응성이 계산된 결과가 나타나 있고, 약물 pathway 메카니즘에서 약물표적의 위치에 따라 바이오마커의 변이가 1개 및 2개에 대한 약물반응성이 달라짐이 도시되어 있다.
한편, 도 4에는 NGS 입력과 약물반응 및 RNA발현 네트워크의 일 예가 도시되어 있다.
NGS 입력과 약물반응 및 RNA발현 네트워크의 기본 구조는, A) NGS 입력데이터로부터 선행으로 계산된 양적형질 위치(QTL)기반 유전자 RNA 과발현/저발현 및 유전자 복제수 변이의 증폭/감소를 예측하고, B) 비임상(in vitro) 공용 약물 반응성 데이터와 유전자발현 데이터와 상관관계 정보를 이용하여, C) 임상(in vivo)에서 양적형질 위치(QTL)기반 약물반응을 예측한다.
본 발명은 A) 양적형질 위치(QTL) 정보를 확보하고, B) 유전자 RNA 발현정보와 약물반응성 실험데이터를 라이브러리(DB)화하고, C) 약물반응성을 예측하는 과정으로 설명될 수 있다. 이는 일반적으로 환자에 대하여 B) 단계의 약물반응정보 및 유전자발현 정보를 짧은 시간에 확보하기가 어럽거나 일부는 거의 불가하기 때문이다.
따라서, 도 1 내지 도 4는 환자로부터는 유전체정보 및 RNA발현정보 기반 양적형질 위치(QTL) 정보와 관련을 가진 단일 및 다중 변이정보를 확보하고, 공용 약물반응성 정보인 비임상(in vitro) 세포주 실험 정보와 연결을 만들고, 임상(in vivo)에서 환자에게 적용하는 방식이다.
도 5는 세포주 약물반응 값(IC50)과 기능하플로타입의 상관관계 예시도로, 도 5에는 최종적으로 세포주들과 약물반응성 정보 및 기능하플로타입의 상관관계를 Pearson 상관관계로 계산하는 예가 도시되어 있다. 도 5에서는 265개 약물을 18(Dn)개 약물 pathway로 분류하여 적용을 하고, 기능하플로타입은 12개 암종(Cancer N)에 대하여 각 세포주 유전체에서 양적형질 위치(QTL) 정보기반으로 이미 약물반응과 관련을 가지고 있는 변이들의 조합(다중변이)들을 해시 수(hash number)로 바꾸어서, Pearson 상관관계를 구하는 형태의 계략도를 보여준다.
그리고 도 6은 양적형질 위치(QTL)와 약물반응 상관관계 예시도도를 보여 주고 있다. ①은 eQTL, ②는 cQTL, ③은 dQTL, ④는 유전자 RNA 발현과 유전자복제수변이의 상관관계, ⑤는 약물농도와 유전자 RNA발현, ⑥은 약물농도와 유전자복제수변이와의 상관관계를 보여준다.
본 발명에서 ① eQTL 및 ② cQTL이 사용되고, ③ 내지 ⑥은 결과물로서 혹은 상관관계가 있는 상태를 보여준다.
도 7은 변이, RNA발현, 유전자복제수변이 및 약물반응의 네트워크 구조를 나타내는 예시도로, 도 6에 도시된 내용을 서로 간의 연관성 관점으로 네트워킹을 만든 계략도이고, 지노타입(단일 변이), 하플로타입(조합 및 다중변이) 및 약물반응과의 조건식들의 관계를 보여준다.
본 발명에서 기능하플로타입은 단일변이 및 다중변이를 모두를 통칭한다.
그리고 각 변이들은 모두 양적형질 위치(QTL)의 방법에 의하여, 유전자 RNA 발현과 유전자복제수변이의 상관관계가 p-value < 10^5 이하로 정하여 수집된다.
한편, 도 8에는 변이와 상관관계 세포주, 암, 약물반응, RNA 발현 및 CNV 증폭의 예가 도시되어 있다. 이때, 상호 연관된 변이와 세포주, 암, 약물반응, RNA 발현 및 CNV 증폭의 예는 최종적으로 선별된 양적형질 위치(QTL)기반 약물반응성-변이-RNA발현-CNV가 하나의 객체로서 묶여 있다.
또한, 변이(지노타입)은 염색체의 위치, 변이 타입, 아미노산변이, 바이오마커로서의 활용 유무정보 등과도 연결될 수 있다.
한편, 도 9에 도시된 기능하플로타입과 약물반응성 상관관계 계산 스키마에 의하면, 본 발명은 크게 제1단계 및 제2단계로 구성된다.
제1단계는 양적형질 위치(QTL)들의 위치 모음을 생성하는 단계이고, 제2단계는 기능하플로타입과 약물반응 상관관계 계산하는 단계이다.
구체적으로, 제1단계는 1) 변이(전체 4백만)와 유전자들(20,000)의 발현 상관관계 계산하는 단계와, 2) 약물(265개)과 셀라인 유전체(1,000개)의 유전자발현과(각 20,000 여개)의 상관관계 계산하는 단계와, 3) 1) 및 2)에서 다중 혹은 단일변이와 연관을 가진 유전자발현 패턴이 같은 것을 수집하는 단계 및 4) 유전체통합DB에서 하플로타입(단일 및 다중변이)을 약물반응성과 함께 추출하는 단계를 포함하여 수행된다.
그리고 제2단계는 5) 이와 같은 하플로타입을 기능과 연관관계 하플로타입인 기능하플로타입(FRH)으로 정의하고, FRH를 해시넘버 (hash number)로 표현하는 단계 및 6) 해시넘버와 약물반응성 조합 상관관계 테스트(Pairwise Pearson Test)를 계산하는 단계를 포함하여 수행되고, 이들 과정을 모든 암 종에서 반복 수행한다.
또한, 도 10에는 기능하플로타입과 약물반응성의 네트워크가 도시된 것으로, 도 9에 도시된 기능 하플로타이핑 방법을 구현하기 위한 시스템을 나타낸다.
즉, QTL방법에 의한 단일 혹은 다중변이와 유전자 RNA발현 및 약물 반응데이터의 관계 및 Genotype으로 구성된 Cell Lines(c1~c-N) 통합 DB에서 다중변이를 추출하여 기능하플로타입을 추출하는 과정이 도시되어 있다.
그리고 도 11의 기능하플로타입과 유전자 RNA 발현 및 유전자복제수변이 예시도에는, 기능적인 관점에서 도 9의 과정을 구체적으로 설명을 한다.
즉, A)는 약물반응성 정보와 유전자 RNA발현의 관계를 최종결과물인 다중면이(loci)와 Exp으로 표현되고, 약물반응성 정보와 유전자복제수변이(CNV)의 관계를 loci와 CNV로 표현됨을 나타내고 있다.
그리고 B)는 이에 대한 상세 스키마로, 약물의 경우 Ln Ic50의 경우 '-2'는 민감성을 나타내고, '0'은 중간 민감성을 나타내며, '2'는 약물내성을 나타낸다.
한편, 다중변이(loci)는 양적형질 위치(QTL)기반으로 선별된 locus들의 모음으로 설명되고, loci는 다양한 타입인 loci-1, loci-2, ... loci-N으로 표현이 되며, 각 loci 타입은 전체 집단에서의 빈도(frequency)를 가지게 된다.
그리고 각각의 빈도 군에서 평균 약물반응성 정보인 ln IC50값(X, Y, …Z)이 산출된다.
한편, 유전자 RNA발현의 경우는 3가지 다른 발현 패턴을 가지는데, 이는 과발현(over-expression), 변화없음(normal), 및 저발현(under-exprfession)형식으로 표현이 될 수 있고, loci 타입과 같은 방식으로 각 타입에서 빈도(frequency)가 그룹화가 될 수 있고, 각 그룹에서의 평균 Ln IC50값(X', Y', …Z')이 산출된다.
그리고 같은 방식으로 복제수변이인 CNV의 경우도 증폭(amplification), 변화없음(normal) 및 감소(deletion)로 구분되고, 각 빈도(frequency) 군(group)에서 평균 약물반응성 정보인 ln IC50값(X", Y", …Z")이 산출된다.
또한, loci, gene-exp, gene-CNV 모두 다 빈도값이 가중치형태로 0~1의 스케일로 표현될 수 있다.
따라서, B)는 loci와 Exp, loci와 CNV에 가중치가 곱해진 것으로 설명될 수 있다.
도 12는 기능 하플로타입 정의를 나타내는 것으로, 본 발명에서 상대 기능 하플로타입(relative-Haplotype)이라 함은, 기능하플로타입(FRH)과 eQTL에서 유의성을 주는 locus들의 조합(Loci)으로서 기능적으로 연관된 하플로타입 관계를 말한다.
여기서, 기능하플로타입은 게놈 어셈블버전인 Dec. 2013 (GRCh38/hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 참고(reference)서열을 기준으로 개별 세포주 및 개인이 다른 다형성정보(allele)를 가진 형태로 정의된다. 그리고 FRH(Exp | IC50)는 유전자 발현차이에 대한 약물반응 절대값 민감도 차이(Normal 대 Over 혹은 Under)를 나타내고, FRH(Loci | IC50)는 세포주 들에 대한 기능적으로 연관된 하플로타입에 대응된 약물반응 절대값 민감도 차이를 말한다.
따라서, 약물반응값과 유전자 RNA발현의 관계와, Loci의 특정 타입과 같은 패턴의 유전자 RNA발현을 연결을 지을 수 있고, 일 예로, 도 12에서, [2]의 loci-3과 [1]Exp-over와 연결되어 있음을 보여준다.
즉, loci-3은 RNA발현이 over가 되는 것과 QTL관계에 있고, RNA발현이 over가 되어 있을 때 약물반응성 값은 loci-3의 약물발현성 값과 같은 것으로 예측할 수 있다.
또한, [3]에 도시된 바와 같이, FRH(Exp | IC50)은 변화없음(normal)에서의 약물반응성값과 비교하여 절대값 약물반응성 차이가 큰 값(max)를 나타내고, FRH(Loci | IC50)는 다양한 하플로타입에서의 약물반응 변화없음(normal)에서의 약물반응성 값과 비교하여 절대값 약물반응성 차이가 가장 큰 값(max)를 나타낸다.
한편, 도 13에는 FRH 방법과 유전자 발현과 약물 반응성을 예측한 예를 통하여, 도 12에 정의된 하플로타입을 좀 더 구체적으로 설명을 할 수 있다.
즉, 도 13의 [1] 및 [2]은 유전자 발현차이에 대한 약물반응 절대값 민감도 max 차이(Normal 대 Over 혹은 Under)를 각각 나타내고, [3]은 세포주 들에 대한 기능적으로 연관된 하플로타입에 대응된 약물반응 절대값 민감도 max 차이를 나타내며, [4]는 발현 차이에 대한 약물반응의 차이가 저발현 보다 더 크면 s=1, 그리고, 그 반대면 s=0이라 정의하는 것을 나타낸다. 따라서, s=1은 과발현이 약물반응에 민감하다는 것이고, S=0은 저발현이 약물반응이 민감하다는 것을 의미한다.
그리고 [5]는 [1] 및 [2]에서 정의한 ds^over가 ds^under보다 크면 m=1, 그렇지 않으면 m=0이라 정의하는 것을 나타내고, m=1이면 특정 loci타입이 유전자의 경우 과발현을 의미하고, m=0일 경우 유전자의 저발현이 특정 loci타입와 연관됨을 의미한다.
한편, 도 14는 FRH의 한 예시로 평균 IC50 값의 차이가 '1.0'인 예의 데이터를 표로 보여준다. 여기서, 평균 약물반응성(LN IC50)이 1인 경우 높은 양성 상관관계를 보인다 (pval <2.812*10^-7).
그리고, 도 15는 FRH의 한 예시로 평균 IC50 값의 차이가 '1.5'인 예의 데이터를 표로 보여준다. 여기서, 평균 약물반응성(LN IC50)이 1.5인 경우 훨씬 높은 음성 상관관계를 보인다 (pval <7.191*10^-7).
또한, 도 16에는 기능적으로 연관된 하플로타입과 유전자발현 실시예가 도시되어 있다.
이 실시예의 경우, 혈액암(blood)의 경우, FRH이 4개의 타입을 포함하는 것을 보여준다. 이때, 변이(locus위치)는 1: Ref Homo, 2: Hetero, 3: Alt Homo의 3개의 다른 지노타입(genotype)으로 설명이 된다.
그리고 첫 번째 컬럼의 혈액암(blood)에서 2개의 locus의 조합으로 표현하면, 각 타입의 빈도(frequency)는 두 번째 컬럼, '12'는 1명, '21'은 1명, '11'은 2명 그리고 '22'는 153명으로 다수를 보여준다.
또한, Afatinib 약물에 대하여 '11'의 경우 유전자발현은 과발현(2.404)이고, 약물반응성(LN IC50)은 -1.21, 즉 Afatinib 약물에 대하여 민감성이 있다는 것을 보여준다. 이 예시의 내용을 요약하면, 2개의 locus를 조합으로 하는 FRH는 '11' 타입에서 EGFR 유전자가 과발현되고, 그것이 원인이 되어서 약물반응성이 민감하다. 따라서, FRH는 '11' 타입을 가지는 세포주 및 환자는 Afatinib약물에 민감하다고 예측할 수 있다.
그리고 도 17에는 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델 생성 방법이 도시되어 있다. 이에 도시된 바와 같이, 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델은 1) 기능연관 하플로타입(FRH)과 특정암의 특정약물 패스웨이(Drug Pathway)와 관련된 각 약물과의 상관관계를 계산하고, 2) FRH 및 약물반응성 상관관계로 구성되는 메트릭스 X축 및 Y축의 상관관계 정보를 클러스터링을 하고, 3) 예측모델에서 유의성(p-value)이 높은 것을 수집하여, 이들의 상호작용 기능을 모델에 적용하고, 4) NGS 데이터를 입력으로 하여 약물반응성과 연관을 가진 FRH를 계산하여 약물반응성을 예측한다.
한편, 도 18에 도시된 기능하플로타입과 약물반응성 연관관계 R^2는 도 17의 예측모델 생성 방법의 2)상관관계 정보의 클러스터링 과정의 일 예를 설명한다. 여기서, 암 타입은 혈액암이고, Y: EGFR pathway 9 drugs, X: FRH 하플로타입 그리고 각 pixel은 약물반응값과 FRH의 Pearson 상관관계를 나타내고, 여기서 *는 유의성(pval<0.05)을 나타내고, **는 유의성(pval<0.01)을 나타낸다.
또한, 파랑색은 양성으로의 상관관계를 보여주고, 주황색은 음성으로의 상관관계을 보여준다.
그리고 도 19는 도 18의 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH의 예를 보여준다. 특히, 4개 FRH(LAMC2_2, JPH1_2, PRKCB_3, CML_1)와 약물반응성 상관관계를 결과를 나타내고 있다.
한편, 도 20은 도 18의 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH를 사용한 예측 모델의 일 예로, 도 17의 예측모델 생성 방법의 3) 상호작용 기능을 모델에 적용한 일 예를 설명한다. 특히, p-val<0.01이하인 FRH 21개는 상호작용 텀(term)으로 넣고, 선형 회귀(Leaner Regression)모델을 적용한 예시이다. 이 경우는 Pearson 상관관계가 0.89이다.
또한, 도 21은 혈액암 환자 1명 유전체의 기능하플로타입을 가지고 다양한 약물(AP-24534, PAC-1, Obatoclax Mesylate, Bleomycin 등)에 대한 예측된 IC50(real)값들을 보여준다. 이 결과 어떤 약물은 높은 민감도가 예측된 반면, 떤 약물은 높은 저항성이 예측된 것으로 나타난다. 그리고 실제값(IC50(real))의 민감도와 기능하플로타입 군의 평균 IC50(ave)값 사이에 일치성이 있음을 보여준다.
한편, 도 22에 도시된 바와 같이, 본 발명에 의한 차세대시퀀싱데이터 기반의 개인별 기능하플로타입들이 수집되면 다양한 영역에서 활용이 가능하다. 즉, 가상임상시험 및 실제임상시험, 신약표적발굴, 질병 약물 민감도 진단, 및 동반진단 바이오마커 발굴 시스템 등에 활용가능하다.
본 발명에서는 전술한 바와 같은 기능하플로타입을 통하여, 약물 반응성을 진단하는데 유의성있는 바이오 마커들을 발굴하였다.
발굴된 바이오 마커는 변이를 포함하는 DNA 염기로 크게 암의 종류(CancerClass) 별로 해당 암에 대한 약물의 반응성에 영향을 미치는 바이오 마커들과, 약물의 작용 경로(pathway) 및 표정 대상에 따라 구분되는 약물타입(DrugClass)에 별로 약물의 반응성에 영향을 미치는 바이오 마커들로 구분된다.
이하에서는 이와 같은 바이오 마커들을 종류별로 구분하여 정리하기로 한다.
먼저, 암타입(CancerClass)에 대한 구분 종류가 [표 1]에 정리되어 있다.
암타입(CancerClass)에 속하는 TCGA(the cancer genome atlas)의 정의
구분 CancerClass TCGA CANCER_NAME
1 혈액암(blood) ALL LAML LCML Acute lymphoblastic leukemia, Acute Myeloid Leukemia, Chronic Myelogenous Leukemia
2 여성암(breast, ovary) BRCA BLCA UCEC OV CESC Bladder Urothelial Carcinoma, Breast invasive carcinoma, Ovarian serous cystadenocarcinoma, Cervical squamous cell carcinoma and endocervical adenocarcinoma, Uterine Corpus Endometrial Carcinoma
3 뇌종양(brain) LGG NB GBM Glioblastoma multiforme, Brain Lower Grade Glioma, Neuroblastoma (nb)
4 두경부암(head&neck) HNSC THCA Head and Neck squamous cell carcinoma, Thyroid carcinoma
5 폐암(lung) LUAD LUSC NSCLC Lung adenocarcinoma, Lung squamous cell carcinoma
6 육종암(bone) SARC Sarcoma
위 [표 1]에 기재된 Cancer Class는 암발생부위 및 원인별 구분으로, 혈액암(blood), 여성암(breast, ovary), 뇌종양(brain), 두경부암(head&neck), 폐암(lung), 육종암(bone)으로 구분된다.
그리고 TCGA는 'The cancer genome atlas'에서 분류한 세부 암 유형을 나타내고, 각 항목에 대한 정보가 [표 1]에 기재되어 있다.
전술한 바와 같이, 본 발명에서는 기능하플로타입을 이용한 GBLscan을 통하여, 각 암 종류별로, 약물에 대한 반응성에 영향을 미치는 바이오마커를 산출하였다.
구체적으로, 암타입(Cancer Class)의 구분 별로, 혈액암(blood)의 바이오 마커 225개(표 2참조), 여성암(breast, ovary) 바이오 마커 50개(표 4참조), 뇌종양(brain)의 바이오 마커 894개(표 6참조), 두경부암(head&neck)의 바이오 마커 32개(표 8참조), 폐암(lung)의 바이오 마커 277개(표 10참조), 육종암(bone)의 바이오 마커 331개(표 12참조)이다.
아래 [표 2] 내지 [표 12]에는 암 종류별로 본 발명에 의해 발굴된 바이오 마커가 표시되어 있다. 여기서 바이오 마커는 단일변이 및 다중변이의 조합일 수 있고, 변이의 형태 역시 단일염기다형성변이(SNV), 인델(Indel), 유전자 복제수 변이(CNV), 염색체 전위(chromosomal rearrangement) 등 다양한 형태의 변이일 수 있다.
한편, 본 발명에서 표시되는 Gene_EXP는 도 24에 도시된 바와 같이, 해당 바이오마커의 mRNA 발현유전자의 명칭을 나타낸다. 그리고 상기 바이오 마커는 『표식1_표식2_표식3_표식4』의 형태로 표현되는데, 표식1은 변이가 포함된 염색체번호를 나타내는 것으로 1 내지 22 또는 X, Y 중 어느 하나의 값을 갖는다. 그리고 표식2는 해당 염색체 상에서 변이가 발생된 염기서열의 시작위치를 나타내는 것이며, 표식3은 변이 전 정상 염기를 나타내는 것으로 참조게놈(GRCh/hg38 기준)상의 해당 위치의 염기를 말한다. 한편, 표식4는 변이된 염기를 나타내는 것이다.
즉, [표 2] 내지 [표 12] 및 [표 15] 내지 [표 27]에 표시된 『표식1_표식2_표식3_표식4』의 형태로 표현된 변이는, 표식1 염색체에 있어, 표식2 번째 부터의 표식3 염기가 표식4로 변이된 염기서열을 말한다.
따라서, 이때, 바이오 마커는 구체적으로, 표식1 염색체에 있어, 표식2 번째 위치에서부터의 표식3의 염기 길이까지의 자리가 표식4의 염기로 구성되는 염기서열을 말한다.
예를 들어, [표 2]의 서열1의 바이오마커가 『14_30910985_T_G』로 표현되었는데, 이는 14번 염색체의 30910985번째 염기가 G인 염기서열이 바이오 마커임을 의미하고, [표 2]의 서열5의 바이오마커가 『13_113524119_TGTCA_T, 13_113510211_T_C, 13_113495576_T_C, 13_113503637_G_T, 13_113539563_C_T』로 표현되었는데, 이는 13번 염색체의 113524119번째 염기부터 113524123까지의 염기가 T이고(4자리의 염기는 '결실'됨을 의미한다), 13번 염색체의 113510211번째 염기가 C이며, 13번 염색체의 113495576번째 염기가 C이고, 13번 염색체의 113503637번째 염기가 T이며, 13번 염색체 113539563번째 염색체가 T인 염기서열이 바이오마커임을 의미한다.
도 24에 도시된 예를 살피면, [표 23]의 서열 29에 기재된 바이오 마커는, 'SLC6A12'염색체에서, 2번 염색체의 190673067번째 염기가 GT이고, 9번째 염색체의 114323991번째 염기가 G인 것을 의미한다. 이때, 2번 염색체의 190673067번째 염기는 G가 GT로 치환된 것임을 말한다.
한편, 1 내지 22번 염색체의 전체 염기서열은 전술한 바와 같이, 게놈 어셈블버전인 Dec. 2013 (GRCh38/hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 참고(reference)서열을 기준으로 한다.
[표 2]에는 혈액암(blood) 약물에 연관된 FRH 들과, 이와 연관된 혈액암 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 3] 에는 [표 2]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, [표 2]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 2]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 혈액암 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 25에는 표 2에 기재된 바이오마커들 중 주요 바이오마커들의 혈액암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 26에는 주요 바이오마커들에 의해 발현된 유전자들과 혈액암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
혈액암(blood) 약물에 대한 반응성 바이오 마커
No. FRH Drug DrugType Var(마커)
1 MYB_5 1017_Olaparib / 1054_PD-0332991 / 1175_AG-014699 / 1006_Cytarabine / 1013_Nilotinib / 1495_Olaparib / 1010_Gefitinib / 1050_ZM-447439 / 1019_Bosutinib / 1011_ABT-263 / 1021_Axitinib / 1018_ABT-888 / 1037_BX-795 / 1046_681640 / 263_FR-180204 / 6_PHA-665752 / 1053_MK-2206 / 1032_Afatinib / 1015_CI-1040 / 1020_Lenalidomide / 1066_AZD6482 / 308_XL-880 / 1033_Vismodegib / 1014_RDEA119 / 1049_PD-173074 / 1038_NU-7441 g_integrity / cell_cyc / g_integrity / DNArep / abl / g_integrity / egfr / mitosis / abl / apop / rtk / g_integrity / other / cell_cyc / erk_mapk / rtk / pi3k / egfr / erk_mapk / other / pi3k / rtk / other / erk_mapk / rtk / g_integrity 13_37746458_AA_A / 16_46710765_T_A / 11_63382198_CA_C / 14_68477626_CT_C / 7_151221500_CT_C
2 CCND3_2 1006_Cytarabine_1 / 226_GSK1070916_2 / 32_Tozasertib_2 / 1054_Palbociclib_2 / 231_FMK_3 / 1050_ZM447439_3 / 167_OSU-03012_3 / 59_WZ-1-84_3 / 197_Bryostatin_1_2 / 1495_Olaparib_1 / 177_GSK650394_3 / 282_Pelitinib_2 / 300_CX-5461_3 DNArep / mitosis / mitosis / cell_cyc / erk_mapk / mitosis / pi3k / other / other / g_integrity / other / egfr / other 14_68477626_CT_C / 7_151221500_CT_C
3 CLEC11A_2 1014_Refametinib_2 / 1526_Refametinib_3 / 1060_PD0325901_2 / 263_FR-180204_3 / 1242_(5Z)-7-Oxozeaenol_3 / 1015_CI-1040_2 / 224_AS605240_3 / 1498_Selumetinib_2 / 254_Quizartinib_2 / 29_AZ628_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / pi3k / erk_mapk / rtk / erk_mapk 16_46710765_T_A / 5_179863845_T_G
4 SLFN11_1 1494_SN-38_3 / 1259_Talazoparib_3 / 136_Mitomycin-C_1 / 1003_Camptothecin_1 / 1006_Cytarabine_1 / 226_GSK1070916_2 / 134_Etoposide_1 / 1005_Cisplatin_1 / 135_Gemcitabine_1 DNArep / g_integrity / DNArep / DNArep / DNArep / mitosis / DNArep / DNArep / DNArep 1_215675245_T_C
5 GLUL_1 1013_Nilotinib_1 / 1021_Axitinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 34_Imatinib_1 / 52_GNF-2_3 / 1050_ZM447439_3 abl / rtk / erk_mapk / erk_mapk / abl / abl / mitosis 16_46710765_T_A
6 ARRB1_1 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 29_AZ628_3 / 263_FR-180204_3 / 1242_(5Z)-7-Oxozeaenol_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / other 16_46710765_T_A
7 UBASH3B_1 1006_Cytarabine_1 / 226_GSK1070916_2 / 1050_ZM447439_3 / 211_TL-2-105_3 / 1054_Palbociclib_2 / 279_BIX02189_3 / 282_Pelitinib_2 DNArep / mitosis / mitosis / erk_mapk / cell_cyc / other / egfr 14_68477626_CT_C
8 TNFRSF1A_2 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 29_AZ628_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 16_46710765_T_A / 6_71969190_A_G
9 FLT3_1 277_Linifanib_2 / 249_Cabozantinib_1 / 254_Quizartinib_2 / 308_WIKI4_2 / 226_GSK1070916_2 / 222_BX-912_3 / 153_Midostaurin_2 rtk / rtk / rtk / rtk / mitosis / pi3k / rtk 2_110841381_C_T
10 TAF3_1 1060_PD0325901_2 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 1_75148689_A_T
11 RNF169_1 1013_Nilotinib_1 / 1021_Axitinib_2 / 261_TL-1-85_3 / 260_NG-25_3 / 211_TL-2-105_3 / 295_NVP-BHG712_3 abl / rtk / other / other / erk_mapk / rtk 6_119180436_T_TAA
12 AGTRAP_1 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 2_178769706_G_T
13 DDX60L_1 1014_Refametinib_2 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 224_AS605240_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / pi3k 6_143772215_C_T
14 MARCH9_1 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1526_Refametinib_3 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 14_30910985_T_G
15 OSBPL5_1 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1242_(5Z)-7-Oxozeaenol_3 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk 2_232380431_T_C
16 ZNF22_1 300_CX-5461_3 / 272_AR-42_2 / 226_GSK1070916_2 / 274_Belinostat_1 / 257_NPK76-II-72-1_3 / 276_CAY10603_3 other / chromatin / mitosis / chromatin / mitosis / chromatin 2_97507111_G_A
17 DGAT1_3 1014_Refametinib_2 / 1526_Refametinib_3 / 1021_Axitinib_2 / 1013_Nilotinib_1 / 1060_PD0325901_2 / 1011_Navitoclax_2 erk_mapk / erk_mapk / rtk / abl / erk_mapk / apop 3_38910262_T_C / 11_18484005_G_A / 3_38905381_A_T
18 ORMDL3_2 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 19_49044101_A_G / 2_178769706_G_T
19 ROPN1L_2 1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 / 1526_Refametinib_3 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 16_33978977_C_T / 2_200876848_T_C
20 MSI2_1 1498_Selumetinib_2 / 1526_Refametinib_3 / 1060_PD0325901_2 / 1014_Refametinib_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 22_43972861_C_T
21 PSTPIP2_2 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 6_143772215_C_T / 6_143760631_C_A
22 MYL6B_1 1498_Selumetinib_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 11_284257_G_A
23 LPAR6_2 1011_Navitoclax_2 / 1054_Palbociclib_2 / 1021_Axitinib_2 / 1050_ZM447439_3 / 226_GSK1070916_2 apop / cell_cyc / rtk / mitosis / mitosis X_136033510_GA_G / 12_131908770_A_C
24 RIPK2_5 231_FMK_3 / 226_GSK1070916_2 / 225_Genentech Cpd 10_3 / 203_BMS-345541_3 / 205_Avagacestat_2 erk_mapk / mitosis / mitosis / other / other 6_152444591_GA_G / 19_13993876_CT_C / 13_37746457_TAA_TA / 5_64507681_TA_T / 10_67956845_TA_T
25 KIF15_1 1006_Cytarabine_1 / 1054_Palbociclib_2 / 1050_ZM447439_3 / 226_GSK1070916_2 DNArep / cell_cyc / mitosis / mitosis 15_100152748_G_A
26 ATP11A_2 1498_Selumetinib_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 2_85880864_T_C / 3_132388903_G_A
27 ZYX_1_9 1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk 11_129905704_C_T
28 SNRPG_5_5 1498_Selumetinib_2 / 1060_PD0325901_2 / 1014_Refametinib_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk 7_12369637_C_A / 7_12369701_C_T / 7_12369909_A_G / 7_12361157_C_T / 7_12361395_C_T
29 RABGAP1_4_4 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 3_10260372_A_G / 17_20204460_T_C / 17_20357788_A_G / 17_20205876_C_T
30 AEBP1_5_4 1006_Cytarabine_1 / 167_OSU-03012_3 / 182_Obatoclax Mesylate_2 / 226_GSK1070916_2 DNArep / pi3k / apop / mitosis 16_13922252_CT_C / 13_37746457_TAA_TA / 1_108982799_TA_T / 6_152444591_GA_G / 17_64858885_TA_T
31 HNRNPA0_5_7 226_GSK1070916_2 / 300_CX-5461_3 / 134_Etoposide_1 / 225_Genentech Cpd 10_3 mitosis / other / DNArep / mitosis 11_63382198_CA_C / 15_42211755_GA_G / 15_55680462_CT_C / 20_34750522_TA_T / 11_33353067_AT_A
32 PVRL2_1_15 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 34_Imatinib_1 erk_mapk / erk_mapk / erk_mapk / abl 17_999610_T_C
33 KIAA1377_1_4 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 19_2896950_T_C
34 THEM4_5_4 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 / 300_CX-5461_3 / 175_PAC-1_2 mitosis / pi3k / other / apop 13_37746457_TAA_TA / 7_151221500_CT_C / 1_108982799_TA_T / 2_53919250_GA_G / 15_42211755_GA_G
35 RBM15B_4_4 1054_Palbociclib_2 / 1050_ZM447439_3 / 226_GSK1070916_2 / 1006_Cytarabine_1 cell_cyc / mitosis / mitosis / DNArep 11_63382198_CA_C / 5_75576972_GA_G / 8_73582883_GA_G / 10_67956845_TA_T
36 C10orf11_1_7 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 1_13344015_T_C
37 NSMAF_1_7 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 29_AZ628_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk 1_117088769_T_C
38 FRAT2_2_9 1526_Refametinib_3 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 1_215813880_T_C / 1_215838019_T_C
39 LRPAP1_2_3 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 7_36335190_G_A / 22_39052745_T_C
40 PRAM1_3_3 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 7_128805316_G_A / 2_178769706_G_T / 2_232380380_A_G
41 RAG1_2_3 182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 1006_Cytarabine_1 apop / apop / DNArep 19_11301321_TA_T / 4_105719027_C_A
42 CARHSP1_2_3 1006_Cytarabine_1 / 226_GSK1070916_2 / 1054_Palbociclib_2 DNArep / mitosis / cell_cyc 14_68477626_CT_C / 13_24781827_GTT_GT
43 MBLAC1_1_3 1498_Selumetinib_2 / 1014_Refametinib_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk 3_179365291_C_T
44 RAG2_3_4 1006_Cytarabine_1 / 175_PAC-1_2 / 300_CX-5461_3 DNArep / apop / other 3_112112876_TA_T / 12_21806064_CA_C / 19_11301321_TA_T
45 HNMT_1_4 1526_Refametinib_3 / 1498_Selumetinib_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk 1_1756186_T_C
46 KCTD7_2_5 1498_Selumetinib_2 / 1014_Refametinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk 11_63719914_T_C / 11_63646490_AAAAT_A
47 GSN_1_6 1498_Selumetinib_2 / 1372_Trametinib_1 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk 11_129905704_C_T
48 CBFB_2_5 1006_Cytarabine_1 / 182_Obatoclax Mesylate_2 / 1004_Vinblastine_1 DNArep / apop / cytoskeleton 15_74183919_A_G / 3_112112876_TA_T
49 FBXO33_1_4 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk 8_143538013_T_C
50 ZBED4_2_4 1054_Palbociclib_2 / 257_NPK76-II-72-1_3 / 1011_Navitoclax_2 cell_cyc / mitosis / apop 7_100590017_T_G / 22_23698377_AT_A
51 COPS8_5_6 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk 11_69072603_C_T / 11_124023539_A_G / 16_57082546_T_C / 6_31878964_C_A / 7_100220478_G_A
52 ISG20_1_12 1014_Refametinib_2 / 1060_PD0325901_2 / 263_FR-180204_3 erk_mapk / erk_mapk / erk_mapk 5_179863845_T_G
53 LGALS12_3_4 1526_Refametinib_3 / 1060_PD0325901_2 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 14_63384641_T_C / 7_128804766_A_G / 7_128805316_G_A
54 SNRNP48_5_3 1006_Cytarabine_1 / 1050_ZM447439_3 / 1054_Palbociclib_2 DNArep / mitosis / cell_cyc 16_57460490_GA_G / 16_30280420_GA_G / 8_108228149_GA_G / 1_179120104_GA_G / 9_67192757_GA_G
55 VPS37C_3_4 182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 205_Avagacestat_2 apop / apop / other 5_146267624_CT_C / 3_160416453_CT_C / 12_15623289_TA_T
56 ATP6V0A1_1_3 1494_SN-38_3 / 226_GSK1070916_2 / 1006_Cytarabine_1 DNArep / mitosis / DNArep 11_63382198_CA_C
57 HEATR5A_5_6 205_Avagacestat_2 / 226_GSK1070916_2 / 192_LFM-A13_3 other / mitosis / other 7_151221500_CT_C / 9_120989554_CT_C / 4_106236542_TA_T / 7_77937691_AT_A / 15_42211755_GA_G
58 ENG_2_8 249_Cabozantinib_1 / 308_WIKI4_2 / 263_FR-180204_3 rtk / rtk / erk_mapk 3_186558604_C_T / 22_29806785_G_C
59 USF1_5_7 228_AKT_inhibitor_VIII_3 / 182_Obatoclax Mesylate_2 / 226_GSK1070916_2 pi3k / apop / mitosis 6_163478762_CT_C / 17_46332538_GT_G / 7_74758055_CT_C / 9_100450496_GT_G / 1_176043330_GA_G
60 GRB10_2_11 1014_Refametinib_2 / 1060_PD0325901_2 / 1013_Nilotinib_1 erk_mapk / erk_mapk / abl 12_56425138_C_T / 7_51028450_A_G
61 ZNF415_2_4 286_KIN001-236_3 / 205_Avagacestat_2 / 167_OSU-03012_3 other / other / pi3k 1_225147359_GT_G / 19_1057777_GA_G
62 DMTF1_1_4 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk 1_16758972_T_G
63 MSL2_4_5 226_GSK1070916_2 / 205_Avagacestat_2 / 1050_ZM447439_3 mitosis / other / mitosis 13_37746457_TAA_TA / 8_73582883_GA_G / 5_64507681_TA_T / 7_73465568_GA_G
64 ATP7B_2_6 1013_Nilotinib_1 / 261_TL-1-85_3 / 260_NG-25_3 abl / other / other 5_176347862_G_T / 5_176336593_G_A
65 MANBAL_1_5 305_TPCA-1_3 / 1013_Nilotinib_1 / 155_Ponatinib_2 other / abl / abl 1_24074187_A_G
66 STOX1_1_3 182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 226_GSK1070916_2 apop / apop / mitosis 9_67192757_GA_G
67 PRKCB_2_4 261_TL-1-85_3 / 295_NVP-BHG712_3 / 260_NG-25_3 other / rtk / other 2_68818005_T_G / 1_24074187_A_G
68 PNPLA8_3_5 224_AS605240_3 / 1014_Refametinib_2 / 1526_Refametinib_3 pi3k / erk_mapk / erk_mapk 17_21300996_G_T / 17_21301003_T_C / 17_21301006_A_G
69 ACCS_3_2 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk 11_44107740_C_A / 9_61066407_C_T / 7_135196179_C_T
70 BANP_1_2 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk 9_33270750_G_T
71 ARID1A_2_3 1054_Palbociclib_2 / 1050_ZM447439_3 cell_cyc / mitosis 7_21862122_CT_C / 11_63382198_CA_C
72 ELOVL5_1_4 1013_Nilotinib_1 / 1054_Palbociclib_2 abl / cell_cyc 13_37746457_TAA_TA
73 N4BP2_5_2 175_PAC-1_2 / 257_NPK76-II-72-1_3 apop / mitosis 19_11301321_TA_T / 5_146267624_CT_C / 9_120989554_CT_C / 13_37746457_TAA_TA / 16_84087473_CAA_C
74 LIMS2_5_3 205_Avagacestat_2 / 226_GSK1070916_2 other / mitosis 3_196805277_CT_C / 11_63382198_CA_C / 15_41478441_CT_C / 6_166418092_GA_G / 14_54478163_TA_T
75 DPCD_1_2 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 mitosis / pi3k 15_42211755_GA_G
76 KATNB1_5_2 1006_Cytarabine_1 / 1054_Palbociclib_2 DNArep / cell_cyc 4_183646278_TA_T / 20_38562748_GT_G / 1_84490478_CT_C / 2_200412288_CT_C / X_19006308_TA_T
77 RBM18_1_3 1011_Navitoclax_2 / 1014_Refametinib_2 apop / erk_mapk 10_131944182_G_C
78 EWSR1_1_2 1054_Palbociclib_2 / 226_GSK1070916_2 cell_cyc / mitosis 14_68477626_CT_C
79 SDC4_1_5 245_UNC0638_3 / 196_Phenformin_3 chromatin / metabol 1_24074187_A_G
80 LCK_5_3 182_Obatoclax Mesylate_2 / 175_PAC-1_2 apop / apop 6_163478762_CT_C / 10_70860377_CT_C / 13_37746457_TAA_TA / 5_64507681_TA_T / 5_146267624_CT_C
81 GNA15_1_9 1011_Navitoclax_2 / 226_GSK1070916_2 apop / mitosis 9_33798019_A_G
82 S1PR2_2_8 1014_Refametinib_2 / 224_AS605240_3 erk_mapk / pi3k 1_204261453_G_A / 3_54386725_A_G
83 SOX4_2_2 226_GSK1070916_2 / 1006_Cytarabine_1 mitosis / DNArep 13_37746457_TAA_TA / 6_152444591_GA_G
84 MPP1_1_19 1013_Nilotinib_1 / 263_FR-180204_3 abl / erk_mapk 9_33798019_A_G
85 TRIM26_1_5 277_Linifanib_2 / 1526_Refametinib_3 rtk / erk_mapk 11_129905704_C_T
86 NRN1_2_2 1006_Cytarabine_1 / 175_PAC-1_2 DNArep / apop 20_24959128_C_T / 6_136108863_GA_G
87 PHACTR2_1_4 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk 5_146013801_C_T
88 TRAF3IP2_2_2 1175_Rucaparib_3 / 1017_Olaparib_2 g_integrity / g_integrity 1_149929093_CA_C / 12_27688992_CT_C
89 MLF1IP_1_2 1054_Palbociclib_2 / 1006_Cytarabine_1 cell_cyc / DNArep 10_69097096_G_A
90 PELI2_5_7 226_GSK1070916_2 / 257_NPK76-II-72-1_3 mitosis / mitosis 3_129433338_GT_G / 19_11301321_TA_T / 6_152444591_GA_G / 5_60605865_GA_G / 11_63382198_CA_C
91 HNRNPA1L2_1_2 1054_Palbociclib_2 / 1006_Cytarabine_1 cell_cyc / DNArep 11_33353067_AT_A
92 BCL11B_5_3 205_Avagacestat_2 / 231_FMK_3 other / erk_mapk 13_24781827_GTT_GT / 10_67956845_TA_T / 3_196805277_CT_C / 11_63382198_CA_C / 19_13993876_CT_C
93 TTF1_5_6 226_GSK1070916_2 / 1006_Cytarabine_1 mitosis / DNArep 8_28850105_GA_G / 6_163478762_CT_C / 13_37746457_TAA_TA / 11_63382198_CA_C / 5_146267624_CT_C
94 SKA3_1_2 1054_Palbociclib_2 / 1006_Cytarabine_1 cell_cyc / DNArep 6_163478762_CT_C
95 ECI1_1_2 205_Avagacestat_2 / 1072_Avagacestat_2 other / other 1_247588429_C_G
96 LAPTM4B_1_8 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk 20_56366031_C_T
97 C11orf74_4_5 1014_Refametinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk 2_237751320_TAA_T / 16_21533198_T_C / 2_216109160_C_A / 16_21520152_G_A
98 RNF24_1_12 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk 5_179863845_T_G
99 CRB3_1_4 1021_Axitinib_2 / 277_Linifanib_2 rtk / rtk 15_98922244_C_T
100 CNTROB_5_3 226_GSK1070916_2 / 1050_ZM447439_3 mitosis / mitosis 16_15068286_TA_T / 5_64507681_TA_T / 8_42906145_TC_T / 3_129433338_GT_G / 1_179120104_GA_G
101 KIAA1967_5_2 211_TL-2-105_3 / 257_NPK76-II-72-1_3 erk_mapk / mitosis 11_107336715_TA_T / 1_22491646_AT_A / 22_23698377_AT_A / 13_37746457_TAA_TA / 3_196805277_CT_C
102 KRT10_1_3 1014_Refametinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk 7_92671549_C_T
103 VIT_1_2 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk 1_176944072_A_T
104 TMEM173_2_7 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk 1_201199371_G_A / 1_201200426_T_G
105 SGCB_1_3 1014_Refametinib_2 / 1015_CI-1040_2 erk_mapk / erk_mapk 17_40035671_A_G
106 DTD1_3_4 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 mitosis / pi3k 5_77411610_TA_T / 2_15396385_GA_G / 11_63382198_CA_C
107 DYSF_1_3 1014_Refametinib_2 / 1015_CI-1040_2 erk_mapk / erk_mapk 1_25390874_C_G
108 AP2S1_1_3 1060_PD0325901_2 / 1372_Trametinib_1 erk_mapk / erk_mapk 10_68572309_C_T
109 EMILIN2_1_11 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk 5_179863845_T_G
110 SLC38A1_1_6 1014_Refametinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk 7_114653804_G_T
111 SGSM2_4_1 226_GSK1070916_2 mitosis 13_97982483_AT_A / 2_63842143_GA_G / 7_77256452_A_G / 4_84631729_G_T
112 ADAM15_1_1 1026_Tanespimycin_2 other 1_75148689_A_T
113 JPH1_2_1 211_TL-2-105_3 erk_mapk 16_81858185_C_G / 5_128345465_A_C
114 S100A8_1_3 1498_Selumetinib_2 erk_mapk 12_11091570_G_A
115 SQSTM1_2_1 182_Obatoclax Mesylate_2 apop 13_24781827_GTT_GT / 19_11301321_TA_T
116 ANXA2_1_1 1026_Tanespimycin_2 other 4_36214492_A_T
117 CMBL_1_2 1013_Nilotinib_1 abl 11_117203393_G_A
118 CABLES2_1_1 1053_MK-2206_2 pi3k 17_74794950_A_G
119 NDST3_2_1 205_Avagacestat_2 other 13_24781827_GTT_GT / 11_90163472_A_C
120 LMNA_1_1 1026_Tanespimycin_2 other 12_120579461_C_T
121 SP1_5_1 333_T0901317_3 other 14_35627049_G_GA / 7_23187041_C_T / 2_61835958_TA_T / X_52753184_G_T / 2_119608507_T_G
122 CDCA7_1_2 1054_Palbociclib_2 cell_cyc 20_46358679_C_G
123 NFYB_1_1 1006_Cytarabine_1 DNArep 20_46358679_C_G
124 SLFN5_2_1 1378_Bleomycin(50uM)_1 DNArep 4_186199057_C_A / 6_116125413_A_G
125 CREG1_3_1 1378_Bleomycin(50uM)_1 DNArep 9_12704725_C_T / 17_47820165_C_A / 17_47819112_T_C
126 DAD1_1_1 1006_Cytarabine_1 DNArep 12_54182016_C_A
127 SURF4_1_4 35_NVP-TAE684_3 rtk 14_101856659_C_G
128 CDK6_1_1 1011_Navitoclax_2 apop 9_33798019_A_G
129 TBCD_5_1 1054_Palbociclib_2 cell_cyc 11_63382198_CA_C / 10_67956845_TA_T / 14_68477626_CT_C / 13_37746457_TAA_TA / 8_73582883_GA_G
130 FLRT3_1_1 1378_Bleomycin(50uM)_1 DNArep 17_8012602_G_A
131 FUCA2_2_1 1526_Refametinib_3 erk_mapk 12_10418492_T_G / 1_3385157_C_T
132 MAPK7_1_1 1054_Palbociclib_2 cell_cyc 7_73465568_GA_G
133 IER3_1_1 1378_Bleomycin(50uM)_1 DNArep 20_62310091_T_G
134 U2AF1_1_1 167_OSU-03012_3 pi3k 9_76023648_GA_G
135 PLA2G12A_1_3 224_AS605240_3 pi3k 1_70189288_A_C
136 CBX2_2_1 1006_Cytarabine_1 DNArep 2_161993434_TA_T / 12_109568919_GT_G
137 MGAT4A_5_1 175_PAC-1_2 apop 13_37746457_TAA_TA / 20_2493490_GA_G / 6_41090123_AT_A / 2_53919250_GA_G / 16_30280420_GA_G
138 STARD10_1_1 1026_Tanespimycin_2 other 20_62327488_A_C
139 CSRNP2_1_1 205_Avagacestat_2 other 22_29978883_CT_C
140 DOK2_2_1 1526_Refametinib_3 erk_mapk 2_23637298_G_A / 2_23642306_G_A
141 VOPP1_1_1 308_WIKI4_2 rtk 22_38427824_A_C
142 PLOD1_1_1 175_PAC-1_2 apop 10_99880039_G_A
143 C3AR1_1_1 1014_Refametinib_2 erk_mapk 7_147977856_A_T
144 CYSLTR1_1_1 1526_Refametinib_3 erk_mapk 11_129905704_C_T
145 S100A6_1_1 1026_Tanespimycin_2 other 12_125519394_A_T
146 ZADH2_1_1 1011_Navitoclax_2 apop 4_86769845_A_G
147 EXOSC9_5_2 167_OSU-03012_3 pi3k 8_108228149_GA_G / 16_57460490_GA_G / 6_31657145_CA_C / 15_50725184_GT_G / 20_33367013_TA_T
148 ZC3H4_2_1 1054_Palbociclib_2 cell_cyc 1_247256362_C_T / 1_247256207_T_C
149 BARD1_1_2 175_PAC-1_2 apop 9_133405414_T_G
150 MCL1_1_1 1011_Navitoclax_2 apop 14_60466034_G_A
151 NINL_3_4 203_BMS-345541_3 other 13_24781827_GTT_GT / 13_37746457_TAA_TA / 11_33353067_AT_A
152 HYI_5_1 226_GSK1070916_2 mitosis 7_151221500_CT_C / 19_1057777_GA_G / 15_42211755_GA_G / 15_34915209_AT_A / 6_30329241_CA_C
153 USP49_1_1 1006_Cytarabine_1 DNArep 7_147638841_CT_C
154 EPB41_1_3 1378_Bleomycin(50uM)_1 DNArep 11_1758992_A_C
155 NFAM1_1_1 1526_Refametinib_3 erk_mapk 9_15848985_C_T
156 SIVA1_5_1 175_PAC-1_2 apop 6_163478762_CT_C / 13_37746457_TAA_TA / 2_161993434_TA_T / 9_120989554_CT_C / 13_39034198_TA_T
157 LRG1_1_2 1026_Tanespimycin_2 other 13_28073352_GA_G
158 TMPRSS15_1 1377_Afatinib_1 egfr 21_39898596_C_A
159 G0S2_1 281_Alectinib_2 rtk 5_35904512_G_T
160 PPIP5K2_2 261_TL-1-85_3 other 2_178769706_G_T / 11_129905704_C_T
161 AGPAT3_4 182_Obatoclax Mesylate_2 apop 17_76289951_CA_C / 2_63842143_GA_G / 13_97982483_AT_A / 12_48679260_CA_C
162 AS3MT_5 226_GSK1070916_2 mitosis 7_20786651_GA_G / 13_24781827_GTT_GT / 7_77937691_AT_A / 3_160416453_CT_C / 5_95507014_TA_T
163 PIK3R3_1 228_AKT_inhibitor_VIII_3 pi3k 2_53919250_GA_G
164 CRY1_2 226_GSK1070916_2 mitosis 19_1057777_GA_G / 9_33798019_A_G
165 ZNF367_1 226_GSK1070916_2 mitosis 12_48679260_CA_C
166 CAV2_3 305_TPCA-1_3 other 12_6952191_A_C / 1_24074187_A_G / 2_68818005_T_G
167 PRKAR2A_5 175_PAC-1_2 apop 13_37746457_TAA_TA / 7_73465568_GA_G / 7_77937691_AT_A / 12_107746489_GT_G / 6_136108863_GA_G
168 CDH3_1 344_THZ-2-49_3 cell_cyc 1_24074187_A_G
169 PCYOX1L_1 271_VNLG/124_3 chromatin 5_122946014_G_GT
170 RNF13_1 1054_Palbociclib_2 cell_cyc 10_69097096_G_A
171 CD7_2 205_Avagacestat_2 other 5_111103810_A_G / 5_111118983_A_G
172 ZDHHC20_2 190_Bleomycin_1 DNArep 21_38451144_T_G / 11_47588455_A_C
173 LGALS3_1 211_TL-2-105_3 erk_mapk 20_47169235_T_C
174 FANCD2_1 1054_Palbociclib_2 cell_cyc 5_161895646_GT_G
175 TLX2_1 344_THZ-2-49_3 cell_cyc 1_157833087_T_C
176 IFT122_1 1054_Palbociclib_2 cell_cyc 9_33798019_A_G
177 ZNF423_5 175_PAC-1_2 apop 3_9977055_TA_T / 7_77937691_AT_A / 21_32744756_GA_G / 11_63382198_CA_C / 9_120989554_CT_C
178 KDELR1_2 185_Linsitinib_2 igfr 17_62447686_C_T / X_49304797_C_G
179 UFM1_1 282_Pelitinib_2 egfr 8_7811967_A_G
180 ANKRD22_1 281_Alectinib_2 rtk 7_38349808_A_G
181 PLAGL1_3 1526_Refametinib_3 erk_mapk 11_118551711_A_G / 7_93426338_G_A / 16_28902389_G_T
182 ZAP70_5 205_Avagacestat_2 other 13_37746457_TAA_TA / 6_163478762_CT_C / 22_29978883_CT_C / 7_77937691_AT_A / 5_71545270_TA_T
183 OSBPL11_3 1014_Refametinib_2 erk_mapk 17_4896602_C_T / 10_122336546_A_C / 10_122336520_T_C
184 TSPAN7_2 205_Avagacestat_2 other 6_152444591_GA_G / 2_210663103_GTT_GT
185 SPAG7_1 1047_Nutlin-3a (-)_2 p53 20_63968004_C_T
186 ABCB10_1 1014_Refametinib_2 erk_mapk 3_52786995_A_G
187 WDR83_4 1236_UNC0638_3 chromatin 16_57460490_GA_G / 14_103670339_GT_G / 1_225147359_GT_G / 16_30280420_GA_G
188 SLC25A29_5 226_GSK1070916_2 mitosis 12_25215659_AT_A / 5_70067144_CA_C / 21_32744756_GA_G / 11_63382198_CA_C / 7_28494775_GT_G
189 SGPP1_1 1526_Refametinib_3 erk_mapk 1_153645034_CT_C
190 CD59_1 271_VNLG/124_3 chromatin 13_23593366_T_A
191 MRPS21_5 1011_Navitoclax_2 apop 1_148124171_A_G / 1_247841358_T_G / 3_197622346_A_C / 7_100884179_T_G / 11_72220933_A_C
192 ILF2_1 257_NPK76-II-72-1_3 mitosis 19_13993876_CT_C
193 NRM_1 1011_Navitoclax_2 apop 11_4082830_A_C
194 FEM1C_1 1378_Bleomycin(50uM)_1 DNArep 1_15443607_G_A
195 PRCP_1 190_Bleomycin_1 DNArep 3_53179641_T_C
196 P4HB_1 1526_Refametinib_3 erk_mapk 2_71427045_G_A
197 CD44_1 1498_Selumetinib_2 erk_mapk 8_132137720_G_A
198 DCTN4_1 249_Cabozantinib_1 rtk X_3271895_G_A
199 YIPF5_1 275_I-BET-762_3 chromatin 18_63655761_T_C
200 AGPAT2_1 1526_Refametinib_3 erk_mapk 21_25714604_C_A
201 FAM136A_1 1032_Afatinib_1 egfr 16_50711362_A_C
202 TSPAN32_5 271_VNLG/124_3 chromatin 22_45399045_C_A / 22_45383455_A_G / 22_45322160_A_G / 4_147906782_T_C / 9_32472897_A_G
203 PLA2G16_1 261_TL-1-85_3 other 11_71605554_A_C
204 MET_2 196_Phenformin_3 metabol 11_71605554_A_C / 19_39902109_T_G
205 TMEM97_1 281_Alectinib_2 rtk 2_113939939_A_G
206 ZNF839_1 176_IPA-3_3 cytoskeleton 10_70301448_T_G
207 ERMAP_4 1526_Refametinib_3 erk_mapk 4_25662622_G_A / 2_160137837_C_T / 10_111079134_C_A / 2_160138253_A_G
208 TMEM150A_1 1014_Refametinib_2 erk_mapk 10_88602550_CT_C
209 PDIA5_1 1526_Refametinib_3 erk_mapk 11_18534402_T_C
210 CLIP1_3 1378_Bleomycin(50uM)_1 DNArep 11_24976472_CTGTT_C / 7_1155657_T_TC / 7_1092820_C_T
211 NUDT2_1 55_A-770041_3 other 14_94592125_A_C
212 SMYD2_1 134_Etoposide_1 DNArep 6_26443625_C_A
213 TMPO_1 203_BMS-345541_3 other 10_69097096_G_A
214 ZC4H2_5 226_GSK1070916_2 mitosis 19_1057777_GA_G / 13_91728769_CA_C / 13_24781827_GTT_GT / 16_30280420_GA_G / 7_77937691_AT_A
215 TXLNB_1 1014_Refametinib_2 erk_mapk 20_56366031_C_T
216 CHID1_3 1014_Refametinib_2 erk_mapk 15_78939184_A_AG / 15_78922969_A_C / 1_53250744_G_A
217 TBXAS1_2 1526_Refametinib_3 erk_mapk 1_13104901_G_A / 1_13116020_T_C
218 KLHL25_5 226_GSK1070916_2 mitosis 12_48679260_CA_C / 3_129433338_GT_G / 13_97982483_AT_A / 6_70861991_TA_T / 6_43525297_GT_G
219 CSF3R_5 277_Linifanib_2 rtk 16_57082546_T_C / 9_137986862_A_C / 16_57081660_C_T / 17_7771466_C_T / 17_7801487_C_G
220 SEPHS1_1 182_Obatoclax Mesylate_2 apop 2_232087433_CT_C
221 TRAT1_3 205_Avagacestat_2 other 10_67956845_TA_T / 20_47180038_AT_A / 16_84013157_C_T
222 BET1_1 224_AS605240_3 pi3k 1_1638657_A_G
223 ZNF238_1 1026_Tanespimycin_2 other 2_151617472_C_A
224 BST1_1 1014_Refametinib_2 erk_mapk 3_75338856_G_A
225 CITED4_1 1014_Refametinib_2 erk_mapk 3_75338856_G_A
혈액암(blood) 약물에 대한 바이오 마커의 반응성 검증 결과
No. FRH Var_Exp(pval) Var_Drug(pval) Exp_Drug(pval) Ave_VarDrug(pval) Rank
1 MYB_5 2.44E-11 2.33E-06 / 2.99E-05 / 9.07E-05 / 0.000162263 / 0.000181347 / 0.000222215 / 0.00035849 / 0.000514476 / 0.000545979 / 0.000674184 / 0.000765635 / 0.000770681 / 0.001809532 / 0.001834875 / 0.002399212 / 0.002524974 / 0.002550614 / 0.003470781 / 0.003612549 / 0.003858986 / 0.005094315 / 0.006467757 / 0.006664862 / 0.007101459 / 0.009131449 / 0.009396282 9.43E-05 / 1.18E-09 / 0.000534893 / 1.91E-08 / 2.60E-05 / 2.14E-05 / 0.178381086 / 3.59E-08 / 0.002198223 / 5.01E-09 / 6.92E-07 / 0.003563123 / 2.90E-06 / 0.0012215 / 4.76E-07 / 5.58E-05 / 0.04742754 / 0.011052464 / 0.001638122 / 0.028671936 / 0.334605149 / 2.70E-05 / 0.120451258 / 0.000163666 / 6.58E-06 / 0.028639924 2.70E-03 26
2 CCND3_2 0.0000000001 4.077045608756939e-05 / 0.00024222551880903305 / 0.001033946011968038 / 0.007738992794998014 / 0.0011591447239658929 / 0.00039912025376145785 / 0.02164918938012539 / 6.767691357801751e-06 / 0.000284832520137907 / 0.012017653306794376 / 0.0002453692853096132 / 0.0005273716584544123 / 0.005671961091542384 1.3348349963172225e-09 / 2.806907767463066e-08 / 1.0352538568715997e-07 / 1.8603881635236497e-07 / 1.1627237502541528e-07 / 3.1401583771073866e-07 / 1.4513640953107782e-06 / 1.658411377465063e-05 / 3.739246289943189e-07 / 1.757546223859833e-06 / 7.270726435772972e-07 / 1.8069518974781594e-07 / 9.210108427954504e-07 0.003924411 13
3 CLEC11A_2 0.0000000001 0.0005697783607490941 / 0.014056110467957862 / 0.0041011587330335945 / 0.011850911896821052 / 0.0009698603317938078 / 0.04207757694014471 / 0.0027388104840193185 / 0.00017246675352488265 / 0.03592273895483884 / 0.03175705986170069 2.242207521501935e-07 / 8.305985309487528e-07 / 4.8336013623637535e-06 / 9.846343563173533e-08 / 6.35432916630242e-05 / 4.269555689878972e-05 / 8.205338044521348e-05 / 2.020761222821706e-05 / 3.783085835895955e-05 / 1.848382097554245e-05 0.014421647 10
4 SLFN11_1 0.0000014885 2.058410044027094e-07 / 3.2782204810649745e-06 / 0.0004160871569071042 / 6.63292779378419e-05 / 0.006637671888814827 / 0.0022180912856278046 / 0.018399047195112327 / 0.008405657307724725 / 6.561891568628848e-09 2.149510966621969e-13 / 1.511769414105504e-12 / 5.5112514063494236e-11 / 1.4108104414924931e-11 / 2.0143854426093352e-07 / 4.658955213551342e-08 / 8.06522811486229e-08 / 7.925927909364347e-07 / 2.303130551346628e-06 0.004016264 9
5 GLUL_1 0.0000002831 0.00023185717108361177 / 0.006750424182996093 / 0.0002804552471714009 / 0.0005780064318768233 / 0.013252364717981309 / 1.0437921127925209e-05 / 0.0007062900199205474 4.534423217653711e-06 / 3.2067677278063803e-07 / 1.3129666358688659e-07 / 2.6699938480633866e-07 / 2.004464466602968e-06 / 0.00014802121084993243 / 7.828884449821822e-06 0.003115691 7
6 ARRB1_1 0.0000033954 0.0002804552471714009 / 0.0005780064318768233 / 0.010567003405101198 / 0.014937099801101831 / 0.01674887186117834 / 1.0437921127925209e-05 / 0.00023185717108361177 1.4696888618625038e-06 / 3.112710641578339e-05 / 1.247822961432111e-06 / 3.477116300776317e-06 / 0.00011575707789856708 / 0.0008336548513620248 / 0.0016450159858039666 0.00619339 7
7 UBASH3B_1 0.0000018468 0.0002995789665935157 / 0.0040572780204219784 / 0.005622638162586019 / 0.0058415461692228185 / 0.012034946659617903 / 0.021088961594331778 / 0.01327523933544239 4.724411278108721e-08 / 4.074534670810025e-07 / 3.742229484811863e-08 / 1.929959476498321e-06 / 9.208079400238424e-07 / 1.5168095717056432e-05 / 0.00010044442526903786 0.008888598 7
8 TNFRSF1A_2 0.0000000156 0.006712933497164321 / 0.00734125603680501 / 0.03443695791574148 / 0.018289424799019176 / 0.0009354534478970254 / 0.03357668476840166 / 0.007912796162920774 4.5437268485007956e-12 / 9.62085159236817e-09 / 5.689408914135723e-10 / 2.0274308401802066e-09 / 8.235496674010025e-08 / 1.2678212837654556e-05 / 8.896726535766315e-06 0.015600787 7
9 FLT3_1 0.0000001451 0.003147802426563143 / 0.04222939169807093 / 0.02231188189092723 / 0.029744514791248327 / 0.028609215461963253 / 0.014219370494597181 / 0.014883090519715167 0.0012185301703030475 / 0.0002548917231763184 / 0.010959181924780034 / 2.4351732992736147e-06 / 5.5554978038046984e-05 / 0.0009499267638480247 / 0.013113311745609578 0.02216361 7
10 TAF3_1 0.0000001041 1.571192550615105e-05 / 1.941083369182502e-05 / 0.0005612205331984135 / 0.0014877407788245077 / 5.841226151846549e-05 / 0.0007872693710314749 1.0270513426028016e-06 / 2.275418199134362e-06 / 5.376973880229442e-07 / 5.440513967426541e-05 / 4.007754879249793e-05 / 9.814569472587485e-06 0.000488294 6
11 RNF169_1 0.0000003217 0.01436512323945228 / 0.0006014109163865767 / 0.0001378888342129313 / 0.0002929996205947111 / 0.007650609737897124 / 0.0005428574293301743 0.0010596490798711214 / 0.00033866528188749375 / 5.121947955378021e-05 / 5.927440166657884e-05 / 6.948929572951347e-06 / 2.3120988018089485e-05 0.003931815 6
12 AGTRAP_1 0.0000023662 0.0027034438550029654 / 0.0016457734962318454 / 0.014533062562870484 / 0.02599605804689892 / 0.0024801934991487765 / 0.009546895754403102 1.646452812514797e-07 / 5.834785414810817e-09 / 2.228307124314093e-06 / 5.569491755748062e-05 / 2.3571084667936895e-07 / 0.0003782361834351102 0.009484238 6
13 DDX60L_1 0.0000004163 0.008667427627946265 / 0.006966556160504672 / 0.002473974378703085 / 0.016468758578796875 / 0.004255262005017205 / 0.025751753175331515 2.1944492060454965e-10 / 8.933493156895685e-11 / 2.0506277272462366e-08 / 1.215047380695114e-10 / 7.747481723739867e-10 / 1.3299778330505356e-06 0.010763955 6
14 MARCH9_1 0.0000028687 0.008696629436037122 / 0.015715958080688867 / 0.014693978334844182 / 0.007641325545186426 / 0.01903807829299923 / 0.02673662083221299 2.0837934472912685e-10 / 3.483396562503217e-08 / 4.9563854817943744e-06 / 1.1230784085451434e-07 / 4.956418832931685e-07 / 6.827219227535627e-05 0.015420432 6
15 OSBPL5_1 0.0000008435 0.0261982361091171 / 0.030902579554522257 / 0.005200674803908244 / 0.01749894538092688 / 0.0006032976474312159 / 0.02092310744702267 5.453427993682317e-09 / 3.766985952770836e-07 / 1.2761924650567061e-06 / 7.72434990386913e-06 / 1.4070385044464016e-05 / 3.4211990088426983e-05 0.016887807 6
16 ZNF22_1 0.0003669254 0.004371760349727022 / 0.0099226754908213 / 0.010321671240407263 / 0.011325776736179346 / 0.044537859106021475 / 0.025680963996521974 2.5184177279829715e-06 / 1.636959244332829e-05 / 9.28253424535522e-06 / 2.0181236604145942e-05 / 1.6154147530836813e-08 / 1.1540056394143666e-05 0.017693451 6
17 DGAT1_3 0.0000000002 0.003920312673863002 / 0.033716279024290426 / 0.028856747132498983 / 0.001891302386162808 / 0.0334381808514423 / 0.04828281984464098 8.140369229025295e-09 / 5.289386858277019e-09 / 3.985757315136653e-06 / 1.144807405715584e-06 / 1.0254993066544188e-07 / 5.67274705848272e-07 0.025017607 6
18 ORMDL3_2 0.0000000026 0.0001300233129794514 / 0.00012978314275476224 / 0.0012778350943993954 / 0.0029565776361184853 / 7.156767789831989e-05 4.677646164059941e-05 / 1.7503293191137602e-05 / 0.00021751510293843788 / 0.0007155675311678111 / 0.0004230167122498104 0.000913157 5
19 ROPN1L_2 0.0000000992 0.0018394467371983382 / 0.00913487358238157 / 0.0049023855394268795 / 0.026316021782540434 / 0.0004368255106696828 1.65748500527577e-06 / 2.69948847247789e-06 / 3.4467469699377065e-06 / 8.914027666915662e-05 / 4.187857920242108e-05 0.008525911 5
20 MSI2_1 0.0000007794 0.0002529667144490502 / 0.00036391652177154756 / 0.02345731242786629 / 0.019126121819567174 / 0.0033080493995101515 7.391397953437064e-07 / 4.9426454303194644e-08 / 1.2647772425190535e-05 / 1.2578560206261788e-05 / 0.0003891280853340393 0.009301673 5
21 PSTPIP2_2 0.0000011641 0.01858959254693148 / 0.0057681381434131025 / 0.015399266745073165 / 0.01166420660727075 / 0.004242395710111552 6.507094545128767e-09 / 1.7105362633772053e-06 / 8.11163443332903e-09 / 8.384249213928925e-09 / 2.7206056643566975e-06 0.01113272 5
22 MYL6B_1 0.0000017698 0.013119151423196779 / 0.012200296617999914 / 0.02306053904486267 / 0.011416714879054282 / 0.01303162671001627 1.3311228115309853e-10 / 2.1189280513945988e-08 / 2.608386936275246e-06 / 4.4163387400701993e-07 / 1.2403225638581886e-06 0.014565666 5
23 LPAR6_2 0.0000010413 0.04483307027122483 / 0.016219042044394588 / 0.016746868284220093 / 0.00486964278014844 / 0.011545690725925754 3.55398091991154e-07 / 3.727072342882139e-06 / 8.612792966957608e-06 / 2.5049632841227237e-05 / 0.0002242378619733357 0.018842863 5
24 RIPK2_5 0.0000090083 0.02265948210195236 / 0.035801285983055375 / 0.013949514732498905 / 0.03916661845542834 / 0.010906005384287334 2.1349289386986835e-07 / 6.970901169252273e-06 / 0.0001261364550401567 / 0.000139252106012186 / 0.0001754023039229962 0.024496581 5
25 KIF15_1 0.0000003279 0.0001767131207877772 / 0.0020841717587245586 / 0.004354818985686167 / 0.003594625784570769 3.8166356839184545e-08 / 7.55812749192087e-08 / 8.424093350919768e-09 / 1.7417317886126239e-06 0.002552582 4
26 ATP11A_2 0.0000000003 0.0020192776408069777 / 0.0014905987749008023 / 0.013592511172070427 / 0.011492354840434907 3.060704654994384e-08 / 1.3622595470762118e-06 / 1.1997422693515186e-05 / 2.3355709465331877e-05 0.007148686 4
27 ZYX_1_9 0.0002544084 0.018753885801507886 / 0.005311083771261927 / 0.006409025340802752 / 0.005160774238426144 4.184364793482633e-08 / 2.790592162598525e-08 / 4.0166122353119465e-05 / 1.8565339769963503e-05 0.008908692 4
28 SNRPG_5_5 0.0000089357 0.007921660193554354 / 0.02167583393151509 / 0.010388347521304256 / 0.004658316663498735 3.551868821203453e-05 / 0.00013168055697875434 / 6.548534863709185e-06 / 0.0005681263502070304 0.01116104 4
29 RABGAP1_4_4 0.0000000240 9.003720907011053e-06 / 3.3390115236034044e-05 / 0.00010269468011156112 / 0.047149137178743444 2.8234052288359836e-11 / 1.0277712264139365e-09 / 4.49119651999139e-09 / 2.1963432700833613e-06 0.011823556 4
30 AEBP1_5_4 0.0000000706 0.036562724183920495 / 0.0028825516275127186 / 0.00160056713944595 / 0.011492031900646014 1.9554526130426222e-07 / 1.552879261624138e-05 / 4.179984189724783e-07 / 8.30585388888977e-05 0.013134469 4
31 HNRNPA0_5_7 0.0000000001 0.02460227458303824 / 0.004665409573481128 / 0.030772288525987988 / 0.001787886444312416 6.020361445492525e-07 / 1.741544026523412e-07 / 5.73570311140249e-07 / 6.770166211380507e-06 0.015456965 4
32 PVRL2_1_15 0.0040605369 0.009602522264793944 / 0.009289808589253353 / 0.018424979456259774 / 0.024543614212947564 1.124934929019874e-11 / 8.232216311317465e-10 / 1.9664830084576235e-07 / 4.469619906576272e-09 0.015465231 4
33 KIAA1377_1_4 0.0000081593 0.018039249363489208 / 0.024808081702847627 / 0.015360074710325671 / 0.006240332233062281 7.596479317713833e-09 / 6.788792995710976e-08 / 1.35168996872219e-07 / 2.1659140645524504e-08 0.016111935 4
34 THEM4_5_4 0.0000000056 0.007883092210604252 / 0.045211602878352866 / 0.013149940565499176 / 0.005780083414189651 4.830559480901911e-08 / 7.6434613644282e-08 / 1.0166377279715499e-05 / 5.88015987182058e-07 0.01800618 4
35 RBM15B_4_4 0.0000007681 0.0009381311035088946 / 0.03970456788745093 / 0.028253326379734534 / 0.006515747132785524 1.3038025544377534e-07 / 2.059062830566604e-07 / 4.983244116392506e-06 / 6.51433835861991e-05 0.018852943 4
36 C10orf11_1_7 0.0003082937 0.02543028371249526 / 0.04598785527902361 / 0.015049388659828227 / 0.023622920144404418 7.259417399792894e-07 / 7.365037376695162e-06 / 2.047194651689395e-05 / 0.0002797495873085723 0.027522612 4
37 NSMAF_1_7 0.0000032686 0.022251914845713937 / 0.04748951355240249 / 0.048345822890961225 / 0.01793479538407506 2.9254934132272395e-07 / 6.623060722446782e-06 / 5.831321946385646e-07 / 0.0022213483241615155 0.034005512 4
38 FRAT2_2_9 0.0000008562 0.0469875036346009 / 0.03110964092628252 / 0.028109447152411662 / 0.04417620834797813 3.3044879183409916e-06 / 9.1345152872844e-06 / 8.429737657625968e-06 / 1.855611509886761e-05 0.0375957 4
39 LRPAP1_2_3 0.0000000010 5.8572126941774705e-06 / 3.043966989607747e-06 / 4.7114539866525214e-06 1.9971265139787018e-07 / 8.389633993572189e-07 / 4.782132344940121e-05 4.53754E-06 3
40 PRAM1_3_3 0.0000000000 7.723544457794067e-05 / 0.00043689278876896613 / 6.689338676878303e-05 0.00010570433563924172 / 0.007095334821012586 / 0.00012642089180450603 0.000193674 3
41 RAG1_2_3 0.0000000001 0.0005257240065993557 / 0.0002394716728524391 / 0.0025629535017791943 5.592836211795487e-07 / 4.514859891307818e-06 / 0.00031448434878023827 0.001109383 3
42 CARHSP1_2_3 0.0000000916 7.622564649516217e-05 / 0.0009833215694022874 / 0.0024720664729962283 2.124059305243635e-07 / 0.00011446446711497937 / 7.575581180621143e-05 0.001177205 3
43 MBLAC1_1_3 0.0000002897 0.001629254700856046 / 0.007145353467565649 / 0.003740996699493107 2.6740655179081655e-06 / 5.483995787755592e-05 / 9.450515390044369e-06 0.004171868 3
44 RAG2_3_4 0.0000000033 0.006629188877801916 / 0.0035201246516142408 / 0.007903236560929908 9.394932445113252e-06 / 6.847563888114024e-07 / 3.436655016403447e-06 0.006017517 3
45 HNMT_1_4 0.0000109002 0.01445558317701132 / 0.002106973677295091 / 0.0051161594672994425 0.0009692764104023793 / 0.003012779171399397 / 0.0024376724564066005 0.007226239 3
46 KCTD7_2_5 0.0000002604 0.020616294446739954 / 0.00021206125966908608 / 0.0009033836310563283 8.885033400689205e-08 / 2.389820509715415e-08 / 1.552864015973841e-06 0.007243913 3
47 GSN_1_6 0.0000451573 0.018753885801507886 / 0.005160774238426144 / 0.005311083771261927 1.4722017530591616e-07 / 2.9874753250046506e-06 / 0.0002124927996391344 0.009741915 3
48 CBFB_2_5 0.0000000001 0.003275583453177208 / 0.011330483320304221 / 0.01982909497763039 2.0245259136355526e-08 / 1.1456344413276593e-07 / 2.816265834361234e-06 0.011478387 3
49 FBXO33_1_4 0.0000001371 0.0023176777492038073 / 0.0077384325604461434 / 0.028530012205593615 1.072142034599158e-06 / 5.345226496779758e-06 / 8.792028909123797e-05 0.012862041 3
50 ZBED4_2_4 0.0000000002 0.00012909510564440324 / 0.027672452276552212 / 0.021025463475859662 9.434784549401446e-08 / 1.0143923768921633e-06 / 4.495391600951897e-06 0.01627567 3
51 COPS8_5_6 0.0000043601 0.0031977499264920816 / 0.0058949672009652055 / 0.0415421191636228 6.858069673230018e-10 / 4.518917447441741e-08 / 2.2871232096910657e-06 0.016878279 3
52 ISG20_1_12 0.0000001188 0.035870034304549374 / 0.006915099173258228 / 0.011599763066790982 4.0742030661470875e-09 / 3.5704180408306135e-05 / 2.6235380954232833e-06 0.018128299 3
53 LGALS12_3_4 0.0000000247 0.003840056352113353 / 0.04492920892897124 / 0.006327629664955956 1.3156520171567348e-06 / 2.8564954858549742e-05 / 1.2400627667338633e-05 0.018365632 3
54 SNRNP48_5_3 0.0000000018 0.010494026299769539 / 0.043808945731610247 / 0.0014402699590059412 2.99777252070361e-08 / 9.372440209809473e-07 / 1.6303080292790598e-06 0.018581081 3
55 VPS37C_3_4 0.0000000002 0.015575058031697179 / 0.022954263288630178 / 0.019211836869592394 1.1893807531811264e-07 / 4.436107889122841e-07 / 2.596755422338286e-05 0.019247053 3
56 ATP6V0A1_1_3 0.0000019232 0.000953280912166266 / 0.048984014938993056 / 0.009090139199551346 3.96290085102306e-06 / 5.2636828189880915e-05 / 2.713261376319351e-06 0.019675812 3
57 HEATR5A_5_6 0.0000002878 0.007823565564916568 / 0.0292814900476121 / 0.02260169832848745 8.824452322000626e-09 / 8.736451088889874e-07 / 3.993788450977646e-06 0.019902251 3
58 ENG_2_8 0.0000000000 0.03439309599730442 / 0.026001527500775657 / 0.0004074623263257791 3.7930066913887975e-05 / 2.6178770339186957e-06 / 3.208634906990993e-05 0.020267362 3
59 USF1_5_7 0.0000000001 0.021841208862304992 / 0.020652548829715695 / 0.021917069763045867 7.175376098186409e-08 / 2.6998472948345092e-08 / 3.909927527606591e-07 0.021470276 3
60 GRB10_2_11 0.0000185139 0.01872961470434043 / 0.02675787024949966 / 0.02145205112846333 1.2669785337002742e-06 / 3.145604382649769e-05 / 0.003268778879566519 0.022313179 3
61 ZNF415_2_4 0.0000000549 0.034523433022212606 / 0.002626392249292539 / 0.03171232908110631 0.00011739915632689058 / 0.00032821497481615343 / 0.0006546049761514156 0.022954051 3
62 DMTF1_1_4 0.0000031099 0.014324360736687866 / 0.014925670621200341 / 0.04696641107757261 1.4288355402449756e-08 / 1.4596250772642315e-06 / 5.309179790067734e-07 0.025405481 3
63 MSL2_4_5 0.0000015252 0.037843536087373564 / 0.028245718557519638 / 0.010417492228432875 8.258866166846628e-08 / 0.0002798921759421857 / 1.2286864638985527e-05 0.025502249 3
64 ATP7B_2_6 0.0000857095 0.019438518423424804 / 0.04009632870085458 / 0.019672456709775226 0.005743135091223456 / 0.0021129104763862407 / 0.00504181900162891 0.026402435 3
65 MANBAL_1_5 0.0010263664 0.04759200231032889 / 0.013410196167242377 / 0.021153975401583373 0.0006029756140517701 / 0.00041293727100713963 / 0.0005679619453748995 0.027385391 3
66 STOX1_1_3 0.0000006884 0.03863925234050396 / 0.03290414475660668 / 0.03755706426028869 3.498492394676035e-07 / 3.760551753407323e-07 / 2.1838711309964997e-05 0.03636682 3
67 PRKCB_2_4 0.0036722126 0.03636552435344791 / 0.0455393445167841 / 0.028719427176232087 0.0017342974389574256 / 0.0002954473217666082 / 0.0019265906505422808 0.036874765 3
68 PNPLA8_3_5 0.0007762216 0.042906002207961834 / 0.03376346011476386 / 0.04533268492631154 1.8682120741176118e-07 / 3.889932908773882e-08 / 9.103372671114004e-06 0.040667382 3
69 ACCS_3_2 0.0000000228 0.001351396866557077 / 0.0010059530260990539 4.958979360917343e-05 / 0.0023766001705639063 0.001178675 2
70 BANP_1_2 0.0000005192 0.0019949596708715915 / 0.0016405254782622762 1.8954349923575262e-08 / 2.9663347375425656e-07 0.001817743 2
71 ARID1A_2_3 0.0000370373 0.0002225245598561803 / 0.003462048449780649 2.8835181082720374e-06 / 8.852299874117299e-06 0.001842287 2
72 ELOVL5_1_4 0.0000080768 0.0039737550720910855 / 0.0005677614392890738 1.767738685972929e-05 / 5.339450136972672e-05 0.002270758 2
73 N4BP2_5_2 0.0000006959 0.0015260933937112297 / 0.0030693630789256784 8.782349802931962e-08 / 1.8514757097012648e-06 0.002297728 2
74 LIMS2_5_3 0.0000000063 0.0016929672723561087 / 0.008211724439767342 0.0016526205911910397 / 0.00010998980798238088 0.004952346 2
75 DPCD_1_2 0.0001195622 0.010348808383695646 / 0.0010576116241639605 3.4139161518097934e-06 / 5.8072556519062024e-05 0.00570321 2
76 KATNB1_5_2 0.0000003099 0.0019502509185472647 / 0.011870363561574568 6.469316636849928e-07 / 1.4319474206641112e-06 0.006910307 2
77 RBM18_1_3 0.0000183263 0.01202180554894753 / 0.0035996788619062025 2.314655750329529e-05 / 1.6273301545995376e-05 0.007810742 2
78 EWSR1_1_2 0.0000001571 0.012034946659617903 / 0.0040572780204219784 4.353930633746647e-07 / 1.4940958130887165e-07 0.008046112 2
79 SDC4_1_5 0.0234952285 0.012910722002948388 / 0.003241368623522047 0.0023789084931403904 / 2.15445169218155e-05 0.008076045 2
80 LCK_5_3 0.0000000635 0.008161592461102153 / 0.008111725160704844 5.0045516393587565e-08 / 2.5329814927720417e-06 0.008136659 2
81 GNA15_1_9 0.0000088925 0.0025023165322416653 / 0.015816246241733566 1.2297735264773097e-09 / 2.212465069137835e-05 0.009159281 2
82 S1PR2_2_8 0.0000000000 0.019132559438094155 / 3.0373671784422295e-05 8.259862596669298e-06 / 3.850434675370876e-06 0.009581467 2
83 SOX4_2_2 0.0000001046 0.0027896864342722566 / 0.018314702453390137 1.3593400126131383e-06 / 3.4858545482237707e-06 0.010552194 2
84 MPP1_1_19 0.0000010744 0.0025023165322416653 / 0.019031746930740782 6.468408975112741e-07 / 4.501092888023762e-06 0.010767032 2
85 TRIM26_1_5 0.0000259348 0.005311083771261927 / 0.018753885801507886 2.1060691141971387e-05 / 8.874237350648491e-05 0.012032485 2
86 NRN1_2_2 0.0000003469 0.011538246690417763 / 0.013237230739493226 4.568675707352792e-05 / 3.561238367689432e-05 0.012387739 2
87 PHACTR2_1_4 0.0000005718 0.023477467429053465 / 0.0031820555262817535 8.883753710042578e-09 / 3.719669014236788e-08 0.013329761 2
88 TRAF3IP2_2_2 0.0000002512 0.0007576193165839696 / 0.027287848272635487 6.910884434287362e-05 / 0.0005161273618227694 0.014022734 2
89 MLF1IP_1_2 0.0000000269 0.01425257865031356 / 0.013908722253004258 2.3242551216769015e-07 / 2.032446141420201e-07 0.01408065 2
90 PELI2_5_7 0.0000007941 0.024350309684056323 / 0.0040259990419718224 1.6694115297250117e-05 / 4.29829826110023e-06 0.014188154 2
91 HNRNPA1L2_1_2 0.0013250663 0.011811366692668503 / 0.01996564314234407 6.032224635469657e-06 / 0.00022917080156904956 0.015888505 2
92 BCL11B_5_3 0.0000002152 0.0010839847636384084 / 0.0314544685608876 1.5333271595229285e-05 / 5.898660325189134e-05 0.016269227 2
93 TTF1_5_6 0.0000000000 0.029170441459925932 / 0.005632866448663831 5.197029616318252e-06 / 3.552041331603543e-05 0.017401654 2
94 SKA3_1_2 0.0000017003 0.02944327994687945 / 0.006711372368467916 7.293595674464534e-07 / 6.073859065512907e-06 0.018077326 2
95 ECI1_1_2 0.0000229019 0.035232086909202764 / 0.004224402787232246 0.0006535889942974735 / 1.0760030207436584e-05 0.019728245 2
96 LAPTM4B_1_8 0.0005057964 0.038858943917955066 / 0.0026332591769253765 8.316897145333996e-07 / 0.0026794799237590664 0.020746102 2
97 C11orf74_4_5 0.0000166404 0.0065634419527186095 / 0.035907170503621015 2.3323526700006173e-07 / 3.9706288089173614e-08 0.021235306 2
98 RNF24_1_12 0.0000007106 0.035870034304549374 / 0.006915099173258228 7.35322340702987e-10 / 2.1643712587488395e-06 0.021392567 2
99 CRB3_1_4 0.0001229934 0.0007511098393260164 / 0.04383341877435241 0.003519521269349817 / 0.00041067349827126156 0.022292264 2
100 CNTROB_5_3 0.0000000247 0.039985574714404205 / 0.006604515441249478 2.807079453207472e-06 / 6.0843943238096606e-06 0.023295045 2
101 KIAA1967_5_2 0.0000000000 0.03731581709317308 / 0.012775853621628915 5.8098057666508814e-05 / 1.4846660294438575e-05 0.025045835 2
102 KRT10_1_3 0.0000036294 0.0026276752303615626 / 0.04816709797976521 2.3292547237816868e-07 / 1.1196213690475162e-05 0.025397387 2
103 VIT_1_2 0.0000022102 0.029787982806896113 / 0.032221265722000465 0.00017866575515019837 / 0.0002927226669085562 0.031004624 2
104 TMEM173_2_7 0.0000013775 0.04752560036471882 / 0.021645143900361517 9.96917291837022e-10 / 3.7449827724309687e-05 0.034585372 2
105 SGCB_1_3 0.0000001520 0.04565488150522094 / 0.02362203677270414 1.1745686994413256e-07 / 2.146978330026032e-06 0.034638459 2
106 DTD1_3_4 0.0000046923 0.04395039131441785 / 0.025938330717151792 2.2711346209436874e-06 / 5.0656566660967563e-05 0.034944361 2
107 DYSF_1_3 0.0000126202 0.0339445086192224 / 0.03749998396549492 1.097257076002153e-06 / 3.4300052428458304e-05 0.035722246 2
108 AP2S1_1_3 0.0000000192 0.04966114977300441 / 0.025208249293274098 9.67952519324101e-06 / 5.812467299823981e-06 0.0374347 2
109 EMILIN2_1_11 0.0000004298 0.035870034304549374 / 0.04080808705746035 3.9151610584341596e-05 / 0.0034531579985310175 0.038339061 2
110 SLC38A1_1_6 0.0000051639 0.04291927548525659 / 0.04100450439141127 0.00021587157297136373 / 7.315015547583871e-06 0.04196189 2
111 SGSM2_4_1 0.0000000000 1.8562520247073517e-06 1.2613994263920118e-05 1.85625E-06 1
112 ADAM15_1_1 0.0000043982 2.1108944769046428e-05 4.681342411309229e-05 2.11089E-05 1
113 JPH1_2_1 0.0000000278 7.575574348900015e-05 3.941680513177924e-06 7.57557E-05 1
114 S100A8_1_3 0.0000014212 0.00016898721560974943 0.00029401372690121037 0.000168987 1
115 SQSTM1_2_1 0.0000005259 0.00017867345021532058 9.669186962307088e-08 0.000178673 1
116 ANXA2_1_1 0.0002075934 0.0006183619071556604 6.009170462268738e-07 0.000618362 1
117 CMBL_1_2 0.0000903757 0.0006632986409284882 0.0009716339098724625 0.000663299 1
118 CABLES2_1_1 0.0000005356 0.0009735838558541434 1.5864345356463386e-06 0.000973584 1
119 NDST3_2_1 0.0001935195 0.0013385816312795275 0.004242951596879371 0.001338582 1
120 LMNA_1_1 0.0001346708 0.0013680275764369084 1.8919816110190497e-07 0.001368028 1
121 SP1_5_1 0.0000000097 0.0016246578528363023 0.003568784039880526 0.001624658 1
122 CDCA7_1_2 0.0000002357 0.001651752731778548 3.2201603349527115e-08 0.001651753 1
123 NFYB_1_1 0.0000079306 0.001651752731778548 2.9900676055211447e-06 0.001651753 1
124 SLFN5_2_1 0.0000000019 0.0019030049715582106 1.6941578744438862e-06 0.001903005 1
125 CREG1_3_1 0.0000000008 0.002054415410594919 7.20016447767814e-08 0.002054415 1
126 DAD1_1_1 0.0000006548 0.0023044700596710713 2.075870685180039e-05 0.00230447 1
127 SURF4_1_4 0.0001169460 0.0023462063828761834 2.694050289871364e-06 0.002346206 1
128 CDK6_1_1 0.0000006851 0.0025023165322416653 4.988905197611986e-08 0.002502317 1
129 TBCD_5_1 0.0000000036 0.002561276140915946 2.9892584316614904e-05 0.002561276 1
130 FLRT3_1_1 0.0002800458 0.002583315109010803 5.49167223817782e-07 0.002583315 1
131 FUCA2_2_1 0.0000025095 0.002692404935612982 1.2127488828322545e-08 0.002692405 1
132 MAPK7_1_1 0.0000080829 0.0027910840567973052 3.572472659968713e-06 0.002791084 1
133 IER3_1_1 0.0000013686 0.003048257034885675 4.950876200499383e-07 0.003048257 1
134 U2AF1_1_1 0.0000711501 0.0034457838678580263 4.61837154254303e-05 0.003445784 1
135 PLA2G12A_1_3 0.0000038708 0.0037441061510198473 2.729672667763293e-06 0.003744106 1
136 CBX2_2_1 0.0000000018 0.004184305915812207 5.9615623663426e-06 0.004184306 1
137 MGAT4A_5_1 0.0000000380 0.004222683731586138 8.335124351148404e-06 0.004222684 1
138 STARD10_1_1 0.0000111851 0.004248732743058664 1.7842777216078496e-05 0.004248733 1
139 CSRNP2_1_1 0.0006867668 0.004513557106243546 0.0027185421381640293 0.004513557 1
140 DOK2_2_1 0.0000003678 0.004572328568472603 1.1556890898941218e-07 0.004572329 1
141 VOPP1_1_1 0.0000001536 0.004906926404956519 6.909057066591582e-07 0.004906926 1
142 PLOD1_1_1 0.0000003727 0.005173685415892114 3.142318025848709e-07 0.005173685 1
143 C3AR1_1_1 0.0000020129 0.005257465843641482 2.3396828250233102e-05 0.005257466 1
144 CYSLTR1_1_1 0.0000173361 0.005311083771261927 4.033605569704644e-05 0.005311084 1
145 S100A6_1_1 0.0000725809 0.005362813680576461 5.537142752723009e-07 0.005362814 1
146 ZADH2_1_1 0.0000007439 0.005446188106227207 4.5754730268930877e-07 0.005446188 1
147 EXOSC9_5_2 0.0000000031 0.005557108169871316 0.0008987664165136352 0.005557108 1
148 ZC3H4_2_1 0.0000015162 0.0056341770524356806 2.473933719190643e-06 0.005634177 1
149 BARD1_1_2 0.0001823376 0.006165167235416857 1.190027150355448e-06 0.006165167 1
150 MCL1_1_1 0.0000001874 0.007100868378374273 4.0192784636893195e-10 0.007100868 1
151 NINL_3_4 0.0002849953 0.0075283603267041295 0.00041052511652349915 0.00752836 1
152 HYI_5_1 0.0000017676 0.0075586596774093046 1.819350673029577e-06 0.00755866 1
153 USP49_1_1 0.0001312429 0.008755239263851211 3.964656691897526e-06 0.008755239 1
154 EPB41_1_3 0.0001006328 0.009034882970510456 0.00013511214683115084 0.009034883 1
155 NFAM1_1_1 0.0022752255 0.00930978531173234 0.002292669227147625 0.009309785 1
156 SIVA1_5_1 0.0000000190 0.00976422285866606 7.911319869760405e-07 0.009764223 1
157 LRG1_1_2 0.0000001990 0.009927973270752382 2.608540917049233e-06 0.009927973 1
158 TMPRSS15_1 0.0006841749 0.01024047346065129 0.0015664204162032947 0.010240473 1
159 G0S2_1 0.0000299702 0.010257439205265872 8.408868136136204e-05 0.010257439 1
160 PPIP5K2_2 0.0000000004 0.010428331358146754 3.5879660652504166e-05 0.010428331 1
161 AGPAT3_4 0.0000001930 0.012409468524965496 5.951529459390704e-06 0.012409469 1
162 AS3MT_5 0.0000000636 0.012507967443150024 5.2069842035903486e-05 0.012507967 1
163 PIK3R3_1 0.0000004378 0.012693846370002933 1.1134112040621844e-05 0.012693846 1
164 CRY1_2 0.0000000015 0.01273908719327046 1.0364125026792716e-05 0.012739087 1
165 ZNF367_1 0.0000007429 0.012817165427214991 1.6554871434804345e-06 0.012817165 1
166 CAV2_3 0.0000900165 0.013003562519067686 0.0003165314040118799 0.013003563 1
167 PRKAR2A_5 0.0000000095 0.01304625461905942 1.165198476893287e-06 0.013046255 1
168 CDH3_1 0.0045171197 0.013410196167242377 0.0007156791563689302 0.013410196 1
169 PCYOX1L_1 0.0000134838 0.013753446987297501 1.9648507707958793e-05 0.013753447 1
170 RNF13_1 0.0000015479 0.01425257865031356 1.4173074929245687e-06 0.014252579 1
171 CD7_2 0.0000009350 0.01439564075722508 7.429143195372626e-05 0.014395641 1
172 ZDHHC20_2 0.0001740391 0.015206312141533855 4.602813943558735e-05 0.015206312 1
173 LGALS3_1 0.0000060213 0.015392940222320921 1.0628836539660367e-05 0.01539294 1
174 FANCD2_1 0.0000121545 0.015451637722969586 1.8831841564871015e-06 0.015451638 1
175 TLX2_1 0.0000038270 0.01579251142156246 0.00030858470095783614 0.015792511 1
176 IFT122_1 0.0000002512 0.015816246241733566 1.0290413092804304e-06 0.015816246 1
177 ZNF423_5 0.0000000005 0.01687645691903394 6.82889444974133e-05 0.016876457 1
178 KDELR1_2 0.0000093509 0.017039557735435966 0.0033303362491578807 0.017039558 1
179 UFM1_1 0.0000305210 0.01740310378263097 1.2418583024568846e-07 0.017403104 1
180 ANKRD22_1 0.0041854861 0.018007630833331033 0.03752163881197765 0.018007631 1
181 PLAGL1_3 0.0000021368 0.018069182178099105 3.851073571966146e-09 0.018069182 1
182 ZAP70_5 0.0000000009 0.018364208164662808 6.653729445177915e-06 0.018364208 1
183 OSBPL11_3 0.0000067843 0.018433344261519963 9.808098956813373e-09 0.018433344 1
184 TSPAN7_2 0.0004599184 0.018664165174459613 0.0021706260770740027 0.018664165 1
185 SPAG7_1 0.0000103437 0.01887978871098741 3.5786939909329174e-07 0.018879789 1
186 ABCB10_1 0.0000008268 0.019394963522372948 7.395897405399312e-06 0.019394964 1
187 WDR83_4 0.0000057993 0.019553853323608723 0.0007136717421366572 0.019553853 1
188 SLC25A29_5 0.0000000015 0.019638512683722072 9.869448477453816e-08 0.019638513 1
189 SGPP1_1 0.0000025587 0.020929857770881414 2.0298643448524998e-06 0.020929858 1
190 CD59_1 0.0000068828 0.021559533703573927 0.001648922456290617 0.021559534 1
191 MRPS21_5 0.0077373847 0.021700322664243165 9.63985905023122e-07 0.021700323 1
192 ILF2_1 0.0000000252 0.02183529105408133 3.091305085273976e-06 0.021835291 1
193 NRM_1 0.0002687490 0.022253050272657 2.0382718096255757e-09 0.02225305 1
194 FEM1C_1 0.0000014517 0.02227664632042583 8.589759094000804e-06 0.022276646 1
195 PRCP_1 0.0000000056 0.0230304550081597 2.1961723373343916e-07 0.023030455 1
196 P4HB_1 0.0000003568 0.02341318363108619 2.8084943956360846e-10 0.023413184 1
197 CD44_1 0.0000359903 0.023548564177701903 1.6066512112185574e-09 0.023548564 1
198 DCTN4_1 0.0013385549 0.024489122777067992 0.019368696851182407 0.024489123 1
199 YIPF5_1 0.0000060349 0.026730236331654417 1.0541687156357308e-06 0.026730236 1
200 AGPAT2_1 0.0000002107 0.026889530537036167 1.7713923094852022e-07 0.026889531 1
201 FAM136A_1 0.0006422807 0.028051819441664617 0.002488725830315593 0.028051819 1
202 TSPAN32_5 0.0000000000 0.02866197022141713 5.259717320638688e-06 0.02866197 1
203 PLA2G16_1 0.0003081786 0.02897405027367459 2.0665812391610075e-06 0.02897405 1
204 MET_2 0.0000285645 0.030192710022355414 0.00379589859681431 0.03019271 1
205 TMEM97_1 0.0036145788 0.03026262122509119 0.00021306559827421171 0.030262621 1
206 ZNF839_1 0.0000001711 0.030726289078901264 1.5879232684994666e-05 0.030726289 1
207 ERMAP_4 0.0001168108 0.031146240127524386 6.298967979200791e-05 0.03114624 1
208 TMEM150A_1 0.0000043452 0.03197682912178042 1.628398621899164e-05 0.031976829 1
209 PDIA5_1 0.0000034458 0.03351303270628667 2.3191823260124111e-10 0.033513033 1
210 CLIP1_3 0.0000001166 0.03429726403676071 4.469910794620894e-06 0.034297264 1
211 NUDT2_1 0.0000159662 0.034635799638304134 1.3986302087232156e-05 0.0346358 1
212 SMYD2_1 0.0000077856 0.03730228706011286 1.2971961011563423e-05 0.037302287 1
213 TMPO_1 0.0000008966 0.03798708635473315 9.272936461577683e-05 0.037987086 1
214 ZC4H2_5 0.0000000001 0.03821396773041524 3.364502202047952e-05 0.038213968 1
215 TXLNB_1 0.0063084330 0.038858943917955066 3.4406524050829844e-08 0.038858944 1
216 CHID1_3 0.0000000038 0.038921368031173256 1.7696631517095603e-08 0.038921368 1
217 TBXAS1_2 0.0001000498 0.03912053365002339 0.00017683963886805498 0.039120534 1
218 KLHL25_5 0.0000000143 0.04196676056691442 1.7560089108082686e-05 0.041966761 1
219 CSF3R_5 0.0000000304 0.04250513375736285 0.00017631047010437925 0.042505134 1
220 SEPHS1_1 0.0000222248 0.0450636464624055 6.469551154776827e-06 0.045063646 1
221 TRAT1_3 0.0000000000 0.04551857731992099 0.00013370660602496452 0.045518577 1
222 BET1_1 0.0000000254 0.0465608957106569 1.9024554960722768e-07 0.046560896 1
223 ZNF238_1 0.0000006050 0.046847268071909955 7.35354402710928e-05 0.046847268 1
224 BST1_1 0.0000370830 0.04931613832873068 0.0025410513361841546 0.049316138 1
225 CITED4_1 0.0000331218 0.04931613832873068 5.1719881815858375e-05 0.049316138 1
[표 4]에는 여성암(breast, ovary) 약물에 연관된 FRH 들과, 이와 연관된 여성암 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 5] 에는 [표 4]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(Pvlaue)값을 의미하는 것으로, [표 4]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 4]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 여성암 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 27에는 표 4에 기재된 바이오마커들 중 주요 바이오마커들의 여성암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 28에는 주요 바이오마커들에 의해 발현된 유전자들과 여성암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
여성암(breast, ovary) 약물에 대한 반응성 바이오 마커
No. FRH Drug DrugType Var(마커)
1 IRX5_3 1526_RDEA119 (rescreen) / 1242_(5Z)-7-Oxozeaenol / 1372_Trametinib / 1498_AZD6244 / 1014_RDEA119 / 1378_Bleomycin(50uM) / 1005_Cisplatin / 1019_Bosutinib / 165_DMOG / 1015_CI-1040 / 1020_Lenalidomide / 1371_PLX4720(rescreen) / 155_AP-24534 / 1062_AZD6244 / 1495_Olaparib / 1006_Cytarabine / 1060_PD-0325901 / 1013_Nilotinib / 1018_ABT-888 / 1268_XAV 939 / 1003_Camptothecin / 262_VX-11e / 1037_BX-795 / 1024_CEP-701 / 1017_Olaparib / 1243_piperlongumine / 1022_AZD7762 / 1375_Temozolomide / 1043_JNK Inhibitor VIII / 226_GSK1070916 / 228_KIN001-102 / 1091_BMS-536924 / 308_XL-880 / 1264_SGC0946 / 1494_SN-38 erk_mapk / other / erk_mapk / erk_mapk / erk_mapk / DNArep / DNArep / abl / other / erk_mapk / other / erk_mapk / abl / erk_mapk / g_integrity / DNArep / erk_mapk / abl / g_integrity / wnt / DNArep / erk_mapk / other / rtk / g_integrity / other / g_integrity / DNArep / jnk_p38 / mitosis / pi3k / igfr / rtk / chromatin / DNArep 1_13248174_T_C / 16_85071785_A_G / 9_34371054_A_C
2 IRX5_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 155_Ponatinib_2 / 1378_Bleomycin(50uM)_1 / 165_DMOG_3 / 1014_Refametinib_2 / 1242_(5Z)-7-Oxozeaenol_3 / 159_HG6-64-1_3 erk_mapk / erk_mapk / erk_mapk / abl / DNArep / other / erk_mapk / other / erk_mapk 1_13248174_T_C
3 CMIP_1 1526_Refametinib_3 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1378_Bleomycin(50uM)_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / DNArep 16_85071785_A_G
4 PREX1_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 155_Ponatinib_2 / 1015_CI-1040_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk 9_34371054_A_C
5 HIST1H2BK_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 6_132814681_A_G
6 SERPINE1_2 1498_Selumetinib_2 / 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 1_17240836_G_T / X_156025548_C_T
7 SGTB_1 1242_(5Z)-7-Oxozeaenol_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 other / erk_mapk / erk_mapk 9_74785802_T_C
8 XYLT2_1 1022_AZD7762_2 / 1378_Bleomycin(50uM)_1 g_integrity / DNArep 2_206056727_G_A
9 SOGA2_1 155_Ponatinib_2 / 1378_Bleomycin(50uM)_1 abl / DNArep 3_51980957_A_C
10 ZC3H12C_1 1378_Bleomycin(50uM)_1 / 1014_Refametinib_2 DNArep / erk_mapk 20_18452633_T_G
11 AFAP1L2_1 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk 2_39717176_T_G
12 CHRNA5_1 134_Etoposide_1 / 295_NVP-BHG712_3 DNArep / rtk 3_196708735_G_GA
13 ASGR2_1 1024_Lestauritinib_2 / 1014_Refametinib_2 rtk / erk_mapk 10_38696926_C_T
14 RHBDL2_5 1114_Cetuximab_1 egfr 15_40896089_A_G / 15_40900360_T_C / 5_150068208_G_A / 10_132859105_C_T / 10_132860307_C_T
15 TMEM206_3 252_WZ3105_3 other 2_108378352_C_G / 14_106335417_A_C / 14_106360128_A_C
16 SUPT4H1_1 1022_AZD7762_2 g_integrity 11_114444466_A_G
17 LRTOMT_1 1022_AZD7762_2 g_integrity 19_10162649_G_A
18 EME2_1 1378_Bleomycin(50uM)_1 DNArep 7_108180467_G_T
19 TMEM158_1 1241_CHIR-99021_3 wnt 17_60211179_G_A
20 EFS_1 1242_(5Z)-7-Oxozeaenol_3 other 19_30444797_C_A
21 CA5B_1 1378_Bleomycin(50uM)_1 DNArep 9_133696445_G_T
22 SDC1_1 1032_Afatinib_1 egfr 14_70246869_T_G
23 QSER1_1 226_GSK1070916_2 mitosis 13_79521022_A_T
24 GALNTL5_2 1012_Vorinostat_1 chromatin 15_34255437_A_T / 10_100352318_A_G
25 JAG1_5 1378_Bleomycin(50uM)_1 DNArep 3_122558313_G_T / 3_122558325_G_A / 3_122552357_T_TA / 3_122461164_C_G / 8_138636921_T_C
26 SOAT1_1 1022_AZD7762_2 g_integrity 7_108180467_G_T
27 BIRC2_1 231_FMK_3 erk_mapk 11_8101385_C_A
28 NAALADL2_1 1019_Bosutinib_1 abl 1_78893077_T_G
29 RGS2_1 1372_Trametinib_1 erk_mapk 18_12978734_C_G
30 PRR12_1 326_GSK690693_3 pi3k 6_38813973_C_T
31 AXL_2 1006_Cytarabine_1 DNArep 17_60211184_A_G / 5_224282_A_G
32 C6orf203_3 193_GW-2580_3 rtk 2_135390832_A_T / 17_48076840_A_G / 2_135230616_G_A
33 RNF208_2 255_CP724714_2 egfr 19_11832898_G_A / 4_7815971_GT_G
34 TNFRSF21_1 155_Ponatinib_2 abl 20_8802237_G_A
35 MAP6_1 29_AZ628_3 erk_mapk 7_6149477_GA_G
36 ABLIM1_1 1020_Lenalidomide_1 / 1017_Olaparib_2 / 1016_Temsirolimus_1 / 1170_CCT-018159_3 / 1004_Vinblastine_1 / 1033_Vismodegib_2 other / g_integrity / tor / other / cytoskeleton / other 4_70158293_T_TACAA
37 DIAPH1_5 1069_EHT-1864_3 / 222_BX-912_3 cytoskeleton / pi3k 7_73180651_C_T / 7_75212025_G_A / 7_74734035_C_T / 13_31758155_C_G / 7_72961358_G_A
38 FBXO10_5 222_BX-912_3 / 1008_Methotrexate_1 pi3k / DNArep 7_73180651_C_T / 7_75212025_G_A / 17_63918839_T_A / 7_72961358_G_A / 7_75403732_C_T
39 OLR1_1 1218_JQ1_3 chromatin 22_39017940_A_C
40 ADK_1 1001_AICA_Ribonucleotide_2 metabol 3_57269656_A_G
41 ETS1_5 1054_Palbociclib_2 cell_cyc 5_139680901_G_A / 5_150375777_G_T / 5_150393369_C_T / 9_41040359_C_T / 9_41938485_A_G
42 MDM2_4 1047_Nutlin-3a (-)_2 p53 8_89769704_A_C / 8_89786745_A_T / 8_89786749_T_TC / 8_89790263_A_G
43 NECAP1_1 1264_SGC0946_3 chromatin 11_92883335_A_C
44 PDZD8_1 194_Luminespib_2 other 2_120289468_AT_A
45 IFT46_1 1149_TW_37_3 apop 16_88608786_A_G
46 PLEKHA1_1 1032_Afatinib_1 egfr 16_89546571_ACC_AC
47 PTPN12_1 1006_Cytarabine_1 DNArep 7_63297679_T_C
48 CRH_1 277_Linifanib_2 rtk 2_208165676_C_T
49 UBE3B_1 301_PHA-793887_3 cell_cyc 1_3729650_T_C
여성암(breast, ovary) 약물에 대한 바이오 마커의 반응성 검증 결과
No. FRH Var_Exp(pval) Var_Drug(pval) Exp_Drug(pval) Ave_VarDrug(pval) Rank
1 IRX5_3 3.24E-08 2.09E-07 / 3.36E-07 / 1.23E-06 / 3.42E-06 / 5.09E-06 / 1.67E-05 / 7.91E-05 / 9.90E-05 / 0.000147359 / 0.000178145 / 0.000262223 / 0.000293231 / 0.000294131 / 0.000331406 / 0.000346165 / 0.000948858 / 0.002531744 / 0.002544254 / 0.002864291 / 0.003760149 / 0.004676935 / 0.004858024 / 0.005464656 / 0.005509754 / 0.005666416 / 0.005771071 / 0.006260361 / 0.006581211 / 0.006918188 / 0.007120129 / 0.00796253 / 0.008656866 / 0.009456152 / 0.009577377 / 0.009788614 4.01E-09 / 2.44E-07 / 2.68E-10 / 4.32E-09 / 3.38E-07 / 2.17E-07 / 0.00038571 / 0.000925853 / 7.73E-07 / 0.000383325 / 0.166450357 / 4.98E-06 / 3.01E-07 / 0.002000118 / 0.000442004 / 5.99E-05 / 0.000267605 / 0.213034545 / 0.159498838 / 0.00525218 / 0.00102741 / 0.020521632 / 0.009232963 / 0.002752168 / 0.238349359 / 0.011791795 / 0.003679783 / 0.012982528 / 0.023648082 / 0.203584523 / 4.71E-06 / 0.03105291 / 0.009132949 / 0.044459166 / 0.000738179 3.40E-03 35
2 IRX5_1 0.0000015986 0.0007150123535033939 / 0.0003369412837112573 / 0.00032406884840248645 / 0.03648245720851939 / 0.0011099296303187667 / 0.006369243766371333 / 0.0005814803877258011 / 2.2678944506803809e-07 / 0.03733962059148955 4.012472503651177e-09 / 2.6827328582081137e-10 / 4.315496540370196e-09 / 3.0113839929611485e-07 / 2.1676383298007365e-07 / 7.7324514359278e-07 / 3.3835336443110047e-07 / 2.4825768930569727e-07 / 4.858619088818164e-06 0.009251 9
3 CMIP_1 0.0000003363 0.00011611305549562358 / 0.0012463700637828415 / 0.0030883823789405102 / 0.0016967292437561562 / 0.009832494532448445 / 0.002480457099824004 1.6131899966597346e-09 / 6.919962939545994e-07 / 2.849790178430554e-07 / 2.9927531009991034e-06 / 1.2590036500767103e-06 / 2.2920451294642218e-05 0.003077 6
4 PREX1_1 0.0000031534 0.01213588709116456 / 0.0008861989870959789 / 0.003387644664627276 / 0.005046821727923961 / 0.003659189631662927 / 0.0025267752687901323 2.0425679890502906e-07 / 7.604358543728916e-08 / 1.5529027829933754e-06 / 8.474366468515741e-07 / 4.250842448563364e-06 / 0.00011933684147066083 0.004607 6
5 HIST1H2BK_1 0.0000012706 2.0249380516365964e-05 / 0.00145858467735631 / 0.00010968434987171273 1.2231056098636564e-07 / 5.613023240161599e-07 / 1.606715671371094e-06 0.00053 3
6 SERPINE1_2 0.0000002953 0.0003204627533032064 / 0.00024487596208109635 / 0.0018306053201144902 2.270680653678334e-11 / 2.0037545467736346e-09 / 1.775004443361545e-08 0.000799 3
7 SGTB_1 0.0000081282 0.03228197565235906 / 0.005309250379800075 / 0.014353588850730884 7.002520053010446e-07 / 5.734586888069177e-07 / 3.864698922480986e-05 0.017315 3
8 XYLT2_1 0.0000020721 0.001833777815813712 / 0.0011629202987970622 0.000260290223137108 / 2.671958043521113e-05 0.001498 2
9 SOGA2_1 0.0000002061 0.0023870087560347447 / 0.0009469777545024177 4.478657034092263e-06 / 1.4354947060633677e-06 0.001667 2
10 ZC3H12C_1 0.0000026717 0.00215309882934333 / 0.017221760779553733 4.767376309274578e-08 / 6.661607188017109e-09 0.009687 2
11 AFAP1L2_1 0.0000003807 0.004214389226040113 / 0.02332396009307528 5.907987029847344e-06 / 2.4672683509692957e-05 0.013769 2
12 CHRNA5_1 0.0000508839 0.006701963959523267 / 0.036047880162305805 1.9077675767419626e-05 / 0.0006068009313248781 0.021375 2
13 ASGR2_1 0.0000011382 0.02920277002386234 / 0.016061730805368494 3.539163247328943e-06 / 6.152399665513134e-06 0.022632 2
14 RHBDL2_5 0.0000019238 7.1199917547458675e-06 0.0003696677024808176 7.12E-06 1
15 TMEM206_3 0.0000000202 0.00010519155045059184 5.5593739090589024e-05 0.000105 1
16 SUPT4H1_1 0.0000006972 0.00033848343004505154 6.5359378871259295e-06 0.000338 1
17 LRTOMT_1 0.0000018098 0.000559295705994161 1.3683390744827602e-05 0.000559 1
18 EME2_1 0.0000170380 0.0006898652477534458 2.7131355664636215e-07 0.00069 1
19 TMEM158_1 0.0000030678 0.0009840625910486822 1.609343995544786e-08 0.000984 1
20 EFS_1 0.0002217830 0.001122491007265465 1.5915921114557537e-06 0.001122 1
21 CA5B_1 0.0000190483 0.0014397265221401374 8.834878342812196e-06 0.00144 1
22 SDC1_1 0.0000871778 0.0021240823853264194 0.000582674749763457 0.002124 1
23 QSER1_1 0.0036525535 0.0037407673565606763 0.006866210754238516 0.003741 1
24 GALNTL5_2 0.0000004536 0.0038242994255904676 3.729288833430345e-05 0.003824 1
25 JAG1_5 0.0001089795 0.00636641270645681 1.7383815237379935e-05 0.006366 1
26 SOAT1_1 0.0000020782 0.006999312347871926 2.80467015954591e-08 0.006999 1
27 BIRC2_1 0.0000155207 0.00816300663512002 0.00018077138183493182 0.008163 1
28 NAALADL2_1 0.0000138905 0.008284426750211397 4.480439955191913e-07 0.008284 1
29 RGS2_1 0.0000013280 0.009860060162808696 1.7551881489443127e-06 0.00986 1
30 PRR12_1 0.0000069754 0.009867491010242535 1.7189797251912035e-05 0.009867 1
31 AXL_2 0.0000000105 0.014240994766530759 1.5079800937023606e-08 0.014241 1
32 C6orf203_3 0.0000002251 0.01855978051000038 0.008786487798916599 0.01856 1
33 RNF208_2 0.0000001032 0.030124190690403667 0.009683329859510285 0.030124 1
34 TNFRSF21_1 0.0000749035 0.03240280858096773 0.00031416021519650137 0.032403 1
35 MAP6_1 0.0000692014 0.03353292578624218 0.00013432237477471032 0.033533 1
36 ABLIM1_1 0.0000289457 8.551014437375636e-05 / 6.439870760609185e-05 / 0.0004942044619000223 / 0.0013462707233938519 / 0.0001769380795123695 / 0.00046864428768627844 6.495937674540172e-07 / 8.724045720306562e-07 / 4.458187235187017e-06 / 0.00014338311206655668 / 8.320751548561286e-05 / 8.117521266562836e-06 0.000439 6
37 DIAPH1_5 0.0000000343 0.0021569775481875115 / 0.009558471051782936 4.2351723063700285e-07 / 0.0007897012263719693 0.005858 2
38 FBXO10_5 0.0000511525 0.012717520661373393 / 0.011413820480670385 3.075936790924862e-05 / 5.483582287867406e-06 0.012066 2
39 OLR1_1 0.0000390604 0.00013538297001416112 0.0010150743709979484 0.000135 1
40 ADK_1 0.0000356335 0.0003915086428142265 8.510841943631868e-06 0.000392 1
41 ETS1_5 0.0000663161 0.00041860694731410804 7.897108946289616e-05 0.000419 1
42 MDM2_4 0.0000777136 0.00045220053022167466 1.1021957487827008e-06 0.000452 1
43 NECAP1_1 0.0000018931 0.006023068066858825 1.373445231848715e-05 0.006023 1
44 PDZD8_1 0.0000027222 0.011837688751336296 0.0006499029052944853 0.011838 1
45 IFT46_1 0.0000115713 0.016014639151541662 0.004518015024378813 0.016015 1
46 PLEKHA1_1 0.0011885939 0.01781962701682115 1.7283045033609196e-07 0.01782 1
47 PTPN12_1 0.0001114367 0.02274194948059581 1.024090488420046e-06 0.022742 1
48 CRH_1 0.0000029508 0.03250849770203413 0.0017907240115171536 0.032508 1
49 UBE3B_1 0.0000100508 0.048482309371415636 1.9954445445928623e-06 0.048482 1
[표 6]에는 뇌종양(brain) 약물에 연관된 FRH 들과, 이와 연관된 뇌종양 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 7] 에는 [표 6]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(Pvlaue)값을 의미하는 것으로, [표 6]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 6]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 뇌종양 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 29에는 표 6에 기재된 바이오마커들 중 주요 바이오마커들의 뇌종양 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 30에는 주요 바이오마커들에 의해 발현된 유전자들과 뇌종양 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
뇌종양(brain) 약물에 대한 반응성 바이오 마커
No. FRH Drug DrugType Var(마커)
1 PTRF_9 9_MG-132 / 17_Cyclopamine / 34_Imatinib / 51_Dasatinib / 56_WH-4-023 / 94_TGX221 / 104_Bortezomib / 106_XMD8-85 / 147_NSC-87877 / 150_Bicalutamide / 151_QS11 / 156_AZD6482 / 159_HG-6-64-1 / 175_PAC-1 / 176_IPA-3 / 178_BAY 61-3606 / 179_5-Fluorouracil / 184_BMS-754807 / 185_OSI-906 / 186_Bexarotene / 196_Phenformin / 199_Pazopanib / 200_LAQ824 / 211_TL-2-105 / 221_TAK-715 / 226_GSK1070916 / 228_KIN001-102 / 253_XMD14-99 / 254_AC220 / 255_CP724714 / 257_NPK76-II-72-1 / 263_FR-180204 / 265_Tubastatin A / 269_NSC-207895 / 272_AR-42 / 275_I-BET-762 / 276_CAY10603 / 281_CH5424802 / 288_KIN001-055 / 290_KIN001-260 / 291_KIN001-266 / 293_MP470 / 294_MPS-1-IN-1 / 300_CX-5461 / 304_SB52334 / 305_TPCA-1 / 310_YM201636 / 333_T0901317 / 344_THZ-2-49 / 345_KIN001-270 / 1007_Docetaxel / 1008_Methotrexate / 1011_ABT-263 / 1012_Vorinostat / 1016_Temsirolimus / 1020_Lenalidomide / 1021_Axitinib / 1026_17-AAG / 1043_JNK Inhibitor VIII / 1091_BMS-536924 / 1166_QL-VIII-58 / 1248_FK866 / 1261_rTRAIL / 1262_UNC1215 / 1264_SGC0946 / 1526_RDEA119 (rescreen) / 1527_GDC0941 (rescreen) other / other / abl / abl / abl / pi3k / other / other / other / other / other / pi3k / erk_mapk / apop / cytoskeleton / other / DNArep / igfr / igfr / other / metabol / rtk / chromatin / erk_mapk / jnk_p38 / mitosis / pi3k / rtk / rtk / egfr / mitosis / erk_mapk / chromatin / p53 / chromatin / chromatin / chromatin / rtk / other / other / other / rtk / mitosis / other / rtk / other / other / other / cell_cyc / cell_cyc / cytoskeleton / DNArep / apop / chromatin / tor / other / rtk / other / jnk_p38 / igfr / tor / metabol / apop / other / chromatin / erk_mapk / pi3k 11_12162199_T_G / 13_113159942_A_G / 5_181155466_T_G / 11_65547388_T_G / 10_11921140_T_G / 17_55774876_T_G / 12_40313960_G_T / 16_1817242_T_C / 2_113934259_C_T
2 MBTD1_5 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 226_GSK1070916_2 / 179_5-Fluorouracil_1 / 221_TAK-715_2 / 257_NPK76-II-72-1_3 / 275_I-BET-762_3 / 276_CAY10603_3 / 1011_Navitoclax_2 / 269_NSC-207895_3 / 281_Alectinib_2 / 300_CX-5461_3 / 265_Tubastatin A_3 / 185_Linsitinib_2 / 253_XMD14-99_3 other / mitosis / rtk / chromatin / mitosis / DNArep / jnk_p38 / mitosis / chromatin / chromatin / apop / p53 / rtk / other / chromatin / igfr / rtk 17_55774876_T_G / 15_65451964_A_G / 2_113934259_C_T / 12_57062993_T_G / 11_65547388_T_G
3 C12orf29_4 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 275_I-BET-762_3 / 272_AR-42_2 / 310_YM201636_3 / 1012_Vorinostat_1 / 276_CAY10603_3 / 184_BMS-754807_2 mitosis / igfr / erk_mapk / other / chromatin / chromatin / other / chromatin / chromatin / igfr 12_40313960_G_T / 4_173528913_A_G / 15_65451964_A_G / 10_79312556_A_G
4 DDX20_1 294_MPS-1-IN-1_3 / 265_Tubastatin A_3 / 305_TPCA-1_3 / 300_CX-5461_3 / 257_NPK76-II-72-1_3 / 179_5-Fluorouracil_1 / 290_KIN001-260_3 / 276_CAY10603_3 / 1012_Vorinostat_1 / 345_KIN001-270_3 mitosis / chromatin / other / other / mitosis / DNArep / other / chromatin / chromatin / cell_cyc 8_30756677_T_G
5 TACC1_4 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 221_TAK-715_2 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 253_XMD14-99_3 / 300_CX-5461_3 chromatin / mitosis / rtk / jnk_p38 / DNArep / other / rtk / erk_mapk / rtk / other 11_12162199_T_G / 12_51745916_T_G / 16_15664675_G_T / 16_55415_T_G
6 SFPQ_1 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 179_5-Fluorouracil_1 / 309_Y-39983_3 / 265_Tubastatin A_3 / 275_I-BET-762_3 / 263_FR-180204_3 chromatin / other / mitosis / other / other / DNArep / cytoskeleton / chromatin / chromatin / erk_mapk 8_30756677_T_G
7 LRPPRC_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 1091_BMS-536924_3 / 253_XMD14-99_3 / 293_Amuvatinib_2 / 184_BMS-754807_2 / 257_NPK76-II-72-1_3 mitosis / other / rtk / igfr / chromatin / igfr / rtk / rtk / igfr / mitosis 12_40313960_G_T / 11_12162199_T_G
8 ILF3_5 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 1011_Navitoclax_2 / 263_FR-180204_3 / 288_WHI-P97_3 / 257_NPK76-II-72-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / other / chromatin / apop / erk_mapk / other / mitosis / DNArep / rtk 5_181155466_T_G / 2_113934259_C_T / 11_12162199_T_G / 12_6818898_A_C / 15_65451964_A_G
9 ATXN7L3B_5 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 / 185_Linsitinib_2 / 226_GSK1070916_2 / 184_BMS-754807_2 other / mitosis / chromatin / rtk / mitosis / p53 / igfr / mitosis / igfr 2_113934259_C_T / 5_181155466_T_G / 15_65451964_A_G / 2_108507561_T_G / 12_57062993_T_G
10 CENPV_1 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 300_CX-5461_3 / 305_TPCA-1_3 / 304_SB52334_3 / 1011_Navitoclax_2 / 185_Linsitinib_2 DNArep / chromatin / rtk / mitosis / other / other / rtk / apop / igfr 5_181155466_T_G
11 CAMKV_4 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 253_XMD14-99_3 mitosis / DNArep / other / other / rtk / chromatin / erk_mapk / rtk 13_113159942_A_G / 16_1817242_T_C / 3_128945112_G_A / 20_42084724_T_C
12 TPMT_3 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 226_GSK1070916_2 rtk / mitosis / chromatin / rtk / DNArep / igfr / igfr / mitosis 9_37887606_C_T / 2_61492168_C_A / 11_12162199_T_G
13 WASF1_3 305_TPCA-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 / 269_NSC-207895_3 / 185_Linsitinib_2 other / chromatin / DNArep / mitosis / rtk / other / p53 / igfr 16_55415_T_G / 10_43200831_A_G / 2_108507561_T_G
14 DDX25_4 263_FR-180204_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 255_CP724714_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 erk_mapk / chromatin / mitosis / other / rtk / egfr / other / DNArep 2_61492168_C_A / 5_181155466_T_G / 11_43920052_A_C / 12_40313960_G_T
15 ACVR2B_5 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 265_Tubastatin A_3 / 1011_Navitoclax_2 / 263_FR-180204_3 DNArep / mitosis / rtk / chromatin / other / chromatin / apop / erk_mapk 16_1817242_T_C / 10_11921140_T_G / 13_113159942_A_G / 20_42084724_T_C / 11_34452090_T_G
16 TAP1_4 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 1011_Navitoclax_2 / 304_SB52334_3 / 305_TPCA-1_3 / 275_I-BET-762_3 mitosis / DNArep / chromatin / igfr / apop / rtk / other / chromatin 11_12162199_T_G / 10_11921140_T_G / 5_181155466_T_G / 20_42084724_T_C
17 SMPD1_1 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 1011_Navitoclax_2 / 265_Tubastatin A_3 chromatin / DNArep / other / other / mitosis / jnk_p38 / apop / chromatin 16_87644643_G_A
18 PEA15_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 293_Amuvatinib_2 / 226_GSK1070916_2 / 305_TPCA-1_3 / 221_TAK-715_2 / 263_FR-180204_3 chromatin / mitosis / rtk / rtk / mitosis / other / jnk_p38 / erk_mapk 5_181155466_T_G / 10_50311228_T_G / 11_12162199_T_G / 22_18345007_A_C / 2_60761746_T_G
19 SLC25A43_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 253_XMD14-99_3 / 179_5-Fluorouracil_1 mitosis / other / rtk / igfr / chromatin / erk_mapk / rtk / DNArep 1_54243266_A_G
20 MT2A_5 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 275_I-BET-762_3 / 304_SB52334_3 / 185_Linsitinib_2 mitosis / DNArep / other / mitosis / chromatin / rtk / igfr 13_113159942_A_G / 22_42212334_A_C / 10_11921140_T_G / 15_75524142_T_C / X_100585180_G_T
21 RUNX1_2 196_Phenformin_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 94_TGX221_3 / 1166_QL-VIII-58_3 / 51_Dasatinib_1 / 1007_Docetaxel_1 metabol / cell_cyc / pi3k / pi3k / tor / abl / cytoskeleton 1_78629896_T_C / 8_7290003_A_C
22 LRRC8B_3 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 263_FR-180204_3 / 276_CAY10603_3 mitosis / rtk / other / DNArep / other / erk_mapk / chromatin 12_40313960_G_T / 11_12162199_T_G / 17_55774876_T_G
23 PSMB9_4 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 275_I-BET-762_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 mitosis / rtk / DNArep / chromatin / other / chromatin / igfr 11_12162199_T_G / 10_11921140_T_G / 16_55415_T_G / X_2856636_A_C
24 RRAS_5 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 269_NSC-207895_3 / 304_SB52334_3 mitosis / DNArep / other / apop / other / p53 / rtk 11_12162199_T_G / 2_113934259_C_T / 16_18379704_T_G / 13_113159942_A_G / 17_55774876_T_G
25 TMBIM1_5 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 185_Linsitinib_2 mitosis / DNArep / rtk / other / chromatin / other / igfr 17_51169925_C_T / 1_228244520_T_G / 1_213007133_T_G / 16_55415_T_G / 5_38950065_A_T
26 KLHL23_3 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 263_FR-180204_3 / 1011_Navitoclax_2 / 300_CX-5461_3 / 1012_Vorinostat_1 mitosis / DNArep / rtk / erk_mapk / apop / other / chromatin 13_113159942_A_G / 10_79312556_A_G / 13_113325635_A_G
27 EWSR1_1 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 288_WHI-P97_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 310_YM201636_3 mitosis / apop / other / other / DNArep / chromatin / other 20_42084724_T_C
28 ZNF124_3 1012_Vorinostat_1 / 1011_Navitoclax_2 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 chromatin / apop / rtk / mitosis / other / other / DNArep 13_113159942_A_G / 2_170965958_A_C / 17_55774876_T_G
29 CAPG_2 1026_Tanespimycin_2 / 344_THZ-2-49_3 / 196_Phenformin_3 / 1527_Pictilisib_2 / 17_Cyclopamine_3 / 94_TGX221_3 / 1007_Docetaxel_1 other / cell_cyc / metabol / pi3k / other / pi3k / cytoskeleton 7_72942379_A_C / 15_56464990_A_C
30 TGOLN2_2 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 304_SB52334_3 / 300_CX-5461_3 chromatin / DNArep / mitosis / other / erk_mapk / rtk / other 19_7740447_T_G / 19_11402175_A_C
31 RBFOX1_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2 / 305_TPCA-1_3 / 253_XMD14-99_3 mitosis / rtk / other / DNArep / rtk / other / rtk 1_213007133_T_G
32 RANBP2_2 305_TPCA-1_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 269_NSC-207895_3 / 257_NPK76-II-72-1_3 other / rtk / mitosis / DNArep / other / p53 / mitosis 11_65547388_T_G / 15_55329691_T_C
33 CCT2_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 269_NSC-207895_3 / 272_AR-42_2 / 185_Linsitinib_2 mitosis / other / chromatin / erk_mapk / p53 / chromatin / igfr 12_40313960_G_T
34 CEP95_2 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 304_SB52334_3 / 253_XMD14-99_3 / 281_Alectinib_2 / 1012_Vorinostat_1 DNArep / mitosis / mitosis / rtk / rtk / rtk / chromatin 17_55774876_T_G / 11_12162199_T_G
35 GINM1_3 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 184_BMS-754807_2 / 1091_BMS-536924_3 mitosis / erk_mapk / rtk / igfr / chromatin / igfr / igfr 11_12162199_T_G / 4_154328181_A_C / 10_73803641_A_G
36 POLG2_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 304_SB52334_3 / 1091_BMS-536924_3 / 281_Alectinib_2 / 253_XMD14-99_3 chromatin / mitosis / jnk_p38 / rtk / igfr / rtk / rtk 22_22098988_G_T / 19_4911043_A_C
37 RAN_2 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2 mitosis / apop / chromatin / erk_mapk / other / DNArep / rtk 19_3281403_A_C / 10_11921140_T_G
38 MTF2_2 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 265_Tubastatin A_3 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 / 304_SB52334_3 other / mitosis / DNArep / chromatin / mitosis / p53 / rtk 5_181155466_T_G / 6_30705792_T_G
39 CMPK1_1 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 184_BMS-754807_2 / 1012_Vorinostat_1 / 293_Amuvatinib_2 / 253_XMD14-99_3 / 304_SB52334_3 igfr / mitosis / igfr / chromatin / rtk / rtk / rtk 16_18379704_T_G
40 MDN1_1 1012_Vorinostat_1 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 276_CAY10603_3 / 305_TPCA-1_3 / 269_NSC-207895_3 chromatin / apop / DNArep / mitosis / chromatin / other / p53 11_65547388_T_G
41 INPP1_2 265_Tubastatin A_3 / 276_CAY10603_3 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 310_YM201636_3 chromatin / chromatin / other / mitosis / DNArep / other 14_78966462_C_T / 16_55415_T_G
42 TOMM20_5 1012_Vorinostat_1 / 253_XMD14-99_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 chromatin / rtk / DNArep / mitosis / rtk / other 10_11921140_T_G / 20_42084724_T_C / 2_61492168_C_A / 17_55774876_T_G / 16_18379704_T_G
43 S100A6_3 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 305_TPCA-1_3 chromatin / mitosis / rtk / DNArep / apop / other 10_11921140_T_G / 7_159142364_T_G / 8_30756677_T_G
44 ZNF74_5 1012_Vorinostat_1 / 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 305_TPCA-1_3 / 304_SB52334_3 chromatin / igfr / mitosis / igfr / other / rtk 5_181155466_T_G / 17_55774876_T_G / 1_234373536_T_G / 2_113934259_C_T / 2_61492168_C_A
45 ZNF195_3 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 185_Linsitinib_2 / 226_GSK1070916_2 mitosis / other / rtk / erk_mapk / igfr / mitosis 12_40313960_G_T / 2_113934259_C_T / 12_51745916_T_G
46 DNMT3A_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 263_FR-180204_3 / 1091_BMS-536924_3 mitosis / other / chromatin / igfr / erk_mapk / igfr 2_113934259_C_T / 11_12162199_T_G
47 PXDC1_3 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 mitosis / rtk / other / igfr / DNArep / chromatin 13_113159942_A_G / 11_65547388_T_G / 7_159142364_T_G
48 HOXD8_1 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 185_Linsitinib_2 / 281_Alectinib_2 rtk / mitosis / rtk / erk_mapk / igfr / rtk 20_42084724_T_C
49 CREB3_5 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 253_XMD14-99_3 / 304_SB52334_3 mitosis / chromatin / other / DNArep / rtk / rtk 5_181155466_T_G / 1_54243266_A_G / 11_12162199_T_G / 6_30705792_T_G / 12_6818898_A_C
50 HDAC2_5 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 293_Amuvatinib_2 / 1012_Vorinostat_1 / 304_SB52334_3 apop / DNArep / other / rtk / chromatin / rtk 17_55774876_T_G / 11_65547388_T_G / 15_75524142_T_C / 14_55169342_TAAA_T / 15_55329691_T_C
51 TIMP1_5 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 253_XMD14-99_3 DNArep / other / other / mitosis / apop / rtk 16_1817242_T_C / 3_128945112_G_A / 5_181155466_T_G / 16_30398066_C_A / 11_34452090_T_G
52 COQ10B_2 305_TPCA-1_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 other / chromatin / mitosis / rtk / igfr / DNArep 13_113159942_A_G / 1_149852603_A_G
53 REEP5_3 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 257_NPK76-II-72-1_3 / 304_SB52334_3 mitosis / other / DNArep / other / mitosis / rtk 5_181155466_T_G / 16_87644643_G_A / 2_113934259_C_T
54 FAM111A_5 304_SB52334_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 1091_BMS-536924_3 rtk / mitosis / igfr / chromatin / other / igfr 2_108507561_T_G / 13_113159942_A_G / 10_11921140_T_G / 16_1817242_T_C / 1_213007133_T_G
55 XPO5_2 1012_Vorinostat_1 / 269_NSC-207895_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 276_CAY10603_3 / 294_MPS-1-IN-1_3 chromatin / p53 / other / mitosis / chromatin / mitosis 15_75524142_T_C / 11_65547388_T_G
56 MICALL2_2 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 / 156_AZD6482_2 cell_cyc / metabol / pi3k / other / abl / pi3k 8_7290003_A_C / 7_72942379_A_C
57 ITGA3_1 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 288_WHI-P97_3 mitosis / chromatin / erk_mapk / other / DNArep / other 5_181155466_T_G
58 MATR3_5 304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 269_NSC-207895_3 / 1011_Navitoclax_2 rtk / other / mitosis / DNArep / p53 / apop 17_55774876_T_G / 10_73803531_T_C / 11_65547388_T_G / 12_7433515_G_T / 16_18379704_T_G
59 SAT1_1 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 185_Linsitinib_2 mitosis / rtk / chromatin / erk_mapk / other / igfr 12_40313960_G_T
60 TMED9_2 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 other / mitosis / rtk / igfr / chromatin / erk_mapk 13_113159942_A_G / 11_12162199_T_G
61 KIF26A_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 1091_BMS-536924_3 / 263_FR-180204_3 / 185_Linsitinib_2 chromatin / mitosis / rtk / igfr / erk_mapk / igfr 10_11921140_T_G / 7_159142364_T_G
62 C19orf66_2 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 253_XMD14-99_3 / 293_Amuvatinib_2 / 310_YM201636_3 mitosis / rtk / other / rtk / rtk / other 16_87644643_G_A / X_2856636_A_C
63 GTF3C2_2 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 263_FR-180204_3 / 281_Alectinib_2 / 185_Linsitinib_2 mitosis / chromatin / rtk / erk_mapk / rtk / igfr 7_128839939_T_G / 7_159142364_T_G
64 ADAM9_5 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 185_Linsitinib_2 / 1011_Navitoclax_2 mitosis / rtk / DNArep / rtk / igfr / apop 11_12162199_T_G / 12_51745916_T_G / 10_11921140_T_G / 8_122952205_T_G / 5_181155466_T_G
65 KDM1A_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 176_IPA-3_3 / 179_5-Fluorouracil_1 / 276_CAY10603_3 mitosis / chromatin / other / cytoskeleton / DNArep / chromatin 1_26774532_T_C / 22_42212334_A_C / 5_181155466_T_G
66 SRSF1_1 1012_Vorinostat_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 179_5-Fluorouracil_1 / 281_Alectinib_2 chromatin / rtk / mitosis / mitosis / DNArep / rtk 16_87644643_G_A
67 WHAMM_1 1012_Vorinostat_1 / 305_TPCA-1_3 / 281_Alectinib_2 / 263_FR-180204_3 / 300_CX-5461_3 / 253_XMD14-99_3 chromatin / other / rtk / erk_mapk / other / rtk 2_113934259_C_T
68 LEPRE1_4 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 106_XMD8-85_3 / 156_AZD6482_2 cell_cyc / pi3k / other / metabol / other / pi3k 3_191357867_G_A / 16_72119226_C_G / 3_191358113_C_T / 16_72150667_C_T
69 TRMT61B_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 265_Tubastatin A_3 / 276_CAY10603_3 / 185_Linsitinib_2 mitosis / other / rtk / chromatin / chromatin / igfr 12_124473081_C_T
70 KANK1_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 305_TPCA-1_3 / 253_XMD14-99_3 mitosis / rtk / igfr / igfr / other / rtk 11_12162199_T_G
71 FAM126A_1 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 156_AZD6482_2 / 51_Dasatinib_1 / 196_Phenformin_3 pi3k / cell_cyc / other / pi3k / abl / metabol 7_72942379_A_C
72 CASKIN1_1 1012_Vorinostat_1 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 chromatin / apop / DNArep / mitosis / rtk / igfr 10_11921140_T_G
73 PHIP_3 269_NSC-207895_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 257_NPK76-II-72-1_3 / 300_CX-5461_3 p53 / mitosis / other / DNArep / mitosis / other 15_55329691_T_C / 15_55340661_G_T / 12_40313960_G_T
74 ISL1_1 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 1011_Navitoclax_2 / 281_Alectinib_2 / 304_SB52334_3 mitosis / chromatin / erk_mapk / apop / rtk / rtk 11_12162199_T_G
75 FAM114A1_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 275_I-BET-762_3 / 300_CX-5461_3 mitosis / DNArep / chromatin / other / chromatin / other 12_51745916_T_G
76 BHLHE40_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 1091_BMS-536924_3 chromatin / mitosis / erk_mapk / rtk / other / igfr 11_12162199_T_G / 6_30705792_T_G / 8_122952205_T_G / 14_93183653_A_C / 12_6941768_C_A
77 RNH1_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 269_NSC-207895_3 / 281_Alectinib_2 / 253_XMD14-99_3 mitosis / DNArep / other / p53 / rtk / rtk 16_1817242_T_C / 13_113159942_A_G
78 SLC35F5_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 1012_Vorinostat_1 / 300_CX-5461_3 mitosis / other / DNArep / rtk / chromatin / other 17_6118065_A_G / 13_113159942_A_G
79 TRAP1_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 263_FR-180204_3 / 1011_Navitoclax_2 chromatin / mitosis / other / rtk / erk_mapk / apop 9_69516199_A_C
80 SLC10A3_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 304_SB52334_3 DNArep / mitosis / chromatin / other / other / rtk 13_113159942_A_G
81 IL10RB_1 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 184_BMS-754807_2 / 263_FR-180204_3 igfr / mitosis / apop / other / igfr / erk_mapk 11_65547388_T_G
82 CCDC138_3 269_NSC-207895_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 257_NPK76-II-72-1_3 p53 / chromatin / other / DNArep / mitosis 15_75524142_T_C / 12_40313960_G_T / 8_30756677_T_G
83 LDLRAP1_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 304_SB52334_3 / 179_5-Fluorouracil_1 mitosis / other / igfr / rtk / DNArep 16_55415_T_G
84 SH3BGRL3_3 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 304_SB52334_3 / 253_XMD14-99_3 DNArep / other / apop / rtk / rtk 17_55774876_T_G / 16_87644643_G_A / 5_181155466_T_G
85 RARRES3_3 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 179_5-Fluorouracil_1 / 263_FR-180204_3 / 1012_Vorinostat_1 mitosis / chromatin / DNArep / erk_mapk / chromatin 12_40313960_G_T / 1_213007133_T_G / 16_87644643_G_A
86 ANXA4_4 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 293_Amuvatinib_2 mitosis / chromatin / rtk / DNArep / rtk 19_11402175_A_C / 6_33799054_A_G / 8_30756677_T_G / 8_27431326_A_G
87 LYST_1 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 / 310_YM201636_3 chromatin / other / mitosis / rtk / other 16_55415_T_G
88 MR1_4 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 1012_Vorinostat_1 mitosis / apop / DNArep / other / chromatin 1_234373536_T_G / 15_84241166_A_C / 10_79312556_A_G / 19_7740447_T_G
89 SELRC1_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 226_GSK1070916_2 / 253_XMD14-99_3 mitosis / other / chromatin / mitosis / rtk 12_40313960_G_T
90 LDHB_5 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 chromatin / other / mitosis / DNArep / apop 12_40313960_G_T / 11_12162199_T_G / 11_65547388_T_G / 5_181155466_T_G / 4_108762737_T_G
91 GBE1_2 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 51_Dasatinib_1 cell_cyc / pi3k / other / metabol / abl 8_7290003_A_C / 7_72942379_A_C
92 PTRF_2 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 cell_cyc / pi3k / metabol / other / abl 8_7290003_A_C / 7_72942379_A_C
93 SQSTM1_3 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 304_SB52334_3 / 179_5-Fluorouracil_1 mitosis / other / igfr / rtk / DNArep 1_26774532_T_C / 11_12162199_T_G / 13_39724512_C_T
94 PA2G4_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1011_Navitoclax_2 / 310_YM201636_3 chromatin / mitosis / other / apop / other 12_40313960_G_T
95 GBP3_2 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 1091_BMS-536924_3 / 305_TPCA-1_3 / 253_XMD14-99_3 mitosis / chromatin / igfr / other / rtk 15_75524142_T_C / 12_40313960_G_T
96 CHD7_2 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 275_I-BET-762_3 DNArep / mitosis / chromatin / other / chromatin 11_65547388_T_G / 12_40313960_G_T
97 ELF4_4 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1091_BMS-536924_3 / 304_SB52334_3 / 263_FR-180204_3 mitosis / igfr / igfr / rtk / erk_mapk 13_113159942_A_G / 8_28850143_T_G / 2_108507561_T_G / 16_30953637_A_C
98 HEXB_2 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 1012_Vorinostat_1 mitosis / rtk / DNArep / other / chromatin 11_65547388_T_G / 11_12162199_T_G
99 TGOLN2_3 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 156_AZD6482_2 cell_cyc / metabol / pi3k / other / pi3k 2_105307612_A_C / 7_72942379_A_C / 8_7290003_A_C
100 CBR3_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 276_CAY10603_3 chromatin / mitosis / DNArep / other / chromatin 8_30756677_T_G / 3_128945112_G_A / 12_6818898_A_C / 22_22098988_G_T / 2_60761746_T_G
101 C14orf93_1 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 263_FR-180204_3 / 253_XMD14-99_3 chromatin / DNArep / igfr / erk_mapk / rtk 20_42084724_T_C
102 ACVR1B_5 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 281_Alectinib_2 apop / mitosis / igfr / chromatin / rtk 5_181155466_T_G / 11_12162199_T_G / 10_79312556_A_G / 2_113934259_C_T / 12_6818898_A_C
103 WNK2_1 1011_Navitoclax_2 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3 apop / chromatin / DNArep / rtk / mitosis 10_11921140_T_G
104 GBE1_5 1012_Vorinostat_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 chromatin / rtk / mitosis / DNArep / other 5_181155466_T_G / 16_58525116_G_T / 11_73355795_A_G / 10_11921140_T_G / 8_122952205_T_G
105 RAB27A_2 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 156_AZD6482_2 cell_cyc / metabol / pi3k / other / pi3k 8_7290003_A_C / 15_56464990_A_C
106 FAP_3 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 221_TAK-715_2 / 345_KIN001-270_3 mitosis / DNArep / chromatin / jnk_p38 / cell_cyc 17_55774876_T_G / 1_183963850_T_G / 11_94082585_T_C
107 THBS1_1 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 cell_cyc / metabol / pi3k / other / abl 8_7290003_A_C
108 RNF44_2 1012_Vorinostat_1 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 221_TAK-715_2 / 305_TPCA-1_3 chromatin / igfr / DNArep / jnk_p38 / other 8_12430448_C_T / 10_11921140_T_G
109 C2orf44_4 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 igfr / mitosis / chromatin / other / DNArep 7_108023984_G_A / 7_108024001_C_T / 11_65547388_T_G / 14_55169342_TAAA_T
110 ZSCAN2_1 304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 226_GSK1070916_2 rtk / other / mitosis / igfr / mitosis 2_61492168_C_A
111 PSMB8_3 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 275_I-BET-762_3 mitosis / rtk / DNArep / igfr / chromatin 11_12162199_T_G / X_2856636_A_C / 10_11921140_T_G
112 CTGF_2 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 mitosis / chromatin / rtk / igfr / DNArep 13_113159942_A_G / 2_188994726_T_G
113 DAP_1 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 igfr / mitosis / chromatin / igfr / DNArep 12_51745916_T_G
114 PHOX2A_1 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 1091_BMS-536924_3 mitosis / chromatin / DNArep / igfr / igfr 12_51745916_T_G
115 MVP_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 253_XMD14-99_3 mitosis / DNArep / chromatin / other / rtk 12_40313960_G_T / 11_68785018_G_A
116 CCNJ_2 304_SB52334_3 / 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 / 305_TPCA-1_3 / 263_FR-180204_3 rtk / mitosis / rtk / other / erk_mapk 14_55169342_TAAA_T / 1_234373536_T_G
117 MAP4_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 221_TAK-715_2 mitosis / rtk / other / chromatin / jnk_p38 16_81270082_T_G / 14_93183653_A_C / 1_54243266_A_G / 2_157299566_T_G / 16_58526137_A_C
118 ATP5B_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 305_TPCA-1_3 / 263_FR-180204_3 chromatin / mitosis / igfr / other / erk_mapk 1_54243266_A_G / 6_31966660_T_G
119 TRAM2_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 263_FR-180204_3 / 1091_BMS-536924_3 mitosis / chromatin / rtk / erk_mapk / igfr 11_12162199_T_G / 13_113159942_A_G / 12_40313960_G_T
120 CCDC107_5 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 263_FR-180204_3 chromatin / other / mitosis / other / erk_mapk 17_19414393_T_G / 11_1242476_T_G / 16_259458_T_G / 1_54243266_A_G / 1_171541102_T_G
121 SMARCAD1_5 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 mitosis / other / rtk / igfr / igfr 12_40313960_G_T / 15_65451964_A_G / 11_65547388_T_G / 6_30705792_T_G / 17_55774876_T_G
122 HRH1_1 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 263_FR-180204_3 mitosis / igfr / chromatin / DNArep / erk_mapk 9_108900415_C_A
123 KHDRBS1_2 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 257_NPK76-II-72-1_3 chromatin / other / mitosis / igfr / mitosis 5_181155466_T_G / 12_6818898_A_C
124 E2F6_3 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 184_BMS-754807_2 / 305_TPCA-1_3 igfr / mitosis / erk_mapk / igfr / other 1_248122139_G_T / 1_248122185_A_G / 12_109800676_G_A
125 ELL2_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 1091_BMS-536924_3 / 305_TPCA-1_3 chromatin / mitosis / erk_mapk / igfr / other 10_73803531_T_C / 5_181155466_T_G
126 BSN_2 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2 mitosis / igfr / other / DNArep / rtk 16_1817242_T_C / 13_113159942_A_G
127 ATG4A_5 1012_Vorinostat_1 / 305_TPCA-1_3 / 253_XMD14-99_3 / 226_GSK1070916_2 chromatin / other / rtk / mitosis 2_61492168_C_A / 2_113934259_C_T / 9_108900415_C_A / 16_87644643_G_A / 9_35398502_T_G
128 CD44_4 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 chromatin / other / mitosis / igfr 12_40313960_G_T / 15_75524142_T_C / 12_51745916_T_G / 2_113934259_C_T
129 GSN_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 chromatin / mitosis / apop / DNArep 10_11921140_T_G / 13_113159942_A_G / 5_181155466_T_G / 16_1817242_T_C / 15_75524142_T_C
130 CD99_5 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / apop / DNArep / rtk 16_1817242_T_C / 11_65547388_T_G / 11_12162199_T_G / 5_181155466_T_G / 10_11921140_T_G
131 GNAI2_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 1011_Navitoclax_2 mitosis / rtk / chromatin / apop 1_149852603_A_G / 1_150261398_T_G / 17_55774876_T_G / 1_154627925_A_C / 17_77213881_T_G
132 DDX60_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 mitosis / rtk / DNArep / other 11_12162199_T_G / 16_87644643_G_A / 2_108507561_T_G / 5_181155466_T_G / 1_26774532_T_C
133 MICALL2_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 263_FR-180204_3 mitosis / chromatin / DNArep / erk_mapk 16_30953637_A_C / 11_12162199_T_G / 12_51745916_T_G
134 SOAT1_5 185_Linsitinib_2 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 igfr / rtk / mitosis / other 5_181155466_T_G / 5_38950065_A_T / 12_40313960_G_T / 17_51169925_C_T / 2_61492168_C_A
135 PLEC_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 / 94_TGX221_3 cell_cyc / other / abl / pi3k 7_72942379_A_C
136 XRCC5_1 253_XMD14-99_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 rtk / erk_mapk / mitosis / DNArep 20_42084724_T_C
137 OSGEPL1_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 253_XMD14-99_3 erk_mapk / mitosis / chromatin / rtk 12_40313960_G_T
138 TMEM97_4 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 1012_Vorinostat_1 / 300_CX-5461_3 DNArep / apop / chromatin / other 17_55774876_T_G / 20_33848655_A_C / 1_150261398_T_G / 12_6818898_A_C
139 GLIS3_4 185_Linsitinib_2 / 1091_BMS-536924_3 / 184_BMS-754807_2 / 1012_Vorinostat_1 igfr / igfr / igfr / chromatin 11_65547388_T_G / 2_66439901_A_C / 10_50311228_T_G / 8_41957277_G_C
140 ANXA1_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 mitosis / rtk / chromatin / igfr 12_51745916_T_G / 5_181155466_T_G / 10_11921140_T_G / 13_113159942_A_G / 16_1817242_T_C
141 FAM120A_5 179_5-Fluorouracil_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 DNArep / rtk / mitosis / other 13_113159942_A_G / 3_128945112_G_A / 12_123499406_T_G / 20_42084724_T_C / 6_30705792_T_G
142 SAFB_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 305_TPCA-1_3 mitosis / chromatin / rtk / other 13_113159942_A_G / 14_55169342_TAAA_T / 10_11921140_T_G
143 ACTN4_4 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 mitosis / rtk / igfr / DNArep 11_12162199_T_G / 12_51745916_T_G / 10_73803641_A_G / 1_213007133_T_G
144 FAM117B_5 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 DNArep / mitosis / chromatin / other 5_181155466_T_G / 13_113159942_A_G / 1_15381304_A_C / 17_55774876_T_G / 10_11921140_T_G
145 TSSC1_1 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 263_FR-180204_3 igfr / mitosis / igfr / erk_mapk 2_113934259_C_T
146 SERPINE2_1 94_TGX221_3 / 56_WH-4-023_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 pi3k / abl / cell_cyc / other 7_72942379_A_C
147 IFNAR1_5 263_FR-180204_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 erk_mapk / chromatin / mitosis / DNArep 15_84241166_A_C / 6_30642116_A_G / 19_4911043_A_C / 16_259458_T_G / 19_7740447_T_G
148 UEVLD_3 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 DNArep / chromatin / mitosis / rtk 10_11921140_T_G / 11_43920052_A_C / X_2856636_A_C
149 GUF1_5 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 mitosis / igfr / DNArep / chromatin 11_65547388_T_G / 5_181155466_T_G / 1_213007133_T_G / 11_12162199_T_G / 17_55774876_T_G
150 GBP3_1 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 cell_cyc / pi3k / metabol / other 8_7290003_A_C
151 MED28_1 94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 196_Phenformin_3 pi3k / cell_cyc / pi3k / metabol 8_7290003_A_C
152 SLC2A10_1 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 cell_cyc / pi3k / metabol / other 8_7290003_A_C
153 CBR3_1 94_TGX221_3 / 1026_Tanespimycin_2 / 344_THZ-2-49_3 / 196_Phenformin_3 pi3k / other / cell_cyc / metabol 8_7290003_A_C
154 HIC2_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 94_TGX221_3 cell_cyc / other / metabol / pi3k 8_7290003_A_C
155 IGSF9_1 1026_Tanespimycin_2 / 94_TGX221_3 / 196_Phenformin_3 / 344_THZ-2-49_3 other / pi3k / metabol / cell_cyc 8_7290003_A_C
156 RCAN1_1 344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 / 94_TGX221_3 cell_cyc / metabol / other / pi3k 8_7290003_A_C
157 SAFB_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 metabol / cell_cyc / pi3k / other 8_7290003_A_C
158 HNRNPA0_2 1012_Vorinostat_1 / 293_Amuvatinib_2 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 chromatin / rtk / DNArep / apop 17_55774876_T_G / 16_55415_T_G
159 ISL1_1 196_Phenformin_3 / 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 metabol / pi3k / cell_cyc / other 7_72942379_A_C
160 PPIC_1 1012_Vorinostat_1 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 chromatin / igfr / mitosis / erk_mapk 2_66439901_A_C
161 CBX1_1 1011_Navitoclax_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 apop / other / DNArep / mitosis 20_42084724_T_C
162 ARID3B_1 1026_Tanespimycin_2 / 156_AZD6482_2 / 344_THZ-2-49_3 / 196_Phenformin_3 other / pi3k / cell_cyc / metabol 8_7290003_A_C
163 RNF157_1 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 281_Alectinib_2 / 304_SB52334_3 apop / DNArep / rtk / rtk 10_11921140_T_G
164 EIF3L_2 1012_Vorinostat_1 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 chromatin / igfr / DNArep / mitosis 17_51169925_C_T / 20_42084724_T_C
165 SLC25A43_2 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 344_THZ-2-49_3 pi3k / other / metabol / cell_cyc 8_7290003_A_C / 19_7627786_T_G
166 OLFML2A_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 51_Dasatinib_1 metabol / cell_cyc / pi3k / abl 7_72942379_A_C
167 HNRNPA1L2_4 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 1012_Vorinostat_1 mitosis / apop / other / chromatin 2_113934259_C_T / 12_40313960_G_T / 5_181155466_T_G / 12_51745916_T_G
168 GPR125_1 1011_Navitoclax_2 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 apop / rtk / mitosis / other 5_181155466_T_G
169 HFM1_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 mitosis / rtk / apop / DNArep 6_73622013_G_C / 6_73635330_C_T / 10_79312556_A_G / 15_55340661_G_T / 11_12162199_T_G
170 FAM161A_3 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 1009_Tretinoin_1 DNArep / other / apop / other 3_165019547_G_T / 11_65547388_T_G / 7_100104762_T_G
171 MYO1E_5 1012_Vorinostat_1 / 1091_BMS-536924_3 / 281_Alectinib_2 / 221_TAK-715_2 chromatin / igfr / rtk / jnk_p38 12_51745916_T_G / 2_113934259_C_T / 15_40767895_T_G / 8_41957277_G_C / 2_157299566_T_G
172 BHLHE40_2 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 156_AZD6482_2 cell_cyc / metabol / pi3k / pi3k 7_72942379_A_C / 8_7290003_A_C
173 IPO9_1 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 300_CX-5461_3 / 275_I-BET-762_3 DNArep / chromatin / other / chromatin 12_51745916_T_G
174 MALT1_5 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 1091_BMS-536924_3 erk_mapk / mitosis / chromatin / igfr 11_12162199_T_G / 19_4911043_A_C / 12_40313960_G_T / 8_122952205_T_G / 17_7797836_A_C
175 GDPD1_1 179_5-Fluorouracil_1 / 226_GSK1070916_2 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 DNArep / mitosis / other / mitosis 9_69516199_A_C
176 CLIC1_5 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1091_BMS-536924_3 mitosis / rtk / DNArep / igfr 16_1817242_T_C / 13_113159942_A_G / 6_30705800_T_G / 3_128945112_G_A / 5_181155466_T_G
177 GBP1_1 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 304_SB52334_3 mitosis / igfr / igfr / rtk 11_12162199_T_G
178 WDR1_4 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 221_TAK-715_2 mitosis / rtk / DNArep / jnk_p38 13_113159942_A_G / 16_1817242_T_C / 18_79527652_GAA_G / 10_11921140_T_G
179 NOLC1_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 305_TPCA-1_3 chromatin / mitosis / erk_mapk / other 1_234373536_T_G
180 SUCLG2_1 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 304_SB52334_3 / 305_TPCA-1_3 mitosis / apop / rtk / other 2_113934259_C_T
181 TMEM50B_4 1012_Vorinostat_1 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 chromatin / erk_mapk / mitosis / mitosis 15_84241166_A_C / 6_30642116_A_G / 12_40313960_G_T / 10_27223356_T_C
182 TEP1_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 mitosis / other / DNArep / other 13_113159942_A_G / 1_160801918_G_C
183 C1QTNF4_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 300_CX-5461_3 / 304_SB52334_3 DNArep / mitosis / other / rtk 2_108507561_T_G
184 SAMD9_2 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1 mitosis / rtk / igfr / chromatin 11_12162199_T_G / 5_181155466_T_G
185 INTS2_1 226_GSK1070916_2 / 1012_Vorinostat_1 / 225_Genentech Cpd 10_3 / 305_TPCA-1_3 mitosis / chromatin / mitosis / other 20_42084724_T_C
186 FUBP1_1 253_XMD14-99_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 rtk / DNArep / mitosis / chromatin 16_28169801_A_C
187 RPAP1_1 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 304_SB52334_3 / 1012_Vorinostat_1 mitosis / igfr / rtk / chromatin 2_96842345_G_C
188 HEXB_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 metabol / cell_cyc / pi3k / other 15_75876091_T_G
189 HNRNPU_1 305_TPCA-1_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 269_NSC-207895_3 other / chromatin / mitosis / p53 15_65451964_A_G
190 FUCA1_2 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 mitosis / chromatin / chromatin / DNArep 1_153341603_A_C / 11_12162199_T_G
191 NOTCH2_2 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 rtk / mitosis / other / igfr 11_65547388_T_G / 13_113159942_A_G
192 CCT4_1 1012_Vorinostat_1 / 276_CAY10603_3 / 179_5-Fluorouracil_1 / 269_NSC-207895_3 chromatin / chromatin / DNArep / p53 7_108023984_G_A
193 UTRN_3 1012_Vorinostat_1 / 263_FR-180204_3 / 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 chromatin / erk_mapk / igfr / mitosis 7_108023984_G_A / 17_80962613_A_C / 19_4911043_A_C
194 CALU_1 94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 1026_Tanespimycin_2 pi3k / cell_cyc / pi3k / other 7_72942379_A_C
195 PLAUR_1 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 cell_cyc / pi3k / other / metabol 7_72942379_A_C
196 HIST1H3F_2 1012_Vorinostat_1 / 281_Alectinib_2 / 263_FR-180204_3 / 179_5-Fluorouracil_1 chromatin / rtk / erk_mapk / DNArep 9_35398502_T_G / 4_88731303_A_G
197 SHF_2 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1 mitosis / rtk / igfr / chromatin 2_108507561_T_G / 7_149432379_A_C
198 CERK_1 281_Alectinib_2 / 1011_Navitoclax_2 / 300_CX-5461_3 / 253_XMD14-99_3 rtk / apop / other / rtk 2_29320789_A_C
199 TADA1_1 344_THZ-2-49_3 / 156_AZD6482_2 / 159_HG6-64-1_3 / 94_TGX221_3 cell_cyc / pi3k / erk_mapk / pi3k 18_41955194_A_G
200 UBA7_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / other / DNArep / rtk 3_128945112_G_A
201 SETDB1_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 253_XMD14-99_3 DNArep / mitosis / chromatin / rtk 10_11921140_T_G
202 FEV_1 196_Phenformin_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 1057_Dactolisib_2 metabol / cell_cyc / other / pi3k 2_105307612_A_C
203 PLIN3_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 281_Alectinib_2 / 185_Linsitinib_2 mitosis / rtk / rtk / igfr 11_12162199_T_G
204 CAPZB_1 253_XMD14-99_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 rtk / other / DNArep / mitosis 8_109289769_T_C
205 PRR14L_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 mitosis / DNArep / other / other 11_65547388_T_G
206 SYT4_1 281_Alectinib_2 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1091_BMS-536924_3 rtk / mitosis / igfr / igfr 1_247949628_T_C
207 OSTM1_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 293_Amuvatinib_2 mitosis / other / igfr / rtk 11_12162199_T_G
208 ALKBH2_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 293_Amuvatinib_2 chromatin / mitosis / igfr / rtk 11_12162199_T_G / 19_3281403_A_C / 1_228244520_T_G / 16_30953637_A_C / 8_27431326_A_G
209 MSN_1 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 185_Linsitinib_2 igfr / DNArep / chromatin / igfr 10_73803641_A_G
210 ESYT2_2 1012_Vorinostat_1 / 281_Alectinib_2 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 chromatin / rtk / igfr / DNArep 10_73803641_A_G / 19_4911043_A_C
211 RSBN1_1 304_SB52334_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 300_CX-5461_3 rtk / DNArep / other / other 13_113159942_A_G
212 ATL3_1 179_5-Fluorouracil_1 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 DNArep / other / mitosis / igfr 13_113159942_A_G
213 GLCCI1_2 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 281_Alectinib_2 mitosis / rtk / igfr / rtk 16_1817242_T_C / 13_113159942_A_G
214 STX4_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 mitosis / other / rtk / DNArep 13_113159942_A_G
215 ZFP36_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / other / DNArep / rtk 13_113159942_A_G
216 ITPR3_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3 / 196_Phenformin_3 cell_cyc / other / pi3k / metabol 20_33072178_T_G
217 APEX1_1 1012_Vorinostat_1 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 275_I-BET-762_3 chromatin / other / rtk / chromatin 17_55774876_T_G
218 NAGK_1 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 305_TPCA-1_3 chromatin / DNArep / apop / other X_2856636_A_C
219 CTSO_2 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 300_CX-5461_3 DNArep / mitosis / erk_mapk / other 8_2963284_T_G / 19_6937330_T_G
220 GAL3ST3_5 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 mitosis / other / rtk 16_55415_T_G / X_100585180_G_T / 10_79312556_A_G / 19_7740447_T_G / 1_228244520_T_G
221 UBA52_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 mitosis / chromatin / other 13_113159942_A_G / 12_40313960_G_T / 11_65547388_T_G
222 MSRB3_4 304_SB52334_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 rtk / DNArep / mitosis 11_65547388_T_G / 2_108507561_T_G / 12_99655061_T_A / 13_113159942_A_G
223 MTPAP_3 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 DNArep / chromatin / mitosis 1_150261398_T_G / 11_65547388_T_G / 9_128964364_CT_C
224 UBE2O_4 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 chromatin / mitosis / rtk 20_42084724_T_C / 10_11921140_T_G / 6_30705800_T_G / 1_155747580_A_G
225 RANBP17_1 304_SB52334_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 rtk / mitosis / rtk 20_42084724_T_C
226 ZNF516_4 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 DNArep / mitosis / other 17_55774876_T_G / 9_37887606_C_T / 3_184301903_T_G / 1_234373536_T_G
227 NKAIN1_3 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 mitosis / rtk / other 12_40313960_G_T / 13_113159942_A_G / 20_42084724_T_C
228 DHX9_3 269_NSC-207895_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 p53 / other / mitosis 2_113934259_C_T / 15_65451964_A_G / 7_44964464_T_C
229 TET1_4 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 mitosis / rtk / igfr 15_40767895_T_G / 12_51745916_T_G / 2_188994726_T_G / 17_55774876_T_G
230 UHMK1_1 310_YM201636_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / other / mitosis 8_30756677_T_G
231 KCNH8_2 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 pi3k / metabol / other 7_72942379_A_C / 20_62661184_C_T
232 PMEL_1 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 263_FR-180204_3 mitosis / rtk / erk_mapk 20_42084724_T_C
233 TMEM177_2 1012_Vorinostat_1 / 253_XMD14-99_3 / 211_TL-2-105_3 chromatin / rtk / erk_mapk 12_40313960_G_T / 9_108900415_C_A
234 P4HB_3 305_TPCA-1_3 / 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 other / apop / mitosis 6_30329265_T_C / 2_113934259_C_T / 6_39884042_G_A
235 GLB1_2 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 other / mitosis / rtk 1_219979389_T_A / 1_54243266_A_G
236 NIPSNAP1_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 chromatin / mitosis / DNArep 2_86027990_C_A / 5_181155466_T_G / 2_60761746_T_G / 9_37887606_C_T / 12_51745916_T_G
237 STOX2_4 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 304_SB52334_3 mitosis / igfr / rtk 13_113159942_A_G / 11_65547388_T_G / 17_44212322_A_G / 16_1817242_T_C
238 HIC2_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 chromatin / mitosis / DNArep 11_12162199_T_G / 10_11921140_T_G / 5_181155466_T_G / 1_54243266_A_G / 14_67381608_G_T
239 DDX25_1 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 cell_cyc / pi3k / other 7_72942379_A_C
240 DNMT3A_1 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 cell_cyc / pi3k / metabol 7_72942379_A_C
241 EXT2_1 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 cell_cyc / pi3k / metabol 7_72942379_A_C
242 FAM129B_1 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 pi3k / cell_cyc / other 7_72942379_A_C
243 GINM1_1 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 cell_cyc / pi3k / metabol 7_72942379_A_C
244 HNRNPA1L2_1 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 pi3k / cell_cyc / other 7_72942379_A_C
245 MAN1B1_1 94_TGX221_3 / 196_Phenformin_3 / 344_THZ-2-49_3 pi3k / metabol / cell_cyc 7_72942379_A_C
246 TACC1_1 344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 cell_cyc / metabol / other 7_72942379_A_C
247 RIPK1_5 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / DNArep / rtk 11_12162199_T_G / 1_234373536_T_G / 2_190469793_G_C / 16_1817242_T_C / 11_65547388_T_G
248 ZBTB4_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 mitosis / chromatin / DNArep 17_55774876_T_G / 10_11921140_T_G / 6_30705792_T_G
249 TLN1_5 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / DNArep / rtk 15_43578884_A_G / 13_113159942_A_G / 3_128945112_G_A / 11_12162199_T_G / 19_4911043_A_C
250 PCBP3_1 94_TGX221_3 / 51_Dasatinib_1 / 196_Phenformin_3 pi3k / abl / metabol 7_72942379_A_C
251 KIDINS220_2 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 305_TPCA-1_3 mitosis / igfr / other 2_113934259_C_T / 1_113549504_C_T
252 MYH9_4 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 mitosis / chromatin / DNArep 9_69516199_A_C / 13_113159942_A_G / 1_15381304_A_C / 10_11921140_T_G
253 C2orf43_4 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 185_Linsitinib_2 mitosis / erk_mapk / igfr 19_3281403_A_C / 20_42084724_T_C / 12_109800676_G_A / 7_108023984_G_A
254 CFLAR_5 1012_Vorinostat_1 / 304_SB52334_3 / 275_I-BET-762_3 chromatin / rtk / chromatin 17_55774876_T_G / 7_108023984_G_A / 5_181155466_T_G / 1_228244520_T_G / 5_38950065_A_T
255 RAB27A_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 chromatin / mitosis / other 12_6818898_A_C / 16_20737706_A_C / 2_66439901_A_C / 5_181155466_T_G / 11_12162199_T_G
256 PLSCR4_2 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 304_SB52334_3 mitosis / erk_mapk / rtk 16_55415_T_G / 17_51169925_C_T
257 RPUSD4_1 293_Amuvatinib_2 / 1012_Vorinostat_1 / 1091_BMS-536924_3 rtk / chromatin / igfr 15_75524142_T_C
258 MPST_3 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 DNArep / mitosis / chromatin 17_18353665_C_T / 1_150261398_T_G / 5_181155466_T_G
259 MSN_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3 cell_cyc / other / pi3k 8_7290003_A_C
260 TGFB1I1_1 1026_Tanespimycin_2 / 94_TGX221_3 / 344_THZ-2-49_3 other / pi3k / cell_cyc 8_7290003_A_C
261 PRMT1_2 1012_Vorinostat_1 / 263_FR-180204_3 / 221_TAK-715_2 chromatin / erk_mapk / jnk_p38 1_26034759_T_G / 5_181155466_T_G
262 AGPAT3_3 179_5-Fluorouracil_1 / 275_I-BET-762_3 / 265_Tubastatin A_3 DNArep / chromatin / chromatin 11_65547388_T_G / 1_183963850_T_G / 13_113159942_A_G
263 NUPR1_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 272_AR-42_2 mitosis / other / chromatin 11_20049928_A_C / 12_40313960_G_T
264 RNPC3_2 265_Tubastatin A_3 / 179_5-Fluorouracil_1 / 276_CAY10603_3 chromatin / DNArep / chromatin 20_5501817_T_G / 17_55774876_T_G
265 S100A6_2 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 cell_cyc / metabol / pi3k 8_7290003_A_C / 7_72942379_A_C
266 GADD45B_2 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 1012_Vorinostat_1 mitosis / chromatin / chromatin 12_51745916_T_G / 11_12162199_T_G
267 IRF2_2_5 294_MPS-1-IN-1_3 / 269_NSC-207895_3 / 293_Amuvatinib_2 mitosis / p53 / rtk 1_149852603_A_G / 1_219979389_T_A
268 MVP_2_3 94_TGX221_3 / 344_THZ-2-49_3 / 196_Phenformin_3 pi3k / cell_cyc / metabol 11_68780792_C_A / 15_75876091_T_G
269 GTF2H5_2 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 184_BMS-754807_2 mitosis / igfr / igfr 3_165019547_G_T / 16_15664675_G_T
270 AGTPBP1_2 179_5-Fluorouracil_1 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 DNArep / other / mitosis 13_113159942_A_G / 11_65547388_T_G
271 TAGLN2_5 1091_BMS-536924_3 / 1011_Navitoclax_2 / 304_SB52334_3 igfr / apop / rtk 5_181155466_T_G / 12_7433515_G_T / 15_75524142_T_C / 20_2862756_T_G / 19_47441156_T_G
272 CCNT1_4 1012_Vorinostat_1 / 305_TPCA-1_3 / 269_NSC-207895_3 chromatin / other / p53 1_197912561_T_G / 5_115984518_A_T / 8_98032165_T_G / 15_65451964_A_G
273 KCNN4_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 metabol / cell_cyc / pi3k 8_7290003_A_C
274 PEA15_1 196_Phenformin_3 / 94_TGX221_3 / 344_THZ-2-49_3 metabol / pi3k / cell_cyc 8_7290003_A_C
275 SAMD9_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 metabol / cell_cyc / pi3k 8_7290003_A_C
276 TRADD_3 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 DNArep / apop / mitosis 10_11921140_T_G / 13_113159942_A_G / 16_1817242_T_C
277 TAF5_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 mitosis / chromatin / rtk 6_33799054_A_G / 19_3281403_A_C / 7_108023984_G_A
278 EFHD2_4 1091_BMS-536924_3 / 304_SB52334_3 / 281_Alectinib_2 igfr / rtk / rtk 12_51745916_T_G / 1_213007133_T_G / 1_451649_A_AG / 2_61492168_C_A
279 YIPF2_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 1011_Navitoclax_2 mitosis / erk_mapk / apop 2_113934259_C_T
280 ZBED4_2 1012_Vorinostat_1 / 305_TPCA-1_3 / 1011_Navitoclax_2 chromatin / other / apop 2_108507561_T_G / 11_65547388_T_G
281 RAB3C_1 1026_Tanespimycin_2 / 196_Phenformin_3 / 344_THZ-2-49_3 other / metabol / cell_cyc 8_7290003_A_C
282 FOSL1_4 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 275_I-BET-762_3 other / DNArep / chromatin 12_57062993_T_G / 12_51745916_T_G / 13_39724512_C_T / 1_213007133_T_G
283 INA_2 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 mitosis / rtk / erk_mapk 13_113159942_A_G / 16_1817242_T_C
284 FLVCR1_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 253_XMD14-99_3 mitosis / DNArep / rtk 10_11921140_T_G / 11_12162199_T_G
285 ATF7IP2_5 1264_SGC0946_3 / 293_Amuvatinib_2 / 151_QS11_3 chromatin / rtk / other 17_55774876_T_G / 10_73803531_T_C / 2_63887264_C_CA / 3_9789934_A_C / 1_149852603_A_G
286 S100A10_1 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 304_SB52334_3 mitosis / rtk / rtk 10_11921140_T_G
287 TRIP6_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 chromatin / mitosis / igfr 12_51745916_T_G
288 EIF3J_2 1012_Vorinostat_1 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 chromatin / mitosis / p53 17_36429365_A_G / 1_237687398_C_T
289 CASP4_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 275_I-BET-762_3 mitosis / rtk / chromatin 12_51745916_T_G
290 NSL1_2 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 1012_Vorinostat_1 mitosis / apop / chromatin 11_12162199_T_G / 10_11921140_T_G
291 VASP_1 304_SB52334_3 / 294_MPS-1-IN-1_3 / 253_XMD14-99_3 rtk / mitosis / rtk 11_12162199_T_G
292 COG2_3 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 rtk / mitosis / DNArep 10_11921140_T_G / 16_87644643_G_A / 3_53891822_C_T
293 STMN4_3 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 263_FR-180204_3 mitosis / igfr / erk_mapk 13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C
294 ARID2_1 304_SB52334_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 rtk / mitosis / chromatin 11_12162199_T_G
295 TMEM145_2 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 mitosis / igfr / DNArep 10_11921140_T_G / 11_34452090_T_G
296 RPS28_2 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 mitosis / chromatin / other 15_43578884_A_G / 17_18282629_T_G
297 BHLHB9_5 300_CX-5461_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 other / apop / DNArep 2_224001859_C_A / 2_224001670_G_A / 3_128908178_A_G / 13_113159942_A_G / 3_128908109_T_C
298 CCT3_2 94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 pi3k / cell_cyc / pi3k 1_146969331_G_A / 1_16589114_C_T
299 ZBTB39_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 mitosis / DNArep / chromatin 16_30953637_A_C
300 TGFBI_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 253_XMD14-99_3 DNArep / mitosis / rtk 11_12162199_T_G
301 DRAM1_2 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 179_5-Fluorouracil_1 mitosis / chromatin / DNArep 13_113159942_A_G / 12_40313960_G_T
302 TTC9B_4 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 mitosis / rtk / igfr 16_30953637_A_C / 16_1817242_T_C / 13_113159942_A_G / 3_128945112_G_A
303 CRABP1_2 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 263_FR-180204_3 mitosis / igfr / erk_mapk 12_40313960_G_T / 9_69516199_A_C
304 PRNP_1 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 275_I-BET-762_3 mitosis / igfr / chromatin 12_51745916_T_G
305 RNF216_2 344_THZ-2-49_3 / 156_AZD6482_2 / 199_Pazopanib_2 cell_cyc / pi3k / rtk 2_230310834_T_C / 2_230401046_T_C
306 KCNH2_1 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 mitosis / chromatin / erk_mapk 5_38950065_A_T
307 HDAC2_1 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 cell_cyc / metabol / pi3k 15_75876091_T_G
308 LDLRAD3_2 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 mitosis / apop / DNArep 11_65547388_T_G / 1_112653581_C_T
309 DLG2_1 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 mitosis / chromatin / erk_mapk 8_30756677_T_G
310 ABHD2_2 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 mitosis / other / rtk 20_31465452_G_A / 20_31476528_A_G
311 FICD_1 305_TPCA-1_3 / 310_YM201636_3 / 275_I-BET-762_3 other / other / chromatin 12_40313960_G_T
312 EML5_1 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 304_SB52334_3 mitosis / igfr / rtk 19_3281403_A_C
313 ZNF280B_1 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 DNArep / other / apop 11_65547388_T_G
314 MAST1_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 mitosis / rtk / igfr 10_11921140_T_G
315 NBR2_4 1012_Vorinostat_1 / 221_TAK-715_2 / 226_GSK1070916_2 chromatin / jnk_p38 / mitosis 7_142944295_A_G / 7_142939444_T_G / 7_142939502_G_A / 19_3179506_A_C
316 ZSCAN16_1 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 pi3k / cell_cyc / other 16_72119226_C_G
317 CD109_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 mitosis / other / rtk 10_11921140_T_G
318 ASCL1_1 94_TGX221_3 / 196_Phenformin_3 / 156_AZD6482_2 pi3k / metabol / pi3k 7_72942379_A_C
319 PRCC_2 344_THZ-2-49_3 / 94_TGX221_3 / 156_AZD6482_2 cell_cyc / pi3k / pi3k 2_105307612_A_C / 19_8943580_T_G
320 SYPL1_3 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 mitosis / igfr / DNArep 16_1817242_T_C / 3_128945112_G_A / 1_150261398_T_G
321 CACNA1B_3 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 mitosis / apop / DNArep 13_113159942_A_G / X_2856636_A_C / 16_1817242_T_C
322 FEV_3 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 184_BMS-754807_2 igfr / mitosis / igfr 16_1817242_T_C / 13_113159942_A_G / 2_71515762_T_C
323 VSTM2A_2 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 179_5-Fluorouracil_1 mitosis / rtk / DNArep 13_113159942_A_G / 16_1817242_T_C
324 DOC2A_1 179_5-Fluorouracil_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3 DNArep / rtk / mitosis 22_42212334_A_C
325 MTR_1 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 rtk / mitosis / rtk 2_61492168_C_A
326 TMEM184B_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 269_NSC-207895_3 chromatin / mitosis / p53 13_113159942_A_G
327 ARID2_3 344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 cell_cyc / metabol / other 16_72129067_G_T / 16_72164743_G_A / 16_72119226_C_G
328 TSEN54_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 chromatin / mitosis / rtk 13_113325635_A_G / 11_12162199_T_G
329 LAMP2_1 1091_BMS-536924_3 / 1012_Vorinostat_1 / 263_FR-180204_3 igfr / chromatin / erk_mapk 6_33279455_T_G
330 GPX8_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3 cell_cyc / other / pi3k 16_72119226_C_G
331 PRIM1_1 1011_Navitoclax_2 / 1012_Vorinostat_1 / 288_WHI-P97_3 apop / chromatin / other 2_218827668_A_C
332 MMD_3 1012_Vorinostat_1 / 281_Alectinib_2 / 294_MPS-1-IN-1_3 chromatin / rtk / mitosis 1_248441636_T_G / 8_122952205_T_G / 6_30705792_T_G
333 HSPD1_1 1012_Vorinostat_1 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 chromatin / erk_mapk / mitosis 17_55774876_T_G
334 TNFRSF12A_5 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 igfr / DNArep / mitosis 2_60761746_T_G / 11_12162199_T_G / 5_181155466_T_G / 10_50311228_T_G / 13_113159942_A_G
335 PLP2_4 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 igfr / mitosis / apop 8_30756677_T_G / 5_181155466_T_G / 12_104287190_A_G / 6_33296240_C_A
336 SNX3_1 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 226_GSK1070916_2 mitosis / rtk / mitosis 1_248441636_T_G
337 SMC3_1 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 other / mitosis / DNArep 11_65547388_T_G
338 ARHGAP1_1 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 other / DNArep / mitosis 13_113159942_A_G
339 LPP_1 94_TGX221_3 / 1026_Tanespimycin_2 / 1527_Pictilisib_2 pi3k / other / pi3k 18_909560_A_G
340 MGAT1_1 300_CX-5461_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / other / mitosis 13_113159942_A_G
341 TNFRSF1A_3 294_MPS-1-IN-1_3 / 304_SB52334_3 / 281_Alectinib_2 mitosis / rtk / rtk 13_39724512_C_T / 11_65547388_T_G / 17_55774876_T_G
342 C12orf10_1 1091_BMS-536924_3 / 1054_Palbociclib_2 / 1012_Vorinostat_1 igfr / cell_cyc / chromatin 10_73803641_A_G
343 KLF15_1 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 metabol / cell_cyc / pi3k 8_7259511_T_C
344 RSL1D1_1 1012_Vorinostat_1 / 333_T0901317_3 / 276_CAY10603_3 chromatin / other / chromatin 17_55774876_T_G
345 CDK2AP2_1 226_GSK1070916_2 / 275_I-BET-762_3 / 305_TPCA-1_3 mitosis / chromatin / other 13_113159942_A_G
346 ENOX1_1 294_MPS-1-IN-1_3 / 304_SB52334_3 / 275_I-BET-762_3 mitosis / rtk / chromatin 13_113159942_A_G
347 KLHL36_1 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 / 304_SB52334_3 apop / mitosis / rtk 13_113159942_A_G
348 C1R_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / DNArep / rtk 13_113159942_A_G
349 DLL3_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 mitosis / DNArep / rtk 13_113159942_A_G
350 NPC1_1 1012_Vorinostat_1 / 185_Linsitinib_2 / 275_I-BET-762_3 chromatin / igfr / chromatin 6_106621398_T_C
351 BPTF_1 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 DNArep / chromatin / other 17_55774876_T_G
352 CCNB1IP1_1 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 chromatin / DNArep / other 17_55774876_T_G
353 NPC2_1 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 rtk / mitosis / other 13_113159942_A_G
354 ABAT_3 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 igfr / mitosis / igfr 16_24930679_T_G / 3_51381020_A_G / 19_18216930_A_C
355 CEP170_3 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G / 2_218266875_A_C / 11_65547388_T_G
356 NUCB1_3 253_XMD14-99_3 / 294_MPS-1-IN-1_3 rtk / mitosis 15_75524142_T_C / 1_26774532_T_C / 19_3281403_A_C
357 LAMP1_5 1012_Vorinostat_1 / 333_T0901317_3 chromatin / other 1_108718913_T_G / 5_181155466_T_G / 9_108900415_C_A / 2_154259039_T_G / 7_32543154_A_C
358 MAP4_2 94_TGX221_3 / 1026_Tanespimycin_2 pi3k / other 7_72942379_A_C / 8_7290003_A_C
359 MSH6_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 mitosis / other 20_42084724_T_C
360 NECAP2_5 179_5-Fluorouracil_1 / 300_CX-5461_3 DNArep / other 1_45019269_T_G / 13_113159942_A_G / 16_1817242_T_C / 17_55774876_T_G / 9_37887606_C_T
361 RFX7_1 275_I-BET-762_3 / 305_TPCA-1_3 chromatin / other 15_65451964_A_G
362 LOXL1_1 94_TGX221_3 / 344_THZ-2-49_3 pi3k / cell_cyc 7_72942379_A_C
363 RAB11FIP5_1 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 7_72942379_A_C
364 SYNC_1 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 7_72942379_A_C
365 MYT1_2 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 17_41725799_T_G / 20_42084724_T_C
366 CNTNAP2_4 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 2_108507561_T_G / 13_113159942_A_G / X_2856636_A_C / 16_55415_T_G
367 SMARCA5_4 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / mitosis 15_65451964_A_G / 17_81086334_C_G / 11_65547388_T_G / 12_40313960_G_T
368 B3GNT9_4 179_5-Fluorouracil_1 / 1011_Navitoclax_2 DNArep / apop 15_66561152_T_G / 17_55774876_T_G / 11_65547388_T_G / 7_108023984_G_A
369 GAL_2 1012_Vorinostat_1 / 1091_BMS-536924_3 chromatin / igfr 2_66439901_A_C / 9_37887606_C_T
370 TRIM56_5 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 DNArep / mitosis 17_55774876_T_G / 13_113159942_A_G / 20_42084724_T_C / 16_1817242_T_C / 16_30953637_A_C
371 CRIM1_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 mitosis / chromatin 12_40313960_G_T / 1_20724406_A_C / 17_44212322_A_G
372 PNMA3_5 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 mitosis / rtk 2_113934259_C_T / 16_55415_T_G / 20_16044565_T_G / 22_17727059_T_G / 1_149852603_A_G
373 HIST3H2A_3 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 10_11921140_T_G / 16_18379704_T_G / 20_16044565_T_G
374 ATCAY_5 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C / 6_33279455_T_G / 9_5549463_A_C
375 SMARCA4_2 1012_Vorinostat_1 / 1011_Navitoclax_2 chromatin / apop 11_65547388_T_G / 5_181155466_T_G
376 LIN28B_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 5_181155466_T_G / 2_113934259_C_T
377 OLFML2A_5 263_FR-180204_3 / 294_MPS-1-IN-1_3 erk_mapk / mitosis 2_154854926_A_C / 17_7797836_A_C / 6_30705792_T_G / 11_65547388_T_G / 15_84241166_A_C
378 ACP1_5 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 mitosis / apop 19_3281403_A_C / 2_113934259_C_T / 5_181155466_T_G / 2_86604885_C_A / 11_12162199_T_G
379 ACTL6B_3 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 16_1817242_T_C / 13_113159942_A_G / 11_43920052_A_C
380 PHF21B_4 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G / 16_1817242_T_C / 11_12162199_T_G / 16_30953637_A_C
381 BAZ1A_1 1012_Vorinostat_1 / 275_I-BET-762_3 chromatin / chromatin 15_65451964_A_G
382 TMEM30A_1 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 mitosis / igfr 12_104287190_A_G
383 NOL11_2 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 8_7290003_A_C / 1_1918090_A_G
384 BEND4_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 5_181155466_T_G / 6_37022626_A_C / 2_237368621_T_G / 12_6818898_A_C / 12_51745916_T_G
385 ELOVL1_3 185_Linsitinib_2 / 179_5-Fluorouracil_1 igfr / DNArep 13_113159942_A_G / 16_1817242_T_C / 9_37887606_C_T
386 PFKM_4 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 igfr / mitosis 13_20031246_A_C / 9_37887606_C_T / 20_16044565_T_G / 10_79312556_A_G
387 NMNAT1_2 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 15_82519765_A_C / 19_3281403_A_C
388 TIGD1_2 1012_Vorinostat_1 / 179_5-Fluorouracil_1 chromatin / DNArep 17_55774876_T_G / 1_150261398_T_G
389 ARL1_5 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 9_93293047_T_G / 13_113159942_A_G / 12_51745916_T_G / 6_25488355_C_T / 6_25510468_CAT_C
390 CPLX1_4 263_FR-180204_3 / 294_MPS-1-IN-1_3 erk_mapk / mitosis 16_1817242_T_C / 13_113159942_A_G / 16_30953637_A_C / 18_79527652_GAA_G
391 PAX6_5 1012_Vorinostat_1 / 263_FR-180204_3 chromatin / erk_mapk 1_234309145_T_G / 1_156286332_T_G / 1_54243266_A_G / 12_44376791_T_A / 10_50311228_T_G
392 ANXA2_5 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 apop / mitosis 12_57178583_A_C / 2_86604885_C_A / 5_181155466_T_G / 6_33296240_C_A / 8_30756677_T_G
393 BHLHE41_1 305_TPCA-1_3 / 185_Linsitinib_2 other / igfr 2_113934259_C_T
394 DPYSL5_2 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G / 2_108507561_T_G
395 NCL_5 1012_Vorinostat_1 / 305_TPCA-1_3 chromatin / other 17_55774876_T_G / 19_3281403_A_C / 7_108023984_G_A / 11_65547388_T_G / 13_113159942_A_G
396 NEK6_3 294_MPS-1-IN-1_3 / 185_Linsitinib_2 mitosis / igfr 11_12162199_T_G / 13_39724512_C_T / 10_50311228_T_G
397 ADAM11_1 253_XMD14-99_3 / 294_MPS-1-IN-1_3 rtk / mitosis 9_128964364_CT_C
398 BMP1_1 94_TGX221_3 / 196_Phenformin_3 pi3k / metabol 7_72942379_A_C
399 CRABP1_1 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 7_72942379_A_C
400 CREB3_1 94_TGX221_3 / 344_THZ-2-49_3 pi3k / cell_cyc 7_72942379_A_C
401 CTSB_1 196_Phenformin_3 / 94_TGX221_3 metabol / pi3k 7_72942379_A_C
402 GLB1_1 196_Phenformin_3 / 94_TGX221_3 metabol / pi3k 7_72942379_A_C
403 LGALS3_1 196_Phenformin_3 / 94_TGX221_3 metabol / pi3k 7_72942379_A_C
404 SMPD1_1 94_TGX221_3 / 344_THZ-2-49_3 pi3k / cell_cyc 7_72942379_A_C
405 GTPBP4_1 263_FR-180204_3 / 1012_Vorinostat_1 erk_mapk / chromatin 12_40313960_G_T
406 ACTR3B_2 294_MPS-1-IN-1_3 / 310_YM201636_3 mitosis / other 13_113159942_A_G / 5_170034543_C_T
407 CSRP1_3 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 10_11921140_T_G / 2_27774175_G_T / 17_55774876_T_G
408 SEPHS1_1 1012_Vorinostat_1 / 305_TPCA-1_3 chromatin / other 2_113934259_C_T
409 ACTN2_1 253_XMD14-99_3 / 294_MPS-1-IN-1_3 rtk / mitosis 1_213007133_T_G
410 NMRK1_2 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 mitosis / chromatin 12_7433515_G_T / 16_55415_T_G
411 TFAP2A_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 erk_mapk / mitosis 3_165019547_G_T
412 CAV1_3 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 mitosis / chromatin 17_81086334_C_G / 13_39724512_C_T / 12_51745916_T_G
413 PQLC3_2 1012_Vorinostat_1 / 179_5-Fluorouracil_1 chromatin / DNArep 10_11921140_T_G / 16_18379704_T_G
414 RPL9_4 179_5-Fluorouracil_1 / 305_TPCA-1_3 DNArep / other 11_12162199_T_G / 3_165019547_G_T / 11_65547388_T_G / 16_72788732_T_G
415 H2AFY2_3 185_Linsitinib_2 / 294_MPS-1-IN-1_3 igfr / mitosis 10_11921140_T_G / 1_213007133_T_G / 11_12162199_T_G
416 MCM10_1 1011_Navitoclax_2 / 1012_Vorinostat_1 apop / chromatin 2_170965958_A_C
417 G6PD_1 179_5-Fluorouracil_1 / 300_CX-5461_3 DNArep / other 16_87644643_G_A
418 TADA1_1 179_5-Fluorouracil_1 / 1012_Vorinostat_1 DNArep / chromatin 10_11921140_T_G
419 KCNC1_5 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 16_30953637_A_C / 9_5549463_A_C / 17_76472531_A_C / 11_43920052_A_C / 16_1817242_T_C
420 JPH4_1 294_MPS-1-IN-1_3 / 281_Alectinib_2 mitosis / rtk 12_40313960_G_T
421 ZNF121_3 263_FR-180204_3 / 179_5-Fluorouracil_1 erk_mapk / DNArep 13_113159942_A_G / 16_1817242_T_C / 11_12162199_T_G
422 TMEM206_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 9_69516199_A_C
423 HS3ST4_1 179_5-Fluorouracil_1 / 300_CX-5461_3 DNArep / other 3_128945112_G_A
424 MRPL48_1 1264_SGC0946_3 / 1012_Vorinostat_1 chromatin / chromatin 5_181155466_T_G
425 PPAT_5 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 mitosis / chromatin 8_27431326_A_G / 1_228244520_T_G / 6_56557393_C_T / 1_46261223_G_A / 1_234373536_T_G
426 CELF3_3 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 3_128908109_T_C / 16_1817242_T_C / 3_128945112_G_A
427 ABCC8_1 294_MPS-1-IN-1_3 / 281_Alectinib_2 mitosis / rtk 3_128945112_G_A
428 KIF1C_4 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 13_113159942_A_G / 19_43359207_C_A / 16_1817242_T_C / 9_93293047_T_G
429 MOSPD2_1 263_FR-180204_3 / 1012_Vorinostat_1 erk_mapk / chromatin 11_12162199_T_G
430 ANKRD46_1 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 10_11921140_T_G
431 RSL24D1_1 1012_Vorinostat_1 / 1091_BMS-536924_3 chromatin / igfr 9_69516199_A_C
432 HNRNPC_1 94_TGX221_3 / 196_Phenformin_3 pi3k / metabol 8_7290003_A_C
433 LYST_1 196_Phenformin_3 / 94_TGX221_3 metabol / pi3k 8_7290003_A_C
434 MRPS31_2 304_SB52334_3 / 1012_Vorinostat_1 rtk / chromatin 1_112520503_A_G / 11_65547388_T_G
435 ANXA11_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 DNArep / mitosis 16_1817242_T_C
436 GABRB3_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 13_113159942_A_G / 16_1817242_T_C
437 ITGB5_4 179_5-Fluorouracil_1 / 1012_Vorinostat_1 DNArep / chromatin 2_154854926_A_C / 1_234373536_T_G / 11_65547388_T_G / 17_55774876_T_G
438 TAGLN_5 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 2_157299566_T_G / 22_18345007_A_C / 1_54243266_A_G / 1_156286332_T_G / X_49565582_A_C
439 KLF6_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 mitosis / other 12_95474188_T_G
440 GLIS3_1 344_THZ-2-49_3 / 196_Phenformin_3 cell_cyc / metabol 8_7290003_A_C
441 GRPEL2_3 1012_Vorinostat_1 / 179_5-Fluorouracil_1 chromatin / DNArep 9_108900415_C_A / 5_133233474_T_G / 10_11921140_T_G
442 SORCS1_2 294_MPS-1-IN-1_3 / 281_Alectinib_2 mitosis / rtk 16_259458_T_G / 13_113159942_A_G
443 TAF3_1 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 15_75876091_T_G
444 ZNF638_4 304_SB52334_3 / 269_NSC-207895_3 rtk / p53 10_73803531_T_C / 13_39724512_C_T / 22_17727059_T_G / 5_427675_T_C
445 RPAIN_2 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 9_69516199_A_C / 11_18089364_C_A
446 PRMT6_2 275_I-BET-762_3 / 305_TPCA-1_3 chromatin / other 7_35240878_C_T / 3_53872486_G_A
447 CERCAM_1 1012_Vorinostat_1 / 305_TPCA-1_3 chromatin / other 6_30705792_T_G
448 TWSG1_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 12_51745916_T_G
449 NAP1L1_1 305_TPCA-1_3 / 272_AR-42_2 other / chromatin 7_2269556_T_A
450 NQO2_1 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 DNArep / mitosis 10_79312556_A_G
451 EXOSC5_1 1012_Vorinostat_1 / 179_5-Fluorouracil_1 chromatin / DNArep 7_108023984_G_A
452 LTBP2_1 196_Phenformin_3 / 344_THZ-2-49_3 metabol / cell_cyc 11_68780792_C_A
453 KIAA1549_3 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 17_75834935_G_A / 15_40855887_C_T / 15_40855965_C_T
454 LRP10_2 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 11_65547388_T_G / 17_55774876_T_G
455 CIB1_4 185_Linsitinib_2 / 1012_Vorinostat_1 igfr / chromatin 13_113159942_A_G / 1_150261398_T_G / 16_1817242_T_C / 1_149852603_A_G
456 RPL19_1 1012_Vorinostat_1 / 226_GSK1070916_2 chromatin / mitosis 2_61492168_C_A
457 CBX2_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 10_73803641_A_G / 17_80352778_T_G
458 CLVS2_2 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 igfr / mitosis 2_108507561_T_G / 11_65547388_T_G
459 GLIPR1_2 1012_Vorinostat_1 / 179_5-Fluorouracil_1 chromatin / DNArep 19_4911043_A_C / 10_11921140_T_G
460 TAPBP_3 294_MPS-1-IN-1_3 / 275_I-BET-762_3 mitosis / chromatin 11_12162199_T_G / 16_30953637_A_C / 12_40313960_G_T
461 GNA12_3 179_5-Fluorouracil_1 / 300_CX-5461_3 DNArep / other 13_113325626_T_C / 7_129389033_T_G / 12_51745916_T_G
462 MBNL1_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 9_69516199_A_C
463 ISYNA1_2 344_THZ-2-49_3 / 156_AZD6482_2 cell_cyc / pi3k 15_43716974_A_C / 3_197683305_A_C
464 PRLHR_2 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 10_26746549_C_T / 6_56067480_C_T
465 IQGAP1_5 1091_BMS-536924_3 / 1012_Vorinostat_1 igfr / chromatin 8_122952205_T_G / 3_128945112_G_A / 13_113325635_A_G / 19_9566733_T_G / 5_181155466_T_G
466 SDC4_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 12_40313960_G_T / 13_113159942_A_G
467 NAA25_1 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 7_108023984_G_A
468 PLEKHA4_1 294_MPS-1-IN-1_3 / 226_GSK1070916_2 mitosis / mitosis 7_2269556_T_A
469 TUBA4A_2 1012_Vorinostat_1 / 1091_BMS-536924_3 chromatin / igfr 7_159142364_T_G / 11_65547388_T_G
470 SLC35D1_1 293_Amuvatinib_2 / 1012_Vorinostat_1 rtk / chromatin 16_18379704_T_G
471 SH3GLB1_1 1012_Vorinostat_1 / 1011_Navitoclax_2 chromatin / apop 20_42084724_T_C
472 RPL37_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 mitosis / other 11_12162199_T_G
473 KDELR3_3 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 16_72119226_C_G / 16_72129067_G_T / 16_72164743_G_A
474 DDX60L_1 1011_Navitoclax_2 / 179_5-Fluorouracil_1 apop / DNArep 11_12162199_T_G
475 GNPDA2_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 3_191358113_C_T
476 DPY30_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 14_23276467_A_G
477 MURC_2 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 apop / mitosis 17_73203001_T_G / 8_61583890_T_A
478 CCDC80_2 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 16_72119226_C_G / 16_72129067_G_T
479 C12orf23_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 16_72119226_C_G
480 LOX_1 344_THZ-2-49_3 / 94_TGX221_3 cell_cyc / pi3k 16_72119226_C_G
481 CEP68_3 185_Linsitinib_2 / 304_SB52334_3 igfr / rtk 13_113159942_A_G / 8_12430448_C_T / 17_55774876_T_G
482 BEND3_1 196_Phenformin_3 / 344_THZ-2-49_3 metabol / cell_cyc 15_75876091_T_G
483 RPRD2_3 156_AZD6482_2 / 344_THZ-2-49_3 pi3k / cell_cyc 1_146975626_G_A / 1_146969331_G_A / 1_148117837_C_T
484 ELAVL4_3 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G / 7_108023984_G_A / 7_108024001_C_T
485 TRIM21_1 294_MPS-1-IN-1_3 / 253_XMD14-99_3 mitosis / rtk 1_237687398_C_T
486 PRPF40B_1 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 mitosis / igfr 17_64146068_T_G
487 DCLRE1A_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 1_219979389_T_A
488 DUSP12_1 1012_Vorinostat_1 / 304_SB52334_3 chromatin / rtk 15_75524142_T_C
489 TFPI_2 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 mitosis / apop 1_213007133_T_G / 16_1817242_T_C
490 MYO1C_2 1011_Navitoclax_2 / 304_SB52334_3 apop / rtk 11_65547388_T_G / 13_113159942_A_G
491 SYDE1_1 94_TGX221_3 / 344_THZ-2-49_3 pi3k / cell_cyc 18_41955194_A_G
492 RANBP1_1 1012_Vorinostat_1 / 288_WHI-P97_3 chromatin / other 6_30705792_T_G
493 PRAME_3 179_5-Fluorouracil_1 / 1009_Tretinoin_1 DNArep / other 16_67909562_C_A / 22_42212334_A_C / 19_57720377_A_G
494 PNN_1 305_TPCA-1_3 / 179_5-Fluorouracil_1 other / DNArep 13_39724512_C_T
495 PHF11_3 300_CX-5461_3 / 305_TPCA-1_3 other / other 11_12162199_T_G / X_2856636_A_C / X_119150617_A_C
496 WDR35_1 185_Linsitinib_2 / 294_MPS-1-IN-1_3 igfr / mitosis 12_109800676_G_A
497 KCNN4_5 1091_BMS-536924_3 / 1012_Vorinostat_1 igfr / chromatin 5_181155466_T_G / 20_45938939_T_G / 10_11921140_T_G / 1_15381304_A_C / 10_50311228_T_G
498 SERPINB6_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 2_227062473_GT_G
499 ACOT9_5 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 mitosis / igfr 10_11921140_T_G / 11_12162199_T_G / 3_128945112_G_A / 13_113159942_A_G / 6_29631350_A_G
500 LAMP1_2 344_THZ-2-49_3 / 196_Phenformin_3 cell_cyc / metabol 1_99728613_A_C / 7_72942379_A_C
501 C19orf10_2 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 16_72129067_G_T / 16_72119226_C_G
502 EHD2_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 6_10410133_T_G
503 DPH5_1 1012_Vorinostat_1 / 1054_Palbociclib_2 chromatin / cell_cyc 8_12430448_C_T
504 TMEM169_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 1_112520503_A_G
505 SMARCB1_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 3_197683305_A_C
506 PLEKHF2_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 7_108023984_G_A
507 HSF2_5 179_5-Fluorouracil_1 / 1011_Navitoclax_2 DNArep / apop 11_65547388_T_G / 2_178663651_C_T / 1_234373536_T_G / 16_67878678_T_G / 2_178689190_G_A
508 ASPH_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 2_105307612_A_C
509 SERINC3_1 344_THZ-2-49_3 / 196_Phenformin_3 cell_cyc / metabol 2_105307612_A_C
510 THOC5_1 196_Phenformin_3 / 344_THZ-2-49_3 metabol / cell_cyc 3_197683305_A_C
511 SLC6A15_1 253_XMD14-99_3 / 294_MPS-1-IN-1_3 rtk / mitosis 17_55774876_T_G
512 TBC1D2_1 1012_Vorinostat_1 / 305_TPCA-1_3 chromatin / other 1_185150475_G_A
513 HSPG2_1 344_THZ-2-49_3 / 51_Dasatinib_1 cell_cyc / abl 1_37703244_A_C
514 CACNA2D2_1 294_MPS-1-IN-1_3 / 185_Linsitinib_2 mitosis / igfr 17_76472531_A_C
515 SLC5A6_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 7_108023984_G_A / 14_22844242_T_G
516 DAZAP1_2 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 chromatin / mitosis 6_73622013_G_C / 6_73635330_C_T
517 NFIX_2 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 10_101004037_A_C / 12_109800676_G_A
518 ELAVL3_3 196_Phenformin_3 / 344_THZ-2-49_3 metabol / cell_cyc 2_15474280_T_C / 2_15475786_A_G / 2_15467718_T_C
519 COPB2_1 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 19_16503339_T_G
520 ZNF219_1 1026_Tanespimycin_2 / 156_AZD6482_2 other / pi3k 15_43716974_A_C
521 RNF165_2 294_MPS-1-IN-1_3 / 281_Alectinib_2 mitosis / rtk 10_11921140_T_G / 16_1817242_T_C
522 P4HA1_1 1011_Navitoclax_2 / 281_Alectinib_2 apop / rtk 16_58525116_G_T
523 CIB2_3 344_THZ-2-49_3 / 1026_Tanespimycin_2 cell_cyc / other 11_33583339_C_T / 11_33583414_C_T / 11_33606557_T_G
524 LMAN2_1 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / mitosis 11_65547388_T_G
525 POFUT1_1 1026_Tanespimycin_2 / 104_Bortezomib_1 other / other 4_118640836_A_T
526 ITGB1_1 94_TGX221_3 / 344_THZ-2-49_3 pi3k / cell_cyc 20_46216899_A_C
527 GFPT2_2 156_AZD6482_2 / 94_TGX221_3 pi3k / pi3k 7_72942379_A_C / 1_12938859_G_A
528 SNTB2_2 1026_Tanespimycin_2 / 94_TGX221_3 other / pi3k 5_36985201_A_G / 5_37000972_A_G
529 FAM126A_1 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 1_451649_A_AG
530 FAM214B_1 1012_Vorinostat_1 / 345_KIN001-270_3 chromatin / cell_cyc 20_24959779_A_C
531 E2F5_1 1012_Vorinostat_1 / 221_TAK-715_2 chromatin / jnk_p38 19_16896123_T_G
532 CRMP1_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G
533 DTX3L_1 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 13_113159942_A_G
534 ELAVL3_1 304_SB52334_3 / 294_MPS-1-IN-1_3 rtk / mitosis 13_113159942_A_G
535 GATA2_1 294_MPS-1-IN-1_3 / 185_Linsitinib_2 mitosis / igfr 13_113159942_A_G
536 GNG4_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G
537 GPX8_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G
538 LATS2_1 294_MPS-1-IN-1_3 / 304_SB52334_3 mitosis / rtk 13_113159942_A_G
539 TMEM87B_1 1011_Navitoclax_2 / 304_SB52334_3 apop / rtk 1_237687398_C_T
540 NR2C1_1 305_TPCA-1_3 / 1091_BMS-536924_3 other / igfr 9_88647472_G_A
541 CHMP4B_1 333_T0901317_3 / 1012_Vorinostat_1 other / chromatin 16_66912991_CGT_C
542 HPDL_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 mitosis / DNArep 6_41770599_T_G
543 HNRPDL_1 1012_Vorinostat_1 / 1011_Navitoclax_2 chromatin / apop 17_55774876_T_G
544 MICB_1 275_I-BET-762_3 / 304_SB52334_3 chromatin / rtk 17_81086334_C_G
545 C17orf53_5 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk 3_128481377_A_C / 7_142940415_T_G / 17_74777339_T_G / X_24788994_C_T / 19_39885857_T_G
546 WDR3_1 276_CAY10603_3 / 1012_Vorinostat_1 chromatin / chromatin 5_88722571_GA_G
547 FKBP15_1 196_Phenformin_3 / 344_THZ-2-49_3 metabol / cell_cyc 2_200493236_A_C
548 SLC22A23_1 94_TGX221_3 pi3k 7_72942379_A_C
549 ST6GALNAC3_1 344_THZ-2-49_3 cell_cyc 7_72942379_A_C
550 RCAN1_3 1012_Vorinostat_1 chromatin 11_65547388_T_G / 2_66439901_A_C / 7_159142364_T_G
551 CCDC107_2 94_TGX221_3 pi3k 7_72942379_A_C / 20_62661184_C_T
552 PAX6_2 94_TGX221_3 pi3k 7_72942379_A_C / 7_5227302_G_C
553 IGSF9_5 1012_Vorinostat_1 chromatin 16_87644643_G_A / 5_181155466_T_G / 13_113325635_A_G / 12_6818898_A_C / 11_12162199_T_G
554 TFAP4_2 1012_Vorinostat_1 chromatin 5_181155466_T_G / 11_65547388_T_G
555 B2M_5 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 12_6818898_A_C / 20_42084724_T_C / 1_108718913_T_G / 3_128945112_G_A
556 ZCCHC12_1 1166_QL-VIII-58_3 tor 1_1676790_C_T
557 MYL12B_3 294_MPS-1-IN-1_3 mitosis 2_108507561_T_G / X_38285780_G_A / 1_237687398_C_T
558 SHPRH_5 179_5-Fluorouracil_1 DNArep 11_65547388_T_G / 17_55774876_T_G / 2_108507561_T_G / 22_42212334_A_C / 13_113159942_A_G
559 NRSN1_4 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C / 9_93293047_T_G
560 HNRNPR_3 288_WHI-P97_3 other 17_40348252_T_G / 10_101004037_A_C / 17_73203001_T_G
561 RRAGC_2 263_FR-180204_3 erk_mapk 9_37887606_C_T / 10_79312556_A_G
562 CTSA_3 1012_Vorinostat_1 chromatin 11_12162199_T_G / 5_181155466_T_G / 16_87644643_G_A
563 DUSP26_3 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 15_43578884_A_G / 16_1817242_T_C
564 IFI35_2 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 16_30953637_A_C
565 FAM163A_4 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C / 6_33279455_T_G / 20_16044565_T_G / 2_113934259_C_T
566 DHX15_3 294_MPS-1-IN-1_3 mitosis 1_26774532_T_C / 19_3281403_A_C / 11_12162199_T_G
567 WDR86_3 305_TPCA-1_3 other 16_87644643_G_A / 20_42084724_T_C / 19_9566733_T_G
568 CECR5_1 1012_Vorinostat_1 chromatin 5_181155466_T_G
569 VASH2_1 1012_Vorinostat_1 chromatin 5_181155466_T_G
570 KCNH8_2 294_MPS-1-IN-1_3 mitosis 3_100302035_G_T / 2_169735166_A_C
571 MRPS25_3 179_5-Fluorouracil_1 DNArep 15_75524142_T_C / 9_37887606_C_T / 1_213007133_T_G
572 COPS7B_4 1012_Vorinostat_1 chromatin 10_11921140_T_G / 19_3281403_A_C / 1_150261398_T_G / 10_97048952_T_G
573 PHYHIPL_2 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_30953637_A_C
574 ATP6V0E1_3 294_MPS-1-IN-1_3 mitosis 12_40313960_G_T / 11_12162199_T_G / 15_43211582_A_C
575 CEP44_5 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 10_11921140_T_G / 17_55774876_T_G / 11_65547388_T_G / 10_27223356_T_C
576 SEC22C_1 305_TPCA-1_3 other 15_65451964_A_G
577 TRIM38_2 294_MPS-1-IN-1_3 mitosis 15_43578884_A_G / 17_51169925_C_T
578 MTF2_1 1026_Tanespimycin_2 other 7_72942379_A_C
579 ZC3H15_4 263_FR-180204_3 erk_mapk 2_154854926_A_C / 7_149253814_T_G / 20_63929447_G_C / 3_196782572_G_T
580 THOC5_2 1012_Vorinostat_1 chromatin 1_54243266_A_G / 22_22098988_G_T
581 CLASP2_2 185_Linsitinib_2 igfr 9_37887606_C_T / 16_1817242_T_C
582 SLC18A2_2 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C / 10_101004037_A_C
583 NDUFAF4_4 1012_Vorinostat_1 chromatin 11_65547388_T_G / 1_234373536_T_G / 15_65451964_A_G / 15_75524142_T_C
584 CHD4_1 1012_Vorinostat_1 chromatin 12_51745916_T_G
585 KIF5A_3 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C / 11_12162199_T_G / 1_20724406_A_C
586 CNN2_2 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 11_94082585_T_C
587 DCBLD1_2 294_MPS-1-IN-1_3 mitosis 10_26746549_C_T / 11_12162199_T_G
588 SPSB4_2 304_SB52334_3 rtk 15_55340661_G_T / 15_55329691_T_C
589 EDIL3_1 263_FR-180204_3 erk_mapk 11_12162199_T_G
590 GALNT10_3 294_MPS-1-IN-1_3 mitosis 6_30705792_T_G / 11_65547388_T_G / 12_40313960_G_T
591 H1FX_1 294_MPS-1-IN-1_3 mitosis 11_73355795_A_G
592 OSGIN1_4 275_I-BET-762_3 chromatin 4_61579528_T_C / 3_53871281_T_C / 3_53872486_G_A / 3_53888593_A_G
593 PRRX1_1 94_TGX221_3 pi3k 10_96527504_G_C
594 SERF2_1 1012_Vorinostat_1 chromatin 12_52013974_A_C
595 PPP1CC_3 1012_Vorinostat_1 chromatin 10_11921140_T_G / 1_185150475_G_A / 11_124896232_A_G
596 SYDE1_2 179_5-Fluorouracil_1 DNArep 11_65547388_T_G / 13_113159942_A_G
597 C11orf74_2 294_MPS-1-IN-1_3 mitosis 12_124473081_C_T / 19_17205202_T_G
598 NEFH_1 294_MPS-1-IN-1_3 mitosis 16_55415_T_G
599 MPPE1_2 294_MPS-1-IN-1_3 mitosis 1_160801918_G_C / 6_10410133_T_G
600 RAC3_1 281_Alectinib_2 rtk 20_42084724_T_C
601 XRCC2_1 1011_Navitoclax_2 apop 2_219297298_T_G
602 PVRL2_2 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 11_12162199_T_G
603 JAKMIP1_3 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_1817242_T_C / 6_33279455_T_G
604 RETSAT_2 305_TPCA-1_3 other 1_113900413_C_G / 10_43200831_A_G
605 ECSIT_4 1012_Vorinostat_1 chromatin 19_4911043_A_C / 2_60761746_T_G / 11_43920052_A_C / 12_6818898_A_C
606 KCTD11_5 263_FR-180204_3 erk_mapk 11_65547388_T_G / 14_93183653_A_C / 13_113159942_A_G / 1_54243266_A_G / 17_7797836_A_C
607 NOL4_1 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C
608 PHACTR3_1 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C
609 RTN1_1 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C
610 STMN2_1 294_MPS-1-IN-1_3 mitosis 16_30953637_A_C
611 AP2S1_2 304_SB52334_3 rtk 2_61492168_C_A / 2_27774175_G_T
612 ZFYVE21_1 179_5-Fluorouracil_1 DNArep 22_42212334_A_C
613 UNC13A_1 1026_Tanespimycin_2 other 2_105307612_A_C
614 HRH3_2 294_MPS-1-IN-1_3 mitosis 3_128945112_G_A / 6_33279455_T_G
615 SLC46A3_1 275_I-BET-762_3 chromatin 11_12162199_T_G
616 FANCF_1 226_GSK1070916_2 mitosis 2_61492168_C_A
617 NUP188_1 1011_Navitoclax_2 apop 17_73203001_T_G
618 RASL11B_4 294_MPS-1-IN-1_3 mitosis 5_181155466_T_G / 11_73355795_A_G / 1_220067324_T_G / 9_126483890_T_G
619 RPL35A_1 253_XMD14-99_3 rtk 1_145961089_T_G
620 MRPS34_2 263_FR-180204_3 erk_mapk 6_32035203_A_C / 22_22098988_G_T
621 GIMAP2_3 179_5-Fluorouracil_1 DNArep 1_155709773_T_G / 16_87644643_G_A / 12_51745916_T_G
622 CEP290_2 305_TPCA-1_3 other 15_65451964_A_G / 12_57062993_T_G
623 GLTPD1_2 300_CX-5461_3 other 1_44339331_A_G / 9_37887606_C_T
624 GPHN_2 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 13_39724512_C_T
625 CASP1_1 294_MPS-1-IN-1_3 mitosis 12_40313960_G_T
626 ZNF696_1 294_MPS-1-IN-1_3 mitosis 12_40313960_G_T
627 PUM2_1 294_MPS-1-IN-1_3 mitosis 19_3281403_A_C
628 MEIS1_3 179_5-Fluorouracil_1 DNArep 13_113159942_A_G / 17_36608462_A_C / 16_29836801_T_G
629 IFI30_1 269_NSC-207895_3 p53 16_55415_T_G
630 IL11RA_1 1012_Vorinostat_1 chromatin 10_11921140_T_G
631 NUCB2_1 1012_Vorinostat_1 chromatin 10_11921140_T_G
632 PTP4A3_1 1012_Vorinostat_1 chromatin 10_11921140_T_G
633 ADRBK2_2 294_MPS-1-IN-1_3 mitosis 11_65547388_T_G / 17_78476773_C_T
634 PKIG_3 156_AZD6482_2 pi3k 10_47523038_G_A / 10_46337735_A_G / 2_105307612_A_C
635 SET_2 1011_Navitoclax_2 apop 2_113934259_C_T / 7_44964464_T_C
636 FLII_4 294_MPS-1-IN-1_3 mitosis 12_51745916_T_G / 1_213007133_T_G / 16_1342948_A_C / 2_86027990_C_A
637 ARF6_1 300_CX-5461_3 other 1_173850301_T_G
638 HMGCR_1 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C
639 ST8SIA3_1 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C
640 UNC80_1 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C
641 CCT8_3 1012_Vorinostat_1 chromatin 7_108024001_C_T / 8_61583890_T_A / 7_108023984_G_A
642 TRIM28_1 1012_Vorinostat_1 chromatin 19_40695973_T_G
643 CDC25A_2 1011_Navitoclax_2 apop 19_9566733_T_G / 14_55169342_TAAA_T
644 GLTP_2 1012_Vorinostat_1 chromatin 2_61492168_C_A / 1_149852603_A_G
645 CCDC77_1 1012_Vorinostat_1 chromatin 7_108023984_G_A
646 MCF2L_1 1091_BMS-536924_3 igfr 15_43578884_A_G
647 SLC6A2_2 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C / 13_113159942_A_G
648 SYP_2 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_1817242_T_C
649 CNOT6_1 1012_Vorinostat_1 chromatin 15_75524142_T_C
650 VARS_1 1012_Vorinostat_1 chromatin 15_75524142_T_C
651 IFITM3_4 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_1817242_T_C / 7_149253814_T_G / 8_27431326_A_G
652 PEX5_1 1091_BMS-536924_3 igfr 2_96842345_G_C
653 SLC31A2_2 196_Phenformin_3 metabol 2_171833908_C_T / 2_171744206_C_A
654 GRIK3_1 294_MPS-1-IN-1_3 mitosis 3_128945112_G_A
655 VN1R1_1 294_MPS-1-IN-1_3 mitosis 1_213007133_T_G
656 TFB2M_1 1012_Vorinostat_1 chromatin 6_32002466_A_C
657 MAD2L1_1 1011_Navitoclax_2 apop 19_9566733_T_G
658 MCM7_1 1011_Navitoclax_2 apop 19_9566733_T_G
659 MLF1IP_1 1011_Navitoclax_2 apop 19_9566733_T_G
660 RFC3_1 1011_Navitoclax_2 apop 19_9566733_T_G
661 RPL13A_5 1012_Vorinostat_1 chromatin 4_145127510_C_T / 12_57470756_A_G / 15_45095024_A_C / 19_44985182_T_G / 20_47227145_T_G
662 LINGO2_5 221_TAK-715_2 jnk_p38 12_51745916_T_G / 17_737856_G_T / 10_74988957_T_G / 3_113344632_A_C / 4_173528913_A_G
663 DNAJC22_1 1011_Navitoclax_2 apop 15_75268724_T_G
664 LAPTM4B_5 1012_Vorinostat_1 chromatin 13_19425701_C_A / 7_117129719_T_G / 2_131597280_C_G / 1_54243276_T_G / 20_34850996_A_C
665 MRPL21_1 1012_Vorinostat_1 chromatin 22_22098988_G_T
666 KBTBD6_5 304_SB52334_3 rtk 11_65547388_T_G / 5_141478412_T_C / 13_113159942_A_G / 2_108507561_T_G / 6_30705792_T_G
667 ENDOD1_1 1012_Vorinostat_1 chromatin 5_80744593_A_C
668 DYNLT3_1 1012_Vorinostat_1 chromatin 16_70661204_T_G
669 FBXO33_3 253_XMD14-99_3 rtk 6_25488355_C_T / 6_25510468_CAT_C / 4_144114635_G_A
670 MAGT1_3 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 6_29631350_A_G / 10_11921140_T_G
671 RAP2C_1 253_XMD14-99_3 rtk 19_4911043_A_C
672 UNC13A_4 294_MPS-1-IN-1_3 mitosis 6_37282313_A_C / 16_1817242_T_C / 10_11921140_T_G / 13_113159942_A_G
673 MFAP5_1 150_Bicalutamide_1 other 9_18775833_A_C
674 CUX2_2 294_MPS-1-IN-1_3 mitosis 11_12162199_T_G / 8_122952205_T_G
675 MED25_5 1012_Vorinostat_1 chromatin 17_18282776_T_G / 11_74492398_A_C / 19_1460944_T_G / 1_224418353_A_C / X_54813054_T_G
676 MYT1L_2 294_MPS-1-IN-1_3 mitosis 16_1817242_T_C / 15_43211582_A_C
677 TMEM18_2 176_IPA-3_3 cytoskeleton 2_54968084_G_A / 2_55027029_T_A
678 CCT7_1 1012_Vorinostat_1 chromatin 12_40313960_G_T
679 MAK16_1 1012_Vorinostat_1 chromatin 12_40313960_G_T
680 MRPS21_1 1012_Vorinostat_1 chromatin 12_40313960_G_T
681 POLR1B_1 1012_Vorinostat_1 chromatin 12_40313960_G_T
682 GTPBP1_2 333_T0901317_3 other 9_37887606_C_T / 11_43920052_A_C
683 EBF3_1 294_MPS-1-IN-1_3 mitosis 9_5549463_A_C
684 MTUS1_2 1012_Vorinostat_1 chromatin 19_53998273_G_A / 19_53999532_G_A
685 NUP133_2 179_5-Fluorouracil_1 DNArep 10_11921140_T_G / 11_12162199_T_G
686 CTNND1_2 294_MPS-1-IN-1_3 mitosis 6_30705800_T_G / 9_69516199_A_C
687 NDUFB9_1 1012_Vorinostat_1 chromatin 19_4911043_A_C
688 SLC9A7_1 1012_Vorinostat_1 chromatin 19_4911043_A_C
689 EIF4ENIF1_1 1091_BMS-536924_3 igfr 9_37887606_C_T
690 DOCK1_1 196_Phenformin_3 metabol 8_94407470_A_G
691 RPL32_1 300_CX-5461_3 other 8_12430448_C_T
692 PRICKLE2_1 185_Linsitinib_2 igfr 11_65547388_T_G
693 RUFY3_1 185_Linsitinib_2 igfr 11_65547388_T_G
694 WNT5A_1 185_Linsitinib_2 igfr 11_65547388_T_G
695 MPHOSPH10_2 275_I-BET-762_3 chromatin 15_75524142_T_C / 12_40313960_G_T
696 ARID3A_1 344_THZ-2-49_3 cell_cyc 8_7290003_A_C
697 HBQ1_1 344_THZ-2-49_3 cell_cyc 8_7290003_A_C
698 CAPG_5 305_TPCA-1_3 other 11_12162199_T_G / 10_11921140_T_G / 20_45938939_T_G / 1_156286332_T_G / 15_75783033_T_G
699 YARS2_2 1012_Vorinostat_1 chromatin 4_41632760_G_C / 4_41631305_C_A
700 KIAA0247_5 269_NSC-207895_3 p53 1_149852603_A_G / 17_55774876_T_G / 16_18379704_T_G / 7_114630022_T_G / 19_15191478_T_G
701 ATP6V1A_1 1012_Vorinostat_1 chromatin 9_69516199_A_C
702 NFXL1_3 179_5-Fluorouracil_1 DNArep 17_55774876_T_G / 1_228244520_T_G / 20_16044565_T_G
703 RIOK3_3 293_Amuvatinib_2 rtk 2_61492168_C_A / 19_4679822_A_C / 1_1918305_G_A
704 AKR7A2_4 281_Alectinib_2 rtk 1_213007133_T_G / 17_55774876_T_G / 17_15651252_T_G / 1_451649_A_AG
705 THOC1_3 305_TPCA-1_3 other 1_44804312_T_G / 17_5474687_A_C / 8_68625531_T_G
706 COPG_1 1026_Tanespimycin_2 other 6_26897081_G_C
707 RPL13_1 185_Linsitinib_2 igfr 20_42084724_T_C
708 ARRB2_2 179_5-Fluorouracil_1 DNArep 2_170965958_A_C / 20_33848655_A_C
709 CCDC41_2 269_NSC-207895_3 p53 9_86322936_ATTT_A / 9_86345023_C_T
710 WDR75_5 1012_Vorinostat_1 chromatin 3_196782572_G_T / 1_154331414_T_G / 7_149253814_T_G / 2_190469793_G_C / 18_14183954_G_T
711 LRBA_4 1011_Navitoclax_2 apop 13_114236659_T_G / 11_65547388_T_G / 2_178769713_G_T / 13_113159942_A_G
712 BAI3_2 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 6_30705792_T_G
713 FKBP4_1 1012_Vorinostat_1 chromatin 13_113325635_A_G
714 H3F3B_1 1012_Vorinostat_1 chromatin 13_113325635_A_G
715 LRRC45_1 281_Alectinib_2 rtk 17_6118065_A_G
716 VPRBP_1 1011_Navitoclax_2 apop 3_128945112_G_A
717 KIF1A_1 294_MPS-1-IN-1_3 mitosis 9_69516199_A_C
718 RPL3_1 294_MPS-1-IN-1_3 mitosis 2_24067801_G_A
719 ABI3BP_1 1012_Vorinostat_1 chromatin 16_87644643_G_A
720 FBRSL1_1 1091_BMS-536924_3 igfr 10_11921140_T_G
721 RAB3C_1 294_MPS-1-IN-1_3 mitosis 10_11921140_T_G
722 C16orf59_1 1012_Vorinostat_1 chromatin 19_9566733_T_G
723 NUP35_1 263_FR-180204_3 erk_mapk 19_9566733_T_G
724 LPIN2_1 344_THZ-2-49_3 cell_cyc 3_191357867_G_A
725 ZNF507_2 305_TPCA-1_3 other 11_65547388_T_G / 17_55774876_T_G
726 ADAM10_1 344_THZ-2-49_3 cell_cyc 17_63963708_T_C
727 FBXL18_1 344_THZ-2-49_3 cell_cyc 17_63963708_T_C
728 TMOD3_1 344_THZ-2-49_3 cell_cyc 17_63963708_T_C
729 HLCS_3 263_FR-180204_3 erk_mapk 14_67381608_G_T / 15_84241166_A_C / 17_43922689_A_G
730 NYNRIN_1 293_Amuvatinib_2 rtk 10_11921140_T_G
731 PDXK_1 344_THZ-2-49_3 cell_cyc 16_72164743_G_A
732 RPS11_3 1012_Vorinostat_1 chromatin 4_145127510_C_T / 17_28613683_A_C / 8_12430448_C_T
733 LCE2B_1 94_TGX221_3 pi3k 10_133753622_G_A
734 MAP2K7_3 1012_Vorinostat_1 chromatin 1_11243090_T_G / 12_109952676_A_C / 21_46245172_A_C
735 PATZ1_1 1012_Vorinostat_1 chromatin 11_12162199_T_G
736 SMCR7L_1 1012_Vorinostat_1 chromatin 11_12162199_T_G
737 CNTNAP2_1 196_Phenformin_3 metabol 8_7290003_A_C
738 SLC29A3_1 196_Phenformin_3 metabol 8_7290003_A_C
739 ZBTB34_1 185_Linsitinib_2 igfr 3_165019547_G_T
740 PRKAA1_2 294_MPS-1-IN-1_3 mitosis X_100585180_G_T / 3_128945112_G_A
741 IRF1_2 294_MPS-1-IN-1_3 mitosis 17_55774876_T_G / 12_51745916_T_G
742 GDAP1L1_5 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G / 16_1817242_T_C / 11_125626705_T_G / 9_128835995_A_C / 7_20404680_T_G
743 NUP205_2 290_KIN001-260_3 other 15_78476214_A_G / 10_19491534_C_A
744 NUS1_1 1011_Navitoclax_2 apop 1_147618935_T_C
745 GOLT1B_3 344_THZ-2-49_3 cell_cyc 16_72119226_C_G / 16_72129067_G_T / 16_72164743_G_A
746 SEC24A_2 1026_Tanespimycin_2 other 15_28382572_T_C / 7_5308283_G_A
747 AVEN_1 94_TGX221_3 pi3k 7_75422659_A_G
748 BRD3_1 1011_Navitoclax_2 apop 2_113934259_C_T
749 CBX5_1 1011_Navitoclax_2 apop 2_113934259_C_T
750 ZNF689_1 1012_Vorinostat_1 chromatin 3_53183591_A_C
751 RHOG_5 1194_SB-505124_3 other 5_427675_T_C / 16_1817242_T_C / 13_113159942_A_G / 16_30398066_C_A / 2_121418676_T_G
752 SPRY1_4 224_AS605240_3 pi3k 3_121642799_G_A / 3_121634481_A_C / 3_121699918_T_C / 3_121642940_G_A
753 NR1H2_2 1011_Navitoclax_2 apop 1_154627925_A_C / 1_150261398_T_G
754 RTKN2_1 294_MPS-1-IN-1_3 mitosis 6_73644452_C_T
755 CHRNA5_1 294_MPS-1-IN-1_3 mitosis 6_10410133_T_G
756 PEBP1_1 1011_Navitoclax_2 apop 4_108762737_T_G
757 CNOT6_1 196_Phenformin_3 metabol 1_16589114_C_T
758 FEM1B_1 263_FR-180204_3 erk_mapk 1_151048750_A_C
759 PDCD2L_1 151_QS11_3 other 2_196880031_T_C
760 BCCIP_2 1012_Vorinostat_1 chromatin 1_219979389_T_A / 19_11402175_A_C
761 C17orf80_2 344_THZ-2-49_3 cell_cyc 16_72119226_C_G / 16_72129067_G_T
762 TMEM229A_1 1012_Vorinostat_1 chromatin 6_30705792_T_G
763 AKAP1_1 344_THZ-2-49_3 cell_cyc 16_72119226_C_G
764 EPC2_1 344_THZ-2-49_3 cell_cyc 16_72119226_C_G
765 FKBP14_1 344_THZ-2-49_3 cell_cyc 16_72119226_C_G
766 HMGB1_1 344_THZ-2-49_3 cell_cyc 16_72119226_C_G
767 TMEM167B_1 344_THZ-2-49_3 cell_cyc 16_72119226_C_G
768 FURIN_1 281_Alectinib_2 rtk 2_113934259_C_T
769 FUZ_2 1012_Vorinostat_1 chromatin 10_73803641_A_G / 17_6118065_A_G
770 RAX_1 94_TGX221_3 pi3k 14_64951601_A_C
771 HSPA5_1 344_THZ-2-49_3 cell_cyc 1_165652085_TATTATC_T
772 SEZ6_1 294_MPS-1-IN-1_3 mitosis 3_128879626_CGT_C
773 CDC7_2 1011_Navitoclax_2 apop 6_73622013_G_C / 6_73635330_C_T
774 TIMELESS_2 1011_Navitoclax_2 apop 2_218827668_A_C / 20_48700966_A_C
775 FAIM2_1 294_MPS-1-IN-1_3 mitosis 3_127621040_A_G
776 PKIA_1 275_I-BET-762_3 chromatin 13_113159942_A_G
777 MRFAP1L1_1 304_SB52334_3 rtk 11_12162199_T_G
778 SLC4A8_1 1011_Navitoclax_2 apop 6_33296240_C_A
779 SAMM50_1 344_THZ-2-49_3 cell_cyc 17_76009153_A_C
780 FAM129A_1 263_FR-180204_3 erk_mapk 13_113159942_A_G
781 AFMID_5 1012_Vorinostat_1 chromatin 14_70800628_C_T / 12_6941768_C_A / 11_12162199_T_G / 3_119147558_G_A / 3_196782572_G_T
782 STARD7_1 344_THZ-2-49_3 cell_cyc 21_31701881_A_G
783 GPN2_2 300_CX-5461_3 other 17_55774876_T_G / 1_451649_A_AG
784 PCDH9_1 344_THZ-2-49_3 cell_cyc 3_75669056_G_A
785 DDOST_2 344_THZ-2-49_3 cell_cyc 1_16589114_C_T / 6_10398408_A_G
786 TMEM109_3 179_5-Fluorouracil_1 DNArep 13_113159942_A_G / 16_30398066_C_A / 5_141102658_A_C
787 OLA1_2 196_Phenformin_3 metabol 1_148117837_C_T / 1_146969331_G_A
788 RGS3_4 344_THZ-2-49_3 cell_cyc 2_241748788_C_T / 2_241748877_C_T / 2_241751260_G_A / 2_241744700_T_C
789 HMGCL_1 344_THZ-2-49_3 cell_cyc 1_16589114_C_T
790 SIPA1L1_1 344_THZ-2-49_3 cell_cyc 1_16589114_C_T
791 TMEM50A_1 344_THZ-2-49_3 cell_cyc 1_16589114_C_T
792 AP2S1_2 196_Phenformin_3 metabol 7_100951952_T_A / 7_100951953_T_A
793 NARF_1 304_SB52334_3 rtk 5_83553308_T_G
794 S100A2_2 1011_Navitoclax_2 apop 11_65547388_T_G / 17_55774876_T_G
795 STX8_2 94_TGX221_3 pi3k 7_100951952_T_A / 7_100951953_T_A
796 SLC10A4_3 1011_Navitoclax_2 apop 6_30329265_T_C / 16_1817242_T_C / 12_51745916_T_G
797 KCNAB1_1 294_MPS-1-IN-1_3 mitosis 19_17205202_T_G
798 NUFIP1_1 294_MPS-1-IN-1_3 mitosis 1_112520503_A_G
799 PUS7_1 1011_Navitoclax_2 apop 11_65547388_T_G
800 TMEM33_1 1011_Navitoclax_2 apop 11_65547388_T_G
801 SUPT4H1_1 281_Alectinib_2 rtk 1_247949628_T_C
802 B4GALT1_2 185_Linsitinib_2 igfr 13_113159942_A_G / 11_65547388_T_G
803 TRMT1_1 344_THZ-2-49_3 cell_cyc 12_8176004_A_C
804 ITCH_1 344_THZ-2-49_3 cell_cyc 1_13281477_A_G
805 SLC41A2_1 1527_Pictilisib_2 pi3k 4_118640836_A_T
806 UBXN1_1 1091_BMS-536924_3 igfr 10_73803641_A_G
807 AARS2_1 293_Amuvatinib_2 rtk 2_211420614_AAAAG_A
808 ASB13_1 1012_Vorinostat_1 chromatin 17_28613683_A_C
809 CSDA_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
810 DBH_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
811 DOK4_1 185_Linsitinib_2 igfr 13_113159942_A_G
812 FAM57B_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
813 GRIA4_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
814 IGFBPL1_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
815 NFKBIZ_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
816 PIEZO1_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
817 SCN3B_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
818 SNAP91_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
819 TMEM151B_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
820 TRAM1_1 294_MPS-1-IN-1_3 mitosis 13_113159942_A_G
821 DLGAP2_1 294_MPS-1-IN-1_3 mitosis 6_33279455_T_G
822 GFRA2_2 1011_Navitoclax_2 apop 5_38950065_A_T / 16_30953637_A_C
823 C12orf44_5 1011_Navitoclax_2 apop 8_72935904_A_T / 8_23202743_T_C / 15_40296801_A_G / 8_23201811_C_G / 9_134768529_A_G
824 CPD_2 1091_BMS-536924_3 igfr 16_30953637_A_C / 9_108900415_C_A
825 UNG_3 1011_Navitoclax_2 apop 7_108023984_G_A / 4_70722781_C_T / 3_52437514_T_G
826 AGAP2_1 263_FR-180204_3 erk_mapk 10_77108446_G_A
827 DPY19L4_1 294_MPS-1-IN-1_3 mitosis 7_149253814_T_G
828 UST_1 294_MPS-1-IN-1_3 mitosis 4_70722781_C_T
829 MAP2K7_1 344_THZ-2-49_3 cell_cyc 1_16734496_C_T
830 DLG1_1 344_THZ-2-49_3 cell_cyc 3_197683305_A_C
831 MAPK8IP2_1 185_Linsitinib_2 igfr 6_25669441_G_A
832 TARDBP_3 1011_Navitoclax_2 apop 11_65547388_T_G / 22_42212334_A_C / 15_65451964_A_G
833 CYLD_1 294_MPS-1-IN-1_3 mitosis 17_40348252_T_G
834 ATL2_1 294_MPS-1-IN-1_3 mitosis 3_38112112_T_G
835 SCAMP5_1 294_MPS-1-IN-1_3 mitosis X_100585180_G_T
836 ARL6IP5_1 196_Phenformin_3 metabol 14_102870248_A_C
837 TUBD1_1 276_CAY10603_3 chromatin 1_161021085_T_C
838 OLFM3_1 294_MPS-1-IN-1_3 mitosis 10_43200831_A_G
839 ODC1_2 310_YM201636_3 other 1_44339337_G_A / 15_75524142_T_C
840 EXOSC8_4 1011_Navitoclax_2 apop 6_73622013_G_C / 6_73635330_C_T / 2_127651579_A_C / 6_30705792_T_G
841 GEMIN5_4 1012_Vorinostat_1 chromatin 9_104837455_A_G / 8_42401781_A_G / 1_46261223_G_A / 15_72662708_A_C
842 BCLAF1_1 269_NSC-207895_3 p53 11_65547388_T_G
843 ADAMTSL2_3 294_MPS-1-IN-1_3 mitosis 14_20996722_T_G / 8_122952205_T_G / 9_136745293_A_C
844 GSDMD_1 196_Phenformin_3 metabol 8_143559981_G_GAGGGCAGGGC
845 FILIP1L_1 344_THZ-2-49_3 cell_cyc 2_117977926_TAGTC_T
846 MPP5_1 344_THZ-2-49_3 cell_cyc 16_10941900_CGAA_C
847 ZNF781_2 1011_Navitoclax_2 apop 6_30705792_T_G / 11_65547388_T_G
848 GREB1_1 294_MPS-1-IN-1_3 mitosis 11_65547388_T_G
849 MICAL2_1 294_MPS-1-IN-1_3 mitosis 11_65547388_T_G
850 MLKL_1 304_SB52334_3 rtk 17_55774876_T_G
851 HIATL1_1 333_T0901317_3 other 1_13816508_A_G
852 POFUT2_3 344_THZ-2-49_3 cell_cyc 16_72119226_C_G / 16_72164743_G_A / 7_95495738_CT_C
853 FSD1L_3 1011_Navitoclax_2 apop 13_113159942_A_G / 11_12162199_T_G / 11_65547388_T_G
854 SLC22A4_1 294_MPS-1-IN-1_3 mitosis 2_60761746_T_G
855 ECE1_1 344_THZ-2-49_3 cell_cyc 3_196484004_T_C
856 FAM120C_1 179_5-Fluorouracil_1 DNArep 1_206458298_T_G
857 WDR18_1 1012_Vorinostat_1 chromatin 1_64663808_A_C
858 SPAST_2 305_TPCA-1_3 other 14_68291858_T_C / 4_158607939_A_AT
859 RIN2_1 344_THZ-2-49_3 cell_cyc 2_15474280_T_C
860 RUNX2_2 185_Linsitinib_2 igfr 11_12162199_T_G / 15_75268724_T_G
861 NOP14_2 1012_Vorinostat_1 chromatin 17_3513849_GCA_G / 9_36058818_G_T
862 MAN2B2_1 1012_Vorinostat_1 chromatin 17_55774876_T_G
863 PAIP1_1 344_THZ-2-49_3 cell_cyc 1_112659795_G_A
864 DHX32_2 344_THZ-2-49_3 cell_cyc X_119469587_A_G / X_119451980_A_G
865 PLK2_2 344_THZ-2-49_3 cell_cyc 3_9688859_C_T / 5_127331576_G_A
866 PRCC_1 1012_Vorinostat_1 chromatin 4_9908299_G_A
867 XAF1_1 344_THZ-2-49_3 cell_cyc 2_197498780_A_G
868 METAP2_1 344_THZ-2-49_3 cell_cyc 2_208237181_GA_G
869 CLK2_1 294_MPS-1-IN-1_3 mitosis 2_230875561_A_G
870 DPP6_1 294_MPS-1-IN-1_3 mitosis 19_43375573_G_T
871 ACSL4_3 344_THZ-2-49_3 cell_cyc 11_33583339_C_T / 11_33583414_C_T / 11_33606557_T_G
872 ANKIB1_1 1012_Vorinostat_1 chromatin 2_218827668_A_C
873 MRPL44_1 263_FR-180204_3 erk_mapk 10_11921140_T_G
874 ECSIT_1 344_THZ-2-49_3 cell_cyc 2_105307612_A_C
875 UTRN_1 344_THZ-2-49_3 cell_cyc 2_105307612_A_C
876 KLHL3_1 94_TGX221_3 pi3k 3_10062127_TA_T
877 PPP3CC_1 1011_Navitoclax_2 apop 15_77916965_T_C
878 ZNF146_2 276_CAY10603_3 chromatin 13_113159942_A_G / 3_196782572_G_T
879 ZNF561_1 156_AZD6482_2 pi3k 2_9954863_A_G
880 GABRB3_2 196_Phenformin_3 metabol 2_15474280_T_C / 2_15534562_T_C
881 FUCA2_2 294_MPS-1-IN-1_3 mitosis 1_185150475_G_A / X_54813054_T_G
882 ZNF704_1 196_Phenformin_3 metabol 11_120836935_C_T
883 RSRC2_1 179_5-Fluorouracil_1 DNArep 11_43920052_A_C
884 ZNF786_4 1166_QL-VIII-58_3 tor 16_72119226_C_G / 16_72164743_G_A / 16_72129067_G_T / 16_72150667_C_T
885 FAM208A_4 344_THZ-2-49_3 cell_cyc 1_103021838_CT_C / 8_7290003_A_C / 1_103002059_C_T / 1_102989661_C_T
886 KLC1_2 179_5-Fluorouracil_1 DNArep 6_30705792_T_G / 9_35801627_T_G
887 C4orf46_1 1011_Navitoclax_2 apop 1_44804312_T_G
888 PFDN2_1 1012_Vorinostat_1 chromatin 1_200988322_T_G
889 TMEM88_1 304_SB52334_3 rtk 15_63286530_C_T
890 CAMKMT_1 1009_Tretinoin_1 other 3_165019547_G_T
891 RAB3A_5 1091_BMS-536924_3 igfr 1_149852603_A_G / 15_75293000_T_G / 16_15664675_G_T / 1_150261398_T_G / 13_113325635_A_G
892 PPP1R3C_1 1012_Vorinostat_1 chromatin 1_172308705_AT_A
893 RNPS1_1 1012_Vorinostat_1 chromatin 6_26033581_T_TAAG
894 SESN1_1 185_Linsitinib_2 igfr 8_93815432_A_C
뇌종양(brain) 약물에 대한 바이오 마커의 반응성 검증 결과
No. FRH Var_Exp(pval) Var_Drug(pval) Exp_Drug(pval) Ave_VarDrug(pval) Rank
1 PTRF_9 2.02E-17 0.000749693 / 0.000426098 / 0.009328967 / 0.000372589 / 0.006511221 / 2.35E-11 / 0.000116605 / 0.001047505 / 0.001374062 / 0.001565845 / 0.006047479 / 7.32E-05 / 0.006557575 / 9.01E-05 / 0.000574879 / 0.000160684 / 2.49E-05 / 0.002310424 / 0.000331474 / 0.000819278 / 9.28E-12 / 0.002957218 / 0.007844904 / 0.002619813 / 0.000685764 / 3.28E-05 / 0.007149858 / 1.82E-05 / 0.004659546 / 0.004062417 / 0.000187819 / 2.07E-07 / 0.004167431 / 0.001265165 / 0.002575563 / 0.000839515 / 0.008965476 / 0.00033059 / 4.72E-05 / 0.001888735 / 0.00646848 / 0.000714169 / 2.80E-07 / 0.001294695 / 0.000115716 / 3.08E-06 / 0.000261232 / 0.001910231 / 1.28E-06 / 0.004145356 / 0.003060428 / 0.006977625 / 0.001419304 / 7.63E-09 / 0.009439533 / 0.003871906 / 0.00072755 / 3.06E-06 / 0.003623857 / 0.001340666 / 0.008077047 / 0.000197417 / 0.003726859 / 0.001744921 / 0.006814012 / 0.007768596 / 0.001018135 8.86E-05 / 0.015861427 / 0.000935884 / 6.69E-06 / 0.001642604 / 7.15E-09 / 0.000114128 / 0.005567682 / 0.001713376 / 0.003771243 / 0.001845691 / 6.63E-05 / 0.000313526 / 0.002067719 / 0.000456029 / 0.003684593 / 5.74E-06 / 0.002204168 / 0.000228633 / 0.000400518 / 6.03E-07 / 0.000743512 / 0.012226314 / 0.024250323 / 8.17E-07 / 0.000107275 / 0.068108214 / 1.05E-05 / 0.245827021 / 0.000690655 / 0.00029549 / 3.30E-06 / 0.000963538 / 0.000798032 / 0.000737892 / 0.005284786 / 0.003534303 / 8.80E-05 / 0.004403153 / 0.004222642 / 0.006563798 / 0.000101882 / 5.52E-08 / 0.000895926 / 4.32E-06 / 2.39E-05 / 0.012076982 / 0.000700794 / 4.02E-08 / 0.000551546 / 0.005498224 / 0.005843004 / 0.004771885 / 7.03E-09 / 0.000449732 / 0.00773881 / 0.00481047 / 2.17E-06 / 0.029515032 / 2.54E-05 / 0.001228246 / 0.001095519 / 0.018900662 / 0.000306042 / 1.61E-05 / 0.007260065 / 0.036785468 0.00244 67
2 MBTD1_5 0.0000000000 6.079058529181583e-06 / 0.000330234961590499 / 0.0009065836837091153 / 7.743250099097525e-08 / 5.4243318683013945e-06 / 6.638871076180972e-05 / 0.0001034540386175869 / 2.742943691390761e-05 / 8.864763064813537e-07 / 2.0409664165250274e-05 / 0.0014603495105780778 / 0.0002106217117458753 / 0.0020461746255640493 / 0.0008861613640617831 / 0.0014909983720721473 / 0.001580303435076526 / 0.00012171542819902834 2.8823341263186404e-09 / 7.828409458693464e-09 / 8.294895004123309e-09 / 3.2262810582910645e-08 / 1.8139300001511646e-07 / 1.8402518116440838e-07 / 2.67841045277985e-07 / 1.5039088850140218e-06 / 1.3222940844102726e-06 / 1.2562395947292494e-06 / 0.00019219761010832952 / 8.314417317729093e-07 / 1.370078882045095e-05 / 6.768156840167973e-06 / 1.0455349186526601e-05 / 2.2476152083519155e-06 / 3.022593119181365e-06 0.000545 17
3 C12orf29_4 0.0000000000 4.824002117845577e-08 / 0.005441831791967279 / 1.1897498080889868e-05 / 2.832726371483715e-06 / 3.554190719208408e-05 / 9.98122338478244e-05 / 0.00019780761336601855 / 1.2166594948453657e-06 / 0.0013399032530365647 / 0.010366551109197954 9.831623775837906e-08 / 1.1424232521759333e-06 / 4.317636814226818e-05 / 1.4382106269639384e-06 / 1.565031148370116e-06 / 0.0001061775620019226 / 7.880009857538694e-07 / 5.059091238516106e-06 / 6.9124096914811e-05 / 3.7455065294802056e-05 0.00175 10
4 DDX20_1 0.0000010604 9.390951294242489e-05 / 0.003291125326808141 / 6.606509042863372e-05 / 0.0009706006123489501 / 0.00033173858745018413 / 2.8301251379202592e-05 / 0.002989009151291833 / 0.0003464118358647972 / 4.611763366846969e-05 / 0.010271987936204268 1.8690130781974698e-08 / 1.7049356788275527e-06 / 4.90739703689557e-07 / 2.1664146971003018e-07 / 2.2579476817862133e-07 / 2.2223004763773554e-07 / 1.487681859612425e-06 / 5.806089896300099e-06 / 5.518438170954557e-07 / 3.9629751093887545e-06 0.001844 10
5 TACC1_4 0.0000000000 3.87018819160593e-07 / 7.839796663490128e-06 / 0.0211517389620851 / 0.0007385583772737821 / 0.0001541124146376614 / 0.000740753187661269 / 0.00010956462066226552 / 0.0005066082079176534 / 0.00031180764933246263 / 0.0002656005692813481 1.8794101118497154e-10 / 5.932840218364882e-08 / 1.3308222183335375e-05 / 3.6611240087061e-07 / 1.9891885346261133e-06 / 2.780203755383467e-06 / 7.920522224234305e-06 / 4.233437731609824e-05 / 1.3783248323482445e-06 / 8.71500241588669e-06 0.002399 10
6 SFPQ_1 0.0000000779 4.611763366846969e-05 / 6.606509042863372e-05 / 9.390951294242489e-05 / 0.0021892065422244767 / 0.002989009151291833 / 2.8301251379202592e-05 / 0.006770110957154303 / 0.003291125326808141 / 0.00018869114988485987 / 0.023379270483941148 1.6421685468372866e-11 / 2.7347777767986492e-08 / 6.012098925210058e-08 / 2.202165084592466e-05 / 9.663054308166113e-05 / 8.127505856380939e-07 / 1.0837751787086504e-05 / 8.284871105188379e-05 / 1.8339230937241138e-06 / 7.704856579616509e-05 0.003904 10
7 LRPPRC_2 0.0000000013 1.2022019578742027e-05 / 0.0003761548279529811 / 0.0037244088642669265 / 0.0021708592883619747 / 0.0001663224278721914 / 0.023108708224531857 / 2.9430765473148166e-05 / 0.01050357293743899 / 0.020115537840238746 / 0.010524107924498233 5.209483330257566e-10 / 8.01050796462614e-08 / 2.4695473842016646e-07 / 8.371111187295495e-08 / 5.106669850809745e-07 / 4.686091200519956e-06 / 1.3349886552198077e-08 / 1.915969698573113e-06 / 2.9107217405524718e-06 / 2.5997671669797386e-05 0.007073 10
8 ILF3_5 0.0000000000 1.3887956173777372e-05 / 1.6939519588941488e-05 / 9.786382578515826e-08 / 0.0007340541171379744 / 3.1279199929494124e-06 / 9.697231213241931e-06 / 0.0003946275449128456 / 0.0013987772568790748 / 0.0011249003808451194 1.7515743716180326e-07 / 3.0845658986771253e-07 / 6.542843309537432e-09 / 1.1331609020935322e-06 / 4.268164739909969e-07 / 1.315856013252508e-05 / 7.875046335838071e-06 / 4.114385321933064e-07 / 2.3594761771202245e-05 0.000411 9
9 ATXN7L3B_5 0.0000000000 2.612066597760477e-06 / 0.00011479613384953161 / 7.334368900690378e-11 / 0.0010577852528073678 / 9.018479144369487e-06 / 9.409687610838478e-05 / 0.003583481340909988 / 1.7599872572764645e-05 / 0.0008387169638839557 2.969448250016487e-08 / 1.9600165258234536e-07 / 4.2990302404127387e-08 / 2.1159749013263597e-06 / 1.0277412362510468e-05 / 2.2327592321063564e-05 / 2.749246019785697e-06 / 2.702131319979186e-05 / 6.193347041468136e-06 0.000635 9
10 CENPV_1 0.0000001156 0.006820424547488444 / 1.2412020538304333e-05 / 0.004148676908553548 / 0.005770181686062503 / 0.019668015814206605 / 0.0025299472548494955 / 0.005078710464709388 / 0.0004338260851758113 / 0.03879612345050204 1.6083375617695613e-06 / 1.8297985260415566e-08 / 5.676604686582581e-08 / 4.561722639281827e-07 / 2.7263615702723626e-06 / 6.194080837624687e-07 / 1.2533181199972694e-06 / 0.00011131713990719029 / 4.864543347378877e-07 0.009251 9
11 CAMKV_4 0.0000000014 5.551416714792332e-06 / 0.0008366625106022517 / 0.0005748885432290085 / 2.2091746366723067e-05 / 0.0012478612516330242 / 0.0013687527180138105 / 1.5647557069044988e-05 / 5.021668210368932e-05 4.61338946784834e-09 / 8.552882219336728e-06 / 1.2084936819520143e-05 / 7.064438585065973e-06 / 0.0003375551467252637 / 1.1640523808727713e-05 / 7.01115214482234e-05 / 4.699480658072907e-05 0.000515 8
12 TPMT_3 0.0000000000 7.28786952864283e-07 / 3.56646279188718e-05 / 9.6666658281473e-06 / 0.000778043526031782 / 0.0009044201128473978 / 0.0021692955083051683 / 0.0005370416183224255 / 9.028956735669806e-05 1.4274492942468779e-08 / 1.0767623030922322e-08 / 5.322824205944157e-10 / 6.914371271776401e-08 / 3.193252019194024e-06 / 3.3380153156051058e-06 / 1.3843642927526513e-06 / 1.514974348380039e-05 0.000566 8
13 WASF1_3 0.0000000001 3.6965068162525554e-06 / 0.0012954933098786366 / 1.5026939104998247e-05 / 6.092048706938309e-06 / 5.7827307263502816e-05 / 3.710694976569371e-08 / 2.4065055735879793e-06 / 0.0066209312465568835 1.8963621043904114e-06 / 1.942674022825637e-09 / 1.4008670359077526e-07 / 7.984757203592169e-07 / 1.807601980567127e-06 / 1.014708711120146e-06 / 9.411427127533182e-07 / 2.7376810453016147e-06 0.001 8
14 DDX25_4 0.0000000000 4.227069860488674e-06 / 1.1933180927019854e-06 / 1.275889510970952e-05 / 0.00014312717982028765 / 0.0001971578481272282 / 0.0007128346948758641 / 0.005660294390019774 / 0.002987411679461687 5.868503968366881e-07 / 1.6672256393335718e-07 / 7.607024358338446e-07 / 4.007532632723821e-06 / 5.422908721198046e-06 / 4.226087433911996e-06 / 1.9844578914555127e-05 / 1.348050130807739e-05 0.001215 8
15 ACVR2B_5 0.0000000000 0.00031701458152281776 / 4.014660005410256e-05 / 8.837943468799988e-05 / 1.2223170855538867e-05 / 0.00417544874823594 / 0.00027313653971257405 / 0.006738885955615125 / 0.00033890163674631904 4.22669945715201e-07 / 7.742783641708327e-10 / 2.0483971869730718e-07 / 1.239958147162055e-07 / 4.939171357902516e-05 / 4.120212263097594e-06 / 0.0006361321771264191 / 2.7380093694423655e-05 0.001498 8
16 TAP1_4 0.0000000000 1.049031460757783e-06 / 0.0003635757182364942 / 3.753398348762388e-07 / 0.00028733812150622895 / 0.0007167010349785833 / 2.307106816252697e-05 / 5.337901424957087e-05 / 0.020106125155811467 1.3332679478124245e-07 / 1.1868875335385447e-05 / 2.7070790605645726e-06 / 7.056569159589176e-06 / 0.0002157049138716117 / 4.445857267298034e-06 / 3.642358929245767e-05 / 2.406762142831913e-06 0.002694 8
17 SMPD1_1 0.0000009495 0.003065043011644369 / 0.0023157697041580965 / 0.0012909968347916095 / 0.0006256240573576323 / 0.007223252257555813 / 0.03771188975485943 / 0.0003890294490866307 / 0.00736333395639105 5.955099761237206e-13 / 3.051847715980306e-09 / 1.8525537737343062e-08 / 6.490954203776185e-06 / 9.743943487605562e-08 / 1.3599979831920288e-06 / 8.962608566425138e-06 / 5.6013193436695554e-06 0.007498 8
18 PEA15_5 0.0000000000 0.0002596888575908078 / 0.0013300138356594274 / 0.00524721075079139 / 0.006442952776112118 / 0.018912868681800837 / 0.01937026642721713 / 0.01438287077969559 / 0.0004932314709699339 4.44845454863038e-09 / 1.0130302320647733e-07 / 4.515074038541242e-07 / 2.962208123523371e-06 / 1.8659873824466947e-06 / 2.323546008318182e-06 / 2.7318856566845997e-06 / 1.1792288071015321e-05 0.008305 8
19 SLC25A43_1 0.0000001166 0.0012903447119515423 / 0.004158933151515996 / 0.008351774878422811 / 0.04843122350083363 / 2.540557327027098e-05 / 0.0003105144729205529 / 0.010869042090733612 / 0.02588573867516253 1.891414179412052e-09 / 2.1049137124860745e-07 / 5.230089820717235e-09 / 8.635969388699494e-07 / 5.5411681205887995e-08 / 7.317272575393834e-07 / 4.148735135683505e-07 / 3.228573281191034e-05 0.012415 8
20 MT2A_5 0.0000000000 0.00011447752236282417 / 0.0002544633476725284 / 0.00017859214428829218 / 0.0005165077368872941 / 0.00014503469256866046 / 0.000601999882354011 / 9.573116134444548e-05 1.584500848087154e-07 / 2.51478016245715e-07 / 8.54720361712193e-07 / 6.516915144267419e-06 / 5.171536692079251e-06 / 8.802100259189991e-06 / 1.6314636428146748e-06 0.000272 7
21 RUNX1_2 0.0000000000 0.0005559642828812122 / 0.0008971360026655244 / 0.0009701318251119559 / 1.7922091488637388e-05 / 0.00017935064903782676 / 0.0025863116474804755 / 0.0001657906685047857 1.9576595780585085e-10 / 2.1776070811919277e-07 / 7.527037299722958e-07 / 2.559009185958782e-07 / 2.2176040120466972e-05 / 2.5598942326458564e-06 / 8.17316116112682e-06 0.000768 7
22 LRRC8B_3 0.0000000000 9.4941920370122e-06 / 0.0015781807884715357 / 0.0002622885842506721 / 0.0011548969209222207 / 0.005697781111749079 / 7.700053244511214e-06 / 0.001483718198167863 4.296394955066174e-08 / 1.4324682153058617e-05 / 1.7104030080984345e-05 / 7.565682931060495e-07 / 1.624606018039645e-05 / 4.1115916939474605e-06 / 5.004433338367946e-06 0.001456 7
23 PSMB9_4 0.0000000000 1.1255116843939685e-06 / 7.444306538180959e-05 / 8.121302745530734e-05 / 0.006696643814464557 / 0.0001492527064854631 / 4.25829047419839e-06 / 0.003283436953926786 5.9405281136078796e-08 / 4.799096156918887e-07 / 6.170625684612102e-06 / 1.4805988081664244e-06 / 1.6676304471263215e-05 / 2.337476084860884e-05 / 2.138799423764577e-05 0.00147 7
24 RRAS_5 0.0000000000 8.182509603383713e-07 / 0.00021369162894747652 / 0.003190351183802246 / 0.00679937164887004 / 9.99040056201094e-06 / 0.002342765582078353 / 0.00018160002648956962 2.876707427462528e-08 / 6.680110293230449e-07 / 5.972855062819303e-07 / 2.8451937899285467e-05 / 7.687368595573398e-06 / 7.477786594755585e-07 / 1.3224569563917872e-06 0.00182 7
25 TMBIM1_5 0.0000000000 2.322967022611346e-06 / 4.188818420450373e-05 / 8.859519927799691e-07 / 6.20461992462773e-05 / 0.00026413620242118544 / 0.00014398625006041495 / 0.014948105524536974 9.353599152353929e-08 / 5.844591678215266e-07 / 1.5978510581326625e-07 / 9.291490547025219e-07 / 2.7475634725757366e-07 / 4.753956509088212e-05 / 9.311198865860414e-07 0.002209 7
26 KLHL23_3 0.0000000004 0.00012805365107500054 / 0.002519598458842781 / 0.0004515536091125032 / 0.00022680614492479574 / 0.009733620762754698 / 0.0042912100983332774 / 4.9219858574682586e-05 9.921726897145688e-09 / 8.717866079599918e-06 / 8.841783359385233e-07 / 1.1383657613478495e-06 / 0.0008824236923248849 / 3.398353518910182e-05 / 5.795994893765768e-07 0.002486 7
27 EWSR1_1 0.0000005663 2.098169823270148e-06 / 0.00920357999307954 / 1.7711409436331332e-05 / 0.0014863302195178008 / 0.0014863302195178008 / 0.005409509534570436 / 1.9786173221795818e-05 4.043867582082559e-07 / 8.844612889243844e-05 / 2.099411528051961e-06 / 6.37244282155154e-05 / 3.479676125457968e-06 / 4.563731385373264e-06 / 8.51275649150399e-06 0.002518 7
28 ZNF124_3 0.0000000174 0.01185115455025083 / 0.0028820143512348784 / 0.0006400036981941583 / 0.00022237327343913756 / 0.0017326407356747695 / 0.0002237032245520265 / 0.0002896824687842766 3.830190864530467e-08 / 0.0005023437846254026 / 1.4341269466072291e-05 / 1.9187040433353085e-05 / 3.0536343957588886e-05 / 0.00015912558081257976 / 0.00030057122653906633 0.002549 7
29 CAPG_2 0.0000000000 0.00016360654996415964 / 0.003107700700013517 / 0.004526868535758527 / 0.003825441026009639 / 0.00040288084200566923 / 3.2262553686676067e-08 / 0.006275421665752097 1.6061695068770962e-09 / 6.708972026453563e-07 / 6.9252484921311626e-06 / 8.27034474165013e-06 / 9.342485200961395e-05 / 8.711780875641735e-07 / 5.302432363858073e-06 0.002615 7
30 TGOLN2_2 0.0000000030 0.0002870649623628604 / 0.005727463389908907 / 1.203780953398585e-06 / 0.00027661203249205183 / 0.0005689555709178733 / 0.0006501827815986053 / 0.014330254737635668 3.619262458649237e-11 / 4.769486326622182e-08 / 1.6622051928852046e-08 / 3.6038229751219804e-07 / 4.940074588134348e-05 / 1.8592574634706461e-06 / 7.392344957282081e-05 0.00312 7
31 RBFOX1_1 0.0000008465 0.0006456808009902826 / 0.0009805618383529596 / 0.0005802206884848052 / 0.0007177403550416762 / 0.00731321321837694 / 0.0011231690936696782 / 0.010617152378270862 2.2848739279053027e-11 / 3.403410943591806e-08 / 5.3253671669888775e-06 / 5.391441835390658e-06 / 9.82032865139159e-07 / 4.249582206860703e-06 / 4.042294162166094e-06 0.00314 7
32 RANBP2_2 0.0000000020 0.0032005645957622507 / 1.1292974727160135e-05 / 0.004582586266801288 / 0.005968942599275744 / 0.0007669246686613953 / 0.0003836018962680972 / 0.01256992621275457 1.0278781040318966e-06 / 3.2181914215686755e-07 / 9.03950843772086e-07 / 2.2352937628807305e-06 / 1.2237851910310582e-05 / 2.3260388622347645e-06 / 3.157729990156927e-05 0.003926 7
33 CCT2_1 0.0000000610 0.00037839447623271325 / 0.00042879723237597764 / 0.001443320215490813 / 0.00028286232014178015 / 0.008201744521300066 / 0.002944369153927747 / 0.01649068093735444 1.2749486030115433e-08 / 1.1225851282580173e-07 / 6.873884305086476e-09 / 2.2752402825301866e-07 / 1.0015662188091184e-06 / 3.453963505596524e-06 / 5.058184693460015e-06 0.00431 7
34 CEP95_2 0.0000000004 0.0007190070321581675 / 0.0002545171218429651 / 0.0035966015072663835 / 0.0025521170193974763 / 0.0003107381669592285 / 0.027502917617089746 / 0.0012110736028058307 1.3949676285490207e-07 / 2.1170919481613956e-08 / 2.8596627227079915e-05 / 9.032373803983716e-08 / 4.00753265620622e-06 / 6.457362557632581e-06 / 4.791358118111102e-07 0.005164 7
35 GINM1_3 0.0000000000 2.8556636750809756e-05 / 0.00012092027077076626 / 0.004350456289105647 / 0.0028744599511057625 / 0.009781859661254071 / 0.012315629622740824 / 0.014183888091677869 3.741940140138828e-09 / 6.30551384179601e-07 / 5.723523849148954e-07 / 4.137409181237638e-07 / 4.058957920972812e-06 / 1.324094056480911e-05 / 5.334206696833551e-06 0.006237 7
36 POLG2_2 0.0000000067 0.0002576770516093337 / 0.0016833422652258513 / 0.01537032415812942 / 0.0199546774517756 / 0.011879693396648705 / 0.013778504455704959 / 0.0006073423559504219 8.002612553216828e-12 / 2.5154718511604325e-07 / 5.542657615241579e-07 / 6.569612124521097e-06 / 5.133965042123324e-06 / 4.188709032414043e-08 / 6.35362381394998e-07 0.009076 7
37 RAN_2 0.0000000007 8.10356681117687e-05 / 0.0015745833133913741 / 0.0003323999875867436 / 0.014323464285551478 / 0.003484183595989438 / 0.0003293358901815535 / 0.045671136243731716 4.467053904818645e-09 / 8.90912425766829e-06 / 2.7276695958874614e-07 / 1.6612137127547922e-06 / 4.295327136339735e-06 / 0.00010945540484186873 / 0.0007487722885105004 0.009399 7
38 MTF2_2 0.0000000001 0.00024102538797346086 / 0.001539940029122352 / 0.005818462625160796 / 0.04331587497952318 / 0.003473006180561586 / 0.013123198329328149 / 0.0011086944827796786 5.524058788809012e-07 / 2.255174371885246e-07 / 1.0230509628865922e-08 / 1.5272339234163363e-06 / 4.502242650312079e-06 / 1.4470801258175914e-06 / 4.0947329724111495e-06 0.009803 7
39 CMPK1_1 0.0000099465 0.01615823448153983 / 0.03373282648472924 / 0.016556829420777325 / 0.01344459083967992 / 0.0011586570434241133 / 0.007942503974326632 / 0.006386843886902124 2.364261967442666e-08 / 5.989349364171967e-07 / 1.051890467879646e-07 / 2.8069595654757565e-06 / 2.675202019953556e-06 / 4.952772665629785e-06 / 8.5101324606656e-06 0.013626 7
40 MDN1_1 0.0000149331 0.027136920905959004 / 0.015382714940475899 / 0.0002021790532799894 / 0.025082579510674555 / 0.002667939855033078 / 0.01903033340546255 / 0.023433853775319136 3.1384912120068307e-10 / 9.325247533918398e-06 / 6.936897377329882e-07 / 2.353698101267621e-06 / 1.4783005405825795e-05 / 1.3845703258818903e-06 / 3.794277797288223e-07 0.016134 7
41 INPP1_2 0.0000000458 0.00012405403034171616 / 1.718785742696879e-05 / 6.396622257100077e-06 / 6.925570695765487e-06 / 3.9200560425745034e-05 / 1.2385564215356241e-06 5.3962567655992866e-05 / 8.480907105422951e-07 / 2.8149687924382837e-07 / 6.886821060328188e-06 / 4.946024817438151e-06 / 2.5531357893982e-06 3.25E-05 6
42 TOMM20_5 0.0000000000 9.847481167714172e-07 / 5.461787394016582e-07 / 2.630785074908594e-05 / 6.807575706103957e-07 / 6.31788143549132e-07 / 0.0002787072964560934 1.828485836400758e-09 / 8.488593461887543e-08 / 4.561158256034957e-06 / 1.357508261446604e-07 / 2.9348649605847958e-06 / 1.3733983916997187e-05 5.13E-05 6
43 S100A6_3 0.0000000000 3.987563090636182e-09 / 6.751332523310354e-08 / 5.131148780828573e-06 / 5.346137072472972e-07 / 0.0008192357956865613 / 1.657842655825674e-06 1.8859563430955987e-09 / 1.5597048970633669e-07 / 6.731790637644895e-07 / 3.923562825747655e-06 / 7.57844698984901e-05 / 1.7516083103081196e-06 0.000138 6
44 ZNF74_5 0.0000000000 7.220170669604226e-07 / 0.000560135938998767 / 3.1675474781598684e-05 / 0.0005276313183088553 / 2.1660265856759415e-06 / 0.00015601716830048032 1.4629848729112387e-07 / 1.1761012404538385e-06 / 4.011024961679582e-05 / 2.0573826720469716e-06 / 2.0056325015251253e-05 / 3.125081554604303e-05 0.000213 6
45 ZNF195_3 0.0000000000 4.2041150573934295e-05 / 4.5529669866602804e-05 / 0.0007203033990971563 / 0.00014468246920967197 / 0.00031951653993607604 / 8.595632585615447e-05 6.719675625838534e-09 / 3.8056480729458196e-09 / 7.723330075061024e-07 / 3.1795531703660226e-06 / 4.735362185795e-06 / 1.0975067398076295e-06 0.000226 6
46 DNMT3A_2 0.0000000000 6.115665040218944e-06 / 3.206324028832219e-05 / 8.429951747175733e-05 / 0.00019962122279230926 / 5.615553156462022e-07 / 0.0021806139002983004 1.511429559536217e-08 / 3.3834848660671585e-06 / 1.0925063596049997e-07 / 6.95434985454603e-08 / 4.9915249752075324e-06 / 2.7418564056278035e-05 0.000417 6
47 PXDC1_3 0.0000000000 0.00018564783748412937 / 0.0006324544157642112 / 0.0008799932868837088 / 0.0012100854406902743 / 2.4460595957570077e-05 / 9.238919654315156e-05 1.629093796438785e-09 / 2.354828010860969e-08 / 1.1437120990282457e-06 / 2.506826726053496e-07 / 1.4404482300034928e-05 / 1.341496646230468e-07 0.000504 6
48 HOXD8_1 0.0000011390 1.384655004104117e-06 / 2.098169823270148e-06 / 0.00013057839781136293 / 0.0006273187563236247 / 0.002391299161389133 / 0.00012418009082273935 4.462177612672371e-06 / 3.7108705034506107e-07 / 2.588422064155111e-06 / 4.951039991487746e-05 / 1.3325001401014987e-05 / 0.00014465241485038646 0.000546 6
49 CREB3_5 0.0000000000 0.00011974638832910611 / 2.8492275991361182e-06 / 0.0002672299360603039 / 0.0015619495448511997 / 0.0006694225755824582 / 0.0007820104355851261 3.367539235619778e-08 / 2.960146168251713e-09 / 3.5507108068252503e-07 / 1.15634806074712e-07 / 9.547786692388759e-08 / 9.283068268133278e-07 0.000567 6
50 HDAC2_5 0.0000000000 0.0024571245521046946 / 0.00027132067925628834 / 9.682089638458799e-05 / 0.0005745209404259057 / 0.0011143521019561335 / 8.813885171995659e-06 5.2270805905618696e-06 / 5.052158985938859e-07 / 2.8819687490380823e-06 / 2.0125230234433194e-05 / 2.0453412309359413e-06 / 2.7524824404052385e-05 0.000754 6
51 TIMP1_5 0.0000000010 0.0007131856153707479 / 0.004395200198238863 / 0.0007246067046570448 / 0.0004898581392129352 / 0.0005314272666539294 / 0.0011397228331407 5.172684196778569e-07 / 2.311501161730639e-05 / 3.21307883800088e-06 / 6.009010264662183e-07 / 8.327439275864646e-05 / 1.1941646912994778e-05 0.001332 6
52 COQ10B_2 0.0000000036 0.00028381156148520563 / 0.0011945192630844516 / 9.355412559125023e-05 / 0.00011447010352733596 / 0.004266156536665072 / 0.006336011637689165 9.039504276825803e-09 / 6.006195461219958e-11 / 1.974259905174528e-07 / 1.2053082748861081e-06 / 5.363487408950924e-07 / 6.630188454539638e-06 0.002048 6
53 REEP5_3 0.0000000001 0.0002604645915174344 / 1.6662214108439007e-05 / 0.0014440576489070092 / 0.007046402501490371 / 0.0001422863963685906 / 0.003637547802268041 1.5498910474749387e-08 / 1.5248778277061658e-07 / 4.842659456067433e-07 / 1.1491084964019146e-05 / 9.94537200846768e-06 / 1.9463332862931604e-06 0.002091 6
54 FAM111A_5 0.0000000000 4.4898969618553406e-05 / 2.4668455632971913e-06 / 0.008396935784803085 / 2.1285938805234283e-05 / 0.00017201334171284462 / 0.00396513630435739 2.8379627983912504e-07 / 5.011442931035688e-06 / 2.7338260851547263e-06 / 8.36960570585275e-07 / 0.0001410578503689771 / 0.00014811827476060585 0.0021 6
55 XPO5_2 0.0000000001 0.0001209623595819047 / 0.000188340547489593 / 0.0018652619870494437 / 0.00021645065939681314 / 0.003380556290063177 / 0.008610130886641778 3.868080212014016e-11 / 9.213293248318617e-08 / 1.7999848646465621e-06 / 2.4843669693960186e-06 / 4.8157427373392145e-06 / 1.6123249086459064e-06 0.002397 6
56 MICALL2_2 0.0000000015 0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 / 1.9308695609987287e-05 / 0.00038134035343875063 / 0.012364148039779468 7.498455684868167e-10 / 1.4582924103607157e-08 / 1.3913032862815633e-07 / 5.643046267928915e-06 / 9.075353821264667e-07 / 6.490175971759533e-07 0.00274 6
57 ITGA3_1 0.0000000030 0.005770181686062503 / 1.2412020538304333e-05 / 0.0014786332863597391 / 0.0025299472548494955 / 0.006820424547488444 / 0.0005531418384342248 5.922775528802422e-07 / 4.6735775256735116e-07 / 1.1163600156129396e-05 / 1.4439518922300546e-05 / 2.1428615198188343e-05 / 0.0004769133582838131 0.002861 6
58 MATR3_5 0.0000000205 0.011926215274063212 / 0.0009331303043566046 / 0.0010276150171031416 / 0.00182336903581431 / 0.0003580914875982602 / 0.0015078412320002777 4.924418504897322e-07 / 1.370559303361593e-06 / 1.6001662179812555e-07 / 1.1659751397403969e-06 / 3.3107751763197302e-06 / 0.00023808544096258719 0.002929 6
59 SAT1_1 0.0000002126 0.00037839447623271325 / 0.00010681753824403367 / 0.001443320215490813 / 0.00028286232014178015 / 0.00042879723237597764 / 0.01649068093735444 2.471908559304084e-08 / 1.0167276826134301e-07 / 4.27349479221232e-08 / 1.9148903772583427e-06 / 5.811635331171456e-06 / 2.062293334552713e-06 0.003188 6
60 TMED9_2 0.0000000049 0.004580742781866771 / 0.00013157696997892983 / 0.004688381529867688 / 0.009588847065017484 / 0.002359920632447335 / 2.045294378465323e-05 2.311738097680596e-07 / 3.385203606751943e-07 / 1.428134704742174e-06 / 2.2508154783841546e-06 / 8.005735739477652e-07 / 5.167281077719583e-06 0.003562 6
61 KIF26A_2 0.0000000001 1.5469524150486244e-06 / 8.296463018176517e-06 / 0.006895380226562706 / 0.012900561921483814 / 0.0032271260560706324 / 0.00021924462904813837 1.5344327905473364e-07 / 2.061988698426251e-05 / 8.65696212540371e-05 / 0.00020969562979674127 / 2.9068598486233544e-05 / 7.962530247357052e-05 0.003875 6
62 C19orf66_2 0.0000000010 0.00034498616340953534 / 0.011682032301995177 / 0.00022585824160449916 / 0.0007089738037200934 / 0.002717071783164195 / 0.0083826665816656 1.6212467312990448e-07 / 8.055304607431e-07 / 2.1285718913705297e-05 / 6.7336653328809105e-06 / 9.184791210195023e-06 / 5.963654428661317e-05 0.00401 6
63 GTF3C2_2 0.0000000532 1.1143488565728274e-05 / 6.351892014238265e-06 / 0.00014033845457246834 / 0.0056660681635887335 / 0.018064176445119352 / 0.001679572583230773 5.3778331923390924e-09 / 3.451157087485289e-08 / 1.036058010685455e-05 / 6.86847495002417e-07 / 2.1756858153773495e-05 / 1.4832082275306326e-07 0.004261 6
64 ADAM9_5 0.0000000000 9.192181643816992e-05 / 0.01456393928510654 / 0.0024406101382475976 / 0.0003651548756090639 / 0.002859171921278692 / 0.005910547863522942 1.2444797620355103e-06 / 0.0006441060918252728 / 6.0935458892623245e-06 / 2.470519395812343e-05 / 6.138314516641965e-06 / 0.00047208959650121314 0.004372 6
65 KDM1A_3 0.0000000105 0.00020172074167490282 / 6.059446073630997e-06 / 3.4966947244211546e-05 / 0.00035787841907612255 / 8.084536486163457e-05 / 0.030001525763098943 1.9191726349291212e-07 / 1.1031846529359998e-09 / 1.1293378746596968e-07 / 3.850331218970383e-06 / 3.0967264542843456e-07 / 4.878540657681566e-06 0.005114 6
66 SRSF1_1 0.0000149516 0.003065043011644369 / 0.00022847309395920425 / 0.007223252257555813 / 0.002399019537670231 / 0.0023157697041580965 / 0.016498427519842422 1.756253200088118e-08 / 1.4552116534728694e-07 / 1.9822115797618054e-07 / 0.00022932374573720484 / 8.206690733883024e-07 / 2.2543227834379112e-07 0.005288 6
67 WHAMM_1 0.0000006802 0.00173044075017522 / 3.679473658399758e-05 / 0.007154235078360664 / 0.0005658979552839525 / 0.022166841169996183 / 0.0008973831238703076 1.819882893948959e-08 / 7.796445160214981e-06 / 4.241150850168489e-05 / 2.1522400443486433e-05 / 1.3244633411180583e-06 / 3.4248686087626584e-06 0.005425 6
68 LEPRE1_4 0.0000000000 0.0009439710790866046 / 0.0005817669851518343 / 0.001866551132439743 / 0.0064518824694126935 / 0.024010305513094434 / 0.0005799813920946167 5.057896230784973e-09 / 1.2435409883337575e-09 / 4.849591006599988e-07 / 2.513207633152382e-07 / 7.926212421845088e-06 / 9.994009471711418e-06 0.005739 6
69 TRMT61B_1 0.0000029142 0.00019565429421873628 / 9.250262180987785e-07 / 6.358888418896258e-05 / 0.007843131253822322 / 0.026473307528210963 / 0.0005756579425604447 1.5078060373014486e-07 / 2.934542273575563e-07 / 1.2562708953802216e-08 / 5.523864073902343e-05 / 2.1559815321332083e-05 / 3.99120679034904e-07 0.005859 6
70 KANK1_1 0.0000005033 0.00029139375190295606 / 0.009220967328515883 / 0.008770410107355643 / 0.014437131210731376 / 0.002271551295087959 / 0.004557941079021841 5.395125257906878e-09 / 1.5463446946793206e-07 / 9.30211963759247e-07 / 1.5254780926528496e-05 / 2.370997764208311e-05 / 3.6188491330904777e-06 0.006592 6
71 FAM126A_1 0.0000010549 8.712601577854501e-09 / 4.778480179883678e-05 / 0.029987683740818265 / 0.0006110060061203364 / 0.0014562282237067896 / 0.010748894710017389 5.924782315476787e-13 / 7.1855057793508855e-09 / 5.8414503343797016e-08 / 3.0767728402054146e-07 / 3.866278498641532e-05 / 6.044718602493066e-06 0.007142 6
72 CASKIN1_1 0.0000009531 0.0004052971561229435 / 0.004531342266561176 / 0.0026490796375761676 / 0.0030838618137353662 / 0.0016555906467057811 / 0.03955358967054088 6.0724511656641e-08 / 2.4239072038012358e-06 / 2.9932584561794108e-06 / 2.381049500017635e-07 / 3.5273148222341567e-07 / 8.97249895656115e-07 0.008646 6
73 PHIP_3 0.0000000007 0.00021593310745224813 / 0.001021373946566871 / 0.000875589310570064 / 0.03219163721249994 / 0.018101605571703944 / 0.0018008865475031112 7.804787711336222e-10 / 7.962047079615459e-07 / 1.3767715926221406e-06 / 9.21068648623731e-07 / 2.0427438064371946e-06 / 2.061133383896347e-06 0.009035 6
74 ISL1_1 0.0000011109 0.00029139375190295606 / 0.004557941079021841 / 7.763485144629643e-05 / 0.03147989324458417 / 0.009220967328515883 / 0.014437131210731376 1.0776705684350702e-07 / 9.139106854866213e-08 / 1.5262551782073314e-06 / 7.17589463363722e-05 / 1.6643398808959587e-05 / 2.7254012211130744e-05 0.010011 6
75 FAM114A1_1 0.0000011740 0.008158453075892491 / 0.00706078944078839 / 6.392429369799613e-05 / 0.047093499348454915 / 0.0011036487237694873 / 0.0012146763275784356 3.9222069331739446e-09 / 1.0484859600093688e-07 / 1.1328590320930398e-08 / 1.4044847451826967e-07 / 1.6732185403869882e-06 / 2.0603621902808526e-07 0.010782 6
76 BHLHE40_5 0.0000000001 0.0007215354754391255 / 0.0003445000837785309 / 1.9977845432945953e-05 / 0.04162183582083479 / 0.0018003544554504962 / 0.022135056393026143 1.9299792697031883e-08 / 5.991364646156074e-06 / 6.2842442407564126e-06 / 7.23523138723521e-05 / 4.37410397098931e-05 / 8.612084128833267e-05 0.011107 6
77 RNH1_2 0.0000001050 0.000506059688566897 / 0.005186853257558283 / 0.012649170673498711 / 0.001227543851685287 / 0.02830343719752466 / 0.04658173961213423 1.9114165577673726e-07 / 1.1785627242528596e-05 / 1.1961430183679334e-05 / 5.5941363386033185e-06 / 0.0003160168984552755 / 6.436245153753663e-06 0.015742 6
78 SLC35F5_2 0.0000000018 0.0004361351075887015 / 0.022927539814265496 / 0.04092933544326924 / 0.006547044668673556 / 0.028271710657491178 / 0.00020952110146219778 4.764738756551879e-09 / 4.080828723669075e-06 / 3.470949128294469e-05 / 1.4915989057385644e-06 / 3.6434591065850956e-07 / 5.290028218404434e-06 0.016554 6
79 TRAP1_1 0.0000001560 0.0020456136275657888 / 0.002859168680149655 / 0.005851685675009941 / 0.01576374271095223 / 0.026715472976530045 / 0.04871212229027521 3.490113886399775e-11 / 1.4427864532484367e-07 / 6.218256736106799e-06 / 8.405023850544253e-07 / 1.4752725092614505e-05 / 0.000126359581600695 0.016991 6
80 SLC10A3_1 0.0000020963 0.011413935706631708 / 0.017443397981769932 / 0.014660785392642973 / 0.017145541610166553 / 0.03683753470884825 / 0.010610163045225487 5.700211166503259e-07 / 1.392805628701067e-07 / 3.319072411206087e-06 / 4.021260874574252e-06 / 1.6786320992493728e-06 / 6.426344116619477e-06 0.018019 6
81 IL10RB_1 0.0000014439 0.0018473350729729212 / 0.025082579510674555 / 0.015382714940475899 / 0.01903033340546255 / 0.042397669225769964 / 0.010590633670572098 6.305508475517821e-07 / 2.1289852323575975e-06 / 1.3929853301059418e-05 / 5.9674182467591734e-05 / 0.0005196865649666491 / 8.689281900910874e-05 0.019055 6
82 CCDC138_3 0.0000000000 2.8507575756692187e-05 / 8.39983457440053e-08 / 5.171191093952371e-06 / 0.00013241015291548088 / 0.00013231289428074683 3.594844984072266e-08 / 4.1699450769671714e-10 / 1.7829184957785041e-06 / 1.6716512185751531e-07 / 6.673606916636778e-06 5.97E-05 5
83 LDLRAP1_1 0.0000008179 0.00011095297992729127 / 5.264359468000088e-05 / 0.0011242387519002353 / 4.668223816223458e-05 / 1.2920956774321015e-06 7.024419920758419e-08 / 3.7947570137300835e-07 / 1.3563326532912054e-07 / 8.17408329321785e-05 / 8.828337775002166e-05 0.000267 5
84 SH3BGRL3_3 0.0000000001 4.2473135511991315e-05 / 0.00018110968427817472 / 2.3012675922598175e-05 / 0.0012229341595829208 / 7.876891018158643e-05 6.991877310539878e-06 / 9.480200177754412e-06 / 0.00015579668074547338 / 1.8811555342370173e-05 / 6.910060016993254e-06 0.00031 5
85 RARRES3_3 0.0000000000 5.445858436353469e-05 / 0.0009962374983153238 / 0.00039011483425120365 / 0.00012136000976514409 / 3.791878524439541e-05 1.56194833594799e-09 / 1.296245999203945e-06 / 1.1756173797034747e-06 / 1.527843952821709e-05 / 5.848148683004699e-07 0.00032 5
86 ANXA4_4 0.0000000000 1.363288691355937e-06 / 1.5143046244596162e-05 / 5.189840282140393e-05 / 5.782599824929034e-05 / 0.001524236220832947 1.0031685363992852e-08 / 6.841456697948725e-09 / 1.9180526546377784e-06 / 8.794172382219916e-06 / 2.953468988272718e-06 0.00033 5
87 LYST_1 0.0000027714 0.0014431024451110606 / 5.264359468000088e-05 / 0.00011095297992729127 / 0.00020173841888508878 / 6.995348463708383e-05 1.1240472731245707e-08 / 2.350080008352624e-06 / 1.1075551169706485e-06 / 1.7042664405713885e-06 / 4.2116046384684526e-05 0.000376 5
88 MR1_4 0.0000000000 7.715095979792449e-07 / 0.001693666645875025 / 6.395023692800854e-05 / 0.00031256159798863684 / 3.9188876899229826e-06 1.1557582761220409e-08 / 5.677180579700876e-06 / 2.8754646285556484e-06 / 5.64979021764616e-07 / 1.8797358227572578e-05 0.000415 5
89 SELRC1_1 0.0000005524 0.00037839447623271325 / 0.00042879723237597764 / 0.001443320215490813 / 0.0004410378323337517 / 0.00010681753824403367 1.2864802377615588e-11 / 2.1196501777135548e-08 / 1.3367474421932726e-09 / 7.5658631683473564e-06 / 5.602327158926525e-08 0.00056 5
90 LDHB_5 0.0000000000 2.9413591946334052e-06 / 0.00018071660821354673 / 1.726070100137361e-05 / 0.0006331647449173639 / 0.0029940534519961185 2.3674403554451728e-09 / 1.5213269839159292e-06 / 4.075392395353731e-07 / 1.8533263086532664e-06 / 6.582873587671421e-05 0.000766 5
91 GBE1_2 0.0000000003 0.0033273695719493366 / 2.1541055929197527e-08 / 1.9308695609987287e-05 / 0.0003451393798156882 / 0.00038134035343875063 5.906459505383357e-08 / 2.4094693488118412e-09 / 1.0620489017054289e-07 / 6.750639833651121e-07 / 1.8752484455808676e-05 0.000815 5
92 PTRF_2 0.0000000003 0.0033273695719493366 / 2.1541055929197527e-08 / 0.0003451393798156882 / 1.9308695609987287e-05 / 0.00038134035343875063 4.017261878814523e-08 / 7.146428295045248e-09 / 6.101976957550238e-07 / 2.1688184575439267e-06 / 6.686443921029525e-06 0.000815 5
93 SQSTM1_3 0.0000000000 3.9761649107081705e-05 / 0.0016006026930324019 / 0.0008611052684263142 / 0.0012009850065108874 / 0.0006237640708459632 4.01947151989452e-07 / 1.339226375307952e-06 / 1.754090841474079e-06 / 7.055430531026282e-07 / 2.6767693410519625e-06 0.000865 5
94 PA2G4_1 0.0000000017 0.001443320215490813 / 0.00037839447623271325 / 0.00042879723237597764 / 0.003993715376548959 / 0.00028286232014178015 3.045245115555592e-10 / 1.8399976601880802e-08 / 5.830030485334704e-07 / 9.508100999171547e-06 / 1.13769352855429e-05 0.001305 5
95 GBP3_2 0.0000000003 0.0005839379621670203 / 1.3428726435262393e-05 / 0.005991852836482861 / 0.0001081781120537704 / 2.8744610334651343e-06 4.819954330621288e-08 / 6.412523041836917e-07 / 2.8569657952677404e-06 / 2.0985004888144685e-05 / 2.3525509311119436e-06 0.00134 5
96 CHD7_2 0.0000000001 0.0018350968591216627 / 7.477363698097769e-05 / 0.00015975427450238799 / 0.00391277170211791 / 0.0008685464813169234 1.0531573829941702e-07 / 7.878415280920932e-08 / 1.1141611641319887e-07 / 5.1757956178869716e-06 / 8.934190321293886e-06 0.00137 5
97 ELF4_4 0.0000000000 1.5042859087051511e-05 / 0.0015054443180049152 / 0.0035324162802343384 / 0.0015681053781698034 / 0.00044306616234558656 1.0129117193066866e-07 / 3.803422404924242e-08 / 3.196969576173562e-05 / 2.0994506448972058e-06 / 8.674339153748824e-06 0.001413 5
98 HEXB_2 0.0000000027 0.0001364689621921479 / 0.0017139782149577006 / 0.00042251637580553855 / 0.004506824346577342 / 0.0011693468213267385 5.600402893224147e-07 / 1.7114753018966675e-06 / 7.859127616630422e-06 / 2.136847848300081e-06 / 1.057919545610576e-06 0.00159 5
99 TGOLN2_3 0.0000000000 0.002887936541355392 / 0.0012489133459296009 / 3.971802768150102e-09 / 5.351370414635355e-06 / 0.004542992850202789 1.5278667902264538e-08 / 6.147579495364705e-07 / 2.55317658003628e-07 / 9.866879372887889e-08 / 6.124699763744859e-06 0.001737 5
100 CBR3_5 0.0000000000 1.7429615872247697e-06 / 2.1772701241259695e-05 / 4.265116466854638e-05 / 0.0006691661140725223 / 0.009174735989250154 1.7321244665799745e-08 / 1.9865066542844766e-06 / 6.139861852092745e-07 / 3.5205839483278234e-06 / 4.046680434424515e-05 0.001982 5
101 C14orf93_1 0.0000000417 0.005409509534570436 / 0.0014863302195178008 / 0.002391299161389133 / 0.0006273187563236247 / 1.384655004104117e-06 7.500915749450172e-10 / 3.167346841801568e-06 / 6.173059623938025e-07 / 7.496583765477882e-06 / 2.018269137344719e-06 0.001983 5
102 ACVR1B_5 0.0000000000 0.0011897273750790794 / 4.043863569216427e-06 / 0.003135726107000613 / 1.2302005748125012e-06 / 0.005979891210353361 8.795727468366677e-07 / 1.740359378085258e-08 / 3.922859794878605e-06 / 5.715287595383605e-07 / 3.0426357547305182e-05 0.002062 5
103 WNK2_1 0.0000008965 0.004531342266561176 / 0.0004052971561229435 / 0.0026490796375761676 / 0.0016555906467057811 / 0.0030838618137353662 5.735186182795572e-07 / 4.097215580173646e-09 / 2.1966688549867895e-05 / 7.38514634627583e-06 / 9.495710202696889e-06 0.002465 5
104 GBE1_5 0.0000000000 3.826852437313171e-06 / 0.0010708658291423757 / 0.00019953068534511048 / 0.009169711616283972 / 0.0026316110463780696 9.044891469948086e-09 / 3.7048735780400227e-07 / 2.359441941877069e-06 / 1.5764817932193767e-05 / 2.274686348690355e-05 0.002615 5
105 RAB27A_2 0.0000000000 7.635253341668868e-05 / 0.005021656852415849 / 3.5215907075366917e-06 / 0.00034267788827357215 / 0.007895113233237851 1.914896020510999e-07 / 9.517291296985127e-08 / 7.969576900636687e-08 / 5.846288233066031e-08 / 4.5361993939378207e-07 0.002668 5
106 FAP_3 0.0000000006 0.0019684942173753836 / 0.0009928703588443979 / 0.0005051149609558843 / 0.00011232928113623314 / 0.012918030852908461 1.2766883170125572e-07 / 2.4021041707717316e-06 / 1.0836840144491595e-06 / 8.446479999419288e-06 / 3.6833375749558764e-06 0.003299 5
107 THBS1_1 0.0000000712 0.0019027179320774803 / 0.004613449756294485 / 0.0003168019030192227 / 0.0012733956455115425 / 0.010654255097368902 2.1096989696063183e-09 / 2.8418823932552776e-08 / 2.9577603926263325e-08 / 1.6345742810026593e-05 / 7.1941049967859985e-06 0.003752 5
108 RNF44_2 0.0000000001 0.0007973635551597535 / 7.563774009011881e-05 / 0.01008336409450162 / 0.004045539400699223 / 0.004865413756574913 5.271414210724663e-11 / 3.736942531550046e-07 / 2.3747819656119838e-08 / 1.893540361128054e-06 / 1.2212684566221971e-06 0.003973 5
109 C2orf44_4 0.0000000014 1.0808929306666273e-05 / 0.008934208121620274 / 0.00010039306136116464 / 0.009784265308543377 / 0.0024009587334497774 1.2187744602716387e-10 / 1.9588399373708684e-06 / 4.6145010226590306e-07 / 3.855402108931244e-05 / 2.3663313142656787e-05 0.004246 5
110 ZSCAN2_1 0.0000003244 0.005494404451518434 / 0.002117501407135496 / 0.015063580358728427 / 0.00406276527468287 / 0.00029389877591584477 4.440150276665828e-06 / 1.6041254678652375e-05 / 6.101223267687242e-06 / 1.4917171986665666e-06 / 1.8918665259353665e-05 0.005406 5
111 PSMB8_3 0.0000000001 1.1139371348435439e-05 / 0.000295206951604009 / 0.0011420234721703612 / 0.004002189263586216 / 0.022007285373854 3.18097586113718e-08 / 8.739864511743991e-07 / 1.4187996767508308e-05 / 1.4206186275488269e-05 / 2.1536287095072426e-06 0.005492 5
112 CTGF_2 0.0000000009 0.00015265799477510392 / 0.004284835035004821 / 0.005655033062620194 / 0.017812704981803436 / 0.00018190158542752172 5.263266054115357e-07 / 4.3695038068811766e-08 / 3.7740283990797325e-06 / 7.135038004681359e-07 / 2.643168822853883e-05 0.005617 5
113 DAP_1 0.0000000596 0.008158453075892491 / 6.392429369799613e-05 / 0.01165101001080378 / 0.00706078944078839 / 0.0012146763275784356 1.4736850125189888e-07 / 3.908902039015359e-08 / 1.7628401584823726e-07 / 1.5347002454072624e-05 / 1.7507947709175734e-05 0.00563 5
114 PHOX2A_1 0.0000003175 0.008158453075892491 / 6.392429369799613e-05 / 0.00706078944078839 / 0.01165101001080378 / 0.0012146763275784356 5.8181933193632506e-08 / 1.1078332486685944e-07 / 1.2847626080278513e-05 / 1.9169572452878826e-06 / 1.3210118079992226e-05 0.00563 5
115 MVP_2 0.0000000015 0.0003074328712443293 / 0.029215443986862575 / 9.407443780393908e-05 / 0.0007597570913260385 / 4.843098209783887e-05 4.002114425736759e-08 / 1.6803136761019638e-06 / 3.376253203984945e-08 / 1.008528085216226e-05 / 4.819827094154422e-06 0.006085 5
116 CCNJ_2 0.0000000010 0.005156889617706872 / 0.0037116981070019926 / 0.018339330602739977 / 0.0005410238034488199 / 0.0029241900112892644 1.3384145050432693e-05 / 1.2259034650488922e-06 / 2.418247349561274e-06 / 5.022621230368505e-05 / 3.457954174876677e-05 0.006135 5
117 MAP4_5 0.0000000001 0.0005031786684884779 / 0.010922608465190551 / 0.018146216162979706 / 0.0003254856473440077 / 0.001272088116869848 2.587716794178391e-07 / 3.798173592497599e-08 / 2.5392647842825153e-06 / 4.942693897536645e-07 / 9.527740137246758e-08 0.006234 5
118 ATP5B_2 0.0000000014 1.0473941865935008e-05 / 0.00047787043862318663 / 0.02960215538361295 / 0.001031466405675943 / 0.00013666281877242411 7.117260294468996e-09 / 6.152782689367921e-07 / 1.526236991383182e-05 / 1.8976244710357432e-05 / 2.5507040748716144e-06 0.006252 5
119 TRAM2_3 0.0000000000 7.050716055970537e-06 / 0.0001057656674813077 / 0.0025449721290128477 / 6.997404830789269e-07 / 0.03280415443708167 5.729353647005044e-08 / 1.910962326072629e-07 / 8.344215866087099e-06 / 4.014110177183549e-06 / 1.7722857190857362e-05 0.007093 5
120 CCDC107_5 0.0000000004 7.799742935751802e-05 / 0.023152072094571645 / 0.014505125297696268 / 0.00010031692846422633 / 0.00039456234783499816 2.5979973718838742e-08 / 5.275125038891406e-07 / 1.2574262998000307e-06 / 4.826438486358518e-06 / 3.332582738649872e-06 0.007646 5
121 SMARCAD1_5 0.0000000000 6.51572554597248e-05 / 1.121807735413933e-05 / 0.0009794106383235514 / 0.028651749233987035 / 0.016373864330489554 4.951274541156556e-07 / 4.932698411729371e-06 / 3.7416170837321407e-06 / 2.232387301624823e-06 / 6.909674555415473e-07 0.009216 5
122 HRH1_1 0.0000009062 0.007112363650923645 / 0.007730255820425719 / 0.02421022399736038 / 0.001383098528892269 / 0.006385380233425884 8.024725118266073e-09 / 1.3814036761412276e-07 / 2.07690167148044e-06 / 1.4044796518330034e-05 / 1.4197658969421668e-05 0.009364 5
123 KHDRBS1_2 0.0000000015 1.6169392314406466e-05 / 0.0039056626487888758 / 0.0034273259551571168 / 0.03391386466641536 / 0.011666948417914267 9.514267607742899e-13 / 2.8566604252327994e-07 / 7.517707711246514e-07 / 4.1751581964055053e-07 / 9.055789447982931e-07 0.010586 5
124 E2F6_3 0.0000002841 0.0022254132117215356 / 0.0037188790361072878 / 0.005458005465302464 / 0.0014398907128301208 / 0.04086571019880003 4.421453475946776e-08 / 1.5392585786553033e-06 / 0.0003430693964816855 / 1.779882292403961e-06 / 0.0002956989113369879 0.010742 5
125 ELL2_2 0.0000000202 0.00011694820055399171 / 0.029386513254453968 / 0.005657975920541809 / 0.028459156083205858 / 0.01406740315871594 8.347517785439741e-08 / 1.2698717079911781e-06 / 1.917338652438103e-05 / 0.0001196727478086908 / 2.0681105855800244e-05 0.015538 5
126 BSN_2 0.0000022389 0.000506059688566897 / 0.04616500613759174 / 0.012649170673498711 / 0.005186853257558283 / 0.02830343719752466 5.0173732858781275e-06 / 1.1005994245083331e-07 / 0.00024710770557642556 / 0.00048732984216352446 / 0.00023929723037045147 0.018562 5
127 ATG4A_5 0.0000000000 4.475035366083391e-06 / 9.946560976238241e-06 / 1.150460981566587e-06 / 6.699525372343991e-05 2.070885361738112e-08 / 3.791151058200872e-07 / 2.8872435045296478e-08 / 0.00012711434042399471 2.06E-05 4
128 CD44_4 0.0000000000 4.4784520790283526e-08 / 2.3008815242152554e-05 / 5.2052109653188956e-05 / 0.00014533006515361492 7.884191479096678e-08 / 2.9710643899587148e-06 / 1.5781437020851443e-06 / 6.210975626614534e-07 5.51E-05 4
129 GSN_5 0.0000000000 3.785922406236843e-10 / 3.0058719101012673e-05 / 0.00029646205587575313 / 6.646730266541163e-05 8.816984894077637e-10 / 2.2588865060721033e-06 / 7.88507208198445e-05 / 4.284376587003957e-05 9.82E-05 4
130 CD99_5 0.0000000000 2.0149183113126577e-05 / 0.0006745061120899554 / 0.0002998852328395526 / 0.0001242923271196099 3.1338403532472386e-09 / 0.0006507487844929586 / 5.172267401380639e-06 / 9.968659271858592e-06 0.00028 4
131 GNAI2_5 0.0000000000 0.0005584151279765244 / 0.0003249499378752368 / 4.745051251091654e-05 / 0.00030759784724731154 4.982873808104418e-08 / 9.650800047119655e-07 / 2.454295952727384e-07 / 9.904904324446315e-05 0.00031 4
132 DDX60_5 0.0000000000 2.9212913515461393e-06 / 0.0001530409063220267 / 0.0003993610031162385 / 0.0010695426477561165 7.01839699594606e-08 / 2.0329686030779097e-06 / 1.4613415440657328e-05 / 1.702607599935211e-05 0.000406 4
133 MICALL2_3 0.0000000000 4.697595022472674e-06 / 6.457501817223296e-05 / 0.0015363886875154054 / 0.00014385763146450997 1.7875525723925519e-06 / 1.642694121565277e-07 / 1.8052618402003836e-05 / 5.8265193908577595e-05 0.000437 4
134 SOAT1_5 0.0000000000 0.001922385896174513 / 1.924383271682602e-06 / 2.782774586423633e-06 / 3.555527535100237e-05 7.936734231102217e-07 / 6.625132467195288e-08 / 5.379303522414254e-07 / 2.3383986457320025e-06 0.000491 4
135 PLEC_1 0.0000008789 4.778480179883678e-05 / 0.0006110060061203364 / 8.712601577854501e-09 / 0.0014562282237067896 2.8277390114780423e-07 / 2.166203983124237e-06 / 1.5583735231329512e-07 / 2.7125361005219603e-06 0.000529 4
136 XRCC5_1 0.0000000924 1.384655004104117e-06 / 0.0006273187563236247 / 2.098169823270148e-06 / 0.0014863302195178008 2.6130050369275158e-06 / 2.132206160555519e-05 / 2.4237849248550327e-06 / 0.00030699349223093454 0.000529 4
137 OSGEPL1_1 0.0000001116 0.00028286232014178015 / 0.00037839447623271325 / 0.001443320215490813 / 0.00010681753824403367 3.604572142413008e-06 / 4.082064229081972e-06 / 3.18593215315723e-06 / 9.670676646757636e-07 0.000553 4
138 TMEM97_4 0.0000000000 0.00018650020835883543 / 0.0004347886633272347 / 4.502684569031259e-06 / 0.0016700457783649062 3.3084881992489725e-06 / 4.754536166762309e-06 / 1.3093900089996567e-06 / 5.225302868715506e-05 0.000574 4
139 GLIS3_4 0.0000000000 0.0002286645360176498 / 0.0006619438558324503 / 0.0016620049728346326 / 1.1074671736457553e-05 1.510316419391924e-06 / 3.2409409252278102e-06 / 9.224875739627753e-05 / 1.930014755272634e-05 0.000641 4
140 ANXA1_5 0.0000000000 5.8551591866382045e-05 / 3.45022524746413e-05 / 6.004993403577111e-08 / 0.002751213558972749 2.397154304313467e-07 / 3.176106815413732e-06 / 6.107114335334353e-07 / 1.2210016577494943e-05 0.000711 4
141 FAM120A_5 0.0000000001 0.0026813412993839337 / 0.0005742956528301279 / 3.563997625540032e-05 / 8.528922868820983e-06 0.0001881828357253321 / 0.00012537124618201126 / 1.3817216627076195e-05 / 0.00011563779547673361 0.000825 4
142 SAFB_3 0.0000000001 0.001211277784043611 / 0.00011818878635236698 / 0.00029246473195964197 / 0.001769841813108865 7.668444452032125e-07 / 2.898461734945786e-07 / 2.8130419096127126e-05 / 0.00035040496082839104 0.000848 4
143 ACTN4_4 0.0000000000 1.4106395746220967e-05 / 8.221349715218104e-05 / 0.003449453406084509 / 0.0001267717634392765 3.3938237122738275e-07 / 1.2062404978268685e-06 / 4.0239968184075355e-06 / 2.990385220556594e-05 0.000918 4
144 FAM117B_5 0.0000000000 0.00014565693019513351 / 0.0006387724048262495 / 2.041989162397474e-07 / 0.00308065083431233 1.2462660948443544e-05 / 4.0378352806812125e-06 / 4.5557593081500904e-08 / 6.255861262356289e-05 0.000966 4
145 TSSC1_1 0.0000008042 0.0010281262291342236 / 0.0008973831238703076 / 0.0014311836039126026 / 0.0005658979552839525 4.773040777006663e-07 / 1.293648273273451e-06 / 1.370737279606987e-06 / 6.872239294614834e-08 0.000981 4
146 SERPINE2_1 0.0000006237 8.712601577854501e-09 / 0.003917317274808632 / 4.778480179883678e-05 / 0.0006110060061203364 4.293656906359287e-09 / 7.59699887090359e-07 / 2.4805326670497096e-06 / 2.6318189672753774e-06 0.001144 4
147 IFNAR1_5 0.0000000000 1.6950082284852724e-05 / 0.00023259440421303834 / 2.145061357704084e-05 / 0.006168307042686711 2.6777259205549025e-06 / 3.126328063081149e-07 / 1.6378968792487728e-05 / 1.980502151445686e-05 0.00161 4
148 UEVLD_3 0.0000000002 0.0025817513756711884 / 0.0002058200859707558 / 0.0001532402705811572 / 0.003951386408683102 1.7719417389393089e-06 / 1.5327037128336517e-08 / 5.132415043139141e-08 / 8.649188479247404e-07 0.001723 4
149 GUF1_5 0.0000000000 5.893107805476978e-05 / 0.007964457709027949 / 4.303196745477378e-05 / 2.6967345038980607e-05 3.970170459579241e-07 / 2.864249504984967e-06 / 3.435012765675232e-07 / 1.5389318932784949e-06 0.002023 4
150 GBP3_1 0.0000015823 0.0019027179320774803 / 0.0003168019030192227 / 0.004613449756294485 / 0.0012733956455115425 1.8104358020946005e-07 / 2.2473742888087726e-07 / 3.977899627306711e-05 / 5.118490443586335e-06 0.002027 4
151 MED28_1 0.0000032077 0.0003168019030192227 / 0.0019027179320774803 / 0.004613449756294485 / 0.0012733956455115425 2.9684923703899697e-07 / 6.654843522911474e-07 / 3.1176140675136144e-06 / 3.225376490885068e-06 0.002027 4
152 SLC2A10_1 0.0000000972 0.0019027179320774803 / 0.0003168019030192227 / 0.004613449756294485 / 0.0012733956455115425 1.7631746614895863e-07 / 2.4782620652363583e-09 / 6.763392837610305e-07 / 2.321466389902454e-06 0.002027 4
153 CBR3_1 0.0000000238 0.0003168019030192227 / 0.0012733956455115425 / 0.0019027179320774803 / 0.004613449756294485 7.910872738545078e-09 / 1.4202365174097019e-08 / 5.43796956141398e-07 / 4.674686520121403e-05 0.002027 4
154 HIC2_1 0.0000007789 0.0019027179320774803 / 0.0012733956455115425 / 0.004613449756294485 / 0.0003168019030192227 3.0633550655698566e-10 / 2.1696779182322382e-09 / 2.2828231685954628e-07 / 2.4650085263362296e-06 0.002027 4
155 IGSF9_1 0.0000004185 0.0012733956455115425 / 0.0003168019030192227 / 0.004613449756294485 / 0.0019027179320774803 3.3765982883653153e-06 / 2.559009185958782e-07 / 1.2961469049521693e-06 / 8.135407791689286e-05 0.002027 4
156 RCAN1_1 0.0000010839 0.0019027179320774803 / 0.004613449756294485 / 0.0012733956455115425 / 0.0003168019030192227 3.52499926166527e-09 / 1.4195702150916024e-07 / 2.8012155247278448e-06 / 8.591081719368746e-08 0.002027 4
157 SAFB_1 0.0000022906 0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227 / 0.0012733956455115425 1.2527049345521191e-06 / 1.2341574556015853e-07 / 4.073201704051311e-08 / 5.976596803731563e-06 0.002027 4
158 HNRNPA0_2 0.0000000370 0.0009389452362024158 / 0.0004583304262309702 / 2.0318525623421967e-06 / 0.006886174737452949 6.591983136046331e-08 / 2.1078089903628105e-05 / 2.1991513327880328e-05 / 6.211957230218145e-05 0.002071 4
159 ISL1_1 0.0000000008 0.0014562282237067896 / 8.712601577854501e-09 / 4.778480179883678e-05 / 0.008799197542964286 4.47926130890511e-10 / 1.3159792563051542e-10 / 1.6267903098803325e-06 / 8.859331058014511e-06 0.002576 4
160 PPIC_1 0.0000008150 1.1499890891595663e-06 / 0.0023486428669150803 / 0.004509729888699788 / 0.003649857824379229 6.181851966897516e-08 / 4.336126091570401e-07 / 1.130291682742051e-06 / 5.702819528263402e-06 0.002627 4
161 CBX1_1 0.0000073072 0.00920357999307954 / 0.00020520490391129044 / 0.0014863302195178008 / 2.098169823270148e-06 3.4308469313672e-05 / 0.00016072496067379242 / 0.000416531131321131 / 1.1909250396666738e-05 0.002724 4
162 ARID3B_1 0.0000039314 0.0012733956455115425 / 0.0019027179320774803 / 0.004613449756294485 / 0.0034947768260440494 5.689363226662423e-09 / 3.5223565854980375e-06 / 2.7692513603614087e-06 / 7.767239795505205e-06 0.002821 4
163 RNF157_1 0.0000017210 0.004531342266561176 / 0.0026490796375761676 / 0.0016555906467057811 / 0.0030838618137353662 1.0799957008656176e-05 / 7.097149358472166e-05 / 4.819541314832769e-07 / 7.676415694714317e-07 0.00298 4
164 EIF3L_2 0.0000000102 0.005135657485519335 / 0.005326745976664332 / 0.0017435819308224765 / 7.384136449790188e-06 1.8190521073639574e-10 / 1.0527503241568249e-06 / 4.518548487460203e-06 / 1.3638553131166296e-06 0.003053 4
165 SLC25A43_2 0.0000000002 0.00014847770954858836 / 0.0010357469368733494 / 0.0010144217502109298 / 0.010259629272911746 3.357035874085631e-07 / 7.382332140811268e-07 / 2.131827740313582e-06 / 3.004944425021926e-05 0.003115 4
166 OLFML2A_1 0.0000000021 0.0014562282237067896 / 8.712601577854501e-09 / 0.0006110060061203364 / 0.010748894710017389 1.2437444351849456e-10 / 1.877118300185312e-10 / 1.270455283512457e-06 / 1.2117974236888312e-06 0.003204 4
167 HNRNPA1L2_4 0.0000000000 3.055750323559003e-05 / 0.013700253988565498 / 3.881898534012908e-05 / 4.532481843678641e-08 9.763383363669304e-09 / 6.413557230739407e-06 / 1.1996173334605904e-08 / 2.6326526346171393e-08 0.003442 4
168 GPR125_1 0.0000015939 0.0004338260851758113 / 0.005078710464709388 / 0.005770181686062503 / 0.0025299472548494955 8.375396341394661e-06 / 1.2620826876929007e-07 / 5.037605201133463e-06 / 4.397437068329601e-06 0.003453 4
169 HFM1_5 0.0000000000 4.6027629362357145e-06 / 2.054289713438471e-06 / 0.010747113861164049 / 0.0030735298911349954 5.2804634950801046e-08 / 1.3823733955490087e-07 / 0.0002289318652341564 / 0.00017922188693161184 0.003457 4
170 FAM161A_3 0.0000000004 1.1900765556084342e-06 / 6.104336159313168e-05 / 0.0038692378656813085 / 0.010450418229319037 7.836775108119704e-06 / 4.602994442160525e-06 / 0.0014084623238924201 / 0.006437120167388166 0.003595 4
171 MYO1E_5 0.0000000000 9.1301369378943e-07 / 3.6970513366191076e-05 / 0.014560624799721568 / 0.00044473645621912025 1.563633164899415e-07 / 6.6703997984050774e-06 / 0.0002544952895081012 / 1.2369712374983664e-06 0.003761 4
172 BHLHE40_2 0.0000000008 0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 / 0.012364148039779468 3.6750231825447993e-09 / 1.3797224307526888e-10 / 4.5238117998428525e-10 / 1.4503164618207844e-05 0.004009 4
173 IPO9_1 0.0000001864 0.00706078944078839 / 6.392429369799613e-05 / 0.0011036487237694873 / 0.008158453075892491 7.925030915673659e-07 / 2.436316843178784e-07 / 2.7933385967164893e-06 / 3.7162081746516914e-06 0.004097 4
174 MALT1_5 0.0000000000 8.286399528571891e-06 / 0.0002461865995006486 / 0.00023833137981344143 / 0.016843325771737905 3.375997586023991e-08 / 1.2071446047409586e-07 / 1.095602481975961e-06 / 2.6082135535498982e-06 0.004334 4
175 GDPD1_1 0.0000033642 0.008597087236259153 / 0.002859168680149655 / 0.0007069744136606002 / 0.005851685675009941 9.233213274811235e-08 / 3.5536116052273754e-07 / 2.1037456632604637e-07 / 1.3670539309103289e-05 0.004504 4
176 CLIC1_5 0.0000000000 0.00048798421080350877 / 0.003091093830161087 / 0.005843494432330533 / 0.008851783624153233 3.133239901460721e-08 / 1.3305262196278536e-08 / 4.3396495831301414e-05 / 1.8259140204877226e-06 0.004569 4
177 GBP1_1 0.0000000190 0.00029139375190295606 / 0.008770410107355643 / 0.009220967328515883 / 7.763485144629643e-05 2.034005959874992e-08 / 1.025777265986079e-05 / 3.7717113262051256e-06 / 6.322665753334008e-05 0.00459 4
178 WDR1_4 0.0000000063 0.00018307154229595032 / 0.0002457066480750095 / 0.0005563718559501817 / 0.01757082718712336 1.4158768736111935e-07 / 1.8926145330443176e-07 / 3.145940065328651e-05 / 2.00918389447038e-06 0.004639 4
179 NOLC1_1 0.0000002124 0.005497026258977277 / 0.0037411319458859455 / 0.001569082671062799 / 0.009893561180811163 1.0104488773237543e-08 / 7.714332997539589e-07 / 2.1884817904926247e-06 / 3.370149988961001e-05 0.005175 4
180 SUCLG2_1 0.0000002256 0.0008973831238703076 / 0.0060047412034100744 / 0.013949817553702996 / 3.679473658399758e-05 4.6445581997855444e-07 / 0.00013589105082118295 / 6.517922811200161e-07 / 3.2332580875235436e-06 0.005222 4
181 TMEM50B_4 0.0000000000 0.00021033920160836247 / 3.048709751971941e-06 / 7.4963019248993875e-06 / 0.02190343894897618 4.260473533327541e-07 / 3.0953447432169544e-06 / 1.0406702632518272e-05 / 6.714065008670566e-05 0.005531 4
182 TEP1_2 0.0000000008 0.00044390649641880996 / 0.00022291138567452008 / 0.007728913610011587 / 0.013802397731305673 7.69344257098905e-08 / 7.583371932539051e-07 / 1.1452916356973667e-05 / 1.4951877455973638e-05 0.00555 4
183 C1QTNF4_1 0.0000065502 0.018168011703420802 / 0.0008739549079227278 / 0.0021525218115003323 / 0.001823497355076137 1.4609518924208137e-05 / 1.9886833860209337e-08 / 3.327674138498291e-05 / 4.1425752762924387e-07 0.005754 4
184 SAMD9_2 0.0000000241 0.00015888299030502074 / 0.0005649656249134306 / 0.02294011174111297 / 2.9781970809395596e-05 1.4515338714501776e-07 / 1.0069662929413845e-06 / 3.079017964078163e-05 / 2.9239260560336778e-06 0.005923 4
185 INTS2_1 0.0000015748 0.0071423807687498436 / 0.005409509534570436 / 0.012055857526605073 / 1.7711409436331332e-05 3.636941582614834e-06 / 8.403767627067496e-07 / 0.000275721623498196 / 3.367956926486663e-05 0.006156 4
186 FUBP1_1 0.0000511078 0.00130787641161479 / 0.004251874133389083 / 0.003364552119188696 / 0.015851508245258043 1.9108608392104508e-07 / 2.9841202780652124e-07 / 5.350933661523097e-06 / 2.1932160234548787e-07 0.006194 4
187 RPAP1_1 0.0000410735 0.02301236512624726 / 0.0005345944155461007 / 0.001243129263120806 / 0.00047465333000177624 3.176104797820964e-07 / 2.5190175338691726e-06 / 2.1523203092437045e-06 / 9.149396149972693e-07 0.006316 4
188 HEXB_1 0.0000076128 0.015529327313804105 / 0.0013546126949011356 / 0.0060782790336966815 / 0.0035812987621354486 6.42491318793146e-10 / 4.577473133930505e-08 / 3.39530943939453e-09 / 2.7122303773993426e-06 0.006636 4
189 HNRNPU_1 0.0000032015 3.772462305351297e-05 / 0.00064922210107833 / 0.0010438255846085224 / 0.026018704719089503 1.000463952367771e-07 / 2.638911239632533e-07 / 7.660492345043258e-07 / 4.407301801134979e-06 0.006937 4
190 FUCA1_2 0.0000000004 7.228979888741317e-05 / 0.013714832441879614 / 0.007971606520234983 / 0.007402461335311882 2.0988769570938153e-06 / 1.9872137311126255e-06 / 3.537000242989197e-06 / 9.575754350455543e-05 0.00729 4
191 NOTCH2_2 0.0000000072 0.006230846374778002 / 0.003851986494620127 / 0.0034437522016521897 / 0.015866838196212218 1.4454100512704434e-07 / 8.519702743163462e-07 / 9.796096746463353e-06 / 3.089459803795722e-05 0.007348 4
192 CCT4_1 0.0000020961 0.0004974933526793384 / 0.008397433522606995 / 0.008173144283430401 / 0.012491622786737646 2.7241251268074896e-08 / 1.4220454346358598e-06 / 8.270539706935099e-07 / 7.806294817192854e-06 0.00739 4
193 UTRN_3 0.0000000000 2.360823500030083e-06 / 4.819891610542341e-05 / 0.01459161774480625 / 0.01624353394689184 9.96939171389334e-09 / 5.260467316300094e-07 / 3.5243167304031697e-06 / 9.884600038679634e-07 0.007721 4
194 CALU_1 0.0000004164 8.712601577854501e-09 / 0.029987683740818265 / 4.778480179883678e-05 / 0.0014562282237067896 5.266009225225312e-10 / 4.0454271359773727e-07 / 7.672203291248733e-08 / 5.85093501886766e-06 0.007873 4
195 PLAUR_1 0.0000000244 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 / 0.029987683740818265 8.615162127229272e-11 / 9.681579901416002e-07 / 1.4437165409807745e-06 / 9.35433381095111e-06 0.007873 4
196 HIST1H3F_2 0.0000000051 0.0015927321289850582 / 0.023851866632585955 / 0.00016090253762067176 / 0.006218991828298577 2.1956145641009148e-08 / 0.00010324111552331347 / 6.744350520658004e-06 / 6.501852523462225e-05 0.007956 4
197 SHF_2 0.0000000138 0.001693689356850199 / 0.0014031215699221884 / 0.012735358967208718 / 0.017175407042679062 1.935898724207595e-07 / 7.846392075982059e-07 / 9.678320481712436e-06 / 8.427515550712705e-07 0.008252 4
198 CERK_1 0.0000008873 0.013244448613132145 / 0.0022351613397075614 / 0.015474072817082456 / 0.0029744892448975834 0.00020051688200258856 / 0.00018492952950495273 / 0.0012280052280709938 / 0.0005416554989378981 0.008482 4
199 TADA1_1 0.0000002147 0.016780696985377475 / 0.0005695162353950492 / 0.009231171890260521 / 0.00772762240557102 1.4508371309511671e-08 / 6.435719575006254e-08 / 4.82397274391162e-08 / 2.779770649698667e-07 0.008577 4
200 UBA7_1 0.0003624359 0.0005728902408745853 / 0.003242823752914826 / 0.0027568341257606386 / 0.03172797440821663 4.377541835767184e-08 / 1.4020761197150485e-06 / 2.9401803878641854e-05 / 6.058178438606368e-07 0.009575 4
201 SETDB1_1 0.0000003780 0.0026490796375761676 / 0.0030838618137353662 / 0.0004052971561229435 / 0.03955358967054088 5.084831070504725e-08 / 1.5437307336972335e-08 / 2.4314077044074555e-08 / 3.708419532637195e-06 0.011423 4
202 FEV_1 0.0000018489 0.033538144332397844 / 0.00028614552404424633 / 0.01249350392911133 / 5.910503776729101e-05 3.513392334373485e-06 / 3.0193991188193814e-06 / 4.261681658726496e-06 / 3.904348041550831e-06 0.011594 4
203 PLIN3_1 0.0000052675 0.00029139375190295606 / 0.009220967328515883 / 0.03147989324458417 / 0.008770410107355643 4.751419536263273e-07 / 1.5878609213360564e-06 / 2.5660205514983566e-05 / 1.1850407245136544e-05 0.012441 4
204 CAPZB_1 0.0000074431 0.020797363705116343 / 0.0062029903117365925 / 0.01708229147040032 / 0.012228646417111324 3.430820753789497e-07 / 7.116750242001532e-06 / 1.9457058230691574e-05 / 1.4739355201517365e-06 0.014078 4
205 PRR14L_1 0.0000287853 0.025082579510674555 / 0.0002021790532799894 / 0.012782548244800053 / 0.01903033340546255 3.0568724876555808e-06 / 1.7592986743744327e-05 / 0.0003036464804643225 / 9.900533456095719e-05 0.014274 4
206 SYT4_1 0.0000045133 0.015545833082593517 / 0.02041517410701112 / 0.005606155017185667 / 0.023315264256491483 0.0007991296587415927 / 1.5782237178697584e-07 / 3.4514435206822334e-06 / 3.6363448556754176e-05 0.016221 4
207 OSTM1_1 0.0000004769 0.00029139375190295606 / 0.014437131210731376 / 0.008770410107355643 / 0.042521980850760616 1.8325191636828767e-09 / 1.7933002396456563e-06 / 1.209386955631816e-05 / 2.8665654575872185e-06 0.016505 4
208 ALKBH2_5 0.0000000000 0.0006658217635395392 / 6.408084768025853e-06 / 0.04987195778126702 / 0.025098765971631444 1.084736492711166e-08 / 9.593642946100947e-08 / 1.132197770977069e-05 / 2.191320769137121e-05 0.018911 4
209 MSN_1 0.0000002383 0.01695446499444467 / 0.027498564129629463 / 0.014675290351873422 / 0.018771777160462803 4.599537647191073e-06 / 1.9086619291135215e-05 / 4.8131935092059315e-06 / 1.3273993329378002e-05 0.019475 4
210 ESYT2_2 0.0000000013 0.0030336578784421852 / 0.01671859601940339 / 0.015226777755356039 / 0.04496562784687137 3.165663675076115e-09 / 2.3423418225839996e-05 / 5.032307286753409e-07 / 1.2411450689986321e-05 0.019986 4
211 RSBN1_1 0.0000185080 0.03683753470884825 / 0.011413935706631708 / 0.017145541610166553 / 0.014660785392642973 1.433152382574118e-07 / 5.910344738541638e-08 / 2.5220601123022208e-05 / 4.2656913152557095e-06 0.020014 4
212 ATL3_1 0.0000008573 0.011413935706631708 / 0.014660785392642973 / 0.017443397981769932 / 0.03683753470884825 2.938478701650645e-07 / 1.2357184821505046e-06 / 1.34699746919262e-06 / 4.381675501436861e-06 0.020089 4
213 GLCCI1_2 0.0000000339 0.000506059688566897 / 0.006967423038249733 / 0.04616500613759174 / 0.02830343719752466 2.756128143638523e-10 / 8.727903434920509e-10 / 5.197443718190881e-07 / 0.00016721014291291134 0.020485 4
214 STX4_1 0.0000103251 0.017443397981769932 / 0.017145541610166553 / 0.03683753470884825 / 0.011413935706631708 1.149596541548471e-07 / 9.1652846360952e-06 / 2.8282830819547243e-06 / 3.479429274497365e-07 0.02071 4
215 ZFP36_1 0.0001056505 0.017443397981769932 / 0.017145541610166553 / 0.011413935706631708 / 0.03683753470884825 1.737842213973009e-07 / 8.045110852931203e-06 / 6.077495271342403e-05 / 1.3331815375742793e-06 0.02071 4
216 ITPR3_1 0.0000001347 0.04001855602158032 / 0.02473369613058651 / 0.002494297125613762 / 0.017644496874256163 3.1111051486214713e-07 / 3.1246898169649434e-07 / 5.066474066266959e-07 / 6.524401461141414e-06 0.021223 4
217 APEX1_1 0.0000125684 0.029245906890336886 / 0.039756863847419444 / 0.012044249045532097 / 0.005547335178190005 7.501855120464028e-09 / 2.210591549312696e-06 / 0.0010048532388054296 / 7.598158853857719e-07 0.021649 4
218 NAGK_1 0.0000090434 0.0359209982666861 / 0.02283925689865032 / 0.03203446148966057 / 0.007869203029856895 4.857892768176024e-12 / 1.5321698605219521e-06 / 3.1094588442870684e-07 / 1.03713103228835e-07 0.024666 4
219 CTSO_2 0.0000000001 0.011266491236640721 / 0.04019864979524411 / 0.009925247376618809 / 0.049822690026412035 3.138972714567624e-08 / 1.560503101825122e-08 / 9.567048792824493e-06 / 1.998510033084769e-06 0.027803 4
220 GAL3ST3_5 0.0000000000 1.4966990682807468e-07 / 2.827249605742276e-06 / 3.1413408717447276e-05 3.0226583395773654e-07 / 4.251989568762905e-06 / 9.932757607291931e-07 1.15E-05 3
221 UBA52_3 0.0000000000 1.3603516623392527e-05 / 6.029043389123571e-05 / 5.045497445639472e-05 5.851551410932261e-07 / 1.710172873999253e-08 / 1.2158482126235317e-05 4.14E-05 3
222 MSRB3_4 0.0000000000 6.46451222732421e-05 / 3.720566971124837e-05 / 8.695780204681589e-05 7.267015459944046e-07 / 4.887970470660509e-05 / 6.751019417131056e-05 6.29E-05 3
223 MTPAP_3 0.0000000001 2.4720937454568888e-05 / 1.2751616501556023e-05 / 0.00018587383065277118 4.2193212858195527e-07 / 3.403424981067467e-07 / 1.255056828139161e-06 7.44E-05 3
224 UBE2O_4 0.0000000000 0.00020771366206680562 / 1.528305625592724e-05 / 1.5417123239589966e-05 8.204970746839372e-07 / 1.2473665471568327e-05 / 2.207999415422632e-05 7.95E-05 3
225 RANBP17_1 0.0000004613 0.00013057839781136293 / 2.098169823270148e-06 / 0.00012418009082273935 1.5462113719102461e-06 / 1.0841250457737996e-05 / 0.0007974404623478325 8.56E-05 3
226 ZNF516_4 0.0000000000 3.872664033406607e-06 / 0.00012352623655085027 / 0.00014080284226678161 8.633851745836879e-06 / 3.646126773929292e-05 / 4.693534198442505e-05 8.94E-05 3
227 NKAIN1_3 0.0000000000 6.048904209077932e-07 / 0.0002827019572692268 / 4.565055181871741e-06 1.8963600971928307e-07 / 2.4597415093902517e-05 / 8.312648483856273e-05 9.6E-05 3
228 DHX9_3 0.0000000000 0.00031618213746396326 / 1.5079640407764188e-07 / 3.878104391115258e-05 7.324325851139409e-08 / 8.345673558891845e-07 / 5.455940168964712e-06 0.000118 3
229 TET1_4 0.0000000000 7.04443145456897e-05 / 0.00013097208813100302 / 0.00017715535475236788 7.420704863880182e-07 / 1.871920932527521e-06 / 1.2498158253814596e-06 0.000126 3
230 UHMK1_1 0.0000020860 0.00030051214168214937 / 6.606509042863372e-05 / 9.390951294242489e-05 5.795453634595254e-08 / 9.135482956883646e-09 / 5.202287615781549e-07 0.000153 3
231 KCNH8_2 0.0000000000 6.395893878746714e-08 / 0.0004951577945428809 / 6.246855784844429e-05 1.8797523362973878e-08 / 4.636654129462014e-07 / 1.099671115182553e-06 0.000186 3
232 PMEL_1 0.0000005663 2.098169823270148e-06 / 1.384655004104117e-06 / 0.0006273187563236247 6.845101785005541e-09 / 2.3534233465189457e-06 / 7.679394256913984e-07 0.00021 3
233 TMEM177_2 0.0000000000 0.000218258066644831 / 2.729001089528698e-05 / 0.0005268025057445726 5.209193027162048e-08 / 7.210516358215353e-07 / 8.65292135655517e-06 0.000257 3
234 P4HB_3 0.0000000000 7.235087963937188e-05 / 0.00020977095849751892 / 0.0006140291296563689 1.5481316963269385e-06 / 1.2667727790601262e-05 / 2.2318101021362054e-05 0.000299 3
235 GLB1_2 0.0000000001 0.0008060555543976513 / 0.00015263556465626687 / 0.0002492824297492718 5.95245025264109e-07 / 3.0646460084359855e-06 / 2.0252846047441925e-05 0.000403 3
236 NIPSNAP1_5 0.0000000000 7.0049869888978436e-06 / 0.0005153457051148798 / 0.0006955168425803274 1.5111991034910146e-07 / 1.7955354168874533e-06 / 6.9569188414230535e-06 0.000406 3
237 STOX2_4 0.0000000003 4.1961269753906035e-05 / 0.0010880952015806498 / 0.00010503474822771901 8.316576707748038e-07 / 1.514815251496678e-05 / 3.9477756451806046e-06 0.000412 3
238 HIC2_5 0.0000000000 4.726033274744903e-06 / 0.00013382198113446112 / 0.0013349789650252575 9.611997971680818e-09 / 1.1620332716585593e-05 / 3.9355477345741505e-05 0.000491 3
239 DDX25_1 0.0000003731 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 1.6097112876531916e-08 / 3.2052124199850265e-08 / 1.4170604850554317e-07 0.000501 3
240 DNMT3A_1 0.0000003165 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 3.5247387941347504e-08 / 6.731804150774537e-06 / 1.2896794234236179e-05 0.000501 3
241 EXT2_1 0.0000003436 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 2.0783635717550663e-12 / 9.054121086432515e-07 / 2.0219531513922313e-05 0.000501 3
242 FAM129B_1 0.0000000190 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 6.60672131957345e-08 / 5.537377478544649e-08 / 4.1732948235118237e-07 0.000501 3
243 GINM1_1 0.0000002753 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 5.046050215569822e-09 / 5.428070521726932e-08 / 2.1701147223144043e-06 0.000501 3
244 HNRNPA1L2_1 0.0000000756 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 1.2976171138488909e-09 / 4.5877377333254656e-07 / 1.6836213911883948e-06 0.000501 3
245 MAN1B1_1 0.0000001522 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 3.0241063676746706e-11 / 1.5906368364620238e-09 / 1.318311055073274e-07 0.000501 3
246 TACC1_1 0.0000024323 0.0014562282237067896 / 4.778480179883678e-05 / 8.712601577854501e-09 6.120199026321514e-07 / 4.1123437302256347e-07 / 1.0614723925305345e-08 0.000501 3
247 RIPK1_5 0.0000000000 6.840228317523313e-05 / 0.0009512875629473391 / 0.0005924452898671693 1.5712671052120772e-06 / 4.09648566039462e-06 / 3.7135622189006208e-06 0.000537 3
248 ZBTB4_3 0.0000000000 0.0005037641948066041 / 4.1029029786791e-05 / 0.0011809756046229313 1.117525634308104e-05 / 2.721755300189734e-07 / 5.303486617820998e-05 0.000575 3
249 TLN1_5 0.0000000000 1.9703021048281005e-05 / 0.0005523542769980133 / 0.001186882005547644 2.022661269835003e-07 / 7.938143861075808e-05 / 8.872728066213042e-06 0.000586 3
250 PCBP3_1 0.0000002605 8.712601577854501e-09 / 0.0006110060061203364 / 0.0014562282237067896 7.776240359663578e-08 / 1.638864761384365e-06 / 1.2093871604348117e-06 0.000689 3
251 KIDINS220_2 0.0000000000 0.0018859337356087994 / 0.0001930893136831812 / 4.710776942634132e-06 5.072414419210524e-06 / 1.9800037664169994e-06 / 3.568737378774764e-05 0.000695 3
252 MYH9_4 0.0000000000 0.0011716362540399527 / 2.5874889458489842e-05 / 0.00098592835353018 1.1606044222659936e-05 / 5.315659303841256e-07 / 0.0002008409108671274 0.000728 3
253 C2orf43_4 0.0000000000 5.393578869543922e-07 / 0.0023453445326236527 / 1.354525793237082e-06 6.595211500412567e-08 / 3.985671655723259e-07 / 6.693718279433329e-07 0.000782 3
254 CFLAR_5 0.0000000000 2.366050283623384e-07 / 1.8250670479244966e-06 / 0.0026884317876910953 4.986931710131805e-06 / 3.457834181885606e-06 / 1.5979548021423277e-06 0.000897 3
255 RAB27A_5 0.0000000000 4.235470787154264e-07 / 0.00048364115746124477 / 0.002294886679155574 1.5348969527407146e-08 / 1.8046897740630015e-06 / 4.1788406415060826e-05 0.000926 3
256 PLSCR4_2 0.0000000029 4.859413804591664e-05 / 0.0027548209719256856 / 0.00020561631972662475 3.3117537208770918e-09 / 1.148805004150062e-06 / 4.664969309642537e-06 0.001003 3
257 RPUSD4_1 0.0000007330 0.001066805887839933 / 0.0005152101842532016 / 0.0015298583359982347 2.3615410532322286e-05 / 4.319838908046999e-06 / 0.0002330489716331065 0.001037 3
258 MPST_3 0.0000000016 0.00013736583753548478 / 0.0030443962453463847 / 8.033145753215765e-06 3.289559261620218e-06 / 3.976886270875369e-06 / 1.171567023312239e-06 0.001063 3
259 MSN_1 0.0000002015 0.0019027179320774803 / 0.0012733956455115425 / 0.0003168019030192227 9.67855150073715e-08 / 3.184222031943731e-08 / 4.6792815745596373e-07 0.001164 3
260 TGFB1I1_1 0.0000000689 0.0012733956455115425 / 0.0003168019030192227 / 0.0019027179320774803 9.602262969345956e-07 / 1.898080280214667e-06 / 4.85147907436071e-06 0.001164 3
261 PRMT1_2 0.0000000003 2.8649381309321584e-06 / 0.00013104001909797732 / 0.00341452788547584 3.7442073966474697e-11 / 2.696236533103196e-06 / 4.175789992611833e-06 0.001183 3
262 AGPAT3_3 0.0000000000 0.0009240199113069562 / 0.001726211324732259 / 0.0009222051384671301 1.4076606607890667e-05 / 6.064432655122854e-06 / 0.00046211741435037205 0.001191 3
263 NUPR1_2 0.0000000008 1.2731341624968911e-05 / 5.8997927541035875e-06 / 0.003561757705418032 6.730910090199648e-07 / 2.3445593630205304e-06 / 1.3063148311515809e-05 0.001193 3
264 RNPC3_2 0.0000000375 0.0025602598027028244 / 5.469917899643988e-05 / 0.0010104633264639477 1.393467985718326e-06 / 7.829150593953611e-07 / 0.00010845460486238517 0.001208 3
265 S100A6_2 0.0000000006 0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 1.7609429749647884e-07 / 5.870724758098998e-07 / 1.1681749490132842e-07 0.001224 3
266 GADD45B_2 0.0000000000 0.00010634683697229356 / 0.003790365456096317 / 1.8397621446509385e-05 1.705317052907576e-07 / 8.878912678862584e-06 / 2.2556761049368962e-07 0.001305 3
267 IRF2_2_5 0.0000015405 0.0008574554508689445 / 0.003180287587180633 / 6.994095656900796e-05 9.872538086030946e-08 / 1.5355274708245824e-06 / 2.245172851097339e-06 0.001369 3
268 MVP_2_3 0.0000000046 0.00024759203487775524 / 1.1168409277359634e-06 / 0.004671632294386495 1.4353154937155882e-08 / 5.633740184888267e-07 / 7.385772453731096e-05 0.00164 3
269 GTF2H5_2 0.0000000066 0.0002128703129063878 / 0.002908963894359682 / 0.0018958315428404735 5.915610064271708e-09 / 5.737302226316655e-07 / 1.2839131009976642e-05 0.001673 3
270 AGTPBP1_2 0.0000000112 0.00010643560926875712 / 0.0014494282385407017 / 0.003851986494620127 3.4005559000932834e-05 / 5.086114917232466e-05 / 2.3120980016650736e-05 0.001803 3
271 TAGLN2_5 0.0000000000 0.0023516155321212286 / 0.0005452799037971314 / 0.002719578191920108 5.193860370029491e-08 / 1.8066076033567137e-05 / 2.887575861701981e-05 0.001872 3
272 CCNT1_4 0.0000000000 0.00022838881607180578 / 2.554651598059182e-05 / 0.006324061390967165 5.780726368884951e-06 / 4.298018160630921e-06 / 8.210854046814278e-06 0.002193 3
273 KCNN4_1 0.0000000002 0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227 1.128508207742848e-07 / 3.8845776675460915e-08 / 1.2490905944573221e-07 0.002278 3
274 PEA15_1 0.0000000021 0.004613449756294485 / 0.0003168019030192227 / 0.0019027179320774803 3.828734914704096e-08 / 3.8329007469588033e-07 / 4.539908056270449e-05 0.002278 3
275 SAMD9_1 0.0000020075 0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227 1.631780084189698e-08 / 1.293907975082848e-05 / 2.4553942312433883e-05 0.002278 3
276 TRADD_3 0.0000000103 0.0009229889305125405 / 0.005966882987573243 / 0.00022527887387849618 1.9518812703705133e-06 / 0.0006939505597308152 / 1.9336719955298165e-06 0.002372 3
277 TAF5_3 0.0000000136 0.0003947059228531657 / 0.00045641021220350523 / 0.006335832620557736 1.7233340819541832e-07 / 2.5952887221237527e-06 / 8.18333648588888e-05 0.002396 3
278 EFHD2_4 0.0000000000 0.00723849757956334 / 1.3696651981584819e-05 / 6.311409747603608e-05 2.4861210722153842e-05 / 2.247788787753732e-05 / 1.516759330888414e-06 0.002438 3
279 YIPF2_1 0.0000006993 0.0008973831238703076 / 0.0005658979552839525 / 0.0060047412034100744 9.922731214680193e-08 / 7.852806908257148e-06 / 0.0001985413552316056 0.002489 3
280 ZBED4_2 0.0000001314 0.0007128826028020409 / 0.0020168985989813806 / 0.00482573534583834 9.098868701321864e-08 / 1.2243260078905274e-05 / 0.0008067113425139145 0.002519 3
281 RAB3C_1 0.0000014208 0.0012733956455115425 / 0.004613449756294485 / 0.0019027179320774803 5.90994322935669e-07 / 1.1108797731264583e-05 / 4.4376112397274685e-05 0.002597 3
282 FOSL1_4 0.0000000000 0.007490059087712426 / 0.00021444125068471832 / 0.00012920787797071663 5.556372147557157e-06 / 7.999218077760667e-07 / 2.9367679374215882e-05 0.002611 3
283 INA_2 0.0000002325 0.000506059688566897 / 0.006967423038249733 / 0.000365164824725025 2.655622703010865e-07 / 6.037515871423344e-07 / 0.001167614468808287 0.002613 3
284 FLVCR1_2 0.0000000042 5.3340489000579145e-05 / 0.0015899100236963135 / 0.006521228618588356 1.302715543173824e-07 / 3.714456265544689e-05 / 1.704949565638429e-05 0.002721 3
285 ATF7IP2_5 0.0000000000 0.0032839512279112418 / 0.002993599664223763 / 0.002476029139206104 8.537589066325822e-06 / 2.5436790588774414e-05 / 5.142377607346069e-07 0.002918 3
286 S100A10_1 0.0000008705 0.0030838618137353662 / 0.0016555906467057811 / 0.004531342266561176 1.1613890918983097e-06 / 1.6946838169885616e-05 / 9.665990417390237e-05 0.00309 3
287 TRIP6_1 0.0000002147 6.392429369799613e-05 / 0.008158453075892491 / 0.0012146763275784356 3.2750776669883485e-08 / 4.272773668654882e-07 / 5.404314030094148e-07 0.003146 3
288 EIF3J_2 0.0000000002 0.005021029517387429 / 0.004594623942981826 / 0.0005725315156474846 1.0666101484276558e-06 / 8.707499404147844e-06 / 7.206761532626187e-07 0.003396 3
289 CASP4_1 0.0000000780 0.008158453075892491 / 0.0012146763275784356 / 0.0011036487237694873 2.347967797408527e-08 / 1.0559189019803553e-06 / 3.278522050115709e-06 0.003492 3
290 NSL1_2 0.0000000033 5.3340489000579145e-05 / 0.011092727550841517 / 5.792866128396694e-05 2.2018205271807595e-07 / 0.00024742638651566884 / 3.7695931576460654e-06 0.003735 3
291 VASP_1 0.0000006404 0.009220967328515883 / 0.00029139375190295606 / 0.002271551295087959 1.683199820716066e-07 / 2.799847052848426e-07 / 5.915001438135837e-07 0.003928 3
292 COG2_3 0.0000000010 0.012184597869329615 / 0.00017818061059800717 / 3.3817330366409276e-05 9.88977547194958e-07 / 9.135799923405938e-08 / 3.6569660447432056e-05 0.004132 3
293 STMN4_3 0.0000000000 2.061341498862413e-06 / 0.013557269953071502 / 0.00016739297171412964 1.1827971870760236e-07 / 1.7028450668349932e-05 / 2.2310679101285705e-05 0.004576 3
294 ARID2_1 0.0000005167 0.009220967328515883 / 0.00029139375190295606 / 0.004557941079021841 2.2639222896451386e-07 / 1.109801352982852e-06 / 2.1017914639263102e-07 0.00469 3
295 TMEM145_2 0.0000000541 0.011857375508327873 / 0.0019384937218085618 / 0.0003086352962437011 3.703004816743222e-08 / 9.472094543228691e-06 / 3.7868771404399016e-07 0.004702 3
296 RPS28_2 0.0000000062 0.0013196713645063731 / 0.00015680243457987764 / 0.013122781516773055 2.4859140381808595e-07 / 8.661018242204261e-07 / 1.0278447900767023e-05 0.004866 3
297 BHLHB9_5 0.0000000000 0.000833093052382085 / 0.0017373454847881562 / 0.012094762315019585 0.0003876834856951191 / 0.00025814098757798783 / 0.0012619942783536312 0.004888 3
298 CCT3_2 0.0000003320 0.0053229089046933666 / 0.0035672102749117456 / 0.006424879308109518 1.385234000351963e-09 / 1.1973928792856672e-07 / 8.271151178245213e-07 0.005105 3
299 ZBTB39_1 0.0000012961 0.0002459835698877307 / 0.012131971219889692 / 0.003904810749383955 1.947682987909157e-09 / 4.769808257064375e-06 / 1.009907236026598e-05 0.005428 3
300 TGFBI_1 0.0000001859 0.014968932619439228 / 0.00029139375190295606 / 0.002271551295087959 8.323645474851572e-06 / 2.8646241152477385e-06 / 2.2007597669701546e-05 0.005844 3
301 DRAM1_2 0.0000000007 3.95395916749111e-05 / 0.005028962391482225 / 0.012655371032190181 7.334418459565927e-07 / 2.9757670605999017e-06 / 7.803574545937928e-05 0.005908 3
302 TTC9B_4 0.0000000010 3.2451983838054593e-06 / 0.0027782153739561613 / 0.015336438182107533 5.579389394627073e-06 / 2.6478455347372e-05 / 6.774767693632554e-05 0.006039 3
303 CRABP1_2 0.0000000000 0.00018053504491942103 / 0.0006013127917976173 / 0.017420025549877295 3.6420294337565723e-08 / 4.7891636027032046e-05 / 2.4547340474687967e-05 0.006067 3
304 PRNP_1 0.0000012041 0.008158453075892491 / 0.01165101001080378 / 0.0011036487237694873 1.1937594193840056e-07 / 3.852111240660634e-06 / 7.982699562459387e-07 0.006971 3
305 RNF216_2 0.0000000710 0.01978912870326623 / 0.0009038593586046481 / 0.001339659580920153 1.2928230810660568e-06 / 1.509161544583804e-07 / 3.464852330723318e-06 0.007344 3
306 KCNH2_1 0.0000005910 0.0011929519758551942 / 0.013144247549246738 / 0.007698641086675404 4.050881868723152e-06 / 5.993445368097023e-06 / 9.184683537215863e-05 0.007345 3
307 HDAC2_1 0.0000111884 0.0013546126949011356 / 0.015529327313804105 / 0.0060782790336966815 8.678070199327975e-10 / 9.165188556262711e-07 / 1.9640719268488575e-07 0.007654 3
308 LDLRAD3_2 0.0000000086 0.000790463498248653 / 0.022196441234578132 / 2.1369034750623554e-06 2.3758722136689975e-06 / 9.69193707515232e-05 / 3.165236790324336e-05 0.007663 3
309 DLG2_1 0.0000004953 9.390951294242489e-05 / 4.611763366846969e-05 / 0.023379270483941148 1.6435897498809227e-05 / 8.947838561493191e-07 / 0.0005491970493346228 0.00784 3
310 ABHD2_2 0.0000007167 0.007702284030015268 / 0.015157007205383797 / 0.002098496534836373 6.150334665817541e-07 / 2.79918960850902e-06 / 1.3380586388949062e-06 0.008319 3
311 FICD_1 0.0000000879 0.00042879723237597764 / 0.003993715376548959 / 0.02118368053863915 2.9785947869700167e-06 / 6.873856442248643e-07 / 6.404598440436032e-07 0.008535 3
312 EML5_1 0.0000186293 0.0003816779304374477 / 0.007313973432554173 / 0.019582037452342965 1.768922156010669e-08 / 3.733774907814613e-07 / 8.463320131580384e-05 0.009093 3
313 ZNF280B_1 0.0000176080 0.0002021790532799894 / 0.012782548244800053 / 0.015382714940475899 4.16735367252946e-06 / 1.8932170047411166e-06 / 0.0006150439183333181 0.009456 3
314 MAST1_1 0.0000012460 0.0030838618137353662 / 0.0016555906467057811 / 0.02419315699804896 1.008321219643804e-08 / 6.59179220363995e-08 / 2.8729044379438386e-06 0.009644 3
315 NBR2_4 0.0000000013 0.0030139413806392025 / 0.02262700624929458 / 0.004062778899218961 2.6809213542125635e-07 / 3.3592733116787e-06 / 5.084507985309251e-05 0.009901 3
316 ZSCAN16_1 0.0000021993 0.009406629582018086 / 0.007054606953047138 / 0.013414705614259708 3.1919700086632823e-08 / 4.241176857088593e-06 / 1.10182899392691e-05 0.009959 3
317 CD109_1 0.0000004857 0.0030838618137353662 / 0.026132194840960694 / 0.0016555906467057811 4.1459663612593765e-07 / 1.133270373704853e-05 / 6.95591696890365e-07 0.010291 3
318 ASCL1_1 0.0000012961 8.712601577854501e-09 / 0.0014562282237067896 / 0.029987683740818265 6.622928776298776e-08 / 4.986303622240574e-07 / 5.121638955023879e-05 0.010481 3
319 PRCC_2 0.0000000009 0.02916029058932568 / 1.4053286193768942e-05 / 0.0033436620457161664 4.234540029087047e-09 / 7.396677617376084e-08 / 5.762915371340719e-06 0.010839 3
320 SYPL1_3 0.0000000001 0.0010868506221494473 / 0.03062224194622656 / 0.0008798790932645847 1.8036241827089262e-07 / 1.170707624311846e-06 / 8.621104111789159e-06 0.010863 3
321 CACNA1B_3 0.0000023253 0.0006313127973618962 / 0.026533133928238382 / 0.00548175365183452 4.657105147722875e-06 / 0.00011767035322254456 / 0.0009513496148143766 0.010882 3
322 FEV_3 0.0000000016 0.0018157417923330308 / 0.0005005652894286239 / 0.03138718307129687 5.9293955966041735e-08 / 1.9491788120934706e-06 / 3.089744526549523e-05 0.011234 3
323 VSTM2A_2 0.0000000860 0.000506059688566897 / 0.02830343719752466 / 0.005186853257558283 4.451709831952587e-07 / 0.0006571117480683702 / 0.0019723456239841616 0.011332 3
324 DOC2A_1 0.0000176432 0.00025234279143195943 / 0.005397134900618702 / 0.028677370706029427 2.097886384356248e-06 / 4.3459478389049724e-07 / 7.808876942721705e-07 0.011442 3
325 MTR_1 0.0000001011 9.388757698010748e-05 / 0.015063580358728427 / 0.020113164514031456 2.0462926382898192e-05 / 2.0838053089232e-06 / 0.0006005512194214275 0.011757 3
326 TMEM184B_1 0.0000052583 0.017443397981769932 / 0.002318126437551203 / 0.017145541610166553 5.074118788922354e-08 / 1.528139375785279e-07 / 1.361457730245486e-06 0.012302 3
327 ARID2_3 0.0000002768 0.005599828148522198 / 0.014996743361982036 / 0.018170592466726792 9.116542240665922e-09 / 1.5456378377669386e-06 / 4.750875211998681e-06 0.012922 3
328 TSEN54_2 0.0000000000 0.00021036438824558563 / 0.0016249672415913465 / 0.03836197892479358 1.419950215795548e-07 / 1.6203351133132878e-07 / 1.5720016310468745e-05 0.013399 3
329 LAMP2_1 0.0000061826 0.0006291978832262494 / 0.017133475216302412 / 0.02253012830344572 2.3046914608799517e-06 / 5.662655646886999e-07 / 4.09648566039462e-06 0.013431 3
330 GPX8_1 0.0000006021 0.007054606953047138 / 0.009406629582018086 / 0.024046868563271137 7.3135246584530174e-09 / 6.656311691714102e-10 / 6.25392798502714e-06 0.013503 3
331 PRIM1_1 0.0000003223 0.0019943829025712437 / 0.032332967518234994 / 0.006230194892575304 7.867184240616801e-06 / 5.037758463198267e-08 / 2.7703126525457583e-06 0.013519 3
332 MMD_3 0.0000000000 0.00026462416519984375 / 0.04009931021218081 / 0.0018585225095028022 3.265086074696618e-08 / 3.8983782729439324e-05 / 5.764266261871919e-06 0.014074 3
333 HSPD1_1 0.0000016837 0.029245906890336886 / 0.012044249045532097 / 0.0010265738076671066 3.4847461970373735e-08 / 5.585527560266155e-06 / 7.023185063013887e-06 0.014106 3
334 TNFRSF12A_5 0.0000000000 0.032768876151590194 / 0.009211796235391962 / 0.0006064986533695733 9.11501895060049e-06 / 1.6191708335697414e-05 / 3.563543914807607e-06 0.014196 3
335 PLP2_4 0.0000000002 0.043329534197300235 / 4.1971169891966186e-05 / 0.00011139453192955434 4.795701871201485e-07 / 3.953822199723069e-06 / 0.002463554449974249 0.014494 3
336 SNX3_1 0.0000004514 0.012469105184180684 / 0.009827915816152012 / 0.02176087444903759 1.575326562154422e-07 / 1.0953632726584286e-07 / 4.669480873853378e-06 0.014686 3
337 SMC3_1 0.0000067784 0.01903033340546255 / 0.025082579510674555 / 0.0002021790532799894 7.004137458574501e-07 / 7.700331048016097e-07 / 1.9353158268148655e-06 0.014772 3
338 ARHGAP1_1 0.0000026967 0.017145541610166553 / 0.011413935706631708 / 0.017443397981769932 1.3146010474489681e-05 / 4.804751045086965e-06 / 2.132159178159428e-06 0.015334 3
339 LPP_1 0.0000033409 0.01487722458866696 / 0.0017052769733922298 / 0.02985182122259529 1.546223090931648e-07 / 4.2508307877523196e-08 / 1.4414883845347043e-06 0.015478 3
340 MGAT1_1 0.0000004092 0.014660785392642973 / 0.017145541610166553 / 0.017443397981769932 1.7966684116150096e-06 / 5.116593940505276e-06 / 1.3410770868177782e-06 0.016417 3
341 TNFRSF1A_3 0.0000000002 0.0028067534068265437 / 0.00042105945887903654 / 0.048060814464615735 1.0121421064420374e-05 / 7.452615942617135e-06 / 9.353097000119014e-05 0.017096 3
342 C12orf10_1 0.0000001344 0.01695446499444467 / 0.014675290351873422 / 0.02095078822868191 9.883275335709048e-07 / 3.3979035604139886e-07 / 1.4183511170080205e-05 0.017527 3
343 KLF15_1 0.0000009834 0.02839442496647524 / 0.011495528751480646 / 0.017748059549662194 2.539351518692909e-07 / 3.996180547635244e-06 / 3.72884546184977e-07 0.019213 3
344 RSL1D1_1 0.0000024224 0.029245906890336886 / 0.029072859932669184 / 0.001209619547547507 1.928466390137773e-09 / 1.7774626241888566e-05 / 2.7621925072470266e-06 0.019843 3
345 CDK2AP2_1 0.0000069090 0.03413875749258289 / 0.008813705248904322 / 0.017145541610166553 7.980991943354118e-06 / 9.182341905056802e-07 / 6.046703803974713e-06 0.020033 3
346 ENOX1_1 0.0000096565 0.017443397981769932 / 0.03683753470884825 / 0.008813705248904322 8.46495419886903e-08 / 2.477238173018046e-06 / 5.706880115624909e-06 0.021032 3
347 KLHL36_1 0.0000009988 0.017443397981769932 / 0.03683753470884825 / 0.008813705248904322 8.55516827501211e-06 / 5.0553384219596765e-06 / 3.3892208678789174e-05 0.021032 3
348 C1R_1 0.0000103261 0.017443397981769932 / 0.011413935706631708 / 0.03683753470884825 5.223576944443697e-10 / 1.278142542397936e-07 / 9.066430827258057e-08 0.021898 3
349 DLL3_1 0.0000022545 0.017443397981769932 / 0.011413935706631708 / 0.03683753470884825 2.879808838966571e-07 / 6.993476243540988e-06 / 7.726331259366366e-07 0.021898 3
350 NPC1_1 0.0000013000 0.023996288711547777 / 0.014582218475483697 / 0.027344357279935363 5.764157631131607e-07 / 2.4200174195178475e-06 / 8.775983171046948e-07 0.021974 3
351 BPTF_1 0.0000012059 0.0010265738076671066 / 0.029245906890336886 / 0.039756863847419444 2.75081594060756e-06 / 1.849240931697844e-06 / 9.833875885810182e-05 0.023343 3
352 CCNB1IP1_1 0.0000010768 0.029245906890336886 / 0.0010265738076671066 / 0.039756863847419444 5.5727604077632575e-08 / 1.0079899592111368e-06 / 6.245632688934216e-06 0.023343 3
353 NPC2_1 0.0000110270 0.03683753470884825 / 0.017443397981769932 / 0.017145541610166553 2.895916979465306e-07 / 4.350257929933473e-06 / 5.881485803416461e-06 0.023809 3
354 ABAT_3 0.0000000001 0.034052040127872246 / 0.006551644901500213 / 0.03343958590730531 4.991017761660758e-05 / 1.6284836400790797e-06 / 5.991633249924668e-06 0.024681 3
355 CEP170_3 0.0000000001 2.3886446874268867e-06 / 3.5555136352418323e-06 8.64144400156011e-07 / 9.9452244969615e-06 2.97E-06 2
356 NUCB1_3 0.0000000000 9.120027832512087e-06 / 4.9060208885387406e-06 4.76082633817649e-08 / 1.542543895417389e-06 7.01E-06 2
357 LAMP1_5 0.0000000000 7.561570077756679e-06 / 7.75081771574093e-06 1.0518690072819026e-09 / 7.017816798332179e-06 7.66E-06 2
358 MAP4_2 0.0000000001 2.1541055929197527e-08 / 1.9308695609987287e-05 3.93734689573353e-09 / 7.038983428807821e-07 9.67E-06 2
359 MSH6_1 0.0000000525 2.098169823270148e-06 / 1.7711409436331332e-05 2.9237170575647894e-07 / 3.223701677601978e-06 9.9E-06 2
360 NECAP2_5 0.0000000000 1.1734627356832365e-05 / 1.4727302282280241e-05 6.34621052304883e-05 / 9.263010355358496e-05 1.32E-05 2
361 RFX7_1 0.0000006461 1.8023978844296698e-06 / 3.772462305351297e-05 1.3777889602205754e-05 / 5.134420163197374e-06 1.98E-05 2
362 LOXL1_1 0.0000000613 8.712601577854501e-09 / 4.778480179883678e-05 3.7451852636473064e-09 / 3.520223337931936e-07 2.39E-05 2
363 RAB11FIP5_1 0.0000003435 8.712601577854501e-09 / 4.778480179883678e-05 8.30614778438761e-09 / 1.875106499909923e-05 2.39E-05 2
364 SYNC_1 0.0000000544 8.712601577854501e-09 / 4.778480179883678e-05 1.8300368947275955e-09 / 1.1156949187536687e-06 2.39E-05 2
365 MYT1_2 0.0000000000 4.852661376064752e-06 / 5.1682368391364916e-05 6.5288974923630765e-06 / 2.33136261456977e-05 2.83E-05 2
366 CNTNAP2_4 0.0000000000 1.9536120969160626e-05 / 4.855499097832519e-05 2.69621468363523e-05 / 0.0005954550144190784 3.4E-05 2
367 SMARCA5_4 0.0000000000 3.104247296762117e-05 / 4.761108954152855e-05 1.84536023077791e-05 / 3.4952774168035884e-05 3.93E-05 2
368 B3GNT9_4 0.0000000000 4.759424034644978e-06 / 0.00012294606259085342 1.6260769696128954e-06 / 0.00010634285087971367 6.39E-05 2
369 GAL_2 0.0000000005 1.1566938688714122e-08 / 0.0001375276427082929 1.8119993137342534e-06 / 0.0013149790281325572 6.88E-05 2
370 TRIM56_5 0.0000000000 0.00014260412953936538 / 2.3479938806380944e-08 3.859067457796533e-06 / 3.656262715818669e-07 7.13E-05 2
371 CRIM1_3 0.0000000004 4.8106808740888186e-05 / 0.00010014977875691996 9.846475238177379e-06 / 5.579017068717648e-08 7.41E-05 2
372 PNMA3_5 0.0000000000 1.701692255505357e-06 / 0.00014830625115725305 2.0336906370795427e-06 / 9.840133053947521e-06 7.5E-05 2
373 HIST3H2A_3 0.0000000000 7.513947614807362e-05 / 0.00011429921060857062 1.068586509856438e-06 / 3.0653385085725396e-07 9.47E-05 2
374 ATCAY_5 0.0000000000 5.4278236645845715e-06 / 0.00020534480614177087 7.732934718383503e-06 / 2.75413488861665e-05 0.000105 2
375 SMARCA4_2 0.0000000016 2.321730111153503e-06 / 0.00022187513044902743 2.120449751487153e-08 / 3.5992692804583596e-05 0.000112 2
376 LIN28B_2 0.0000000000 1.216331498209144e-06 / 0.00029774828278028234 1.1201154484621356e-09 / 7.926073637103903e-06 0.000149 2
377 OLFML2A_5 0.0000000000 8.951974512115386e-05 / 0.00034027362168927155 9.130549898240117e-07 / 2.4504382448983827e-06 0.000215 2
378 ACP1_5 0.0000000000 6.364279791640112e-06 / 0.0004408162010949017 1.6688642528792083e-06 / 1.8017876923145952e-05 0.000224 2
379 ACTL6B_3 0.0000000040 0.0003057625951752015 / 0.00015450477319284894 1.060226377821344e-06 / 2.1353909002247907e-05 0.00023 2
380 PHF21B_4 0.0000000000 7.623480320281502e-07 / 0.0004987725781895633 5.2768179043587e-06 / 1.09188294232324e-06 0.00025 2
381 BAZ1A_1 0.0000069836 0.00064922210107833 / 1.8023978844296698e-06 1.6595910049899672e-07 / 4.925632831272468e-06 0.000326 2
382 TMEM30A_1 0.0000022161 0.0006240411433431414 / 5.2470753247363745e-05 3.5429731576541734e-08 / 5.5462823621098335e-08 0.000338 2
383 NOL11_2 0.0000000000 0.00046464339325169037 / 0.0002564595505663515 5.933716019020396e-07 / 7.456072877479674e-09 0.000361 2
384 BEND4_5 0.0000000000 1.5777685999047575e-06 / 0.0007208108997517884 5.3901186417921756e-11 / 2.815995740727121e-07 0.000361 2
385 ELOVL1_3 0.0000000020 0.0006923847970197059 / 3.196763725059841e-05 2.677497381339075e-07 / 0.00021491113805745135 0.000362 2
386 PFKM_4 0.0000000000 0.0007309049115603717 / 8.501642925216299e-06 9.403882200312194e-08 / 7.819007418155511e-07 0.00037 2
387 NMNAT1_2 0.0000000129 0.0004526675305989492 / 0.0003016808649104736 9.397755887797147e-06 / 0.00010313370779319529 0.000377 2
388 TIGD1_2 0.0000000029 0.00015234942199771114 / 0.000651352109304205 8.064616695114456e-07 / 4.491126688099632e-05 0.000402 2
389 ARL1_5 0.0000000000 1.694043434756899e-05 / 0.0008334490663588983 2.2314679547176197e-07 / 4.126172052886268e-06 0.000425 2
390 CPLX1_4 0.0000000002 0.0008665554418518524 / 5.737321179382452e-06 5.87667964571385e-06 / 3.438314234654185e-05 0.000436 2
391 PAX6_5 0.0000000000 0.00027854752254638905 / 0.0006006286848231235 1.3031733956534446e-07 / 2.2950534119176534e-06 0.00044 2
392 ANXA2_5 0.0000000000 0.00022245643971115814 / 0.0008228851369949542 0.0002774948155360362 / 4.3531858337072534e-05 0.000523 2
393 BHLHE41_1 0.0000003123 3.679473658399758e-05 / 0.0010281262291342236 5.186786515718226e-05 / 4.276807002378442e-05 0.000532 2
394 DPYSL5_2 0.0000000245 0.0005017064663366604 / 0.0006658727095010238 1.0246351818305243e-08 / 2.9985183250414335e-08 0.000584 2
395 NCL_5 0.0000000000 0.0001902762125730563 / 0.0010196091469089486 1.1394612086185451e-07 / 5.477181895031346e-05 0.000605 2
396 NEK6_3 0.0000000000 0.00042892841962168427 / 0.0007955623084328148 4.625637105430227e-06 / 1.9802846632838944e-05 0.000612 2
397 ADAM11_1 0.0000014021 0.00020676489909411184 / 0.0010623957357494855 6.162977005662482e-06 / 1.5065356540452738e-05 0.000635 2
398 BMP1_1 0.0000001479 8.712601577854501e-09 / 0.0014562282237067896 1.0629725087716493e-09 / 3.3335712676585927e-10 0.000728 2
399 CRABP1_1 0.0000012003 8.712601577854501e-09 / 0.0014562282237067896 1.0032588981222376e-06 / 1.6633089557898398e-05 0.000728 2
400 CREB3_1 0.0000002396 8.712601577854501e-09 / 0.0014562282237067896 3.248193062600497e-07 / 1.8160839243636814e-05 0.000728 2
401 CTSB_1 0.0000004048 0.0014562282237067896 / 8.712601577854501e-09 2.7850840733739764e-08 / 6.154886102926167e-07 0.000728 2
402 GLB1_1 0.0000009020 0.0014562282237067896 / 8.712601577854501e-09 5.1549922184344e-09 / 2.2049835157073303e-11 0.000728 2
403 LGALS3_1 0.0000001910 0.0014562282237067896 / 8.712601577854501e-09 3.755610443792837e-07 / 1.150827659828279e-08 0.000728 2
404 SMPD1_1 0.0000000902 8.712601577854501e-09 / 0.0014562282237067896 1.2661160783158677e-07 / 1.5916398320881086e-06 0.000728 2
405 GTPBP4_1 0.0000001295 0.00028286232014178015 / 0.001443320215490813 1.1507531465572511e-05 / 8.380217354744253e-07 0.000863 2
406 ACTR3B_2 0.0000000074 0.00014435842640211195 / 0.0016167318511468814 3.4516372751432266e-05 / 1.6235896245152234e-05 0.000881 2
407 CSRP1_3 0.0000000000 0.0008963909784287442 / 0.0008703935843289303 1.2552190959143249e-05 / 1.0273857961970511e-05 0.000883 2
408 SEPHS1_1 0.0000001827 0.00173044075017522 / 3.679473658399758e-05 8.824502672922857e-06 / 3.0791704702592284e-05 0.000884 2
409 ACTN2_1 0.0000008238 0.0011231690936696782 / 0.0006456808009902826 1.5971362873791044e-06 / 1.6414697658368195e-07 0.000884 2
410 NMRK1_2 0.0000000009 7.927156138657951e-05 / 0.0016947048583457857 1.3825176406826697e-06 / 3.53470906662037e-07 0.000887 2
411 TFAP2A_1 0.0000010622 0.000397182645222389 / 0.001498796467852237 1.6591165825267682e-05 / 3.1676679082128444e-06 0.000948 2
412 CAV1_3 0.0000000000 0.0017923927195771076 / 0.0001624925597934157 1.6411382731391108e-05 / 7.945990872997567e-06 0.000977 2
413 PQLC3_2 0.0000004701 4.389629454841824e-05 / 0.001937287334836558 1.0375195933235037e-08 / 2.8078868409381863e-06 0.000991 2
414 RPL9_4 0.0000000000 3.781374276352481e-05 / 0.002265806028844651 2.8562585574590404e-07 / 1.520546898812959e-06 0.001152 2
415 H2AFY2_3 0.0000000000 0.0023614039163946366 / 5.479642713695821e-06 9.720407948559726e-06 / 2.5274722144655105e-05 0.001183 2
416 MCM10_1 0.0000038124 0.0021610939865988614 / 0.0004600723635955347 1.9111116053257913e-05 / 1.8478236194529347e-06 0.001311 2
417 G6PD_1 0.0000098647 0.0023157697041580965 / 0.0006256240573576323 2.857433835593977e-06 / 2.3724383307219822e-05 0.001471 2
418 TADA1_1 0.0000012097 0.0026490796375761676 / 0.0004052971561229435 3.531944691795736e-06 / 1.881582874926359e-06 0.001527 2
419 KCNC1_5 0.0000000000 1.8731875907040327e-05 / 0.0031223581236072607 7.480602345183493e-06 / 9.900952757251972e-06 0.001571 2
420 JPH4_1 0.0000020704 0.00037839447623271325 / 0.0028279669089626516 1.0663281519153872e-06 / 5.068294298254466e-05 0.001603 2
421 ZNF121_3 0.0000000002 2.4284932942339803e-06 / 0.0032468305940381815 1.097169523033381e-06 / 1.0244293507613468e-05 0.001625 2
422 TMEM206_1 0.0000001917 0.002859168680149655 / 0.0007069744136606002 4.159808093795964e-07 / 7.162200636393188e-06 0.001783 2
423 HS3ST4_1 0.0000030972 0.0027568341257606386 / 0.0008433274564043463 5.152072021912856e-05 / 0.00013189356327001007 0.0018 2
424 MRPL48_1 0.0000003952 0.0037409240031547972 / 1.2412020538304333e-05 0.00010762773346764832 / 5.800656513229227e-07 0.001877 2
425 PPAT_5 0.0000000000 0.0005240883442637788 / 0.0033630327163844836 1.3405009998715396e-07 / 2.0737516222338193e-07 0.001944 2
426 CELF3_3 0.0000000012 2.6606264463249574e-05 / 0.004048158047358375 1.681108063763094e-07 / 6.662779385674438e-06 0.002037 2
427 ABCC8_1 0.0000123268 0.0005728902408745853 / 0.0037587720790259365 2.6233964453337422e-05 / 0.007471621864095462 0.002166 2
428 KIF1C_4 0.0000000003 0.0032619641963901502 / 0.0011569950059438523 8.154868752547337e-07 / 2.557520533005861e-06 0.002209 2
429 MOSPD2_1 0.0000012002 7.763485144629643e-05 / 0.004557941079021841 7.941462431738191e-07 / 1.6722356038590327e-05 0.002318 2
430 ANKRD46_1 0.0000009529 0.0016555906467057811 / 0.0030838618137353662 3.117928478396429e-07 / 1.2106488464901888e-06 0.00237 2
431 RSL24D1_1 0.0000003735 0.0020456136275657888 / 0.002859168680149655 5.740933296039192e-08 / 6.94594888585274e-07 0.002452 2
432 HNRNPC_1 0.0000000442 0.0003168019030192227 / 0.004613449756294485 1.5683726426363387e-05 / 3.1384990249702817e-06 0.002465 2
433 LYST_1 0.0000015802 0.004613449756294485 / 0.0003168019030192227 1.6458786012670833e-07 / 2.821962785745458e-08 0.002465 2
434 MRPS31_2 0.0000000065 0.004772335371973973 / 0.0003355045145354899 3.3355235309279226e-06 / 9.633635724889396e-07 0.002554 2
435 ANXA11_1 0.0000056530 0.005164155170869671 / 0.0004491267996311823 2.916507287390681e-05 / 2.0269807072431288e-06 0.002807 2
436 GABRB3_2 0.0000003351 0.000506059688566897 / 0.005186853257558283 3.096339568332632e-07 / 8.425728705562362e-05 0.002846 2
437 ITGB5_4 0.0000000000 9.326256093187905e-05 / 0.005791631747081949 4.1150806272283625e-06 / 3.579067579944918e-06 0.002942 2
438 TAGLN_5 0.0000000000 0.0016087657150710478 / 0.004695933649935298 1.0747776301357894e-06 / 5.068277336951496e-07 0.003152 2
439 KLF6_1 0.0000063009 0.000825624209859881 / 0.005675752403043091 1.566826366040112e-06 / 2.0575603093756347e-05 0.003251 2
440 GLIS3_1 0.0000001584 0.0019027179320774803 / 0.004613449756294485 8.91146182579548e-08 / 1.1981910549231142e-05 0.003258 2
441 GRPEL2_3 0.0000000000 0.00010726957614676581 / 0.006720367764597034 4.439257342558768e-06 / 8.438825442463246e-05 0.003414 2
442 SORCS1_2 0.0000000000 8.208006168567451e-05 / 0.007038129780933908 7.728334683674074e-07 / 5.209097425595317e-05 0.00356 2
443 TAF3_1 0.0000099483 0.0013546126949011356 / 0.0060782790336966815 1.1902144022027374e-07 / 3.590125727174815e-07 0.003716 2
444 ZNF638_4 0.0000000002 0.004643194113383492 / 0.002879683794588439 1.1731748076272809e-07 / 2.1004419064549084e-06 0.003761 2
445 RPAIN_2 0.0000000089 0.005656902703414097 / 0.0020182027192515075 3.683542119198933e-06 / 5.1931234206185375e-06 0.003838 2
446 PRMT6_2 0.0000000762 4.9232228985570196e-05 / 0.007808321395428832 8.633725399474921e-08 / 1.0594310607660115e-06 0.003929 2
447 CERCAM_1 0.0000000458 0.007033451966587178 / 0.0011697552308872906 2.6140734636276835e-07 / 3.3435498079309047e-05 0.004102 2
448 TWSG1_1 0.0000001761 6.392429369799613e-05 / 0.008158453075892491 5.157744855455523e-08 / 1.1607198631441237e-05 0.004111 2
449 NAP1L1_1 0.0000006251 0.0009903851658940631 / 0.00741156873832107 3.573144437875835e-08 / 2.6755598797458433e-05 0.004201 2
450 NQO2_1 0.0000003120 0.008488814061362355 / 9.017693290134859e-06 2.7731541539595674e-05 / 2.8873360375852757e-06 0.004249 2
451 EXOSC5_1 0.0000025109 0.0004974933526793384 / 0.008173144283430401 7.804789577957665e-13 / 7.74266535906266e-08 0.004335 2
452 LTBP2_1 0.0000549802 0.0001478074168080298 / 0.008876460493888159 0.00010798007651110131 / 4.222343931835182e-06 0.004512 2
453 KIAA1549_3 0.0001342161 0.0026287641054243034 / 0.006519007047359032 7.168411667949609e-07 / 5.5430987684595595e-06 0.004574 2
454 LRP10_2 0.0000001825 0.005921869111264299 / 0.003413606680030668 2.207361096450598e-08 / 3.3470759617279554e-06 0.004668 2
455 CIB1_4 0.0000000168 0.009433179531708233 / 3.3215427791608696e-05 4.2846313000380545e-08 / 3.7292417647649567e-07 0.004733 2
456 RPL19_1 0.0000014928 0.009179325672229992 / 0.00029389877591584477 7.496923788892963e-09 / 2.8239822943662147e-07 0.004737 2
457 CBX2_2 0.0000000000 4.7075406338787466e-05 / 0.00976885548005096 4.131142779946589e-09 / 5.375769141126671e-07 0.004908 2
458 CLVS2_2 0.0000001913 0.009406082212144616 / 0.0006563295421036791 2.5714332068383276e-06 / 5.482716962081155e-06 0.005031 2
459 GLIPR1_2 0.0000000000 3.466171778138515e-05 / 0.010368022895379076 5.654483400792844e-07 / 5.55002977254214e-06 0.005201 2
460 TAPBP_3 0.0000000000 8.512267986732582e-07 / 0.011323761387770928 4.890820513972833e-08 / 6.67431019433855e-06 0.005662 2
461 GNA12_3 0.0000000000 0.001517583413099564 / 0.009900066282835398 6.708969086365922e-07 / 9.569962786694717e-06 0.005709 2
462 MBNL1_1 0.0000001024 0.002859168680149655 / 0.008597087236259153 2.975015241938413e-06 / 0.00015116218032026587 0.005728 2
463 ISYNA1_2 0.0000000015 0.005657495944434386 / 0.006635836004693275 6.464027654347149e-08 / 2.887101958288562e-06 0.006147 2
464 PRLHR_2 0.0000005406 0.007129272200886299 / 0.0052714519884625305 7.77168866368208e-06 / 1.8437240853929896e-05 0.0062 2
465 IQGAP1_5 0.0000000000 0.012455997462084369 / 1.7523681094523592e-05 1.1619283901710663e-08 / 3.139400513751516e-09 0.006237 2
466 SDC4_2 0.0000000000 3.95395916749111e-05 / 0.012655371032190181 4.7350612738275925e-07 / 4.772494328825351e-05 0.006347 2
467 NAA25_1 0.0000047407 0.0004974933526793384 / 0.012491622786737646 8.408015879409482e-10 / 1.1193839755975793e-07 0.006495 2
468 PLEKHA4_1 0.0000000554 0.012681018200430948 / 0.0008147104901488364 4.9420107205779745e-08 / 0.00013683562427249123 0.006748 2
469 TUBA4A_2 0.0000001526 0.0004894051617618149 / 0.013748845190012026 7.439143899721087e-06 / 5.6974125969133664e-05 0.007119 2
470 SLC35D1_1 0.0000119741 0.0011586570434241133 / 0.01344459083967992 7.589908369304536e-05 / 2.286469998615828e-06 0.007302 2
471 SH3GLB1_1 0.0000007167 0.005409509534570436 / 0.00920357999307954 2.215338831755982e-08 / 9.144219102907184e-05 0.007307 2
472 RPL37_1 0.0000002993 0.00029139375190295606 / 0.014437131210731376 1.5481316880518014e-06 / 1.2695577765486368e-06 0.007364 2
473 KDELR3_3 0.0000009988 0.005599828148522198 / 0.009406629582018086 3.321175066033386e-08 / 1.7651037681600008e-10 0.007503 2
474 DDX60L_1 0.0000004277 0.014968932619439228 / 0.00029139375190295606 3.349293334251501e-05 / 3.67192886950216e-06 0.00763 2
475 GNPDA2_1 0.0000009111 0.012345925407573809 / 0.0029871868526872383 1.0139345130923212e-06 / 7.401416660830965e-06 0.007667 2
476 DPY30_1 0.0000001493 0.01474377883043126 / 0.0008872221356225374 8.242352750056853e-06 / 1.0099284699945813e-06 0.007816 2
477 MURC_2 0.0000010524 0.002464237492576691 / 0.013298076855589635 0.00016259523386897824 / 1.28646138088586e-05 0.007881 2
478 CCDC80_2 0.0000000780 0.007022396430063894 / 0.009406629582018086 1.9897144922152364e-08 / 5.96038844248789e-08 0.008215 2
479 C12orf23_1 0.0000007686 0.007054606953047138 / 0.009406629582018086 2.070000126404187e-09 / 3.064830496384329e-08 0.008231 2
480 LOX_1 0.0000004721 0.007054606953047138 / 0.009406629582018086 5.585615326605659e-08 / 2.025993050202001e-07 0.008231 2
481 CEP68_3 0.0000000000 0.014160855902587557 / 0.0025428536177246916 6.659688421576734e-07 / 9.407794731883787e-07 0.008352 2
482 BEND3_1 0.0000004060 0.015529327313804105 / 0.0013546126949011356 1.294856510154241e-07 / 7.843354585243828e-07 0.008442 2
483 RPRD2_3 0.0000001192 0.0042160036963409305 / 0.013951484913323634 3.745187782499438e-06 / 6.105707567166931e-05 0.009084 2
484 ELAVL4_3 0.0000000002 0.006262584938725883 / 0.012965192074116545 1.9990927267649097e-08 / 1.2028673633713268e-05 0.009614 2
485 TRIM21_1 0.0000010287 0.010532112594999697 / 0.00986299981987636 5.27087064977811e-07 / 1.4605266535016458e-05 0.010198 2
486 PRPF40B_1 0.0000427258 0.017494900781073297 / 0.0030164053071970965 1.5471503143081632e-06 / 5.832024795399863e-07 0.010256 2
487 DCLRE1A_1 0.0000061634 0.004458350846430188 / 0.0169361079209336 1.1237015427476724e-07 / 3.0864109406370913e-05 0.010697 2
488 DUSP12_1 0.0000017501 0.0005152101842532016 / 0.020927835765182444 1.3639586195049048e-06 / 3.496306255304265e-05 0.010722 2
489 TFPI_2 0.0000000132 4.6545402569552315e-05 / 0.02149290799813975 4.887360747506771e-06 / 4.0474405834306e-05 0.01077 2
490 MYO1C_2 0.0000000121 0.017895823171364 / 0.006230846374778002 3.081448301668384e-05 / 4.014555294520703e-06 0.012063 2
491 SYDE1_1 0.0000000110 0.00772762240557102 / 0.016780696985377475 1.1653781269953101e-07 / 3.463671891124625e-05 0.012254 2
492 RANBP1_1 0.0000003587 0.007033451966587178 / 0.018278644383879286 1.8768112225438676e-06 / 2.385161536231052e-05 0.012656 2
493 PRAME_3 0.0000000000 0.00027122572057250454 / 0.02549151253917823 7.315372425838117e-07 / 0.0043647330554926495 0.012881 2
494 PNN_1 0.0000004953 0.023632426585188764 / 0.0037180700854572363 1.567862197944385e-05 / 1.9432605539900083e-06 0.013675 2
495 PHF11_3 0.0000000000 0.0199742851386832 / 0.0074443763066621635 2.2460867352749832e-05 / 4.034050219148119e-05 0.013709 2
496 WDR35_1 0.0000956275 0.00595365839866055 / 0.022259394060437563 2.301536456666849e-08 / 4.7905231342002456e-05 0.014107 2
497 KCNN4_5 0.0000000000 0.028325850554739726 / 1.0422333032628909e-05 4.2230909676496135e-06 / 6.214193085118779e-08 0.014168 2
498 SERPINB6_1 0.0000000860 0.02111164899698619 / 0.007725328433277938 2.187431797229529e-06 / 2.509158352753995e-06 0.014418 2
499 ACOT9_5 0.0000000000 8.858145837069308e-06 / 0.02928133094687868 1.4274535341490866e-06 / 1.1707897663572821e-05 0.014645 2
500 LAMP1_2 0.0000000008 0.030054976866849478 / 8.732445306306717e-05 5.466481696938671e-06 / 1.5820496858297314e-06 0.015071 2
501 C19orf10_2 0.0000012073 0.007022396430063894 / 0.02370242637699958 1.3938096456595192e-06 / 3.106836436822797e-06 0.015362 2
502 EHD2_1 0.0000051889 0.006387086743044337 / 0.024359073362915318 3.1581541925072244e-08 / 6.252023917064675e-07 0.015373 2
503 DPH5_1 0.0000000253 0.005268014147815726 / 0.025798539904455884 7.65363618891567e-06 / 2.5443259723878794e-07 0.015533 2
504 TMEM169_1 0.0000042184 0.015328857071669418 / 0.01613036709497828 5.271735025959501e-06 / 7.657861944466996e-06 0.01573 2
505 SMARCB1_1 0.0000002644 0.02077959376727299 / 0.011174729900658115 8.011755580473669e-08 / 3.2615951234563365e-06 0.015977 2
506 PLEKHF2_1 0.0000084591 0.030555512760793904 / 0.0019120019643383967 6.139203454059454e-06 / 1.7597453128430795e-05 0.016234 2
507 HSF2_5 0.0000000024 0.0011883468549077506 / 0.032054869676694284 3.40227203271683e-05 / 0.00014757007119292403 0.016622 2
508 ASPH_1 0.0000002995 0.033538144332397844 / 0.00028614552404424633 5.685936788307393e-09 / 9.429685991450496e-08 0.016912 2
509 SERINC3_1 0.0000008790 0.033538144332397844 / 0.00028614552404424633 2.49764511508294e-09 / 1.134358362342082e-07 0.016912 2
510 THOC5_1 0.0000003036 0.013135303284974763 / 0.02077959376727299 2.342665333258182e-05 / 2.6803490912759556e-06 0.016957 2
511 SLC6A15_1 0.0000005833 0.004726766888964287 / 0.029245906890336886 3.0205657665658226e-07 / 1.9753690366539358e-07 0.016986 2
512 TBC1D2_1 0.0000051878 0.0026971498523362084 / 0.03142306493318558 2.36394903321324e-07 / 3.4669139065625866e-06 0.01706 2
513 HSPG2_1 0.0000035348 0.005508211750735854 / 0.029004639226340192 3.456379747077034e-08 / 1.3650260422668218e-06 0.017256 2
514 CACNA2D2_1 0.0000002397 0.012989035651382866 / 0.0220527090420233 9.84795387151116e-07 / 0.00014763731434387815 0.017521 2
515 SLC5A6_2 0.0000000011 6.726351690377188e-06 / 0.03632726905839838 3.564147772687014e-09 / 2.3833706506813445e-08 0.018167 2
516 DAZAP1_2 0.0000010886 0.035346052334371256 / 0.0020041144974840427 6.336641396851863e-06 / 2.7162116297049073e-06 0.018675 2
517 NFIX_2 0.0000470223 0.034278763403653136 / 0.004363119893312578 3.742274946692005e-08 / 8.621152000254767e-06 0.019321 2
518 ELAVL3_3 0.0000002367 0.032717168309564344 / 0.00603260340463039 5.233156358088248e-08 / 1.2259141243737108e-05 0.019375 2
519 COPB2_1 0.0000009988 0.030556265901493518 / 0.009461453275903385 7.7726596868819e-09 / 1.2483359571678263e-07 0.020009 2
520 ZNF219_1 0.0000201928 0.0013753510178836541 / 0.040351165135619635 4.130137554486895e-08 / 8.551025528226429e-06 0.020863 2
521 RNF165_2 0.0000000071 0.00045689445671322015 / 0.04290525645291146 4.007091987107082e-07 / 5.771520423008575e-06 0.021681 2
522 P4HA1_1 0.0000001230 0.03388354547402121 / 0.009805971532350915 0.0006317756731189806 / 1.426894913839978e-05 0.021845 2
523 CIB2_3 0.0000052976 0.03149060869705135 / 0.012259451329060318 9.024424890774902e-07 / 1.0442027429124592e-07 0.021875 2
524 LMAN2_1 0.0000170444 0.01903033340546255 / 0.025082579510674555 7.009613011978967e-07 / 2.5751189172533023e-06 0.022056 2
525 POFUT1_1 0.0000072701 0.001142587490178054 / 0.043241971329782115 7.112620349907573e-07 / 1.1322431164545276e-05 0.022192 2
526 ITGB1_1 0.0000003907 0.02269898054008244 / 0.0248532779265148 7.3505722166603895e-09 / 1.5385068037778083e-08 0.023776 2
527 GFPT2_2 0.0000000000 0.04814570015405706 / 9.938212812133593e-06 1.3739713879197712e-06 / 1.5888765178369776e-06 0.024078 2
528 SNTB2_2 0.0000013898 0.00045763370789409137 / 0.04798455655539519 4.937390910049744e-08 / 1.0481483686547674e-06 0.024221 2
529 FAM126A_1 0.0000076004 0.008114330308262623 / 0.043466125038867966 6.442446565574853e-07 / 7.404414626788326e-07 0.02579 2
530 FAM214B_1 0.0000010912 0.007767111012470563 / 0.04394971982153738 9.766150972459384e-09 / 5.811940190116354e-06 0.025858 2
531 E2F5_1 0.0000013604 0.049711930848541044 / 0.0033175174072552346 4.003267630664399e-07 / 9.866737749751602e-07 0.026515 2
532 CRMP1_1 0.0000084591 0.017443397981769932 / 0.03683753470884825 8.413742944743679e-07 / 4.106621117381678e-06 0.02714 2
533 DTX3L_1 0.0000084583 0.03683753470884825 / 0.017443397981769932 6.797147151581183e-07 / 1.417692420229351e-07 0.02714 2
534 ELAVL3_1 0.0000001607 0.03683753470884825 / 0.017443397981769932 1.3771030020123217e-07 / 1.1898412039254247e-06 0.02714 2
535 GATA2_1 0.0000032251 0.017443397981769932 / 0.03683753470884825 2.379056852862588e-07 / 7.419739232422929e-07 0.02714 2
536 GNG4_1 0.0000011175 0.017443397981769932 / 0.03683753470884825 2.833288980358075e-07 / 3.0194192839021757e-06 0.02714 2
537 GPX8_1 0.0000018792 0.017443397981769932 / 0.03683753470884825 1.1126780547850324e-07 / 3.7460365163269813e-07 0.02714 2
538 LATS2_1 0.0000002146 0.017443397981769932 / 0.03683753470884825 8.009574761254957e-07 / 7.564366651535585e-06 0.02714 2
539 TMEM87B_1 0.0000035381 0.046460374349346606 / 0.00986299981987636 2.2083608853369944e-06 / 2.6000415048116556e-06 0.028162 2
540 NR2C1_1 0.0000011174 0.049070601469191656 / 0.00773983756525658 1.016347019186649e-05 / 2.9570254790683987e-05 0.028405 2
541 CHMP4B_1 0.0000228401 0.023755415081211387 / 0.03496487724871062 7.568402263460558e-06 / 1.602695870510606e-06 0.02936 2
542 HPDL_1 0.0000326628 0.04277794935005184 / 0.01886546643390927 2.946919779060583e-07 / 2.526544471155658e-06 0.030822 2
543 HNRPDL_1 0.0000017461 0.029245906890336886 / 0.03496385796284249 5.094906510060717e-06 / 0.0005450663768553773 0.032105 2
544 MICB_1 0.0000005886 0.03856382315007413 / 0.030649533557856844 3.2225183304348016e-07 / 2.082657792499939e-05 0.034607 2
545 C17orf53_5 0.0056512849 0.03313812387988766 / 0.0369823965122664 1.7766971737416816e-07 / 4.945807676396787e-08 0.03506 2
546 WDR3_1 0.0000063135 0.038526552055961574 / 0.033508173499253606 1.3194741430704085e-06 / 5.999026130299875e-08 0.036017 2
547 FKBP15_1 0.0000015165 0.038665976753680685 / 0.037764618743349666 1.938771779561528e-07 / 8.867393316201706e-07 0.038215 2
548 SLC22A23_1 0.0000002831 8.712601577854501e-09 1.4395456175321122e-06 8.71E-09 1
549 ST6GALNAC3_1 0.0000002679 8.712601577854501e-09 1.7157900523441861e-07 8.71E-09 1
550 RCAN1_3 0.0000000016 3.499510929936492e-08 1.26835830581151e-07 3.5E-08 1
551 CCDC107_2 0.0000000001 6.395893878746714e-08 9.461935060607236e-07 6.4E-08 1
552 PAX6_2 0.0000000009 7.077258149360326e-07 9.972664897230697e-08 7.08E-07 1
553 IGSF9_5 0.0000000004 1.1979104163692412e-06 8.265188982147678e-06 1.2E-06 1
554 TFAP4_2 0.0000000085 2.321730111153503e-06 1.7564281952911052e-07 2.32E-06 1
555 B2M_5 0.0000000000 2.8861862169068284e-06 4.480381749486679e-06 2.89E-06 1
556 ZCCHC12_1 0.0000002526 3.027796588478565e-06 3.463674540195252e-08 3.03E-06 1
557 MYL12B_3 0.0000000860 3.036941140125125e-06 1.4602780290417217e-05 3.04E-06 1
558 SHPRH_5 0.0000000003 5.230619502812216e-06 2.937677082211747e-07 5.23E-06 1
559 NRSN1_4 0.0000000000 5.476196107524447e-06 2.997579133447394e-06 5.48E-06 1
560 HNRNPR_3 0.0000000000 5.558921390245165e-06 3.126649204411196e-06 5.56E-06 1
561 RRAGC_2 0.0000000001 5.618452957713235e-06 9.311046175034272e-06 5.62E-06 1
562 CTSA_3 0.0000000013 6.56608104779876e-06 2.506639438406534e-09 6.57E-06 1
563 DUSP26_3 0.0000000000 7.058822532691102e-06 4.827489564324781e-06 7.06E-06 1
564 IFI35_2 0.0000000001 7.334382821279422e-06 3.030479316814345e-07 7.33E-06 1
565 FAM163A_4 0.0000000000 9.356029087940393e-06 1.1664211635226015e-06 9.36E-06 1
566 DHX15_3 0.0000000002 9.568251410073365e-06 2.403428814770779e-07 9.57E-06 1
567 WDR86_3 0.0000000000 1.0462572531149967e-05 5.73499996685614e-06 1.05E-05 1
568 CECR5_1 0.0000003529 1.2412020538304333e-05 8.265652927676646e-07 1.24E-05 1
569 VASH2_1 0.0000000292 1.2412020538304333e-05 2.7260938912368544e-09 1.24E-05 1
570 KCNH8_2 0.0000000001 1.3893428326375037e-05 1.025651613746495e-06 1.39E-05 1
571 MRPS25_3 0.0000000000 1.4962982992013249e-05 5.883502199500679e-05 1.5E-05 1
572 COPS7B_4 0.0000000000 1.9055379659727616e-05 1.8406897134601384e-06 1.91E-05 1
573 PHYHIPL_2 0.0000000044 1.9765992682251932e-05 7.662073328952884e-08 1.98E-05 1
574 ATP6V0E1_3 0.0000000000 2.1199783161506686e-05 3.178350125115292e-06 2.12E-05 1
575 CEP44_5 0.0000000000 2.6817088180208884e-05 3.075797968981328e-07 2.68E-05 1
576 SEC22C_1 0.0000126263 3.772462305351297e-05 2.5473717020986836e-06 3.77E-05 1
577 TRIM38_2 0.0000000010 4.232307256197528e-05 9.004771302620853e-07 4.23E-05 1
578 MTF2_1 0.0000003729 4.778480179883678e-05 3.677618476819043e-06 4.78E-05 1
579 ZC3H15_4 0.0000000000 4.99139389651813e-05 8.062168588983905e-05 4.99E-05 1
580 THOC5_2 0.0000000078 5.370663550005663e-05 9.265177499664469e-07 5.37E-05 1
581 CLASP2_2 0.0000000009 5.412804644102036e-05 3.7830870595223054e-07 5.41E-05 1
582 SLC18A2_2 0.0000000045 5.6390218253045825e-05 1.7279928388791176e-05 5.64E-05 1
583 NDUFAF4_4 0.0000000000 5.8700155983793994e-05 2.5189349324309824e-08 5.87E-05 1
584 CHD4_1 0.0000002613 6.392429369799613e-05 4.5917357478734616e-10 6.39E-05 1
585 KIF5A_3 0.0000000388 6.823910763393263e-05 2.8021219460869213e-07 6.82E-05 1
586 CNN2_2 0.0000000049 7.667846295453872e-05 4.936771116007079e-06 7.67E-05 1
587 DCBLD1_2 0.0000000000 7.734573702217467e-05 2.622737549604328e-07 7.73E-05 1
588 SPSB4_2 0.0000000009 7.736803917574157e-05 1.665549189503519e-06 7.74E-05 1
589 EDIL3_1 0.0000003533 7.763485144629643e-05 2.106653942117265e-06 7.76E-05 1
590 GALNT10_3 0.0000000000 8.677918268232137e-05 8.482412543283543e-07 8.68E-05 1
591 H1FX_1 0.0000006013 9.000996792266372e-05 3.1636024561990265e-07 9E-05 1
592 OSGIN1_4 0.0000001415 9.283230157343638e-05 1.9657683205901488e-07 9.28E-05 1
593 PRRX1_1 0.0000004579 9.464090281065672e-05 3.3589212783746634e-09 9.46E-05 1
594 SERF2_1 0.0000008582 9.559019073817654e-05 3.4428228168417093e-07 9.56E-05 1
595 PPP1CC_3 0.0000000001 9.749181327114085e-05 1.7389165234639967e-07 9.75E-05 1
596 SYDE1_2 0.0000000598 0.00010643560926875712 1.503089017990499e-07 0.000106 1
597 C11orf74_2 0.0000000007 0.00010744642656817331 1.4631867053999944e-05 0.000107 1
598 NEFH_1 0.0000000473 0.00011095297992729127 1.5371136619548915e-05 0.000111 1
599 MPPE1_2 0.0000000746 0.00011144654065968228 1.6486688003824867e-06 0.000111 1
600 RAC3_1 0.0000011018 0.00012418009082273935 4.416840433956102e-05 0.000124 1
601 XRCC2_1 0.0000063155 0.0001281986995674009 2.3117725678541128e-08 0.000128 1
602 PVRL2_2 0.0000000002 0.00013157696997892983 1.9665782290909765e-07 0.000132 1
603 JAKMIP1_3 0.0000000000 0.0001624284911175795 1.3322851721010925e-05 0.000162 1
604 RETSAT_2 0.0000000021 0.00018285567959994966 2.2405276167100574e-05 0.000183 1
605 ECSIT_4 0.0000000000 0.00023954975788706846 7.566489045169451e-08 0.00024 1
606 KCTD11_5 0.0000000000 0.0002424331083574083 3.522356648205783e-06 0.000242 1
607 NOL4_1 0.0000000729 0.0002459835698877307 6.791821030730467e-07 0.000246 1
608 PHACTR3_1 0.0000000457 0.0002459835698877307 0.00011686809560116665 0.000246 1
609 RTN1_1 0.0000006098 0.0002459835698877307 4.222711647559608e-07 0.000246 1
610 STMN2_1 0.0000012964 0.0002459835698877307 4.094884978838306e-05 0.000246 1
611 AP2S1_2 0.0000000002 0.0002471622654017496 1.0198622949899072e-05 0.000247 1
612 ZFYVE21_1 0.0000194549 0.00025234279143195943 5.133817635619759e-06 0.000252 1
613 UNC13A_1 0.0000014726 0.00028614552404424633 2.0145584910723037e-05 0.000286 1
614 HRH3_2 0.0000000245 0.00028947620258979817 6.225133521987448e-05 0.000289 1
615 SLC46A3_1 0.0000004395 0.00029139375190295606 3.1273990762894294e-06 0.000291 1
616 FANCF_1 0.0000011239 0.00029389877591584477 0.00014597857403495873 0.000294 1
617 NUP188_1 0.0000001812 0.0003007412862887539 4.955407744532583e-06 0.000301 1
618 RASL11B_4 0.0000000000 0.00031499165163320023 4.227422993905127e-06 0.000315 1
619 RPL35A_1 0.0000009189 0.0003258993441790789 7.814046683768043e-08 0.000326 1
620 MRPS34_2 0.0000000002 0.0003472766416957016 2.882909993280601e-07 0.000347 1
621 GIMAP2_3 0.0000000036 0.0003570706360030332 0.00045579260491531034 0.000357 1
622 CEP290_2 0.0000000344 0.00037108570224806444 2.0125145944135785e-07 0.000371 1
623 GLTPD1_2 0.0000000118 0.0003718951957804949 0.0006320584367733676 0.000372 1
624 GPHN_2 0.0000000007 0.0003773923191660758 5.22047699300538e-06 0.000377 1
625 CASP1_1 0.0000000068 0.00037839447623271325 6.1495186991073225e-09 0.000378 1
626 ZNF696_1 0.0000000962 0.00037839447623271325 2.4615255354876653e-06 0.000378 1
627 PUM2_1 0.0000026305 0.0003816779304374477 3.3222971313684545e-07 0.000382 1
628 MEIS1_3 0.0000004107 0.0003904462676161654 0.0007682186961292422 0.00039 1
629 IFI30_1 0.0000012163 0.00040506375286474184 9.574423734042937e-07 0.000405 1
630 IL11RA_1 0.0000001170 0.0004052971561229435 2.655673357753088e-06 0.000405 1
631 NUCB2_1 0.0000013611 0.0004052971561229435 5.5618984098014e-07 0.000405 1
632 PTP4A3_1 0.0000000680 0.0004052971561229435 5.887768664427049e-08 0.000405 1
633 ADRBK2_2 0.0000000000 0.0004093391300622974 1.5783568509062198e-06 0.000409 1
634 PKIG_3 0.0000000000 0.00041171580743841403 3.057193996659834e-08 0.000412 1
635 SET_2 0.0000000001 0.0004229662691805196 1.4462314562288453e-05 0.000423 1
636 FLII_4 0.0000000000 0.000424309729157916 2.721972050662147e-05 0.000424 1
637 ARF6_1 0.0000010688 0.00044644151159829265 4.777162467883633e-05 0.000446 1
638 HMGCR_1 0.0000039108 0.0004491267996311823 9.51430189572535e-06 0.000449 1
639 ST8SIA3_1 0.0000019568 0.0004491267996311823 4.900547697748023e-06 0.000449 1
640 UNC80_1 0.0000008226 0.0004491267996311823 1.005782022353512e-07 0.000449 1
641 CCT8_3 0.0000000347 0.00045011610035894004 2.032003598923382e-06 0.00045 1
642 TRIM28_1 0.0000148486 0.00045014028192995044 3.949110489775901e-06 0.00045 1
643 CDC25A_2 0.0000000098 0.0004534776514099725 1.5512971032931264e-06 0.000453 1
644 GLTP_2 0.0000000028 0.00046494643788992516 5.8185552156116945e-06 0.000465 1
645 CCDC77_1 0.0000004612 0.0004974933526793384 4.507699749268401e-07 0.000497 1
646 MCF2L_1 0.0000000690 0.0005027123562350216 7.202072224189724e-07 0.000503 1
647 SLC6A2_2 0.0000001185 0.000506059688566897 2.28692972901338e-08 0.000506 1
648 SYP_2 0.0000001356 0.000506059688566897 6.3185873271940225e-06 0.000506 1
649 CNOT6_1 0.0000013898 0.0005152101842532016 1.3714419618221151e-06 0.000515 1
650 VARS_1 0.0000000157 0.0005152101842532016 6.389630116189804e-11 0.000515 1
651 IFITM3_4 0.0000000000 0.0005174358092289639 1.9647037009697173e-05 0.000517 1
652 PEX5_1 0.0000022882 0.0005345944155461007 2.4708316986247094e-07 0.000535 1
653 SLC31A2_2 0.0000000257 0.0005474521677410701 1.2568064895404654e-06 0.000547 1
654 GRIK3_1 0.0000076075 0.0005728902408745853 5.005291812592071e-05 0.000573 1
655 VN1R1_1 0.0000028939 0.0006456808009902826 1.5945573929220053e-06 0.000646 1
656 TFB2M_1 0.0000001636 0.0006554884190714251 8.29128842666871e-07 0.000655 1
657 MAD2L1_1 0.0000002657 0.000678865345560909 0.00022984708856661868 0.000679 1
658 MCM7_1 0.0000003921 0.000678865345560909 2.3157502863099238e-08 0.000679 1
659 MLF1IP_1 0.0000001155 0.000678865345560909 1.6356325391481808e-06 0.000679 1
660 RFC3_1 0.0000001961 0.000678865345560909 1.1405622586556333e-05 0.000679 1
661 RPL13A_5 0.0000000036 0.0006975780500730752 2.039076211055246e-07 0.000698 1
662 LINGO2_5 0.0000000000 0.0007331284191550658 3.7702692631153038e-06 0.000733 1
663 DNAJC22_1 0.0000621331 0.0007382242549827655 0.000384678461175607 0.000738 1
664 LAPTM4B_5 0.0000000199 0.0008008831004583888 1.799793994988323e-08 0.000801 1
665 MRPL21_1 0.0000002469 0.000813643911578377 2.155726402205982e-11 0.000814 1
666 KBTBD6_5 0.0000000012 0.0008752905126922217 5.094541684026646e-07 0.000875 1
667 ENDOD1_1 0.0000010618 0.0009656194251740187 1.0198902416156784e-06 0.000966 1
668 DYNLT3_1 0.0000002295 0.0009791477447292118 3.4005766399654322e-06 0.000979 1
669 FBXO33_3 0.0000001392 0.00103117959256628 0.0005017044994385344 0.001031 1
670 MAGT1_3 0.0000000006 0.0011183473761450665 3.282773317248208e-06 0.001118 1
671 RAP2C_1 0.0000000589 0.0012216917856767418 2.1738080076458742e-06 0.001222 1
672 UNC13A_4 0.0000000000 0.0012433758358174857 1.4243994675867104e-05 0.001243 1
673 MFAP5_1 0.0000031279 0.0012466841325621532 3.1380128368492257e-06 0.001247 1
674 CUX2_2 0.0000000011 0.001257136009743649 7.431311834991675e-07 0.001257 1
675 MED25_5 0.0000000204 0.001313200027316744 1.4936727700519996e-05 0.001313 1
676 MYT1L_2 0.0000000108 0.0013890971495074075 1.0025847658579697e-06 0.001389 1
677 TMEM18_2 0.0000076695 0.0013942235684900853 1.707287632066412e-07 0.001394 1
678 CCT7_1 0.0000001734 0.001443320215490813 1.1968773859770425e-09 0.001443 1
679 MAK16_1 0.0000004814 0.001443320215490813 2.3072064933343512e-09 0.001443 1
680 MRPS21_1 0.0000000540 0.001443320215490813 6.719016265932361e-09 0.001443 1
681 POLR1B_1 0.0000003351 0.001443320215490813 1.7793565095841775e-08 0.001443 1
682 GTPBP1_2 0.0000000021 0.001459680524809358 0.00015614452037923833 0.00146 1
683 EBF3_1 0.0000010072 0.0014691176249919573 8.044891819455788e-07 0.001469 1
684 MTUS1_2 0.0000935307 0.0015509534579936969 1.105438193098732e-06 0.001551 1
685 NUP133_2 0.0000000014 0.0015899100236963135 1.3303993388626396e-05 0.00159 1
686 CTNND1_2 0.0000000000 0.001732526914901912 3.072309330628804e-05 0.001733 1
687 NDUFB9_1 0.0000000238 0.0017523496068642189 5.3915212453729005e-09 0.001752 1
688 SLC9A7_1 0.0000003133 0.0017523496068642189 1.2535099503914342e-05 0.001752 1
689 EIF4ENIF1_1 0.0000108333 0.0017678348648425643 3.7197697739906752e-06 0.001768 1
690 DOCK1_1 0.0000181948 0.001772102755233229 1.4070332453720584e-06 0.001772 1
691 RPL32_1 0.0000022322 0.001777378099890663 6.225050246986396e-05 0.001777 1
692 PRICKLE2_1 0.0000006847 0.0018473350729729212 2.0385221521213067e-05 0.001847 1
693 RUFY3_1 0.0000070188 0.0018473350729729212 1.8701260489318547e-05 0.001847 1
694 WNT5A_1 0.0000028497 0.0018473350729729212 2.708727992064078e-06 0.001847 1
695 MPHOSPH10_2 0.0000000007 0.0018678908445817427 1.5239795553355398e-06 0.001868 1
696 ARID3A_1 0.0000002399 0.0019027179320774803 5.715891598653691e-07 0.001903 1
697 HBQ1_1 0.0000006406 0.0019027179320774803 6.157621558231056e-07 0.001903 1
698 CAPG_5 0.0000000000 0.001947090513575717 7.749723393890698e-06 0.001947 1
699 YARS2_2 0.0005979379 0.0019907006334396776 5.679834094373692e-07 0.001991 1
700 KIAA0247_5 0.0000000008 0.001994915026343904 7.399520670189372e-07 0.001995 1
701 ATP6V1A_1 0.0000002721 0.0020456136275657888 5.629476223876873e-08 0.002046 1
702 NFXL1_3 0.0000000000 0.0020758764777589786 5.099976094773998e-07 0.002076 1
703 RIOK3_3 0.0000000003 0.0021500812901470065 0.00030023156807518783 0.00215 1
704 AKR7A2_4 0.0000000023 0.0021553658383185563 2.358890665005359e-05 0.002155 1
705 THOC1_3 0.0000009047 0.002194182322111777 0.00021664763805975321 0.002194 1
706 COPG_1 0.0000003427 0.0021961385175434875 8.880302868410324e-08 0.002196 1
707 RPL13_1 0.0000004776 0.002391299161389133 4.361906742412738e-06 0.002391 1
708 ARRB2_2 0.0000000003 0.0024223436617129856 8.170313945294133e-05 0.002422 1
709 CCDC41_2 0.0000005081 0.0024621645703630526 1.7620046187445725e-05 0.002462 1
710 WDR75_5 0.0000000001 0.0024742390938208743 2.813266963497791e-07 0.002474 1
711 LRBA_4 0.0000000000 0.002519709257235862 0.0002137598179932144 0.00252 1
712 BAI3_2 0.0000000007 0.002579529817958645 3.1862597515464765e-08 0.00258 1
713 FKBP4_1 0.0000009273 0.0026665845796536394 3.954836683246733e-07 0.002667 1
714 H3F3B_1 0.0000006090 0.0026665845796536394 1.0621184124507563e-07 0.002667 1
715 LRRC45_1 0.0000035848 0.002695070404947365 0.005476743217592932 0.002695 1
716 VPRBP_1 0.0000098159 0.0028451265399304145 0.00033046637508825843 0.002845 1
717 KIF1A_1 0.0000002287 0.002859168680149655 7.313472575923523e-07 0.002859 1
718 RPL3_1 0.0001386435 0.0028919508671728217 4.887776236374372e-07 0.002892 1
719 ABI3BP_1 0.0000085821 0.003065043011644369 1.0951385360313097e-07 0.003065 1
720 FBRSL1_1 0.0000038191 0.0030838618137353662 2.4058708516257493e-06 0.003084 1
721 RAB3C_1 0.0000001743 0.0030838618137353662 2.7538671921394696e-07 0.003084 1
722 C16orf59_1 0.0000000275 0.0031574556401693433 1.5986180058945153e-05 0.003157 1
723 NUP35_1 0.0000004963 0.0031574556401693433 1.514239152011962e-06 0.003157 1
724 LPIN2_1 0.0000098827 0.0034466689399791843 2.452952119077932e-06 0.003447 1
725 ZNF507_2 0.0000000111 0.003820596558681088 0.00011453249175240676 0.003821 1
726 ADAM10_1 0.0000233014 0.0038798255226726924 6.64776252928381e-06 0.00388 1
727 FBXL18_1 0.0000066755 0.0038798255226726924 7.005071001453964e-05 0.00388 1
728 TMOD3_1 0.0000078430 0.0038798255226726924 1.2077163895524178e-08 0.00388 1
729 HLCS_3 0.0000000014 0.003897587461379324 6.778958570865246e-05 0.003898 1
730 NYNRIN_1 0.0000000051 0.0040253432504568695 5.327811563265487e-06 0.004025 1
731 PDXK_1 0.0000012454 0.0041233566091711665 6.342148817937973e-09 0.004123 1
732 RPS11_3 0.0000000443 0.0043239457542860625 1.7167121527934926e-08 0.004324 1
733 LCE2B_1 0.0000000888 0.004326577770871151 8.013095879242094e-06 0.004327 1
734 MAP2K7_3 0.0000000490 0.004508166201072404 3.487700085903893e-07 0.004508 1
735 PATZ1_1 0.0000004164 0.004557941079021841 3.004553790169959e-08 0.004558 1
736 SMCR7L_1 0.0000000162 0.004557941079021841 1.0835431093170762e-07 0.004558 1
737 CNTNAP2_1 0.0000001099 0.004613449756294485 2.310283526460759e-05 0.004613 1
738 SLC29A3_1 0.0000003134 0.004613449756294485 4.496266117362092e-06 0.004613 1
739 ZBTB34_1 0.0000040446 0.004618680063226724 8.498577839821885e-07 0.004619 1
740 PRKAA1_2 0.0000001321 0.004627796941857709 5.55517925893019e-06 0.004628 1
741 IRF1_2 0.0000000003 0.004777571752988573 6.77745840075317e-08 0.004778 1
742 GDAP1L1_5 0.0000000002 0.004808546917289599 1.5091907669172042e-06 0.004809 1
743 NUP205_2 0.0000009871 0.004863314597556403 0.0012109741287245038 0.004863 1
744 NUS1_1 0.0000000240 0.005366950975922179 3.380290864221785e-05 0.005367 1
745 GOLT1B_3 0.0000022695 0.005599828148522198 3.3515801939710514e-08 0.0056 1
746 SEC24A_2 0.0000000249 0.005701481885121388 7.068590877915707e-08 0.005701 1
747 AVEN_1 0.0000004065 0.005953586357194907 1.3650737340980481e-05 0.005954 1
748 BRD3_1 0.0000002324 0.0060047412034100744 7.118719879444557e-05 0.006005 1
749 CBX5_1 0.0000008271 0.0060047412034100744 2.073650192477865e-07 0.006005 1
750 ZNF689_1 0.0000000501 0.006037283839286274 8.7110715845335e-07 0.006037 1
751 RHOG_5 0.0000003561 0.006148753448353471 4.9151555577284784e-05 0.006149 1
752 SPRY1_4 0.0000003345 0.006174801125444205 0.0033247321236384107 0.006175 1
753 NR1H2_2 0.0000000004 0.006201080908802092 7.565957176888148e-05 0.006201 1
754 RTKN2_1 0.0000066891 0.006287821872432228 2.618709167085205e-06 0.006288 1
755 CHRNA5_1 0.0000056104 0.006387086743044337 1.5554788280693852e-06 0.006387 1
756 PEBP1_1 0.0000011028 0.006389356754277303 3.377019522860942e-08 0.006389 1
757 CNOT6_1 0.0000000995 0.0064218708869592965 1.2731573046468182e-07 0.006422 1
758 FEM1B_1 0.0000014595 0.006512658184422679 1.2419959836180664e-05 0.006513 1
759 PDCD2L_1 0.0000198400 0.006732981542919481 7.754024385726151e-07 0.006733 1
760 BCCIP_2 0.0000000036 0.006993057619665846 1.8570072163956842e-07 0.006993 1
761 C17orf80_2 0.0000003489 0.007022396430063894 9.534705566156907e-06 0.007022 1
762 TMEM229A_1 0.0000014642 0.007033451966587178 4.488027198291259e-06 0.007033 1
763 AKAP1_1 0.0000048789 0.007054606953047138 2.2520683380861938e-08 0.007055 1
764 EPC2_1 0.0000187282 0.007054606953047138 3.1361338152693263e-06 0.007055 1
765 FKBP14_1 0.0000001541 0.007054606953047138 5.2000405163879345e-08 0.007055 1
766 HMGB1_1 0.0000243369 0.007054606953047138 3.5582530664664353e-06 0.007055 1
767 TMEM167B_1 0.0000089984 0.007054606953047138 4.903843719615824e-08 0.007055 1
768 FURIN_1 0.0000013583 0.007154235078360664 0.0024498354764936592 0.007154 1
769 FUZ_2 0.0000000010 0.007484149048900862 8.06345585283052e-07 0.007484 1
770 RAX_1 0.0000005607 0.007849325275374927 1.5165025207033165e-06 0.007849 1
771 HSPA5_1 0.0000233798 0.00804650712219702 3.3345569936160264e-07 0.008047 1
772 SEZ6_1 0.0000001552 0.00809133905523077 2.1206134094154278e-05 0.008091 1
773 CDC7_2 0.0000090196 0.00818484412008511 5.21476362116686e-05 0.008185 1
774 TIMELESS_2 0.0000000005 0.008348387787825583 1.1506564136074267e-05 0.008348 1
775 FAIM2_1 0.0000004595 0.008633031029057705 7.868329291267168e-08 0.008633 1
776 PKIA_1 0.0000117746 0.008813705248904322 1.6109769990275906e-08 0.008814 1
777 MRFAP1L1_1 0.0000000173 0.009220967328515883 2.2849973360661935e-07 0.009221 1
778 SLC4A8_1 0.0000432316 0.010311927011747773 2.2746479512952496e-06 0.010312 1
779 SAMM50_1 0.0000040988 0.010582443118030336 5.607191574381122e-07 0.010582 1
780 FAM129A_1 0.0000110292 0.010610163045225487 0.00021553454881793465 0.01061 1
781 AFMID_5 0.0000000000 0.011037504835486236 6.903237042102531e-06 0.011038 1
782 STARD7_1 0.0000008193 0.011230798403991177 1.4750425191704724e-06 0.011231 1
783 GPN2_2 0.0000000003 0.011286646172223367 0.0002020338349948365 0.011287 1
784 PCDH9_1 0.0000115514 0.01159836162693171 2.5431326048421465e-05 0.011598 1
785 DDOST_2 0.0000006862 0.011732466260948907 7.712332840561586e-07 0.011732 1
786 TMEM109_3 0.0000000174 0.01179210198130457 1.34476580166563e-05 0.011792 1
787 OLA1_2 0.0000001004 0.01186517030330062 3.4419370304963574e-06 0.011865 1
788 RGS3_4 0.0000000707 0.012273010269850448 8.926332727725615e-07 0.012273 1
789 HMGCL_1 0.0000057648 0.013135841653707197 6.151145606016247e-07 0.013136 1
790 SIPA1L1_1 0.0000004161 0.013135841653707197 1.518269230551228e-06 0.013136 1
791 TMEM50A_1 0.0000006936 0.013135841653707197 2.3186309995661696e-05 0.013136 1
792 AP2S1_2 0.0005534120 0.013321879037458757 2.1009217572593065e-05 0.013322 1
793 NARF_1 0.0000001706 0.01356093601279795 7.558805657306656e-07 0.013561 1
794 S100A2_2 0.0000000045 0.013795138693676535 0.0009724391668072714 0.013795 1
795 STX8_2 0.0010456927 0.013842934358702711 6.244242975666368e-07 0.013843 1
796 SLC10A4_3 0.0000000008 0.0147620266284032 0.00012936185099713163 0.014762 1
797 KCNAB1_1 0.0000177047 0.014856183619266723 1.5321385429315337e-05 0.014856 1
798 NUFIP1_1 0.0000040928 0.015328857071669418 1.4820509456787599e-05 0.015329 1
799 PUS7_1 0.0002258870 0.015382714940475899 0.0003699975490667046 0.015383 1
800 TMEM33_1 0.0000021939 0.015382714940475899 7.8917032520098e-05 0.015383 1
801 SUPT4H1_1 0.0000076733 0.015545833082593517 3.111378512146274e-05 0.015546 1
802 B4GALT1_2 0.0000000036 0.015866838196212218 4.984509522594122e-08 0.015867 1
803 TRMT1_1 0.0000002555 0.016113877031426083 3.5979546226837025e-05 0.016114 1
804 ITCH_1 0.0000006285 0.016311084928625978 3.67059506817032e-06 0.016311 1
805 SLC41A2_1 0.0000027434 0.016829575684385905 0.0002722352435422239 0.01683 1
806 UBXN1_1 0.0000006760 0.01695446499444467 2.7446548902174226e-06 0.016954 1
807 AARS2_1 0.0000130548 0.017241329872294712 5.7037625716450966e-05 0.017241 1
808 ASB13_1 0.0000238679 0.017330336075027382 4.6209737153601604e-07 0.01733 1
809 CSDA_1 0.0000009251 0.017443397981769932 0.0011464157798244399 0.017443 1
810 DBH_1 0.0000079113 0.017443397981769932 1.4347684455753113e-06 0.017443 1
811 DOK4_1 0.0000231034 0.017443397981769932 6.618729332114159e-06 0.017443 1
812 FAM57B_1 0.0000016227 0.017443397981769932 5.886088725233178e-06 0.017443 1
813 GRIA4_1 0.0000003095 0.017443397981769932 2.302309309599117e-05 0.017443 1
814 IGFBPL1_1 0.0000008576 0.017443397981769932 4.783176130914827e-07 0.017443 1
815 NFKBIZ_1 0.0000162804 0.017443397981769932 3.3994720134388014e-06 0.017443 1
816 PIEZO1_1 0.0000001897 0.017443397981769932 1.8246285080698113e-06 0.017443 1
817 SCN3B_1 0.0000011607 0.017443397981769932 1.5135394267848417e-06 0.017443 1
818 SNAP91_1 0.0000071468 0.017443397981769932 2.638244061314773e-07 0.017443 1
819 TMEM151B_1 0.0000049076 0.017443397981769932 2.6430931809230297e-05 0.017443 1
820 TRAM1_1 0.0000027969 0.017443397981769932 1.6694679799715998e-06 0.017443 1
821 DLGAP2_1 0.0000034653 0.017999463759106323 2.855153777346279e-05 0.017999 1
822 GFRA2_2 0.0000000003 0.018137077932381954 0.000951735145248877 0.018137 1
823 C12orf44_5 0.0000000000 0.018866742690223485 8.109600906363036e-06 0.018867 1
824 CPD_2 0.0000000009 0.018958927953712085 1.967423231238389e-05 0.018959 1
825 UNG_3 0.0000000006 0.019815116785847253 0.00017623188278973096 0.019815 1
826 AGAP2_1 0.0000012045 0.020393810250137884 8.442387558423992e-06 0.020394 1
827 DPY19L4_1 0.0000013827 0.020459674602965643 1.4759797172005466e-06 0.02046 1
828 UST_1 0.0000248242 0.020499190298611462 6.68339412744453e-08 0.020499 1
829 MAP2K7_1 0.0000028217 0.020602652898910816 1.2164780555581337e-05 0.020603 1
830 DLG1_1 0.0000000204 0.02077959376727299 9.890664601929713e-06 0.02078 1
831 MAPK8IP2_1 0.0000001600 0.021209400010728994 1.2744882761058085e-05 0.021209 1
832 TARDBP_3 0.0000000007 0.021265954498108135 6.908159765653427e-06 0.021266 1
833 CYLD_1 0.0000000217 0.0214858173069357 9.879543686944467e-07 0.021486 1
834 ATL2_1 0.0000013494 0.021736958168253658 8.154925885406086e-06 0.021737 1
835 SCAMP5_1 0.0000005258 0.02223324975104475 6.003509085007509e-09 0.022233 1
836 ARL6IP5_1 0.0000000067 0.02225726819150785 1.956141813979619e-06 0.022257 1
837 TUBD1_1 0.0000003011 0.02263296125661172 7.713138636684567e-05 0.022633 1
838 OLFM3_1 0.0000089344 0.022851610694445912 1.8829513375080384e-05 0.022852 1
839 ODC1_2 0.0000008568 0.022971832631374724 2.7504995269216484e-06 0.022972 1
840 EXOSC8_4 0.0000000000 0.022989772746273066 0.0001824993302681246 0.02299 1
841 GEMIN5_4 0.0000000017 0.023273422660848357 7.022368029898661e-07 0.023273 1
842 BCLAF1_1 0.0000031831 0.023433853775319136 1.6892927173134977e-06 0.023434 1
843 ADAMTSL2_3 0.0000000000 0.02345493378746214 2.0324998641713588e-05 0.023455 1
844 GSDMD_1 0.0003698567 0.02361947064385562 1.260266686331163e-05 0.023619 1
845 FILIP1L_1 0.0000442945 0.02380535004803143 4.139244014504424e-06 0.023805 1
846 MPP5_1 0.0000013996 0.024393557193549072 5.899482289097565e-07 0.024394 1
847 ZNF781_2 0.0000000214 0.024442804805679837 0.0002430481092405698 0.024443 1
848 GREB1_1 0.0000021946 0.025082579510674555 1.026168781803766e-06 0.025083 1
849 MICAL2_1 0.0000051045 0.025082579510674555 5.460450875355455e-06 0.025083 1
850 MLKL_1 0.0000245887 0.02520256529276301 1.5181921351787456e-07 0.025203 1
851 HIATL1_1 0.0000001697 0.025698116096895575 0.0006037318193258467 0.025698 1
852 POFUT2_3 0.0000002159 0.025815308401600554 3.356964828070045e-08 0.025815 1
853 FSD1L_3 0.0000000005 0.026091908369487455 0.00039856129823143474 0.026092 1
854 SLC22A4_1 0.0000007929 0.026358068088106524 5.592144002080514e-06 0.026358 1
855 ECE1_1 0.0000040064 0.027281965933944777 3.1606809203074195e-06 0.027282 1
856 FAM120C_1 0.0000001526 0.027478094280566072 9.440653359830993e-06 0.027478 1
857 WDR18_1 0.0000002870 0.02811272649847224 2.0929795909688486e-06 0.028113 1
858 SPAST_2 0.0000001330 0.028348027782966405 3.9367533477728655e-06 0.028348 1
859 RIN2_1 0.0000003608 0.028653860870043152 1.4769971196556159e-05 0.028654 1
860 RUNX2_2 0.0000000005 0.028974052520507214 2.14065240634782e-06 0.028974 1
861 NOP14_2 0.0000005983 0.02901206601493043 9.523685001792411e-07 0.029012 1
862 MAN2B2_1 0.0000027972 0.029245906890336886 1.4933063823416558e-06 0.029246 1
863 PAIP1_1 0.0000007230 0.029320244216402155 2.7441426734443414e-07 0.02932 1
864 DHX32_2 0.0000533846 0.029344624633688917 6.043863871216864e-07 0.029345 1
865 PLK2_2 0.0002388183 0.029905384844343543 2.063197005965159e-06 0.029905 1
866 PRCC_1 0.0000001861 0.029926219059845965 1.1405008131610388e-06 0.029926 1
867 XAF1_1 0.0000358261 0.030280074734233196 7.286165792821834e-08 0.03028 1
868 METAP2_1 0.0000087458 0.030556265901493518 3.240583308159839e-07 0.030556 1
869 CLK2_1 0.0000011413 0.030888289103249412 7.675595673276064e-06 0.030888 1
870 DPP6_1 0.0000000203 0.03100397440582499 5.0469470139700276e-05 0.031004 1
871 ACSL4_3 0.0000020398 0.03149060869705135 1.5068270568910291e-05 0.031491 1
872 ANKIB1_1 0.0000005533 0.032332967518234994 5.693423471624403e-07 0.032333 1
873 MRPL44_1 0.0000004285 0.03320176795710607 7.58534516483232e-07 0.033202 1
874 ECSIT_1 0.0000000613 0.033538144332397844 9.327207467647707e-06 0.033538 1
875 UTRN_1 0.0000011107 0.033538144332397844 2.5789968645189164e-06 0.033538 1
876 KLHL3_1 0.0000383917 0.0344114911006157 3.244555435191599e-05 0.034411 1
877 PPP3CC_1 0.0004859138 0.03515778354911297 6.188875946486586e-05 0.035158 1
878 ZNF146_2 0.0000000002 0.03744996129971014 0.00011861207253864054 0.03745 1
879 ZNF561_1 0.0000000634 0.03880023351870834 2.016596236878262e-06 0.0388 1
880 GABRB3_2 0.0000004163 0.03908988372883462 1.4145265356070185e-06 0.03909 1
881 FUCA2_2 0.0000010455 0.040900774628950205 4.509971577380666e-08 0.040901 1
882 ZNF704_1 0.0000003968 0.04141199786610875 3.2915671737970186e-07 0.041412 1
883 RSRC2_1 0.0000006681 0.04263760212726399 8.124905418115654e-06 0.042638 1
884 ZNF786_4 0.0000003689 0.04302185346161887 0.00017227082461867952 0.043022 1
885 FAM208A_4 0.0000001168 0.04317698799820883 6.901563255423604e-06 0.043177 1
886 KLC1_2 0.0000000029 0.04326421162343569 9.50085593569108e-05 0.043264 1
887 C4orf46_1 0.0000014299 0.04398087969459366 0.0001711178965703045 0.043981 1
888 PFDN2_1 0.0000002586 0.044291333594155616 1.8451067079767974e-09 0.044291 1
889 TMEM88_1 0.0000001338 0.04436920294909983 3.529178026304605e-07 0.044369 1
890 CAMKMT_1 0.0000058447 0.045390286722626634 3.532704674941749e-05 0.04539 1
891 RAB3A_5 0.0000000000 0.04677739444487693 1.0728714113996382e-05 0.046777 1
892 PPP1R3C_1 0.0000160727 0.046988563883468094 6.183139691881509e-07 0.046989 1
893 RNPS1_1 0.0000017303 0.04934110523099186 2.7030460144558537e-06 0.049341 1
894 SESN1_1 0.0000827949 0.049980571686550485 0.00013996827329482083 0.049981 1
[표 8]에는 두경부암(head&neck) 약물에 연관된 FRH 들과, 이와 연관된 두경부암 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 9] 에는 [표 8]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(Pvlaue)값을 의미하는 것으로, [표 8]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 8]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 두경부암 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 31에는 표 8에 기재된 바이오마커들 중 주요 바이오마커들의 두경부암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 32에는 주요 바이오마커들에 의해 발현된 유전자들과 두경부암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
두경부암(head&neck) 약물에 대한 반응성 바이오 마커
No. FRH Drug DrugType Var(마커)
1 RAI14_2 60_BI-2536 / 87_GW843682X / 150_Bicalutamide / 155_AP-24534 / 269_NSC-207895 / 295_NVP-BHG712 / 341_EX-527 / 1016_Temsirolimus / 1032_Afatinib / 1036_PLX4720 / 1057_NVP-BEZ235 / 1061_SB590885 / 1175_AG-014699 / 1219_PFI-1 / 1241_CHIR-99021 / 1242_(5Z)-7-Oxozeaenol / 1371_PLX4720 (rescreen) / 1372_Trametinib / 1373_Dabrafenib / 1377_Afatinib (rescreen) mitosis / mitosis / other / abl / p53 / rtk / other / tor / egfr / erk_mapk / pi3k / erk_mapk / g_integrity / chromatin / wnt / other / erk_mapk / erk_mapk / erk_mapk / egfr 14_21082261_T_G / 7_140753336_A_T
2 ELK3_1 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 / 1526_Refametinib_3 / 1371_PLX-4720_3 / 1372_Trametinib_1 erk_mapk / other / erk_mapk / erk_mapk / erk_mapk 14_21082261_T_G
3 RAI14_2 1373_Dabrafenib_1 / 1371_PLX-4720_3 / 1242_(5Z)-7-Oxozeaenol_3 erk_mapk / erk_mapk / other 14_21082261_T_G / 5_94871301_T_G
4 NOTCH2_1 1371_PLX-4720_3 / 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 erk_mapk / erk_mapk / other 20_63940084_T_G
5 CATSPER1_1 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 erk_mapk / other 7_140753336_A_T
6 TNIP1_2 1373_Dabrafenib_1 / 1371_PLX-4720_3 erk_mapk / erk_mapk 5_154823483_T_G / 15_32616231_T_G
7 PTX3_2 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 erk_mapk / other 7_140753336_A_T / 14_21082261_T_G
8 ZHX3_1 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 erk_mapk / other 7_72926354_C_T
9 SH2D3A_1 1010_Gefitinib_1 / 1377_Afatinib_1 egfr / egfr 6_129475475_C_T
10 SLC39A13_5 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 erk_mapk / other 14_21082261_T_G / 7_140753336_A_T / 11_85724752_T_C / 3_48790461_T_G / 17_35259011_T_G
11 GJB6_1 1032_Afatinib_1 / 1114_Cetuximab_1 egfr / egfr 1_44978366_G_A
12 PLAU_2 1494_SN-38_3 / 1259_Talazoparib_3 DNArep / g_integrity 16_2519752_T_C / 9_114307582_T_G
13 ATG7_1 1373_Dabrafenib_1 erk_mapk 7_140753336_A_T
14 CACNG4_3 1373_Dabrafenib_1 erk_mapk 7_140753336_A_T / 16_11174168_A_G / 6_5771301_A_C
15 GJB2_1 1032_Afatinib_1 egfr 1_44978366_G_A
16 DOCK4_2 1373_Dabrafenib_1 erk_mapk 9_76227464_A_G / 7_140753336_A_T
17 AP1M2_3 1377_Afatinib_1 egfr 1_2521130_T_C / 12_50718803_T_C / 1_2491175_G_A
18 RNF216_1 1021_Axitinib_2 rtk 10_45443298_C_T
19 IRX2_3 1373_Dabrafenib_1 erk_mapk 1_2562891_G_A / 12_14460981_T_A / 7_140753336_A_T
20 CXADR_4 1242_(5Z)-7-Oxozeaenol_3 other 14_21082261_T_G / 3_47333236_T_C / 18_8387094_T_G / 17_63831142_T_G
21 NEBL_1 1242_(5Z)-7-Oxozeaenol_3 other 7_72926354_C_T
22 FXYD3_1 1032_Afatinib_1 egfr 22_50625559_G_C
23 SERPINB5_1 1032_Afatinib_1 egfr 22_50625559_G_C
24 GJB3_1 1010_Gefitinib_1 egfr 6_129475475_C_T
25 GJB5_1 1010_Gefitinib_1 egfr 6_129475475_C_T
26 WNT10A_1 1010_Gefitinib_1 egfr 6_129475475_C_T
27 ACLY_1 255_CP724714_2 egfr 15_26976868_T_A
28 KRT6A_1 1114_Cetuximab_1 egfr 22_50576781_G_C
29 PRADC1_1 1037_BX796_2 other 2_53899904_C_T
30 TIMP1_1 1373_Dabrafenib_1 erk_mapk 19_9985806_C_T
31 GYLTL1B_2 1032_Afatinib_1 egfr 7_5938011_C_CCA / 7_5945090_C_T
32 PTCHD4_4 1373_Dabrafenib_1 erk_mapk 11_4102115_C_G / 11_4132537_A_G / 11_4112087_C_A / 11_4138236_G_A
두경부암(head&neck) 약물에 대한 바이오 마커의 반응성 검증 결과
No. FRH Var_Exp(pval) Var_Drug(pval) Exp_Drug(pval) Ave_VarDrug(pval) Rank
1 RAI14_2 1.50E-07 0.002427316 / 0.007905787 / 0.009050202 / 0.008885028 / 0.006973327 / 0.008993803 / 0.006448846 / 0.003370265 / 0.005536324 / 7.23E-05 / 0.008957232 / 0.006831953 / 0.007786364 / 0.009533459 / 0.002310426 / 0.006104376 / 2.92E-05 / 0.003064818 / 1.61E-05 / 0.009911234 0.07094644 / 0.187614118 / 0.000121399 / 0.070569119 / 0.006038396 / 0.070019258 / 0.001656899 / 0.051790523 / 0.024868194 / 0.001587975 / 0.005704322 / 0.20488317 / 0.010104768 / 0.019630304 / 0.019900005 / 1.24E-05 / 2.38E-05 / 0.00050772 / 1.09E-06 / 0.018141082 0.00571 20
2 ELK3_1 0.0000051495 8.520565972551354e-05 / 0.015525162300909256 / 0.022555240944218617 / 9.519623606517973e-05 / 0.007329786178994242 1.490382050697451e-07 / 5.969489582574335e-06 / 6.8362891216619816e-06 / 9.005519185972905e-06 / 6.49148403527597e-05 0.009118 5
3 RAI14_2 0.0000000017 0.0008802720058814783 / 4.733202001463438e-05 / 0.011225192753415226 1.0853407136502757e-06 / 2.4863984008159652e-05 / 1.2422979331681213e-05 0.004051 3
4 NOTCH2_1 0.0003642485 0.0022063266509928054 / 0.0011467762666252258 / 0.03692401606377258 8.758068948702604e-05 / 3.0310746014375745e-05 / 1.8526402456030966e-05 0.013426 3
5 CATSPER1_1 0.0000542935 4.909220079323596e-06 / 0.00011457004964965411 0.0004960672627266704 / 4.1877269236589585e-05 5.97E-05 2
6 TNIP1_2 0.0000000375 0.001606622034643822 / 2.7862939972941576e-05 0.0015404489011240819 / 5.038713072540372e-05 0.000817 2
7 PTX3_2 0.0000000676 1.211019112884484e-05 / 0.004691088270564708 5.3217448419493556e-05 / 4.863050561584803e-06 0.002352 2
8 ZHX3_1 0.0000014893 0.006509687182728191 / 0.008743794449442545 0.0040675934215217225 / 0.00019098934171098681 0.007627 2
9 SH2D3A_1 0.0000000320 0.00986450275259379 / 0.01796408266328998 7.462758949668892e-07 / 1.1020918776918554e-08 0.013914 2
10 SLC39A13_5 0.0000000002 0.00012981264623764855 / 0.030218992308456684 0.0004149038678616304 / 0.00016053338154515 0.015174 2
11 GJB6_1 0.0000254994 0.0011057846043825926 / 0.04337830840329379 4.1575916269860694e-08 / 1.3980763861975182e-05 0.022242 2
12 PLAU_2 0.0000006538 0.03531794281050409 / 0.02526666710345045 4.043892919121399e-05 / 3.9199708585004496e-05 0.030292 2
13 ATG7_1 0.0000274102 4.909220079323596e-06 0.009126969696896518 4.91E-06 1
14 CACNG4_3 0.0000000067 0.00039102555284760144 0.031972846680865336 0.000391 1
15 GJB2_1 0.0000006418 0.0011057846043825926 2.887574461802551e-08 0.001106 1
16 DOCK4_2 0.0000000000 0.0011991500921208242 0.0022356151864022953 0.001199 1
17 AP1M2_3 0.0000000001 0.0033347052264227745 1.674996902910247e-06 0.003335 1
18 RNF216_1 0.0007334440 0.003910529109685535 0.013334064866138773 0.003911 1
19 IRX2_3 0.0000000213 0.0039795105649417465 0.008040031167638424 0.00398 1
20 CXADR_4 0.0000000000 0.004008851856771511 0.00015472825463944093 0.004009 1
21 NEBL_1 0.0000067597 0.008743794449442545 1.0527193471616602e-05 0.008744 1
22 FXYD3_1 0.0008131704 0.009811440592786477 6.611291968968659e-11 0.009811 1
23 SERPINB5_1 0.0000043595 0.009811440592786477 6.545929986856144e-07 0.009811 1
24 GJB3_1 0.0000000848 0.00986450275259379 1.9745785897164974e-07 0.009865 1
25 GJB5_1 0.0000001095 0.00986450275259379 3.7414591927831155e-08 0.009865 1
26 WNT10A_1 0.0000000002 0.00986450275259379 1.0155161311414058e-06 0.009865 1
27 ACLY_1 0.0000197234 0.01038305959856784 0.0002073002808779262 0.010383 1
28 KRT6A_1 0.0000039996 0.011822174156922029 6.092827819585888e-07 0.011822 1
29 PRADC1_1 0.0000003553 0.01619549339490529 4.216127554465152e-06 0.016195 1
30 TIMP1_1 0.0000442505 0.019824604635656325 0.00012088359791880537 0.019825 1
31 GYLTL1B_2 0.0000000917 0.027132275398936593 1.8977666799314624e-07 0.027132 1
32 PTCHD4_4 0.0003324429 0.04021455535799824 0.0022163934450957286 0.040215 1
[표 10]에는 폐암(lung) 약물에 연관된 FRH 들과, 이와 연관된 폐암 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 11] 에는 [표 10]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(Pvlaue)값을 의미하는 것으로, [표 10]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 10]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 폐암 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 33에는 표 10에 기재된 바이오마커들 중 주요 바이오마커들의 폐암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 34에는 주요 바이오마커들에 의해 발현된 유전자들과 폐암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
폐암(lung) 약물에 대한 반응성 바이오 마커
No. FRH Drug DrugType Var(마커)
1 POLR3K_5 290_KIN001-260 / 287_KIN001-244 / 308_XL-880 / 261_TL-1-85 / 329_QL-XI-92 / 269_NSC-207895 / 332_XMD15-27 / 1268_XAV 939 / 1495_Olaparib / 260_NG-25 / 265_Tubastatin A / 1011_ABT-263 / 310_YM201636 / 249_XL-184 / 266_Zibotentan / 273_CUDC-101 / 1021_Axitinib / 277_ABT-869 / 1008_Methotrexate / 272_AR-42 / 271_VNLG/124 / 288_KIN001-055 / 312_AV-951 / 1375_Temozolomide / 346_THZ-2-102-1 / 262_VX-11e / 150_Bicalutamide / 206_Ruxolitinib / 328_SNX-2112 / 91_KIN001-135 / 1017_Olaparib / 300_CX-5461 / 152_CP466722 / 276_CAY10603 / 252_WZ3105 / 257_NPK76-II-72-1 / 1158_XMD11-85h / 226_GSK1070916 / 254_AC220 other / pi3k / rtk / other / rtk / p53 / other / wnt / g_integrity / other / chromatin / apop / other / rtk / other / chromatin / rtk / rtk / DNArep / chromatin / chromatin / other / rtk / DNArep / cell_cyc / erk_mapk / other / other / other / other / g_integrity / other / g_integrity / chromatin / other / mitosis / other / mitosis / rtk 2_217847583_C_T / 2_71424561_G_GT / 2_217847883_G_A / 2_217848003_A_G / 17_81206909_A_C
2 FAM114A1_1 326_GSK690693_3 / 1011_Navitoclax_2 / 252_WZ3105_3 / 1248_Daporinad_3 / 299_OSI-027_2 / 269_NSC-207895_3 / 226_GSK1070916_2 / 330_XMD13-2_3 / 302_PI-103_3 / 257_NPK76-II-72-1_3 / 331_QL-X-138_3 / 312_Tivozanib_2 pi3k / apop / other / metabol / tor / p53 / mitosis / other / pi3k / mitosis / other / rtk 2_217847583_C_T
3 AVPI1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 / 1007_Docetaxel_1 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1114_Cetuximab_1 / 1015_CI-1040_2 / 1378_Bleomycin(50uM)_1 / 1268_XAV939_3 / 1031_Elesclomol_2 erk_mapk / erk_mapk / other / erk_mapk / cytoskeleton / erk_mapk / erk_mapk / egfr / erk_mapk / DNArep / wnt / other 3_157413999_A_C
4 S100A11_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1014_Refametinib_2 / 1377_Afatinib_1 / 172_Embelin_2 / 1060_PD0325901_2 / 207_AS601245_3 / 1114_Cetuximab_1 / 1378_Bleomycin(50uM)_1 / 1032_Afatinib_1 erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / egfr / apop / erk_mapk / jnk_p38 / egfr / DNArep / egfr 11_124145287_C_T
5 TMEM92_2 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 51_Dasatinib_1 / 159_HG6-64-1_3 / 201_Epothilone B_2 / 1007_Docetaxel_1 / 207_AS601245_3 / 194_Luminespib_2 / 1054_Palbociclib_2 other / erk_mapk / erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk / cytoskeleton / cytoskeleton / jnk_p38 / other / cell_cyc 8_1565648_A_G / 9_61104415_C_T
6 ATP6V0B_1 1378_Bleomycin(50uM)_1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 51_Dasatinib_1 / 1007_Docetaxel_1 / 1015_CI-1040_2 / 1498_Selumetinib_2 / 1016_Temsirolimus_1 / 172_Embelin_2 / 59_WZ-1-84_3 / 282_Pelitinib_2 / 1377_Afatinib_1 DNArep / erk_mapk / erk_mapk / abl / cytoskeleton / erk_mapk / erk_mapk / tor / apop / other / egfr / egfr 17_78529723_C_G
7 GBP1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1007_Docetaxel_1 / 1015_CI-1040_2 / 182_Obatoclax Mesylate_2 / 167_OSU-03012_3 / 1062_Selumetinib_2 / 51_Dasatinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton / erk_mapk / apop / pi3k / erk_mapk / abl 3_55480738_A_T
8 ERLEC1_1 326_GSK690693_3 / 1011_Navitoclax_2 / 252_WZ3105_3 / 299_OSI-027_2 / 330_XMD13-2_3 / 312_Tivozanib_2 / 302_PI-103_3 / 222_BX-912_3 / 329_QL-XI-92_3 pi3k / apop / other / tor / other / rtk / pi3k / pi3k / rtk 10_52768593_C_G
9 SSH3_1 1372_Trametinib_1 / 1377_Afatinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1114_Cetuximab_1 / 1010_Gefitinib_1 / 1015_CI-1040_2 / 1378_Bleomycin(50uM)_1 erk_mapk / egfr / erk_mapk / erk_mapk / egfr / egfr / egfr / erk_mapk / DNArep 3_7680310_G_A
10 TRIP10_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1378_Bleomycin(50uM)_1 / 1054_Palbociclib_2 / 1007_Docetaxel_1 erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / erk_mapk / DNArep / cell_cyc / cytoskeleton 14_20381224_T_G
11 MAN1B1_5 1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 / 1015_CI-1040_2 / 1114_Cetuximab_1 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1026_Tanespimycin_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / other 19_57490144_T_A / 19_57473550_A_G / 19_57507480_A_G / 19_57455681_G_T / 19_57455765_G_A
12 CD151_2 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 172_Embelin_2 / 1060_PD0325901_2 / 1026_Tanespimycin_2 / 182_Obatoclax Mesylate_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / apop / erk_mapk / other / apop 3_3845235_C_T / 3_3845163_G_C
13 PDLIM7_1 1007_Docetaxel_1 / 159_HG6-64-1_3 / 1026_Tanespimycin_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1054_Palbociclib_2 / 1498_Selumetinib_2 / 1062_Selumetinib_2 cytoskeleton / erk_mapk / other / erk_mapk / erk_mapk / cell_cyc / erk_mapk / erk_mapk 16_84872374_G_C
14 GLIPR1_1 1372_Trametinib_1 / 1007_Docetaxel_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1054_Palbociclib_2 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1026_Tanespimycin_2 erk_mapk / cytoskeleton / erk_mapk / erk_mapk / cell_cyc / erk_mapk / erk_mapk / other 16_55398_G_T
15 GPR87_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1032_Afatinib_1 / 1378_Bleomycin(50uM)_1 erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / egfr / DNArep 19_15807367_G_T
16 SNAP25_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1032_Afatinib_1 / 1007_Docetaxel_1 erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / egfr / cytoskeleton 2_71424561_G_GT
17 FGFBP1_2 1372_Trametinib_1 / 1377_Afatinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1010_Gefitinib_1 / 1015_CI-1040_2 erk_mapk / egfr / erk_mapk / erk_mapk / egfr / egfr / erk_mapk 2_65069680_A_C / 17_81206909_A_C
18 CHN1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1015_CI-1040_2 / 1010_Gefitinib_1 erk_mapk / erk_mapk / egfr / erk_mapk / egfr / erk_mapk / egfr 17_81206909_A_C
19 ACSF2_4 1372_Trametinib_1 / 1526_Refametinib_3 / 1114_Cetuximab_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1377_Afatinib_1 / 1026_Tanespimycin_2 erk_mapk / erk_mapk / egfr / erk_mapk / egfr / egfr / other 2_71424561_G_GT / 2_71433365_T_TC / 2_71393433_A_G / 2_71428456_T_A
20 SNAPC3_1 1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1007_Docetaxel_1 erk_mapk / other / erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton 15_71256598_T_C
21 ZFP82_1 1377_Afatinib_1 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1114_Cetuximab_1 / 1526_Refametinib_3 / 1032_Afatinib_1 / 1010_Gefitinib_1 egfr / erk_mapk / erk_mapk / egfr / erk_mapk / egfr / egfr 3_33120406_C_T
22 OPHN1_1 1016_Temsirolimus_1 / 1007_Docetaxel_1 / 1372_Trametinib_1 / 1054_Palbociclib_2 / 1526_Refametinib_3 / 1019_Bosutinib_1 / 1026_Tanespimycin_2 tor / cytoskeleton / erk_mapk / cell_cyc / erk_mapk / abl / other 12_54002598_T_G
23 TNS3_1 1014_Refametinib_2 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1060_PD0325901_2 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk 7_47967711_A_T
24 P2RY6_5 1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1014_Refametinib_2 erk_mapk / erk_mapk / egfr / erk_mapk / egfr / erk_mapk 2_71424561_G_GT / 2_71399439_CTA_C / 2_71398637_G_A / 2_71393433_A_G / 2_71428456_T_A
25 SCO2_3 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1007_Docetaxel_1 / 1526_Refametinib_3 / 1170_CCT-018159_3 / 1014_Refametinib_2 other / erk_mapk / cytoskeleton / erk_mapk / other / erk_mapk X_14581235_C_G / X_14581237_T_G / X_55487442_C_G
26 KHSRP_1 302_PI-103_3 / 299_OSI-027_2 / 252_WZ3105_3 / 301_PHA-793887_3 / 330_XMD13-2_3 / 1248_Daporinad_3 pi3k / tor / other / cell_cyc / other / metabol 4_119158232_G_A
27 TTC3_1 1007_Docetaxel_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1114_Cetuximab_1 cytoskeleton / other / erk_mapk / erk_mapk / erk_mapk / egfr 12_66128870_G_A
28 STEAP1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / erk_mapk 17_50677651_A_G
29 RNF207_2 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1015_CI-1040_2 / 1026_Tanespimycin_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / other 9_134036501_T_G / 16_68564104_A_G
30 C16orf59_2 257_NPK76-II-72-1_3 / 1248_Daporinad_3 / 269_NSC-207895_3 / 265_Tubastatin A_3 / 275_I-BET-762_3 mitosis / metabol / p53 / chromatin / chromatin 2_217847583_C_T / 2_217847883_G_A
31 ICAM1_1 1372_Trametinib_1 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1526_Refametinib_3 / 159_HG6-64-1_3 erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk 8_12358868_A_G
32 POLE_1 1011_Navitoclax_2 / 269_NSC-207895_3 / 193_GW-2580_3 / 1012_Vorinostat_1 / 1248_Daporinad_3 apop / p53 / rtk / chromatin / metabol 2_217847583_C_T
33 MYT1_3 1011_Navitoclax_2 / 1248_Daporinad_3 / 269_NSC-207895_3 / 211_TL-2-105_3 / 326_GSK690693_3 apop / metabol / p53 / erk_mapk / pi3k 2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A
34 MMRN2_1 1377_Afatinib_1 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1114_Cetuximab_1 / 1498_Selumetinib_2 egfr / erk_mapk / erk_mapk / egfr / erk_mapk 19_15807367_G_T
35 ZNF420_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1007_Docetaxel_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton 6_53654807_C_T
36 ELOVL1_2 1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 / 1014_Refametinib_2 erk_mapk / erk_mapk / other / erk_mapk / erk_mapk 1_203683316_A_G / 1_203698281_T_C
37 CHGB_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 51_Dasatinib_1 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk 15_67236036_T_G
38 MLKL_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1026_Tanespimycin_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / other 17_80137479_A_T
39 FEZ2_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1007_Docetaxel_1 / 1239_YK-4-279_3 / 1060_PD0325901_2 erk_mapk / erk_mapk / cytoskeleton / other / erk_mapk X_108735142_T_G
40 ADNP2_1 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 other / erk_mapk / erk_mapk / erk_mapk 9_41294004_C_A
41 CES2_1 1498_Selumetinib_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1010_Gefitinib_1 erk_mapk / erk_mapk / erk_mapk / egfr 8_17085328_C_T
42 DDR1_2 1377_Afatinib_1 / 1010_Gefitinib_1 / 1032_Afatinib_1 / 1372_Trametinib_1 egfr / egfr / egfr / erk_mapk 2_174801578_A_G / 4_89936328_G_A
43 PTGR1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1014_Refametinib_2 erk_mapk / erk_mapk / other / erk_mapk 19_45698914_C_T
44 LIN7A_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 13_45541596_C_A
45 SYNCRIP_1 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 301_PHA-793887_3 / 222_BX-912_3 mitosis / other / cell_cyc / pi3k 4_87340676_A_C
46 EREG_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 17_50677651_A_G
47 C12orf57_1 1007_Docetaxel_1 / 1114_Cetuximab_1 / 1372_Trametinib_1 / 204_Tipifarnib_2 cytoskeleton / egfr / erk_mapk / other 1_103082763_C_G
48 PARP9_1 1377_Afatinib_1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 egfr / erk_mapk / erk_mapk / erk_mapk 4_185267219_TA_T
49 SLITRK3_1 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk / erk_mapk 8_378251_A_G
50 BIRC7_2 1372_Trametinib_1 / 1066_AZD6482_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / pi3k / erk_mapk / erk_mapk 17_78510525_G_A / 17_78507511_T_C
51 ID4_1 173_FH535_3 / 1526_Refametinib_3 / 182_Obatoclax Mesylate_2 / 1372_Trametinib_1 other / erk_mapk / apop / erk_mapk 4_9334816_T_C
52 NUCB2_1 1142_HG-5-113-01_2 / 1054_Palbociclib_2 / 182_Obatoclax Mesylate_2 / 1239_YK-4-279_3 abl / cell_cyc / apop / other 8_26370124_A_G
53 PDLIM1_2 1377_Afatinib_1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1010_Gefitinib_1 egfr / erk_mapk / erk_mapk / egfr 11_124186080_G_A / 11_124224942_C_A
54 RNF219_3 1011_Navitoclax_2 / 269_NSC-207895_3 / 230_GSK429286A_3 / 226_GSK1070916_2 apop / p53 / cytoskeleton / mitosis 10_31363289_T_C / 2_68528704_T_C / 16_60358945_T_C
55 CTRB2_1 1378_Bleomycin(50uM)_1 / 1242_(5Z)-7-Oxozeaenol_3 / 1372_Trametinib_1 / 1526_Refametinib_3 DNArep / other / erk_mapk / erk_mapk 4_37433902_C_T
56 RAB31_2 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk X_81277112_A_C / 6_32027037_A_C
57 INADL_2 1010_Gefitinib_1 / 1377_Afatinib_1 / 1032_Afatinib_1 egfr / egfr / egfr 3_58285236_T_C / 2_241246976_C_T
58 DPYSL4_5 1011_Navitoclax_2 / 269_NSC-207895_3 / 275_I-BET-762_3 apop / p53 / chromatin 2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A / 2_217847379_A_G / 2_217842134_T_C
59 TMEM71_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 8_12358868_A_G
60 TPD52L2_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 9_134036501_T_G
61 PDIA3_2 269_NSC-207895_3 / 1011_Navitoclax_2 / 193_GW-2580_3 p53 / apop / rtk 10_52768593_C_G / 15_19964850_A_G
62 KCNK6_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 17_81206909_A_C
63 CASP8AP2_2 1011_Navitoclax_2 / 326_GSK690693_3 / 269_NSC-207895_3 apop / pi3k / p53 6_109431362_C_A / 10_24584658_G_C
64 LIG1_2 1011_Navitoclax_2 / 269_NSC-207895_3 / 193_GW-2580_3 apop / p53 / rtk 2_217847583_C_T / 2_217848003_A_G
65 ARVCF_1 1526_Refametinib_3 / 1372_Trametinib_1 / 172_Embelin_2 erk_mapk / erk_mapk / apop 15_71256598_T_C
66 PPP1R13L_1 1011_Navitoclax_2 / 211_TL-2-105_3 / 254_Quizartinib_2 apop / erk_mapk / rtk 7_33099535_G_A
67 ELL2_1 1011_Navitoclax_2 / 1248_Daporinad_3 / 269_NSC-207895_3 apop / metabol / p53 6_32183680_C_G
68 TMEM74_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1378_Bleomycin(50uM)_1 erk_mapk / erk_mapk / DNArep 15_67236036_T_G
69 SH3KBP1_1 207_AS601245_3 / 172_Embelin_2 / 204_Tipifarnib_2 jnk_p38 / apop / other 8_12358868_A_G
70 AGXT2L2_4 1011_Navitoclax_2 / 193_GW-2580_3 / 269_NSC-207895_3 apop / rtk / p53 2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A / 2_217848559_G_A
71 FLNA_1 159_HG6-64-1_3 / 153_Midostaurin_2 / 51_Dasatinib_1 erk_mapk / rtk / abl 3_118902653_C_T
72 EVPL_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 erk_mapk / erk_mapk / egfr 15_84798628_G_A
73 ITPRIPL1_1 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 2_24209270_T_C
74 MFSD5_3 1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 erk_mapk / other / erk_mapk 10_96386941_T_G / 10_93374837_C_T / 12_9153310_A_C
75 IL31RA_1 180_Thapsigargin_3 / 1372_Trametinib_1 / 159_HG6-64-1_3 other / erk_mapk / erk_mapk 4_20727343_G_C
76 PTP4A3_1 1007_Docetaxel_1 / 1372_Trametinib_1 / 1526_Refametinib_3 cytoskeleton / erk_mapk / erk_mapk X_92201459_T_G
77 MMP14_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 15_99729430_G_C
78 CAND2_3 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk X_101102428_CT_C / X_101102205_C_G / X_101102212_T_C
79 ZNF292_5 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3 other / erk_mapk / erk_mapk 6_32027037_A_C / 12_130357070_A_C / 20_1445690_A_C / X_116441009_T_G / 5_40853381_T_G
80 EPSTI1_1 167_OSU-03012_3 / 1526_Refametinib_3 / 182_Obatoclax Mesylate_2 pi3k / erk_mapk / apop 2_226796327_T_C
81 CD97_5 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3 other / erk_mapk / erk_mapk 7_108514148_A_C / 12_108517007_T_G / 17_80137479_A_T / 5_141193109_A_G / 4_8036186_A_G
82 POLE4_5 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1007_Docetaxel_1 other / erk_mapk / cytoskeleton 2_218618671_A_C / 16_72107293_C_G / 11_47315255_C_G / 21_46116692_T_G / 1_220001162_G_T
83 ZDHHC5_2 1372_Trametinib_1 / 1498_Selumetinib_2 / 1526_Refametinib_3 erk_mapk / erk_mapk / erk_mapk 7_101136942_T_G / 16_89729370_A_C
84 CAV1_1 1011_Navitoclax_2 / 211_TL-2-105_3 / 193_GW-2580_3 apop / erk_mapk / rtk 10_133626829_C_T
85 PRDM15_1 1114_Cetuximab_1 / 1372_Trametinib_1 / 1526_Refametinib_3 egfr / erk_mapk / erk_mapk 5_181333681_C_T
86 TXNL4A_1 1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 erk_mapk / other / erk_mapk 11_124397016_A_G
87 PITX1_1 1268_XAV939_3 / 1372_Trametinib_1 / 1526_Refametinib_3 wnt / erk_mapk / erk_mapk 10_43373649_C_A
88 CDCA5_1 1011_Navitoclax_2 / 269_NSC-207895_3 apop / p53 2_217847583_C_T
89 S100A8_1 1377_Afatinib_1 / 1527_Pictilisib_2 egfr / pi3k 19_7746529_A_C
90 ZNF345_2 207_AS601245_3 / 1007_Docetaxel_1 jnk_p38 / cytoskeleton 6_53654807_C_T / 1_153772281_T_G
91 CXXC1_2 51_Dasatinib_1 / 1372_Trametinib_1 abl / erk_mapk 3_112199369_A_G / 2_119254595_G_A
92 ANO4_1 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 9_41294004_C_A
93 STAG2_1 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 3_10819431_A_G
94 PBX4_1 1011_Navitoclax_2 / 269_NSC-207895_3 apop / p53 1_101786406_G_A
95 RRM1_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 2_217847583_C_T
96 NUPL1_2 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 19_11666277_T_C / 10_31363289_T_C
97 MCFD2_2 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 1_161518073_C_T / 1_161518227_T_C
98 IKBKAP_1 1011_Navitoclax_2 / 269_NSC-207895_3 apop / p53 10_52768593_C_G
99 KHK_2 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 2_217847583_C_T / 2_217848003_A_G
100 SEMA4B_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 7_92469651_G_A
101 CEP41_1 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 13_36365551_C_T
102 DTX3L_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 4_185267219_TA_T
103 SMC2_1 1011_Navitoclax_2 / 269_NSC-207895_3 apop / p53 15_62657955_G_C
104 HDAC6_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 13_45503246_G_A
105 KDM3A_1 1060_PD0325901_2 / 207_AS601245_3 erk_mapk / jnk_p38 9_61211264_T_G
106 DCAKD_1 1011_Navitoclax_2 / 1248_Daporinad_3 apop / metabol 6_32183680_C_G
107 DUSP5_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 6_32183680_C_G
108 PRPF40A_2 301_PHA-793887_3 / 252_WZ3105_3 cell_cyc / other 4_189953012_G_A / 2_237772072_T_G
109 PPIB_4 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C / 15_59207967_A_G
110 ERAP2_2 1372_Trametinib_1 / 1026_Tanespimycin_2 erk_mapk / other 5_96986715_C_T / 5_96917400_T_C
111 BAALC_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 15_67236036_T_G
112 CACNA2D2_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 15_67236036_T_G
113 CNPY4_1 1377_Afatinib_1 / 288_WHI-P97_3 egfr / other 17_48728228_G_A
114 ANO5_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 12_9427796_G_T
115 KLK6_2 1372_Trametinib_1 / 288_WHI-P97_3 erk_mapk / other 4_48170249_G_A / 4_48170201_C_T
116 TNIP2_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 7_33099535_G_A
117 KCNJ11_4 1011_Navitoclax_2 / 293_Amuvatinib_2 apop / rtk 2_217847583_C_T / 2_217847883_G_A / 2_217848559_G_A / 2_217848003_A_G
118 MED14_1 193_GW-2580_3 / 269_NSC-207895_3 rtk / p53 2_95859911_C_T
119 PDGFC_3 1026_Tanespimycin_2 / 1016_Temsirolimus_1 other / tor 5_150896225_C_T / 5_150898617_C_T / 5_150903222_T_C
120 SLFN12_2 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 1_241723452_T_C / 1_241723462_A_G
121 PDP1_5 1372_Trametinib_1 / 1377_Afatinib_1 erk_mapk / egfr 15_25189495_C_T / 15_25194819_G_A / 15_25199636_G_A / 4_87811722_A_G / 15_25185507_G_A
122 IER5L_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 9_34623341_A_G
123 ABCA5_2 1372_Trametinib_1 / 1026_Tanespimycin_2 erk_mapk / other 17_50677651_A_G / 17_78529677_G_C
124 CABP7_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 1_46344858_A_G
125 FCRLB_5 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 2_118982373_A_G / 17_81276033_A_C / X_132085721_T_C / 15_82463815_A_C / 9_41189241_T_C
126 TIGD3_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 5_135888024_G_T
127 ZNF295_1 159_HG6-64-1_3 / 1526_Refametinib_3 erk_mapk / erk_mapk 11_113854221_T_C
128 PLD2_1 1114_Cetuximab_1 / 288_WHI-P97_3 egfr / other 15_84407910_G_A
129 CD55_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 5_113384951_C_A
130 QKI_3 1242_(5Z)-7-Oxozeaenol_3 / 1007_Docetaxel_1 other / cytoskeleton 6_87514446_T_C / 6_87612279_G_A / 6_87511385_T_C
131 MZT1_1 1011_Navitoclax_2 / 269_NSC-207895_3 apop / p53 10_31363289_T_C
132 SEMA7A_1 1372_Trametinib_1 / 182_Obatoclax Mesylate_2 erk_mapk / apop 22_24253656_C_G
133 ROR2_1 1372_Trametinib_1 / 1377_Afatinib_1 erk_mapk / egfr 13_44436731_C_T
134 TRIP6_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 17_78529677_G_C
135 C14orf142_1 1242_(5Z)-7-Oxozeaenol_3 / 1378_Bleomycin(50uM)_1 other / DNArep 11_66055499_T_G
136 ZEB1_2 1377_Afatinib_1 / 1032_Afatinib_1 egfr / egfr 3_58285236_T_C / 9_41905830_C_G
137 NIP7_2 344_THZ-2-49_3 / 1007_Docetaxel_1 cell_cyc / cytoskeleton 9_33529025_G_T / 9_122724363_T_G
138 GNAO1_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 10_133626013_G_A
139 FGF9_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 13_32131648_A_G
140 SERINC3_1 1114_Cetuximab_1 / 1526_Refametinib_3 egfr / erk_mapk 2_25980839_T_G
141 RSBN1_1 1026_Tanespimycin_2 / 1372_Trametinib_1 other / erk_mapk 2_127286836_G_C
142 ARVCF_1 1011_Navitoclax_2 / 193_GW-2580_3 apop / rtk 10_133626829_C_T
143 DTL_1 269_NSC-207895_3 / 326_GSK690693_3 p53 / pi3k 2_29239654_G_A
144 SRSF7_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 5_181333681_C_T
145 IFIT5_2 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 6_169632990_G_A / 6_169665646_G_A
146 NARF_1 1007_Docetaxel_1 / 1526_Refametinib_3 cytoskeleton / erk_mapk 12_32328439_A_C
147 CASP8_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 17_75904383_G_C
148 IL17RB_1 1239_YK-4-279_3 / 1526_Refametinib_3 other / erk_mapk 19_44506064_G_T
149 SLC15A2_1 1377_Afatinib_1 egfr 2_174801578_A_G
150 SAR1B_1 193_GW-2580_3 rtk 5_155013898_A_G
151 TTC1_1 1011_Navitoclax_2 apop 5_155013898_A_G
152 CRP_2 165_DMOG_3 other 9_129834783_A_C / 17_69536247_A_G
153 GGCX_1 1011_Navitoclax_2 apop 19_39875355_A_T
154 SOX9_1 1066_AZD6482_2 pi3k 11_1092981_A_C
155 DLX5_3 1011_Navitoclax_2 apop 2_217847883_G_A / 2_217848003_A_G / 2_217847583_C_T
156 SNRNP25_3 1011_Navitoclax_2 apop 2_217847883_G_A / 2_217847583_C_T / 2_217848003_A_G
157 UHRF1BP1L_1 29_AZ628_3 erk_mapk 2_113594958_C_G
158 PAPD4_1 1011_Navitoclax_2 apop 19_54274840_G_A
159 ADAMTS14_1 1011_Navitoclax_2 apop 19_52554226_G_A
160 FAT2_1 1377_Afatinib_1 egfr 19_15807367_G_T
161 ZNF750_2 1377_Afatinib_1 egfr 19_15807367_G_T / 19_15794719_C_A
162 BTG2_1 1026_Tanespimycin_2 other 6_34872273_T_G
163 PIGB_4 1011_Navitoclax_2 apop 15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C / 15_59207967_A_G
164 WHAMM_4 1011_Navitoclax_2 apop 15_59207967_A_G / 15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C
165 PELI2_2 1011_Navitoclax_2 apop 9_114169457_C_T / 17_68420216_C_T
166 RPS5_1 302_PI-103_3 pi3k 10_89339873_T_C
167 DALRD3_1 1011_Navitoclax_2 apop 1_244857989_TA_T
168 ANKRD22_1 1372_Trametinib_1 erk_mapk 17_81206909_A_C
169 AGBL4_5 1011_Navitoclax_2 apop 2_217847883_G_A / 2_217848003_A_G / 2_217847583_C_T / 2_217842134_T_C / 2_217847379_A_G
170 DCUN1D2_1 1011_Navitoclax_2 apop 10_31363289_T_C
171 RAP2A_1 1011_Navitoclax_2 apop 10_31363289_T_C
172 TEX30_1 1011_Navitoclax_2 apop 10_31363289_T_C
173 CPNE8_1 1011_Navitoclax_2 apop X_24055660_C_A
174 IFIT3_1 1011_Navitoclax_2 apop 18_50806833_C_G
175 KCNMB2_1 1011_Navitoclax_2 apop 18_50806833_C_G
176 TRIM21_1 1011_Navitoclax_2 apop 18_50806833_C_G
177 NAP1L4_1 1011_Navitoclax_2 apop 12_27969552_T_A
178 GALNT3_1 1377_Afatinib_1 egfr 3_7680310_G_A
179 EVL_1 1011_Navitoclax_2 apop 7_33264495_A_G
180 TSPAN8_1 1242_(5Z)-7-Oxozeaenol_3 other 14_59565278_G_A
181 RUNDC3B_1 1011_Navitoclax_2 apop 4_68236279_G_GA
182 CCDC113_1 1054_Palbociclib_2 cell_cyc 16_67199408_A_C
183 PIAS2_2 1526_Refametinib_3 erk_mapk 18_49837560_A_G / 18_49837561_G_C
184 ALG14_1 1023_GW441756_3 rtk 12_27755086_G_GA
185 TAF11_1 1011_Navitoclax_2 apop 15_84516674_T_G
186 KCNK9_1 193_GW-2580_3 rtk 10_28880454_A_G
187 LRRC8A_1 1377_Afatinib_1 egfr 5_173158713_A_G
188 TMEM151B_1 1372_Trametinib_1 erk_mapk 9_67920363_C_T
189 C10orf76_1 1007_Docetaxel_1 cytoskeleton 2_169557387_G_GA
190 NXNL2_1 1007_Docetaxel_1 cytoskeleton 12_54002598_T_G
191 TCEB3_1 330_XMD13-2_3 other 14_67333008_A_G
192 CPEB2_2 266_Zibotentan_2 other 8_22102127_A_G / 8_22102128_C_T
193 TUBB_1 193_GW-2580_3 rtk 1_101786406_G_A
194 UBE2H_1 1011_Navitoclax_2 apop 2_9279286_C_T
195 TM9SF4_1 1526_Refametinib_3 erk_mapk 9_41294004_C_A
196 ZNF250_1 1011_Navitoclax_2 apop 5_135888024_G_T
197 ARSD_1 269_NSC-207895_3 p53 1_101786406_G_A
198 ZBED5_5 1026_Tanespimycin_2 other 5_176529597_A_C / 14_69704655_C_T / 11_62807431_T_G / 7_99486962_A_C / 5_138430313_A_C
199 TEAD3_3 1011_Navitoclax_2 apop 18_166710_TTAAAA_T / 18_166819_T_C / 18_264012_G_A
200 PAICS_1 1377_Afatinib_1 egfr 19_50637249_G_A
201 SDSL_1 1026_Tanespimycin_2 other 3_31664157_C_T
202 SP140L_1 1011_Navitoclax_2 apop 19_9857463_G_A
203 VEZF1_1 1011_Navitoclax_2 apop 4_122258745_C_T
204 TSR2_2 1011_Navitoclax_2 apop 8_109271027_T_C / 8_109271124_T_G
205 LRFN5_1 1011_Navitoclax_2 apop 10_3165440_A_G
206 HMOX1_3 1026_Tanespimycin_2 other 1_183239405_G_A / 20_39018962_A_C / 2_86785910_T_G
207 OAF_2 1011_Navitoclax_2 apop 9_83978162_A_T / 9_83976942_T_C
208 C1orf198_1 193_GW-2580_3 rtk 20_6215106_T_C
209 RNF145_1 193_GW-2580_3 rtk 15_65447029_G_A
210 TFDP1_2 1011_Navitoclax_2 apop 10_31363289_T_C / 16_60358945_T_C
211 TRIM33_5 1026_Tanespimycin_2 other 5_176575310_A_C / 6_136362716_T_G / 4_78315728_T_G / 22_42516026_A_G / 12_14806481_T_G
212 BRD1_1 147_NSC-87877_3 other 5_154002958_G_A
213 RAB18_1 1011_Navitoclax_2 apop 3_146194512_C_T
214 DOK6_1 1011_Navitoclax_2 apop 18_12840880_T_C
215 TMEM132D_1 1011_Navitoclax_2 apop 1_89592683_G_GT
216 RBKS_1 1011_Navitoclax_2 apop 7_140126550_T_A
217 SDPR_1 1372_Trametinib_1 erk_mapk 15_23364667_T_G
218 HADHB_3 1011_Navitoclax_2 apop 19_48944320_G_A / 19_48944456_G_A / 19_48942517_C_T
219 RAB2B_1 1011_Navitoclax_2 apop 15_20251568_G_A
220 CLSPN_2 1011_Navitoclax_2 apop 15_62651935_A_G / 15_62657955_G_C
221 LRCH2_1 1372_Trametinib_1 erk_mapk 19_1825787_T_TA
222 RIC8B_1 1011_Navitoclax_2 apop 3_39412024_A_G
223 SNX17_1 1026_Tanespimycin_2 other 17_43879789_T_G
224 HPS1_3 1026_Tanespimycin_2 other 9_136463607_G_A / 9_136476782_G_A / 9_136453326_A_G
225 TNNT3_1 1377_Afatinib_1 egfr 2_226796327_T_C
226 MPHOSPH9_1 257_NPK76-II-72-1_3 mitosis 14_104949986_T_C
227 PCDH7_1 1372_Trametinib_1 erk_mapk 11_64284449_A_C
228 NSL1_1 193_GW-2580_3 rtk 3_75665457_C_T
229 ALG9_1 1011_Navitoclax_2 apop 14_76498312_C_T
230 PDE12_1 1006_Cytarabine_1 DNArep 1_161518073_C_T
231 PAPSS2_1 173_FH535_3 other 1_485270_G_A
232 ZFHX2_1 1011_Navitoclax_2 apop 9_27567147_C_T
233 TFG_2 1011_Navitoclax_2 apop X_16150554_T_C / X_16150344_T_C
234 IL15RA_1 1011_Navitoclax_2 apop 22_36566306_C_G
235 MBTD1_1 1248_Daporinad_3 metabol 22_36566306_C_G
236 TMPRSS4_1 1372_Trametinib_1 erk_mapk 11_18484085_G_A
237 APBB1_1 1011_Navitoclax_2 apop 7_117548606_ATG_A
238 MAD2L2_1 1011_Navitoclax_2 apop 7_117548606_ATG_A
239 MAP4_1 1011_Navitoclax_2 apop 7_33099535_G_A
240 GLTP_1 1377_Afatinib_1 egfr 2_182994745_T_C
241 CECR2_1 1011_Navitoclax_2 apop 15_30596563_A_G
242 RUFY1_1 1011_Navitoclax_2 apop 17_73212821_T_C
243 LRRN1_3 1372_Trametinib_1 erk_mapk 10_26492426_T_C / 4_654142_G_A / 14_67347493_A_C
244 ATRIP_1 1026_Tanespimycin_2 other 19_815835_G_A
245 NADKD1_1 1011_Navitoclax_2 apop 3_16323447_C_T
246 DAPL1_5 1026_Tanespimycin_2 other 15_78923063_A_C / 1_2588455_T_G / 20_32797074_C_A / 14_69704655_C_T / 17_7701545_A_C
247 HSD17B10_1 1011_Navitoclax_2 apop 5_24511259_C_T
248 CTSL1_5 1526_Refametinib_3 erk_mapk 7_6857531_A_G / 10_62069760_A_C / 17_80137479_A_T / X_52907336_A_C / 3_62493670_T_G
249 PPM1F_2 1031_Elesclomol_2 other 14_72893955_C_G / 16_29382935_T_G
250 SERPINB8_1 1248_Daporinad_3 metabol 6_69361281_G_A
251 LEPREL4_1 1011_Navitoclax_2 apop 19_11116804_A_C
252 HIRA_1 225_Genentech Cpd 10_3 mitosis 9_41341340_C_T
253 MET_2 1011_Navitoclax_2 apop 10_133626013_G_A / 10_133626012_T_A
254 ST18_2 1011_Navitoclax_2 apop 10_133626012_T_A / 10_133626013_G_A
255 IFI35_1 1372_Trametinib_1 erk_mapk 12_15589379_GA_G
256 CNKSR3_1 1166_QL-VIII-58_3 tor 17_78539866_T_C
257 NFKBIZ_1 1372_Trametinib_1 erk_mapk 6_47579334_T_TAA
258 TFPI_1 1372_Trametinib_1 erk_mapk 6_47579334_T_TAA
259 PDIA6_1 1011_Navitoclax_2 apop 11_17498150_C_G
260 RSF1_3 1026_Tanespimycin_2 other 8_143870873_T_G / 1_54986510_A_C / 12_14806481_T_G
261 MYO1E_2 1372_Trametinib_1 erk_mapk 15_25170856_G_A / X_153670877_G_T
262 UBAP1_1 1372_Trametinib_1 erk_mapk 5_31510999_G_T
263 GFER_1 1026_Tanespimycin_2 other 2_85639407_A_C
264 C17orf75_1 211_TL-2-105_3 erk_mapk 6_32183680_C_G
265 TTC9B_1 1011_Navitoclax_2 apop 17_74541739_G_A
266 FAM198B_1 211_TL-2-105_3 erk_mapk 6_106519310_A_C
267 DCTD_1 1026_Tanespimycin_2 other 8_7429219_C_T
268 ZSCAN16_1 1011_Navitoclax_2 apop 7_26185482_G_A
269 CCDC14_2 1372_Trametinib_1 erk_mapk 7_33357933_C_A / 9_33529025_G_T
270 TRIP11_1 1011_Navitoclax_2 apop 1_230792766_C_G
271 NKAIN2_1 1011_Navitoclax_2 apop 1_169804019_T_C
272 NT5E_1 1011_Navitoclax_2 apop 1_169804019_T_C
273 PPP1R14A_5 196_Phenformin_3 metabol 15_57438247_A_C / 5_76209739_T_G / X_149774713_G_C / 1_35479062_T_G / 9_109406442_T_C
274 CDH2_1 1241_CHIR-99021_3 wnt 1_155060858_G_A
275 EMC3_1 151_QS11_3 other 1_197039467_A_C
276 NCAPG2_1 6_PHA-665752_3 rtk 1_149021276_A_C
277 OR13H1_2 166_FTI-277_3 other 2_201728736_A_G / 2_201723527_C_T
폐암(lung) 약물에 대한 바이오 마커의 반응성 검증 결과
No. FRH Var_Exp(pval) Var_Drug(pval) Exp_Drug(pval) Ave_VarDrug(pval) Rank
1 POLR3K_5 1.67E-06 7.55E-05 / 9.21E-05 / 0.000406169 / 0.000572894 / 0.000596706 / 0.000830024 / 0.000897369 / 0.000943017 / 0.00100282 / 0.001405937 / 0.001436612 / 0.001463281 / 0.001585317 / 0.00161475 / 0.001676489 / 0.001964123 / 0.00196632 / 0.002055398 / 0.002082114 / 0.002155282 / 0.002396859 / 0.00278744 / 0.002914256 / 0.002947382 / 0.003272641 / 0.003463499 / 0.00367462 / 0.00367676 / 0.003769026 / 0.003782462 / 0.004059938 / 0.004512707 / 0.005161898 / 0.005787569 / 0.006314892 / 0.006945435 / 0.008072051 / 0.008410403 / 0.008931324 0.001531019 / 0.057569018 / 0.249595562 / 0.085576027 / 0.000387243 / 1.59E-05 / 0.059525284 / 0.863014405 / 0.249659436 / 0.124147024 / 0.000281163 / 7.11E-06 / 0.019500847 / 0.695397999 / 0.001918781 / 0.086727092 / 0.023202587 / 0.000441974 / 0.000350217 / 6.89E-05 / 0.594643715 / 0.036578315 / 0.000474321 / 0.011974306 / 0.079370245 / 0.828009563 / 0.010696272 / 0.005232793 / 0.582545022 / 0.058088741 / 0.00262003 / 0.049789754 / 0.228619231 / 0.001174198 / 7.02E-05 / 1.63E-06 / 0.295541863 / 7.79E-06 / 3.75E-05 2.97E-03 39
2 FAM114A1_1 0.0000025505 0.0042694104092888974 / 0.00020876871631167866 / 0.0007568114081113288 / 0.0035305946391629545 / 0.008363870991709823 / 1.4383640936438872e-05 / 7.009824754153582e-05 / 0.0035938658204617215 / 0.006293754132220173 / 0.0032074496683567847 / 0.020401954406182556 / 0.0003542511072244001 1.985359164220784e-08 / 1.9619211144338805e-07 / 1.1786246361826978e-07 / 1.2984459856816525e-07 / 6.679222855070028e-07 / 7.60276325486698e-06 / 4.381181635105041e-08 / 3.0395531368179466e-06 / 3.92186793718892e-06 / 1.4410681857864534e-05 / 2.2310227467645046e-05 / 6.449074536371506e-07 0.004255434 12
3 AVPI1_1 0.0000003933 0.0006396902026437372 / 0.0035535295006568564 / 0.004142441090345042 / 0.008737166819403942 / 0.005365726625203914 / 0.016265715773138612 / 0.041737910661353794 / 0.03071155447434498 / 0.012033224729341468 / 0.013915501344307473 / 0.009991096973902677 / 0.01939906554836552 8.724099353866297e-18 / 4.327010736165959e-17 / 8.775781672799915e-14 / 3.5651532383955547e-13 / 2.396709082503607e-12 / 5.521480171031492e-10 / 1.2559804874872373e-08 / 2.0783114956254993e-07 / 4.311397020221965e-08 / 2.2998188297812146e-05 / 5.132866263479021e-07 / 2.0389575690868755e-07 0.013874385 12
4 S100A11_1 0.0000007141 0.0002735997430699673 / 0.006564850275482538 / 0.00042414739039363294 / 0.029067524880234556 / 0.0227837453875734 / 0.0013348733587389963 / 0.025661191456139584 / 0.030326580226023813 / 0.01355699403064558 / 0.004313726310163241 / 0.0095400572561103 / 0.04535245933148631 6.393329432968863e-16 / 1.2307435361378187e-13 / 2.466858890049804e-13 / 5.545342625838226e-09 / 1.0380326612394311e-08 / 2.3437239888960063e-09 / 1.3417028235666536e-07 / 4.443975040006529e-07 / 9.063384713333984e-07 / 1.1118101978147603e-06 / 2.049520010016173e-06 / 4.414454919747786e-06 0.015766646 12
5 TMEM92_2 0.0000000001 8.127905920870596e-06 / 0.03825717382100051 / 0.03457460632857845 / 0.004853137512524773 / 0.03388689864411195 / 0.008814758212945951 / 0.03578088316319923 / 0.006217130934294085 / 0.00017355910676635736 / 0.0280335961707743 / 0.0017388474926662016 / 0.00012460830831951075 2.4261531255663892e-11 / 5.0311269179717914e-11 / 2.4975316917871734e-10 / 2.042638151066576e-07 / 1.5566664880019958e-10 / 5.680894385767319e-06 / 1.6699000588343938e-06 / 6.566036837900111e-06 / 3.420597261413642e-07 / 8.237906153677492e-07 / 9.263610563311242e-07 / 1.2428063696083114e-06 0.016038611 12
6 ATP6V0B_1 0.0000017465 0.00016551876926533193 / 0.015335407229032524 / 0.0076626373197674 / 0.028777417252359768 / 0.026082796942956787 / 0.0389316131443371 / 0.0004915314263603532 / 0.0014839424825817675 / 0.022837697585243923 / 0.01178531426696526 / 0.00988329756179177 / 0.031727625216694644 2.401602140750141e-13 / 4.8650677089433124e-11 / 3.9493836034696935e-10 / 7.33482261725945e-09 / 2.8535418288695915e-08 / 2.096326058421669e-09 / 1.5659535702420375e-08 / 3.964614244828257e-07 / 1.7237698783914587e-07 / 3.2415943673340482e-06 / 6.164017172502494e-08 / 3.4316628105398186e-07 0.016263733 12
7 GBP1_1 0.0000405829 0.04015481753439807 / 0.018576825788521975 / 0.01852560134227437 / 0.002373869363376313 / 0.02782754766981264 / 0.002415619395480455 / 0.011881237105466349 / 0.00033563208340305035 / 0.005055991739999371 / 0.008903270762925434 1.187415764241114e-11 / 6.095615889440819e-11 / 1.917288218821707e-12 / 5.619391245841771e-08 / 1.1719944005143196e-08 / 1.0794280052002033e-07 / 5.9596304962709845e-08 / 0.0004931619081689741 / 9.495988028273389e-08 / 1.1666929391578053e-06 0.013605041 10
8 ERLEC1_1 0.0000005719 3.075536174342061e-06 / 0.012665982332335715 / 2.1913337236976437e-05 / 7.482707136703458e-05 / 2.6075431224558473e-05 / 5.690512097896811e-05 / 0.0020110917770508187 / 0.0009108241993284896 / 9.402887850421925e-06 8.155050086866359e-08 / 8.547376478456365e-07 / 4.650557832871856e-07 / 1.979425060398104e-07 / 9.659100942891217e-07 / 1.5727836576660756e-05 / 2.4902482384647638e-06 / 5.963679135141154e-06 / 0.0002870787007736368 0.001753344 9
9 SSH3_1 0.0000007635 0.0035447981156988204 / 0.0020476470911988563 / 0.0043734414976099745 / 0.00442890244448457 / 0.0016646475834734644 / 0.003469684588834184 / 0.016258281480713958 / 0.007203498668728194 / 0.008481086009715616 1.2839817776716313e-11 / 2.1456295745112202e-09 / 7.804965919854057e-11 / 1.0846113597262452e-10 / 8.402308355591066e-09 / 4.0629325207940226e-07 / 3.407462995284017e-05 / 4.726367578576213e-06 / 2.5541465321521183e-06 0.00571911 9
10 TRIP10_1 0.0000173218 0.008943680317061822 / 0.0013412546793620756 / 0.0015773645986452735 / 0.007477694270383053 / 0.03117319702966703 / 0.03615921936711382 / 0.0031899243253359325 / 0.01485798676987582 / 0.03709204807398679 2.967675338863489e-16 / 1.3369912839925863e-16 / 9.67218561771649e-13 / 1.6290794365229653e-10 / 7.687956044278108e-10 / 4.534964360985728e-09 / 5.405201490429158e-09 / 7.483583479891572e-09 / 6.363635419128828e-06 0.01575693 9
11 MAN1B1_5 0.0000014304 0.0023856498203327875 / 7.812266726494329e-05 / 0.027952944492863622 / 0.005617959119750928 / 0.002644793270745064 / 0.012381465875087235 / 0.0074542403283965625 / 0.001546432706758083 1.868937111544232e-10 / 1.6531442166915098e-08 / 9.414450468098132e-09 / 7.030425208487326e-08 / 4.773344609707843e-08 / 3.1813403816802826e-08 / 1.2054478070790373e-06 / 5.5556733765270095e-06 0.007507701 8
12 CD151_2 0.0000016613 0.002828971924250992 / 0.0020308786555996105 / 0.0037139272628794475 / 0.0008147078915095311 / 0.0027987535750038264 / 0.03156448872153919 / 0.006216893575679977 / 0.012774860953989628 1.3495328256839188e-12 / 1.6512296821172123e-12 / 3.6414648280531383e-13 / 2.006846342245524e-10 / 9.201808809340132e-08 / 5.931180856539697e-07 / 3.000290377999784e-07 / 5.940973440824346e-07 0.007842935 8
13 PDLIM7_1 0.0000151792 0.0017419308016053887 / 0.01703591045996455 / 0.010263742478054323 / 0.0074877120166343125 / 0.003951752871247063 / 0.023461658690951844 / 0.0007060714810871347 / 0.00993017974219656 1.4890466266195927e-09 / 1.3930872632280484e-10 / 4.042121027066677e-08 / 5.515991658674008e-07 / 3.206759648352692e-09 / 7.38168534365637e-08 / 1.2279749259117268e-08 / 1.6868345203620706e-07 0.00932237 8
14 GLIPR1_1 0.0000014611 0.008133825444941598 / 0.0005214752415830771 / 0.01773178574837757 / 0.009430350367584172 / 0.01955380058568292 / 0.003589646250229098 / 0.0015918099299812008 / 0.021268808314233105 1.4019555545362636e-10 / 1.3355121304727163e-10 / 5.96825464847569e-10 / 7.437295967997082e-09 / 2.751586429438836e-09 / 5.123469233147485e-08 / 4.827912592803016e-07 / 9.24174412768079e-06 0.010227688 8
15 GPR87_1 0.0000006448 0.0076251167073391945 / 0.0028222416161458853 / 0.033262979309241485 / 0.0006381430782712855 / 0.0019094505299096247 / 0.018260880298473985 / 0.003923489922251829 / 0.014606068770244599 7.534055709544274e-17 / 2.585655261990035e-15 / 5.2335156402490275e-15 / 2.4905394673635635e-09 / 2.579143491051842e-10 / 3.3024470123206265e-08 / 2.0302747016952384e-07 / 3.115039621495257e-06 0.010381046 8
16 SNAP25_1 0.0000076174 0.0018807133849514282 / 0.0021339409269866432 / 0.008547140700416327 / 0.007837425491160097 / 0.0018204809165742553 / 0.01250093546784304 / 0.029444897497836964 / 0.025484654242891817 1.4208036186314184e-16 / 1.5507536243084707e-13 / 1.696952191969015e-11 / 1.009604302429168e-09 / 1.0410206618966501e-09 / 1.850497353460836e-09 / 1.0634082068029867e-08 / 1.0722107820456968e-07 0.011206274 8
17 FGFBP1_2 0.0000000001 0.00017601864871485512 / 0.0005070210241593581 / 0.004411629733717425 / 0.008689109920315017 / 0.00019506735122442717 / 0.009640097626965513 / 0.006852417553255793 1.9060720081271283e-13 / 3.122850645863472e-09 / 4.1994336271257894e-10 / 6.0155643158720954e-09 / 3.843362175544889e-08 / 8.712480724022447e-06 / 1.9248384673484406e-07 0.004353052 7
18 CHN1_1 0.0000025565 0.0014573918997663137 / 0.008577741421710208 / 0.001198103041045066 / 0.001533522936452515 / 0.0033634941504627697 / 0.010785244262186303 / 0.0373128898832142 6.175453097411747e-15 / 1.0898537184801719e-12 / 4.243100156030503e-12 / 2.3893328777750658e-08 / 3.7113695617625286e-08 / 1.3950404315566743e-06 / 4.353340320251518e-07 0.009175484 7
19 ACSF2_4 0.0000126680 0.002287441661560721 / 0.002739732144211229 / 0.010839213238666172 / 0.02699935544242534 / 0.006587582753649601 / 0.020104758213330888 / 0.0037867420062336647 1.6018264558328353e-11 / 1.350522100376996e-10 / 3.533719025417417e-08 / 9.421341247634894e-07 / 6.358471973834479e-06 / 0.0005708652264651822 / 2.8573976842147612e-05 0.010477832 7
20 SNAPC3_1 0.0000014845 0.003808062774578335 / 0.03330161757206289 / 0.001267397044740127 / 0.025490833026200553 / 0.005752102707973715 / 0.010531169902390105 / 0.02097227539629169 4.138352317586387e-12 / 6.324952413663082e-12 / 2.3039595587795142e-11 / 4.135749382360492e-09 / 2.943942798609411e-09 / 4.785025404402047e-07 / 8.45468021727955e-07 0.014446208 7
21 ZFP82_1 0.0000002911 0.026193133649308403 / 0.002880197932827539 / 0.000892065314189748 / 0.03621760269335816 / 0.001409066709832824 / 0.03632632282612366 / 0.001597966657771602 2.1821058503470977e-07 / 2.1345284484994668e-07 / 1.6940360882868594e-06 / 2.332116712137168e-06 / 7.078139307433867e-06 / 4.932653487474453e-06 / 5.57905665828971e-06 0.015073765 7
22 OPHN1_1 0.0002612099 0.04894666674267963 / 0.003544372498506248 / 0.03445218818410945 / 0.029417648259261447 / 0.01144054174070861 / 0.030599292085887794 / 0.003150128220025032 2.2816161503286945e-09 / 5.483877356966662e-07 / 6.645530643543907e-07 / 1.1508399694576279e-07 / 2.1220867950204813e-06 / 1.0055030736784958e-05 / 8.336038812610863e-05 0.023078691 7
23 TNS3_1 0.0000006277 0.009569659528755218 / 0.0013302955859364471 / 0.0037548210952919408 / 0.0024792131341982242 / 0.003608716025393357 / 0.002638008434399487 8.722976186020636e-08 / 1.7164630812419945e-08 / 1.770632094332526e-08 / 1.9486556735289747e-07 / 4.0623560474101545e-07 / 5.860863385843348e-07 0.003896786 6
24 P2RY6_5 0.0000010436 0.0009804545262469449 / 0.0013446510229950341 / 0.003789065107490644 / 0.006218322225340153 / 0.03645229771138508 / 0.01562975702849699 1.576709465685621e-13 / 2.5331252718662176e-10 / 2.3521007770880894e-07 / 2.3770553645092087e-10 / 1.368096065972398e-07 / 2.5418800842381177e-07 0.010735758 6
25 SCO2_3 0.0000000001 0.01546077257784758 / 0.001964618656338199 / 0.0033965914999294854 / 0.012145502525993949 / 0.030055718710212946 / 0.013950769826858294 8.014599938246778e-09 / 1.8636695061114395e-08 / 3.705794897358954e-08 / 4.2936074352856663e-07 / 5.584053250118188e-05 / 2.397206724754045e-07 0.012828996 6
26 KHSRP_1 0.0000003011 0.010352775099646664 / 0.019182484865138457 / 0.015100022601522628 / 0.01700255170966236 / 0.023101003520372643 / 0.006776149448547382 2.8490498620729386e-09 / 5.206538616416615e-10 / 1.4824605802962609e-08 / 7.704856226971619e-07 / 5.512137468127689e-07 / 3.2143315687611383e-06 0.015252498 6
27 TTC3_1 0.0000002043 0.021976203067763718 / 0.014404186233262522 / 0.010065328958198384 / 0.005185630347493037 / 0.01771094219397329 / 0.026010950792548747 1.903714561147216e-10 / 1.8998104659295357e-09 / 8.134060967771899e-10 / 7.905696358239668e-09 / 1.7016664284191773e-06 / 2.3041895625093597e-07 0.015892207 6
28 STEAP1_1 0.0000029634 0.013036283678806082 / 0.015688398206555057 / 0.006349160970663491 / 0.03777942745740614 / 0.010550376036332488 / 0.017877825906191358 6.761435756061347e-12 / 2.4207465935628376e-11 / 3.564533224675541e-12 / 4.401553310565403e-08 / 1.2935469598692122e-07 / 1.118837878226449e-05 0.016880245 6
29 RNF207_2 0.0000000000 0.010918237443275771 / 0.010043999800272532 / 0.007055519329675997 / 0.027127865042923947 / 0.036896549219609824 / 0.015551929442979676 2.026443768844747e-13 / 1.0452530817759512e-11 / 3.4953412148396826e-12 / 2.417587221451319e-08 / 4.833952724825644e-07 / 6.916720467647325e-07 0.01793235 6
30 C16orf59_2 0.0000011638 0.0017105849166402373 / 0.008006011161483364 / 2.877198249929341e-05 / 0.00044269902702600075 / 0.0035960656357070827 8.710873698386588e-07 / 1.6466535184566052e-06 / 3.1826237601737307e-06 / 1.5852069704631895e-05 / 5.3568783395819636e-05 0.002756827 5
31 ICAM1_1 0.0000008958 0.0006371740222421855 / 0.0004238045362036801 / 0.004627658102704232 / 0.0017187301776334363 / 0.0141342657951169 5.301958232122965e-10 / 5.691310460319534e-10 / 9.501545566679268e-08 / 7.484161653079297e-07 / 1.0741352344507851e-05 0.004308327 5
32 POLE_1 0.0000006233 0.00020876871631167866 / 1.4383640936438872e-05 / 0.010067369603256736 / 0.012703084299864359 / 0.0035305946391629545 4.564149862726603e-11 / 4.031853969284765e-09 / 2.1715096143998947e-09 / 5.185675527716179e-08 / 9.417769469553245e-08 0.00530484 5
33 MYT1_3 0.0000018757 0.0003180382059133217 / 0.008006011161483364 / 2.877198249929341e-05 / 0.022477574071905464 / 0.002087164867003088 1.3185457834679754e-09 / 1.0046430313676016e-07 / 8.61285349137364e-07 / 5.400726736519221e-07 / 1.926503424303301e-05 0.006583512 5
34 MMRN2_1 0.0000020377 0.0006381430782712855 / 0.0028222416161458853 / 0.0076251167073391945 / 0.003923489922251829 / 0.033262979309241485 1.858452443514514e-05 / 1.5622701951466016e-05 / 3.730943185783191e-05 / 0.0001274335060935434 / 0.0007602117674326636 0.009654394 5
35 ZNF420_1 0.0000000763 0.00765254728362311 / 0.02761664002677436 / 0.005704138976540187 / 0.0062144909889472 / 0.02210665467937813 2.2557919455927213e-08 / 3.8434441624955556e-08 / 4.143652073206543e-08 / 8.451473540512692e-07 / 4.161971954576053e-06 0.013858894 5
36 ELOVL1_2 0.0000041883 0.005612639115469282 / 0.004888298105885152 / 0.008969805039998042 / 0.030404112516122277 / 0.03243772518292004 3.522904480656644e-10 / 4.32348036263409e-10 / 1.2293459738289953e-08 / 1.8913948776318332e-08 / 2.54997287465458e-07 0.016462516 5
37 CHGB_1 0.0000004668 0.01797077169605779 / 0.01038558151359997 / 0.03995334833105726 / 0.001300447845463061 / 0.02829515218286432 1.9938343577981134e-14 / 2.978187999752288e-14 / 0.0001540200268173068 / 6.798337935097158e-05 / 2.4772197524644612e-08 0.01958106 5
38 MLKL_1 0.0000005037 0.04557109838009256 / 0.020065293234851133 / 0.018782542562548483 / 0.0028710845896819668 / 0.0151749944268713 5.258350011749314e-16 / 3.5233765431361435e-16 / 1.4380692845318856e-14 / 1.6150676172067693e-09 / 2.4525625560555298e-05 0.020493003 5
39 FEZ2_1 0.0000017550 0.031477193589555245 / 0.024379882961236787 / 0.010048470855366752 / 0.011748468267345573 / 0.03714879584420702 6.312935617277429e-10 / 3.7842287030008046e-08 / 2.4657689745274255e-07 / 3.08973568823383e-07 / 2.749086098138227e-07 0.022960562 5
40 ADNP2_1 0.0000001922 0.0026926894174448815 / 0.004075435458657517 / 0.0019491268114425514 / 0.001327102464026624 1.2225480672529466e-06 / 3.0317781765339874e-07 / 5.119644519453932e-07 / 6.547354475139775e-07 0.002511089 4
41 CES2_1 0.0000000854 0.0011256917008427522 / 0.00029984671915346143 / 0.0069928898567800275 / 0.0037176072866771754 5.386350021831899e-08 / 4.097431696633607e-08 / 3.300361146039448e-07 / 2.3865798857407134e-08 0.003034009 4
42 DDR1_2 0.0000037846 0.005811854132542747 / 0.00015027886843801155 / 0.015373655199800797 / 0.010222251543950407 1.3359340041312337e-07 / 0.0004586184985847102 / 3.181191463640303e-05 / 2.4848821642062066e-05 0.00788951 4
43 PTGR1_1 0.0001294867 0.000974029004631184 / 0.010347970561211065 / 0.0033011167578337673 / 0.017006970232444858 3.75794293906824e-10 / 2.742804006281166e-10 / 6.771606681956264e-10 / 4.371488301831706e-09 0.007907522 4
44 LIN7A_1 0.0000001378 0.0003053911694309243 / 0.0008478272697591876 / 0.02960036890335299 / 0.00505471841056208 6.44051592787778e-15 / 1.6309672669483183e-12 / 5.867966338897064e-09 / 9.118314699470778e-11 0.008952076 4
45 SYNCRIP_1 0.0000002054 0.00032880733436267256 / 0.011951324766386422 / 0.0027159743199694653 / 0.02902955003102947 3.348316142238797e-07 / 1.9514280045818426e-06 / 2.6301830086705713e-07 / 7.532993598712855e-08 0.011006414 4
46 EREG_1 0.0000004009 0.013036283678806082 / 0.015688398206555057 / 0.010550376036332488 / 0.006349160970663491 3.9566088865499e-12 / 3.2858827273117755e-10 / 7.373790642942721e-08 / 1.7082322019514156e-10 0.011406055 4
47 C12orf57_1 0.0000023046 0.028957927563687466 / 0.010155427409165514 / 0.002911658631725467 / 0.01482122652336213 5.418786155576515e-08 / 9.894747993886977e-09 / 1.0898528564578497e-05 / 9.693695439206281e-06 0.01421156 4
48 PARP9_1 0.0000003928 0.014588245785000514 / 0.004624429303044866 / 0.027918024199514987 / 0.010739324225736034 1.0885372638586847e-06 / 2.7399829900956533e-05 / 1.1332635442176465e-05 / 0.0019394426591983717 0.014467506 4
49 SLITRK3_1 0.0000015095 0.008527348662485085 / 0.005576784085290364 / 0.03856475377208919 / 0.017395831116316804 4.879058800869575e-10 / 6.089275055540338e-08 / 8.719955641574723e-08 / 1.2488572217128136e-07 0.017516179 4
50 BIRC7_2 0.0000002867 0.007821970573183347 / 0.012845369111074686 / 0.031890899198805917 / 0.02364396066164544 1.415313199875648e-06 / 1.6775105441448168e-06 / 2.9271097438840027e-06 / 4.809721198171681e-07 0.01905055 4
51 ID4_1 0.0000000438 0.003637438547469328 / 0.0035281538483017986 / 0.03136639803264472 / 0.038599008286505046 4.0717260162829775e-06 / 6.566951490305026e-08 / 3.5276667485857833e-07 / 7.44565437001132e-08 0.01928275 4
52 NUCB2_1 0.0000017255 0.015046780105136083 / 0.0032323812044334427 / 0.04240343926485064 / 0.017505946985290035 8.68516823257589e-12 / 1.202306983296894e-07 / 1.0709464975577815e-07 / 3.127569243193228e-07 0.019547137 4
53 PDLIM1_2 0.0000001037 0.015202424481940903 / 0.012748370693134645 / 0.04063751247586265 / 0.022091540973998933 3.14173143142748e-08 / 3.6190255834565276e-06 / 3.7940179795671547e-06 / 4.77087797249951e-05 0.022669962 4
54 RNF219_3 0.0000000003 0.02634863692985202 / 0.03450099983593556 / 0.03513681089329 / 0.015137129753690677 7.261409909964612e-07 / 8.200694456053606e-07 / 4.0053825877934606e-07 / 8.023087556208056e-05 0.027780894 4
55 CTRB2_1 0.0002930973 0.020496866256864702 / 0.028972592148966015 / 0.032049126216131416 / 0.03681214620084693 1.3405501486551371e-06 / 6.226524992191516e-06 / 1.1541305382124772e-05 / 0.003046643299819599 0.029582683 4
56 RAB31_2 0.0000000104 0.006725175164160767 / 0.048022618740457663 / 0.04103625170396066 / 0.04997722883556261 8.150539694234232e-13 / 2.883168259855219e-11 / 1.4028815753928321e-09 / 3.0146813286497465e-07 0.036440319 4
57 INADL_2 0.0000000214 0.0001704720932348638 / 0.001471900435167172 / 0.002014853091681951 0.00015166172573858843 / 6.189932841020127e-05 / 0.0012577263128842932 0.001219075 3
58 DPYSL4_5 0.0000005775 0.0014690065976330497 / 0.00012135998144774518 / 0.002693760101625894 4.6411634719532725e-08 / 2.317754511202282e-05 / 4.294994611664571e-05 0.001428042 3
59 TMEM71_1 0.0000627736 0.004627658102704232 / 0.0006371740222421855 / 0.0004238045362036801 1.0813921624882114e-08 / 2.619185841833522e-07 / 1.5188016611726219e-06 0.001896212 3
60 TPD52L2_1 0.0000003037 0.000823176823593811 / 0.0007924860430472411 / 0.004187597686372937 3.758054827561048e-09 / 6.425156679903907e-10 / 1.2757355615837679e-08 0.00193442 3
61 PDIA3_2 0.0000000000 5.0723783667581744e-05 / 0.009226267029946443 / 0.0017778259882067805 4.9831579429374996e-06 / 1.3486634691146526e-07 / 1.5338596718321366e-05 0.003684939 3
62 KCNK6_1 0.0000030974 0.0014573918997663137 / 0.008577741421710208 / 0.001198103041045066 2.061544572083878e-08 / 3.896450174169792e-08 / 5.769947340059933e-08 0.003744412 3
63 CASP8AP2_2 0.0000000219 0.007099092180854751 / 0.0001545053835362215 / 0.00595076253249461 2.3414789029943654e-08 / 6.895486056880935e-08 / 3.937778269227827e-06 0.004401453 3
64 LIG1_2 0.0000029926 0.00035665903643679 / 2.5410658402422594e-05 / 0.014175997822512453 2.1508604917775794e-09 / 1.880923327455265e-08 / 1.4976701341341075e-07 0.004852689 3
65 ARVCF_1 0.0000000809 0.001267397044740127 / 0.003808062774578335 / 0.01865963988831641 3.633196454799821e-07 / 1.9057080324447833e-06 / 7.799389653993747e-07 0.0079117 3
66 PPP1R13L_1 0.0000006399 0.026512261541912406 / 8.131569425129391e-05 / 1.125309447182209e-05 2.5138651999817746e-07 / 6.409504618492529e-08 / 2.5997819819707715e-07 0.008868277 3
67 ELL2_1 0.0000000404 0.0018371780594793963 / 0.02029407943779478 / 0.005548792280102234 2.455332869218628e-08 / 3.107620037340903e-07 / 5.894237364187611e-06 0.009226683 3
68 TMEM74_1 0.0000000714 0.01038558151359997 / 0.01797077169605779 / 0.001300447845463061 1.1935648767376756e-12 / 3.737531077554552e-12 / 0.00012280075259138036 0.0098856 3
69 SH3KBP1_1 0.0000012067 0.012901388332189151 / 0.011880485771633283 / 0.005801481063585688 5.030397982975877e-06 / 9.894710679501381e-06 / 3.451000359467373e-05 0.010194452 3
70 AGXT2L2_4 0.0000000778 0.000513024270655123 / 0.030480389193308928 / 3.516928306401037e-05 1.0557144142948509e-10 / 9.649265913114177e-08 / 2.335866075829399e-06 0.010342861 3
71 FLNA_1 0.0006415808 0.02547058360769006 / 0.007922064339996648 / 0.0028656541081260025 2.1400622545568232e-11 / 9.470548049612122e-08 / 4.4822333426382254e-07 0.012086101 3
72 EVPL_1 0.0000007816 0.029829074750389078 / 0.0017371710506312126 / 0.008885340407261452 1.5237448098566468e-14 / 3.468917372397795e-07 / 8.845088917447386e-07 0.013483862 3
73 ITPRIPL1_1 0.0000009682 0.008791850806005239 / 0.005999339290583331 / 0.02786434125186579 1.870754955730307e-08 / 2.8287486016651227e-07 / 2.360872288601893e-06 0.01421851 3
74 MFSD5_3 0.0000006508 0.03071092956608319 / 0.003938218615229689 / 0.008114190972116433 1.5496424572725938e-08 / 3.2554288938109525e-07 / 1.0112718240540003e-07 0.014254446 3
75 IL31RA_1 0.0002445888 0.02204380039340295 / 0.0012839803246042464 / 0.02580532183784653 3.674619339449928e-07 / 4.43344243632212e-07 / 1.71578946301816e-07 0.016377701 3
76 PTP4A3_1 0.0000314449 0.020414472805311466 / 0.0014693336498995695 / 0.028891732420473607 4.776201023875552e-11 / 1.3766382593509082e-07 / 2.9989438068961905e-07 0.01692518 3
77 MMP14_1 0.0002190770 0.04352684110019303 / 0.004148689189670186 / 0.007178678169977374 7.605828771352425e-12 / 1.360797271795892e-07 / 5.390408897387927e-06 0.018284736 3
78 CAND2_3 0.0000026658 0.028895401482093127 / 0.0009805310391307427 / 0.027607746587453963 1.9907164721328134e-09 / 1.290177089971291e-07 / 1.422741749737834e-07 0.019161226 3
79 ZNF292_5 0.0000000002 0.015104769480539766 / 0.026666883622270408 / 0.017197326894837075 4.1769031641265797e-11 / 1.3947688771774266e-09 / 6.03866098049317e-10 0.019656327 3
80 EPSTI1_1 0.0000073158 0.021559234330291194 / 0.018300289055475042 / 0.02003497685558975 1.6504093087898275e-06 / 3.9975165582205597e-05 / 0.0030284224519400325 0.019964833 3
81 CD97_5 0.0000002610 0.0038275409770200564 / 0.019102004865160463 / 0.037465966805106755 3.7683675686710715e-11 / 9.765240850418052e-10 / 9.834582681938526e-09 0.020131838 3
82 POLE4_5 0.0000000093 0.043632422318038745 / 0.0070119701213412116 / 0.014099632537537078 8.269976083603455e-08 / 5.714696518125464e-08 / 1.8209465254324085e-07 0.021581342 3
83 ZDHHC5_2 0.0009125715 0.029337781272574574 / 0.010806162088221837 / 0.028710223635555462 2.0943141147316446e-08 / 5.3448156529365833e-08 / 1.3376144680099656e-06 0.022951389 3
84 CAV1_1 0.0000013507 0.026222968344836436 / 0.006833233979899956 / 0.03977242799449647 3.7284098504062e-09 / 1.981682163269309e-06 / 3.7034676836929953e-06 0.02427621 3
85 PRDM15_1 0.0000000097 0.005780178191260254 / 0.0347977957945877 / 0.03765009109633616 4.1060665120296455e-08 / 1.8022427394306964e-06 / 1.2329107436658844e-06 0.026076022 3
86 TXNL4A_1 0.0000015245 0.022383216654320942 / 0.019379827420147825 / 0.04981058007691468 1.0003973542061314e-07 / 8.318120908222264e-07 / 1.8197652803291898e-07 0.030524541 3
87 PITX1_1 0.0000080593 0.022158530235155818 / 0.031511227848390264 / 0.04273165395476099 4.328726238704806e-08 / 4.785592074987919e-06 / 4.026072305691093e-05 0.032133804 3
88 CDCA5_1 0.0000010967 0.00020876871631167866 / 1.4383640936438872e-05 3.9804264133636086e-05 / 7.242291833169782e-06 0.000111576 2
89 S100A8_1 0.0000173360 0.00032665136423885464 / 0.001217467053354236 6.539606399624481e-07 / 3.473013871109409e-05 0.000772059 2
90 ZNF345_2 0.0000000001 0.0027538076156700553 / 0.0004164659422400142 5.581451003007147e-05 / 2.582604692500973e-05 0.001585137 2
91 CXXC1_2 0.0000000039 0.0037862695623801213 / 0.0005840830556010548 5.223754637766254e-09 / 5.323504510648734e-08 0.002185176 2
92 ANO4_1 0.0000001136 0.004075435458657517 / 0.001327102464026624 3.235805354734205e-09 / 2.3414451573295386e-08 0.002701269 2
93 STAG2_1 0.0000009873 0.0009656381268940972 / 0.004460012570027854 1.0115034206791287e-06 / 5.753841279635619e-06 0.002712825 2
94 PBX4_1 0.0000007099 0.0037817634953029654 / 0.004617838797443333 2.7021040256543387e-08 / 9.484222614246193e-06 0.004199801 2
95 RRM1_1 0.0000018281 0.00020876871631167866 / 0.010067369603256736 2.998747278117476e-12 / 3.3209239192147915e-07 0.005138069 2
96 NUPL1_2 0.0000000000 0.00041289281227492434 / 0.011652453812603707 1.0657713091915916e-05 / 1.3751517277887033e-05 0.006032673 2
97 MCFD2_2 0.0000002619 0.011150109007006106 / 0.0014577507615148278 2.5410316626468867e-07 / 2.943498549327363e-07 0.00630393 2
98 IKBKAP_1 0.0000058887 0.012665982332335715 / 0.00011000641224999337 1.37456436935247e-06 / 3.934205458402021e-07 0.006387994 2
99 KHK_2 0.0000008186 0.00035665903643679 / 0.014175997822512453 1.4320134905312087e-10 / 9.941441418824106e-06 0.007266328 2
100 SEMA4B_1 0.0000003052 0.0015843420398457381 / 0.015326901145981139 1.468853625012769e-07 / 6.70265240601655e-08 0.008455622 2
101 CEP41_1 0.0000001044 0.002099065390574213 / 0.015250218982745749 1.5608353601998867e-06 / 2.2562783101267498e-06 0.008674642 2
102 DTX3L_1 0.0000012287 0.014588245785000514 / 0.004624429303044866 4.3810913690562183e-07 / 1.043509176420455e-05 0.009606338 2
103 SMC2_1 0.0028804091 0.013707617481622131 / 0.006160764737320071 2.8848576349790795e-08 / 3.01310962529332e-06 0.009934191 2
104 HDAC6_1 0.0009422566 0.010972403654712403 / 0.009810990348338811 1.4716710804724593e-08 / 1.7471497758357106e-07 0.010391697 2
105 KDM3A_1 0.0000075561 0.006171913156047586 / 0.014901187095494001 9.834101497765351e-06 / 2.6427885077789545e-05 0.01053655 2
106 DCAKD_1 0.0000000370 0.0018371780594793963 / 0.02029407943779478 2.2436458658220796e-06 / 3.459304592667202e-06 0.011065629 2
107 DUSP5_1 0.0000000812 0.0018371780594793963 / 0.02029407943779478 8.010663169482405e-08 / 1.019028088460542e-05 0.011065629 2
108 PRPF40A_2 0.0000001288 0.014088198537650237 / 0.008403090707899564 5.6662577214788655e-06 / 5.296682535807921e-06 0.011245645 2
109 PPIB_4 0.0000014621 0.0009023360158888423 / 0.024925919514816482 4.368833166819811e-08 / 1.5361134806777145e-05 0.012914128 2
110 ERAP2_2 0.0000000000 0.012146048132262622 / 0.016053861578409306 8.639554915354646e-08 / 3.070087173430692e-07 0.014099955 2
111 BAALC_1 0.0000002690 0.01038558151359997 / 0.01797077169605779 1.6931423038276145e-08 / 1.1971112083511357e-08 0.014178177 2
112 CACNA2D2_1 0.0000006401 0.01038558151359997 / 0.01797077169605779 3.602719217532972e-10 / 4.92697188032859e-10 0.014178177 2
113 CNPY4_1 0.0000002878 0.013815890119720394 / 0.014734308310181646 1.4477884917386144e-08 / 1.2870154644475552e-06 0.014275099 2
114 ANO5_1 0.0000004289 0.01945182673395856 / 0.010144750097293938 1.0116195313294412e-06 / 1.0659601228586417e-07 0.014798288 2
115 KLK6_2 0.0000031514 0.010648596334043373 / 0.01921308313009029 6.133714219132002e-07 / 2.6008835809083705e-06 0.01493084 2
116 TNIP2_1 0.0000070282 0.026512261541912406 / 0.0034616019934828575 1.2306882876630733e-08 / 9.976408891048964e-06 0.014986932 2
117 KCNJ11_4 0.0000008906 0.000513024270655123 / 0.030480389193308928 9.976114533861802e-12 / 1.3939033644956155e-06 0.015496707 2
118 MED14_1 0.0000001777 0.002121580446747506 / 0.02895588272033544 7.223100165739173e-08 / 5.7035521946275234e-06 0.015538732 2
119 PDGFC_3 0.0000264872 0.019513649031375167 / 0.01309714342199912 6.270077252140188e-07 / 9.870611279741555e-05 0.016305396 2
120 SLFN12_2 0.0000134765 0.02168635011054641 / 0.01167533043285143 1.966242069154016e-09 / 3.0933346339022715e-08 0.01668084 2
121 PDP1_5 0.0000352407 0.026311459966079555 / 0.007838360079130574 4.024957504543219e-05 / 1.4145520941653468e-05 0.01707491 2
122 IER5L_1 0.0000221943 0.02740923337273586 / 0.007187884748118219 4.3782241525162567e-08 / 1.83420306508174e-08 0.017298559 2
123 ABCA5_2 0.0000000000 0.026787063397349216 / 0.00879535947608833 1.3685460854987295e-06 / 8.008743570631834e-06 0.017791211 2
124 CABP7_1 0.0000019025 0.027796287019492286 / 0.008385988903950798 5.44509537364398e-08 / 4.285397797391745e-06 0.018091138 2
125 FCRLB_5 0.0000000126 0.029561026010091924 / 0.009477250370701233 8.716818657445855e-09 / 3.812867727785123e-08 0.019519138 2
126 TIGD3_1 0.0000185890 0.004581158169040506 / 0.0362634468993579 1.1724478296921851e-13 / 2.0363624639109813e-05 0.020422303 2
127 ZNF295_1 0.0000305440 0.026753893459817307 / 0.01508657655367455 2.7477807935711586e-07 / 1.7656093493156047e-07 0.020920235 2
128 PLD2_1 0.0000002785 0.027334357885610883 / 0.015006814582667545 6.430412303297122e-07 / 6.394643388050702e-07 0.021170586 2
129 CD55_1 0.0000001511 0.0033161838556922097 / 0.04158968004878196 6.746452037536084e-10 / 2.2063569025007715e-08 0.022452932 2
130 QKI_3 0.0000181952 0.005022174375240862 / 0.042671396636541896 3.032049011104229e-07 / 3.826421197615377e-07 0.023846786 2
131 MZT1_1 0.0000022280 0.0014965558133177162 / 0.046327505690930644 5.073920441583328e-06 / 6.37180443076072e-06 0.023912031 2
132 SEMA7A_1 0.0000140236 0.03342502222700243 / 0.015261311481267638 4.5276764265942424e-06 / 2.6190564781077353e-06 0.024343167 2
133 ROR2_1 0.0000162778 0.02545372903328934 / 0.02593175339775004 5.907585641697503e-08 / 1.241188472253612e-06 0.025692741 2
134 TRIP6_1 0.0000020904 0.038556379049173375 / 0.013202467191346512 2.7542851202738477e-08 / 5.023495130487458e-08 0.025879423 2
135 C14orf142_1 0.0000007942 0.005868270029793827 / 0.046553563135817905 9.376272681986819e-08 / 4.128986695162416e-06 0.026210917 2
136 ZEB1_2 0.0000468499 0.0213162921786289 / 0.0376737496455549 9.176186713429999e-08 / 2.4212534015690606e-05 0.029495021 2
137 NIP7_2 0.0000000218 0.03316581736784557 / 0.0271384576648737 4.075740819100947e-06 / 5.399297858392524e-06 0.030152138 2
138 GNAO1_1 0.0000005231 0.033760894472022615 / 0.026780216732580863 1.499270713634952e-09 / 1.217458355445439e-05 0.030270556 2
139 FGF9_1 0.0000005137 0.03951670000167351 / 0.02495147370057548 2.989061419962864e-12 / 1.737392805769214e-09 0.032234087 2
140 SERINC3_1 0.0000008268 0.026334033069056118 / 0.03845067832601619 9.100407986778662e-07 / 3.240588908989103e-07 0.032392356 2
141 RSBN1_1 0.0000010033 0.026040435274654685 / 0.03886956807554024 2.221315610307105e-11 / 9.033061104976416e-08 0.032455002 2
142 ARVCF_1 0.0000002829 0.026222968344836436 / 0.03977242799449647 7.483862897069276e-07 / 5.432934252510295e-07 0.032997698 2
143 DTL_1 0.0000076383 0.039542232891747735 / 0.02707374976179199 3.398617522656201e-09 / 9.59460633791626e-07 0.033307991 2
144 SRSF7_1 0.0000002874 0.0347977957945877 / 0.03765009109633616 6.847127318749837e-07 / 3.116230608631045e-07 0.036223943 2
145 IFIT5_2 0.0004701599 0.0364953120948139 / 0.037232340056821626 4.399782821011542e-06 / 1.7393118846309304e-05 0.036863826 2
146 NARF_1 0.0000022881 0.03953940913634625 / 0.03994379945480948 1.1301210005302875e-08 / 2.133257245226995e-06 0.039741604 2
147 CASP8_1 0.0000198034 0.0464587665387115 / 0.0401631181784738 1.601941993185719e-16 / 2.6864531857041694e-11 0.043310942 2
148 IL17RB_1 0.0000067045 0.04546047598682959 / 0.04334588252631349 3.033905276829337e-08 / 1.0262557517569413e-05 0.044403179 2
149 SLC15A2_1 0.0000014155 5.681660863421172e-05 1.5961846511181405e-05 5.68166E-05 1
150 SAR1B_1 0.0000005513 0.00013784539893700994 6.454907031718106e-06 0.000137845 1
151 TTC1_1 0.0000004017 0.00013784539893700994 2.336682885494787e-10 0.000137845 1
152 CRP_2 0.0000000078 0.00016321344400834376 5.576182275696905e-05 0.000163213 1
153 GGCX_1 0.0000076825 0.00017247402077598097 1.2879118524126266e-07 0.000172474 1
154 SOX9_1 0.0000013296 0.0001839790498817074 7.272296164227475e-06 0.000183979 1
155 DLX5_3 0.0000326962 0.0003180382059133217 4.664951986768726e-07 0.000318038 1
156 SNRNP25_3 0.0000000234 0.0003180382059133217 3.3152672324048814e-05 0.000318038 1
157 UHRF1BP1L_1 0.0000001071 0.000349384308330678 2.1709474268278766e-06 0.000349384 1
158 PAPD4_1 0.0000249556 0.0004361114375544852 1.8113390561602514e-06 0.000436111 1
159 ADAMTS14_1 0.0000437150 0.0005765804746846872 6.590376972707598e-05 0.00057658 1
160 FAT2_1 0.0000012964 0.0006381430782712855 4.603295730722451e-06 0.000638143 1
161 ZNF750_2 0.0000000299 0.0007846622552824629 4.022726992390641e-05 0.000784662 1
162 BTG2_1 0.0000093251 0.0008391695317782487 3.5774320349838873e-07 0.00083917 1
163 PIGB_4 0.0000000787 0.0009023360158888423 2.2878500220993498e-11 0.000902336 1
164 WHAMM_4 0.0000010450 0.0009023360158888423 1.1651758424474298e-06 0.000902336 1
165 PELI2_2 0.0000000141 0.0012894304816227693 8.58480971255917e-08 0.00128943 1
166 RPS5_1 0.0000036423 0.00134963344272631 2.405506994776735e-06 0.001349633 1
167 DALRD3_1 0.0000008658 0.0013670815874214685 1.1128380015615429e-08 0.001367082 1
168 ANKRD22_1 0.0000009306 0.0014573918997663137 3.138691465570034e-07 0.001457392 1
169 AGBL4_5 0.0000001940 0.0014690065976330497 3.7344924411524894e-05 0.001469007 1
170 DCUN1D2_1 0.0000001810 0.0014965558133177162 2.6955640062447783e-06 0.001496556 1
171 RAP2A_1 0.0000043749 0.0014965558133177162 3.643928917883914e-07 0.001496556 1
172 TEX30_1 0.0000077886 0.0014965558133177162 7.322882011832241e-07 0.001496556 1
173 CPNE8_1 0.0000012221 0.0015823634728436365 1.0569424770637742e-11 0.001582363 1
174 IFIT3_1 0.0000007653 0.0015904564617824036 2.30780238404599e-06 0.001590456 1
175 KCNMB2_1 0.0000003403 0.0015904564617824036 1.6585833620905925e-08 0.001590456 1
176 TRIM21_1 0.0000000854 0.0015904564617824036 2.1285881318643393e-08 0.001590456 1
177 NAP1L4_1 0.0000087541 0.0017153185879343034 7.850131843413566e-06 0.001715319 1
178 GALNT3_1 0.0000354752 0.0020476470911988563 2.5573822901107337e-05 0.002047647 1
179 EVL_1 0.0000019885 0.002058130936511972 2.717135803874761e-09 0.002058131 1
180 TSPAN8_1 0.0000003090 0.0021489267613823003 1.017187347139058e-05 0.002148927 1
181 RUNDC3B_1 0.0000041888 0.0024846662085153902 1.016379726019311e-05 0.002484666 1
182 CCDC113_1 0.0000076744 0.0025150135152389474 1.5032272736368673e-06 0.002515014 1
183 PIAS2_2 0.0000001786 0.0025152679462084955 2.2483779303553648e-06 0.002515268 1
184 ALG14_1 0.0000072016 0.0026041641330007506 0.0006233183228222267 0.002604164 1
185 TAF11_1 0.0000009139 0.002687295907204792 0.00012476609977995568 0.002687296 1
186 KCNK9_1 0.0011919577 0.0028046841261304568 1.376632392689302e-07 0.002804684 1
187 LRRC8A_1 0.0000035240 0.0032327742303384166 6.356756636137029e-06 0.003232774 1
188 TMEM151B_1 0.0000007358 0.0032636781607269594 1.8328686422960692e-06 0.003263678 1
189 C10orf76_1 0.0000881113 0.003434642569271992 7.673926087001424e-06 0.003434643 1
190 NXNL2_1 0.0000597168 0.003544372498506248 3.942459986260573e-08 0.003544372 1
191 TCEB3_1 0.0005226535 0.0037150885246972363 0.00024989766039529933 0.003715089 1
192 CPEB2_2 0.0000010060 0.003774743841069769 2.850551586644877e-06 0.003774744 1
193 TUBB_1 0.0000000607 0.0037817634953029654 8.334855345042203e-07 0.003781763 1
194 UBE2H_1 0.0000005261 0.004043548766154216 2.7343581965712453e-07 0.004043549 1
195 TM9SF4_1 0.0000000634 0.004075435458657517 1.208568331650002e-06 0.004075435 1
196 ZNF250_1 0.0001614132 0.004581158169040506 8.906742496574832e-08 0.004581158 1
197 ARSD_1 0.0000007813 0.004617838797443333 4.0431258909202725e-06 0.004617839 1
198 ZBED5_5 0.0000000106 0.005222164163583828 1.6160725995889468e-06 0.005222164 1
199 TEAD3_3 0.0000036458 0.0053872635110084445 4.1927795302166964e-05 0.005387264 1
200 PAICS_1 0.0023017121 0.005473511421368178 0.001803574650219185 0.005473511 1
201 SDSL_1 0.0000016496 0.006403254151390212 7.017651789933182e-08 0.006403254 1
202 SP140L_1 0.0000004574 0.00690906973800756 1.4293392545039821e-08 0.00690907 1
203 VEZF1_1 0.0000006200 0.007512524281614588 4.015799360215652e-07 0.007512524 1
204 TSR2_2 0.0000001115 0.00807009151771129 5.455073735317627e-08 0.008070092 1
205 LRFN5_1 0.0001487507 0.00837748774812484 1.765094200227484e-07 0.008377488 1
206 HMOX1_3 0.0000000049 0.009019901589667713 3.3116226812292643e-07 0.009019902 1
207 OAF_2 0.0000021448 0.010087189185487436 6.611044842333954e-06 0.010087189 1
208 C1orf198_1 0.0047644878 0.01058743988900243 5.33047484084318e-06 0.01058744 1
209 RNF145_1 0.0000015182 0.010685297092225236 3.4948918270211384e-09 0.010685297 1
210 TFDP1_2 0.0000000087 0.011664876607743443 1.0484496266632918e-06 0.011664877 1
211 TRIM33_5 0.0000006448 0.012312852331877405 5.823849535285043e-07 0.012312852 1
212 BRD1_1 0.0000056060 0.012444591121133452 9.00450493226787e-08 0.012444591 1
213 RAB18_1 0.0000000557 0.012469136109983507 7.808669892591835e-06 0.012469136 1
214 DOK6_1 0.0000225131 0.0126479390211753 2.9116700927572027e-07 0.012647939 1
215 TMEM132D_1 0.0000007064 0.014125552794811447 0.00013933215110235875 0.014125553 1
216 RBKS_1 0.0000039408 0.014510361909036783 1.369930658748886e-10 0.014510362 1
217 SDPR_1 0.0000144016 0.015098577756027905 1.2200927403044487e-06 0.015098578 1
218 HADHB_3 0.0000011607 0.015198702702676786 4.67481146425626e-06 0.015198703 1
219 RAB2B_1 0.0000015355 0.015525342789786052 9.240171811293034e-08 0.015525343 1
220 CLSPN_2 0.0015604856 0.015681284994245294 4.787605013931291e-06 0.015681285 1
221 LRCH2_1 0.0000013499 0.016913586137948928 3.239478361523596e-06 0.016913586 1
222 RIC8B_1 0.0000258855 0.018613210669019453 2.5972193291243487e-07 0.018613211 1
223 SNX17_1 0.0000005150 0.0187791714585435 7.832292477544212e-06 0.018779171 1
224 HPS1_3 0.0000193423 0.020032646836294014 2.651724363437782e-08 0.020032647 1
225 TNNT3_1 0.0000037981 0.02003497685558975 0.0024373027878036467 0.020034977 1
226 MPHOSPH9_1 0.0000010033 0.020273128817757814 5.7180542135867475e-06 0.020273129 1
227 PCDH7_1 0.0000026780 0.020321552294661337 1.8717328001192637e-06 0.020321552 1
228 NSL1_1 0.0000025413 0.020596934169840004 1.6439984899784691e-06 0.020596934 1
229 ALG9_1 0.0001111425 0.022935884489828733 1.7377644622722088e-06 0.022935884 1
230 PDE12_1 0.0000004658 0.0233155726865293 1.5807742224423866e-05 0.023315573 1
231 PAPSS2_1 0.0000007706 0.024338654294994898 9.283888609188878e-08 0.024338654 1
232 ZFHX2_1 0.0000004187 0.02464096203134193 2.8806779697573074e-06 0.024640962 1
233 TFG_2 0.0000000179 0.02485916255363959 5.4417829495431724e-05 0.024859163 1
234 IL15RA_1 0.0000004083 0.02498090614719385 2.4652810837821435e-06 0.024980906 1
235 MBTD1_1 0.0000000005 0.02498090614719385 2.476481267971609e-05 0.024980906 1
236 TMPRSS4_1 0.0001737302 0.02527275878591322 4.96032498878352e-07 0.025272759 1
237 APBB1_1 0.0007952642 0.025477899370092264 1.1177566606698288e-07 0.025477899 1
238 MAD2L2_1 0.0000650171 0.025477899370092264 7.015450869623152e-07 0.025477899 1
239 MAP4_1 0.0000021567 0.026512261541912406 5.151370139997939e-07 0.026512262 1
240 GLTP_1 0.0000002645 0.02685009566751369 1.2940153369292968e-05 0.026850096 1
241 CECR2_1 0.0000034126 0.02695039496870006 4.8390480434201144e-06 0.026950395 1
242 RUFY1_1 0.0000299227 0.027256120811697704 8.232591388149916e-11 0.027256121 1
243 LRRN1_3 0.0000000006 0.027852483618169322 2.4617114447232193e-06 0.027852484 1
244 ATRIP_1 0.0000459410 0.028297897669394324 3.581872487568641e-06 0.028297898 1
245 NADKD1_1 0.0001614851 0.030463092594199083 9.476649004029163e-08 0.030463093 1
246 DAPL1_5 0.0000001131 0.03247309026025267 1.063046591606967e-06 0.03247309 1
247 HSD17B10_1 0.0000356915 0.03300637436842342 3.315891641410488e-08 0.033006374 1
248 CTSL1_5 0.0000012024 0.033080135108199266 2.1760418610560375e-10 0.033080135 1
249 PPM1F_2 0.0000003736 0.033564554983805193 6.023420324819565e-06 0.033564555 1
250 SERPINB8_1 0.0000004020 0.03395639101055327 7.590142415124812e-06 0.033956391 1
251 LEPREL4_1 0.0000031108 0.03517044127467462 9.048855093781964e-06 0.035170441 1
252 HIRA_1 0.0000071773 0.036656389092885745 6.41338762201109e-06 0.036656389 1
253 MET_2 0.0000048647 0.03675726542857143 4.0499324464518144e-07 0.036757265 1
254 ST18_2 0.0000003070 0.03675726542857143 2.1367286772341655e-08 0.036757265 1
255 IFI35_1 0.0000001142 0.037485659344956734 1.8673858169252516e-08 0.037485659 1
256 CNKSR3_1 0.0000002224 0.0380562899913768 1.4065162180136549e-05 0.03805629 1
257 NFKBIZ_1 0.0002437797 0.038514781543232596 2.106101897324396e-07 0.038514782 1
258 TFPI_1 0.0050804078 0.038514781543232596 7.186644444797165e-08 0.038514782 1
259 PDIA6_1 0.0000012653 0.038781900239634945 1.1794828467593882e-06 0.0387819 1
260 RSF1_3 0.0000000002 0.03932106882555421 1.1649216389446077e-06 0.039321069 1
261 MYO1E_2 0.0000209873 0.039881619914679374 4.562099888852519e-11 0.03988162 1
262 UBAP1_1 0.0000010913 0.040258840897526606 2.649945837106964e-07 0.040258841 1
263 GFER_1 0.0000199213 0.041058990270996985 1.013140578199153e-06 0.04105899 1
264 C17orf75_1 0.0000001475 0.041863358380761856 2.011957469008045e-05 0.041863358 1
265 TTC9B_1 0.0000199304 0.0440605439544666 1.3515245965925785e-06 0.044060544 1
266 FAM198B_1 0.0000000398 0.04544630802892216 1.2975083762851168e-06 0.045446308 1
267 DCTD_1 0.0000002300 0.045495607074215974 9.613702843960257e-08 0.045495607 1
268 ZSCAN16_1 0.0000002003 0.04907931555044797 6.364155025566868e-08 0.049079316 1
269 CCDC14_2 0.0000000040 0.049412789880137475 1.0956612304568067e-06 0.04941279 1
270 TRIP11_1 0.0000106522 0.049477459520320635 3.616757502303368e-08 0.04947746 1
271 NKAIN2_1 0.0000341788 0.04968678580260802 1.3235403934017564e-06 0.049686786 1
272 NT5E_1 0.0000065065 0.04968678580260802 1.050035169104463e-10 0.049686786 1
273 PPP1R14A_5 0.0000105571 0.00022092891960888485 5.27242603779648e-05 0.000220929 1
274 CDH2_1 0.0001087650 0.0005511270416472728 0.0004028031199308745 0.000551127 1
275 EMC3_1 0.0000000114 0.0006784104611363802 3.0652280007137936e-05 0.00067841 1
276 NCAPG2_1 0.0000228504 0.0007900043500214932 0.0004768223953633258 0.000790004 1
277 OR13H1_2 0.0011906247 0.024195410263062368 0.024770686509726116 0.02419541 1
[표 12]에는 육종암(bone) 약물에 연관된 FRH 들과, 이와 연관된 육종암 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 13] 에는 [표 12]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(Pvlaue)값을 의미하는 것으로, [표 12]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 12]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 육종암 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 35에는 표 12에 기재된 바이오마커들 중 주요 바이오마커들의 육종암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 36에는 주요 바이오마커들에 의해 발현된 유전자들과 육종암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
육종암(bone) 약물에 대한 반응성 바이오 마커
No. FRH Drug DrugType Var(마커)
1 LUC7L_5 263_FR-180204 / 310_YM201636 / 294_MPS-1-IN-1 / 228_KIN001-102 / 326_GSK690693 / 288_KIN001-055 / 303_PIK-93 / 1498_AZD6244 / 305_TPCA-1 / 271_VNLG/124 / 245_UNC0638 / 330_XMD13-2 / 282_EKB-569 / 1526_RDEA119 (rescreen) / 286_KIN001-236 / 344_THZ-2-49 / 256_JW-7-24-1 / 185_OSI-906 / 304_SB52334 / 265_Tubastatin A / 283_GSK2126458 / 253_XMD14-99 / 346_THZ-2-102-1 / 298_OSI-930 / 257_NPK76-II-72-1 / 1372_Trametinib / 331_QL-X-138 / 1014_RDEA119 / 290_KIN001-260 / 221_TAK-715 / 252_WZ3105 / 276_CAY10603 / 287_KIN001-244 / 306_TG101348 / 179_5-Fluorouracil / 301_PHA-793887 / 273_CUDC-101 / 291_KIN001-266 / 300_CX-5461 / 226_GSK1070916 / 1010_Gefitinib / 281_CH5424802 / 1242_(5Z)-7-Oxozeaenol / 223_ZSTK474 / 1011_ABT-263 / 292_Masitinib / 1008_Methotrexate / 175_PAC-1 / 299_OSI-027 / 238_CAL-101 / 275_I-BET-762 / 225_Genentech Cpd 10 / 328_SNX-2112 / 254_AC220 / 211_TL-2-105 / 274_Belinostat / 260_NG-25 / 279_BIX02189 / 152_CP466722 / 272_AR-42 / 136_Mitomycin C / 222_BX-912 / 208_SB-715992 / 184_BMS-754807 / 56_WH-4-023 / 1218_JQ1 / 1091_BMS-536924 / 1017_Olaparib / 341_EX-527 / 261_TL-1-85 / 1259_BMN-673 / 1060_PD-0325901 / 205_BMS-708163 / 196_Phenformin / 302_PI-103 / 309_Y-39983 / 1020_Lenalidomide / 1005_Cisplatin / 1262_UNC1215 / 329_QL-XI-92 / 1495_Olaparib / 295_NVP-BHG712 / 258_STF-62247 / 200_LAQ824 / 1026_17-AAG / 1039_SL 0101-1 / 255_CP724714 / 219_AT-7519 / 308_XL-880 / 1248_FK866 / 224_AS605240 / 235_QL-XII-47 / 203_BMS-345541 / 182_Obatoclax Mesylate / 1012_Vorinostat / 1013_Nilotinib / 1175_AG-014699 / 135_Gemcitabine / 266_Zibotentan / 178_BAY 61-3606 / 332_XMD15-27 / 1264_SGC0946 / 1166_QL-VIII-58 / 1018_ABT-888 / 1069_EHT 1864 erk_mapk / other / mitosis / pi3k / pi3k / other / pi3k / erk_mapk / other / chromatin / chromatin / other / egfr / erk_mapk / other / cell_cyc / other / igfr / rtk / chromatin / pi3k / rtk / cell_cyc / rtk / mitosis / erk_mapk / other / erk_mapk / other / jnk_p38 / other / chromatin / pi3k / other / DNArep / cell_cyc / chromatin / other / other / mitosis / egfr / rtk / other / pi3k / apop / rtk / DNArep / apop / tor / pi3k / chromatin / mitosis / other / rtk / erk_mapk / chromatin / other / other / g_integrity / chromatin / DNArep / pi3k / mitosis / igfr / abl / chromatin / igfr / g_integrity / other / other / g_integrity / erk_mapk / other / metabol / pi3k / cytoskeleton / other / DNArep / other / rtk / g_integrity / rtk / other / chromatin / other / erk_mapk / egfr / cell_cyc / rtk / metabol / pi3k / other / other / apop / chromatin / abl / g_integrity / DNArep / other / other / other / chromatin / tor / g_integrity / cytoskeleton 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 5_141432375_A_C / 22_18847351_G_C
2 FZD3_1 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 223_ZSTK474_2 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 304_SB52334_3 / 224_AS605240_3 / 282_Pelitinib_2 / 253_XMD14-99_3 / 263_FR-180204_3 / 326_GSK690693_3 / 152_CP466722_3 / 225_Genentech Cpd 10_3 / 290_KIN001-260_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 286_KIN001-236_3 / 238_Idelalisib_1 / 299_OSI-027_2 / 272_AR-42_2 / 298_OSI-930_2 / 222_BX-912_3 / 265_Tubastatin A_3 / 275_I-BET-762_3 / 306_Fedratinib_2 / 276_CAY10603_3 / 208_Ispinesib Mesylate_2 / 203_BMS-345541_3 / 256_JW-7-24-1_3 / 274_Belinostat_1 / 301_PHA-793887_3 / 219_AT-7519_2 / 303_PIK-93_3 / 252_WZ3105_3 / 329_QL-XI-92_3 / 257_NPK76-II-72-1_3 / 273_CUDC-101_2 / 1091_BMS-536924_3 / 288_WHI-P97_3 / 261_TL-1-85_3 / 211_TL-2-105_3 / 271_VNLG/124_3 pi3k / mitosis / pi3k / pi3k / other / mitosis / other / rtk / rtk / pi3k / egfr / rtk / erk_mapk / pi3k / g_integrity / mitosis / other / other / jnk_p38 / other / pi3k / tor / chromatin / rtk / pi3k / chromatin / chromatin / other / chromatin / mitosis / other / other / chromatin / cell_cyc / cell_cyc / pi3k / other / rtk / mitosis / chromatin / igfr / other / other / erk_mapk / chromatin 1_26457907_T_G
3 LMBR1L_3 261_TL-1-85_3 / 281_Alectinib_2 / 291_KIN001-266_3 / 346_THZ-2-102-1_3 / 310_YM201636_3 / 257_NPK76-II-72-1_3 / 344_THZ-2-49_3 / 303_PIK-93_3 / 286_KIN001-236_3 / 256_JW-7-24-1_3 / 328_SNX-2112_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 287_KIN001-244_3 / 294_MPS-1-IN-1_3 / 260_NG-25_3 / 290_KIN001-260_3 / 345_KIN001-270_3 / 208_Ispinesib Mesylate_2 / 301_PHA-793887_3 / 305_TPCA-1_3 / 331_QL-X-138_3 / 225_Genentech Cpd 10_3 / 299_OSI-027_2 / 273_CUDC-101_2 / 276_CAY10603_3 / 226_GSK1070916_2 / 265_Tubastatin A_3 / 292_Masitinib_1 / 263_FR-180204_3 / 272_AR-42_2 / 152_CP466722_3 / 326_GSK690693_3 / 283_Omipalisib_2 other / rtk / other / cell_cyc / other / mitosis / cell_cyc / pi3k / other / other / other / other / other / pi3k / mitosis / other / other / cell_cyc / mitosis / cell_cyc / other / other / mitosis / tor / chromatin / chromatin / mitosis / chromatin / rtk / erk_mapk / chromatin / g_integrity / pi3k / pi3k 20_35697711_A_C / 7_72949311_A_C / 12_109266204_T_G
4 ACTN2_3 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 328_SNX-2112_3 / 344_THZ-2-49_3 / 290_KIN001-260_3 / 287_KIN001-244_3 / 304_SB52334_3 / 330_XMD13-2_3 / 256_JW-7-24-1_3 / 245_UNC0638_3 / 252_WZ3105_3 / 299_OSI-027_2 / 257_NPK76-II-72-1_3 / 286_KIN001-236_3 / 152_CP466722_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 346_THZ-2-102-1_3 / 179_5-Fluorouracil_1 / 260_NG-25_3 / 253_XMD14-99_3 / 226_GSK1070916_2 / 331_QL-X-138_3 / 261_TL-1-85_3 / 279_BIX02189_3 / 223_ZSTK474_2 / 291_KIN001-266_3 / 271_VNLG/124_3 other / erk_mapk / mitosis / other / pi3k / pi3k / other / other / cell_cyc / other / pi3k / rtk / other / other / chromatin / other / tor / mitosis / other / g_integrity / pi3k / pi3k / cell_cyc / DNArep / other / rtk / mitosis / other / other / other / pi3k / other / chromatin 1_26457907_T_G / 22_18847351_G_C / 22_21127217_C_G
5 UBXN7_2 310_YM201636_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 / 256_JW-7-24-1_3 / 265_Tubastatin A_3 / 226_GSK1070916_2 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 271_VNLG/124_3 / 301_PHA-793887_3 / 185_Linsitinib_2 / 1017_Olaparib_2 / 253_XMD14-99_3 / 136_Mitomycin-C_1 / 1495_Olaparib_1 / 281_Alectinib_2 / 257_NPK76-II-72-1_3 / 292_Masitinib_1 / 1003_Camptothecin_1 / 290_KIN001-260_3 / 298_OSI-930_2 / 283_Omipalisib_2 / 300_CX-5461_3 / 304_SB52334_3 / 273_CUDC-101_2 / 223_ZSTK474_2 / 299_OSI-027_2 / 331_QL-X-138_3 other / g_integrity / cell_cyc / other / other / mitosis / pi3k / erk_mapk / other / chromatin / mitosis / other / pi3k / chromatin / cell_cyc / igfr / g_integrity / rtk / DNArep / g_integrity / rtk / mitosis / rtk / DNArep / other / rtk / pi3k / other / rtk / chromatin / pi3k / tor / other 22_24252424_G_C / 1_26457907_T_G
6 TRAM2_2 226_GSK1070916_2 / 310_YM201636_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 305_TPCA-1_3 / 299_OSI-027_2 / 228_AKT_inhibitor_VIII_3 / 256_JW-7-24-1_3 / 221_TAK-715_2 / 252_WZ3105_3 / 346_THZ-2-102-1_3 / 301_PHA-793887_3 / 222_BX-912_3 / 1259_Talazoparib_3 / 257_NPK76-II-72-1_3 / 283_Omipalisib_2 / 208_Ispinesib Mesylate_2 / 253_XMD14-99_3 / 303_PIK-93_3 / 326_GSK690693_3 / 344_THZ-2-49_3 / 304_SB52334_3 / 302_PI-103_3 / 286_KIN001-236_3 / 287_KIN001-244_3 / 223_ZSTK474_2 / 225_Genentech Cpd 10_3 / 254_Quizartinib_2 / 265_Tubastatin A_3 / 331_QL-X-138_3 mitosis / other / erk_mapk / other / mitosis / other / other / tor / pi3k / other / jnk_p38 / other / cell_cyc / cell_cyc / pi3k / g_integrity / mitosis / pi3k / mitosis / rtk / pi3k / pi3k / cell_cyc / rtk / pi3k / other / pi3k / pi3k / mitosis / rtk / chromatin / other 1_26457907_T_G / 22_21127217_C_G
7 CDK13_2 326_GSK690693_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 301_PHA-793887_3 / 331_QL-X-138_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 306_Fedratinib_2 / 275_I-BET-762_3 / 295_NVP-BHG712_3 / 279_BIX02189_3 / 256_JW-7-24-1_3 / 346_THZ-2-102-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 226_GSK1070916_2 / 286_KIN001-236_3 / 290_KIN001-260_3 / 257_NPK76-II-72-1_3 / 299_OSI-027_2 / 282_Pelitinib_2 / 223_ZSTK474_2 / 245_UNC0638_3 / 304_SB52334_3 / 302_PI-103_3 / 253_XMD14-99_3 / 328_SNX-2112_3 / 238_Idelalisib_1 pi3k / other / cell_cyc / other / pi3k / erk_mapk / cell_cyc / other / pi3k / mitosis / other / other / chromatin / rtk / other / other / cell_cyc / other / pi3k / mitosis / other / other / mitosis / tor / egfr / pi3k / chromatin / rtk / pi3k / rtk / other / pi3k 1_26457907_T_G / 22_30937565_T_G
8 BCL11B_3 310_YM201636_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 263_FR-180204_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 256_JW-7-24-1_3 / 226_GSK1070916_2 / 288_WHI-P97_3 / 257_NPK76-II-72-1_3 / 303_PIK-93_3 / 290_KIN001-260_3 / 299_OSI-027_2 / 276_CAY10603_3 / 245_UNC0638_3 / 326_GSK690693_3 / 152_CP466722_3 / 283_Omipalisib_2 / 273_CUDC-101_2 / 346_THZ-2-102-1_3 / 223_ZSTK474_2 / 274_Belinostat_1 / 304_SB52334_3 / 279_BIX02189_3 / 1259_Talazoparib_3 / 272_AR-42_2 / 286_KIN001-236_3 / 287_KIN001-244_3 other / cell_cyc / other / erk_mapk / other / pi3k / other / mitosis / rtk / other / mitosis / other / mitosis / pi3k / other / tor / chromatin / chromatin / pi3k / g_integrity / pi3k / chromatin / cell_cyc / pi3k / chromatin / rtk / other / g_integrity / chromatin / other / pi3k 1_26457907_T_G / 5_141432375_A_C / 22_22643666_C_G
9 LONRF1_4 344_THZ-2-49_3 / 288_WHI-P97_3 / 263_FR-180204_3 / 310_YM201636_3 / 330_XMD13-2_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 252_WZ3105_3 / 256_JW-7-24-1_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 299_OSI-027_2 / 303_PIK-93_3 / 291_KIN001-266_3 / 279_BIX02189_3 / 346_THZ-2-102-1_3 / 276_CAY10603_3 / 226_GSK1070916_2 / 292_Masitinib_1 / 265_Tubastatin A_3 / 273_CUDC-101_2 / 245_UNC0638_3 / 287_KIN001-244_3 / 152_CP466722_3 / 261_TL-1-85_3 / 208_Ispinesib Mesylate_2 / 1259_Talazoparib_3 cell_cyc / other / erk_mapk / other / other / mitosis / mitosis / other / other / other / other / other / pi3k / tor / pi3k / other / other / cell_cyc / chromatin / mitosis / rtk / chromatin / chromatin / chromatin / pi3k / g_integrity / other / mitosis / g_integrity 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 15_42142087_A_C
10 NUDT16_1 344_THZ-2-49_3 / 330_XMD13-2_3 / 310_YM201636_3 / 273_CUDC-101_2 / 226_GSK1070916_2 / 272_AR-42_2 / 276_CAY10603_3 / 263_FR-180204_3 / 326_GSK690693_3 / 274_Belinostat_1 / 252_WZ3105_3 / 253_XMD14-99_3 / 265_Tubastatin A_3 / 256_JW-7-24-1_3 / 208_Ispinesib Mesylate_2 / 283_Omipalisib_2 / 228_AKT_inhibitor_VIII_3 / 301_PHA-793887_3 / 225_Genentech Cpd 10_3 / 281_Alectinib_2 / 294_MPS-1-IN-1_3 / 299_OSI-027_2 / 1259_Talazoparib_3 / 292_Masitinib_1 / 305_TPCA-1_3 / 298_OSI-930_2 / 290_KIN001-260_3 / 286_KIN001-236_3 / 257_NPK76-II-72-1_3 cell_cyc / other / other / chromatin / mitosis / chromatin / chromatin / erk_mapk / pi3k / chromatin / other / rtk / chromatin / other / mitosis / pi3k / pi3k / cell_cyc / mitosis / rtk / mitosis / tor / g_integrity / rtk / other / rtk / other / other / mitosis 1_26457907_T_G
11 BDKRB1_1 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 290_KIN001-260_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 136_Mitomycin-C_1 / 305_TPCA-1_3 / 300_CX-5461_3 / 283_Omipalisib_2 / 254_Quizartinib_2 / 221_TAK-715_2 / 226_GSK1070916_2 / 252_WZ3105_3 / 303_PIK-93_3 / 301_PHA-793887_3 / 346_THZ-2-102-1_3 / 1008_Methotrexate_1 / 304_SB52334_3 / 253_XMD14-99_3 / 257_NPK76-II-72-1_3 / 1142_HG-5-113-01_2 / 326_GSK690693_3 / 281_Alectinib_2 / 299_OSI-027_2 / 286_KIN001-236_3 other / mitosis / erk_mapk / other / pi3k / g_integrity / cell_cyc / other / DNArep / other / other / pi3k / rtk / jnk_p38 / mitosis / other / pi3k / cell_cyc / cell_cyc / DNArep / rtk / rtk / mitosis / abl / pi3k / rtk / tor / other 22_22643666_C_G
12 ACVR1B_1 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 310_YM201636_3 / 290_KIN001-260_3 / 303_PIK-93_3 / 265_Tubastatin A_3 / 276_CAY10603_3 / 225_Genentech Cpd 10_3 / 272_AR-42_2 / 228_AKT_inhibitor_VIII_3 / 274_Belinostat_1 / 253_XMD14-99_3 / 226_GSK1070916_2 / 283_Omipalisib_2 / 185_Linsitinib_2 / 257_NPK76-II-72-1_3 / 223_ZSTK474_2 / 299_OSI-027_2 / 256_JW-7-24-1_3 / 281_Alectinib_2 / 273_CUDC-101_2 / 326_GSK690693_3 / 330_XMD13-2_3 / 291_KIN001-266_3 / 152_CP466722_3 / 263_FR-180204_3 mitosis / other / rtk / other / other / pi3k / chromatin / chromatin / mitosis / chromatin / pi3k / chromatin / rtk / mitosis / pi3k / igfr / mitosis / pi3k / tor / other / rtk / chromatin / pi3k / other / other / g_integrity / erk_mapk 1_26457907_T_G
13 FUCA2_5 310_YM201636_3 / 344_THZ-2-49_3 / 245_UNC0638_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 273_CUDC-101_2 / 288_WHI-P97_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 265_Tubastatin A_3 / 256_JW-7-24-1_3 / 253_XMD14-99_3 / 304_SB52334_3 / 326_GSK690693_3 / 276_CAY10603_3 / 226_GSK1070916_2 / 271_VNLG/124_3 / 346_THZ-2-102-1_3 / 257_NPK76-II-72-1_3 / 281_Alectinib_2 / 272_AR-42_2 / 274_Belinostat_1 / 306_Fedratinib_2 other / cell_cyc / chromatin / erk_mapk / mitosis / pi3k / chromatin / other / other / other / other / pi3k / chromatin / other / rtk / rtk / pi3k / chromatin / mitosis / chromatin / cell_cyc / mitosis / rtk / chromatin / chromatin / other 1_26457907_T_G / 5_141432375_A_C / 22_18847351_G_C / 1_219210601_T_G / 22_22643666_C_G
14 ZNF862_2 226_GSK1070916_2 / 346_THZ-2-102-1_3 / 310_YM201636_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 225_Genentech Cpd 10_3 / 222_BX-912_3 / 294_MPS-1-IN-1_3 / 301_PHA-793887_3 / 265_Tubastatin A_3 / 260_NG-25_3 / 290_KIN001-260_3 / 283_Omipalisib_2 / 331_QL-X-138_3 / 328_SNX-2112_3 / 299_OSI-027_2 / 287_KIN001-244_3 / 330_XMD13-2_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 256_JW-7-24-1_3 / 302_PI-103_3 / 211_TL-2-105_3 / 208_Ispinesib Mesylate_2 mitosis / cell_cyc / other / other / mitosis / other / pi3k / mitosis / pi3k / mitosis / cell_cyc / chromatin / other / other / pi3k / other / other / tor / pi3k / other / pi3k / pi3k / other / pi3k / erk_mapk / mitosis 1_26457907_T_G / 22_22759034_G_A
15 JAKMIP2_1 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 298_OSI-930_2 / 252_WZ3105_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 326_GSK690693_3 / 306_Fedratinib_2 / 253_XMD14-99_3 / 221_TAK-715_2 / 305_TPCA-1_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 301_PHA-793887_3 / 283_Omipalisib_2 / 211_TL-2-105_3 / 208_Ispinesib Mesylate_2 / 290_KIN001-260_3 / 292_Masitinib_1 / 185_Linsitinib_2 other / pi3k / other / erk_mapk / mitosis / cell_cyc / other / rtk / other / g_integrity / mitosis / pi3k / other / rtk / jnk_p38 / other / other / rtk / cell_cyc / pi3k / erk_mapk / mitosis / other / rtk / igfr 22_21127217_C_G
16 RHBDD2_2 326_GSK690693_3 / 283_Omipalisib_2 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 304_SB52334_3 / 185_Linsitinib_2 / 310_YM201636_3 / 223_ZSTK474_2 / 299_OSI-027_2 / 256_JW-7-24-1_3 / 331_QL-X-138_3 / 346_THZ-2-102-1_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 226_GSK1070916_2 / 302_PI-103_3 / 344_THZ-2-49_3 / 219_AT-7519_2 / 245_UNC0638_3 / 330_XMD13-2_3 / 225_Genentech Cpd 10_3 / 279_BIX02189_3 pi3k / pi3k / other / mitosis / pi3k / rtk / igfr / other / pi3k / tor / other / other / cell_cyc / other / mitosis / mitosis / pi3k / cell_cyc / cell_cyc / chromatin / other / mitosis / other 1_26457907_T_G / 22_30937565_T_G
17 NELL2_2 281_Alectinib_2 / 310_YM201636_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 276_CAY10603_3 / 273_CUDC-101_2 / 257_NPK76-II-72-1_3 / 274_Belinostat_1 / 252_WZ3105_3 / 265_Tubastatin A_3 / 263_FR-180204_3 / 346_THZ-2-102-1_3 / 303_PIK-93_3 / 290_KIN001-260_3 / 305_TPCA-1_3 / 272_AR-42_2 / 222_BX-912_3 / 256_JW-7-24-1_3 / 298_OSI-930_2 / 223_ZSTK474_2 rtk / other / cell_cyc / mitosis / mitosis / other / pi3k / chromatin / chromatin / mitosis / chromatin / other / chromatin / erk_mapk / cell_cyc / pi3k / other / other / chromatin / pi3k / other / rtk / pi3k 1_26457907_T_G / 5_141432375_A_C
18 LIPI_3_23 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 298_OSI-930_2 / 256_JW-7-24-1_3 / 305_TPCA-1_3 / 286_KIN001-236_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 326_GSK690693_3 / 341_Selisistat_3 / 1259_Talazoparib_3 / 271_VNLG/124_3 / 292_Masitinib_1 / 303_PIK-93_3 / 221_TAK-715_2 / 301_PHA-793887_3 / 304_SB52334_3 erk_mapk / other / cell_cyc / mitosis / other / rtk / pi3k / other / rtk / other / other / other / other / other / pi3k / other / g_integrity / chromatin / rtk / pi3k / jnk_p38 / cell_cyc / rtk 1_26457907_T_G / 5_141432375_A_C / 15_25177023_G_C
19 RUNX1_1 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 211_TL-2-105_3 / 253_XMD14-99_3 / 305_TPCA-1_3 / 225_Genentech Cpd 10_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 283_Omipalisib_2 / 221_TAK-715_2 / 223_ZSTK474_2 / 330_XMD13-2_3 / 303_PIK-93_3 / 326_GSK690693_3 / 136_Mitomycin-C_1 / 304_SB52334_3 / 301_PHA-793887_3 / 254_Quizartinib_2 / 252_WZ3105_3 / 346_THZ-2-102-1_3 erk_mapk / other / pi3k / mitosis / other / erk_mapk / rtk / other / mitosis / cell_cyc / mitosis / pi3k / jnk_p38 / pi3k / other / pi3k / pi3k / DNArep / rtk / cell_cyc / rtk / other / cell_cyc 1_26457907_T_G
20 UGT3A2_1 310_YM201636_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 252_WZ3105_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 299_OSI-027_2 / 256_JW-7-24-1_3 / 330_XMD13-2_3 / 152_CP466722_3 / 283_Omipalisib_2 / 271_VNLG/124_3 / 288_WHI-P97_3 / 1259_Talazoparib_3 / 286_KIN001-236_3 / 326_GSK690693_3 / 331_QL-X-138_3 / 223_ZSTK474_2 / 253_XMD14-99_3 / 290_KIN001-260_3 other / erk_mapk / other / other / rtk / mitosis / cell_cyc / pi3k / pi3k / tor / other / other / g_integrity / pi3k / chromatin / other / g_integrity / other / pi3k / other / pi3k / rtk / other 1_26457907_T_G
21 SLAIN1_2 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 281_Alectinib_2 / 226_GSK1070916_2 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 326_GSK690693_3 / 344_THZ-2-49_3 / 223_ZSTK474_2 / 256_JW-7-24-1_3 / 283_Omipalisib_2 / 299_OSI-027_2 / 305_TPCA-1_3 / 303_PIK-93_3 / 225_Genentech Cpd 10_3 / 346_THZ-2-102-1_3 / 152_CP466722_3 / 222_BX-912_3 other / pi3k / erk_mapk / rtk / mitosis / other / mitosis / other / pi3k / cell_cyc / pi3k / other / pi3k / tor / other / pi3k / mitosis / cell_cyc / g_integrity / pi3k 1_26457907_T_G / 22_21127217_C_G
22 TRPM4_3 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 283_Omipalisib_2 / 330_XMD13-2_3 / 1495_Olaparib_1 / 305_TPCA-1_3 / 304_SB52334_3 / 226_GSK1070916_2 / 257_NPK76-II-72-1_3 / 326_GSK690693_3 / 346_THZ-2-102-1_3 / 253_XMD14-99_3 / 271_VNLG/124_3 erk_mapk / other / cell_cyc / other / mitosis / other / g_integrity / pi3k / pi3k / pi3k / other / g_integrity / other / rtk / mitosis / mitosis / pi3k / cell_cyc / rtk / chromatin 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G
23 SLC24A3_1 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 271_VNLG/124_3 / 286_KIN001-236_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 253_XMD14-99_3 / 205_Avagacestat_2 / 281_Alectinib_2 / 326_GSK690693_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 298_OSI-930_2 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 1495_Olaparib_1 erk_mapk / other / cell_cyc / chromatin / other / g_integrity / pi3k / other / rtk / other / rtk / pi3k / other / rtk / rtk / mitosis / pi3k / other / other / g_integrity 22_22643666_C_G
24 NCKAP1L_1 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 256_JW-7-24-1_3 / 326_GSK690693_3 / 299_OSI-027_2 / 223_ZSTK474_2 / 304_SB52334_3 / 330_XMD13-2_3 / 283_Omipalisib_2 / 1259_Talazoparib_3 / 294_MPS-1-IN-1_3 / 331_QL-X-138_3 / 344_THZ-2-49_3 / 152_CP466722_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 271_VNLG/124_3 / 226_GSK1070916_2 erk_mapk / other / pi3k / other / other / pi3k / tor / pi3k / rtk / other / pi3k / g_integrity / mitosis / other / cell_cyc / g_integrity / pi3k / other / chromatin / mitosis 1_26457907_T_G
25 RAB32_3 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 326_GSK690693_3 / 252_WZ3105_3 / 222_BX-912_3 / 226_GSK1070916_2 / 290_KIN001-260_3 / 305_TPCA-1_3 / 330_XMD13-2_3 / 257_NPK76-II-72-1_3 / 263_FR-180204_3 / 281_Alectinib_2 / 256_JW-7-24-1_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 152_CP466722_3 / 254_Quizartinib_2 / 283_Omipalisib_2 mitosis / pi3k / other / pi3k / other / pi3k / mitosis / other / other / other / mitosis / erk_mapk / rtk / other / pi3k / cell_cyc / g_integrity / rtk / pi3k 1_26457907_T_G / 15_92992967_C_T / 5_141477711_A_G
26 E2F5_1 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 326_GSK690693_3 / 305_TPCA-1_3 / 226_GSK1070916_2 / 283_Omipalisib_2 / 290_KIN001-260_3 / 211_TL-2-105_3 / 304_SB52334_3 / 252_WZ3105_3 / 303_PIK-93_3 / 221_TAK-715_2 / 265_Tubastatin A_3 / 223_ZSTK474_2 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 erk_mapk / other / mitosis / pi3k / rtk / pi3k / other / mitosis / pi3k / other / erk_mapk / rtk / other / pi3k / jnk_p38 / chromatin / pi3k / mitosis / other 8_22080213_T_C
27 RBM11_5 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 226_GSK1070916_2 / 326_GSK690693_3 / 256_JW-7-24-1_3 / 1259_Talazoparib_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 223_ZSTK474_2 / 271_VNLG/124_3 / 253_XMD14-99_3 / 283_Omipalisib_2 other / erk_mapk / cell_cyc / other / other / pi3k / mitosis / rtk / mitosis / pi3k / other / g_integrity / other / pi3k / pi3k / chromatin / rtk / pi3k 1_26457907_T_G / 5_141432375_A_C / 12_52771095_C_G / 8_109483107_T_G / 22_18847351_G_C
28 JHDM1D_1 310_YM201636_3 / 279_BIX02189_3 / 252_WZ3105_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 263_FR-180204_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 286_KIN001-236_3 / 287_KIN001-244_3 / 223_ZSTK474_2 / 290_KIN001-260_3 / 288_WHI-P97_3 / 299_OSI-027_2 / 257_NPK76-II-72-1_3 / 253_XMD14-99_3 other / other / other / other / pi3k / pi3k / erk_mapk / other / rtk / other / pi3k / pi3k / other / other / tor / mitosis / rtk 22_21127217_C_G
29 SDC1_2 310_YM201636_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 211_TL-2-105_3 / 283_Omipalisib_2 / 305_TPCA-1_3 / 330_XMD13-2_3 / 290_KIN001-260_3 / 326_GSK690693_3 / 344_THZ-2-49_3 / 281_Alectinib_2 / 254_Quizartinib_2 / 263_FR-180204_3 other / other / mitosis / mitosis / pi3k / pi3k / cell_cyc / erk_mapk / pi3k / other / other / other / pi3k / cell_cyc / rtk / rtk / erk_mapk 1_26457907_T_G / 3_52520584_A_C
30 ENPP3_2 344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 303_PIK-93_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 346_THZ-2-102-1_3 / 226_GSK1070916_2 / 256_JW-7-24-1_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 281_Alectinib_2 / 331_QL-X-138_3 / 305_TPCA-1_3 cell_cyc / other / other / erk_mapk / other / pi3k / pi3k / pi3k / cell_cyc / mitosis / other / mitosis / pi3k / rtk / other / other 1_26457907_T_G / 22_22643666_C_G
31 RBM33_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 252_WZ3105_3 / 290_KIN001-260_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 346_THZ-2-102-1_3 / 305_TPCA-1_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 257_NPK76-II-72-1_3 / 299_OSI-027_2 / 331_QL-X-138_3 / 265_Tubastatin A_3 / 256_JW-7-24-1_3 / 330_XMD13-2_3 mitosis / erk_mapk / other / other / other / cell_cyc / cell_cyc / other / pi3k / pi3k / mitosis / tor / other / chromatin / other / other 1_26457907_T_G
32 MYOM2_1 263_FR-180204_3 / 310_YM201636_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 208_Ispinesib Mesylate_2 / 326_GSK690693_3 / 257_NPK76-II-72-1_3 / 221_TAK-715_2 / 290_KIN001-260_3 / 298_OSI-930_2 / 306_Fedratinib_2 / 344_THZ-2-49_3 erk_mapk / other / mitosis / mitosis / other / other / pi3k / other / mitosis / pi3k / mitosis / jnk_p38 / other / rtk / other / cell_cyc 1_26457907_T_G
33 ADRB1_1 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 326_GSK690693_3 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 290_KIN001-260_3 / 283_Omipalisib_2 / 185_Linsitinib_2 / 226_GSK1070916_2 / 305_TPCA-1_3 / 286_KIN001-236_3 / 221_TAK-715_2 erk_mapk / other / cell_cyc / mitosis / other / pi3k / rtk / pi3k / other / other / pi3k / igfr / mitosis / other / other / jnk_p38 1_26457907_T_G
34 FAM19A5_1 310_YM201636_3 / 253_XMD14-99_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 211_TL-2-105_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 254_Quizartinib_2 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 330_XMD13-2_3 / 304_SB52334_3 / 256_JW-7-24-1_3 / 281_Alectinib_2 / 224_AS605240_3 other / rtk / erk_mapk / pi3k / erk_mapk / pi3k / pi3k / rtk / other / mitosis / pi3k / other / rtk / other / rtk / pi3k 22_22643666_C_G
35 CDK6_2 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 254_Quizartinib_2 / 211_TL-2-105_3 / 283_Omipalisib_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 223_ZSTK474_2 / 224_AS605240_3 / 306_Fedratinib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 282_Pelitinib_2 / 225_Genentech Cpd 10_3 / 281_Alectinib_2 / 221_TAK-715_2 pi3k / rtk / rtk / erk_mapk / pi3k / mitosis / other / pi3k / pi3k / other / erk_mapk / other / egfr / mitosis / rtk / jnk_p38 6_31662176_A_G / 6_31662464_C_T
36 C1orf54_1 221_TAK-715_2 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 310_YM201636_3 / 341_Selisistat_3 / 298_OSI-930_2 / 330_XMD13-2_3 / 286_KIN001-236_3 / 346_THZ-2-102-1_3 / 328_SNX-2112_3 / 135_Gemcitabine_1 / 226_GSK1070916_2 / 260_NG-25_3 / 329_QL-XI-92_3 / 345_KIN001-270_3 / 292_Masitinib_1 jnk_p38 / pi3k / erk_mapk / other / other / rtk / other / other / cell_cyc / other / DNArep / mitosis / other / rtk / cell_cyc / rtk 8_22080213_T_C
37 HOOK1_1 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 271_VNLG/124_3 / 330_XMD13-2_3 / 304_SB52334_3 / 303_PIK-93_3 / 283_Omipalisib_2 / 226_GSK1070916_2 / 299_OSI-027_2 / 208_Ispinesib Mesylate_2 / 305_TPCA-1_3 / 1495_Olaparib_1 erk_mapk / cell_cyc / other / other / mitosis / g_integrity / chromatin / other / rtk / pi3k / pi3k / mitosis / tor / mitosis / other / g_integrity 1_26457907_T_G
38 EVI2A_1 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 221_TAK-715_2 / 283_Omipalisib_2 / 179_5-Fluorouracil_1 / 326_GSK690693_3 / 253_XMD14-99_3 / 330_XMD13-2_3 / 223_ZSTK474_2 / 238_Idelalisib_1 / 136_Mitomycin-C_1 / 305_TPCA-1_3 pi3k / mitosis / other / mitosis / erk_mapk / jnk_p38 / pi3k / DNArep / pi3k / rtk / other / pi3k / pi3k / DNArep / other 1_26457907_T_G
39 KDSR_1 310_YM201636_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 287_KIN001-244_3 / 344_THZ-2-49_3 / 328_SNX-2112_3 / 304_SB52334_3 / 330_XMD13-2_3 / 271_VNLG/124_3 / 1259_Talazoparib_3 other / pi3k / cell_cyc / erk_mapk / other / mitosis / other / mitosis / pi3k / cell_cyc / other / rtk / other / chromatin / g_integrity 22_21127217_C_G
40 TRIM69_1 310_YM201636_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 136_Mitomycin-C_1 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 287_KIN001-244_3 / 328_SNX-2112_3 / 344_THZ-2-49_3 / 299_OSI-027_2 / 257_NPK76-II-72-1_3 / 263_FR-180204_3 / 1018_Veliparib_2 other / mitosis / other / DNArep / DNArep / other / other / pi3k / pi3k / other / cell_cyc / tor / mitosis / erk_mapk / g_integrity 22_21127217_C_G
41 FAM69A_1 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 1017_Olaparib_2 / 303_PIK-93_3 / 326_GSK690693_3 / 257_NPK76-II-72-1_3 / 304_SB52334_3 / 301_PHA-793887_3 / 253_XMD14-99_3 / 290_KIN001-260_3 / 226_GSK1070916_2 / 346_THZ-2-102-1_3 / 208_Ispinesib Mesylate_2 other / mitosis / other / erk_mapk / g_integrity / pi3k / pi3k / mitosis / rtk / cell_cyc / rtk / other / mitosis / cell_cyc / mitosis 4_105679196_A_C
42 MCF2_1 310_YM201636_3 / 344_THZ-2-49_3 / 290_KIN001-260_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 276_CAY10603_3 / 263_FR-180204_3 / 221_TAK-715_2 / 1259_Talazoparib_3 / 257_NPK76-II-72-1_3 / 274_Belinostat_1 / 253_XMD14-99_3 / 273_CUDC-101_2 / 228_AKT_inhibitor_VIII_3 other / cell_cyc / other / mitosis / mitosis / other / chromatin / erk_mapk / jnk_p38 / g_integrity / mitosis / chromatin / rtk / chromatin / pi3k 15_42142087_A_C
43 DNMT3A_1 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 286_KIN001-236_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 136_Mitomycin-C_1 / 326_GSK690693_3 / 305_TPCA-1_3 / 304_SB52334_3 / 205_Avagacestat_2 / 1091_BMS-536924_3 erk_mapk / cell_cyc / other / other / mitosis / g_integrity / pi3k / other / other / DNArep / pi3k / other / rtk / other / igfr 1_26457907_T_G
44 RAP1GAP_1 226_GSK1070916_2 / 310_YM201636_3 / 263_FR-180204_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 326_GSK690693_3 / 305_TPCA-1_3 / 252_WZ3105_3 / 290_KIN001-260_3 / 288_WHI-P97_3 / 299_OSI-027_2 mitosis / other / erk_mapk / mitosis / other / cell_cyc / mitosis / pi3k / pi3k / other / other / other / other / tor 1_26457907_T_G
45 GCNT1_2 221_TAK-715_2 / 330_XMD13-2_3 / 292_Masitinib_1 / 310_YM201636_3 / 208_Ispinesib Mesylate_2 / 301_PHA-793887_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 286_KIN001-236_3 / 298_OSI-930_2 / 263_FR-180204_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 jnk_p38 / other / rtk / other / mitosis / cell_cyc / g_integrity / pi3k / rtk / other / rtk / erk_mapk / cell_cyc / mitosis 22_22643666_C_G / 1_26457907_T_G
46 ACVR2B_1 228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 298_OSI-930_2 / 226_GSK1070916_2 / 330_XMD13-2_3 / 283_Omipalisib_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 253_XMD14-99_3 / 326_GSK690693_3 / 211_TL-2-105_3 / 208_Ispinesib Mesylate_2 / 225_Genentech Cpd 10_3 / 281_Alectinib_2 pi3k / jnk_p38 / rtk / mitosis / other / pi3k / mitosis / other / rtk / pi3k / erk_mapk / mitosis / mitosis / rtk 20_10639627_G_A
47 FLII_1 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 257_NPK76-II-72-1_3 / 263_FR-180204_3 / 226_GSK1070916_2 / 265_Tubastatin A_3 / 208_Ispinesib Mesylate_2 / 330_XMD13-2_3 / 288_WHI-P97_3 / 286_KIN001-236_3 / 252_WZ3105_3 / 305_TPCA-1_3 mitosis / other / cell_cyc / other / mitosis / erk_mapk / mitosis / chromatin / mitosis / other / other / other / other / other 3_52520584_A_C
48 TGS1_1 326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 330_XMD13-2_3 / 226_GSK1070916_2 / 253_XMD14-99_3 / 228_AKT_inhibitor_VIII_3 / 256_JW-7-24-1_3 / 279_BIX02189_3 pi3k / erk_mapk / other / mitosis / mitosis / pi3k / other / rtk / other / mitosis / rtk / pi3k / other / other 12_52771095_C_G
49 XG_2 310_YM201636_3 / 288_WHI-P97_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 304_SB52334_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 303_PIK-93_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 299_OSI-027_2 other / other / other / erk_mapk / mitosis / other / rtk / cell_cyc / other / pi3k / pi3k / other / tor 22_21127217_C_G / 1_26457907_T_G
50 PCDH17_2 344_THZ-2-49_3 / 281_Alectinib_2 / 252_WZ3105_3 / 330_XMD13-2_3 / 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 256_JW-7-24-1_3 / 326_GSK690693_3 / 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 cell_cyc / rtk / other / other / other / erk_mapk / mitosis / pi3k / other / pi3k / mitosis / pi3k / pi3k 1_26457907_T_G / 5_141432375_A_C
51 FCGRT_4 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 326_GSK690693_3 / 346_THZ-2-102-1_3 / 257_NPK76-II-72-1_3 other / erk_mapk / cell_cyc / mitosis / other / g_integrity / pi3k / other / pi3k / other / pi3k / cell_cyc / mitosis 1_26457907_T_G / 22_22643666_C_G / 5_141432375_A_C / 22_21127217_C_G
52 PPAPDC2_5 263_FR-180204_3 / 310_YM201636_3 / 1259_Talazoparib_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 1008_Methotrexate_1 / 290_KIN001-260_3 / 303_PIK-93_3 / 300_CX-5461_3 erk_mapk / other / g_integrity / mitosis / cell_cyc / other / other / other / pi3k / DNArep / other / pi3k / other 1_26457907_T_G / 15_42142087_A_C / 19_3179506_A_C / 8_22080213_T_C / 22_22643666_C_G
53 OTUD1_1 310_YM201636_3 / 252_WZ3105_3 / 306_Fedratinib_2 / 263_FR-180204_3 / 256_JW-7-24-1_3 / 254_Quizartinib_2 / 304_SB52334_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 225_Genentech Cpd 10_3 / 255_CP724714_2 / 271_VNLG/124_3 other / other / other / erk_mapk / other / rtk / rtk / pi3k / other / other / mitosis / egfr / chromatin 3_128992964_T_G
54 IRS2_2 344_THZ-2-49_3 / 310_YM201636_3 / 263_FR-180204_3 / 303_PIK-93_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 305_TPCA-1_3 / 304_SB52334_3 / 346_THZ-2-102-1_3 cell_cyc / other / erk_mapk / pi3k / other / mitosis / pi3k / mitosis / other / other / rtk / cell_cyc 1_26457907_T_G / 22_22643666_C_G
55 AKAP7_1 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 290_KIN001-260_3 / 305_TPCA-1_3 / 292_Masitinib_1 / 208_Ispinesib Mesylate_2 / 299_OSI-027_2 erk_mapk / other / mitosis / cell_cyc / other / pi3k / other / other / other / rtk / mitosis / tor 1_26457907_T_G
56 PCMTD2_1 304_SB52334_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 136_Mitomycin-C_1 / 252_WZ3105_3 / 152_CP466722_3 / 303_PIK-93_3 / 178_BAY-61-3606_3 rtk / mitosis / other / pi3k / erk_mapk / other / pi3k / DNArep / other / g_integrity / pi3k / other 1_26457907_T_G
57 ANXA11_1 305_TPCA-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 279_BIX02189_3 / 257_NPK76-II-72-1_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 281_Alectinib_2 / 252_WZ3105_3 / 290_KIN001-260_3 other / other / erk_mapk / mitosis / other / mitosis / pi3k / pi3k / rtk / rtk / other / other 1_26457907_T_G
58 CYP4F22_1 310_YM201636_3 / 330_XMD13-2_3 / 211_TL-2-105_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 326_GSK690693_3 / 305_TPCA-1_3 other / other / erk_mapk / pi3k / erk_mapk / other / mitosis / mitosis / mitosis / cell_cyc / pi3k / other 22_21127217_C_G
59 FAH_1 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 252_WZ3105_3 / 303_PIK-93_3 / 291_KIN001-266_3 / 330_XMD13-2_3 cell_cyc / mitosis / other / erk_mapk / other / other / mitosis / other / other / pi3k / other / other 22_22643666_C_G
60 PRSS35_1 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 305_TPCA-1_3 / 256_JW-7-24-1_3 / 1008_Methotrexate_1 / 1259_Talazoparib_3 erk_mapk / other / pi3k / other / other / other / mitosis / cell_cyc / other / other / DNArep / g_integrity 1_26457907_T_G
61 ARID2_1 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 erk_mapk / other / mitosis / other / mitosis / cell_cyc / pi3k / pi3k / other / other / mitosis 1_26457907_T_G
62 GBE1_2 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 226_GSK1070916_2 / 136_Mitomycin-C_1 / 330_XMD13-2_3 / 304_SB52334_3 / 303_PIK-93_3 erk_mapk / mitosis / other / other / pi3k / pi3k / mitosis / DNArep / other / rtk / pi3k 1_26457907_T_G / 22_22643666_C_G
63 FEZF1_2 310_YM201636_3 / 263_FR-180204_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 326_GSK690693_3 / 330_XMD13-2_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 other / erk_mapk / other / g_integrity / pi3k / other / mitosis / cell_cyc / mitosis / pi3k / other 1_26457907_T_G / 22_22643666_C_G
64 ACACB_2 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 1008_Methotrexate_1 / 252_WZ3105_3 / 326_GSK690693_3 / 222_BX-912_3 / 303_PIK-93_3 / 304_SB52334_3 pi3k / other / mitosis / pi3k / erk_mapk / DNArep / other / pi3k / pi3k / pi3k / rtk 1_26457907_T_G / 22_18847351_G_C
65 CUX2_1 330_XMD13-2_3 / 310_YM201636_3 / 299_OSI-027_2 / 304_SB52334_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 283_Omipalisib_2 / 331_QL-X-138_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 other / other / tor / rtk / other / erk_mapk / pi3k / other / pi3k / pi3k / mitosis 22_21127217_C_G
66 H2AFY2_1 1259_Talazoparib_3 / 263_FR-180204_3 / 310_YM201636_3 / 1495_Olaparib_1 / 136_Mitomycin-C_1 / 330_XMD13-2_3 / 271_VNLG/124_3 / 344_THZ-2-49_3 / 221_TAK-715_2 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 g_integrity / erk_mapk / other / g_integrity / DNArep / other / chromatin / cell_cyc / jnk_p38 / mitosis / mitosis 22_22643666_C_G
67 SCNN1G_1 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 288_WHI-P97_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 erk_mapk / other / cell_cyc / other / g_integrity / pi3k / other / jnk_p38 / other / mitosis / pi3k 1_26457907_T_G
68 MICAL2_1 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 / 310_YM201636_3 / 283_Omipalisib_2 / 211_TL-2-105_3 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 330_XMD13-2_3 / 263_FR-180204_3 / 254_Quizartinib_2 pi3k / pi3k / other / pi3k / erk_mapk / rtk / mitosis / jnk_p38 / other / erk_mapk / rtk 6_151015603_C_G
69 SWT1_2 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 253_XMD14-99_3 / 211_TL-2-105_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 283_Omipalisib_2 / 252_WZ3105_3 / 226_GSK1070916_2 other / pi3k / cell_cyc / rtk / erk_mapk / erk_mapk / other / jnk_p38 / pi3k / other / mitosis 1_26457907_T_G / 8_109483107_T_G
70 PDE6B_1 286_KIN001-236_3 / 263_FR-180204_3 / 1259_Talazoparib_3 / 310_YM201636_3 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 206_Ruxolitinib_1 / 1012_Vorinostat_1 / 330_XMD13-2_3 / 341_Selisistat_3 other / erk_mapk / g_integrity / other / rtk / pi3k / mitosis / other / chromatin / other / other 15_42142087_A_C
71 FUT11_4 310_YM201636_3 / 288_WHI-P97_3 / 330_XMD13-2_3 / 286_KIN001-236_3 / 291_KIN001-266_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / other / other / other / other / cell_cyc / pi3k / rtk / other / mitosis 1_26457907_T_G / 22_24252424_G_C / 22_21127217_C_G / 22_22643666_C_G
72 CRMP1_2 299_OSI-027_2 / 310_YM201636_3 / 256_JW-7-24-1_3 / 305_TPCA-1_3 / 274_Belinostat_1 / 263_FR-180204_3 / 276_CAY10603_3 / 330_XMD13-2_3 / 226_GSK1070916_2 / 272_AR-42_2 tor / other / other / other / chromatin / erk_mapk / chromatin / other / mitosis / chromatin 22_21127217_C_G / 1_26457907_T_G
73 ATP2B3_2 281_Alectinib_2 / 310_YM201636_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 305_TPCA-1_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 290_KIN001-260_3 rtk / other / other / pi3k / mitosis / mitosis / other / erk_mapk / cell_cyc / other 1_26457907_T_G / 17_7604041_A_C
74 KLHL23_2 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 253_XMD14-99_3 / 281_Alectinib_2 / 304_SB52334_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 326_GSK690693_3 erk_mapk / mitosis / pi3k / other / rtk / rtk / rtk / other / igfr / pi3k 1_26457907_T_G / 5_141432375_A_C
75 PNMAL1_1 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 344_THZ-2-49_3 / 346_THZ-2-102-1_3 / 283_Omipalisib_2 / 261_TL-1-85_3 / 228_AKT_inhibitor_VIII_3 other / mitosis / mitosis / pi3k / other / cell_cyc / cell_cyc / pi3k / other / pi3k 1_26457907_T_G
76 DPP9_1 263_FR-180204_3 / 1008_Methotrexate_1 / 185_Linsitinib_2 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 / 304_SB52334_3 / 326_GSK690693_3 erk_mapk / DNArep / igfr / pi3k / mitosis / mitosis / other / other / rtk / pi3k 22_21127217_C_G
77 GPC2_1 228_AKT_inhibitor_VIII_3 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 / 330_XMD13-2_3 / 283_Omipalisib_2 / 226_GSK1070916_2 / 252_WZ3105_3 pi3k / igfr / mitosis / pi3k / erk_mapk / other / other / pi3k / mitosis / other 5_141432375_A_C
78 RBM27_1 330_XMD13-2_3 / 265_Tubastatin A_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 271_VNLG/124_3 / 326_GSK690693_3 / 273_CUDC-101_2 / 226_GSK1070916_2 / 310_YM201636_3 / 263_FR-180204_3 other / chromatin / cell_cyc / mitosis / chromatin / pi3k / chromatin / mitosis / other / erk_mapk 19_48617887_T_G
79 HOXD13_1 344_THZ-2-49_3 / 263_FR-180204_3 / 298_OSI-930_2 / 1248_Daporinad_3 / 1259_Talazoparib_3 / 1091_BMS-536924_3 / 310_YM201636_3 / 136_Mitomycin-C_1 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 cell_cyc / erk_mapk / rtk / metabol / g_integrity / igfr / other / DNArep / pi3k / mitosis 1_26457907_T_G
80 TFCP2_1 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 326_GSK690693_3 / 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 252_WZ3105_3 / 298_OSI-930_2 / 330_XMD13-2_3 mitosis / mitosis / erk_mapk / pi3k / rtk / pi3k / other / other / rtk / other 19_55796171_G_T
81 MLC1_2 310_YM201636_3 / 1011_Navitoclax_2 / 344_THZ-2-49_3 / 263_FR-180204_3 / 303_PIK-93_3 / 288_WHI-P97_3 / 228_AKT_inhibitor_VIII_3 / 346_THZ-2-102-1_3 / 252_WZ3105_3 other / apop / cell_cyc / erk_mapk / pi3k / other / pi3k / cell_cyc / other 1_26457907_T_G / 7_72941936_T_C
82 NUDT10_1 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 326_GSK690693_3 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 281_Alectinib_2 other / pi3k / mitosis / pi3k / pi3k / other / mitosis / other / rtk 1_26457907_T_G
83 ABHD6_5 344_THZ-2-49_3 / 310_YM201636_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 273_CUDC-101_2 / 265_Tubastatin A_3 cell_cyc / other / other / pi3k / mitosis / other / mitosis / chromatin / chromatin 12_52771095_C_G / 1_26457907_T_G / 22_18847351_G_C / 5_141432375_A_C / 22_21127217_C_G
84 NDST4_2 310_YM201636_3 / 252_WZ3105_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 283_Omipalisib_2 other / other / erk_mapk / other / cell_cyc / pi3k / mitosis / other / pi3k 1_26457907_T_G / 1_219210601_T_G
85 POU3F2_5 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 226_GSK1070916_2 / 330_XMD13-2_3 / 263_FR-180204_3 / 346_THZ-2-102-1_3 / 257_NPK76-II-72-1_3 / 281_Alectinib_2 cell_cyc / other / other / mitosis / other / erk_mapk / cell_cyc / mitosis / rtk 1_26457907_T_G / 5_141432375_A_C / 1_219210601_T_G / 1_205381583_C_G / 3_52520584_A_C
86 RND2_1 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 305_TPCA-1_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 221_TAK-715_2 / 253_XMD14-99_3 erk_mapk / pi3k / other / other / rtk / mitosis / other / jnk_p38 / rtk 1_26457907_T_G
87 TEKT2_1 263_FR-180204_3 / 185_Linsitinib_2 / 344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 271_VNLG/124_3 erk_mapk / igfr / cell_cyc / other / other / pi3k / pi3k / mitosis / chromatin 1_26457907_T_G
88 RCOR1_1 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 erk_mapk / other / mitosis / cell_cyc / mitosis / pi3k / other / mitosis / other 1_176702776_TGAGAGAGA_T
89 SH3GLB1_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 1264_SGC0946_3 / 253_XMD14-99_3 / 265_Tubastatin A_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / mitosis / other / chromatin / rtk / chromatin / other / other / pi3k 22_22643666_C_G
90 ZCCHC5_1 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 283_Omipalisib_2 / 300_CX-5461_3 / 136_Mitomycin-C_1 / 208_Ispinesib Mesylate_2 / 299_OSI-027_2 / 302_PI-103_3 / 151_QS11_3 mitosis / DNArep / pi3k / other / DNArep / mitosis / tor / pi3k / other 22_22643666_C_G
91 EVI2B_1 310_YM201636_3 / 326_GSK690693_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 136_Mitomycin-C_1 / 344_THZ-2-49_3 / 211_TL-2-105_3 other / pi3k / g_integrity / mitosis / rtk / pi3k / DNArep / cell_cyc / erk_mapk 10_46462341_C_A
92 EPC1_2 310_YM201636_3 / 263_FR-180204_3 / 1259_Talazoparib_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 303_PIK-93_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 226_GSK1070916_2 other / erk_mapk / g_integrity / other / other / pi3k / mitosis / other / mitosis 19_6744459_C_G / 19_42723940_A_C
93 VAX1_2 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 other / erk_mapk / cell_cyc / pi3k / pi3k / other / mitosis / mitosis 1_26457907_T_G / 22_21127217_C_G
94 DLG2_3 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 185_Linsitinib_2 / 304_SB52334_3 / 305_TPCA-1_3 erk_mapk / other / mitosis / pi3k / cell_cyc / igfr / rtk / other 22_21127217_C_G / 22_18847351_G_C / 1_26457907_T_G
95 PPP1R1A_2 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 other / erk_mapk / cell_cyc / pi3k / other / other / pi3k / mitosis 1_26457907_T_G / 5_141432375_A_C
96 EFNB1_1 344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 256_JW-7-24-1_3 / 263_FR-180204_3 / 299_OSI-027_2 / 330_XMD13-2_3 / 281_Alectinib_2 cell_cyc / other / other / other / erk_mapk / tor / other / rtk 1_26457907_T_G
97 POU3F1_2 263_FR-180204_3 / 310_YM201636_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / other / g_integrity / mitosis / mitosis / pi3k / other / pi3k 1_26457907_T_G / 22_22643666_C_G
98 JPH1_2 263_FR-180204_3 / 344_THZ-2-49_3 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 310_YM201636_3 / 252_WZ3105_3 / 298_OSI-930_2 erk_mapk / cell_cyc / igfr / mitosis / pi3k / other / other / rtk 1_26457907_T_G / 19_32643405_T_C
99 LGALS3_5 281_Alectinib_2 / 330_XMD13-2_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 326_GSK690693_3 / 252_WZ3105_3 / 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 rtk / other / other / cell_cyc / pi3k / other / mitosis / pi3k 1_26457907_T_G / 5_141432375_A_C / 3_51333222_A_C / 7_100760409_A_C / 22_24252424_G_C
100 LRRC4B_1 310_YM201636_3 / 303_PIK-93_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 283_Omipalisib_2 / 346_THZ-2-102-1_3 / 226_GSK1070916_2 other / pi3k / erk_mapk / pi3k / other / pi3k / cell_cyc / mitosis 22_21127217_C_G
101 ARHGAP19_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 330_XMD13-2_3 / 305_TPCA-1_3 / 226_GSK1070916_2 erk_mapk / mitosis / other / pi3k / jnk_p38 / other / other / mitosis 22_22643666_C_G
102 MYL9_1 310_YM201636_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 other / other / cell_cyc / mitosis / mitosis / pi3k / erk_mapk 1_26457907_T_G
103 TMEM170B_1 294_MPS-1-IN-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 326_GSK690693_3 mitosis / other / erk_mapk / pi3k / rtk / other / pi3k 1_26457907_T_G
104 CSAD_1 326_GSK690693_3 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 pi3k / pi3k / other / mitosis / mitosis / pi3k / other 1_26457907_T_G
105 ASGR1_5 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 288_WHI-P97_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 erk_mapk / other / cell_cyc / other / pi3k / mitosis / other 22_22643666_C_G / 1_26457907_T_G / 15_42142087_A_C / 22_21127217_C_G / 5_141432375_A_C
106 KIAA1958_1 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 223_ZSTK474_2 / 226_GSK1070916_2 / 305_TPCA-1_3 other / erk_mapk / mitosis / pi3k / pi3k / mitosis / other 1_26457907_T_G
107 NPW_2 310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 226_GSK1070916_2 / 288_WHI-P97_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 other / cell_cyc / erk_mapk / mitosis / other / other / pi3k 1_26457907_T_G / 3_52520584_A_C
108 CAP1_1 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 136_Mitomycin-C_1 / 286_KIN001-236_3 erk_mapk / other / mitosis / other / other / DNArep / other 1_26457907_T_G
109 SIAH3_1 344_THZ-2-49_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 286_KIN001-236_3 / 253_XMD14-99_3 cell_cyc / other / mitosis / other / erk_mapk / other / rtk 1_26457907_T_G
110 PALM3_1 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 271_VNLG/124_3 / 304_SB52334_3 erk_mapk / pi3k / mitosis / pi3k / pi3k / chromatin / rtk 22_22643666_C_G
111 STMN3_1 303_PIK-93_3 / 260_NG-25_3 / 300_CX-5461_3 / 287_KIN001-244_3 / 305_TPCA-1_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 pi3k / other / other / pi3k / other / other / mitosis 6_110102054_T_G
112 TMEM81_1 263_FR-180204_3 / 344_THZ-2-49_3 / 326_GSK690693_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 226_GSK1070916_2 erk_mapk / cell_cyc / pi3k / other / mitosis / other / mitosis 19_7056560_G_T
113 SPATA6L_2 263_FR-180204_3 / 1259_Talazoparib_3 / 310_YM201636_3 / 271_VNLG/124_3 / 286_KIN001-236_3 / 304_SB52334_3 / 1008_Methotrexate_1 erk_mapk / g_integrity / other / chromatin / other / rtk / DNArep 8_1678462_A_C / 1_26457907_T_G
114 CSRP2BP_5 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 326_GSK690693_3 pi3k / other / cell_cyc / mitosis / mitosis / erk_mapk / pi3k 1_26457907_T_G / 17_65225089_T_C / 1_205381583_C_G / 17_7318141_T_G / 16_22266423_T_C
115 MAP2K6_1 228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 253_XMD14-99_3 / 310_YM201636_3 pi3k / jnk_p38 / erk_mapk / mitosis / other / rtk / other 6_151015603_C_G
116 HOXB13_1 263_FR-180204_3 / 1008_Methotrexate_1 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 286_KIN001-236_3 erk_mapk / DNArep / mitosis / other / pi3k / g_integrity / other 1_26457907_T_G
117 RBM12B_1 326_GSK690693_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 290_KIN001-260_3 / 253_XMD14-99_3 / 305_TPCA-1_3 pi3k / mitosis / rtk / erk_mapk / other / rtk / other 8_131984112_C_T
118 ADRB3_1 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 erk_mapk / other / cell_cyc / pi3k / mitosis / other 1_26457907_T_G
119 LUC7L_5 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 326_GSK690693_3 erk_mapk / pi3k / other / mitosis / rtk / pi3k 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 15_50544697_C_A / 5_141432375_A_C
120 ITM2A_1 344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 256_JW-7-24-1_3 cell_cyc / erk_mapk / other / other / other / other 1_26457907_T_G
121 ICAM4_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 298_OSI-930_2 / 344_THZ-2-49_3 erk_mapk / mitosis / other / pi3k / rtk / cell_cyc 1_26457907_T_G
122 HMCN1_1 310_YM201636_3 / 252_WZ3105_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 344_THZ-2-49_3 other / other / erk_mapk / pi3k / pi3k / cell_cyc 1_26457907_T_G
123 ZNF397_4 310_YM201636_3 / 276_CAY10603_3 / 245_UNC0638_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 303_PIK-93_3 other / chromatin / chromatin / mitosis / erk_mapk / pi3k 22_22643666_C_G / 22_21127217_C_G / 15_56693096_A_C / 1_26457907_T_G
124 DRAP1_1 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 290_KIN001-260_3 other / mitosis / erk_mapk / other / pi3k / other 1_26457907_T_G
125 DTX3L_1 305_TPCA-1_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 257_NPK76-II-72-1_3 / 290_KIN001-260_3 other / other / mitosis / erk_mapk / mitosis / other 1_26457907_T_G
126 NUDT11_5 310_YM201636_3 / 281_Alectinib_2 / 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / rtk / cell_cyc / mitosis / other / mitosis 1_26457907_T_G / 5_141432375_A_C / 12_52771095_C_G / 1_219210601_T_G / 22_18847351_G_C
127 ADAM19_3 265_Tubastatin A_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 310_YM201636_3 / 271_VNLG/124_3 chromatin / erk_mapk / mitosis / other / other / chromatin 22_21127217_C_G / 22_21283300_G_C / 14_68882917_A_G
128 HS3ST4_2 263_FR-180204_3 / 310_YM201636_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 erk_mapk / other / pi3k / pi3k / other / cell_cyc 1_26457907_T_G / 12_52771095_C_G
129 CRIPAK_4 346_THZ-2-102-1_3 / 261_TL-1-85_3 / 303_PIK-93_3 / 287_KIN001-244_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 cell_cyc / other / pi3k / pi3k / mitosis / other 9_137101572_A_C / 4_48557504_A_G / 6_160247199_T_G / 7_44697564_T_G
130 OLFM3_1 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 298_OSI-930_2 erk_mapk / cell_cyc / other / other / other / rtk 22_22643666_C_G
131 LMO2_4 344_THZ-2-49_3 / 263_FR-180204_3 / 281_Alectinib_2 / 310_YM201636_3 / 1259_Talazoparib_3 / 252_WZ3105_3 cell_cyc / erk_mapk / rtk / other / g_integrity / other 5_141432375_A_C / 1_26457907_T_G / 11_1246628_A_C / 15_25177023_G_C
132 SALL2_1 263_FR-180204_3 / 1008_Methotrexate_1 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / DNArep / other / mitosis / g_integrity / pi3k 22_22643666_C_G
133 SLC35F3_1 1495_Olaparib_1 / 330_XMD13-2_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 310_YM201636_3 g_integrity / other / g_integrity / cell_cyc / other / other 15_42142087_A_C
134 RHOH_1 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 344_THZ-2-49_3 / 305_TPCA-1_3 other / erk_mapk / mitosis / other / cell_cyc / other 22_21127217_C_G
135 MED23_1 344_THZ-2-49_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 265_Tubastatin A_3 / 310_YM201636_3 / 290_KIN001-260_3 cell_cyc / erk_mapk / mitosis / chromatin / other / other 15_42142087_A_C
136 ALS2CR8_2 310_YM201636_3 / 271_VNLG/124_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 326_GSK690693_3 / 283_Omipalisib_2 other / chromatin / pi3k / g_integrity / pi3k / pi3k 7_5300364_T_G / 11_64118302_A_C
137 PDS5B_1 226_GSK1070916_2 / 281_Alectinib_2 / 253_XMD14-99_3 / 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 / 263_FR-180204_3 mitosis / rtk / rtk / pi3k / pi3k / erk_mapk 19_5654163_A_C
138 POU4F1_1 252_WZ3105_3 / 310_YM201636_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 222_BX-912_3 / 330_XMD13-2_3 other / other / mitosis / cell_cyc / pi3k / other X_149503442_T_G
139 LINGO1_4 263_FR-180204_3 / 310_YM201636_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 294_MPS-1-IN-1_3 erk_mapk / other / other / other / mitosis 22_22643666_C_G / 22_21127217_C_G / 1_26457907_T_G / 11_66624536_A_C
140 EZH2_2 310_YM201636_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 other / pi3k / mitosis / other / pi3k 1_26457907_T_G / 22_18847351_G_C
141 ZNF786_5 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 310_YM201636_3 / 326_GSK690693_3 other / mitosis / pi3k / other / pi3k 1_26457907_T_G / 17_7604041_A_C / 17_78120770_A_C / 22_30937565_T_G / 16_25177910_T_G
142 SLCO5A1_1 263_FR-180204_3 / 310_YM201636_3 / 304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 erk_mapk / other / rtk / other / mitosis 1_26457907_T_G
143 DKK2_1 310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 299_OSI-027_2 / 294_MPS-1-IN-1_3 other / cell_cyc / erk_mapk / tor / mitosis 1_26457907_T_G
144 ATP11C_1 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 273_CUDC-101_2 / 330_XMD13-2_3 cell_cyc / other / other / chromatin / other 1_26457907_T_G
145 KMO_1 310_YM201636_3 / 263_FR-180204_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 other / erk_mapk / pi3k / other / mitosis 22_21127217_C_G
146 SPOCD1_1 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 253_XMD14-99_3 / 286_KIN001-236_3 erk_mapk / pi3k / other / rtk / other 1_26457907_T_G
147 LMO3_1 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 223_ZSTK474_2 / 252_WZ3105_3 / 211_TL-2-105_3 pi3k / other / pi3k / other / erk_mapk 1_26457907_T_G
148 SUCLG2_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1242_(5Z)-7-Oxozeaenol_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 erk_mapk / erk_mapk / other / erk_mapk / erk_mapk 3_160423378_C_T
149 CDC42EP3_1 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 226_GSK1070916_2 mitosis / pi3k / erk_mapk / other / mitosis 22_21283300_G_C
150 VIM_2 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk 13_99295007_C_T / 13_99314037_A_G
151 KIAA1456_5 263_FR-180204_3 / 288_WHI-P97_3 / 344_THZ-2-49_3 / 310_YM201636_3 erk_mapk / other / cell_cyc / other 1_26457907_T_G / 22_21127217_C_G / 22_22643666_C_G / 3_52520584_A_C / 15_25177023_G_C
152 ATP1A1_1 344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3 cell_cyc / erk_mapk / other / other 1_26457907_T_G
153 EFHD2_3 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 310_YM201636_3 erk_mapk / mitosis / other / other 1_26457907_T_G / 19_3179506_A_C / 12_48769033_A_C
154 NPY1R_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 310_YM201636_3 erk_mapk / mitosis / cell_cyc / other 1_26457907_T_G
155 PTPN13_1 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 330_XMD13-2_3 cell_cyc / other / other / other 1_26457907_T_G
156 SOX11_3 344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 cell_cyc / erk_mapk / other / pi3k 1_26457907_T_G / 22_21127217_C_G / 5_141432375_A_C
157 RAVER2_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 226_GSK1070916_2 erk_mapk / mitosis / other / mitosis 1_26457907_T_G
158 CD44_3 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 erk_mapk / mitosis / pi3k / mitosis 1_149813302_A_C / 1_26457907_T_G / 6_151015603_C_G
159 WIPI1_1 263_FR-180204_3 / 281_Alectinib_2 / 310_YM201636_3 / 305_TPCA-1_3 erk_mapk / rtk / other / other 1_26457907_T_G
160 MEIG1_1 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 281_Alectinib_2 other / pi3k / cell_cyc / rtk 5_141636680_A_C
161 ITGAV_1 1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 3_180647255_T_TA
162 WASF1_2 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 erk_mapk / mitosis / other / other 22_22643666_C_G / 22_21127217_C_G
163 SEPT5_1 263_FR-180204_3 / 310_YM201636_3 / 304_SB52334_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / other / rtk / pi3k 1_26457907_T_G
164 ZNF703_4 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 304_SB52334_3 erk_mapk / other / cell_cyc / rtk 15_42142087_A_C / 19_3179506_A_C / 22_22643666_C_G / 10_71362188_T_C
165 RCAN1_1 310_YM201636_3 / 1259_Talazoparib_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 other / g_integrity / erk_mapk / pi3k 22_22643666_C_G
166 MEIS1_1 310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 330_XMD13-2_3 other / cell_cyc / erk_mapk / other 11_1246619_A_C
167 DOCK9_2 1014_Refametinib_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1372_Trametinib_1 erk_mapk / erk_mapk / erk_mapk / erk_mapk 17_80065379_A_G / 2_87800520_G_A
168 MAP2K1_1 301_PHA-793887_3 / 1259_Talazoparib_3 / 263_FR-180204_3 / 330_XMD13-2_3 cell_cyc / g_integrity / erk_mapk / other 22_21127217_C_G
169 BAZ2A_1 263_FR-180204_3 / 298_OSI-930_2 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / rtk / mitosis / pi3k 19_46321845_A_C
170 TMEM70_2 252_WZ3105_3 / 310_YM201636_3 / 303_PIK-93_3 / 301_PHA-793887_3 other / other / pi3k / cell_cyc 1_26457907_T_G / 10_35032524_A_C
171 CSRP3_1 294_MPS-1-IN-1_3 / 328_SNX-2112_3 / 346_THZ-2-102-1_3 / 310_YM201636_3 mitosis / other / cell_cyc / other 2_112722995_T_G
172 MSRB3_1 1372_Trametinib_1 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk / erk_mapk 22_37816755_A_G
173 PTGER2_1 263_FR-180204_3 / 253_XMD14-99_3 / 306_Fedratinib_2 / 1495_Olaparib_1 erk_mapk / rtk / other / g_integrity 20_49068783_G_C
174 ARHGAP44_2 1248_Daporinad_3 / 344_THZ-2-49_3 / 1495_Olaparib_1 / 1259_Talazoparib_3 metabol / cell_cyc / g_integrity / g_integrity 16_55810697_G_T / 16_55813139_C_T
175 TTC7A_2 326_GSK690693_3 / 310_YM201636_3 / 330_XMD13-2_3 / 254_Quizartinib_2 pi3k / other / other / rtk 11_92353347_C_T / 11_92353483_G_A
176 SLC35F1_1 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 other / erk_mapk / cell_cyc 1_26457907_T_G
177 KRT25_4 330_XMD13-2_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 other / other / mitosis 22_21127217_C_G / 1_26457907_T_G / 22_22643666_C_G / 22_24658344_C_G
178 PAX7_1 263_FR-180204_3 / 310_YM201636_3 / 326_GSK690693_3 erk_mapk / other / pi3k 1_26457907_T_G
179 ENC1_1 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3 erk_mapk / other / other 1_26457907_T_G
180 ERO1L_3 281_Alectinib_2 / 263_FR-180204_3 / 326_GSK690693_3 rtk / erk_mapk / pi3k 1_26457907_T_G / 5_141432375_A_C / 10_6515090_A_C
181 KANSL2_2 281_Alectinib_2 / 226_GSK1070916_2 / 310_YM201636_3 rtk / mitosis / other 1_26457907_T_G / 12_94248247_C_T
182 RPN1_3 344_THZ-2-49_3 / 286_KIN001-236_3 / 310_YM201636_3 cell_cyc / other / other 22_22643666_C_G / 5_141432375_A_C / 1_26457907_T_G
183 PTGER3_2 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 cell_cyc / other / other 1_26457907_T_G / 1_219210601_T_G
184 CACHD1_2 288_WHI-P97_3 / 263_FR-180204_3 / 344_THZ-2-49_3 other / erk_mapk / cell_cyc 1_26457907_T_G / 2_119366546_A_G
185 VPS37D_2 226_GSK1070916_2 / 305_TPCA-1_3 / 303_PIK-93_3 mitosis / other / pi3k 7_72941936_T_C / 1_26457907_T_G
186 ZDHHC17_1 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / mitosis / erk_mapk 1_26457907_T_G
187 TMEM9B_2 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 263_FR-180204_3 pi3k / rtk / erk_mapk 1_26457907_T_G / 11_120298301_A_C
188 HOXD10_1 344_THZ-2-49_3 / 298_OSI-930_2 / 310_YM201636_3 cell_cyc / rtk / other 1_26457907_T_G
189 ITFG2_1 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 rtk / pi3k / pi3k 1_26457907_T_G
190 EGFL7_1 263_FR-180204_3 / 271_VNLG/124_3 / 185_Linsitinib_2 erk_mapk / chromatin / igfr 22_22643666_C_G
191 PPP2R2A_5 310_YM201636_3 / 263_FR-180204_3 / 326_GSK690693_3 other / erk_mapk / pi3k 13_20189082_A_C / 12_52771095_C_G / 1_26457907_T_G / 3_126068075_T_G / 22_21127217_C_G
192 BRF2_2 263_FR-180204_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 erk_mapk / pi3k / mitosis 22_21283300_G_C / 7_37907554_A_G
193 ATP1B2_1 294_MPS-1-IN-1_3 / 310_YM201636_3 / 290_KIN001-260_3 mitosis / other / other 16_3027533_A_G
194 PTGES3_2 281_Alectinib_2 / 273_CUDC-101_2 / 228_AKT_inhibitor_VIII_3 rtk / chromatin / pi3k 1_26457907_T_G / 1_149813302_A_C
195 NR0B1_2 1259_Talazoparib_3 / 344_THZ-2-49_3 / 310_YM201636_3 g_integrity / cell_cyc / other 1_26457907_T_G / 22_21127217_C_G
196 GALNT10_2 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 13_99295007_C_T / 13_99314037_A_G
197 TMEM229A_1 263_FR-180204_3 / 1011_Navitoclax_2 / 310_YM201636_3 erk_mapk / apop / other 22_22643666_C_G
198 NCEH1_1 263_FR-180204_3 / 185_Linsitinib_2 / 228_AKT_inhibitor_VIII_3 erk_mapk / igfr / pi3k 6_151015603_C_G
199 C1orf27_1 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 erk_mapk / cell_cyc / other 15_25177023_G_C
200 TMEM14C_1 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 310_YM201636_3 pi3k / erk_mapk / other 6_31662464_C_T
201 DKK3_1 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 erk_mapk / erk_mapk / erk_mapk 11_24729296_G_A
202 LRRC4C_1 263_FR-180204_3 / 344_THZ-2-49_3 / 252_WZ3105_3 erk_mapk / cell_cyc / other 12_52771095_C_G
203 HOXD9_1 263_FR-180204_3 / 344_THZ-2-49_3 / 136_Mitomycin-C_1 erk_mapk / cell_cyc / DNArep 5_140829601_T_G
204 SLC5A6_2 263_FR-180204_3 / 221_TAK-715_2 / 228_AKT_inhibitor_VIII_3 erk_mapk / jnk_p38 / pi3k 1_184808038_A_C / X_46860063_C_T
205 LYPD1_1 274_Belinostat_1 / 273_CUDC-101_2 / 276_CAY10603_3 chromatin / chromatin / chromatin 1_129285_G_A
206 CIB1_1 263_FR-180204_3 / 226_GSK1070916_2 / 305_TPCA-1_3 erk_mapk / mitosis / other 15_25177023_G_C
207 PDSS1_2 263_FR-180204_3 / 1008_Methotrexate_1 / 288_WHI-P97_3 erk_mapk / DNArep / other 15_89633846_A_C / 22_39376109_T_G
208 SHC2_1 326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 pi3k / erk_mapk / other 19_54631904_A_C
209 ATP6V0B_1 1060_PD0325901_2 / 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk / erk_mapk 1_9850602_T_G
210 SEPSECS_1 341_Selisistat_3 / 286_KIN001-236_3 / 1008_Methotrexate_1 other / other / DNArep 2_28529292_G_T
211 BHLHE22_2 310_YM201636_3 / 263_FR-180204_3 other / erk_mapk 1_26457907_T_G / 22_21127217_C_G
212 FOXC1_1 263_FR-180204_3 / 310_YM201636_3 erk_mapk / other 1_26457907_T_G
213 DMRTA1_1 290_KIN001-260_3 / 286_KIN001-236_3 other / other 7_72949311_A_C
214 CRYBG3_2 263_FR-180204_3 / 294_MPS-1-IN-1_3 erk_mapk / mitosis 22_21127217_C_G / 1_149813302_A_C
215 ANKRD28_1 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / pi3k 1_26457907_T_G
216 ZNF467_3 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 17_78120770_A_C / 22_21283300_G_C / 5_157491842_C_T
217 MCU_1 281_Alectinib_2 / 344_THZ-2-49_3 rtk / cell_cyc 1_26457907_T_G
218 ALG6_1 281_Alectinib_2 / 294_MPS-1-IN-1_3 rtk / mitosis 1_26457907_T_G
219 DST_1 263_FR-180204_3 / 185_Linsitinib_2 erk_mapk / igfr 22_22643666_C_G
220 CNOT6_1 263_FR-180204_3 / 294_MPS-1-IN-1_3 erk_mapk / mitosis 22_22643666_C_G
221 SLC25A46_1 283_Omipalisib_2 / 228_AKT_inhibitor_VIII_3 pi3k / pi3k 22_22643666_C_G
222 STRBP_3 263_FR-180204_3 / 1259_Talazoparib_3 erk_mapk / g_integrity 22_22643666_C_G / 16_55810697_G_T / 22_21127217_C_G
223 SLFN11_1 263_FR-180204_3 / 344_THZ-2-49_3 erk_mapk / cell_cyc 15_25177023_G_C
224 IL1R1_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 11_66624536_A_C
225 PDE9A_2 271_VNLG/124_3 / 263_FR-180204_3 chromatin / erk_mapk 19_5654163_A_C / 22_19918884_A_C
226 TXNDC11_1 1011_Navitoclax_2 / 344_THZ-2-49_3 apop / cell_cyc 19_624780_A_G
227 NRP1_2 1526_Refametinib_3 / 1014_Refametinib_2 erk_mapk / erk_mapk 3_180647255_T_TA / 15_68718780_C_T
228 QSER1_1 344_THZ-2-49_3 / 310_YM201636_3 cell_cyc / other 6_31464043_C_T
229 TNIP1_1 1526_Refametinib_3 / 154_CHIR-99021_3 erk_mapk / wnt 3_180647255_T_TA
230 LIMS1_1 1372_Trametinib_1 / 1526_Refametinib_3 erk_mapk / erk_mapk 8_138630731_T_C
231 PNISR_1 265_Tubastatin A_3 / 292_Masitinib_1 chromatin / rtk 15_42142087_A_C
232 MOAP1_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 20_53576113_T_G
233 KAT2B_3 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 pi3k / mitosis 19_17618978_T_G / 19_17618863_T_TG / 22_22643666_C_G
234 NBAS_2 292_Masitinib_1 / 286_KIN001-236_3 rtk / other 1_182843301_T_G / 2_112783793_A_C
235 RPAP3_1 281_Alectinib_2 / 310_YM201636_3 rtk / other 16_3027533_A_G
236 PCDH8_1 263_FR-180204_3 / 310_YM201636_3 erk_mapk / other 12_52771095_C_G
237 NRTN_1 185_Linsitinib_2 / 294_MPS-1-IN-1_3 igfr / mitosis 1_149813302_A_C
238 NFE2L3_3 1242_(5Z)-7-Oxozeaenol_3 / 1014_Refametinib_2 other / erk_mapk 22_32394994_C_G / X_119791251_A_C / 5_113434330_T_G
239 AXL_2 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 4_42616004_T_TA / 4_42616121_A_G
240 FAM84B_1 263_FR-180204_3 / 344_THZ-2-49_3 erk_mapk / cell_cyc 13_24951498_G_C
241 SERPING1_2 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 erk_mapk / pi3k 19_4930892_T_G / 1_151048750_A_C
242 MAN2A2_1 294_MPS-1-IN-1_3 / 263_FR-180204_3 mitosis / erk_mapk 18_112338_G_A
243 PPP1R1B_2 1015_CI-1040_2 / 1062_Selumetinib_2 erk_mapk / erk_mapk 6_53899709_T_G / 7_99012221_A_C
244 LIM2_1 211_TL-2-105_3 / 345_KIN001-270_3 erk_mapk / cell_cyc 1_193249713_C_G
245 ENC1_1 1526_Refametinib_3 / 1372_Trametinib_1 erk_mapk / erk_mapk 15_69422319_A_C
246 TXNDC15_1 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 rtk / pi3k 12_121016539_T_A
247 CTGF_1 1372_Trametinib_1 / 1498_Selumetinib_2 erk_mapk / erk_mapk 10_99533046_A_G
248 EGFLAM_2 281_Alectinib_2 / 252_WZ3105_3 rtk / other 2_217818534_A_G / 2_217817751_A_G
249 ARHGAP10_2 263_FR-180204_3 erk_mapk 22_22643666_C_G / 1_26457907_T_G
250 EBF3_1 344_THZ-2-49_3 cell_cyc 1_26457907_T_G
251 PLAGL2_1 263_FR-180204_3 erk_mapk 1_26457907_T_G
252 XKR4_3 263_FR-180204_3 erk_mapk 1_26457907_T_G / 12_52771095_C_G / 22_21127217_C_G
253 HR_1 288_WHI-P97_3 other 1_26457907_T_G
254 GLB1L2_1 263_FR-180204_3 erk_mapk 22_22643666_C_G
255 GOLIM4_1 263_FR-180204_3 erk_mapk 22_22643666_C_G
256 TMEM127_1 263_FR-180204_3 erk_mapk 22_22643666_C_G
257 USP21_1 263_FR-180204_3 erk_mapk 22_22643666_C_G
258 FAIM_5 344_THZ-2-49_3 cell_cyc 5_141432375_A_C / 1_26457907_T_G / 17_49252681_A_C / 10_122983276_G_A / 15_84654249_A_C
259 COX19_2 326_GSK690693_3 pi3k 22_24658344_C_G / 1_26457907_T_G
260 LRP10_3 344_THZ-2-49_3 cell_cyc 1_26457907_T_G / 12_52771095_C_G / 22_22643666_C_G
261 ASPH_1 1526_Refametinib_3 erk_mapk 3_180647255_T_TA
262 CASP4_1 1526_Refametinib_3 erk_mapk 3_180647255_T_TA
263 PPFIBP1_1 1526_Refametinib_3 erk_mapk 3_180647255_T_TA
264 PRRX2_1 1526_Refametinib_3 erk_mapk 3_180647255_T_TA
265 TADA1_1 1526_Refametinib_3 erk_mapk 3_180647255_T_TA
266 FBXO15_2 288_WHI-P97_3 other 22_22643666_C_G / 22_21127217_C_G
267 RPRD1A_3 263_FR-180204_3 erk_mapk 15_23364657_T_G / 4_190079171_C_T / 15_64381446_G_A
268 HS3ST3B1_2 273_CUDC-101_2 chromatin 15_42142087_A_C / 5_141432375_A_C
269 RBM39_1 286_KIN001-236_3 other 1_26457907_T_G
270 MRPS34_1 1014_Refametinib_2 erk_mapk 3_180647255_T_TA
271 PPARD_1 263_FR-180204_3 erk_mapk 15_25177023_G_C
272 TRIM29_2 1142_HG-5-113-01_2 abl 12_94248247_C_T / 15_50747694_T_C
273 SLITRK3_2 310_YM201636_3 other 12_52771095_C_G / 1_26457907_T_G
274 AOX1_1 185_Linsitinib_2 igfr 6_151015603_C_G
275 WDR41_1 281_Alectinib_2 rtk 2_217818534_A_G
276 WDR60_1 283_Omipalisib_2 pi3k 1_26457907_T_G
277 ELOVL1_1 136_Mitomycin-C_1 DNArep 22_24252424_G_C
278 ISYNA1_1 263_FR-180204_3 erk_mapk 8_22080213_T_C
279 BTBD17_1 281_Alectinib_2 rtk 1_26457907_T_G
280 E2F6_1 281_Alectinib_2 rtk 1_26457907_T_G
281 REEP5_1 281_Alectinib_2 rtk 1_26457907_T_G
282 HIF3A_2 228_AKT_inhibitor_VIII_3 pi3k 1_26457907_T_G / 16_3027533_A_G
283 PLIN3_1 1526_Refametinib_3 erk_mapk 10_92024747_C_T
284 SLC25A43_1 1526_Refametinib_3 erk_mapk 10_92024747_C_T
285 NINL_2 185_Linsitinib_2 igfr 22_22643666_C_G / 1_26457907_T_G
286 ZNF232_2 281_Alectinib_2 rtk 5_141432375_A_C / 6_32040790_G_C
287 SIRT4_5 226_GSK1070916_2 mitosis 19_32862451_C_T / 19_32864163_A_G / 1_26457907_T_G / 15_89806436_T_G / 11_120298301_A_C
288 TP53BP2_1 228_AKT_inhibitor_VIII_3 pi3k 22_21127217_C_G
289 DLGAP1_1 263_FR-180204_3 erk_mapk 22_21127217_C_G
290 ELL2_1 228_AKT_inhibitor_VIII_3 pi3k 22_22643666_C_G
291 L3MBTL1_1 300_CX-5461_3 other 8_22080213_T_C
292 VCL_1 281_Alectinib_2 rtk 5_141432375_A_C
293 FOXN4_1 211_TL-2-105_3 erk_mapk 19_12391643_A_G
294 DGKD_2 288_WHI-P97_3 other 22_24252424_G_C / 11_62825464_G_C
295 UHMK1_2 344_THZ-2-49_3 cell_cyc 6_31710251_C_T / 6_31464043_C_T
296 ATG10_1 1091_BMS-536924_3 igfr 3_120173274_C_G
297 RTN4_1 1526_Refametinib_3 erk_mapk 2_87800520_G_A
298 ZBTB34_2 1091_BMS-536924_3 igfr 11_1244522_A_C / 6_151015603_C_G
299 TRAPPC1_1 1011_Navitoclax_2 apop 16_18896782_A_AAT
300 MAN1A1_1 263_FR-180204_3 erk_mapk 11_61744427_A_C
301 GPR155_1 281_Alectinib_2 rtk 22_22643666_C_G
302 NUP205_1 226_GSK1070916_2 mitosis 17_7604041_A_C
303 DFNA5_1 1526_Refametinib_3 erk_mapk 11_24729296_G_A
304 ESYT2_1 263_FR-180204_3 erk_mapk 2_119366546_A_G
305 ARRDC5_1 1067_CCT007093_3 other 1_112653574_TA_T
306 WWOX_1 185_Linsitinib_2 igfr 22_21127217_C_G
307 TTC12_1 344_THZ-2-49_3 cell_cyc 11_1246619_A_C
308 PHLDA1_1 263_FR-180204_3 erk_mapk 6_151015603_C_G
309 USP44_2 1526_Refametinib_3 erk_mapk 7_155711220_A_C / 15_69422319_A_C
310 PLTP_1 341_Selisistat_3 other 1_176800222_T_C
311 FOXK2_2 1526_Refametinib_3 erk_mapk 17_57105517_C_T / 17_57110197_C_G
312 ERRFI1_1 1372_Trametinib_1 erk_mapk 17_41820457_A_C
313 NCAPG2_2 1378_Bleomycin(50uM)_1 DNArep 17_40554659_A_G / 6_146599135_C_T
314 GNG12_2 1526_Refametinib_3 erk_mapk 4_42616004_T_TA / 4_42616121_A_G
315 GTF2IRD1_2 185_Linsitinib_2 igfr 13_99295924_C_A / 16_4823959_A_C
316 CDH13_1 1526_Refametinib_3 erk_mapk 8_108228165_T_G
317 USPL1_1 1218_JQ1_3 chromatin 11_117206249_T_G
318 C8orf33_2 226_GSK1070916_2 mitosis 1_152805392_A_G / 1_152805488_G_A
319 LARP4_1 344_THZ-2-49_3 cell_cyc 19_21767500_C_T
320 WISP2_3 291_KIN001-266_3 other 15_34382849_C_T / 15_34382220_G_A / 15_34528441_G_A
321 ACTR3B_1 226_GSK1070916_2 mitosis 19_5680513_A_C
322 CACNA1H_1 1091_BMS-536924_3 igfr 1_26457907_T_G
323 KIT_5 1526_Refametinib_3 erk_mapk 19_55181918_C_T / 19_55185911_C_T / 19_55186384_AG_A / 19_55186398_T_A / 19_55186427_G_C
324 PFKFB4_1 1259_Talazoparib_3 g_integrity 2_48582490_G_T
325 PRKCA_1 226_GSK1070916_2 mitosis 14_39074610_T_TAAG
326 PPIB_1 310_YM201636_3 other 12_31206191_C_T
327 GUK1_1 1239_YK-4-279_3 other 3_184849291_A_T
328 TOMM20_1 263_FR-180204_3 erk_mapk 6_33315732_A_C
329 MCFD2_1 1526_Refametinib_3 erk_mapk 7_102356028_T_G
330 ARL2BP_1 1262_UNC1215_3 other 10_17122761_A_AC
331 DSTN_2 51_Dasatinib_1 abl 16_24750598_A_G / 16_24806184_C_T
육종암(bone) 약물에 대한 바이오 마커의 반응성 검증 결과
No. FRH Var_Exp(pval) Var_Drug(pval) Exp_Drug(pval) Ave_VarDrug(pval) Rank
1 LUC7L_5 1.15E-13 1.91E-09 / 4.67E-09 / 2.52E-08 / 4.96E-08 / 6.43E-08 / 1.09E-07 / 5.42E-07 / 5.69E-07 / 6.37E-07 / 6.61E-07 / 7.24E-07 / 8.41E-07 / 9.74E-07 / 1.12E-06 / 1.30E-06 / 1.85E-06 / 2.11E-06 / 2.61E-06 / 4.14E-06 / 4.58E-06 / 4.71E-06 / 5.01E-06 / 6.19E-06 / 6.58E-06 / 8.57E-06 / 1.05E-05 / 1.13E-05 / 1.15E-05 / 1.30E-05 / 1.46E-05 / 1.53E-05 / 1.53E-05 / 1.59E-05 / 1.84E-05 / 2.07E-05 / 2.21E-05 / 2.43E-05 / 2.46E-05 / 2.89E-05 / 3.30E-05 / 3.88E-05 / 4.17E-05 / 4.23E-05 / 4.72E-05 / 6.02E-05 / 7.09E-05 / 7.70E-05 / 8.39E-05 / 8.89E-05 / 9.55E-05 / 0.000109598 / 0.000148946 / 0.000152384 / 0.000155038 / 0.000170866 / 0.000172159 / 0.000191632 / 0.000193261 / 0.000195059 / 0.000248358 / 0.000327687 / 0.000332153 / 0.000349439 / 0.000359765 / 0.00043352 / 0.000523494 / 0.000575856 / 0.00059693 / 0.000653659 / 0.000706716 / 0.00085491 / 0.000864851 / 0.001002398 / 0.00117613 / 0.001408554 / 0.001650567 / 0.001984983 / 0.002024319 / 0.00212417 / 0.002216293 / 0.002233734 / 0.002266673 / 0.002284694 / 0.002445929 / 0.002559027 / 0.002603948 / 0.002721712 / 0.002828387 / 0.003047476 / 0.003355885 / 0.004005854 / 0.004439654 / 0.004491468 / 0.004552462 / 0.005010534 / 0.00514149 / 0.005153885 / 0.005246181 / 0.005770832 / 0.005771327 / 0.006149164 / 0.00699638 / 0.007479033 / 0.009163032 / 0.009744318 9.24E-10 / 7.33E-07 / 1.80E-06 / 5.58E-07 / 5.49E-06 / 8.00E-06 / 1.11E-05 / 3.59E-05 / 2.57E-05 / 1.51E-05 / 0.000278643 / 1.29E-05 / 4.04E-05 / 4.27E-07 / 6.04E-05 / 1.36E-05 / 0.00095004 / 0.000354468 / 7.37E-05 / 0.000178107 / 1.81E-05 / 9.92E-06 / 2.90E-05 / 7.60E-05 / 0.000108534 / 5.28E-06 / 0.000909895 / 0.0001216 / 3.90E-05 / 8.71E-05 / 0.000177412 / 0.000229785 / 0.000206397 / 0.001303165 / 0.000336718 / 0.000220325 / 0.000794135 / 0.005242396 / 0.000138311 / 0.00012461 / 0.002555093 / 3.34E-05 / 0.000212185 / 0.000235135 / 0.003059306 / 0.002031234 / 4.10E-05 / 0.002839464 / 0.001941941 / 0.002111014 / 0.003734935 / 0.00088133 / 0.000260418 / 0.000159567 / 0.000217979 / 0.003045665 / 0.000711377 / 0.004950231 / 0.000568103 / 0.003370008 / 0.000210216 / 0.001266072 / 0.000968439 / 0.00032227 / 0.0047926 / 0.000154025 / 0.000752605 / 0.00142213 / 0.001031722 / 0.001286562 / 0.002164935 / 0.0003112 / 0.002677139 / 0.018218112 / 0.002277549 / 0.109175833 / 0.016662693 / 0.019365546 / 0.002033578 / 0.003027991 / 0.006961933 / 0.025514886 / 0.024966968 / 0.005997059 / 0.001981323 / 0.029427464 / 0.012944297 / 0.01786683 / 0.037151491 / 0.001073091 / 0.000598838 / 0.061847574 / 0.007922021 / 0.022872712 / 0.059848402 / 0.01228946 / 0.01332271 / 0.002004364 / 0.02173673 / 0.012503551 / 0.025681208 / 0.001105028 / 0.008624497 / 0.010968462 / 0.004721309 1.32E-03 105
2 FZD3_1 0.0000000028 2.0071481202007584e-05 / 1.3062838211579366e-05 / 0.00029640089162746337 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 4.559947241482223e-05 / 0.0003167991900078877 / 0.005510243055764825 / 2.4023375765700413e-05 / 0.0019333915490623197 / 3.2501044823812903e-07 / 5.2109649171464235e-06 / 0.0005120167928359619 / 0.0005120167928359619 / 5.1570472200670454e-05 / 5.2109649171464235e-06 / 0.0006200425273220967 / 1.615375160694009e-05 / 0.002238680629992204 / 0.0004073113752386311 / 0.004583801528895219 / 3.1219185299958266e-05 / 0.0002809149065890676 / 0.00043137964232097263 / 0.0011323441860117745 / 0.0005820808941317769 / 0.0004771627200779347 / 0.001077781567228248 / 0.005510243055764825 / 4.0242980256377906e-05 / 0.0014854545690578267 / 5.831891151164244e-05 / 0.001178242777327155 / 8.058554843717415e-06 / 6.979794879972793e-06 / 0.03195616924078522 / 3.54688199707126e-05 / 0.0004422271229621968 / 0.016412811603890378 / 9.224071980226081e-07 / 0.003763661611010697 / 0.005510243055764825 / 0.0019333915490623197 4.399804084045925e-11 / 4.8538578704375377e-11 / 5.819712693031694e-10 / 2.963122656898289e-09 / 4.44134906876112e-09 / 1.7977709248154422e-08 / 9.42533011316618e-09 / 1.1148075349332164e-08 / 9.89017118210351e-09 / 2.8769458288469503e-08 / 8.244633671431711e-10 / 5.45137061905865e-09 / 1.8398488800553676e-08 / 1.804720713536623e-08 / 3.173412287913158e-08 / 9.525086920943969e-09 / 8.7889354451487e-09 / 4.116637231593234e-09 / 2.9588878898633333e-08 / 4.0650948961653235e-08 / 2.8027611743995904e-07 / 6.8134604562299e-07 / 2.1399314856199655e-07 / 5.167422923449075e-08 / 5.613208935352902e-08 / 7.672478617521056e-07 / 1.6315736932712637e-07 / 2.4166361947108844e-07 / 1.451917420035471e-08 / 7.300226960704237e-07 / 1.5352094129494146e-07 / 1.2282012910353222e-06 / 3.875740564606093e-08 / 1.0494748900823875e-07 / 6.763565198781288e-08 / 5.748334030450384e-07 / 3.353627284114995e-06 / 4.936480143362891e-06 / 2.623117317143412e-06 / 5.626937405898294e-07 / 4.3859213486095075e-05 / 5.694315703855324e-08 / 1.2859395153980585e-05 / 5.4888376565657605e-06 / 2.7878746100826557e-05 0.001989712 45
3 LMBR1L_3 0.0000000000 1.3115991775009544e-05 / 4.285325077077582e-05 / 2.6206760013115565e-05 / 8.940710288311502e-06 / 0.00023367518351846944 / 0.00013454362830845267 / 2.7344476741525248e-06 / 0.00015924703665692674 / 5.3436977682081055e-06 / 0.001425251066430146 / 7.290937080786633e-06 / 0.00014505690669972785 / 0.002708575118877282 / 0.0005354820201602493 / 0.0001891558085520366 / 0.0003390052340801507 / 0.00018791070326594343 / 5.476715755935002e-05 / 0.0006679513440066498 / 0.00027536436395942185 / 0.0007522453642716858 / 0.0004227612426053383 / 0.0006897961607062659 / 0.004578099476046143 / 9.144525988487157e-05 / 0.0002954537200985898 / 0.0003409317530540561 / 0.00022273590395933135 / 9.752428481242424e-05 / 2.7031767322445152e-06 / 0.0025088064616324564 / 0.0017094647117891196 / 0.0002960302092991554 / 0.001425251066430146 2.4878867617785033e-08 / 5.567969153038763e-09 / 2.2333257462478582e-06 / 1.5621435413932192e-07 / 8.122287757832368e-07 / 1.1594398210650143e-07 / 2.9535242848860537e-07 / 2.5457580110872606e-07 / 1.1054851619419285e-06 / 3.6946271417190457e-06 / 7.434545034394883e-08 / 4.865301638318462e-07 / 7.955105981028123e-06 / 1.7636078112442492e-06 / 3.8772692803359075e-06 / 4.71942956895538e-06 / 7.710653232292368e-07 / 9.824959916701546e-06 / 2.626863984658229e-06 / 1.4275291126372483e-06 / 5.610135612369372e-06 / 1.985624144436174e-06 / 5.224149339178947e-06 / 1.1780186697477374e-05 / 9.265182617395918e-07 / 7.64885082423866e-07 / 2.3462097383522345e-06 / 7.599816951433106e-06 / 9.768824284806429e-06 / 1.3141060307652716e-05 / 3.191552185410624e-05 / 8.929464106552106e-06 / 2.387431583758606e-06 / 9.679020756011901e-06 0.000605756 34
4 ACTN2_3 0.0000000000 1.6547061876174137e-09 / 7.813308929582946e-09 / 1.3841014381780992e-08 / 7.203525855071736e-08 / 1.8450442549499973e-07 / 3.911794473620475e-08 / 1.4114679221229936e-07 / 0.00012290638155137984 / 3.925563562928499e-06 / 7.3416069286602765e-06 / 3.606677790993339e-06 / 1.4592559377242048e-06 / 3.2260283767681983e-07 / 1.193290985948489e-06 / 3.129728827401602e-07 / 5.1156576790479636e-06 / 2.2015209230331294e-05 / 9.735933136603846e-06 / 3.163985594214517e-06 / 3.935050666499894e-05 / 1.4266019809199946e-07 / 1.545453068208723e-06 / 4.094608902301485e-06 / 6.287076933306607e-05 / 8.143883852558403e-05 / 1.7745606348891978e-05 / 1.9064246508411654e-05 / 3.914526751739124e-06 / 0.0008320152992610897 / 0.00014766547542325887 / 1.0608918025365037e-05 / 1.3327004931767278e-05 / 3.456388577880954e-06 8.346739914919394e-10 / 2.6568139110468435e-10 / 1.4297929266679253e-08 / 1.407569556254511e-08 / 7.425827856215124e-09 / 6.044864807461728e-07 / 4.09575569135761e-08 / 2.5796549872310057e-06 / 9.727443509821518e-06 / 2.0346517301279246e-06 / 1.821337487108634e-07 / 1.1858667937809359e-06 / 3.0908955186716785e-06 / 3.9399829491464125e-06 / 7.557297698538621e-07 / 1.0224109644328716e-05 / 9.68241332215864e-06 / 5.610135612369372e-06 / 7.333671574889317e-06 / 1.6079955555468178e-06 / 1.0121247355306893e-06 / 4.744377470169944e-06 / 4.290604050280735e-06 / 4.1558712164911445e-06 / 4.452894368538964e-06 / 3.298618443622974e-05 / 5.383699135825628e-06 / 5.133532807266582e-06 / 7.79534870420108e-06 / 8.49542319812634e-06 / 7.898719458534555e-06 / 4.382658462880079e-06 / 1.2453763214764084e-05 4.29939E-05 33
5 UBXN7_2 0.0000000085 1.2294933823319138e-07 / 0.0009528394445576896 / 2.5977106349140097e-07 / 4.438966867654239e-06 / 4.175847453807821e-05 / 2.2989177020843574e-05 / 1.0258657437467221e-05 / 6.35563211244946e-07 / 9.34271970438383e-06 / 0.00012842370411037036 / 0.00038022299535494034 / 4.732975057010584e-06 / 6.0398819534333666e-05 / 0.0008312382650131915 / 7.10198962884777e-05 / 0.000737382769650959 / 0.00010754182303257409 / 0.0008657599149476789 / 2.064971477980467e-05 / 0.0021438374376241726 / 0.00011799868875755327 / 6.713449614052975e-05 / 9.23837432003526e-05 / 0.006927717611275514 / 9.323186511449603e-05 / 6.344424772676006e-05 / 7.202281209470204e-05 / 0.0016679197649297247 / 0.0007630126686111583 / 0.00014077366120352972 / 0.0011908689867155006 / 0.00014493182389933843 / 5.074180415291073e-06 1.3148237968215948e-08 / 1.0058181189300685e-08 / 2.866158880903668e-07 / 3.321317019211789e-07 / 2.534746351463287e-07 / 6.649001393280087e-07 / 2.0062892730841753e-06 / 3.0760538337201583e-07 / 1.0537432811773585e-06 / 8.286284914667759e-07 / 2.5056723004222252e-05 / 1.1607897314120808e-06 / 3.6896905862079686e-06 / 2.3529977016400513e-05 / 4.07908271138199e-05 / 2.233895897066247e-05 / 3.9901071706105935e-06 / 9.246191514674586e-06 / 2.970908809716153e-05 / 1.3864656266823086e-05 / 2.7158231870787934e-06 / 2.8767737648395844e-06 / 0.00018285226698360374 / 3.2329494806633123e-06 / 4.56486535636156e-06 / 4.367493381976092e-06 / 2.3915904995124888e-05 / 4.7400303970179404e-05 / 5.693865725616807e-06 / 1.5212355293442166e-06 / 1.4981327208193748e-05 / 1.901917225424515e-05 / 9.246191514674586e-06 0.000537587 33
6 TRAM2_2 0.0000000000 3.4192931304829014e-06 / 1.3401582342156554e-08 / 4.659755401849588e-08 / 3.633081984870721e-07 / 5.207246052888057e-07 / 1.892412103400743e-05 / 1.3942380334535833e-06 / 2.0535846739106096e-05 / 7.359704703027111e-07 / 2.225580423517811e-06 / 5.5806145526532266e-05 / 4.592877446409494e-06 / 4.592877446409494e-06 / 1.8937125547570738e-05 / 0.00021267966425080588 / 0.00095500393558891 / 1.6992771909182382e-05 / 5.326859676055172e-06 / 0.00020111609082546164 / 5.84826493375201e-05 / 1.096889887353167e-06 / 4.05395891219117e-07 / 4.835640776889601e-06 / 1.017482106342708e-05 / 0.00036820277558262876 / 2.3498756278510995e-06 / 6.031057779485052e-06 / 4.602166722353917e-05 / 4.77141612260032e-05 / 7.647399823593637e-05 / 1.3010063548672435e-05 / 5.700938644514364e-06 4.322589807838839e-10 / 1.0710488778074884e-09 / 2.2541585510298175e-09 / 1.567254897199143e-09 / 5.8397941769315956e-08 / 1.0411408006909947e-07 / 1.5621435413932192e-07 / 2.6273639848288776e-07 / 7.180942105428594e-08 / 2.841652507631913e-07 / 1.75722450249221e-07 / 5.273247808971176e-07 / 2.5292802828220107e-07 / 3.6227709430270065e-07 / 3.9578672189598e-07 / 7.272069346106795e-06 / 3.1693546387669756e-07 / 8.122287757832368e-07 / 6.365489980748545e-07 / 7.244824414060728e-07 / 5.5398839416627e-07 / 2.1048201026388255e-08 / 4.694603023798112e-06 / 1.2067933247814594e-06 / 1.9510165024642392e-06 / 1.228062366600316e-06 / 3.739290293217579e-07 / 2.595574803350586e-06 / 7.308783057822739e-06 / 3.561518617190357e-08 / 4.694603023798112e-06 / 1.9523949703929863e-06 6.76165E-05 32
7 CDK13_2 0.0000000046 1.3853996990825065e-07 / 5.7745918340825286e-08 / 1.047470062062923e-07 / 3.956087072154918e-06 / 4.7520049447710837e-07 / 8.531496260442106e-08 / 7.3804316374052654e-06 / 4.47869272440367e-06 / 1.3463919058643852e-06 / 1.280613569121123e-06 / 3.6878940499153197e-07 / 0.00016082587811719362 / 0.00011322141355414124 / 0.0008207792485387008 / 0.0012079337533688077 / 2.9520572987073497e-05 / 1.140318186185745e-06 / 7.232001821345798e-06 / 8.539102875978968e-07 / 4.4499857317195853e-07 / 1.6907634798991045e-06 / 1.436764278578512e-05 / 3.9201554157572025e-06 / 0.00015124776392064736 / 8.137865842046858e-07 / 8.776477751355082e-06 / 7.3804316374052654e-06 / 2.5501614319254746e-05 / 6.930572497830363e-05 / 9.349083309404483e-05 / 3.4999466370498394e-05 / 8.383566724982507e-05 8.041496040856773e-10 / 1.1212152252396135e-09 / 2.2149509398591615e-09 / 6.49921859944133e-08 / 1.146609360749861e-08 / 9.315547292848514e-09 / 7.076208121664563e-08 / 1.5105555334027616e-07 / 1.4275728512486712e-07 / 3.3998096773618356e-07 / 1.7384894474420941e-07 / 1.7501056125582978e-07 / 1.6481167858879217e-07 / 7.741434363358432e-07 / 1.5033075637026901e-06 / 2.258352385302198e-06 / 1.0175118608827892e-07 / 1.054741547163592e-06 / 7.695013127009913e-07 / 7.954172678849231e-07 / 1.1584887732120262e-06 / 1.8682249268554782e-07 / 4.110133905921353e-07 / 2.4667255985252546e-05 / 5.724946196061661e-07 / 4.748434316553696e-06 / 6.535278991184282e-07 / 1.477642900652424e-06 / 3.526294982097946e-06 / 5.176376148472376e-07 / 2.387431583758606e-06 / 2.412245892896333e-05 8.92798E-05 32
8 BCL11B_3 0.0000000011 2.1691780926743226e-07 / 8.225833660011401e-07 / 1.789237622088428e-06 / 2.0356690840892754e-08 / 3.987613565444208e-05 / 9.360516011381817e-06 / 8.9395947547362e-05 / 3.466378757720392e-06 / 1.2385647799184097e-05 / 3.6259855060459035e-05 / 0.00028446811679125046 / 4.3322170131610347e-07 / 3.6694829495818446e-05 / 1.3319185354685384e-05 / 0.0001450120364959482 / 0.0012382643384124116 / 0.00011198347385438923 / 1.2225430006781737e-05 / 2.2121210908325923e-06 / 0.004134037425943515 / 6.357933416947185e-05 / 0.0001845346362830905 / 1.1156277709036697e-05 / 0.0012012138503791107 / 0.0009113487575262121 / 0.00038512818063312726 / 0.00330460988510783 / 0.0011551309927923857 / 0.004248586177433409 / 8.696575941061198e-06 / 0.00035640811201797775 1.4826443090493311e-08 / 2.2740294469952764e-08 / 6.336269186082428e-09 / 3.539172375371934e-08 / 4.7609504610906553e-08 / 1.7960393747350935e-07 / 4.4916588042332195e-07 / 4.870463435270994e-07 / 2.0751734487343673e-08 / 8.867180726585433e-08 / 2.613509065423129e-07 / 4.2998193211784016e-08 / 2.9189015908569146e-07 / 7.796320698489975e-07 / 3.287953600510885e-07 / 4.184506818533476e-07 / 3.425164804138365e-07 / 2.6927928108537883e-07 / 1.5690808649462252e-07 / 6.082660419881746e-06 / 1.3924361879300207e-06 / 1.895443350505234e-06 / 2.370093060682893e-06 / 3.622834973607711e-06 / 3.7283263548613296e-06 / 6.922058937247929e-06 / 2.3405099437428686e-05 / 0.00010413370355979186 / 1.2402625610892681e-05 / 3.912517662348535e-06 / 9.101375208598654e-06 0.00058073 31
9 LONRF1_4 0.0000000000 2.3042263304124516e-06 / 8.182623816859019e-08 / 7.449035561194172e-08 / 3.271165707863933e-07 / 3.872601102158526e-06 / 8.238465335223179e-05 / 1.020006295103392e-05 / 4.780055898330748e-05 / 6.0132262668712315e-05 / 0.00025833801594167625 / 4.823369084488708e-05 / 9.377014819070716e-08 / 1.8750944559946824e-05 / 0.0002257748867625031 / 4.61034011703085e-05 / 6.434547053133198e-06 / 0.0024160298697904117 / 6.16484303738615e-05 / 6.232941894500062e-06 / 8.832466534601092e-05 / 0.00014573543615757138 / 2.1793939320273974e-05 / 3.088478798821713e-05 / 5.3959564521511103e-05 / 8.545068477488772e-05 / 0.0010681118057163815 / 0.0006404527227598945 / 0.0010528904729959797 / 4.7004221317801894e-05 2.871690193004347e-09 / 7.780203727430123e-11 / 1.1090993827240565e-09 / 4.885836011088783e-09 / 4.3845626278981783e-08 / 3.800967952270995e-08 / 6.548683737212715e-07 / 9.934081050522841e-07 / 1.2258836498170386e-07 / 4.412782355372596e-07 / 9.84639797132252e-07 / 1.0962753584080669e-07 / 2.504876298772149e-06 / 4.981808633338559e-06 / 9.170385978844389e-07 / 3.2430481749669908e-06 / 5.197036451631831e-06 / 2.542113471225459e-06 / 2.116056737675851e-06 / 1.1892345151796726e-06 / 3.74526002970195e-05 / 3.3592564682108814e-06 / 6.814920333363255e-06 / 3.2430481749669908e-06 / 6.4967649552906986e-06 / 4.180561542903392e-05 / 3.3264582250052445e-05 / 8.095222217568488e-06 / 6.77844689688323e-05 0.000225153 29
10 NUDT16_1 0.0000003288 2.7109747094287326e-07 / 5.2109649171464235e-06 / 9.224071980226081e-07 / 0.0004422271229621968 / 1.3062838211579366e-05 / 0.004583801528895219 / 0.0004771627200779347 / 3.2501044823812903e-07 / 5.2109649171464235e-06 / 0.0014854545690578267 / 6.979794879972793e-06 / 0.0019333915490623197 / 0.00043137964232097263 / 4.0242980256377906e-05 / 0.001077781567228248 / 3.54688199707126e-05 / 2.0071481202007584e-05 / 5.831891151164244e-05 / 0.0005120167928359619 / 4.559947241482223e-05 / 9.289397717877934e-06 / 0.0004073113752386311 / 0.017443989828652796 / 0.00025640470531776904 / 2.408755304649635e-05 / 3.1219185299958266e-05 / 5.1570472200670454e-05 / 1.615375160694009e-05 / 3.54688199707126e-05 5.385967484932456e-09 / 1.0900516853889578e-07 / 4.2678416681249765e-07 / 6.789788444310893e-08 / 5.701290417865207e-06 / 9.053292911304865e-07 / 8.186772624145206e-09 / 6.986597395696305e-07 / 9.299566826975888e-06 / 1.284325373822431e-07 / 3.519975525761359e-06 / 3.6551366345535073e-06 / 1.0585574831405579e-05 / 5.818012600528764e-06 / 8.591203793133295e-06 / 9.316488159288118e-07 / 1.764956512450499e-05 / 2.1357679726611226e-06 / 9.093604943452581e-06 / 1.5567150556965707e-05 / 3.245778635071659e-06 / 6.404889387734338e-06 / 4.079221141533871e-05 / 9.199981706216294e-06 / 4.3364053194329025e-06 / 2.601132064226823e-05 / 1.533327496967292e-05 / 2.2421339006083023e-05 / 2.984896137178954e-05 0.001015531 29
11 BDKRB1_1 0.0000021162 2.051237402337122e-05 / 0.0002944288613709527 / 1.1263759452799203e-06 / 0.005398390884784092 / 0.00014547367344876742 / 0.0008581803853921776 / 9.971939174478468e-05 / 0.0001395680222164631 / 0.0005345324666238675 / 0.0026702661426604127 / 0.0036790499750236597 / 0.00036105139567184824 / 0.004298857351174951 / 0.0003301911422383287 / 0.006072266622156599 / 0.0028963504457353837 / 0.0008619933402586612 / 0.0014783442733670397 / 0.002082636216901017 / 0.0038265104822853674 / 0.0012393227037226365 / 0.0001249119186090808 / 0.0014783442733670397 / 0.009354429645569597 / 6.267778266652492e-05 / 0.0010353911778693099 / 0.0067509647795811235 / 0.00017366806695686554 7.120406194930282e-10 / 1.3196888168609393e-07 / 9.697204620602088e-09 / 1.088769714704053e-07 / 7.422682196769718e-08 / 6.17052942560377e-06 / 1.3710585742644193e-06 / 3.457696931263268e-08 / 2.6405169262238316e-06 / 1.036277076972443e-06 / 1.460759694934436e-06 / 3.8350091086392213e-07 / 1.266977339256832e-07 / 5.261863247063795e-07 / 1.698316254132078e-07 / 2.8478812173765797e-06 / 3.786868009340554e-07 / 1.8874782131634276e-06 / 5.371804546576567e-07 / 7.75343185764559e-06 / 9.483756578219822e-07 / 2.805248379242514e-07 / 2.019377115873876e-06 / 2.662855068818181e-07 / 2.339150064869274e-07 / 3.069489887698277e-07 / 2.1398422229289988e-05 / 3.835974713623205e-06 0.002009613 28
12 ACVR1B_1 0.0000000083 9.289397717877934e-06 / 2.408755304649635e-05 / 0.0003167991900078877 / 9.224071980226081e-07 / 5.1570472200670454e-05 / 8.058554843717415e-06 / 0.00043137964232097263 / 0.0004771627200779347 / 0.0005120167928359619 / 0.004583801528895219 / 2.0071481202007584e-05 / 0.0014854545690578267 / 0.0019333915490623197 / 1.3062838211579366e-05 / 3.54688199707126e-05 / 0.00299921656722761 / 3.54688199707126e-05 / 0.00029640089162746337 / 0.0004073113752386311 / 4.0242980256377906e-05 / 4.559947241482223e-05 / 0.0004422271229621968 / 5.2109649171464235e-06 / 5.2109649171464235e-06 / 4.0242980256377906e-05 / 0.0005120167928359619 / 3.2501044823812903e-07 1.998372850901874e-09 / 1.0776011928357113e-07 / 5.6474630649123774e-08 / 4.2739967072439055e-08 / 5.763039230727411e-08 / 9.002284340324614e-08 / 7.938422465642845e-08 / 1.2831192229268504e-09 / 7.481479973456353e-07 / 1.5568154753866115e-07 / 1.3255462641590073e-07 / 1.2540923765124735e-08 / 1.1641859357749167e-06 / 6.487275081622067e-07 / 6.067873978076284e-07 / 4.061559955180453e-06 / 3.085926641657104e-07 / 2.1304437118144328e-07 / 1.614987656365666e-06 / 1.6505215509412846e-06 / 1.100046276296759e-07 / 7.257376518723062e-08 / 6.752087125171909e-06 / 5.013481886934968e-07 / 7.94905114529822e-06 / 2.0096587893651723e-06 / 1.4098818268841097e-06 0.00054563 27
13 FUCA2_5 0.0000000000 7.326897656479634e-08 / 6.283050277058581e-07 / 6.33011695404466e-08 / 1.557810894407547e-08 / 1.4405701094138483e-07 / 8.973492705988831e-07 / 1.2247130912164364e-05 / 1.615099681752137e-08 / 1.0657346371809004e-06 / 2.6787796651465993e-05 / 1.9131942692024663e-06 / 1.7122549667747245e-06 / 1.8435980433182962e-05 / 1.6062625517222244e-05 / 2.1026075258297646e-05 / 4.784284498191245e-06 / 5.047975911248677e-07 / 3.7790277202725207e-05 / 0.00027096327284696815 / 4.4448750105807616e-06 / 9.795809542649757e-06 / 1.2637608316913067e-05 / 3.318559639876234e-05 / 0.00019702583169390873 / 0.0001046372470755123 / 1.6587047672491597e-05 2.695852819501535e-08 / 2.244217853888235e-07 / 2.1408641399345624e-09 / 4.459485961371418e-08 / 6.368941796707181e-08 / 1.6401205520911236e-06 / 9.97301936759034e-07 / 1.213349385759083e-08 / 8.60619982006544e-07 / 6.542182298700363e-07 / 2.4706785728123763e-06 / 2.8446904316163366e-07 / 3.1535389731478223e-06 / 4.116049846272149e-06 / 2.7284438670428954e-06 / 1.3028596303113042e-06 / 8.126089203342205e-06 / 1.927097516170564e-06 / 8.31845006069511e-06 / 2.632617725021655e-06 / 3.954576249334482e-06 / 2.2796504010207573e-06 / 2.8025242380326764e-05 / 3.9907455715014176e-05 / 1.0808234857902164e-05 / 1.4622833564552763e-06 3.05171E-05 26
14 ZNF862_2 0.0000000000 5.757970402201313e-07 / 2.4029731505743387e-06 / 3.4338370713294263e-06 / 8.969803817399693e-06 / 3.673072285712733e-05 / 3.335194286983359e-06 / 9.35679667115326e-07 / 2.4638369795534228e-05 / 9.857812985592748e-06 / 4.7662233548054945e-06 / 4.252860467065013e-05 / 9.555888578983361e-05 / 2.9781866792031246e-05 / 0.0001422310318318236 / 2.0739253861638837e-06 / 2.0842424513236034e-05 / 0.0001466471398885516 / 1.960392177885001e-05 / 0.00014017916355145386 / 3.507870077084195e-05 / 2.8463522605801884e-06 / 9.490939642100406e-06 / 2.4179541415210912e-05 / 4.771691927687007e-05 / 0.0018357138624291076 / 0.0004214818735639107 6.669284403690585e-09 / 1.0986500719843909e-07 / 1.2920530726355395e-08 / 7.144193992690255e-07 / 8.897098518847435e-08 / 2.143448052078468e-07 / 1.1024290553572537e-07 / 1.4570264791055579e-06 / 5.394353982216976e-07 / 1.6497978521887276e-07 / 4.261784119390405e-06 / 3.913300846178839e-06 / 3.851296907021924e-07 / 1.3419887854662606e-06 / 7.36330097877341e-07 / 6.509968171609093e-06 / 6.683327596452262e-07 / 2.3915368068802614e-06 / 6.713901833795875e-06 / 1.1872388449378272e-06 / 1.4047060577114316e-06 / 1.484859827728269e-06 / 2.9956513765454837e-05 / 1.3836812552345798e-05 / 1.8400365047125074e-06 / 2.8632422146042694e-05 0.000119677 26
15 JAKMIP2_1 0.0000003136 1.887107728600381e-05 / 0.00011602560329098725 / 0.0001432193232982916 / 0.0001432193232982916 / 0.0002441254991542676 / 0.006227948945630897 / 0.0003000003635118199 / 0.003136344446815041 / 0.0010434554869778357 / 0.001424661642376461 / 0.0004963923899259765 / 0.00011484315511043709 / 0.0011412468921657625 / 0.00033206653362091303 / 0.0011737393453168934 / 0.00021988598115354305 / 0.00019784908671616698 / 0.00033206653362091303 / 0.0007934067413946306 / 0.0007228851823325908 / 0.0003242200414121999 / 0.0033705319486407362 / 0.0020865035640383737 / 0.004284102869708787 / 0.001710012299865077 1.5055398107137094e-08 / 1.1317898810241505e-07 / 3.014192988473054e-07 / 6.562524735452552e-07 / 1.2620827414204395e-06 / 1.3813768678383736e-05 / 3.0528002185491916e-06 / 4.084105074757677e-06 / 1.2768262591823334e-06 / 8.84661511463528e-05 / 5.301506195235781e-06 / 3.73908096007415e-06 / 2.881552294460198e-07 / 3.7090918031637474e-06 / 8.877144806640423e-06 / 1.0731167574000379e-05 / 4.60217321009711e-06 / 3.1972497431176806e-06 / 7.72630923511333e-06 / 9.788516703431554e-06 / 1.694391766170071e-05 / 1.9122978701285485e-05 / 2.1160442665025628e-05 / 0.00012419843212817223 / 3.665339330112523e-05 0.001203905 25
16 RHBDD2_2 0.0000000381 1.3853996990825065e-07 / 4.7520049447710837e-07 / 3.956087072154918e-06 / 1.280613569121123e-06 / 8.539102875978968e-07 / 2.5501614319254746e-05 / 0.0005420861101080113 / 5.7745918340825286e-08 / 8.776477751355082e-06 / 0.00015124776392064736 / 2.9520572987073497e-05 / 4.47869272440367e-06 / 1.140318186185745e-06 / 7.232001821345798e-06 / 3.9201554157572025e-06 / 4.4499857317195853e-07 / 6.930572497830363e-05 / 1.047470062062923e-07 / 0.00019163973853294472 / 7.3804316374052654e-06 / 3.6878940499153197e-07 / 2.2563184614877053e-05 / 0.0012079337533688077 1.3993846023737915e-07 / 4.7782451098120726e-08 / 1.34825995314718e-07 / 9.277238538824435e-08 / 7.956677787090288e-08 / 1.9225900129783712e-07 / 4.7263934234281247e-07 / 4.706709396786997e-07 / 6.949261184656789e-07 / 7.829247098324768e-06 / 5.071860028688062e-06 / 6.993311385406026e-06 / 1.4497257721405869e-06 / 1.0714836567004093e-06 / 1.4372683450836863e-06 / 4.455852411812759e-07 / 1.815987875798767e-05 / 5.0475687702261924e-05 / 2.8193572587039603e-05 / 1.0465678177194616e-06 / 9.053292911304865e-07 / 7.583935924635759e-06 / 9.83485693819911e-06 9.91481E-05 23
17 NELL2_2 0.0000000034 1.6974372024295342e-05 / 6.21390552863653e-07 / 7.492219023207615e-07 / 0.00033397296479027066 / 6.419532166056714e-06 / 3.680752556412065e-06 / 2.702881264505673e-05 / 0.0001892136695208884 / 0.00013627250802194024 / 4.7592039918640816e-05 / 0.0006954055695635021 / 1.6060512405884523e-05 / 0.00020956984034738803 / 6.893999398193879e-07 / 2.7044709406151057e-06 / 1.030767276264569e-05 / 0.00011664561575068539 / 7.396819433180742e-05 / 0.0033003547134611197 / 0.0007339964856567068 / 3.212738000062656e-05 / 5.509863153367014e-05 / 0.0014134565502491926 1.805210992172401e-08 / 1.036277076972443e-06 / 1.6727928235519174e-05 / 1.3595686728091487e-05 / 3.109078579168171e-07 / 2.9751938937015323e-06 / 3.0194508969201275e-06 / 1.6481167858879217e-07 / 1.0183622735900536e-06 / 2.551343424529328e-06 / 8.778520319265194e-07 / 4.509011181702684e-05 / 3.1588674679295282e-06 / 4.870956378452621e-06 / 4.222740574602922e-06 / 9.393121861778026e-06 / 5.533180942415662e-06 / 2.6252332329450155e-05 / 8.461228664041275e-06 / 2.9713091532112142e-05 / 5.2787519047573424e-05 / 2.9042216064749748e-05 / 4.1781335008242154e-05 0.000322735 23
18 LIPI_3_23 0.0000000000 8.447946079053626e-08 / 1.205208755759072e-06 / 4.854502381230392e-07 / 2.1301603555625764e-05 / 6.853246565784258e-06 / 2.1960012732279454e-05 / 2.6827365804354637e-05 / 1.2548296867935075e-05 / 0.0002009891841455023 / 4.514325991172083e-05 / 6.291115981061851e-05 / 3.312532784218011e-05 / 6.011489855493573e-07 / 0.00014831370330060418 / 1.7445373847640036e-05 / 0.004714448601828642 / 0.0032002760896811776 / 0.0004620869369249564 / 0.0003755600058949459 / 1.2884839156193493e-05 / 0.0011512736162346696 / 0.00013581452355279118 / 0.0009812281151223513 5.468987072460599e-10 / 2.6158726903289238e-08 / 3.565426338432271e-08 / 8.478661382630348e-07 / 3.875609327625631e-07 / 4.840300983601908e-07 / 8.703948887755087e-07 / 9.72132002734069e-07 / 6.098991982334273e-07 / 3.658889330776619e-06 / 1.739637519533283e-05 / 3.2315430831611734e-06 / 8.154288030550316e-08 / 3.3855189139433126e-06 / 1.76044274336364e-06 / 3.077281478322042e-06 / 7.717215517819916e-05 / 3.986852616595454e-05 / 0.0001488041159355547 / 4.81219243302854e-06 / 3.139552211698547e-05 / 2.5976982501110966e-05 / 1.2619626971823594e-05 0.000505799 23
19 RUNX1_1 0.0000001763 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 5.1570472200670454e-05 / 0.005510243055764825 / 0.0019333915490623197 / 2.408755304649635e-05 / 0.0005120167928359619 / 2.7109747094287326e-07 / 1.3062838211579366e-05 / 3.54688199707126e-05 / 0.0006200425273220967 / 0.00029640089162746337 / 5.2109649171464235e-06 / 8.058554843717415e-06 / 5.2109649171464235e-06 / 0.0006813940301036226 / 0.0003167991900078877 / 5.831891151164244e-05 / 0.0017723102864169204 / 6.979794879972793e-06 / 4.491442887170463e-06 1.1641966632063906e-10 / 7.92535031547177e-09 / 5.753632350484074e-09 / 1.0677978948737271e-07 / 3.665113066608255e-07 / 1.4992785773118291e-06 / 1.2569627975426034e-06 / 4.294667785263063e-07 / 2.58629690488761e-06 / 6.186351504175007e-07 / 2.7175791335738627e-06 / 5.643067361003201e-07 / 1.7425168489071174e-06 / 1.244203208123666e-06 / 1.3319999198783528e-06 / 7.864816120590302e-08 / 1.998199593822845e-07 / 3.4658375428977435e-06 / 1.228062366600316e-06 / 1.3596443786771905e-05 / 1.714256584966273e-06 / 4.1558712164911445e-06 / 1.5033075637026901e-06 0.00051678 23
20 UGT3A2_1 0.0000012269 9.224071980226081e-07 / 3.2501044823812903e-07 / 2.408755304649635e-05 / 6.979794879972793e-06 / 0.0003167991900078877 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 2.0071481202007584e-05 / 8.058554843717415e-06 / 0.0004073113752386311 / 4.0242980256377906e-05 / 5.2109649171464235e-06 / 0.0005120167928359619 / 3.54688199707126e-05 / 0.0019333915490623197 / 9.224071980226081e-07 / 0.017443989828652796 / 1.615375160694009e-05 / 5.2109649171464235e-06 / 5.1601659937199475e-05 / 0.00029640089162746337 / 0.0019333915490623197 / 5.1570472200670454e-05 1.381799790744931e-09 / 1.805210992172401e-08 / 9.694448730531385e-08 / 4.403550218821958e-07 / 2.9355105945215545e-08 / 1.045969028083387e-07 / 3.835974713623205e-06 / 2.3222021704967167e-07 / 4.773025688625418e-08 / 9.343660219128231e-07 / 3.6689667424468134e-07 / 2.4140542299703294e-06 / 3.1276785123692046e-07 / 5.018595857384795e-07 / 2.387431583758606e-06 / 1.0035560526801471e-07 / 2.2657213911761568e-05 / 1.0022702721591722e-05 / 9.972925901562962e-06 / 1.8557759701880527e-06 / 1.554298505895915e-06 / 2.5796549872310057e-06 / 4.9185008634943495e-06 0.001005204 23
21 SLAIN1_2 0.0000000001 1.3401582342156554e-08 / 7.359704703027111e-07 / 4.659755401849588e-08 / 0.00012785013168945162 / 3.4192931304829014e-06 / 4.592877446409494e-06 / 5.207246052888057e-07 / 3.633081984870721e-07 / 4.05395891219117e-07 / 4.835640776889601e-06 / 4.602166722353917e-05 / 2.225580423517811e-06 / 5.326859676055172e-06 / 2.0535846739106096e-05 / 1.3942380334535833e-06 / 1.096889887353167e-06 / 4.77141612260032e-05 / 4.592877446409494e-06 / 0.00011487199668000062 / 0.00021267966425080588 7.85839937243628e-09 / 4.2881222404900966e-09 / 4.232043687265545e-08 / 4.48703162941859e-07 / 3.401659596258682e-07 / 5.695617165978249e-07 / 3.159236368559607e-07 / 1.9077743153626155e-07 / 1.305430203445936e-06 / 3.594837020072477e-05 / 1.4937326562948882e-07 / 9.345028580131548e-07 / 2.9676196803014993e-06 / 2.4190454710072306e-06 / 7.316779637097216e-06 / 2.031054374651815e-06 / 4.1261024294080975e-06 / 4.360382079203378e-06 / 1.3128908636239939e-06 / 3.4828848664424397e-06 2.99622E-05 20
22 TRPM4_3 0.0000000003 9.196770242715937e-09 / 2.664719965991362e-08 / 3.725931030072998e-06 / 2.0944901905984007e-05 / 1.347120953229711e-06 / 1.0865942049799405e-07 / 0.00047815490214213265 / 9.236060166459222e-07 / 3.900469077615773e-06 / 8.121356876763278e-06 / 7.49526869739906e-07 / 0.0042689591705948856 / 8.209562763309459e-06 / 1.5485664592082808e-05 / 2.1196123383966528e-05 / 3.5495647595004414e-05 / 3.8020455601505727e-07 / 1.8325658404407734e-05 / 1.9521118173804467e-05 / 3.311124664582957e-06 2.1749725015902454e-10 / 2.0414050703934923e-08 / 3.1693546387669756e-07 / 3.0408081748624807e-06 / 9.653812249086853e-07 / 2.9355105945215545e-08 / 2.00027266182616e-05 / 2.7663883060711165e-06 / 5.405035911800092e-07 / 1.8142742683524817e-06 / 4.794639512641633e-06 / 7.1412649173752545e-06 / 1.0690993559290582e-05 / 4.620846133046724e-06 / 2.5629460029005674e-06 / 1.8751868580077024e-05 / 9.824959916701546e-06 / 6.0957425825213314e-06 / 2.2006142512020074e-05 / 3.4448329577362182e-06 0.000245445 20
23 SLC24A3_1 0.0000000210 1.1263759452799203e-06 / 2.051237402337122e-05 / 9.971939174478468e-05 / 4.369070707050029e-05 / 0.00017366806695686554 / 0.0008581803853921776 / 0.00014547367344876742 / 0.0001395680222164631 / 0.0001249119186090808 / 0.0002944288613709527 / 0.0010353911778693099 / 6.267778266652492e-05 / 0.0006503983018257066 / 0.0012393227037226365 / 7.924407878618111e-05 / 0.0002944288613709527 / 0.0008619933402586612 / 0.0026702661426604127 / 1.7999540459370774e-05 / 0.0031060111248571412 6.407832325684251e-09 / 9.240926568058304e-09 / 9.966453961357818e-08 / 3.08922513577382e-07 / 8.520500454117749e-07 / 7.642146337997833e-07 / 2.5299574218373655e-07 / 7.330469554133431e-08 / 1.6814800128714516e-07 / 6.0957425825213314e-06 / 2.9345983642597263e-07 / 1.0181132930253954e-06 / 3.4215164228215663e-07 / 4.6580022097987207e-07 / 8.830988008417038e-07 / 2.65171239271242e-06 / 2.322060799489299e-06 / 9.727443509821518e-06 / 3.786868009340554e-07 / 1.0862691344015027e-05 0.000595951 20
24 NCKAP1L_1 0.0000001762 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 4.0242980256377906e-05 / 5.2109649171464235e-06 / 0.0004073113752386311 / 0.00029640089162746337 / 0.0003167991900078877 / 5.2109649171464235e-06 / 3.54688199707126e-05 / 0.017443989828652796 / 9.289397717877934e-06 / 5.1601659937199475e-05 / 2.7109747094287326e-07 / 0.0005120167928359619 / 8.058554843717415e-06 / 2.408755304649635e-05 / 0.0019333915490623197 / 1.3062838211579366e-05 7.9904530083348e-11 / 2.4994053567542328e-09 / 9.924736193254942e-08 / 1.8132622674092954e-07 / 1.4200503117731924e-07 / 2.069668183072629e-07 / 1.2682052722257146e-06 / 2.9447437356082395e-07 / 6.313636923660506e-07 / 3.0174324318950897e-07 / 4.4682920249147006e-07 / 1.7578808963170404e-05 / 4.263423766146041e-07 / 7.92201170417271e-07 / 9.008258721422489e-07 / 2.0908224860853314e-06 / 3.056396462394648e-07 / 1.3307689369536397e-06 / 5.981606289641214e-06 / 2.3027940859808657e-06 0.001056536 20
25 RAB32_3 0.0000000000 7.292182530573412e-05 / 0.0003225223870914812 / 2.2327691127733746e-05 / 0.00038393847007829764 / 3.886421476307484e-05 / 0.00013655060364162736 / 0.00024209823898958905 / 1.5637203423692577e-05 / 2.238208719127431e-05 / 0.0002565324608559162 / 1.0853983312684394e-05 / 3.3987574572169257e-06 / 0.003487304520950219 / 0.0014199624577438193 / 0.00016938096923286043 / 0.0003781658379275213 / 0.0039368730296373096 / 0.0023817198498238316 / 0.0021712362602544022 1.0130573619295235e-08 / 5.741020731646927e-08 / 9.202018333928226e-08 / 1.4025070456802076e-07 / 7.718777494211644e-07 / 7.407426548536711e-08 / 1.8556041703527292e-07 / 5.751375891322542e-07 / 9.654719902897998e-07 / 2.0179929179508126e-07 / 2.4077694825580987e-06 / 7.539024856072121e-08 / 1.4948990890785054e-06 / 3.549228834149341e-06 / 2.6963041058083467e-06 / 5.538818081011408e-06 / 9.408104215481871e-06 / 7.311276565893818e-07 / 5.17516813573647e-06 0.000814351 19
26 E2F5_1 0.0000004973 4.335544688590604e-05 / 0.0016610593752756947 / 0.00015165886425239433 / 0.0020037138718268558 / 0.0062926107897605076 / 0.008954836987534829 / 0.0013997024178051241 / 0.0017438515808585928 / 0.005852051539088946 / 0.0013991989944309945 / 0.0037308274054686026 / 0.001807326102912818 / 0.0014458717426393303 / 0.0006825622924508404 / 0.006160732768120326 / 0.008954836987534829 / 0.004687460046810221 / 0.0001360945704417454 / 0.0072609125485500695 2.612437800154611e-10 / 1.5925972264030232e-08 / 3.100531350503503e-08 / 6.448536988230897e-08 / 5.466544241455998e-07 / 3.2169896739895314e-07 / 3.1906789245845806e-06 / 2.3096174786096604e-06 / 1.0141504136839242e-06 / 2.260690937267708e-06 / 9.279972919171246e-07 / 2.847754855927293e-07 / 6.680245031011018e-06 / 5.490090984753377e-06 / 1.077519353313373e-06 / 5.376695975590836e-06 / 4.7530598444137695e-06 / 2.3590259977159812e-06 / 8.340398610953811e-06 0.003387824 19
27 RBM11_5 0.0000000000 1.4526084780295787e-06 / 5.443773486089936e-07 / 1.1971991474232777e-05 / 6.91934628205793e-05 / 2.5796294158785155e-05 / 2.552372456547772e-05 / 1.829615188324561e-05 / 0.00032472688716174674 / 0.001180151638718015 / 4.2244922676709556e-05 / 0.00017279410375636235 / 0.0051673606935049915 / 2.6544638405574182e-05 / 1.4103499755990336e-05 / 0.0008670088401703034 / 0.00038070130611975926 / 0.0007339140203518938 / 0.0002219001663689648 3.3998096773618356e-07 / 1.045969028083387e-07 / 8.800196900298445e-06 / 8.936798924355491e-07 / 2.208556405239799e-06 / 2.223017106257352e-06 / 4.845393516836826e-06 / 2.2421339006083023e-05 / 4.345707282768042e-05 / 1.8399624316894983e-05 / 8.025474759619109e-07 / 0.00010333461220899216 / 3.039816166758595e-05 / 1.0072708544500107e-05 / 1.0221468717522446e-05 / 0.0001719448294932468 / 8.296198213269645e-05 / 2.393187109770829e-05 0.000515791 18
28 JHDM1D_1 0.0000000465 1.887107728600381e-05 / 0.0019194247450850443 / 0.0010434554869778357 / 0.00021988598115354305 / 0.00011602560329098725 / 0.0005437871552770366 / 0.0001432193232982916 / 0.00019784908671616698 / 0.00033206653362091303 / 0.0003000003635118199 / 8.177669445709026e-05 / 0.0019387958818788326 / 0.0020865035640383737 / 0.00019784908671616698 / 0.0003935478447180597 / 0.002087197919276702 / 0.00033206653362091303 5.957947041241642e-10 / 4.7213815560041737e-07 / 1.2953287867816182e-06 / 1.517275876808106e-07 / 2.0848690809316758e-07 / 2.1505701666588e-07 / 7.184717182652482e-08 / 3.4470235709692284e-07 / 6.582103467311211e-07 / 3.4690122473485e-07 / 2.581774969081794e-07 / 2.783019047305537e-07 / 2.2587138448042827e-06 / 3.436077993294023e-07 / 1.3808771629119943e-07 / 1.0777981400774649e-06 / 4.837594802084705e-06 0.000703078 17
29 SDC1_2 0.0000000025 3.24920563754477e-05 / 1.3377106429420062e-05 / 2.286373051099475e-05 / 8.919615355047188e-05 / 0.00015487870247863725 / 0.0003070420132331339 / 6.552854468616073e-05 / 0.010204546359181573 / 0.0004579043420381389 / 0.0003133243150903811 / 1.2750924916385893e-05 / 2.9619864783219557e-05 / 0.00011623700055853398 / 1.6676618048371524e-06 / 0.0002836145894393715 / 0.0014642811488913923 / 3.349324237754571e-06 1.446249458351141e-08 / 1.1593366582600526e-07 / 1.8212505086597223e-07 / 2.805221831770931e-07 / 1.52555181061785e-07 / 1.3421491093673395e-07 / 5.838895464045765e-08 / 8.431612764947411e-07 / 1.4442373350859127e-06 / 2.7186262684030095e-06 / 5.355505538740775e-07 / 1.058510323843106e-06 / 6.635824670736839e-07 / 3.247865406241601e-05 / 4.51316772311888e-06 / 2.621113516811208e-07 / 1.9091723806799227e-06 0.000798393 17
30 ENPP3_2 0.0000000002 7.220251902586713e-08 / 1.5415033312027603e-05 / 2.140496501618477e-08 / 1.0829140297466289e-09 / 4.864296167501907e-07 / 4.1398213999064624e-06 / 1.3483681400210042e-06 / 6.882770012055959e-06 / 5.9617084438303865e-06 / 3.539399887995572e-05 / 1.2072926853768964e-05 / 1.1605014260398891e-06 / 3.934765724180659e-07 / 1.3398427589553948e-05 / 2.132615896596937e-05 / 2.4103457859893014e-05 1.9517835933891448e-08 / 2.248231048691535e-08 / 4.830482337300574e-08 / 1.481967113051988e-07 / 4.175954165049041e-08 / 1.6171122367004618e-07 / 1.6052769492778243e-06 / 4.900800780379338e-07 / 9.924621104960267e-07 / 2.3418243309125566e-06 / 5.843072350429807e-07 / 3.2579388947351196e-06 / 1.1836495389262217e-06 / 1.1411599622062492e-05 / 2.843023304997815e-06 / 1.828727174279431e-05 8.88611E-06 16
31 RBM33_1 0.0000000000 9.289397717877934e-06 / 3.2501044823812903e-07 / 6.979794879972793e-06 / 5.1570472200670454e-05 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 4.491442887170463e-06 / 2.408755304649635e-05 / 5.2109649171464235e-06 / 3.54688199707126e-05 / 3.54688199707126e-05 / 0.0004073113752386311 / 5.1601659937199475e-05 / 0.00043137964232097263 / 4.0242980256377906e-05 / 5.2109649171464235e-06 8.944918223939934e-09 / 9.053698775288811e-09 / 2.5457122572689533e-07 / 1.5628889781375459e-07 / 9.626516148430137e-08 / 4.9661337040464625e-08 / 1.4653913639914694e-07 / 9.345028580131548e-07 / 1.2202889190119188e-07 / 1.2069281833924902e-06 / 3.4985449908631084e-07 / 3.210007225110076e-06 / 3.041361665158829e-06 / 7.856862302531046e-06 / 1.7638568513415927e-06 / 8.270219208624064e-07 6.93645E-05 16
32 MYOM2_1 0.0000000034 3.2501044823812903e-07 / 9.224071980226081e-07 / 1.3062838211579366e-05 / 9.289397717877934e-06 / 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 0.001077781567228248 / 5.2109649171464235e-06 / 3.54688199707126e-05 / 0.0006200425273220967 / 5.1570472200670454e-05 / 3.1219185299958266e-05 / 0.0005820808941317769 / 2.7109747094287326e-07 7.84964801360265e-09 / 1.1586817234891624e-08 / 6.152115559989733e-07 / 1.6684003331859656e-07 / 3.958329447265834e-09 / 4.242888917541819e-08 / 2.859898115713063e-07 / 2.0425825542054087e-07 / 4.255278048064328e-06 / 4.538593419582914e-07 / 1.2927770179758555e-06 / 4.840614386607516e-07 / 6.826429036349635e-07 / 3.953740273881905e-07 / 1.6027712459664707e-07 / 1.277864202481348e-06 0.000153777 16
33 ADRB1_1 0.0000010659 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 9.289397717877934e-06 / 5.2109649171464235e-06 / 5.2109649171464235e-06 / 3.1219185299958266e-05 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 5.1570472200670454e-05 / 3.54688199707126e-05 / 0.00299921656722761 / 1.3062838211579366e-05 / 2.408755304649635e-05 / 1.615375160694009e-05 / 0.0006200425273220967 2.5354833517437137e-10 / 1.2841215292330722e-08 / 3.315225754524024e-08 / 8.863210863839688e-09 / 2.599695216645358e-08 / 5.874422234352583e-08 / 2.2101941341811467e-07 / 9.580348649532748e-07 / 2.32003591797698e-06 / 1.3844257761317394e-06 / 2.4253616535611087e-06 / 9.891342242857947e-06 / 1.1746244916516119e-05 / 2.092495310550426e-06 / 3.681660463815629e-06 / 1.4268112459432864e-05 0.000239944 16
34 FAM19A5_1 0.0000000251 2.051237402337122e-05 / 0.0001249119186090808 / 1.1263759452799203e-06 / 0.00014547367344876742 / 0.004362771524153584 / 6.267778266652492e-05 / 0.00036105139567184824 / 0.004298857351174951 / 0.0026702661426604127 / 0.0002944288613709527 / 0.0008619933402586612 / 0.0001395680222164631 / 0.0012393227037226365 / 0.0006503983018257066 / 0.0010353911778693099 / 0.006283046490797941 3.7316428195760516e-08 / 4.801672877175668e-08 / 2.2512706653969313e-08 / 2.2270178280725655e-08 / 1.1663586146149853e-07 / 5.1617837573062526e-08 / 9.920288294972892e-08 / 1.0628762332633252e-07 / 7.803934546881044e-07 / 1.2557942267792308e-06 / 3.618961161943627e-07 / 1.737206632640488e-06 / 1.114198886925796e-06 / 1.737206632640488e-06 / 4.390716794223026e-06 / 1.5851926645157727e-06 0.001409487 16
35 CDK6_2 0.0000001305 0.00013786395373714154 / 0.00012482662815781762 / 6.30950668542991e-06 / 3.539797690840022e-05 / 0.0021106959648809795 / 0.0019402604943496325 / 0.0004050172910570013 / 0.003362553960006399 / 0.0013208680612235583 / 0.00017037141729627674 / 0.007026007804580723 / 0.0006307912742552862 / 0.006254122709575149 / 0.000452462941181013 / 0.009290134594271832 / 0.0022577052814897595 1.9544766970910803e-08 / 3.902848227411897e-06 / 1.1734588197031495e-06 / 1.1118487852102413e-06 / 1.8215667472555084e-06 / 1.2168005067226621e-05 / 1.2378495979370532e-05 / 1.2610279737677179e-06 / 7.585840312719431e-06 / 1.7309657386672318e-06 / 1.4962029489277431e-05 / 1.155615785434093e-05 / 9.614370500489897e-06 / 5.003114862001264e-06 / 5.28580544479192e-05 / 1.4068709149077956e-05 0.002220337 16
36 C1orf54_1 0.0000004284 0.0014458717426393303 / 0.0020037138718268558 / 4.335544688590604e-05 / 0.0016610593752756947 / 6.184726372815994e-05 / 0.0001877376372184388 / 0.004687460046810221 / 2.6541144234526445e-05 / 0.0072609125485500695 / 0.00020855415394078816 / 2.305129761580306e-05 / 0.0017438515808585928 / 0.0003838064547253506 / 0.02641074680572614 / 0.0006215281984981403 / 0.004345907558402852 4.431617867534599e-08 / 9.764176338067594e-08 / 1.6551951268345963e-08 / 5.4670195572463556e-08 / 8.693119479065898e-08 / 6.467247715906918e-08 / 1.3820781181904612e-07 / 2.601353524092188e-07 / 1.4346332512235168e-06 / 9.391637246842195e-07 / 2.1381221213988253e-05 / 2.0697206630187898e-07 / 2.0216248384142136e-05 / 1.3296295127951121e-05 / 4.089595896778703e-05 / 6.182750614867968e-06 0.003194747 16
37 HOOK1_1 0.0000000509 3.2501044823812903e-07 / 2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 9.289397717877934e-06 / 0.017443989828652796 / 0.0019333915490623197 / 5.2109649171464235e-06 / 0.0003167991900078877 / 8.058554843717415e-06 / 3.54688199707126e-05 / 1.3062838211579366e-05 / 0.0004073113752386311 / 0.001077781567228248 / 2.408755304649635e-05 / 0.03666459832926511 6.576012762267339e-08 / 1.4455622042691941e-06 / 4.885610187770645e-07 / 3.76701623356669e-07 / 1.8059093721170035e-06 / 2.676171176620618e-05 / 5.749753783810232e-05 / 1.1638593888237151e-05 / 8.633538811448395e-06 / 1.5664395352028368e-06 / 2.090650282526137e-06 / 2.5661246047916315e-05 / 1.5202656143498954e-05 / 9.9612781999649e-06 / 1.6231643656615e-05 / 0.00012445882667471073 0.003621722 16
38 EVI2A_1 0.0000000779 2.0071481202007584e-05 / 1.3062838211579366e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 0.0006200425273220967 / 3.54688199707126e-05 / 0.006968336904458093 / 5.2109649171464235e-06 / 0.0019333915490623197 / 5.2109649171464235e-06 / 0.00029640089162746337 / 0.002238680629992204 / 0.0006813940301036226 / 2.408755304649635e-05 1.5609086500143182e-09 / 2.4274791706684804e-07 / 1.3635987406508816e-07 / 1.6189487637413584e-07 / 3.704245549261797e-08 / 5.850917111819974e-07 / 4.021754229335225e-06 / 5.99711639772174e-06 / 5.939256052201768e-07 / 5.306927531917352e-06 / 1.752058259452043e-06 / 3.3967361752805547e-06 / 1.4521128153120201e-05 / 2.839421384468485e-05 / 1.9278657989741134e-05 0.000856793 15
39 KDSR_1 0.0000003143 1.887107728600381e-05 / 0.0005437871552770366 / 0.002087197919276702 / 0.0001432193232982916 / 0.00021988598115354305 / 0.002087197919276702 / 0.0010434554869778357 / 0.0002441254991542676 / 8.177669445709026e-05 / 0.006227948945630897 / 0.0016193402238388898 / 0.00033206653362091303 / 0.0001432193232982916 / 3.139293208316785e-05 / 0.001424661642376461 7.774619885339959e-09 / 9.17707137009986e-09 / 6.345932895218097e-07 / 3.824093835557216e-08 / 4.870463435270994e-07 / 1.781378071484659e-07 / 1.5486153095797136e-06 / 3.2667817640867473e-06 / 9.66394881627529e-07 / 1.054382095817476e-05 / 7.511357995471599e-06 / 2.1985427007215493e-06 / 4.469268122727537e-06 / 5.302698252478667e-06 / 5.826180628047725e-05 0.00108321 15
40 TRIM69_1 0.0000000466 1.887107728600381e-05 / 0.0002441254991542676 / 0.0001432193232982916 / 0.0004863107130580812 / 0.0001432193232982916 / 0.00021988598115354305 / 0.00021988598115354305 / 0.0005437871552770366 / 8.177669445709026e-05 / 0.0016193402238388898 / 0.006227948945630897 / 0.0003935478447180597 / 0.002087197919276702 / 0.0001432193232982916 / 0.016123082594735844 1.1433357759584753e-08 / 8.836349820396399e-08 / 1.0186144265985267e-07 / 9.978329579501906e-08 / 5.327953099928334e-07 / 2.0403148485445152e-07 / 1.36202730898669e-07 / 1.8476610323825603e-07 / 1.9599293797405736e-06 / 1.3645862654437664e-06 / 4.736723443537097e-06 / 3.824375400480388e-06 / 1.7111709589036534e-06 / 5.410761494405694e-07 / 1.1672532290928993e-05 0.001913028 15
41 FAM69A_1 0.0000000702 0.0013130417279779386 / 0.00015668136762185704 / 0.000580627296776329 / 0.00021513618339111576 / 0.0006379488254521119 / 0.0038002956245117296 / 0.00023863087793556863 / 0.009089976463332457 / 0.009732706737130784 / 0.0015596001225492795 / 0.0012028677089548085 / 0.0020078773138146426 / 0.0007003039227988429 / 0.010574324269088433 / 0.00442535226656398 5.207979195444387e-10 / 2.3954906890799492e-08 / 8.376642315944637e-08 / 3.029086308872845e-09 / 8.2602839443737e-08 / 4.5432680388905903e-07 / 3.4215164228215663e-07 / 3.6227709430270065e-07 / 1.1119851588379871e-06 / 9.884962787115456e-07 / 6.58864064133256e-07 / 1.9066424564105585e-07 / 1.0175118608827892e-07 / 9.736821003526402e-06 / 2.2836387735375516e-06 0.003082358 15
42 MCF2_1 0.0000000950 0.002107325343692074 / 0.0007073001228128905 / 0.0016226906289916678 / 0.013331886853589549 / 0.004410274724633273 / 0.004410274724633273 / 3.1219185299958266e-05 / 0.0011323441860117745 / 0.005133998810813905 / 8.807499017205126e-05 / 0.008672939675174867 / 3.54688199707126e-05 / 0.0016232581034909483 / 8.11064679353273e-05 / 0.019751746709410014 2.8385942053147423e-07 / 7.000874559889031e-07 / 1.0191814816838582e-06 / 1.937510906526569e-06 / 1.219795851846249e-06 / 1.1273301221243648e-06 / 7.451700758866295e-08 / 4.510350188873355e-07 / 1.6503324272286632e-06 / 9.824741991349808e-05 / 7.86885268932808e-06 / 2.4523766799232255e-06 / 8.771491504288576e-06 / 4.472728712108301e-06 / 6.181222965809451e-06 0.004209327 15
43 DNMT3A_1 0.0000000038 3.2501044823812903e-07 / 2.7109747094287326e-07 / 9.224071980226081e-07 / 1.615375160694009e-05 / 9.289397717877934e-06 / 0.017443989828652796 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 5.1570472200670454e-05 / 0.0006813940301036226 / 5.2109649171464235e-06 / 2.408755304649635e-05 / 0.0003167991900078877 / 0.04025623380130843 / 0.016412811603890378 8.647692450087712e-10 / 3.609830399524262e-08 / 1.0850349172583042e-07 / 4.2367786991922625e-07 / 5.547034323026097e-08 / 4.995600154079587e-06 / 9.034850264291034e-07 / 1.1942660873924224e-07 / 3.4764046668097013e-06 / 1.1899456022044518e-05 / 4.064896475030508e-06 / 5.950697198132815e-06 / 2.1639192493163854e-06 / 0.0003267886041800874 / 2.5073506475872135e-05 0.005016004 15
44 RAP1GAP_1 0.0000001086 1.3062838211579366e-05 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 3.54688199707126e-05 / 5.2109649171464235e-06 / 2.7109747094287326e-07 / 9.289397717877934e-06 / 8.058554843717415e-06 / 5.2109649171464235e-06 / 2.408755304649635e-05 / 6.979794879972793e-06 / 5.1570472200670454e-05 / 9.224071980226081e-07 / 0.0004073113752386311 1.0234263973416661e-07 / 8.919463455114289e-08 / 3.3072632243081114e-08 / 1.5105555334027616e-07 / 2.5836122972488502e-08 / 1.2756238211643116e-07 / 9.299416219218907e-08 / 2.1342000804921115e-07 / 7.37724046840261e-07 / 6.300687009130246e-07 / 3.3529930477004465e-06 / 2.385355833544641e-06 / 9.364193044327943e-08 / 5.244484117278139e-06 4.06208E-05 14
45 GCNT1_2 0.0000000002 2.78484877909426e-05 / 4.864296167501907e-07 / 9.764023441666015e-05 / 2.140496501618477e-08 / 0.00016651089487352638 / 3.0074215404236193e-05 / 0.0006617980305097352 / 1.3483681400210042e-06 / 4.031241782169131e-05 / 1.1981309904526152e-06 / 5.587185227944235e-07 / 1.0829140297466289e-09 / 7.220251902586713e-08 / 3.539399887995572e-05 1.8148339446273985e-07 / 6.847165231186148e-07 / 2.165545875875814e-05 / 2.3188274882197003e-07 / 6.0280690987430294e-06 / 5.2750455191025595e-06 / 4.06671138458547e-05 / 1.2997762974345022e-06 / 2.2170187832829583e-06 / 6.9576009368884445e-06 / 9.170085944984048e-06 / 1.1905756638522483e-06 / 5.8239343353291375e-06 / 2.5038906043292028e-05 7.59475E-05 14
46 ACVR2B_1 0.0000024645 0.004342013504637762 / 0.010062997503423064 / 0.01546878234616017 / 0.0043172887751955534 / 0.004147048109487421 / 0.0027366161949255864 / 0.004302356273800125 / 0.003851105873342487 / 0.010924554738209911 / 0.0034419337702655166 / 0.0016993523409038112 / 0.008815441252326467 / 0.010035816045194686 / 0.0003588157506217931 4.6969645977238944e-08 / 1.0646048244254027e-06 / 2.074984122638114e-06 / 1.6464210539762824e-06 / 3.55074742901801e-07 / 8.336014361253352e-07 / 1.0819897944403119e-06 / 6.649001393280087e-07 / 1.771560615564129e-07 / 2.1882250573351623e-06 / 5.884742871708681e-07 / 1.359935106570381e-05 / 2.757047405189331e-06 / 3.7316428195760516e-08 0.006036009 14
47 FLII_1 0.0000003706 0.013438701196916187 / 0.0013131196768949175 / 0.001313597832987636 / 0.010966427251690712 / 0.0010967995115722952 / 0.00283637665495315 / 0.020637719307260594 / 0.009544509177234737 / 0.011113919331766907 / 0.002612407689400646 / 0.00014659710165947198 / 0.011743117027967754 / 0.003613135281467632 / 0.021113557190889712 2.0358630016163756e-07 / 9.38178289658818e-07 / 1.5768550290633048e-06 / 4.170842922005371e-07 / 1.2667845868111258e-06 / 5.267900245960507e-07 / 1.0328138955557601e-05 / 2.5703309767846595e-06 / 9.713959639172909e-06 / 4.879856421117728e-06 / 5.689594876108628e-07 / 5.210656857814663e-06 / 2.5072452506982253e-06 / 2.1338889654131307e-06 0.00796357 14
48 TGS1_1 0.0000000593 0.005817871625455744 / 0.001612584660708291 / 0.0053998526759721725 / 0.01862777129511709 / 0.0053998526759721725 / 0.01862777129511709 / 0.007245502894805505 / 0.0077845190703610834 / 0.006739142831934305 / 0.02903454585336941 / 0.04017463251009088 / 0.012410587219941139 / 0.022439998212103154 / 0.022439998212103154 1.1383417891948003e-06 / 3.9578672189598e-07 / 9.316488159288118e-07 / 1.3710585742644193e-06 / 2.6082574074268862e-06 / 1.3166677315221278e-06 / 1.7045413888506067e-06 / 3.708237186148934e-05 / 5.818012600528764e-06 / 1.560303853533272e-06 / 2.2843722976730473e-05 / 8.803523078622629e-06 / 3.9399829491464125e-06 / 3.3285882689135296e-05 0.014553902 14
49 XG_2 0.0000000005 1.3401582342156554e-08 / 1.7203065067402312e-07 / 1.3942380334535833e-06 / 4.659755401849588e-08 / 5.207246052888057e-07 / 1.892412103400743e-05 / 1.017482106342708e-05 / 4.835640776889601e-06 / 2.3498756278510995e-06 / 1.096889887353167e-06 / 7.359704703027111e-07 / 3.633081984870721e-07 / 2.0535846739106096e-05 1.9199076986833634e-08 / 5.521935167514162e-09 / 3.002088015685159e-08 / 1.1673991664313873e-07 / 2.339150064869274e-07 / 7.850967660487343e-07 / 4.37609121214664e-07 / 4.313448454057681e-06 / 4.476536711400614e-06 / 4.1360359096373095e-07 / 2.1997972567339213e-06 / 1.1288300480073834e-05 / 7.933567388992601e-06 4.70488E-06 13
50 PCDH17_2 0.0000000072 7.492219023207615e-07 / 1.6974372024295342e-05 / 1.6060512405884523e-05 / 3.680752556412065e-06 / 6.21390552863653e-07 / 6.893999398193879e-07 / 6.419532166056714e-06 / 0.00011541115360842292 / 3.212738000062656e-05 / 7.73108993011784e-06 / 0.00033397296479027066 / 2.702881264505673e-05 / 1.030767276264569e-05 6.224247092494593e-07 / 1.908891295970431e-06 / 1.876118975664838e-08 / 6.86071862572385e-07 / 2.666345798254567e-06 / 2.440951781485953e-06 / 1.963413625423467e-06 / 2.0652089761761355e-06 / 1.494707065464428e-06 / 8.283723353251414e-06 / 7.600283334205516e-05 / 1.3148299792014698e-05 / 1.7938478170268224e-06 4.39826E-05 13
51 FCGRT_4 0.0000000001 1.6626318528356214e-07 / 4.1454120935946585e-08 / 1.2856777469915098e-05 / 2.655269050407992e-06 / 4.4947875774412546e-05 / 0.00076179506295693 / 8.948391869055381e-06 / 2.7424661803535043e-05 / 4.648680805728703e-06 / 1.9163242045014747e-06 / 1.4485958804049422e-06 / 2.5267554662269253e-05 / 6.405110910660664e-05 2.1372152215021398e-08 / 2.057088830240376e-08 / 5.269671774798225e-06 / 3.982312076585435e-06 / 2.495582032458844e-06 / 2.870333661857787e-05 / 9.483756578219822e-07 / 1.25762087754457e-05 / 9.76651146667424e-06 / 2.661769663306888e-05 / 1.3930567108132102e-05 / 1.1400150976360551e-05 / 2.349102225413189e-05 7.35514E-05 13
52 PPAPDC2_5 0.0000000000 4.5169034086855336e-09 / 9.742548139480632e-07 / 5.217506022585185e-05 / 3.5026216529567156e-06 / 2.4673093720667337e-06 / 5.3153783898022636e-05 / 1.3937823180284198e-07 / 7.982877170487641e-08 / 6.508221395478821e-05 / 0.019956257662802263 / 6.700896966172976e-05 / 3.21116578085472e-05 / 6.01263079824308e-05 1.1212152252396135e-09 / 7.076208121664563e-08 / 4.726350666602277e-08 / 1.0531985708720735e-07 / 2.551343424529328e-06 / 1.7296428659338845e-05 / 2.9345983642597263e-07 / 8.883747046871617e-07 / 7.1695441364551825e-06 / 0.00011902489330085526 / 3.9052877174834575e-06 / 2.895020091940764e-06 / 9.487544302661349e-06 0.001561006 13
53 OTUD1_1 0.0000066678 0.0001143785517442608 / 7.116374713072327e-05 / 0.0013570458512569155 / 0.002178697316418811 / 0.0038052297192277813 / 0.0007240451812165356 / 0.0019400441864677392 / 0.0023946671170695885 / 0.011483919297924996 / 0.0019400441864677392 / 0.0011976310136393364 / 8.349604404582616e-05 / 0.00782841795432341 2.4271728701188334e-07 / 2.716202606694871e-08 / 4.962003898295528e-07 / 1.3066402773912248e-06 / 2.94591397016505e-06 / 7.18702142240598e-07 / 1.4280279163673197e-07 / 7.547674557111806e-06 / 6.26163745905449e-06 / 6.443362593686641e-07 / 5.452589541736924e-06 / 0.00036648972212703103 / 3.720187278061506e-05 0.002701445 13
54 IRS2_2 0.0000000037 7.220251902586713e-08 / 2.140496501618477e-08 / 1.0829140297466289e-09 / 4.1398213999064624e-06 / 1.5415033312027603e-05 / 1.1605014260398891e-06 / 3.934765724180659e-07 / 1.4279427966735553e-05 / 4.864296167501907e-07 / 2.4103457859893014e-05 / 5.7336006475198166e-05 / 5.9617084438303865e-06 2.2709629567530206e-06 / 2.0247353106423544e-07 / 1.3837713193741096e-07 / 1.0531985708720735e-07 / 1.1721035444282598e-06 / 5.783428499209018e-07 / 1.1344098678195103e-05 / 1.301499532725973e-06 / 8.452688032747793e-06 / 3.4078210994409503e-06 / 3.0574198226347985e-06 / 4.1558712164911445e-06 1.02809E-05 12
55 AKAP7_1 0.0000000393 3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 1.615375160694009e-05 / 2.0071481202007584e-05 / 5.2109649171464235e-06 / 5.1570472200670454e-05 / 2.408755304649635e-05 / 0.00025640470531776904 / 0.001077781567228248 / 0.0004073113752386311 1.765676819518555e-07 / 3.972296959609109e-08 / 3.2695301895520668e-06 / 1.5934388217060153e-05 / 3.721417159936691e-06 / 5.5785045280072256e-06 / 4.163536679627491e-06 / 5.719017833567702e-06 / 1.026744929609048e-05 / 2.579776719840281e-05 / 2.8764328668118886e-05 / 2.5301330015839306e-05 0.000155783 12
56 PCMTD2_1 0.0000000068 0.0003167991900078877 / 9.289397717877934e-06 / 9.224071980226081e-07 / 3.54688199707126e-05 / 3.2501044823812903e-07 / 2.408755304649635e-05 / 2.0071481202007584e-05 / 0.0006813940301036226 / 6.979794879972793e-06 / 0.0005120167928359619 / 8.058554843717415e-06 / 0.0019333915490623197 5.861015607960784e-07 / 3.59230415078595e-07 / 6.529460316458851e-08 / 3.4690122473485e-07 / 8.012676260040657e-08 / 1.8059093721170035e-06 / 8.298018416641704e-07 / 9.470642017366756e-05 / 1.948928228321219e-06 / 2.3571691916825546e-06 / 2.8538696820324185e-07 / 6.729556671438922e-06 0.000295734 12
57 ANXA11_1 0.0000005151 2.408755304649635e-05 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 9.289397717877934e-06 / 0.004410274724633273 / 3.54688199707126e-05 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 0.0019333915490623197 / 4.559947241482223e-05 / 6.979794879972793e-06 / 5.1570472200670454e-05 3.3435882766015197e-08 / 1.9719084534841054e-07 / 7.15064607927488e-08 / 6.417376094706333e-07 / 4.257425478509546e-06 / 1.5694978207696109e-06 / 3.888433936368708e-06 / 5.0965829347694e-07 / 3.057977557175645e-06 / 4.306237992774822e-05 / 3.6558508721641653e-06 / 2.5076660883555645e-06 0.000545266 12
58 CYP4F22_1 0.0000027180 1.887107728600381e-05 / 0.0001432193232982916 / 0.0003242200414121999 / 0.00011602560329098725 / 0.0001432193232982916 / 0.0010434554869778357 / 0.002087197919276702 / 0.0004963923899259765 / 0.0002441254991542676 / 0.006227948945630897 / 0.00011484315511043709 / 0.00021988598115354305 1.855878357665062e-07 / 4.5205001853266315e-06 / 1.6230646465299277e-07 / 1.9937810791618053e-06 / 2.459173869598607e-06 / 1.418028686271357e-06 / 3.0798872921235664e-06 / 1.4638448696185004e-05 / 4.174632323174143e-06 / 6.960889474122188e-05 / 8.13226356593833e-06 / 4.0324998931408915e-06 0.000931617 12
59 FAH_1 0.0000000544 9.971939174478468e-05 / 0.0014783442733670397 / 2.051237402337122e-05 / 1.1263759452799203e-06 / 1.7999540459370774e-05 / 0.005398390884784092 / 0.0002944288613709527 / 0.0026702661426604127 / 0.0028963504457353837 / 0.0008619933402586612 / 0.0028963504457353837 / 0.0001395680222164631 1.0046436835312793e-07 / 3.154681248422513e-08 / 5.394104603263994e-07 / 2.7366646890842144e-07 / 5.480720006502052e-08 / 1.6335104962830753e-06 / 1.8420227314596207e-06 / 7.083329258820255e-06 / 2.102391157291273e-06 / 1.7455247460827437e-06 / 0.00019992317018209673 / 1.9765391249129614e-06 0.001397921 12
60 PRSS35_1 0.0000001503 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 2.408755304649635e-05 / 4.0242980256377906e-05 / 0.011066537502725836 / 0.017443989828652796 2.153587369784463e-08 / 1.0035560526801471e-07 / 1.5112245406129175e-07 / 8.734069561342572e-09 / 6.456193736055655e-07 / 1.1915844331577668e-07 / 1.2496790707220447e-06 / 5.187593428631375e-06 / 7.677479865507362e-06 / 4.694603023798112e-06 / 2.4926729322946157e-05 / 6.095320536599329e-05 0.002384904 12
61 ARID2_1 0.0000000008 3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 5.1570472200670454e-05 / 1.3062838211579366e-05 / 2.7109747094287326e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 2.408755304649635e-05 / 3.54688199707126e-05 1.4085604923353669e-09 / 2.1559634977578997e-08 / 3.073451224470281e-08 / 6.67627891847618e-07 / 9.45287179820993e-07 / 1.6026605078229915e-06 / 2.8723110644674783e-07 / 6.593293352572093e-08 / 1.76044274336364e-06 / 2.2796504010207573e-06 / 4.083275206575873e-06 1.52054E-05 11
62 GBE1_2 0.0000000002 1.0829140297466289e-09 / 1.1605014260398891e-06 / 2.140496501618477e-08 / 2.4103457859893014e-05 / 1.3483681400210042e-06 / 6.882770012055959e-06 / 3.539399887995572e-05 / 4.926323640851737e-05 / 4.864296167501907e-07 / 5.7336006475198166e-05 / 4.1398213999064624e-06 6.14215099741482e-11 / 8.633691649398072e-08 / 3.1558675335691306e-07 / 6.649001393280087e-07 / 1.5766900825696111e-06 / 4.000342337039938e-06 / 2.5158332022026807e-06 / 1.3914120255170465e-05 / 3.7817976979062494e-06 / 3.526532094488005e-06 / 1.4262192253107675e-06 1.63761E-05 11
63 FEZF1_2 0.0000000048 2.140496501618477e-08 / 1.0829140297466289e-09 / 1.5415033312027603e-05 / 0.0006617980305097352 / 3.934765724180659e-07 / 4.864296167501907e-07 / 3.539399887995572e-05 / 7.220251902586713e-08 / 1.1605014260398891e-06 / 1.3483681400210042e-06 / 2.4103457859893014e-05 3.290701334443236e-08 / 5.517282972397794e-07 / 2.461670483939178e-07 / 3.7377331388541626e-05 / 5.142883274641414e-06 / 4.043272115285976e-06 / 2.938617309558263e-05 / 4.8239179614945364e-05 / 7.309372974198873e-06 / 1.022853119829971e-05 / 2.3639654167207866e-05 6.72904E-05 11
64 ACACB_2 0.0000000003 2.135362618124217e-07 / 2.2402150648537843e-08 / 3.983245164121986e-08 / 4.136645421698625e-06 / 3.025796797872868e-08 / 0.0005588402339511055 / 8.584401402568793e-06 / 1.471749614726362e-06 / 0.0003892038851689398 / 3.8987044705871713e-07 / 8.994816753298524e-06 1.3484124764189522e-08 / 4.706709396786997e-07 / 9.271074896090571e-07 / 5.302698252478667e-06 / 2.0500342574990374e-06 / 1.551726788306523e-06 / 1.781550905952925e-05 / 7.047194494372442e-06 / 1.9709880947249853e-06 / 5.20649578902775e-06 / 1.1244039336708898e-05 8.83571E-05 11
65 CUX2_1 0.0000000906 0.0001432193232982916 / 1.887107728600381e-05 / 0.0003935478447180597 / 0.00033206653362091303 / 0.00021988598115354305 / 0.0001432193232982916 / 0.0007228851823325908 / 0.00036719870368562404 / 0.00011484315511043709 / 0.00011602560329098725 / 0.0004963923899259765 1.1673991664313873e-07 / 1.284325373822431e-07 / 1.6698077738985942e-06 / 6.902441910511023e-07 / 3.4215164228215663e-07 / 3.007835341834974e-06 / 1.919682119213592e-06 / 1.5381709053459223e-06 / 3.6946271417190457e-06 / 6.898390776268342e-06 / 6.529025230777642e-06 0.000278923 11
66 H2AFY2_1 0.0000000422 0.0008581803853921776 / 1.1263759452799203e-06 / 2.051237402337122e-05 / 0.0031060111248571412 / 0.0005345324666238675 / 0.0001395680222164631 / 4.369070707050029e-05 / 9.971939174478468e-05 / 0.0003301911422383287 / 0.006072266622156599 / 0.0002944288613709527 5.135300319990053e-08 / 7.661142091219907e-10 / 7.618409522067726e-07 / 1.0083404706814497e-06 / 8.282189290342112e-07 / 1.147296721987914e-06 / 5.029041750177964e-07 / 2.8221672702900553e-06 / 6.87678977620866e-06 / 1.6817202963510347e-06 / 1.5631172248405328e-05 0.001045475 11
67 SCNN1G_1 0.0000000555 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 6.979794879972793e-06 / 0.017443989828652796 / 2.0071481202007584e-05 / 5.2109649171464235e-06 / 0.0006200425273220967 / 9.224071980226081e-07 / 9.289397717877934e-06 / 5.2109649171464235e-06 1.613539402686862e-07 / 3.7316428195760516e-08 / 6.371651336534961e-07 / 1.237673510094506e-06 / 6.701672901978117e-05 / 1.972791863813969e-06 / 1.1012098448593559e-06 / 1.967576698919758e-06 / 4.9444208073750495e-06 / 1.3324922817800096e-05 / 3.1007051507707384e-05 0.001646658 11
68 MICAL2_1 0.0000002288 0.00049387566368266 / 8.019236578134864e-05 / 0.004971246918927329 / 0.004078510310946084 / 0.0004290110230937398 / 0.00043106377145357623 / 0.0006315592529035093 / 0.001914379403049941 / 0.0034656404808317003 / 0.0025176594807100345 / 0.00031707617750638764 2.1762204790117787e-09 / 3.2272833090138044e-07 / 7.827762172740352e-08 / 6.06643046842526e-08 / 1.3129367317358875e-07 / 4.830225730426315e-07 / 3.928902637745179e-07 / 3.9101702420209316e-06 / 9.84639797132252e-07 / 6.086458081584004e-07 / 2.1279294679682064e-06 0.001757292 11
69 SWT1_2 0.0000000170 2.9659818641279015e-06 / 0.00029176699231122706 / 1.5046470240543167e-06 / 0.004644223206500837 / 0.010900569633432996 / 2.7522055206568103e-06 / 0.00013583448483780612 / 0.004741348922243877 / 0.0003486124797281799 / 7.371030323660905e-05 / 0.00018181245959759176 4.9187331773462e-08 / 2.5012881769902937e-08 / 6.268977803019969e-07 / 1.3528096310298506e-06 / 2.783451231831402e-06 / 2.565078990567409e-07 / 8.86664377274927e-07 / 5.964528017547677e-07 / 6.174004769239488e-07 / 9.308945080733071e-06 / 1.0484586327302643e-05 0.001938646 11
70 PDE6B_1 0.0000013889 1.228676574562544e-05 / 0.0011323441860117745 / 8.807499017205126e-05 / 0.002107325343692074 / 0.0014854545690578267 / 0.019751746709410014 / 0.004410274724633273 / 0.005133998810813905 / 0.0020170234515396526 / 0.004410274724633273 / 0.0016232581034909483 5.065661868983875e-07 / 7.17995131525044e-07 / 4.053723016913819e-06 / 8.937583768343871e-07 / 1.1790960971280032e-06 / 4.154079216411671e-06 / 1.726041894379202e-05 / 1.0279309246897823e-05 / 0.0003143462985658359 / 8.736287586605331e-06 / 6.384516835905964e-05 0.003833824 11
71 FUT11_4 0.0000000000 6.74235053631547e-08 / 4.771768758103407e-07 / 3.1959674906838326e-06 / 1.3575216074689785e-06 / 1.8241579597627434e-05 / 8.479913437625553e-06 / 8.284064752711457e-06 / 0.00018644210000651158 / 5.006828327534464e-05 / 8.236105425032711e-06 2.4685536420123714e-08 / 4.05022735179046e-08 / 8.733965575196973e-08 / 1.3604574320151334e-07 / 8.805480517015095e-07 / 2.385334687979164e-07 / 4.9124234903367736e-06 / 9.92600195563702e-06 / 3.057977557175645e-06 / 1.118638923657507e-06 2.8485E-05 10
72 CRMP1_2 0.0000000000 2.0535846739106096e-05 / 1.3401582342156554e-08 / 2.225580423517811e-06 / 1.3942380334535833e-06 / 0.00024560379848655926 / 4.659755401849588e-08 / 2.1627385395830295e-05 / 3.633081984870721e-07 / 3.4192931304829014e-06 / 0.0006879396808549597 7.620811819896486e-06 / 4.382658462880079e-06 / 1.3863143636682347e-05 / 1.3319999198783528e-06 / 1.2152438530817433e-05 / 4.382658462880079e-06 / 8.241971999095359e-06 / 9.923377128421226e-06 / 6.249002717536056e-06 / 5.602552813683701e-05 9.83169E-05 10
73 ATP2B3_2 0.0000000043 0.0003163773097135214 / 7.172518710454511e-06 / 7.245191987655973e-05 / 8.741819060152168e-05 / 5.359794419137135e-05 / 4.430782193013355e-05 / 0.00023847763377654726 / 4.824032561244295e-06 / 4.5251992585881006e-07 / 0.0004949659728438359 2.4865375915662647e-06 / 1.5062494177669247e-06 / 1.688540465706646e-06 / 1.6196306143315863e-06 / 2.748486185526218e-07 / 2.086193436943505e-05 / 2.6861282329371614e-06 / 5.547613575367754e-06 / 3.303970125073177e-05 / 1.1524582203343819e-05 0.000132005 10
74 KLHL23_2 0.0000000192 6.893999398193879e-07 / 6.419532166056714e-06 / 2.702881264505673e-05 / 6.21390552863653e-07 / 0.0017884623559603927 / 1.6974372024295342e-05 / 0.001013875347197311 / 7.396819433180742e-05 / 0.0005052900676961513 / 7.73108993011784e-06 4.968239365259682e-09 / 1.7135370925414656e-07 / 2.932867120091765e-07 / 3.3425571794650135e-07 / 3.0548311202804935e-06 / 3.451257716664588e-06 / 2.1699721245824695e-06 / 4.163536679627491e-06 / 2.920396755301379e-05 / 6.218195828657096e-06 0.000344106 10
75 PNMAL1_1 0.0000000001 9.224071980226081e-07 / 9.289397717877934e-06 / 3.54688199707126e-05 / 8.058554843717415e-06 / 2.408755304649635e-05 / 2.7109747094287326e-07 / 4.491442887170463e-06 / 3.54688199707126e-05 / 0.003763661611010697 / 2.0071481202007584e-05 2.398130659400807e-08 / 3.3728825978612466e-08 / 2.556768800894887e-07 / 1.098753545263955e-07 / 8.352881705441376e-07 / 4.562304305269522e-07 / 1.08096832891062e-06 / 1.1362044976111473e-06 / 3.965156059753076e-06 / 2.532544882586065e-07 0.000390179 10
76 DPP9_1 0.0000000903 0.0001432193232982916 / 0.009103599585178113 / 0.001710012299865077 / 0.00011602560329098725 / 0.0004963923899259765 / 0.0002441254991542676 / 1.887107728600381e-05 / 0.00021988598115354305 / 0.00033206653362091303 / 0.00011484315511043709 2.8179456082348394e-09 / 2.727075953865357e-06 / 1.168813758935927e-06 / 3.371222633783479e-08 / 4.426276839356633e-07 / 7.736320976296901e-08 / 1.0399111877082387e-07 / 5.1926198984756595e-08 / 2.443030575808895e-07 / 5.2490814290897396e-08 0.001249904 10
77 GPC2_1 0.0000011913 0.00038318838044808375 / 0.0005893191501630695 / 0.00015165886425239433 / 0.0001877376372184388 / 7.79155859315203e-05 / 3.4006794328894204e-05 / 9.771266164691155e-05 / 0.0021345675385303783 / 0.009896861713608592 / 0.00046672125625950257 5.8322357175018814e-08 / 3.819394841783607e-06 / 4.185755315703245e-06 / 8.9047725673033e-06 / 1.688540465706646e-06 / 1.3977429686239098e-06 / 7.632716224230066e-06 / 2.3986226430486996e-06 / 8.321983027984269e-05 / 1.1589901935051875e-05 0.001401969 10
78 RBM27_1 0.0000328921 0.00019056149396649567 / 1.0762691116666793e-05 / 0.00016655530309410099 / 0.00014532888285824017 / 0.008666672397448167 / 0.0011926586521531122 / 8.547883129077166e-06 / 0.0005615344938163923 / 0.0009516879673421394 / 0.008666672397448167 3.272103105129996e-05 / 6.146543343371357e-05 / 3.6952686083686934e-05 / 1.4957676302550525e-05 / 0.00044169721387816736 / 0.0002538625473566664 / 6.352688846998858e-05 / 0.00045432042455129443 / 0.0011408393624126037 / 4.513400088366357e-05 0.002056098 10
79 HOXD13_1 0.0000000916 2.7109747094287326e-07 / 3.2501044823812903e-07 / 3.1219185299958266e-05 / 0.0027465190930067913 / 0.017443989828652796 / 0.016412811603890378 / 9.224071980226081e-07 / 0.0006813940301036226 / 5.2109649171464235e-06 / 9.289397717877934e-06 1.1132672619587453e-06 / 2.168405947503928e-06 / 8.632653046332761e-07 / 2.661765393750704e-07 / 2.9706339258865287e-05 / 9.772801528529325e-07 / 6.119157345497534e-06 / 4.403524887759186e-05 / 3.9616874289254276e-05 / 1.5034368122270238e-05 0.003733195 10
80 TFCP2_1 0.0000155106 0.0032558342640986913 / 0.003164163749771866 / 0.007834759439000943 / 0.0006574116836031526 / 0.0004120327968848806 / 0.002547330192150467 / 0.023671720746870278 / 0.01008298563196674 / 0.003825348546364798 / 0.012865293420775923 1.7408199559491215e-08 / 3.662770588769913e-08 / 2.4230602059049713e-09 / 7.057607420139844e-09 / 5.864919427085214e-09 / 4.067269852743229e-09 / 1.2958775867702838e-07 / 2.4061415002001486e-07 / 1.04445857509862e-08 / 8.406826338931904e-09 0.006831688 10
81 MLC1_2 0.0000000000 2.3317798357459768e-08 / 3.950726068803937e-05 / 7.200240759113992e-08 / 6.485065795284483e-06 / 2.72061163246224e-07 / 1.0914465968113564e-09 / 8.785255275890593e-07 / 2.260908840956264e-06 / 3.4091273206128115e-06 3.821355197181773e-10 / 4.815234643922553e-08 / 4.880618111292151e-07 / 6.535686301472137e-07 / 5.01553847742357e-09 / 9.071527094231567e-07 / 1.561363617000177e-06 / 3.5739771593065375e-08 / 6.799019141310347e-07 5.87882E-06 9
82 NUDT10_1 0.0000000252 5.2109649171464235e-06 / 2.0071481202007584e-05 / 1.3062838211579366e-05 / 5.2109649171464235e-06 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 6.979794879972793e-06 / 4.559947241482223e-05 8.543772901530404e-08 / 3.0560088249163646e-06 / 3.4630204183867344e-06 / 1.75703491771623e-06 / 8.596645616376963e-06 / 6.6659679642121145e-06 / 6.998717296179836e-06 / 6.1225414982440546e-06 / 6.176627272024636e-05 1.57573E-05 9
83 ABHD6_5 0.0000000011 3.358358494818591e-05 / 2.9134927252228483e-07 / 2.9938150702443185e-06 / 2.052332708446901e-06 / 1.4490238008299036e-06 / 3.2017228485917034e-06 / 7.134949223903302e-05 / 9.16995079558899e-05 / 3.381829650307869e-05 1.889438601616299e-06 / 1.2766781385500044e-06 / 2.363524198350829e-06 / 3.917011825001329e-06 / 7.303755032082717e-06 / 1.3315374780889495e-05 / 2.4860974232140882e-05 / 1.6960856788042183e-05 / 1.807142776332772e-05 2.67155E-05 9
84 NDST4_2 0.0000000040 2.668064610627935e-06 / 6.6526771052306895e-06 / 1.1230314579614556e-05 / 1.8473033200489925e-05 / 6.627915836434039e-07 / 8.256090054064686e-05 / 1.116884259988551e-05 / 5.25757451328789e-05 / 9.075192641901149e-05 9.235058235332018e-08 / 3.739290293217579e-07 / 8.778520319265194e-07 / 4.805213523603749e-07 / 9.024033737327827e-06 / 1.2463662086892492e-06 / 2.593919669520066e-06 / 1.5869215394518834e-05 / 6.9327764685965786e-06 3.07494E-05 9
85 POU3F2_5 0.0000000000 7.323883195296019e-07 / 5.815521557860219e-06 / 1.9482696423142906e-05 / 0.0007454381092335746 / 1.161047392436168e-05 / 1.810779009958944e-06 / 4.647086083767663e-06 / 1.4526839867076841e-05 / 3.820854417705018e-05 4.118783678942697e-07 / 1.9018218973456198e-06 / 5.1834489629063885e-06 / 0.00016912370949213852 / 1.1280051635983909e-05 / 3.251853365907979e-06 / 6.769433778371573e-06 / 2.785132091011529e-05 / 7.035159184655411e-05 9.35858E-05 9
86 RND2_1 0.0000002063 3.2501044823812903e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 2.408755304649635e-05 / 0.0003167991900078877 / 9.289397717877934e-06 / 9.224071980226081e-07 / 0.0006200425273220967 / 0.0019333915490623197 4.692355741850912e-08 / 3.057428987575251e-08 / 1.287838376941801e-06 / 6.249875151319963e-07 / 2.5823199743834396e-06 / 2.0615635366014647e-06 / 1.0191814256901842e-06 / 1.8943189562108068e-06 / 2.0339342639032117e-05 0.000325095 9
87 TEKT2_1 0.0000012269 3.2501044823812903e-07 / 0.00299921656722761 / 2.7109747094287326e-07 / 6.979794879972793e-06 / 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 0.0019333915490623197 2.626807545548127e-07 / 8.972858217500653e-07 / 8.188038459526457e-05 / 1.2353713533928581e-05 / 4.657480324879461e-05 / 6.734781530483014e-06 / 3.917368514292802e-05 / 4.398198496660895e-05 / 3.85813042649088e-05 0.000552853 9
88 RCOR1_1 0.0000002629 0.0035374364838401885 / 0.0005794708000429308 / 0.004598611207763406 / 0.00027838639004009185 / 0.00254170936910902 / 0.0007730790428095843 / 0.0008116048904747243 / 0.00028760490535839194 / 0.0006209741142612609 2.12095972377237e-08 / 5.371804546576567e-07 / 1.3631627975922064e-06 / 1.3930567108132102e-05 / 7.320109762709196e-06 / 3.5012227758823163e-06 / 9.972925901562962e-06 / 5.848283608879877e-06 / 1.9939940203933426e-05 0.001558764 9
89 SH3GLB1_1 0.0000001142 1.1263759452799203e-06 / 0.0002944288613709527 / 1.7999540459370774e-05 / 0.009181416163184238 / 0.0001249119186090808 / 0.001133267650419163 / 0.0026702661426604127 / 0.005398390884784092 / 0.00014547367344876742 5.021137237572428e-08 / 1.412114735889678e-07 / 2.6082574074268862e-06 / 2.1694530129992346e-06 / 2.622668544008386e-06 / 1.3863143636682347e-05 / 2.2950455177001124e-05 / 8.882430105407664e-06 / 8.761908558227523e-06 0.002107476 9
90 ZCCHC5_1 0.0000003387 0.0002944288613709527 / 0.004641723683002966 / 0.00036105139567184824 / 0.0036790499750236597 / 0.0005345324666238675 / 0.0021653473543332357 / 0.0067509647795811235 / 0.0033178709219427965 / 0.0001395680222164631 2.1634030409586368e-05 / 1.0447439952129488e-05 / 4.841492876651217e-06 / 8.425020418700623e-06 / 1.7550566576642783e-06 / 1.829374010437789e-05 / 0.00016237480333105512 / 2.4267895369009183e-05 / 1.021655106614923e-05 0.002431615 9
91 EVI2B_1 0.0000000810 0.0005654433700885616 / 0.0021345675385303783 / 0.0010514734188248587 / 0.01706732677471782 / 0.00016882475928990226 / 0.0017046060667733898 / 1.7173658335771082e-06 / 0.0010760707198761224 / 0.01365229997365103 4.967070750533046e-07 / 9.339254057047784e-06 / 2.37004080182631e-05 / 1.7573172310813478e-05 / 4.067330085914587e-07 / 1.0577974069325492e-06 / 9.173510310512699e-06 / 1.887257789753108e-05 / 6.115093766942535e-05 0.004158037 9
92 EPC1_2 0.0000000072 0.0034390541604176214 / 0.0002448208689788285 / 0.01617199881991826 / 0.02211371791626479 / 0.0025035638269418226 / 0.01851025775546256 / 0.006305703578524486 / 0.00515664879236201 / 0.009067920198647179 5.695617165978249e-07 / 1.1672960349256724e-07 / 2.840596912722915e-06 / 6.081404109618168e-06 / 2.4211525355218317e-06 / 1.1016073014221325e-05 / 1.0934695006353887e-05 / 4.4117963688512546e-05 / 2.106616906903645e-05 0.009279298 9
93 VAX1_2 0.0000000005 1.3401582342156554e-08 / 4.659755401849588e-08 / 4.835640776889601e-06 / 7.359704703027111e-07 / 1.096889887353167e-06 / 1.3942380334535833e-06 / 5.207246052888057e-07 / 3.4192931304829014e-06 7.755118664932962e-08 / 9.171116579440387e-08 / 1.1013084399854174e-05 / 4.524910966526263e-06 / 1.529385415217493e-06 / 1.427223677524831e-05 / 1.4066320814267013e-05 / 2.2774582231147903e-05 1.50784E-06 8
94 DLG2_3 0.0000000002 7.813308929582946e-09 / 1.6547061876174137e-09 / 1.3841014381780992e-08 / 3.911794473620475e-08 / 3.925563562928499e-06 / 1.0025262671531361e-05 / 1.4592559377242048e-06 / 7.203525855071736e-08 5.333355940483967e-07 / 2.493514693804668e-05 / 1.3553742801395556e-05 / 2.784723823441103e-05 / 0.00031844709703193725 / 3.540970687955017e-05 / 4.292537092544752e-05 / 4.4176636548796324e-05 1.94307E-06 8
95 PPP1R1A_2 0.0000000058 6.21390552863653e-07 / 6.893999398193879e-07 / 7.492219023207615e-07 / 2.702881264505673e-05 / 3.680752556412065e-06 / 1.6060512405884523e-05 / 7.73108993011784e-06 / 6.419532166056714e-06 2.1597799174876656e-06 / 1.9305294911280603e-06 / 5.352949078223872e-06 / 6.799175330608916e-06 / 8.452688032747793e-06 / 1.5945569790774137e-05 / 3.22477346098806e-05 / 2.984896137178954e-05 7.87259E-06 8
96 EFNB1_1 0.0000000276 2.7109747094287326e-07 / 6.979794879972793e-06 / 9.224071980226081e-07 / 4.0242980256377906e-05 / 3.2501044823812903e-07 / 0.0004073113752386311 / 5.2109649171464235e-06 / 4.559947241482223e-05 2.1957511801277782e-07 / 4.889428996554765e-08 / 2.1248474074975664e-07 / 1.7135370925414656e-07 / 3.884450294793579e-06 / 5.591633483860606e-06 / 1.8857958946421756e-06 / 2.8107942340015973e-05 6.33579E-05 8
97 POU3F1_2 0.0000000002 1.0829140297466289e-09 / 2.140496501618477e-08 / 0.0006617980305097352 / 3.539399887995572e-05 / 1.1605014260398891e-06 / 4.1398213999064624e-06 / 4.864296167501907e-07 / 1.3483681400210042e-06 6.030358521257982e-09 / 1.7387409176294374e-08 / 5.254390767028075e-06 / 2.543218750177778e-06 / 1.6396573544351217e-06 / 8.529464444824402e-07 / 6.695092024209846e-06 / 8.770352824154869e-06 8.80437E-05 8
98 JPH1_2 0.0000000087 5.556780192800504e-08 / 2.0874526624748995e-06 / 0.0012644399858917665 / 4.607960729596523e-06 / 2.1738520362230936e-05 / 1.6503521660931074e-06 / 2.1738520362230936e-05 / 0.00015574282021503215 3.4277179006258406e-08 / 1.490529071824182e-08 / 3.286947652963165e-05 / 8.194195146930721e-06 / 2.1888678883833245e-05 / 2.6787516426543844e-06 / 1.2909385190385643e-05 / 1.5296407537085686e-05 0.000184008 8
99 LGALS3_5 0.0000000000 0.0003565042040229888 / 9.438944028750308e-06 / 9.04485841302387e-07 / 1.6632151970584391e-06 / 3.410158051548764e-05 / 0.0003318801877935931 / 0.0012804486516771864 / 0.00021733046754869307 6.677920897376901e-06 / 2.6764509283677262e-06 / 1.8682268381796687e-06 / 7.156112560189961e-06 / 5.102936564089435e-05 / 1.756292794705785e-05 / 9.025855388190028e-05 / 1.637569955003e-05 0.000279034 8
100 LRRC4B_1 0.0000002709 1.887107728600381e-05 / 0.0005437871552770366 / 0.0001432193232982916 / 0.00011602560329098725 / 0.00021988598115354305 / 0.0007228851823325908 / 0.002087197919276702 / 0.0004963923899259765 5.474742848216316e-08 / 7.540000372679234e-08 / 2.4324836459725464e-07 / 1.1863961735006869e-06 / 1.582805196129757e-06 / 3.4634781029298443e-06 / 3.0574198226347985e-06 / 7.803003903662519e-07 0.000543533 8
101 ARHGAP19_1 0.0000004900 1.1263759452799203e-06 / 0.0002944288613709527 / 2.051237402337122e-05 / 0.00014547367344876742 / 0.0003301911422383287 / 0.0001395680222164631 / 0.0026702661426604127 / 0.006072266622156599 8.088262923201297e-10 / 5.32512126526287e-09 / 8.298236021731966e-08 / 3.5084952233067013e-07 / 2.3265577637109093e-06 / 1.1001720936904985e-06 / 3.6392711556668255e-06 / 1.2562017250662189e-06 0.001209229 8
102 MYL9_1 0.0000000778 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.7109747094287326e-07 / 1.3062838211579366e-05 / 9.289397717877934e-06 / 5.2109649171464235e-06 / 3.2501044823812903e-07 2.459173869598607e-06 / 3.652101302901246e-06 / 1.2972527217084128e-05 / 8.597378090854104e-06 / 5.7833188092788925e-06 / 1.4022276300344631e-05 / 2.145854408813797e-06 4.89895E-06 7
103 TMEM170B_1 0.0000002606 9.289397717877934e-06 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 2.0071481202007584e-05 / 4.559947241482223e-05 / 2.408755304649635e-05 / 5.2109649171464235e-06 1.9697921819906958e-07 / 3.165978824218861e-07 / 2.2816438659720932e-06 / 2.742836199391347e-06 / 6.990510977409468e-05 / 2.9323575212698406e-06 / 8.993575247920803e-05 1.50723E-05 7
104 CSAD_1 0.0000002822 5.2109649171464235e-06 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.54688199707126e-05 / 2.0071481202007584e-05 / 6.979794879972793e-06 6.111203426085803e-07 / 2.171879517260808e-06 / 5.854820901741727e-07 / 7.835058995288738e-07 / 2.7557290434491165e-06 / 6.817652862377265e-07 / 1.2092985656812561e-05 1.62017E-05 7
105 ASGR1_5 0.0000000000 1.1623489088470996e-07 / 3.721066145469274e-07 / 3.333239304736607e-06 / 2.1608013080506192e-07 / 3.230485829869497e-05 / 8.060189282236343e-06 / 8.676969132083257e-05 7.305647078744524e-09 / 5.144455443656822e-07 / 1.4357703259269896e-06 / 1.2509260043210937e-08 / 5.934720152286974e-06 / 2.2212849303091722e-05 / 1.856219255522198e-05 1.87389E-05 7
106 KIAA1958_1 0.0000014113 9.224071980226081e-07 / 3.2501044823812903e-07 / 9.289397717877934e-06 / 2.0071481202007584e-05 / 0.00029640089162746337 / 1.3062838211579366e-05 / 2.408755304649635e-05 1.7837147826607992e-06 / 6.377999497501375e-07 / 6.986597395696305e-07 / 2.0980658004722796e-06 / 1.9921322770288805e-06 / 1.773331235256366e-05 / 5.3250557763788615e-06 5.20228E-05 7
107 NPW_2 0.0000000041 3.24920563754477e-05 / 1.6676618048371524e-06 / 3.349324237754571e-06 / 0.00026033133118006545 / 2.8198901661861037e-07 / 1.3377106429420062e-05 / 0.00015487870247863725 1.1216334102038042e-05 / 3.795870398901593e-05 / 2.789700527592356e-05 / 2.4370350557859375e-05 / 2.383281576252229e-06 / 1.739637519533283e-05 / 4.995051896804675e-05 6.66255E-05 7
108 CAP1_1 0.0000001084 3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 5.1570472200670454e-05 / 0.0006813940301036226 / 1.615375160694009e-05 2.3269670797546372e-09 / 2.178989287248064e-07 / 1.5690808649462252e-07 / 2.2812382420261574e-07 / 5.003267757352306e-07 / 5.854077230406485e-06 / 3.5713716118086355e-06 0.000111963 7
109 SIAH3_1 0.0000003288 2.7109747094287326e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 3.2501044823812903e-07 / 1.615375160694009e-05 / 0.0019333915490623197 6.049342679130285e-07 / 8.815712638887937e-06 / 4.740549194395327e-06 / 9.480468782335477e-06 / 1.5820053502878103e-05 / 6.463404069739772e-06 / 1.6126637325555423e-05 0.000283492 7
110 PALM3_1 0.0000000299 1.1263759452799203e-06 / 0.00014547367344876742 / 0.0002944288613709527 / 6.267778266652492e-05 / 0.00036105139567184824 / 4.369070707050029e-05 / 0.0012393227037226365 1.61127559567575e-08 / 5.017834401276047e-07 / 3.661929862620404e-06 / 1.2173443563611742e-05 / 1.1966193354414176e-05 / 2.4195118600922182e-05 / 1.7243254719929916e-05 0.000306824 7
111 STMN3_1 0.0000000026 7.246316173948605e-05 / 3.547654313435299e-05 / 0.0009373528710364089 / 0.0006480090460888989 / 0.0006480090460888989 / 0.0006480090460888989 / 0.0003279301515605841 7.322406775875832e-06 / 8.942892958849265e-06 / 1.807142776332772e-05 / 2.509219654843992e-05 / 1.8505484636417077e-05 / 3.37731892462157e-05 / 9.285668025091915e-06 0.000473893 7
112 TMEM81_1 0.0000008765 5.273896379563962e-05 / 6.356656086987109e-05 / 0.00043134694416039135 / 0.00013546030217733798 / 0.0004059772887267331 / 0.0023391751758116753 / 0.00032373731095170963 1.0787679920477812e-07 / 2.5789707372412023e-07 / 2.2840059569727543e-06 / 3.5876629179259e-06 / 1.224552952677817e-05 / 1.3699807790719473e-05 / 0.00010021610177229421 0.000536 7
113 SPATA6L_2 0.0000000000 6.561438181488045e-08 / 0.0039060792371246288 / 1.2713340125393577e-06 / 4.9709559427158936e-05 / 2.9984630262222775e-05 / 2.5044323053359897e-05 / 0.0003189222745634422 1.1928730580085498e-07 / 1.6308994378745635e-05 / 7.252465307108788e-07 / 4.675129100784084e-05 / 2.4918595616148034e-05 / 1.2527391630040111e-05 / 0.00035139543234848433 0.000618725 7
114 CSRP2BP_5 0.0000000001 0.0010693215114176687 / 0.0005366621924321155 / 5.114637961482107e-05 / 0.001965268902490897 / 0.0006502221049801445 / 1.6105294963590637e-05 / 0.0010730574005743563 3.1276785123692046e-07 / 9.71112422824034e-07 / 6.485117187559721e-06 / 9.024033737327827e-06 / 2.832326930093088e-06 / 4.687104252350739e-07 / 1.9659786069911358e-05 0.000765969 7
115 MAP2K6_1 0.0000003962 0.00049387566368266 / 0.001914379403049941 / 0.0025176594807100345 / 0.0006315592529035093 / 0.0034656404808317003 / 0.00043106377145357623 / 0.004971246918927329 1.1930754029013138e-06 / 8.239304675009157e-06 / 9.456559403963851e-07 / 1.224552952677817e-05 / 1.1431401687645685e-05 / 4.3734040668837504e-05 / 2.2586038013431965e-05 0.002060775 7
116 HOXB13_1 0.0000005163 3.2501044823812903e-07 / 0.011066537502725836 / 9.289397717877934e-06 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 0.017443989828652796 / 1.615375160694009e-05 2.2857725793381497e-08 / 6.58231193542836e-07 / 9.335221622816497e-07 / 5.9574734192841e-07 / 9.009609250490209e-07 / 6.752637204404786e-06 / 6.717516905544411e-06 0.004079613 7
117 RBM12B_1 0.0000027010 0.04720120118838744 / 0.01326934306028551 / 0.016928162681653376 / 0.031078733529297287 / 0.002048221708938053 / 0.0034110277620841853 / 0.0010661050941684071 2.1680661197087e-06 / 2.9189015908569146e-07 / 1.1699094105987198e-06 / 7.252465307108788e-07 / 7.978099824844419e-07 / 9.884000914674844e-06 / 2.094766018419809e-07 0.016428971 7
118 ADRB3_1 0.0000000110 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 9.224071980226081e-07 4.241171654391019e-07 / 1.460759694934436e-06 / 1.0275041110630902e-05 / 2.951788675228993e-05 / 2.7256307870565235e-06 / 1.7536333634491446e-06 5.3003E-06 6
119 LUC7L_5 0.0000000000 4.893976636572636e-08 / 4.301553480101108e-06 / 1.9454781373606418e-07 / 2.401972521996653e-06 / 2.7416809858149543e-05 / 2.126445195983224e-06 9.243344747900569e-10 / 5.575865427598105e-07 / 7.332853758502689e-07 / 1.804034226196658e-06 / 3.3436666464536245e-05 / 5.494452455047808e-06 6.08171E-06 6
120 ITM2A_1 0.0000000846 2.7109747094287326e-07 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 / 4.0242980256377906e-05 9.57143021581257e-08 / 2.3530982511650296e-08 / 9.277238538824435e-08 / 9.772375417317643e-08 / 7.542510909686565e-07 / 5.344419818471506e-07 8.99204E-06 6
121 ICAM4_1 0.0000001503 3.2501044823812903e-07 / 9.289397717877934e-06 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 3.1219185299958266e-05 / 2.7109747094287326e-07 6.095674277276536e-08 / 1.9332727891019487e-07 / 1.5381709053459223e-06 / 2.6680204178603233e-06 / 3.8772692803359075e-06 / 2.7997676176494448e-05 1.03498E-05 6
122 HMCN1_1 0.0000002057 9.224071980226081e-07 / 6.979794879972793e-06 / 3.2501044823812903e-07 / 2.0071481202007584e-05 / 3.54688199707126e-05 / 2.7109747094287326e-07 2.325888657256971e-08 / 7.057956530849985e-08 / 4.408357829435433e-07 / 3.236174072045171e-07 / 2.3836720647269927e-06 / 1.2257808319403609e-05 1.06731E-05 6
123 ZNF397_4 0.0000000000 1.1490697075516314e-07 / 5.267608369882088e-05 / 2.6997110563148354e-05 / 1.1548564870533097e-06 / 2.0333256661723552e-08 / 5.997442187105882e-06 1.209273134002773e-07 / 2.356993671060887e-07 / 1.889438601616299e-06 / 4.5197938838389625e-07 / 1.0616232919691243e-07 / 1.1196923674745125e-06 1.44935E-05 6
124 DRAP1_1 0.0000000328 2.408755304649635e-05 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 5.1570472200670454e-05 1.8161954541326127e-08 / 2.3467711706414707e-08 / 7.39840605537318e-08 / 9.681901028699171e-08 / 6.251568155356543e-07 / 7.07965550831983e-07 1.77111E-05 6
125 DTX3L_1 0.0000000920 2.408755304649635e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 3.54688199707126e-05 / 5.1570472200670454e-05 3.2169896739895314e-07 / 6.548683737212715e-07 / 1.9632962963789034e-07 / 8.23683137309925e-07 / 1.3384906301502949e-06 / 3.688500356447034e-06 2.02773E-05 6
126 NUDT11_5 0.0000000000 2.520077460838455e-06 / 0.00019847043212428944 / 9.212731853638905e-06 / 5.327685852957849e-05 / 7.074807022331135e-06 / 5.506319326881712e-06 6.030864046314226e-07 / 5.4148978375789446e-05 / 4.298503068923771e-06 / 4.6387467002391374e-07 / 3.113591613373381e-06 / 2.237597740187554e-06 4.60102E-05 6
127 ADAM19_3 0.0000000000 0.00014925747204187325 / 2.926784989427661e-05 / 3.9436377050004215e-05 / 8.350382499334708e-05 / 9.099838750221392e-06 / 0.00012689846158790022 4.429367557026339e-06 / 3.859292848839367e-07 / 7.371158036631407e-06 / 3.558113101675235e-06 / 1.737907854441337e-05 / 1.0224109644328716e-05 7.29106E-05 6
128 HS3ST4_2 0.0000000267 4.981322036893917e-06 / 2.606975599460185e-05 / 8.565659227788306e-05 / 0.0002754556536102276 / 7.209835341373319e-05 / 3.152964683173717e-05 1.1012098448593559e-06 / 1.1675757440124896e-05 / 1.5407255327564443e-05 / 1.049514284917264e-05 / 1.031858123131195e-05 / 0.0001438654836752122 8.26319E-05 6
129 CRIPAK_4 0.0000000000 0.00015414987039053912 / 0.00011823367623626102 / 0.0009189200604961089 / 0.0007149452063580587 / 0.0006845676304155839 / 0.00041005648424125555 2.245806750816546e-06 / 4.7163754949833893e-07 / 2.309187383213676e-06 / 1.0481115140245655e-05 / 1.5648091897413959e-06 / 2.123855035553147e-06 0.000500145 6
130 OLFM3_1 0.0000002915 1.1263759452799203e-06 / 9.971939174478468e-05 / 2.051237402337122e-05 / 0.0001395680222164631 / 0.0028963504457353837 / 7.924407878618111e-05 2.6837870218219574e-09 / 3.561518617190357e-08 / 1.882754136330223e-07 / 1.470434762035522e-07 / 3.069489887698277e-07 / 4.200340993458125e-06 0.00053942 6
131 LMO2_4 0.0000000000 1.3505056742555753e-05 / 1.1618150079504721e-07 / 0.00013064212236741545 / 4.111357296377365e-06 / 0.0035192650416157674 / 4.781143220313644e-05 2.1639192493163854e-06 / 1.7833831305356847e-07 / 2.620411019163743e-06 / 2.1101434315006795e-06 / 2.7275081013397453e-05 / 1.3040674962690977e-06 0.000619242 6
132 SALL2_1 0.0000003934 1.1263759452799203e-06 / 0.0038265104822853674 / 2.051237402337122e-05 / 0.0002944288613709527 / 0.0008581803853921776 / 0.00014547367344876742 1.6243939304465606e-09 / 9.280889011804578e-07 / 7.466764406748627e-07 / 6.300687009130246e-07 / 1.0493357935620423e-05 / 9.50907155614804e-07 0.000857705 6
133 SLC35F3_1 0.0000002146 0.0008619727380490119 / 0.004410274724633273 / 8.807499017205126e-05 / 0.0007073001228128905 / 1.228676574562544e-05 / 0.002107325343692074 4.661997914978101e-07 / 8.34478701501445e-07 / 8.627333575428783e-07 / 1.0961759232568219e-05 / 1.5605455965805294e-06 / 4.962489165357357e-06 0.001364539 6
134 RHOH_1 0.0000001993 1.887107728600381e-05 / 0.0001432193232982916 / 0.0002441254991542676 / 0.0020865035640383737 / 0.006227948945630897 / 0.00021988598115354305 8.908782275302052e-08 / 1.3002938709565544e-06 / 8.336014361253352e-07 / 1.0527458641807459e-06 / 1.1820153415714242e-05 / 2.4865375915662647e-06 0.001490092 6
135 MED23_1 0.0000009756 0.0007073001228128905 / 0.0011323441860117745 / 0.004410274724633273 / 0.0010325370165401593 / 0.002107325343692074 / 0.0016226906289916678 1.0975653631511024e-07 / 1.045969028083387e-07 / 6.416985820926155e-07 / 1.5558825628623162e-06 / 8.122287757832368e-07 / 1.1607897314120871e-06 0.001835412 6
136 ALS2CR8_2 0.0000000009 0.0006315082871911089 / 0.0005431426189626602 / 0.0021396275484352 / 0.026018702566094058 / 0.001000241728120363 / 0.0003308344387923977 1.2953287867816182e-06 / 3.495208827896601e-06 / 1.6445250431991489e-06 / 2.13746074336515e-05 / 1.4749418379777713e-06 / 1.7906341936525482e-06 0.005110676 6
137 PDS5B_1 0.0000000930 0.009896861713608592 / 0.020827775351599746 / 0.0012471395414138215 / 0.0017014302658606788 / 0.0353590157796084 / 0.0012471395414138215 3.174956286948255e-05 / 2.3820952039675057e-05 / 7.64885082423866e-07 / 5.201073420332339e-07 / 3.138162419750589e-05 / 1.8874782131634276e-06 0.011713227 6
138 POU4F1_1 0.0000343460 0.009505749235636515 / 0.01380503352362386 / 0.006032512595643146 / 0.016514991038692903 / 0.03991486389987273 / 0.023304012767638813 1.736820199971154e-08 / 1.0181132930253954e-06 / 0.00018045749659898887 / 7.716585431260322e-06 / 5.0799933930760124e-06 / 2.2950455177001124e-05 0.018179527 6
139 LINGO1_4 0.0000000000 1.7973910992848286e-09 / 3.2068838263254377e-07 / 5.436354594228244e-06 / 9.44534744977059e-08 / 8.340191540542289e-07 4.250081788501893e-07 / 3.2784019242777824e-06 / 9.246191514674586e-06 / 6.77126904336827e-07 / 1.2203319241697544e-05 1.33746E-06 5
140 EZH2_2 0.0000000004 2.2402150648537843e-08 / 1.471749614726362e-06 / 3.983245164121986e-08 / 8.584401402568793e-06 / 2.135362618124217e-07 7.330469554133431e-08 / 6.45181252176691e-06 / 2.8233957548442e-07 / 1.386977654368529e-06 / 3.4840585402585815e-07 2.06638E-06 5
141 ZNF786_5 0.0000000000 0.00011773904137664178 / 1.3280032513820524e-05 / 9.576463103103271e-05 / 4.4014899917305675e-06 / 8.430577899747024e-06 2.140329000239017e-05 / 7.930355204992489e-07 / 4.145669385412816e-06 / 9.512787508368679e-07 / 2.434604498224823e-06 4.79232E-05 5
142 SLCO5A1_1 0.0000008012 3.2501044823812903e-07 / 9.224071980226081e-07 / 0.0003167991900078877 / 2.408755304649635e-05 / 9.289397717877934e-06 3.0174324318950897e-07 / 9.418668072896726e-07 / 1.6676348515768935e-05 / 3.957834622626353e-06 / 6.700293161768197e-06 7.02847E-05 5
143 DKK2_1 0.0000006927 9.224071980226081e-07 / 2.7109747094287326e-07 / 3.2501044823812903e-07 / 0.0004073113752386311 / 9.289397717877934e-06 6.460209020485614e-08 / 3.59230415078595e-07 / 1.0312698979503442e-06 / 1.4199406561075603e-05 / 5.457198354391937e-06 8.36239E-05 5
144 ATP11C_1 0.0000001503 2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 0.0004422271229621968 / 5.2109649171464235e-06 1.9332727891019487e-07 / 1.36409072963545e-08 / 3.1896874375468994e-07 / 4.81561728868056e-06 / 8.990145137526255e-07 9.11223E-05 5
145 KMO_1 0.0000001461 1.887107728600381e-05 / 0.0001432193232982916 / 0.0005437871552770366 / 0.00021988598115354305 / 0.0002441254991542676 2.485807963409032e-07 / 1.1240339046572947e-06 / 3.782902556894412e-07 / 4.67845142282578e-06 / 3.603323688705048e-06 0.000233978 5
146 SPOCD1_1 0.0000000083 3.2501044823812903e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 0.0019333915490623197 / 1.615375160694009e-05 7.818277659920641e-08 / 5.795083345677293e-07 / 4.4221671271015996e-06 / 9.908657729834685e-06 / 1.2284458405143113e-05 0.000394173 5
147 LMO3_1 0.0000005163 2.0071481202007584e-05 / 9.224071980226081e-07 / 0.00029640089162746337 / 6.979794879972793e-06 / 0.005510243055764825 2.8303059659858582e-08 / 1.2770021336022465e-07 / 1.8886612700849868e-06 / 1.5048748666061165e-06 / 9.979708008853078e-07 0.001166924 5
148 SUCLG2_1 0.0000006277 0.0012538224517635887 / 0.00030020193073310375 / 0.001142443802029975 / 0.0015995521116198169 / 0.0025493281320611745 6.010018117118236e-09 / 1.4873864874902438e-08 / 2.812059954690805e-06 / 4.5297727245223865e-07 / 1.0136268892104269e-06 0.00136907 5
149 CDC42EP3_1 0.0000005053 0.00015668136762185704 / 0.0017937623479293012 / 0.00014067446309259184 / 0.0006379488254521119 / 0.0054623966213403945 4.0545605557306084e-07 / 2.0579987707958014e-06 / 6.648866334116203e-06 / 6.110689397168396e-05 / 5.05967411068452e-06 0.001638293 5
150 VIM_2 0.0000150468 0.001194606450859983 / 0.00022458373669886374 / 0.00019944988446973612 / 0.006523673737606515 / 0.0004302878134597533 3.450494605886152e-11 / 2.904281074975244e-11 / 4.5432513762116924e-07 / 4.7610232918156417e-07 / 3.936782111680953e-06 0.00171452 5
151 KIAA1456_5 0.0000000000 3.392135383479947e-09 / 1.6065108187886577e-09 / 9.157017996950809e-07 / 3.6928231492352363e-07 5.371804546576567e-07 / 8.674274096479547e-08 / 5.026970587223131e-06 / 3.9399829491464125e-06 3.22496E-07 4
152 ATP1A1_1 0.0000003288 2.7109747094287326e-07 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 4.379090848715678e-06 / 3.77167172557141e-06 / 3.5551496515817035e-06 / 8.53191167142631e-06 2.12458E-06 4
153 EFHD2_3 0.0000000000 2.621657181978166e-09 / 5.054801258373376e-07 / 9.68006271762989e-06 / 1.8365412363165977e-07 8.572257412643892e-07 / 1.794103459804273e-06 / 9.95075608052033e-06 / 1.2610525065949156e-05 2.59295E-06 4
154 NPY1R_1 0.0000000555 3.2501044823812903e-07 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 9.224071980226081e-07 3.314259306506593e-07 / 3.2811589034439775e-06 / 2.0319189662380453e-05 / 4.769447269863606e-06 2.70198E-06 4
155 PTPN13_1 0.0000002820 2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 2.6783272230077516e-07 / 1.895295482848707e-08 / 1.8806480924583324e-07 / 9.335221622816497e-07 3.34607E-06 4
156 SOX11_3 0.0000000001 1.2099644991608733e-05 / 2.0089868169610723e-07 / 1.0776466574906309e-07 / 4.755876859816789e-06 7.955105981028123e-06 / 1.0121247355306893e-06 / 3.4448329577362182e-06 / 1.4342875182087443e-05 4.29105E-06 4
157 RAVER2_1 0.0000000192 3.2501044823812903e-07 / 9.289397717877934e-06 / 9.224071980226081e-07 / 1.3062838211579366e-05 3.105760909035132e-07 / 7.687495446941115e-07 / 1.1986592733451634e-06 / 9.900405822480467e-06 5.89991E-06 4
158 CD44_3 0.0000000000 7.172707428277077e-07 / 4.481007438950932e-07 / 8.746535299915613e-07 / 2.5220058311922642e-05 1.7230525778249127e-07 / 2.754399275478179e-07 / 5.399255839823898e-06 / 5.404432984233412e-06 6.81502E-06 4
159 WIPI1_1 0.0000000779 3.2501044823812903e-07 / 4.559947241482223e-05 / 9.224071980226081e-07 / 2.408755304649635e-05 2.847754855927293e-07 / 5.356440974504928e-05 / 3.583982029691469e-06 / 9.40961708804259e-06 1.77336E-05 4
160 MEIG1_1 0.0000021159 2.768256422538597e-05 / 9.531965824595176e-05 / 3.738602753166595e-05 / 7.050646137918624e-07 3.8552589093989376e-07 / 5.403268031058945e-06 / 1.875181574291302e-06 / 3.691562617026471e-06 4.02733E-05 4
161 ITGAV_1 0.0000043137 5.198191671140737e-06 / 2.078130544858706e-05 / 8.173042888768766e-05 / 6.124458953230731e-05 2.675335342140057e-08 / 5.91155167762294e-06 / 3.175137319143903e-07 / 1.4088412652065131e-05 4.22386E-05 4
162 WASF1_2 0.0000000139 1.249810740543092e-06 / 4.033558519530211e-05 / 1.5172365718941338e-06 / 0.00016701924649532873 4.465170531049283e-08 / 7.347798043454918e-07 / 3.12571392342915e-07 / 2.1882250573351623e-06 5.25305E-05 4
163 SEPT5_1 0.0000000779 3.2501044823812903e-07 / 9.224071980226081e-07 / 0.0003167991900078877 / 2.0071481202007584e-05 4.6698972944525575e-06 / 2.50941550434497e-06 / 7.4466622077249586e-06 / 4.094296941956349e-06 8.45295E-05 4
164 ZNF703_4 0.0000000000 2.212311553111884e-06 / 7.684875066256022e-06 / 1.6293260278199978e-05 / 0.0008381727818825804 3.314259306506593e-07 / 7.977471601458215e-07 / 1.8053474935255696e-05 / 2.523320003794371e-06 0.000216091 4
165 RCAN1_1 0.0000004561 2.051237402337122e-05 / 0.0008581803853921776 / 1.1263759452799203e-06 / 0.00014547367344876742 1.151531177459646e-07 / 1.639867245393111e-05 / 1.1127380583214237e-07 / 3.9475777725155106e-07 0.000256323 4
166 MEIS1_1 0.0000004303 0.0001249119186090808 / 0.001757554115983901 / 2.051237402337122e-05 / 0.000326206047495105 2.6783272230077516e-07 / 3.936737849973941e-06 / 1.6694305968259358e-06 / 7.365498385123174e-06 0.000557296 4
167 DOCK9_2 0.0000000000 4.145085061135413e-05 / 3.702123384814164e-05 / 0.0003340879256796464 / 0.001986982649747413 2.7146173079304695e-06 / 2.6989667147770683e-07 / 5.081672826189643e-05 / 3.9279153945945585e-05 0.000599886 4
168 MAP2K1_1 0.0000000599 0.0007934067413946306 / 0.001424661642376461 / 0.0001432193232982916 / 0.0001432193232982916 6.397852510979244e-07 / 1.229050427171932e-05 / 4.600454084913176e-07 / 1.216134119529828e-07 0.000626127 4
169 BAZ2A_1 0.0000087909 0.0006400860846326889 / 0.00019507867134893112 / 0.0005646566395776797 / 0.0011256461353458978 3.4543484518327023e-07 / 2.666805309562172e-06 / 5.506146432831658e-07 / 2.9358775945182435e-06 0.000631367 4
170 TMEM70_2 0.0000000042 0.000803532445292482 / 3.592934798967807e-05 / 2.0485173730412846e-05 / 0.002205124341612829 2.2344846667733606e-07 / 1.07351128025269e-06 / 3.1896874375468994e-07 / 3.0408081748624807e-06 0.000766268 4
171 CSRP3_1 0.0000008027 0.0018449614599039168 / 0.00038686777181974065 / 0.00048368218865146016 / 0.001675382961010776 2.60376611739122e-06 / 2.102391157291273e-06 / 2.004512392075139e-06 / 1.2729780600591483e-06 0.001097724 4
172 MSRB3_1 0.0000003307 2.1638869199653735e-05 / 0.0029815335281472605 / 0.0005737747064104953 / 0.007382285536659921 1.4806435472894142e-06 / 1.0110256424760308e-06 / 3.5361568488813283e-06 / 8.63235449098127e-05 0.002739808 4
173 PTGER2_1 0.0000002152 0.00269524080408226 / 0.007101048391336863 / 0.00668150271306391 / 7.915379277260866e-05 3.584070271555361e-09 / 1.3436997812686243e-07 / 1.3606501871455058e-06 / 1.1858761514818132e-06 0.004139236 4
174 ARHGAP44_2 0.0000005305 0.001389487072786441 / 3.911112061086556e-05 / 0.0072669444150837495 / 0.032560551569980084 1.5851926645157727e-06 / 5.333355940483967e-07 / 4.1196587397566423e-07 / 1.9907111943687763e-05 0.010314024 4
175 TTC7A_2 0.0000431038 0.0034136112166290996 / 0.019663495986739683 / 0.015108389305698126 / 0.023304012767638813 1.9331908145550604e-07 / 2.9725508005745186e-07 / 6.456589638188038e-07 / 1.1620049901469098e-06 0.015372377 4
176 SLC35F1_1 0.0000000393 9.224071980226081e-07 / 3.2501044823812903e-07 / 2.7109747094287326e-07 2.910892954811522e-06 / 2.427468480432927e-06 / 1.497883668566738e-05 5.06172E-07 3
177 KRT25_4 0.0000000910 1.8022657475902624e-06 / 3.876432302949376e-08 / 9.243212121314035e-07 8.698985549478663e-06 / 1.3122203018407308e-05 / 2.3955519604051558e-05 9.21784E-07 3
178 PAX7_1 0.0000004451 3.2501044823812903e-07 / 9.224071980226081e-07 / 5.2109649171464235e-06 2.237597740187554e-06 / 4.6661224912755335e-06 / 6.814494589515358e-05 2.15279E-06 3
179 ENC1_1 0.0000002820 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 1.9120440072426562e-07 / 4.6661224912755335e-06 / 2.0866430814653658e-06 2.7424E-06 3
180 ERO1L_3 0.0000000002 4.539445950022412e-06 / 2.5790650047618876e-07 / 3.931265767356836e-06 8.753743400501336e-05 / 2.307172538255043e-06 / 0.0001811706174672882 2.90954E-06 3
181 KANSL2_2 0.0000000036 5.454092964102538e-06 / 2.0483330180932313e-06 / 1.3610927050562742e-06 1.3993846023737915e-07 / 4.67736331535542e-05 / 3.809175259493249e-06 2.95451E-06 3
182 RPN1_3 0.0000000004 8.225833660011401e-07 / 8.696575941061198e-06 / 2.1691780926743226e-07 2.5845817998249264e-07 / 2.15788202970697e-06 / 7.928931114532352e-06 3.24536E-06 3
183 PTGER3_2 0.0000000653 6.627915836434039e-07 / 2.668064610627935e-06 / 6.6526771052306895e-06 4.987581945086968e-07 / 6.416985820926155e-07 / 1.042398266072424e-06 3.32784E-06 3
184 CACHD1_2 0.0000000001 6.841823795764238e-06 / 1.1611327091078624e-06 / 3.757056495538064e-06 6.036905353459894e-07 / 1.7240231306506295e-06 / 2.495170691986825e-05 3.92E-06 3
185 VPS37D_2 0.0000000001 8.999654334938381e-06 / 3.0621601602130305e-06 / 2.72061163246224e-07 5.620700861394285e-07 / 1.1802005266016428e-06 / 1.1362044976111473e-06 4.11129E-06 3
186 ZDHHC17_1 0.0000000110 1.3062838211579366e-05 / 9.289397717877934e-06 / 3.2501044823812903e-07 1.9472709844203468e-07 / 8.64813860440053e-09 / 4.08973006429415e-08 7.55908E-06 3
187 TMEM9B_2 0.0000000138 1.0001419899907697e-05 / 2.088214452889034e-05 / 3.1085970554200676e-07 7.663345318857788e-08 / 9.904773066152364e-07 / 1.645825440209025e-06 1.03981E-05 3
188 HOXD10_1 0.0000000921 2.7109747094287326e-07 / 3.1219185299958266e-05 / 9.224071980226081e-07 2.565463018954012e-06 / 1.941433683772925e-06 / 4.178051372181341e-06 1.08042E-05 3
189 ITFG2_1 0.0000005163 4.559947241482223e-05 / 2.0071481202007584e-05 / 5.2109649171464235e-06 3.439076468267492e-06 / 5.9260015900657735e-06 / 5.4469810926531135e-05 2.36273E-05 3
190 EGFL7_1 0.0000000299 1.1263759452799203e-06 / 4.369070707050029e-05 / 0.00018252021476464813 1.8700341255096223e-09 / 5.293074654152259e-06 / 1.2852959762944565e-05 7.57791E-05 3
191 PPP2R2A_5 0.0000000000 2.3018920608566846e-05 / 2.515879541149387e-06 / 0.00026563530537353084 2.892554421707878e-06 / 2.79139624836141e-06 / 0.0002549462415116326 9.70567E-05 3
192 BRF2_2 0.0000000001 9.751314166241359e-06 / 0.0003129016625892748 / 0.00016417889880625215 3.759229641754634e-08 / 2.1837529883578724e-05 / 1.5455954512499827e-06 0.000162277 3
193 ATP1B2_1 0.0000007792 8.350565572888588e-05 / 0.0003022930393277112 / 0.00012034822430170891 4.9185008634943495e-06 / 1.749159859965176e-05 / 1.758385056892761e-05 0.000168716 3
194 PTGES3_2 0.0000000002 0.00028889915694293186 / 0.0004343373075467472 / 2.3874708929429098e-06 6.3806928808699615e-06 / 3.6976674058849736e-07 / 2.590931905512812e-06 0.000241875 3
195 NR0B1_2 0.0000000017 0.00095500393558891 / 4.835640776889601e-06 / 1.3401582342156554e-08 0.00012317884029827643 / 9.41313565329906e-05 / 1.946170412794958e-05 0.000319951 3
196 GALNT10_2 0.0000073319 0.001194606450859983 / 0.00022458373669886374 / 0.00019944988446973612 4.2967502063254294e-08 / 2.7580106394921852e-08 / 1.6050811528160658e-07 0.000539547 3
197 TMEM229A_1 0.0000019763 1.1263759452799203e-06 / 0.0017875715263402634 / 2.051237402337122e-05 4.470056894883235e-08 / 3.212400793996756e-05 / 3.0330851096686316e-06 0.00060307 3
198 NCEH1_1 0.0000021880 0.0025176594807100345 / 2.9249667673039124e-05 / 0.00049387566368266 2.9852999237846436e-07 / 3.6664065520662378e-06 / 1.4296784245243089e-06 0.001013595 3
199 C1orf27_1 0.0000005347 2.4400796134349794e-05 / 0.00048683461556788134 / 0.004468346085026116 3.3728825978612466e-08 / 1.7773181504273556e-05 / 1.1552987857913018e-05 0.00165986 3
200 TMEM14C_1 0.0000014171 0.00013494197652300576 / 0.008044269920970437 / 0.00043124882395994033 1.4472691259712559e-07 / 6.268977803019969e-07 / 2.4350896869975287e-07 0.002870154 3
201 DKK3_1 0.0000003462 0.0013248126277991738 / 0.0010602701525608943 / 0.008185982685681903 1.5846200021034092e-07 / 9.094647997910571e-07 / 1.069596462403796e-05 0.003523688 3
202 LRRC4C_1 0.0000000007 0.001612584660708291 / 0.008357898545557461 / 0.004641723683002966 5.839066787020226e-06 / 8.030484942525321e-05 / 2.874321825060119e-06 0.004870736 3
203 HOXD9_1 0.0000001816 0.003521766194763358 / 0.009358203838825317 / 0.006565901152596447 8.908782275302052e-08 / 1.4262192253107675e-06 / 1.1653976873204907e-05 0.006481957 3
204 SLC5A6_2 0.0000083594 0.00329856915210616 / 0.016629670900162985 / 0.003718378687262143 3.9237422990064166e-08 / 2.1675313933802943e-06 / 3.4461744463603383e-07 0.007882206 3
205 LYPD1_1 0.0039884477 0.00561851618326168 / 0.010298037138015295 / 0.011465748499709204 0.00012364715000227235 / 7.610927192464296e-06 / 3.436634759679429e-05 0.009127434 3
206 CIB1_1 0.0000012582 2.4400796134349794e-05 / 0.025949952318682364 / 0.005327800743076973 6.521419935683383e-08 / 0.0001508899394071643 / 2.7037258898085093e-06 0.010434051 3
207 PDSS1_2 0.0000001438 2.087686423298029e-05 / 0.032547979119801014 / 0.0009731125399429332 9.181067152023525e-08 / 1.866363701474153e-07 / 7.882821468850854e-06 0.011180656 3
208 SHC2_1 0.0000043527 0.008666672397448167 / 0.01221055371440681 / 0.023108053632132773 3.5046868808471237e-08 / 1.4152639674778885e-07 / 1.1044438525648634e-06 0.01466176 3
209 ATP6V0B_1 0.0000652113 0.0017008783545293586 / 0.03338582426278086 / 0.022359654779542756 1.8156513888722432e-05 / 0.0006738450240411453 / 0.00015710780312305387 0.019148786 3
210 SEPSECS_1 0.0000880523 0.03187722870624648 / 0.03280798665424235 / 0.039867021959100635 2.337882197149697e-08 / 1.6555950610598878e-06 / 2.8381722284939996e-06 0.034850746 3
211 BHLHE22_2 0.0000000002 1.3401582342156554e-08 / 4.659755401849588e-08 1.3361783713514048e-06 / 9.916119753409963e-07 2.99996E-08 2
212 FOXC1_1 0.0000001081 3.2501044823812903e-07 / 9.224071980226081e-07 2.464261525645891e-06 / 8.614020001816719e-06 6.23709E-07 2
213 DMRTA1_1 0.0000001005 1.0687433356337492e-05 / 7.348784993241683e-08 1.8860719855838867e-06 / 7.505602457021459e-06 5.38046E-06 2
214 CRYBG3_2 0.0000000000 7.842763361037193e-06 / 6.517914638754384e-06 1.266977339256832e-07 / 1.1569843022665961e-05 7.18034E-06 2
215 ANKRD28_1 0.0000001762 3.2501044823812903e-07 / 2.0071481202007584e-05 2.0833362771380855e-07 / 1.1004838243302006e-06 1.01982E-05 2
216 ZNF467_3 0.0000000000 1.6294904067329883e-05 / 1.3870388730546243e-05 7.288715501245973e-07 / 2.038126089530678e-07 1.50826E-05 2
217 MCU_1 0.0000000041 4.559947241482223e-05 / 2.7109747094287326e-07 0.00014805201662727028 / 1.3235442660276658e-05 2.29353E-05 2
218 ALG6_1 0.0000000034 4.559947241482223e-05 / 9.289397717877934e-06 7.757632613398362e-05 / 1.8142742683524817e-06 2.74444E-05 2
219 DST_1 0.0000000354 1.1263759452799203e-06 / 0.00018252021476464813 2.5055687616812065e-08 / 7.501693754343125e-06 9.18233E-05 2
220 CNOT6_1 0.0000000101 1.1263759452799203e-06 / 0.0002944288613709527 1.1075622702926509e-08 / 1.129572691211572e-06 0.000147778 2
221 SLC25A46_1 0.0000002913 0.00036105139567184824 / 0.00014547367344876742 2.5994147109530116e-05 / 4.968741535651153e-06 0.000253263 2
222 STRBP_3 0.0000000000 1.5669300524965997e-07 / 0.0005064725174938412 1.481967113051988e-07 / 1.3155160149040273e-05 0.000253315 2
223 SLFN11_1 0.0000000685 2.4400796134349794e-05 / 0.00048683461556788134 1.0022702721591722e-05 / 9.972925901562962e-06 0.000255618 2
224 IL1R1_1 0.0000016239 0.000617308483698201 / 6.569591094283755e-05 4.5432680388905903e-07 / 9.107588752182431e-08 0.000341502 2
225 PDE9A_2 0.0000000400 0.00041731220668757806 / 0.0005855390414154741 1.221895236718122e-05 / 4.308375284196633e-07 0.000501426 2
226 TXNDC11_1 0.0000008009 0.00037816990481376106 / 0.001675382961010776 3.35563055514752e-05 / 1.6158804956085833e-05 0.001026776 2
227 NRP1_2 0.0000038002 0.0004994794183737504 / 0.002324394606725177 5.465744973286784e-06 / 7.656204640097829e-05 0.001411937 2
228 QSER1_1 0.0000182809 0.0013570458512569155 / 0.002178697316418811 9.58284147411479e-06 / 8.84455021841255e-06 0.001767872 2
229 TNIP1_1 0.0000036678 5.198191671140737e-06 / 0.004144214246475889 6.508715673074529e-09 / 0.00019241774459470402 0.002074706 2
230 LIMS1_1 0.0000029556 0.0018263671837831345 / 0.0029439691339069544 1.6606027203704394e-06 / 2.8416546588022426e-06 0.002385168 2
231 PNISR_1 0.0000015994 0.0010325370165401593 / 0.00423890420622936 1.0714836567004093e-06 / 4.211924899648025e-05 0.002635721 2
232 MOAP1_1 0.0001095279 0.0013957283134908426 / 0.004002216537936575 1.439059920097413e-05 / 4.3262437480883325e-07 0.002698972 2
233 KAT2B_3 0.0000000754 0.00036235601618888415 / 0.0056682839670987315 7.275549292242543e-06 / 6.222503271842437e-05 0.00301532 2
234 NBAS_2 0.0001936498 0.002248148734104571 / 0.003937219671693211 5.238094547402913e-05 / 2.261642163972036e-05 0.003092684 2
235 RPAP3_1 0.0000000959 0.006578021053153416 / 0.0003022930393277112 0.00010709405231539574 / 5.7996012896130105e-05 0.003440157 2
236 PCDH8_1 0.0000003649 0.001612584660708291 / 0.0053998526759721725 6.979705922681422e-07 / 2.352485760414308e-06 0.003506219 2
237 NRTN_1 0.0000000085 0.006576322331343084 / 0.000682440200485821 1.3872766655850854e-09 / 1.1570279948530293e-08 0.003629381 2
238 NFE2L3_3 0.0000025415 0.006071092121717285 / 0.001441190253067779 0.0007954168620537718 / 2.313845386160375e-05 0.003756141 2
239 AXL_2 0.0000082526 0.004702764394990607 / 0.0030062439789624545 1.694397819105341e-07 / 2.938209735715061e-06 0.003854504 2
240 FAM84B_1 0.0000011219 0.00253490211532945 / 0.006638130601347837 9.817330455454356e-07 / 1.8299892086956357e-05 0.004586516 2
241 SERPING1_2 0.0000000003 0.00029302171972017536 / 0.00899955161467775 5.171117305573901e-07 / 3.4719444187468846e-06 0.004646287 2
242 MAN2A2_1 0.0000016596 0.008666656930380014 / 0.0017164152096634118 3.010976905505238e-07 / 1.2681089550233342e-06 0.005191536 2
243 PPP1R1B_2 0.0000081910 0.0007369895164838126 / 0.015544944078315552 4.952255809431967e-06 / 0.0008507571424411441 0.008140967 2
244 LIM2_1 0.0000574583 0.015037462614525989 / 0.0066321488107590094 1.3552898512014677e-07 / 1.5995954452124522e-06 0.010834806 2
245 ENC1_1 0.0000008380 0.019200633106000394 / 0.0072430591690685955 9.369739248583604e-07 / 9.796657658766679e-08 0.013221846 2
246 TXNDC15_1 0.0002035799 0.01560397243862297 / 0.026007387241751754 1.3487999148831977e-05 / 2.383861518054849e-06 0.02080568 2
247 CTGF_1 0.0006621219 0.04284073842146925 / 0.004328209862304807 1.2802249170334234e-06 / 4.161322882701981e-06 0.023584474 2
248 EGFLAM_2 0.0000009904 9.101668425963222e-05 / 0.04959722009227676 2.2688565832705132e-07 / 4.996639973079422e-06 0.024844118 2
249 ARHGAP10_2 0.0000000002 1.0829140297466289e-09 3.358932763107935e-10 1.08291E-09 1
250 EBF3_1 0.0000002820 2.7109747094287326e-07 1.8343370720153953e-05 2.71097E-07 1
251 PLAGL2_1 0.0000000508 3.2501044823812903e-07 1.8455903922148852e-07 3.2501E-07 1
252 XKR4_3 0.0000000000 3.984768315573071e-07 3.1239365009333255e-05 3.98477E-07 1
253 HR_1 0.0000000121 9.224071980226081e-07 1.9179741330821166e-06 9.22407E-07 1
254 GLB1L2_1 0.0000000160 1.1263759452799203e-06 7.033045636092652e-08 1.12638E-06 1
255 GOLIM4_1 0.0000004900 1.1263759452799203e-06 6.007938707379104e-06 1.12638E-06 1
256 TMEM127_1 0.0000000593 1.1263759452799203e-06 4.773025688625418e-08 1.12638E-06 1
257 USP21_1 0.0000003387 1.1263759452799203e-06 9.225028218311642e-07 1.12638E-06 1
258 FAIM_5 0.0000000000 1.1673685534992903e-06 9.826697889420593e-07 1.16737E-06 1
259 COX19_2 0.0000000297 2.674810306988624e-06 6.962982384295879e-06 2.67481E-06 1
260 LRP10_3 0.0000000000 4.146152323500948e-06 2.8381722284939996e-06 4.14615E-06 1
261 ASPH_1 0.0000031107 5.198191671140737e-06 1.24607424448712e-09 5.19819E-06 1
262 CASP4_1 0.0000231527 5.198191671140737e-06 8.920036916236078e-07 5.19819E-06 1
263 PPFIBP1_1 0.0000009218 5.198191671140737e-06 2.822471900981502e-07 5.19819E-06 1
264 PRRX2_1 0.0000102422 5.198191671140737e-06 1.997454040091158e-06 5.19819E-06 1
265 TADA1_1 0.0000011043 5.198191671140737e-06 4.130298014547339e-06 5.19819E-06 1
266 FBXO15_2 0.0000000001 7.752739683840974e-06 1.0459642383728147e-08 7.75274E-06 1
267 RPRD1A_3 0.0000000001 1.0121621258597313e-05 5.117366799673119e-08 1.01216E-05 1
268 HS3ST3B1_2 0.0000000001 1.589621421980893e-05 5.712322089852472e-05 1.58962E-05 1
269 RBM39_1 0.0000000427 1.615375160694009e-05 1.0486585374452342e-06 1.61538E-05 1
270 MRPS34_1 0.0000059445 2.078130544858706e-05 3.007629978522511e-07 2.07813E-05 1
271 PPARD_1 0.0000000391 2.4400796134349794e-05 1.781378071484659e-07 2.44008E-05 1
272 TRIM29_2 0.0000000342 2.5328503789616034e-05 3.171256366090173e-06 2.53285E-05 1
273 SLITRK3_2 0.0000000001 2.606975599460185e-05 1.5642166542934073e-05 2.60698E-05 1
274 AOX1_1 0.0000000161 2.9249667673039124e-05 1.5889876142270276e-06 2.92497E-05 1
275 WDR41_1 0.0000008795 3.490933492066787e-05 0.00031815123884038185 3.49093E-05 1
276 WDR60_1 0.0000000100 3.54688199707126e-05 5.069649573469536e-05 3.54688E-05 1
277 ELOVL1_1 0.0000000046 3.613318380627543e-05 2.329132806551381e-05 3.61332E-05 1
278 ISYNA1_1 0.0000000671 4.335544688590604e-05 1.6739811178590666e-07 4.33554E-05 1
279 BTBD17_1 0.0000001085 4.559947241482223e-05 5.155148635414614e-07 4.55995E-05 1
280 E2F6_1 0.0000000779 4.559947241482223e-05 1.7462091622562324e-05 4.55995E-05 1
281 REEP5_1 0.0000012251 4.559947241482223e-05 4.0559240566408105e-05 4.55995E-05 1
282 HIF3A_2 0.0000001724 5.1802263378395004e-05 7.343981030754773e-06 5.18023E-05 1
283 PLIN3_1 0.0000007202 7.498301012054149e-05 8.715915351978061e-08 7.4983E-05 1
284 SLC25A43_1 0.0000000584 7.498301012054149e-05 1.042304728724042e-06 7.4983E-05 1
285 NINL_2 0.0000000000 8.157777488089495e-05 1.9047854067387114e-06 8.15778E-05 1
286 ZNF232_2 0.0000000005 9.615096996117447e-05 2.7228077881606553e-05 9.6151E-05 1
287 SIRT4_5 0.0000000006 9.759198409764184e-05 0.00022059348443664346 9.7592E-05 1
288 TP53BP2_1 0.0000015006 0.00011602560329098725 1.0705081193459222e-06 0.000116026 1
289 DLGAP1_1 0.0000000768 0.0001432193232982916 3.5620325640614317e-07 0.000143219 1
290 ELL2_1 0.0000001831 0.00014547367344876742 1.8060650315234512e-06 0.000145474 1
291 L3MBTL1_1 0.0000000672 0.00015165886425239433 2.7256307870565235e-06 0.000151659 1
292 VCL_1 0.0000000164 0.00015165886425239433 3.3683533578357084e-06 0.000151659 1
293 FOXN4_1 0.0000000718 0.00018648294090879803 6.71170895523933e-08 0.000186483 1
294 DGKD_2 0.0000000001 0.00021891772305978252 3.0596605696933097e-07 0.000218918 1
295 UHMK1_2 0.0000022832 0.0002538027145357861 1.287838376941801e-06 0.000253803 1
296 ATG10_1 0.0000013709 0.00045105792374135455 1.9817995812370057e-05 0.000451058 1
297 RTN4_1 0.0000004000 0.0005279514394131604 2.4302265052169763e-06 0.000527951 1
298 ZBTB34_2 0.0000000006 0.000905796995991497 2.480782410785219e-06 0.000905797 1
299 TRAPPC1_1 0.0000002410 0.0009321635980700065 5.038494138176741e-08 0.000932164 1
300 MAN1A1_1 0.0000012120 0.0010091155669931342 9.89628655829039e-07 0.001009116 1
301 GPR155_1 0.0000001571 0.0010353911778693099 2.456527177029259e-08 0.001035391 1
302 NUP205_1 0.0000011129 0.0012133361599562802 4.618395361515403e-05 0.001213336 1
303 DFNA5_1 0.0000000842 0.0013248126277991738 1.0306269703522314e-06 0.001324813 1
304 ESYT2_1 0.0000000362 0.0014584828902455792 1.480537378886556e-06 0.001458483 1
305 ARRDC5_1 0.0000004478 0.0016631235717637551 5.470825563951457e-06 0.001663124 1
306 WWOX_1 0.0000000652 0.001710012299865077 3.466057717888151e-05 0.001710012 1
307 TTC12_1 0.0000000828 0.001757554115983901 1.1207466412214644e-06 0.001757554 1
308 PHLDA1_1 0.0000002242 0.0025176594807100345 2.681228774385004e-07 0.002517659 1
309 USP44_2 0.0000000006 0.002828735395322951 7.615307891070635e-07 0.002828735 1
310 PLTP_1 0.0000001423 0.0037115156714849027 6.256739082396771e-06 0.003711516 1
311 FOXK2_2 0.0017280500 0.004268133535531114 1.124004668909467e-06 0.004268134 1
312 ERRFI1_1 0.0000343124 0.004549100059734061 2.615853467480574e-06 0.0045491 1
313 NCAPG2_2 0.0000096301 0.004679455399141524 3.410090272140929e-05 0.004679455 1
314 GNG12_2 0.0000008966 0.004702764394990607 2.448152787066068e-07 0.004702764 1
315 GTF2IRD1_2 0.0000000000 0.005180332874805364 1.0191189286267774e-05 0.005180333 1
316 CDH13_1 0.0000528396 0.008698504315979544 5.505206380486848e-07 0.008698504 1
317 USPL1_1 0.0000887089 0.008919618004927028 2.867060371186775e-05 0.008919618 1
318 C8orf33_2 0.0000000686 0.012040847937930112 6.965053271201718e-06 0.012040848 1
319 LARP4_1 0.0000539238 0.012598829000918008 1.5446384568414948e-07 0.012598829 1
320 WISP2_3 0.0007560493 0.015549504727258205 4.1338081640385414e-05 0.015549505 1
321 ACTR3B_1 0.0000005421 0.01578579910468178 2.8755424998338056e-06 0.015785799 1
322 CACNA1H_1 0.0000005564 0.016412811603890378 2.7000252287495107e-06 0.016412812 1
323 KIT_5 0.0000464952 0.018517123226998455 6.704030752101419e-08 0.018517123 1
324 PFKFB4_1 0.0000652997 0.020508581406833964 3.9540280994682333e-05 0.020508581 1
325 PRKCA_1 0.0000002757 0.022453642395359744 8.550515929117645e-06 0.022453642 1
326 PPIB_1 0.0005395298 0.022633220383071653 1.1620529438552381e-07 0.02263322 1
327 GUK1_1 0.0002165806 0.025889538503308045 0.00027733726642677973 0.025889539 1
328 TOMM20_1 0.0000295101 0.026424697119045135 5.7696335620157635e-06 0.026424697 1
329 MCFD2_1 0.0000296801 0.02889039127169977 5.21788791253075e-06 0.028890391 1
330 ARL2BP_1 0.0009748737 0.03656942798482464 2.769366837708274e-07 0.036569428 1
331 DSTN_2 0.0000209668 0.040590852862758056 0.0002808473162478281 0.040590853 1
다음으로, 본 발명에서 기능하플로타입을 이용한 GBLscan을 통하여 산출된, 각 약물타입 별로 약물에 대한 반응성에 영향을 미치는 바이오마커에 대하여 설명한다.
구체적으로, 약물타입(Drug Class)의 구분 별로, ABL의 바이오 마커 108개(표 15참조), CHROMATIN의 바이오 마커 132개(표 16참조), EGFR의 바이오 마커 832개(표 17참조), ERK_MAPK의 바이오 마커 42개(표 18참조), IGFR의 바이오 마커 153개(표 19참조), MITOSIS의 바이오 마커 88개(표 20참조)이다.
아래 [표 15] 내지 [표 20]에는 약물타입 별로 본 발명에 의해 발굴된 바이오 마커들이 포함되어 표시되어 있다. 여기서 바이오 마커의 형태 및 표현 방식은 전술한 암종류별로 구분된 바이오 마커와 동일하다.
특정 pathway & signaling를 표적으로 하는 약물타입(DrugClass) 정의
구분 DrugClass Drugs Pathway & signaling(Target gene & function)
1 ABL Imatinib, GNF-2, Dasatinib, Saracatinib, WH-4-023, Bosutinib, Ponatinib, HG-5-113-01, Nilotinib ABL, SRC, KIT, PDGFR, ABL1,TEC, LOK, LTK, TRCB,
2 CHROMATIN Phenformin, AICA_Ribonucleotide, Daporinad HDAC, RAR, HDAC inhibitor Class I, IIa, IIb, IV; HDAC6, EGFR, G9a(EHMT2), GLP(EHMT1), Q8TEK3 (DOT1L), BRD2, BRD3, BRD4
3 EGFR Gefitinib, Erlotinib, Cetuiximab, Lapatinib, Afatinib, HG-5-88-01, CP724714, Pelitinib ERBB2, EGFR, ADCK4
4 ERK_MAPK Dabrafenib, VX-11e, AZ628, Selumetinib, CI-1040, PD0325901, Selumetinib, Refametinib, Trametinib, TL-2-105, HG6-64-1, PLX-4720, SB590885, SL0101, CMK, FMK, FR=180204 MAP2K1 (MEK1), MAP2K2 (MEK2), BRAF, ERK, RSK, AURKB, PIM3, CRAF, BRAFV600E, TAK, MAP4K5
5 IGFR CSK1904529A, BMS-536924, BMS-754807, Linsitinib IGF1R
6 MITOSIS Dacinostat, JQ1, SGC0946, VNLG/124, UNC0638, Belinostat, CUDC-101, Vorinostat, CAY10603, AR-42, I-BET-762, Tubastatin A, PFI-1, Entinostat, JQ12 AURKB, MPS1, KIF11, AURKA, PLK3, AURKC, FLT3, ABL1, JAK2, PLK3
[표 15]에는 ABL 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 15]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 37에는 [표 15]에 기재된 바이오마커들 중 주요 바이오마커들의 ABL 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
ABL 약물에 대한 반응성 바이오 마커 및 약물과의 반응성 검증 결과
No. FRH Variants(마커) Var_Drug(pval) Var_Exp(Pval)
1 MEI1_1 22_41743050_G_A 4.85E-06 0.048265101
2 MYO1E_1 15_59223315_G_A 9.45E-06 0.007356789
3 HSPG2_1 1_21855190_T_G 3.11E-05 0.047030976
4 DUS1L_1 17_82060026_C_T 3.91E-05 0.03583129
5 ANXA2_1 15_60382524_A_G 5.75E-05 0.01380595
6 CDA_1 1_20613970_T_C 0.000123749 0.01233326
7 R3HDM1_1 2_135621624_GT_G 0.000150326 0.007933574
8 HMGB1_1 13_30465849_T_C 0.000160907 1.54E-07
9 TRIM35_1 8_27311444_G_A 0.000300142 0.010188344
10 NMT2_1 10_15119275_A_C 0.000338877 0.015194231
11 WWC1_1 5_168453939_T_G 0.000400908 0.007809824
12 EPB41_1 1_28987461_G_A 0.000407874 0.032052572
13 TGS1_1 8_55790504_CT_C 0.000507403 0.000527822
14 CLIP4_1 2_29189528_C_T 0.000680402 0.012550596
15 PPFIBP1_1 12_27671307_G_A 0.000932648 0.043451196
16 GNG12_1 1_67707581_C_T 0.000988807 0.022170841
17 MATN3_1 2_20002159_T_TACAC 0.000997596 0.02071966
18 LAMA5_1 20_62325178_T_C 0.001153135 0.010970602
19 SECISBP2_1 9_89319872_A_G 0.001203729 0.020014055
20 CARD10_1 22_37506170_T_C 0.001543214 0.032625328
21 CELF3_1 1_151714507_T_A 0.001901287 0.026406472
22 RPRD2_1 1_150470594_A_C 0.002054115 0.049994398
23 LONP1_1 19_5707040_C_G 0.002145064 0.014919269
24 CELSR1_1 22_46397746_T_G 0.002174791 0.029193759
25 AVPI1_1 10_97677649_A_G 0.002288252 0.001581419
26 HEATR5A_1 14_31321626_G_C 0.002664426 0.037377577
27 ABCC3_1 17_50687493_T_G 0.002687235 0.008875192
28 BCL9L_1 11_118897861_A_C 0.003330363 0.034238861
29 ATP9A_1 20_51712877_T_C 0.003711948 0.007942465
30 PPL_1 16_4899248_T_G 0.003916476 0.036032874
31 WTIP_1 19_34482571_G_A 0.004231715 0.04930162
32 SEC11C_1 18_59152698_T_C 0.004414812 0.00225746
33 RIN2_1 20_19990244_G_A 0.004460992 0.013004393
34 VPS13C_1 15_61910091_C_T 0.004506626 0.031208891
35 WAS_1 X_48691219_A_C 0.004569497 0.02612273
36 ITGA2_1 5_53062931_TA_T 0.005690843 0.016066848
37 SNX6_1 14_34581380_G_T 0.006210652 0.003379828
38 ITGB5_1 3_124769064_T_G 0.006500498 0.000658854
39 KIF13A_1 6_17796543_CTT_C 0.006766834 0.022643788
40 HNRNPD_1 4_82373387_A_G 0.006955259 0.035424294
41 PDE7A_1 8_65724444_TATAA_T 0.006982791 0.049491005
42 TAB1_1 22_39417620_CA_C 0.007324331 0.041922448
43 TSPAN17_1 5_176657159_A_G 0.009147394 0.031164715
44 MYO1C_1 17_1484178_C_T 0.009858187 0.007802374
45 CDC42BPA_1 1_227318293_C_CG 0.010493359 0.000358115
46 ACTN4_1 19_38728028_T_G 0.011156467 0.005408687
47 MET_1 7_116757685_T_G 0.012677621 5.06E-05
48 GPC1_1 2_240451010_T_G 0.013814172 0.00346274
49 HERC1_1 15_63725445_C_A 0.014048274 0.007901005
50 RAB13_1 1_153982198_T_C 0.015384036 0.007436568
51 UBE2N_1 12_93411182_C_T 0.015885474 1.51E-06
52 STRBP_1 9_123266116_C_G 0.017136074 0.001078377
53 EZH1_1 17_42729015_C_CA 0.018478925 0.00312166
54 RNASEH2B_1 13_50956394_G_T 0.01852788 0.005925233
55 LTBP3_1 11_65547976_T_G 0.019306265 0.001002058
56 EGFR_1 7_55205662_A_C 0.020078083 0.000779757
57 LPIN3_1 20_41358465_C_G 0.020089538 6.89E-05
58 PHF21A_1 11_46079428_CT_C 0.020895851 0.00265565
59 SPR_1 2_72891611_A_C 0.021434042 0.000101783
60 RCHY1_1 4_75509142_T_A 0.022232183 7.00E-06
61 EPHA2_1 1_16148437_A_C 0.023495387 0.003022958
62 GMEB1_1 1_28690201_G_T 0.025608914 0.005247117
63 KRI1_1 19_10565667_A_T 0.026306225 2.71E-07
64 MADD_1 11_47325027_T_C 0.027877784 0.001497343
65 ITGAV_1 2_186622542_G_T 0.027935094 0.000708467
66 FN1_1 2_215384980_GA_G 0.028277863 0.006411138
67 ITGB8_1 7_20404676_A_G 0.03058173 0.00229404
68 MYOF_1 10_93341723_C_T 0.031403296 1.02E-05
69 MICALL1_1 22_37911902_T_C 0.031573614 0.005136303
70 TXNL4A_1 18_80033872_T_C 0.035325542 0.000843174
71 AHR_1 7_17339074_A_C 0.036910472 0.009928124
72 HCFC1_1 X_153963207_T_G 0.040430125 0.001579155
73 TJP1_1 15_29761137_A_C 0.040841908 0.005695684
74 DPF1_1 19_38216453_A_C 0.041618699 0.002769532
75 TUFT1_1 1_151565936_G_A 0.042197322 0.004559558
76 CNN3_1 1_94903018_TA_T 0.044343955 0.002044509
77 CALD1_1 7_134891710_CTT_C 0.044361406 0.006749784
78 DCP1A_1 3_53342054_G_C 0.044944752 0.003471409
79 CNBP_1 3_129183756_G_T 0.045255004 0.001660507
80 CDC42BPB_1 14_102952453_T_G 0.046084899 0.003315245
81 ZNF557_2 19_7083618_A_G / 19_7083750_A_G 0.00011707290070365984 / 6.389914683218769e-05 1.6329734686551152e-07 / 4.640996358288638e-07
82 TSC22D1_2 13_44574373_G_T / 13_44436480_G_A 0.00011795878001107085 / 0.0037018440403040202 0.0064804726533923464 / 0.03180017409101453
83 KDM2B_2 12_121579943_C_CA / 12_121444386_T_G 0.0001937979358872413 / 0.00792596940180308 0.01794421156168876 / 0.019501973878425127
84 TMEM206_3 1_212365230_C_T / 1_212377513_G_A / 1_212377773_C_T 0.00020121681284993422 / 0.0003349904631200686 / 5.8829810838971604e-05 0.015527989364148976 / 0.03220676605475732 / 0.012309846725869236
85 CNOT10_2 3_32727933_TAA_T / 3_32704796_GT_G 0.0004336510041481753 / 0.008993061026214434 0.009535253937430231 / 0.00725632017358903
86 AHNAK2_6 14_104939818_T_C / 14_104947943_T_G / 14_104955559_A_C / 14_104949306_T_C / 14_104950989_T_C / 14_104944923_A_G 0.0013733032135289033 / 9.993054536650758e-05 / 0.0009826292819827367 / 0.008303598761450906 / 0.009151781473220755 / 0.016815570915054142 0.0009255099251631373 / 0.014057846162243957 / 0.00506490504122054 / 0.005256944789299486 / 0.039201386575838416 / 0.004782218518041667
87 HNRNPH1_2 5_179614784_GAAAAA_G / 5_179616992_TA_T 0.0015622332101704927 / 0.013101283499781437 0.009729395921872941 / 0.006282233288170697
88 KCTD11_2 17_7355768_G_A / 17_7353417_T_G 0.0021551269324258863 / 0.011987917410278012 0.042125567363077016 / 0.0012683162409826913
89 DCBLD2_2 3_98800637_G_A / 3_98822022_G_A 0.002171037536345973 / 0.000251692831370466 0.02405283820151249 / 0.02321925017861924
90 MICALL2_6 7_1434706_A_T / 7_1436884_C_A / 7_1436960_A_G / 7_1434574_G_A / 7_1438692_G_A / 7_1438940_G_A 0.0035785281207345704 / 0.005806506395454868 / 0.0023336782590812483 / 0.003953693182824404 / 0.01322256820373324 / 0.01322256820373324 0.03116600791585888 / 0.020144032243767682 / 0.0387968938865376 / 0.018579241850634483 / 0.001706040259270731 / 0.001706040259270731
91 YEATS4_3 12_69360050_G_A / 12_69360067_T_C / 12_69359732_G_C 0.004863813186856697 / 0.017375818716536366 / 0.03137776422130159 0.00020734016607029562 / 9.576513142549652e-05 / 0.00015854860163792644
92 FAM129B_2 9_127505498_C_G / 9_127507507_A_G 0.0058285941972244645 / 0.02690463941303876 0.011307547073529664 / 0.009068416405751362
93 DAZAP1_2 19_1432575_T_C / 19_1434836_G_C 0.007270894232908141 / 0.04710249822900437 0.008783799588482919 / 0.0025498805972486143
94 TRIO_2 5_14390880_CT_C / 5_14489165_TA_T 0.008880626014071066 / 0.01650056581622358 7.026077789590974e-05 / 0.0025442006562780626
95 LTBR_2 12_6385217_T_C / 12_6385074_A_G 0.009079148191429435 / 0.006460458599235777 9.805545850814532e-05 / 0.044833733345219534
96 CRIM1_2 2_36479368_G_C / 2_36441370_A_C 0.009119609813496462 / 0.019906184227680684 0.012444715286562538 / 0.003648330338783967
97 LRRC1_2 6_53795560_C_T / 6_53922469_G_C 0.01198676814286411 / 0.0006843529222630762 0.000908035692517222 / 0.04843244804719673
98 PLEC_3 8_143935900_T_G / 8_143916360_A_G / 8_143919099_A_G 0.014640529544546175 / 0.009983558087568838 / 0.034402276881097434 0.0004960012901022363 / 0.00910116635228719 / 0.0010288222361061275
99 CCAR1_4 10_68737725_A_G / 10_68749117_T_C / 10_68786466_C_T / 10_68747145_CT_C 0.01483460962771855 / 0.019812419206917474 / 0.021724978822350548 / 0.012199365670034771 0.007861846127742463 / 0.007748422295395019 / 0.009002153564015953 / 0.007417608363424872
100 PBRM1_10 3_52550415_T_TCTC / 3_52550699_A_G / 3_52576635_T_A / 3_52603470_C_G / 3_52609291_A_G / 3_52658108_G_A / 3_52658343_C_G / 3_52642048_AC_A / 3_52642050_A_T / 3_52658412_CTT_C 0.015475400089384512 / 0.0016628718776702444 / 0.035404535122126136 / 0.013312042665148668 / 0.0242839606361519 / 0.02159841119723304 / 0.03729870903666122 / 0.025323429673084204 / 0.025323429673084204 / 0.0001941847064581337 0.0035430700286634563 / 0.0001926448792301472 / 0.007441673662340349 / 0.002758979013645352 / 0.0010612844220239503 / 0.004958532862731571 / 0.004683945580784586 / 0.00010786476378721626 / 0.00010786476378721626 / 0.04797045127180218
101 EPAS1_2 2_46356096_C_A / 2_46375583_T_C 0.01783131944184612 / 0.0010999393665466503 0.008349664569290316 / 0.024779624499683697
102 MYL12B_2 18_3277079_C_A / 18_3261766_G_T 0.02040887855273308 / 0.006963645724708455 0.0006636499143577351 / 0.002628020597022407
103 ASPH_3 8_61578734_T_G / 8_61642872_G_A / 8_61638365_TA_T 0.02703041744922913 / 0.04217140046834995 / 0.0037026849241301204 0.00027481062695969863 / 9.242250914202104e-05 / 0.0033421074285719613
104 CTTN_2 11_70433765_G_C / 11_70433037_T_G 0.028796315723836858 / 0.0215077683383786 0.008528354106314544 / 0.004388396641544275
105 GBP3_2 1_89009135_A_G / 1_89013185_G_A 0.03712796271516626 / 0.046403726190448136 2.531316619591342e-10 / 0.003766535351837685
106 RBM6_3 3_50077082_C_T / 3_50066484_G_A / 3_50075273_C_A 0.03754138190716002 / 0.009406589543431777 / 0.006286329345703225 4.469564601606787e-06 / 0.014325869585835831 / 0.04790544676634136
107 GULP1_2 2_188589974_C_CT / 2_188569425_C_A 0.04155742757047321 / 0.00797269939608827 0.004507263398919969 / 0.006203700518672077
108 RAI14_2 5_34822821_T_C / 5_34795871_A_G 6.659980942617595e-05 / 0.005987810799744655 0.002995737088482826 / 0.006423617908157835
[표 16]에는 CHROMATIN 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 16]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 38에는 [표 16]에 기재된 바이오마커들 중 주요 바이오마커들의 CHROMATIN 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
CHROMATIN 약물에 대한 반응성 바이오 마커 및 약물과의 반응성 검증 결과
No. FRH Variants(마커) Var_Drug(pval) Var_Exp(Pval)
1 SPR_1 2_72891611_A_C 1.13E-09 0.000101783
2 BCL9L_1 11_118897861_A_C 3.13E-08 0.034238861
3 ZDHHC7_1 16_84981848_T_G 1.25E-07 0.007398316
4 CCDC69_1 5_151185396_T_C 2.83E-07 0.005439839
5 DDX60_1 4_168220820_G_T 4.91E-07 0.047715445
6 RASSF5_1 1_206507640_A_C 6.00E-07 0.042432506
7 C21orf58_1 21_46302477_A_G 5.32E-06 0.028316032
8 KIAA0922_1 4_153466445_G_C 1.35E-05 0.014460739
9 NR2F2_1 15_96331144_C_T 1.41E-05 0.041165877
10 WWC2_1 4_183261395_G_T 2.29E-05 0.017749371
11 ERRFI1_1 1_8013331_A_G 3.34E-05 0.000188249
12 KIAA1191_1 5_176361895_T_C 4.29E-05 0.02279099
13 QSOX1_1 1_180196892_T_G 5.61E-05 0.048904626
14 NTN4_1 12_95683554_A_C 5.86E-05 0.007698614
15 KIFC3_1 16_57765532_T_G 6.78E-05 0.038497261
16 LPP_1 3_188484677_T_G 7.25E-05 0.027828249
17 TUFT1_1 1_151565936_G_A 8.20E-05 0.004559558
18 CDC14B_1 9_96496393_T_TACC 0.000102442 0.034844355
19 DTX1_1 12_113093500_A_T 0.000105094 0.02107386
20 P4HA2_1 5_132227207_C_T 0.000133282 0.048816114
21 ARHGAP25_1 2_68818005_T_G 0.000231771 0.004043302
22 TIMM13_1 19_2425296_G_C 0.000236058 0.025389471
23 CAST_1 5_96741643_A_C 0.000249549 0.007284203
24 PTPN12_1 7_77627576_G_C 0.000317226 0.012844299
25 MED28_1 4_17614675_T_G 0.000322999 0.029816577
26 SLC35F5_1 2_113723196_TA_T 0.000333219 0.009792442
27 TPBG_1 6_82364929_T_C 0.000334942 0.003828919
28 CD79B_1 17_63932334_A_C 0.000528438 0.048052988
29 DIRC2_1 3_122856322_A_G 0.000825084 0.013416691
30 UEVLD_1 11_18558312_C_A 0.000960879 0.026771319
31 LRP10_1 14_22875577_A_C 0.001001744 0.013008771
32 UGDH_1 4_39504307_CA_C 0.001468644 0.048378289
33 VMP1_1 17_59841357_A_C 0.001495454 0.00700708
34 DOT1L_1 19_2190948_TTGG_T 0.001590625 0.039142783
35 OSMR_1 5_38933647_C_T 0.001601244 0.048095084
36 CYR61_1 1_85581605_TA_T 0.001618999 0.000620768
37 EMP1_1 12_13211531_T_G 0.001632317 0.001600571
38 PRDM2_1 1_13781628_C_T 0.001853506 0.028812792
39 UBE2N_1 12_93411182_C_T 0.001919604 1.51E-06
40 PDE7A_1 8_65724444_TATAA_T 0.001930609 0.049491005
41 ZNF775_1 7_150397765_G_A 0.002410672 0.02103353
42 ACSS2_1 20_34920910_T_G 0.002415783 0.038456731
43 TNRC6C_1 17_78049826_A_C 0.002419277 0.037719795
44 OPTN_1 10_13108909_T_C 0.002658339 0.009854403
45 FHL2_1 2_105398737_G_C 0.002849654 0.020214714
46 TSR2_1 X_54440646_T_G 0.003023868 0.016676081
47 PON2_1 7_95406313_A_C 0.003172125 9.37E-06
48 RIN2_1 20_19990244_G_A 0.003495398 0.013004393
49 ACVR1_1 2_157780624_GA_G 0.003989606 0.003394881
50 ARRB2_1 17_4720324_T_G 0.004024916 0.04522165
51 STRBP_1 9_123266116_C_G 0.005108062 0.001078377
52 APLP2_1 11_130110790_G_A 0.006767893 0.002129537
53 PPM1D_1 17_60656555_C_G 0.007483948 0.004279928
54 MICALL2_1 7_1442358_T_G 0.008296918 0.00384944
55 SDC4_1 20_45330303_T_G 0.00885313 0.000496261
56 MAP4K1_1 19_38617327_T_G 0.009035501 0.013203631
57 DDX51_1 12_132144264_G_A 0.00950629 0.039746501
58 CD63_1 12_55725568_A_C 0.010191282 0.006277176
59 TSEN34_1 19_54192354_T_G 0.015320711 0.001848481
60 RND3_1 2_150487464_GA_G 0.016355986 0.009852344
61 DYNC1LI2_1 16_66723584_GTTT_G 0.020987801 0.00547115
62 ATG4D_1 19_10547046_A_G 0.025677384 0.001170719
63 TEAD4_1 12_3019250_C_T 0.025841261 0.001625407
64 SPATS2L_1 2_200329386_C_A 0.025958546 0.003348759
65 TCF3_1 19_1627423_T_C 0.04297822 0.006623288
66 GPX8_1 5_55164338_T_C 0.043500083 0.000150103
67 CHD7_1 8_60781091_A_C 0.049386713 0.009144258
68 IQCB1_1 3_121788568_C_T 0.049430015 1.56E-06
69 CD84_2 1_160549875_A_G / 1_160550877_C_G 0.00011388443370850483 / 0.0007812325110491749 0.011914227680681896 / 0.04088607952168802
70 GSN_2 9_121300011_T_G / 9_121321305_A_C 0.00014939533964484881 / 0.03316947281106813 0.027350252864946387 / 0.0036521684936499576
71 PTPRC_2 1_198703381_A_C / 1_198752063_T_C 0.00016494389721910315 / 0.0013479983597789753 0.02703768662070396 / 0.04525193826667434
72 DAG1_2 3_49531399_T_G / 3_49530812_A_G 0.00020026524182288077 / 0.006009115344867996 0.000829773140052924 / 0.031395065099950874
73 CLEC16A_3 16_11156556_C_A / 16_11060913_G_A / 16_11042191_C_G 0.0002094249249848047 / 6.263351817687237e-07 / 0.000591215275919509 0.00562768771681351 / 0.001657798405900209 / 0.0008509758531100063
74 SEMA3C_2 7_80748927_A_C / 7_80758439_T_G 0.00023588106210457256 / 0.002402247845707725 0.04566908222348532 / 0.022537466343331126
75 MYO1E_3 15_59272288_G_C / 15_59223315_G_A / 15_59138181_A_C 0.0002531868313324391 / 0.017294701356675626 / 0.012353995820357604 0.006181875879725325 / 0.0073567891788311425 / 0.000506485287819266
76 FBRSL1_2 12_132582046_C_T / 12_132490757_A_G 0.0002541174963279791 / 0.0016132414574028821 0.017168862085872382 / 0.014332097218830869
77 PLAUR_2 19_43665377_C_A / 19_43665506_A_C 0.0004816822177162012 / 0.000329711238045009 0.013703989625456308 / 0.02821338934893095
78 UPP1_2 7_48108129_C_G / 7_48108147_T_G 0.0005053096271809359 / 0.032569834532674265 0.0002337913556195707 / 0.0015081620173450355
79 TM4SF1_3 3_149375338_T_G / 3_149375342_T_G / 3_149375345_A_G 0.0006450924297222392 / 0.00041880937510606033 / 0.0045963625050391855 0.00025288036755393063 / 0.005766354533635817 / 0.02993773631668
80 ZNF430_4 19_21020746_C_T / 19_21022725_C_T / 19_21034405_A_G / 19_21022773_T_G 0.0006475458714423392 / 0.0074498992574896375 / 0.001227492240630532 / 0.0008007999312255407 0.0014493947676260713 / 7.931044376997757e-06 / 0.043344266998276815 / 0.024171318376603662
81 CYTIP_2 2_157427544_C_T / 2_157427198_A_G 0.000837855207497095 / 0.004314698497827655 0.016967272956506692 / 0.0066627404504453576
82 FAM129B_3 9_127531490_GA_G / 9_127525143_T_G / 9_127578821_C_G 0.000922821517572468 / 0.0002411893320187629 / 8.276570085958934e-05 0.031013612085774283 / 0.010661251800502545 / 0.0009666899162254512
83 SEC11C_2 18_59152698_T_C / 18_59139887_T_G 0.0009260156067678403 / 0.049013482279269986 0.0022574597582570113 / 0.007830715004334495
84 SERPINB6_3 6_2955641_A_C / 6_2955644_A_C / 6_2959401_A_C 0.001043382693355795 / 0.024971781697072672 / 0.0010045092345408332 0.01355817950847752 / 0.003892754006925403 / 0.039976665559382514
85 HEXB_5 5_74696581_T_G / 5_74696784_G_A / 5_74715459_CT_C / 5_74715716_T_A / 5_74715716_T_TA 0.0011109425360834742 / 0.0004588063308077307 / 0.00032306189000466006 / 0.0012875359612772113 / 0.013801634858228495 0.0076182846696747 / 0.037654298343869685 / 0.0009700644073606587 / 0.0006894634360309071 / 0.008716125756790354
86 CHAF1A_5 19_4431899_C_T / 19_4442339_C_T / 19_4443049_T_C / 19_4422720_A_G / 19_4442532_T_C 0.0013371878989745694 / 4.704638650715319e-06 / 0.002601657035134123 / 0.00848724820837247 / 0.0008277326854784058 1.913287638550038e-06 / 2.142565869765625e-07 / 2.294297809586175e-06 / 0.024620616607439628 / 0.010330162535447171
87 DTNBP1_5 6_15522870_T_C / 6_15662701_T_G / 6_15524467_T_C / 6_15637909_C_A / 6_15651411_GA_G 0.00140727662017035 / 0.0007340285829190258 / 0.000563588210134313 / 0.0015365486679584585 / 0.012631556103580063 0.02838345350893315 / 0.001004314451212422 / 0.0038345211108275156 / 0.02038116210082405 / 0.0014349866138238813
88 NPC1_6 18_23533587_A_G / 18_23531466_TG_T / 18_23543332_G_GA / 18_23556539_A_C / 18_23551637_T_C / 18_23540944_CT_C 0.001437129484746987 / 7.150026947753571e-05 / 0.0029007221429512673 / 0.0002201554381797956 / 0.00283655966462793 / 0.003557570436749789 0.049542946772028126 / 0.03680603821841593 / 0.0011845211365567286 / 0.011218938268584914 / 0.00977392034448968 / 0.040822963170832685
89 DCK_2 4_71023678_G_A / 4_71023683_A_T 0.0025792753639569685 / 0.004519208391207111 0.0495745351142595 / 0.03292890320415958
90 MYOF_5 10_93402739_A_T / 10_93341723_C_T / 10_93456833_C_T / 10_93359764_G_A / 10_93379679_T_C 0.0031553117726987327 / 0.0003251886046767745 / 0.0012115888716542418 / 0.0011033881652818386 / 1.1152022033742226e-05 0.008275987890594253 / 1.0154009952651607e-05 / 4.5730649026336375e-05 / 0.04572104850464974 / 0.0006543495060757152
91 CNOT6L_4 4_77720488_T_G / 4_77819455_A_C / 4_77720486_A_G / 4_77726534_A_C 0.003413275456645043 / 0.004884718330098437 / 1.3017900050261066e-05 / 0.013675885143940456 0.00045440611666765506 / 0.0041059419980858354 / 0.003812687853894012 / 0.002323583718729919
92 SNX24_2 5_122845530_G_A / 5_123023772_TA_T 0.003825812212204896 / 0.005412166991196986 0.032851178784777335 / 0.010215103992736332
93 SQSTM1_4 5_179833153_C_T / 5_179833213_G_A / 5_179822433_T_C / 5_179832842_G_C 0.004089948495769615 / 0.007896407107059047 / 1.0391418374918043e-11 / 5.901642675392869e-07 0.014656854055438881 / 0.015290841042493631 / 0.0024949336391905503 / 0.0024314650981475784
94 CTTN_7 11_70419876_A_C / 11_70419880_T_C / 11_70433755_A_G / 11_70433765_G_C / 11_70407283_C_T / 11_70433037_T_G / 11_70435435_C_T 0.004793877560857165 / 0.0029267237988671235 / 0.0002662301400632249 / 2.1853977605406948e-05 / 5.710606729324503e-07 / 0.00010373335018763256 / 0.002764146814493288 0.00030309409522359497 / 0.003131141961303907 / 0.02047999046614251 / 0.008528354106314544 / 0.005941149857145408 / 0.004388396641544275 / 0.013709818259161087
95 KDM2B_4 12_121580903_A_C / 12_121579943_C_CA / 12_121444386_T_G / 12_121580252_TG_T 0.004804220239616889 / 5.298915204579247e-06 / 7.807472174797022e-08 / 0.024172279934987287 0.04290936139558865 / 0.01794421156168876 / 0.019501973878425127 / 0.004964292850525796
96 CTNNA1_4 5_138812304_T_G / 5_138824633_A_C / 5_138933920_C_T / 5_138812289_C_G 0.005041441550878414 / 0.009914746459480685 / 0.00032076772718977635 / 0.013542487211798218 0.013339032203366944 / 0.004284224604488671 / 0.00010488952235634391 / 0.0010251811268691103
97 TRIOBP_2 22_37751927_A_C / 22_37757383_C_G 0.0053165450762140245 / 0.0016386338499532257 0.008760146502383994 / 8.295724649894844e-05
98 EGR1_2 5_138467153_A_C / 5_138466811_A_C 0.005590395913285018 / 0.00018684738505679937 0.006707694887573882 / 0.00027393305226194143
99 MYCBP2_8 13_77070727_G_A / 13_77165156_A_T / 13_77098982_T_G / 13_77051091_G_A / 13_77051098_A_C / 13_77058230_T_G / 13_77061586_T_C / 13_77267898_T_G 0.008036895878308711 / 0.012181733375411912 / 0.0004449974043640469 / 0.0007742974469162077 / 0.004690941013903492 / 0.022811552981952272 / 0.0002327215378800939 / 0.004205585533754351 0.029852585169277374 / 0.00045980757332588846 / 0.0038229074053839733 / 0.00017518564876142542 / 4.397700485560215e-05 / 0.0032117224925540928 / 0.030373685856290068 / 0.00592396173483849
100 TCF4_6 18_55464257_C_A / 18_55463971_TGTGTGTGA_T / 18_55275657_A_G / 18_55275664_A_G / 18_55403517_A_C / 18_55461237_G_T 0.008090959269238968 / 0.0056178520760126974 / 0.001559758175866868 / 0.012472558742737408 / 0.0011862271176169732 / 0.006912522905586032 0.032420073593804284 / 0.03333184670009802 / 0.0013930308437610063 / 0.00619762753769391 / 1.5397131093463103e-06 / 0.04572000946513434
101 LAMC1_3 1_183132309_A_C / 1_183131203_C_T / 1_183131172_CAA_C 0.008181813089040216 / 3.4320876665108484e-05 / 0.02745630451997897 0.01655294869349123 / 0.03400723316751987 / 0.002417084109353407
102 DCBLD2_2 3_98800637_G_A / 3_98822022_G_A 0.00885632710582371 / 0.003195091628487625 0.02405283820151249 / 0.02321925017861924
103 FAM114A1_2 4_38905545_G_A / 4_38905553_A_G 0.008914101428030875 / 9.057397575383816e-05 0.004385515653682114 / 0.0017226027017899913
104 RXRA_2 9_134379472_C_A / 9_134432274_T_C 0.01212893284996885 / 0.0010613625702847742 0.008306707838893354 / 0.02628295923936911
105 TXNL4A_2 18_80033872_T_C / 18_79988525_A_C 0.013055851849266827 / 0.0007334523399616647 0.0008431735834914795 / 0.0008431735834914795
106 PLOD1_3 1_11957799_T_G / 1_11958607_A_C / 1_11949823_T_G 0.016423562694112787 / 0.0001256608005905079 / 0.00021455234639659347 0.008642421166450967 / 0.04289731210522306 / 0.033198246352540164
107 ZBTB40_2 1_22508509_T_G / 1_22490438_G_C 0.019306644087308318 / 0.0028404969140742 0.007412910007401148 / 0.034427044070664166
108 LAMB1_4 7_107937003_CT_C / 7_107937011_T_C / 7_107932321_G_T / 7_107962914_G_C 0.02001404015878396 / 0.03127808008490267 / 2.518001172595479e-05 / 0.001938778625683203 0.0036685711722291453 / 0.0056496711183904105 / 0.008417008915963444 / 0.03562871053322305
109 ZNF407_2 18_74635526_T_C / 18_74631665_A_C 0.02054827360868693 / 0.0027671214071800644 0.0030145474545959137 / 0.0007578348015755224
110 PLK2_2 5_58457156_TA_T / 5_58459186_CA_C 0.02678606136810066 / 0.011492772698233265 0.0067079016563832035 / 0.009712841903254471
111 ITGAV_6 2_186622542_G_T / 2_186637080_T_G / 2_186637084_A_G / 2_186602110_C_T / 2_186665096_ATTT_A / 2_186665096_ATTT_AT 0.02893229553935201 / 1.7690277512995773e-05 / 5.7650114136378393e-05 / 0.0008794014178128033 / 0.0009612996704148748 / 0.0001992070205841996 0.0007084667177580308 / 0.001139110475330106 / 0.032143834630956734 / 0.02901306245899837 / 0.02901306245899837 / 0.044847327779240435
112 TPP2_4 13_102649187_G_T / 13_102654868_C_T / 13_102663598_G_C / 13_102663763_G_A 0.03448812010250688 / 0.0477208297438401 / 0.019367023504440688 / 0.03879139461694567 0.0003388682906380855 / 0.0002674729630147893 / 5.0196213345567326e-05 / 0.0001694198597404117
113 EGFR_2 7_55205133_G_A / 7_55205662_A_C 0.03713506709789649 / 0.0018125796749231603 0.003745674667154008 / 0.0007797573368817686
114 FAM57A_2 17_733080_T_TCTC / 17_733026_A_AGGGCC 0.039798318296646464 / 0.015321230586696297 0.00016240672631849488 / 4.5958865963508443e-05
115 RBFOX1_2 16_7676807_A_C / 16_7653705_T_G 1.089283918433845e-06 / 0.009933638723622762 0.017746981967786752 / 0.040139058541755146
116 PLEC_10 8_143935900_T_G / 8_143916360_A_G / 8_143917054_T_G / 8_143917234_T_G / 8_143918739_A_C / 8_143919099_A_G / 8_143925385_A_C / 8_143919088_C_G / 8_143927138_G_A / 8_143930017_C_T 1.2060887811693293e-09 / 0.0045339553290741135 / 0.000104533588224814 / 1.7757593439950334e-05 / 0.00011641011921845986 / 1.9686417676937634e-05 / 0.006102754107095385 / 0.01695040934478527 / 0.039180192965724406 / 0.017591680187249745 0.0004960012901022363 / 0.00910116635228719 / 0.025072704488480143 / 0.013279688389245713 / 2.138708286444241e-05 / 0.0010288222361061275 / 0.0062995698781779215 / 0.009415988048366521 / 0.008162873576760793 / 0.001268625363946227
117 ACTN1_2 14_68904620_A_G / 14_68879945_C_A 2.2790061519900746e-05 / 0.002826959920374089 0.01924890787722053 / 0.03820518094606298
118 YES1_2 18_724697_A_C / 18_732727_A_G 2.3090624801719088e-05 / 0.007129044591559579 0.008883311549914912 / 0.026256278963938562
119 SMARCC1_2 3_47662444_T_G / 3_47735913_C_T 2.3383243293118917e-06 / 0.002421910157609216 0.0017680794934126945 / 0.01814701077813162
120 LMNA_2 1_156139242_AT_A / 1_156138783_A_G 2.3951192128687798e-05 / 0.0022551444971150103 0.04237931129547261 / 0.040758441980734486
121 CCND1_2 11_69650913_A_G / 11_69651969_C_G 2.86821845503723e-06 / 0.0004216841283241181 0.024298615321604846 / 0.021515769887785408
122 SMARCA4_3 19_11025539_C_G / 19_11025639_C_T / 19_11059900_G_C 3.0403566208171576e-05 / 9.60336281664007e-06 / 0.00028978302130045137 0.00029624992802644123 / 0.02706216606857304 / 0.035243495124704975
123 KMT2C_7 7_152273692_G_A / 7_152235860_C_T / 7_152145265_T_G / 7_152152848_C_A / 7_152177504_T_G / 7_152236218_G_A / 7_152152869_A_G 4.1091183934080156e-05 / 0.03814263508657298 / 0.010803753158495692 / 0.018128565763915704 / 0.001183790631102062 / 0.008327722660599219 / 0.017441444102837326 0.02044755694417402 / 0.00015664974968742393 / 0.0030671124260532785 / 0.00028670765106413883 / 0.0007976241891358237 / 0.0009326888762057726 / 0.008191480303636886
124 PXN_2 12_120219856_A_C / 12_120219864_A_C 4.578278108445838e-05 / 0.0074220837424624425 0.0003630643828121584 / 0.0023389819820739933
125 BCOR_2 X_40052275_A_C / X_40074609_T_G 4.939704915952993e-09 / 0.0027449638737320047 0.00020414397606395237 / 0.02744186131378764
126 FLI1_2 11_128810729_A_G / 11_128810736_G_C 5.306393173162265e-05 / 0.004212940238900314 1.6562593178924343e-05 / 1.4658089385344776e-05
127 LAMB2_4 3_49121431_A_C / 3_49126013_T_G / 3_49125146_T_G / 3_49121239_T_G 5.5170807525836925e-05 / 0.03902097870402451 / 7.419230761410297e-05 / 0.003164093062093864 2.9470349723526757e-05 / 0.002569958840604656 / 0.002569958840604656 / 0.028556312248339717
128 HMGA2_2 12_65841991_CT_C / 12_65838525_G_A 5.57550946086e-05 / 0.039914434884169736 0.032926686839147117 / 0.00575414262140414
129 ZNF708_3 19_21294577_C_T / 19_21309149_T_A / 19_21309260_G_A 5.694223127781568e-05 / 9.010844850080123e-06 / 0.0003481251422158083 0.007544201865148675 / 0.008126720123629898 / 4.891895383413758e-05
130 ASPH_2 8_61578734_T_G / 8_61578968_A_C 6.56790692451237e-08 / 0.0009758798617439217 0.00027481062695969863 / 0.0029272870469332557
131 CCAR1_5 10_68737016_C_A / 10_68736998_A_C / 10_68747386_A_C / 10_68749170_A_C / 10_68747145_CT_C 8.229773536774104e-06 / 0.007146867657347806 / 0.0011117731660420908 / 0.0013852137674061765 / 0.003664158474067453 0.003954046326130957 / 0.005283569468845993 / 0.002868590533518923 / 0.044268019704288585 / 0.007417608363424872
132 DOCK1_3 10_127008567_ATAACT_A / 10_127248024_G_T / 10_127414990_T_G 9.077419985352092e-05 / 0.0002745710836507499 / 0.00705137247255559 0.0011610761862802675 / 0.020184142497530616 / 0.047170945666414485
[표 17]에는 EGFR 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 17]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 39에는 [표 17]에 기재된 바이오마커들 중 주요 바이오마커들의 EGFR 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
EGFR 약물에 대한 반응성 바이오 마커 및 약물과의 반응성 검증 결과
No. FRH Variants(마커) Var_Drug(pval) Var_Exp(Pval)
1 CWC27_1 5_64977191_G_A 2.20E-08 0.002090721
2 RNF217_1 6_125082793_A_C 3.96E-08 0.0374208
3 PTGR1_1 9_111597344_C_A 8.25E-08 2.15E-05
4 NTN4_1 12_95738117_A_G 1.53E-07 0.019702457
5 ZNF276_1 16_89737928_T_C 1.72E-07 0.019670045
6 THBS1_1 15_39587486_A_C 2.59E-07 0.031233094
7 TRIM29_1 11_120115474_C_A 3.52E-07 0.011023929
8 APBB1_1 11_6401118_A_C 7.48E-07 0.04449344
9 RASA3_1 13_113981629_G_A 1.35E-06 0.009453296
10 TMX3_1 18_68700489_TA_T 1.39E-06 0.003224589
11 RRP1_1 21_43791417_C_A 1.65E-06 0.034182877
12 SIT1_1 9_35650461_G_A 1.75E-06 0.019947873
13 FRG1_1 4_189955114_T_C 2.25E-06 0.018901776
14 GTF2IRD1_1 7_74512993_A_G 3.54E-06 0.006481631
15 DCP1A_1 3_53342054_G_C 4.78E-06 0.003471409
16 SNRNP70_1 19_49101556_A_C 5.20E-06 0.016599779
17 DDX20_1 1_111756207_T_C 5.26E-06 0.008003234
18 TJP2_1 9_69237088_T_C 5.58E-06 0.04386431
19 RHOJ_1 14_63269236_T_G 6.18E-06 0.027885215
20 CXCL2_1 4_74098975_A_C 7.13E-06 0.000838562
21 CARD8_1 19_48212012_T_C 9.03E-06 0.00020501
22 TRMT2A_1 22_20117296_A_C 9.03E-06 0.048556634
23 CRIM1_1 2_36479368_G_C 9.53E-06 0.012444715
24 ELF3_1 1_202010991_C_G 9.65E-06 0.017391595
25 UHRF2_1 9_6482002_G_T 1.20E-05 0.007025127
26 HDHD2_1 18_47115026_C_T 1.42E-05 1.48E-06
27 ZBTB17_1 1_15944765_G_A 1.47E-05 0.010171388
28 THRB_1 3_24143504_G_A 1.80E-05 0.026515077
29 DHRS3_1 1_12568430_G_A 1.81E-05 0.043238329
30 AGTPBP1_1 9_85672687_TA_T 1.94E-05 0.017580094
31 DMTF1_1 7_87166631_TAG_T 1.97E-05 0.010040428
32 CTBP2_1 10_124993226_T_G 2.02E-05 0.022707139
33 BLK_1 8_11543171_G_A 2.24E-05 0.01145612
34 EPCAM_1 2_47373742_AT_A 2.57E-05 0.033377716
35 JUN_1 1_58782229_T_C 2.65E-05 0.037758558
36 RBM5_1 3_50114164_G_T 2.77E-05 0.00111984
37 CDKN2AIP_1 4_183445476_T_TGCACA 2.77E-05 0.002734488
38 ZCCHC7_1 9_37302158_C_T 2.93E-05 0.022389727
39 RAB8B_1 15_63262625_GTA_G 2.96E-05 0.020562837
40 ODC1_1 2_10444350_A_C 2.98E-05 0.031377929
41 CLTB_1 5_176397682_T_C 3.11E-05 0.006127908
42 UIMC1_1 5_176906125_C_T 3.66E-05 0.014840456
43 HCST_1 19_35903545_A_C 3.71E-05 0.031562304
44 HSPA1B_1 6_31828722_C_G 3.82E-05 0.018774385
45 MYL12B_1 18_3261766_G_T 4.16E-05 0.002628021
46 RHBDF1_1 16_63885_G_GCC 4.21E-05 0.04101508
47 UBE2N_1 12_93411182_C_T 4.29E-05 1.51E-06
48 SVIL_1 10_29524582_A_G 4.44E-05 0.010981597
49 CCDC28B_1 1_32202026_A_C 4.45E-05 0.031117706
50 ADARB1_1 21_45182568_CT_C 4.48E-05 0.049945862
51 PPP4R1_1 18_9549876_A_G 5.09E-05 0.004893788
52 CHD1L_1 1_147294440_C_G 5.10E-05 0.048656291
53 LRP5_1 11_68424878_T_G 5.20E-05 0.010363624
54 RND3_1 2_150487464_GA_G 5.77E-05 0.009852344
55 LONRF1_1 8_12731670_C_A 5.98E-05 0.001411904
56 BCOR_1 X_40052275_A_C 6.09E-05 0.000204144
57 CCT8_1 21_29070160_C_T 6.54E-05 0.02571665
58 ZNF330_1 4_141232702_CTT_C 8.61E-05 0.012329326
59 CEP128_1 14_80916501_C_A 8.82E-05 0.001156052
60 SH2D3A_1 19_6760997_A_G 9.99E-05 0.028745239
61 IRF6_1 1_209790735_C_T 0.000103095 0.008136801
62 ITGAL_1 16_30484175_C_T 0.000109049 0.037227837
63 UEVLD_1 11_18558312_C_A 0.000112934 0.026771319
64 RNF141_1 11_10530725_T_C 0.000116417 0.011923468
65 THRAP3_1 1_36288866_G_C 0.000117571 0.000131738
66 PIAS4_1 19_4028785_C_T 0.000120052 0.024864531
67 SLC22A5_1 5_132390655_C_A 0.000123083 0.004292176
68 JAG1_1 20_10648877_T_C 0.00012714 0.02148436
69 SPI1_1 11_47358510_A_C 0.000133865 0.03491009
70 TECPR1_1 7_98223587_A_G 0.000136841 0.023100583
71 ZC3HC1_1 7_130023656_C_T 0.000136956 0.010175357
72 PDGFA_1 7_518698_G_C 0.000139135 0.000252407
73 C16orf74_1 16_85741569_G_A 0.000148491 0.001823033
74 DOT1L_1 19_2226677_G_A 0.00015451 0.006191812
75 CD19_1 16_28937656_A_C 0.000155088 0.031114669
76 P2RY2_1 11_73235099_G_C 0.000158117 0.045669577
77 EHF_1 11_34661000_T_C 0.000158117 0.017992198
78 EPS15L1_1 19_16392488_A_C 0.000158117 0.033272384
79 AGTRAP_1 1_11750007_T_G 0.000159275 0.049159238
80 LYRM7_1 5_131199511_CT_C 0.000164473 0.021278948
81 EPAS1_1 2_46346944_T_G 0.000170063 0.018667654
82 SIX4_1 14_60713618_C_T 0.000180476 0.049844478
83 PROM2_1 2_95281185_T_G 0.000190311 0.033838771
84 CAPN1_1 11_65186241_T_G 0.000194914 0.02936405
85 SRRM1_1 1_24669380_C_A 0.000202713 0.019718891
86 KLF3_1 4_38689006_A_C 0.000228896 0.015121455
87 THSD4_1 15_71765130_A_C 0.000239788 1.95E-06
88 GPR107_1 9_130129853_A_G 0.000243505 0.033022802
89 TCERG1_1 5_146471685_A_C 0.000246294 0.042046343
90 ATG4C_1 1_62805167_G_T 0.000259178 0.028589986
91 SHQ1_1 3_72750552_C_T 0.000259737 0.005940284
92 DSG2_1 18_31524751_A_G 0.000261765 0.009944093
93 S100A14_1 1_153615226_C_T 0.000274681 0.01787459
94 CLDN4_1 7_73830773_C_T 0.000293995 0.000682466
95 OVOL2_1 20_18041767_A_G 0.000295117 0.047118131
96 CREB1_1 2_207577759_AT_A 0.00029854 0.000463006
97 BCLAF1_1 6_136278266_T_C 0.000301864 6.60E-05
98 PKP2_1 12_32791480_G_T 0.000343509 0.006486331
99 ADAM9_1 8_39082624_ATTT_A 0.000344695 0.022961
100 POLA1_1 X_24743203_T_G 0.000351661 0.028975018
101 FBXO10_1 9_37537560_G_A 0.000376887 0.024540631
102 CHMP4B_1 20_33811394_C_G 0.000388769 0.00409862
103 NOP56_1 20_2657708_GT_G 0.000405654 0.000313483
104 WIPF1_1 2_174585550_T_G 0.000407518 0.000483959
105 SCNN1A_1 12_6349108_G_C 0.00042455 0.003465155
106 C11orf80_1 11_66828178_C_T 0.000427492 0.010017428
107 ERP27_1 12_14914577_T_TGTGC 0.000433389 0.018734323
108 JAG2_1 14_105151295_T_G 0.000452695 0.00756224
109 SMARCC1_1 3_47693210_A_G 0.00046021 6.92E-05
110 RNF138_1 18_32123591_T_C 0.000469129 0.018606829
111 THYN1_1 11_134248640_G_T 0.000477172 0.042214253
112 CYP24A1_1 20_54164725_T_C 0.000480706 0.013922674
113 SH2D3C_1 9_127766923_A_C 0.000489816 0.042455713
114 TGFA_1 2_70453242_T_G 0.000497539 0.011508647
115 CXCL16_1 17_4738773_T_G 0.000507631 0.000457547
116 AEN_1 15_88629905_A_C 0.000523617 0.014580971
117 SLC37A1_1 21_42534616_T_G 0.00054592 0.025393921
118 EPHA2_1 1_16148437_A_C 0.000564393 0.003022958
119 BCS1L_1 2_218660859_A_G 0.000567546 0.011564609
120 FBXO43_1 8_100137711_G_C 0.000602338 0.026281824
121 ADAM22_1 7_88075657_C_T 0.000632153 0.041287227
122 ADAMTSL1_1 9_18636052_G_T 0.000649915 0.010200615
123 ATXN2L_1 16_28834263_C_T 0.000652099 0.023519932
124 ZCCHC4_1 4_25313024_A_C 0.000669769 0.022993547
125 BCL2_1 18_63318646_T_C 0.000676626 0.021320439
126 EGR1_1 5_138466811_A_C 0.000686817 0.000273933
127 HS3ST1_1 4_11399218_T_C 0.000704542 0.027639734
128 LEF1_1 4_108078210_G_A 0.000716837 0.012727304
129 SRSF7_1 2_38748190_GT_G 0.000734347 0.005863144
130 KHSRP_1 19_6415784_T_C 0.000787917 0.003576751
131 YPEL1_1 22_21704297_T_C 0.000796764 0.006311112
132 TAPT1_1 4_16162866_G_A 0.000802167 0.000763967
133 SNRK_1 3_43348277_C_T 0.000817875 0.00952899
134 UGCG_1 9_111932206_A_G 0.000846657 0.012775358
135 DBF4B_1 17_44709262_G_C 0.000856709 0.025236345
136 HOOK1_1 1_59860373_C_G 0.000856894 0.041888498
137 ITGB3BP_1 1_63572436_G_T 0.000871324 0.023830002
138 DTX4_1 11_59205028_T_C 0.000886385 0.025332013
139 PPP1R13L_1 19_45391868_T_C 0.000894105 0.005877508
140 CBLC_1 19_44790103_A_C 0.000937082 0.025305244
141 B4GALT4_1 3_119212822_G_T 0.000987069 8.97E-06
142 HSBP1_1 16_83809462_C_T 0.000990234 0.008673739
143 DTX1_1 12_113093500_A_T 0.001029524 0.02107386
144 TMEM51_1 1_15219789_A_C 0.001061315 0.004570596
145 ASAP2_1 2_9388476_A_C 0.001065564 0.013740425
146 PPP2R3C_1 14_35096667_C_A 0.001070573 0.008848084
147 WWC2_1 4_183280995_G_T 0.001131955 0.017164588
148 DMKN_1 19_35505819_C_T 0.001187435 0.023762682
149 EPHX1_1 1_225838589_T_G 0.001193048 0.015600736
150 PRPF4B_1 6_4051933_C_A 0.001231599 0.023843897
151 SNRNP40_1 1_31267793_A_G 0.001239539 0.0334327
152 LTBP3_1 11_65543062_T_C 0.00124246 0.027887632
153 BAG3_1 10_119651803_A_C 0.001254787 0.031179453
154 ANKRD2_1 10_97572685_T_G 0.001261251 0.014732168
155 ZNF451_1 6_57147971_C_A 0.001263762 0.000340137
156 ME2_1 18_50920583_C_T 0.00130336 2.53E-06
157 DLG5_1 10_77811963_T_G 0.001305738 0.016910687
158 USP19_1 3_49111457_T_C 0.001383111 0.008511689
159 PDCD11_1 10_103433899_A_G 0.001419074 0.023046171
160 PDE1B_1 12_54577030_T_G 0.0014774 0.000907902
161 LONP1_1 19_5707040_C_G 0.001478061 0.014919269
162 KCNN3_1 1_154733143_A_C 0.001483801 0.012755172
163 FSD1_1 19_4304543_G_C 0.001495716 0.036857163
164 F2RL1_1 5_76832874_T_G 0.001535054 0.000269192
165 XPO4_1 13_20787374_T_C 0.001546207 0.044182604
166 TM4SF1_1 3_149375342_T_G 0.001551483 0.005766355
167 NPAS1_1 19_47035965_T_G 0.001567313 0.037858765
168 FAM78A_1 9_131260861_G_A 0.001574494 0.029873205
169 SYTL2_1 11_85734802_A_C 0.001576085 0.007792297
170 TMEM57_1 1_25431052_T_G 0.001577095 0.001041181
171 TUBA1A_1 12_49186397_T_C 0.001584541 0.019746043
172 ITPR3_1 6_33692820_C_T 0.001625448 0.001333145
173 ATM_1 11_108317650_T_C 0.001633198 0.007926126
174 SGTA_1 19_2769109_A_C 0.001653712 0.041785185
175 LCORL_1 4_17883673_A_AAC 0.001662772 0.000314326
176 MTDH_1 8_97660911_G_GATA 0.001694886 0.048360283
177 IKBKB_1 8_42320656_T_C 0.00170984 2.52E-05
178 HNRNPD_1 4_82355277_C_CA 0.001737277 0.049911299
179 RAX_1 18_59272671_A_C 0.001739655 0.028250861
180 ZNF775_1 7_150397902_A_C 0.001751147 0.01910485
181 ALDH1A3_1 15_100885169_T_G 0.001758148 0.04003907
182 GNAI2_1 3_50252193_A_C 0.001785905 0.005183043
183 ZNF740_1 12_53187645_C_G 0.001788461 0.049202233
184 NTM_1 11_132307846_G_T 0.001796239 0.000193861
185 CHN1_1 2_174801578_A_G 0.001797358 0.038050415
186 PAX5_1 9_36923611_G_A 0.001934236 0.014759026
187 VAMP3_1 1_7781489_A_C 0.00200626 0.040313352
188 STK4_1 20_44995009_C_T 0.002049488 5.24E-05
189 USP24_1 1_55075675_C_A 0.002073268 0.008980628
190 EXOSC10_1 1_11080567_C_A 0.002083377 0.019692529
191 TINAGL1_1 1_31585380_T_G 0.002085646 0.037138102
192 SPTLC3_1 20_13093456_G_T 0.002145546 0.024467108
193 PLEKHA6_1 1_204257921_A_C 0.002162143 0.049362899
194 PLXNC1_1 12_94219931_T_G 0.002163508 0.043558201
195 CAPN2_1 1_223717830_G_A 0.0022465 0.020893773
196 TJP1_1 15_29718124_TA_T 0.002277416 0.026903818
197 ASPHD2_1 22_26442326_G_A 0.002296851 0.029916144
198 IFT43_1 14_76082206_T_G 0.002305612 0.012552105
199 CASK_1 X_41578463_T_G 0.002309184 0.043343775
200 C21orf33_1 21_44144829_C_T 0.002316139 0.047114252
201 AFAP1L2_1 10_114294856_CCTAA_C 0.00232372 0.037962739
202 MEI1_1 22_41699656_A_C 0.002354824 0.019192604
203 HAUS6_1 9_19080551_G_A 0.002357763 0.027262757
204 LRRC8E_1 19_7899842_G_A 0.002381607 0.011668019
205 SMARCB1_1 22_23787366_GGC_G 0.002396307 0.000127894
206 DUT_1 15_48332272_A_C 0.002405318 0.00018263
207 MON1A_1 3_49911902_A_G 0.002439566 0.010543368
208 SASH1_1 6_148440274_CT_C 0.002448515 0.046157021
209 MAP1S_1 19_17726640_A_C 0.002527497 0.022464441
210 TOE1_1 1_45340381_G_A 0.002528538 0.048016234
211 CNOT7_1 8_17242848_C_T 0.002530932 7.40E-11
212 CD244_1 1_160836124_G_A 0.002583957 0.026316972
213 EPM2AIP1_1 3_36992730_A_C 0.002610713 0.00113706
214 PRSS16_1 6_27249457_C_T 0.002649855 0.041003068
215 GPSM3_1 6_32192179_T_C 0.002655487 0.017253689
216 UGDH_1 4_39527132_G_A 0.002672816 0.035973223
217 AIG1_1 6_143060973_T_C 0.002697343 0.001184612
218 PMS1_1 2_189864380_G_A 0.002709035 0.028805775
219 PTGFR_1 1_78497752_G_A 0.002814073 0.008690688
220 AGPAT2_1 9_136674614_A_G 0.002858165 0.022967509
221 CBL_1 11_119278299_T_G 0.002995636 0.015544213
222 RAB37_1 17_74694690_G_A 0.003050869 0.017656336
223 GTPBP3_1 19_17338111_A_C 0.003059974 0.000709713
224 HDAC4_1 2_239053232_A_C 0.003067942 0.036469606
225 MBD3_1 19_1577118_C_T 0.003069952 0.001822739
226 CEP170_1 1_243164906_G_A 0.003157617 0.005533907
227 S100A16_1 1_153607964_A_G 0.003160582 0.026054854
228 DCK_1 4_71022615_CT_C 0.003222902 0.021365647
229 INF2_1 14_104713013_A_C 0.003224544 0.022440089
230 MYO6_1 6_75870526_T_C 0.003249199 0.022167818
231 CDS1_1 4_84635369_T_A 0.003299427 0.032630939
232 CTDSPL_1 3_37980672_C_T 0.003333659 0.043268165
233 EPB41L1_1 20_36187855_G_T 0.003410098 0.042407864
234 FGR_1 1_27617489_T_A 0.003443717 0.014581374
235 CAPRIN1_1 11_34051813_A_G 0.003553009 0.001206062
236 FOXC1_1 6_1612184_TA_T 0.00358795 0.004712911
237 ARHGEF6_1 X_136685627_G_A 0.003598733 0.001837929
238 BCAR3_1 1_93674923_G_C 0.003606528 0.049870881
239 BCL9L_1 11_118897861_A_C 0.003681075 0.034238861
240 TMEM201_1 1_9610425_T_A 0.003707837 0.025977963
241 RPS11_1 19_49496985_C_T 0.003720736 0.048243831
242 GMEB1_1 1_28690201_G_T 0.003734863 0.005247117
243 XRCC5_1 2_216109182_G_C 0.00380529 0.019360584
244 IL13RA1_1 X_118776541_G_T 0.003874528 0.009303333
245 PRR14_1 16_30651924_T_G 0.003882844 0.041861928
246 SH2B3_1 12_111418260_C_G 0.003991404 0.00753988
247 DTNBP1_1 6_15662698_A_G 0.00400197 0.006306033
248 PADI1_1 1_17228910_T_G 0.004006843 0.013302935
249 FAF1_1 1_50787989_A_G 0.004030148 0.030848308
250 RAB11FIP5_1 2_73075763_G_GGCCT 0.004085081 0.024778824
251 ZBTB40_1 1_22508509_T_G 0.004115308 0.00741291
252 BLCAP_1 20_37517746_T_C 0.004121218 0.011965638
253 KIF2A_1 5_62373627_T_G 0.004150384 0.036674489
254 HCFC1_1 X_153963207_T_G 0.004154957 0.001579155
255 HINFP_1 11_119121467_T_C 0.004250524 0.04539997
256 PRDM2_1 1_13823349_T_A 0.004303676 0.011003429
257 EIF4E_1 4_98902074_AT_A 0.004333629 0.008214508
258 PARVG_1 22_44206294_C_G 0.004424 0.028583204
259 COX18_1 4_73064835_G_A 0.004489575 0.009081073
260 WDR33_1 2_127701640_C_G 0.004497758 0.006721664
261 ARHGAP9_1 12_57474460_G_A 0.004523019 0.041357487
262 GGCX_1 2_85550432_A_G 0.004614743 0.015128917
263 ZNF182_1 X_47983350_T_G 0.004661316 0.045101518
264 ANXA6_1 5_151117292_C_T 0.004727288 0.038173193
265 RPL14_1 3_40457950_G_A 0.004955666 0.001218496
266 FCHO2_1 5_73082876_ATT_A 0.004962427 0.029256929
267 RAB28_1 4_13473790_TATC_T 0.004968595 0.040901005
268 RNGTT_1 6_88769645_C_T 0.00502562 0.002545266
269 NNT_1 5_43602611_T_C 0.005081886 0.030151517
270 CLDN1_1 3_190308594_C_T 0.005105908 0.019956392
271 NRN1_1 6_6003752_C_T 0.005133833 0.006175355
272 ZNF423_1 16_49635837_A_C 0.005155281 0.015077717
273 YES1_1 18_732727_A_G 0.00519113 0.026256279
274 RAPGEF6_1 5_131433731_GA_G 0.005213959 0.0053626
275 MGAT4B_1 5_179799918_A_G 0.005262946 0.044186289
276 GATAD2B_1 1_153818250_T_C 0.005279052 0.026743921
277 FCRL5_1 1_157518564_T_C 0.005397526 0.023539142
278 ACSS2_1 20_34925819_A_C 0.00560253 0.016776881
279 CTR9_1 11_10773884_CAAAAA_C 0.005625384 0.03664895
280 INPP5B_1 1_37872885_G_T 0.005738649 0.010365859
281 RPAIN_1 17_5421266_TTC_T 0.005740177 0.041469888
282 RCHY1_1 4_75509142_T_A 0.00575286 7.00E-06
283 RASSF7_1 11_562335_A_C 0.005935904 0.018138357
284 NKX3-2_1 4_13541263_A_G 0.00596504 0.000419444
285 IGFBP3_1 7_45917562_GT_G 0.006141827 0.045400401
286 LTBR_1 12_6385217_T_C 0.006192879 9.81E-05
287 GNG2_1 14_51950694_A_C 0.006226032 0.02637487
288 NAP1L1_1 12_76084896_T_C 0.006264126 0.018182577
289 GULP1_1 2_188589974_C_CT 0.006362476 0.004507263
290 PXDC1_1 6_3727577_C_G 0.006364895 0.027367829
291 WDR12_1 2_202897546_T_A 0.006402216 0.044170968
292 TMBIM6_1 12_49742405_G_A 0.006435087 0.019471463
293 PPM1D_1 17_60656452_CA_C 0.006580355 0.01692061
294 RPA2_1 1_27907061_GA_G 0.006586873 0.02798096
295 PRR3_1 6_30562126_T_G 0.006592704 0.005676599
296 RBM28_1 7_128310614_C_A 0.006924451 0.019795754
297 ENAH_1 1_225519569_GAAAA_G 0.007036997 0.048924277
298 KIAA0922_1 4_153592379_A_G 0.0070597 0.048688528
299 TRIM2_1 4_153276097_A_G 0.007183471 0.011894098
300 ATP8B1_1 18_57731374_T_C 0.007320467 0.035819404
301 QSOX1_1 1_180178802_A_G 0.007420273 0.008203943
302 MB_1 22_35607296_C_G 0.007592955 0.045421658
303 ORAI2_1 7_102433548_G_A 0.007786599 0.035889292
304 WNT7B_1 22_45931386_G_A 0.007831858 0.025701725
305 PIKFYVE_1 2_208330748_GT_G 0.007852983 0.009816454
306 ARHGAP32_1 11_128972609_T_G 0.007895267 0.007875634
307 SH3YL1_1 2_249571_C_T 0.007939764 0.043096755
308 DEPDC5_1 22_31843912_CT_C 0.00801665 0.025230811
309 VSIG10_1 12_118073908_T_G 0.008024404 0.001976122
310 SLX4_1 16_3595722_A_C 0.008031231 0.013087513
311 REEP3_1 10_63621980_A_G 0.008035335 0.03021965
312 FARSB_1 2_222571709_T_C 0.00812224 0.037339824
313 NDUFS3_1 11_47578800_A_G 0.00843631 0.008511324
314 HIBADH_1 7_27538786_G_A 0.008437431 0.025866827
315 SCLT1_1 4_128957191_A_C 0.008485976 0.015508556
316 SLC20A2_1 8_42439475_C_T 0.008560526 0.001296999
317 LMO7_1 13_75855483_C_A 0.008616687 0.000790188
318 SREBF2_1 22_41897136_G_C 0.008665061 0.031235978
319 SPAG1_1 8_100194395_C_A 0.008766072 0.025833604
320 NCAM1_1 11_113270137_A_G 0.008796809 0.040540565
321 ATP1B1_1 1_169111407_C_G 0.008822814 0.015890801
322 PLXNB2_1 22_50281752_C_G 0.008850507 0.048268974
323 PFAS_1 17_8269414_A_G 0.008856682 0.026137416
324 CEP152_1 15_48762574_G_C 0.008866418 0.044026406
325 GNRH1_1 8_25423267_A_G 0.009056061 0.039449902
326 CARD10_1 22_37508612_T_C 0.009110799 0.021324272
327 COL6A3_1 2_237351090_T_G 0.00914922 0.009459532
328 RBM12B_1 8_93733158_G_T 0.009183374 0.012443278
329 ITPKC_1 19_40737666_A_C 0.009205546 0.045257656
330 ARHGAP31_1 3_119390922_C_T 0.009221747 0.042725387
331 GRAMD1A_1 19_35022992_C_T 0.00930255 0.030347265
332 SAE1_1 19_47131056_T_G 0.009443122 0.006083296
333 MICALL1_1 22_37924607_T_G 0.009460572 0.025017274
334 GABRB2_1 5_161336809_G_A 0.009484795 0.019276169
335 SPINT2_1 19_38287977_A_G 0.009500965 0.018521267
336 ATXN7_1 3_63990247_A_C 0.009623217 5.97E-05
337 TATDN2_1 3_10248824_C_CT 0.009659313 0.000116552
338 AP4E1_1 15_50968319_T_G 0.009752147 0.046599506
339 CHST2_1 3_143121243_A_G 0.009892538 0.040099833
340 PRKAG2_1 7_151560579_A_G 0.009896448 0.024618763
341 C16orf45_1 16_15596596_T_G 0.009927037 0.04351851
342 SULT2B1_1 19_48591514_T_G 0.009943382 0.006727275
343 DSTN_1 20_17600864_A_G 0.009947784 0.000427203
344 TPD52L2_1 20_63889961_A_C 0.010191021 0.005896198
345 E2F2_1 1_23521217_C_G 0.010495212 0.008957912
346 TSEN34_1 19_54192354_T_G 0.010854598 0.001848481
347 FOXN3_1 14_89162512_A_C 0.011014558 0.001249668
348 MND1_1 4_153408912_G_GTATATA 0.011263008 0.006400349
349 ZDHHC5_1 11_57696028_T_C 0.01129582 0.000204877
350 ARMCX4_1 X_101488321_C_G 0.011422104 0.008157752
351 P2RY11_1 19_10115376_G_A 0.011466091 0.000105991
352 C1orf198_1 1_230839028_T_C 0.011890625 0.008759206
353 TPTE2_1 13_19425773_G_A 0.011929579 0.00812417
354 TMEM206_1 1_212379769_G_C 0.01195192 0.000739419
355 REEP5_1 5_112891583_T_A 0.012573055 0.001996089
356 CNNM4_1 2_96798981_T_G 0.012933399 0.000393837
357 GPR65_1 14_88011069_C_T 0.013002947 0.005376071
358 ZDHHC7_1 16_84981848_T_G 0.013133304 0.007398316
359 KCNAB3_1 17_7925552_G_A 0.013376003 0.008474756
360 ASNSD1_1 2_189670812_C_T 0.013663903 0.004106264
361 LY9_1 1_160814485_A_C 0.014209114 0.004017681
362 SKIV2L2_1 5_55307994_T_C 0.01489715 0.008290134
363 MADD_1 11_47325027_T_C 0.01504914 0.001497343
364 ITPRIPL1_1 2_96325641_T_G 0.0151793 0.004828474
365 SDC4_1 20_45330303_T_G 0.015973482 0.000496261
366 SLC2A8_1 9_127398490_G_A 0.016168742 0.003968261
367 CSF2RB_1 22_36923285_A_C 0.016450302 0.008060727
368 WWTR1_1 3_149669685_C_T 0.016674011 0.040303211
369 PEX10_1 1_2410431_A_C 0.017756279 7.19E-05
370 SCMH1_1 1_41033845_T_G 0.01786284 0.006455807
371 WNT10A_1 2_218882471_A_C 0.018148757 0.008633339
372 SIRT4_1 12_120303510_G_GAA 0.018478224 0.002426212
373 SLC25A43_1 X_119451980_A_G 0.018546868 0.000927303
374 SLC35F5_1 2_113723196_TA_T 0.019332514 0.009792442
375 PLEKHA5_1 12_19369550_A_AAAAG 0.019740309 0.004535622
376 RASEF_1 9_82982805_CAGAG_C 0.019798987 5.81E-06
377 RASSF2_1 20_4797919_T_G 0.019937429 0.007153311
378 ANKRD44_1 2_197099965_G_A 0.020081182 0.009634061
379 ZFYVE19_1 15_40812591_A_AAG 0.020142634 0.000177529
380 TMEM2_1 9_71704688_T_G 0.02064031 0.00528138
381 TMEM159_1 16_21174063_G_A 0.020994925 0.001734513
382 PEX13_1 2_61045783_A_T 0.021004523 0.005293964
383 BCAR1_1 16_75229126_T_A 0.021029307 0.004775721
384 SLC25A38_1 3_39389590_G_A 0.021402491 5.21E-05
385 ING5_1 2_241711916_A_C 0.021779734 0.000297693
386 AHR_1 7_17339074_A_C 0.021825994 0.009928124
387 ETV1_1 7_13900838_A_C 0.022234699 0.00028392
388 FUS_1 16_31191353_T_G 0.022580325 0.000527105
389 ELMO1_1 7_36986095_A_C 0.022675843 0.000582138
390 FLI1_1 11_128772826_T_G 0.022696029 2.10E-08
391 RBPJ_1 4_26321137_C_A 0.023026755 0.005948758
392 TGM1_1 14_24260894_A_C 0.023877255 4.06E-05
393 MAD2L2_1 1_11680485_C_A 0.024343193 0.005401081
394 CCDC66_1 3_56613771_T_C 0.024734355 0.00694013
395 E2F3_1 6_20402547_A_C 0.024779926 0.001096854
396 TRIM47_1 17_75875198_A_C 0.025043777 0.006990418
397 LACTB2_1 8_70657773_A_C 0.025193805 0.000265188
398 S100A13_1 1_153619154_A_C 0.026872567 0.000285894
399 PRKCZ_1 1_2059508_T_G 0.027355157 0.000553783
400 KIAA0430_1 16_15601202_A_G 0.027767771 0.008344755
401 PARP1_1 1_226377365_T_C 0.028078591 0.000660394
402 VMP1_1 17_59841357_A_C 0.028144116 0.00700708
403 TRPM7_1 15_50619668_AT_A 0.028234282 0.007696192
404 RPL11_1 1_23695353_C_A 0.028842665 0.006999268
405 RHPN2_1 19_33002924_G_A 0.02894401 0.001694408
406 MAST3_1 19_18107675_A_T 0.028979003 0.002887665
407 SACS_1 13_23354711_A_C 0.029483838 0.007436264
408 ZBTB4_1 17_7463332_C_G 0.030579241 0.009123992
409 SSH3_1 11_67309455_A_C 0.031167208 0.006068708
410 STAU1_1 20_49153934_T_C 0.031695969 0.047157357
411 PRSS22_1 16_2853046_G_C 0.032478102 0.003660773
412 SRRD_1 22_26488073_G_A 0.03313164 0.001986837
413 ITGB8_1 7_20399120_C_G 0.033295835 0.000193939
414 FLII_1 17_18245630_C_G 0.033989678 0.00994433
415 TMEM40_1 3_12769284_C_T 0.034416268 0.003842868
416 SLC19A1_1 21_45512453_A_C 0.034642487 0.009916208
417 FBN1_1 15_48425289_G_T 0.035154355 0.007224526
418 TMC4_1 19_54160564_G_A 0.03557474 0.008695606
419 TACC2_1 10_122132454_G_A 0.036645036 7.09E-05
420 HEATR5A_1 14_31315848_T_C 0.037815962 0.000583004
421 SLC25A24_1 1_108161212_C_T 0.038139179 0.001625377
422 TMEM39B_1 1_32091713_A_C 0.038513492 0.008701631
423 ANKRD22_1 10_88831974_A_C 0.039475145 0.00796284
424 SFSWAP_1 12_131753058_C_G 0.039748632 0.004289964
425 C1orf54_1 1_150279750_G_C 0.039956255 0.001281485
426 SEPT10_1 2_109564377_G_T 0.040053757 0.00487648
427 FOS_1 14_75280999_A_C 0.04011469 0.001488063
428 AARS2_1 6_44301927_CAGG_C 0.041166243 0.004966986
429 EMP1_1 12_13211531_T_G 0.041461108 0.001600571
430 FBXO2_1 1_11648995_C_G 0.042445462 0.005932397
431 UBE3A_1 15_25408653_C_A 0.044428109 0.002080316
432 GPC1_1 2_240451007_T_G 0.044965723 0.007919222
433 ACTN4_1 19_38728028_T_G 0.045229843 0.005408687
434 EPB41L4B_1 9_109182980_T_C 0.045378555 0.002429073
435 SERTAD3_1 19_40441466_GGATC_G 0.045415799 0.001465832
436 WHSC1L1_1 8_38315857_G_C 0.046096872 0.004506209
437 QRICH1_1 3_49076524_TAAA_T 0.046339149 0.007356338
438 CAMSAP3_1 19_7618018_A_C 0.046801001 0.000416732
439 TCHP_1 12_109907472_T_G 0.047094137 0.003720466
440 TUFT1_1 1_151565936_G_A 0.048675231 0.004559558
441 CHMP1A_1 16_89649256_C_T 0.048695701 0.003804631
442 LAMB2_1 3_49125146_T_G 0.049754671 0.002569959
443 PNRC2_1 1_23961290_GCTT_G 0.049756672 0.006024417
444 MARVELD2_1 5_69419733_A_C 0.049786079 0.007668831
445 SLC22A18_3 11_2919250_T_G / 11_2903361_G_A / 11_2919268_T_G 0.00010006113410040524 / 0.0011537278855378685 / 0.03948380156101269 0.003253241739951185 / 0.009485355002003664 / 0.004588734004408302
446 SH3D19_3 4_151148254_TACACACACACACACAC_T / 4_151122202_T_C / 4_151148202_G_T 0.00010065962678441032 / 0.015768562077467373 / 0.0009087951468125592 0.016052772944150497 / 0.00026537095134489047 / 0.004030165987762314
447 LARS2_5 3_45474156_T_C / 3_45476267_G_A / 3_45488909_G_A / 3_45500591_T_C / 3_45417241_A_G 0.00010374784857743111 / 3.7424426310272928e-06 / 1.2434210249182578e-07 / 6.432927229497336e-08 / 0.004689576487598519 1.1453239774161183e-13 / 9.671821420877082e-13 / 6.257680298053254e-14 / 4.345853387032865e-14 / 0.022164736928693304
448 SRGAP1_2 12_64142411_T_C / 12_64097222_GTT_G 0.00010959539878441124 / 0.0011886231256692465 0.006505852651723906 / 0.02613509690642953
449 ALDH3A1_3 17_19742310_G_A / 17_19748298_C_T / 17_19740913_C_G 0.00011241479007533596 / 0.0023838380538555946 / 0.026511359318080838 0.016065461057378518 / 0.04852415829065191 / 0.0007153928676742558
450 LPIN3_5 20_41345676_A_G / 20_41358461_T_G / 20_41358465_C_G / 20_41340873_C_A / 20_41350009_T_G 0.00011710984250539265 / 0.000846270947552816 / 0.0063262440202536815 / 7.192100726008128e-05 / 0.033798727519866234 0.001902884670314011 / 5.712471333190794e-05 / 6.891802498643105e-05 / 0.025739865299148755 / 0.0036707505113827256
451 LAMB3_3 1_209626885_C_T / 1_209626996_C_T / 1_209630438_C_T 0.00012286163323842149 / 0.0001560650413956853 / 0.00010264198687506551 0.014463355479842403 / 0.005725629984184445 / 0.0254414675884508
452 RAC1_2 7_6398689_A_C / 7_6401802_T_G 0.00012312607987750062 / 0.022378677686989437 0.0005959472772163739 / 0.003141262984465143
453 CERKL_2 2_181603835_A_C / 2_181678048_T_G 0.00012332912254087272 / 0.00048702996607960313 8.976196985876391e-05 / 0.010552400468127526
454 MTO1_2 6_73492090_C_T / 6_73473277_C_CAGAT 0.0001242869571724915 / 0.027975699490295474 0.0009500421967262693 / 0.0034299441619718607
455 SUMF1_2 3_4419885_G_A / 3_3846683_A_C 0.00013129129316308624 / 0.007888292383663753 0.017506933739797337 / 0.0026519652256760252
456 WDFY4_5 10_48946696_T_C / 10_48774557_A_C / 10_48823427_C_T / 10_48826590_T_A / 10_48709976_C_T 0.00014298234740370438 / 7.877438075749654e-06 / 0.006750199117687904 / 0.008731995024502738 / 0.0057882693531272345 0.03553981554074815 / 0.02592605078891659 / 0.041159506689191376 / 0.03934434383747865 / 0.036092320181802036
457 DSC2_3 18_31091249_T_G / 18_31093490_T_G / 18_31080273_C_T 0.00014328639925920681 / 0.026176748525728964 / 0.004444668756137834 0.002053875263128439 / 3.7895626071773765e-05 / 1.9855794171946574e-05
458 MBD1_4 18_50276088_C_A / 18_50276601_A_G / 18_50275492_T_G / 18_50275430_G_A 0.00014793743904567252 / 0.01877342572270696 / 0.003092273916220477 / 0.0033406482616730533 0.002775832151787685 / 0.0007205116796968372 / 0.027183042271681262 / 0.047488972926164726
459 KIAA1671_2 22_25029373_T_C / 22_25170874_A_C 0.00015698694769979702 / 0.0006020288880688977 0.04147687852552058 / 0.03878706897291035
460 MET_3 7_116740945_T_G / 7_116757685_T_G / 7_116740947_C_G 0.00016797515698396606 / 0.002832945772163542 / 0.002231117554658809 0.00017295700570667475 / 5.0554093231126755e-05 / 0.0012218666498089645
461 RCBTB1_2 13_49585356_T_A / 13_49533768_G_A 0.0001756869709333519 / 0.009455073314037034 0.02533885676009956 / 0.019692263494698818
462 PPL_4 16_4883459_A_G / 16_4894423_G_C / 16_4901058_T_G / 16_4891747_T_G 0.0001758787943382569 / 0.0007098905861696843 / 0.0005647077594982514 / 0.011689794335935037 0.009286392985327631 / 0.04550405331166151 / 0.01682150071796396 / 0.0032410422551606864
463 TMEM63A_3 1_225856800_GC_G / 1_225856891_C_T / 1_225845173_C_T 0.00017631469170194104 / 0.0005047149993335916 / 1.5371108451049484e-05 0.04262290781357216 / 0.031894233309554584 / 0.039853481810337744
464 KDM4B_5 19_5110783_A_G / 19_5047680_G_A / 19_5111856_C_T / 19_5152376_T_C / 19_5114105_T_G 0.00018149502531503815 / 0.0011449297013059851 / 3.0255655048228253e-05 / 0.0056532335440754155 / 0.005029743152006167 0.0038743952075057523 / 0.0010649511420676163 / 0.008640482718151363 / 0.012419815562589162 / 0.0315424322762135
465 TAF4B_2 18_26286027_C_A / 18_26293570_AT_A 0.0001933876544072626 / 0.0006065453361074753 0.005234163638807017 / 0.02416136973363145
466 MAP2K7_3 19_7905750_A_G / 19_7911231_T_C / 19_7910579_A_C 0.00020437876506728577 / 5.172101478935253e-05 / 6.985639899444967e-05 0.026466975715454883 / 0.014436739312155004 / 0.014559538606612087
467 EGFR_5 7_55160480_C_T / 7_55170771_T_G / 7_55205133_G_A / 7_55181370_G_A / 7_55205662_A_C 0.00020841604787297526 / 0.00045465182013688124 / 0.02209047666362801 / 0.00015707737069901731 / 0.0019734565993096485 0.042584839287283 / 0.004588325394927623 / 0.003745674667154008 / 0.030349772078527886 / 0.0007797573368817686
468 MED4_2 13_48079728_CAAA_C / 13_48077399_A_AT 0.00021592440051490123 / 0.00970359638804136 0.028274397927711425 / 0.04285821577494423
469 PSMG1_2 21_39183425_G_C / 21_39175728_T_C 0.00022608775731841645 / 0.012584465994979182 0.00513068025831651 / 0.006708397725563725
470 SYMPK_3 19_45823908_G_A / 19_45835234_G_A / 19_45842628_T_C 0.0002277738548719044 / 7.560389488032653e-05 / 0.007665716537369837 0.03948007686982654 / 0.026714512477614062 / 0.0420060391850977
471 CNKSR1_6 1_26180299_A_G / 1_26181802_G_A / 1_26181989_T_C / 1_26183270_A_C / 1_26184255_A_C / 1_26180691_T_G 0.00022855371657961118 / 0.000553633072814145 / 0.004976293349453925 / 0.0012311577321858017 / 0.00011380023959208459 / 2.366839986118124e-05 0.0031268776228605263 / 0.042309660108738684 / 0.031585176815995236 / 0.007340521806393782 / 0.03620130672603948 / 0.0014019419704167026
472 LGR4_3 11_27373900_C_T / 11_27380156_G_A / 11_27368981_G_A 0.00022889582425503487 / 0.00022889582425503487 / 7.68908468665983e-05 0.02925705779271898 / 0.02925705779271898 / 0.007261247877037425
473 VTCN1_3 1_117157003_C_T / 1_117172345_T_C / 1_117172578_ATTT_A 0.0002510217205927707 / 8.944919469827468e-06 / 0.016016251707355836 0.03055768777478911 / 0.023227355162109414 / 0.001594504991034824
474 CRBN_6 3_3151010_G_T / 3_3152273_A_C / 3_3154589_AT_A / 3_3175444_AT_A / 3_3179746_C_T / 3_3150840_A_ATAAC 0.0002626503373527541 / 0.013274951670738794 / 7.062286693324899e-05 / 0.0004048382754165016 / 0.003012811333138018 / 3.124023410218089e-05 0.0018118056645904023 / 0.00018124433406194467 / 2.1732312542326866e-07 / 7.214198132928058e-05 / 1.1224125713318842e-06 / 3.115850854605648e-06
475 SMCHD1_5 18_2707621_G_A / 18_2724932_A_T / 18_2763699_C_T / 18_2656105_T_G / 18_2795854_A_G 0.00026503656166190905 / 0.009320150621080624 / 0.0042306245640629115 / 0.025865035105419227 / 0.0001080554536414254 7.290016375189198e-05 / 0.03677531412547839 / 0.02250972081801197 / 3.289863234127764e-05 / 0.037011899642268684
476 HDAC11_2 3_13496579_C_G / 3_13496863_T_TG 0.00027757125208069643 / 0.00015267586088891374 0.0271728892750038 / 0.0149184097594151
477 PIK3CD_4 1_9720778_T_G / 1_9721354_C_G / 1_9722498_C_T / 1_9710297_C_T 0.00030314689537509136 / 7.877458405180158e-05 / 2.4181398805762395e-05 / 0.002966501395718009 0.0012148539768169404 / 0.04037203630033394 / 0.011926248274336807 / 0.011351289482054416
478 GCDH_3 19_12891586_G_C / 19_12891749_T_G / 19_12899706_A_G 0.000306793254674835 / 0.0003686903209515677 / 0.009343822168831345 0.0326186066813529 / 0.03376530749875928 / 0.00026130883839357806
479 SEC11C_2 18_59152698_T_C / 18_59158845_T_C 0.00030911539588566946 / 0.00956493460787828 0.0022574597582570113 / 0.029955010760308976
480 SAFB_2 19_5667193_AC_A / 19_5668433_GT_G 0.0003098805881779707 / 0.044739771014985504 0.002063538258127222 / 0.0026106809691974946
481 ATP6V1B2_3 8_20212278_G_C / 8_20218183_C_A / 8_20214681_A_G 0.0003172005709671975 / 1.980177091110716e-06 / 7.277973285376886e-05 0.001539493748390498 / 0.02168738622123026 / 0.025450124159694176
482 PUS3_4 11_125896149_C_A / 11_125896278_A_C / 11_125896309_G_C / 11_125896312_C_T 0.00031902172789162014 / 0.0016768215144890312 / 0.00019026344698916655 / 0.0006367828673033801 0.02249427642441209 / 0.03343255062895107 / 0.0192679955094738 / 0.02546202950317841
483 XDH_2 2_31383804_G_A / 2_31398732_T_C 0.00033628525023115955 / 0.007506095065621764 0.04221528923752448 / 0.006330815240399064
484 WDR7_4 18_56679573_T_G / 18_56781547_G_A / 18_56815915_A_G / 18_57027330_A_ACGGC 0.00034150498667130327 / 3.859660027634848e-06 / 0.002362739963128272 / 0.006245785108127786 1.7583606026050092e-08 / 0.0071713352600959014 / 0.003286339206119661 / 0.04783850584421885
485 GJB2_2 13_20189503_C_T / 13_20189241_T_C 0.00035796332888395017 / 0.008815817126700895 0.005240901157790961 / 0.03930064243744275
486 NFATC1_5 18_79486406_T_G / 18_79486978_G_A / 18_79449015_A_G / 18_79451175_T_C / 18_79467476_A_G 0.0003603073768446487 / 5.049273733042917e-05 / 0.02785434119032008 / 0.02220634088861789 / 0.0002507020345223831 0.018612271205492262 / 0.026732897678207176 / 0.0006549922975230749 / 0.0005874163668026321 / 0.003817175702412812
487 TMEM141_2 9_136791905_T_C / 9_136791680_A_G 0.0004169452454367874 / 3.984588209897019e-05 0.03333885281311693 / 0.020229651998436324
488 GON4L_3 1_155750010_A_G / 1_155813972_C_T / 1_155826993_A_G 0.0004229050700030183 / 0.009903573910672052 / 0.002653632924091959 0.014960076537640884 / 0.0034455240142541605 / 0.03840390796922083
489 THOC1_4 18_218753_C_A / 18_259800_G_GA / 18_264012_G_A / 18_260303_A_C 0.00043864187590166915 / 3.026788938964173e-05 / 6.794818264684467e-06 / 0.0036079810571773866 0.01174777561883113 / 0.04550027828580569 / 0.038030003830584136 / 0.031572528408919984
490 MOCOS_3 18_36268700_A_ATACAT / 18_36195408_G_A / 18_36195416_C_T 0.00045986586717034416 / 0.0014799368107284092 / 0.001731239408871138 3.5975000177046293e-13 / 0.007257645332317387 / 0.011340791435594116
491 TBC1D1_2 4_37920795_A_T / 4_38102880_CA_C 0.000488440493483436 / 0.0003703609091265926 0.005935046245136817 / 0.0040311926239692975
492 MYOF_6 10_93402739_A_T / 10_93335910_A_G / 10_93341723_C_T / 10_93349980_G_A / 10_93456833_C_T / 10_93379679_T_C 0.0005166123667663002 / 0.008644559399569549 / 0.030314897647199957 / 0.007378711399757192 / 0.014254715712501044 / 0.03684609798869681 0.008275987890594253 / 0.013383779511641422 / 1.0154009952651607e-05 / 0.013694532403103154 / 4.5730649026336375e-05 / 0.0006543495060757152
493 RBBP5_4 1_205096605_G_T / 1_205105296_C_T / 1_205121757_C_G / 1_205101436_A_G 0.0005227440198400762 / 0.00526416157273805 / 0.0030657012636972646 / 0.0013099169827028106 0.015139833707904771 / 0.008644227461685475 / 0.012113677398994695 / 0.04046396583686459
494 CLASP2_2 3_33577059_G_GA / 3_33684322_GA_G 0.0005299045117610777 / 0.035952102365944434 0.0005875510468728085 / 0.0001503619637647613
495 PHACTR1_2 6_13206050_C_T / 6_12749854_G_C 0.0005337924756049767 / 0.004317442990912475 0.00039532970764163586 / 0.035334891294853864
496 ANAPC4_3 4_25396670_G_C / 4_25396674_T_G / 4_25405734_A_G 0.0005663311621920986 / 0.0013075373037905336 / 0.0465779350486673 0.000361328058170187 / 0.03220079967613157 / 0.0019550422066677508
497 PSMD5_2 9_120820914_A_G / 9_120824459_T_G 0.0005809565738534683 / 0.0007453253514985393 0.02520354146772891 / 0.030923039758435706
498 ABCC3_4 17_50677651_A_G / 17_50687493_T_G / 17_50677654_A_G / 17_50661130_G_A 0.0006252991041556168 / 0.01577297864138986 / 0.003896335000953405 / 0.0010188260367160796 0.031817085633522264 / 0.0088751921752167 / 0.04421726142800319 / 0.010430910480796323
499 PDS5A_8 4_39826222_A_G / 4_39908552_GA_G / 4_39920322_A_G / 4_39928282_TCA_T / 4_39874433_GT_G / 4_39902522_ATT_A / 4_39922752_TAA_T / 4_39849438_CAA_C 0.0006804734038066716 / 0.0008478404674630213 / 0.0026866381085943365 / 0.00132808107004332 / 0.004772686052629922 / 0.0001500621143076567 / 0.007431666608049384 / 0.000683239660165417 0.013430761436295064 / 0.011566738826207195 / 0.012551712088653194 / 0.04498488242774648 / 0.0069892257136405615 / 0.002775620894064112 / 0.00845393532716467 / 0.015679705858385958
500 ARID1B_3 6_157084627_G_A / 6_157084796_G_A / 6_156779262_G_GCGC 0.0006899056725067633 / 0.00012305812201489173 / 0.003772804433314189 0.002480449952777213 / 0.003319459056638543 / 0.0297382920893214
501 ATP6V1D_2 14_67347484_T_C / 14_67347517_C_T 0.0006971003770886628 / 0.004311412775348075 0.0458931703260112 / 0.04673425843690365
502 TSPAN15_2 10_69506088_T_G / 10_69506076_T_C 0.0007322830521084773 / 0.005306461981362982 0.002401654647845401 / 0.00014212528801531312
503 MLH1_3 3_37007142_A_G / 3_37012077_A_G / 3_37042249_A_G 0.000740971042730754 / 0.00173625605182141 / 0.0001471514352872128 0.0011032555560560838 / 0.0188504234858543 / 0.00278116952700519
504 MCPH1_10 8_6563013_A_G / 8_6414878_G_T / 8_6415022_A_C / 8_6442011_A_G / 8_6444662_G_C / 8_6621439_C_G / 8_6621761_G_T / 8_6643023_C_T / 8_6643230_C_G / 8_6445504_G_A 0.0007930301578494862 / 0.00783515709942311 / 0.0010653421345075958 / 0.01109994940299345 / 0.01748605668447073 / 0.014338437252537204 / 0.004071842491061435 / 0.0006919647053001271 / 0.012376440045340064 / 4.6837103256950894e-05 0.013491192511465546 / 0.00030214631498362885 / 1.4308699249286362e-06 / 0.000801511853950485 / 0.0006599247173344139 / 0.00022140087416861568 / 6.162352636469756e-05 / 4.2830362262517274e-05 / 0.0016916243554951818 / 0.00023822828634849838
505 APLP2_2 11_130110790_G_A / 11_130141602_T_C 0.0008186783504663072 / 0.005144250183511083 0.0021295365540794004 / 0.003817157441436617
506 GDF11_2 12_55743444_T_G / 12_55743453_A_G 0.0008261007388543191 / 0.03983988128537546 0.0038399667498981156 / 0.009308695658692865
507 DHRS1_2 14_24296416_G_A / 14_24296478_G_A 0.0008309168215997886 / 0.0004203355659529219 0.0011625249597744401 / 0.0009759887418146756
508 HMBOX1_2 8_29019076_C_G / 8_29049138_T_G 0.0008669919525569822 / 0.03171806222754735 0.004301459569275475 / 0.002544858829830765
509 FAM129B_3 9_127525147_A_C / 9_127531490_GA_G / 9_127578821_C_G 0.0008771327036108232 / 0.0021288478614580747 / 0.0022519852618096852 0.020053464930431048 / 0.031013612085774283 / 0.0009666899162254512
510 SQRDL_3 15_45676245_C_G / 15_45659211_A_T / 15_45659215_T_A 0.0008907771597097484 / 0.0020094614120517293 / 0.009204846533756823 0.014234174047984662 / 0.023564046281648054 / 0.01334902621156353
511 PAWR_3 12_79621127_A_T / 12_79621127_A_C / 12_79690012_G_C 0.0008953392161992621 / 4.018282599405261e-05 / 0.00946824676498348 0.00916697548400727 / 0.004195646894367022 / 0.04023621560178265
512 ZMYM4_2 1_35386039_A_G / 1_35398970_A_G 0.0009255268514009688 / 0.0010268025209398274 0.047414902378186935 / 0.03220211892803819
513 PNISR_3 6_99400577_G_T / 6_99400380_A_T / 6_99400680_T_C 0.0009649647745143484 / 0.0007159697124499053 / 0.04773876660712681 0.00024058514444646938 / 0.04850971607266792 / 4.045878429706501e-05
514 KCTD1_2 18_26455686_TTTTG_T / 18_26455824_G_A 0.0009651254517760071 / 0.00044897282981570764 0.011878660133524677 / 0.022677959399150814
515 YEATS4_4 12_69360050_G_A / 12_69360067_T_C / 12_69365771_AT_A / 12_69359732_G_C 0.0009657838134951767 / 0.010865427433622845 / 0.00010196861904854136 / 0.004781622790417561 0.00020734016607029562 / 9.576513142549652e-05 / 0.005769237544482665 / 0.00015854860163792644
516 MYH14_4 19_50257459_C_G / 19_50268152_A_C / 19_50223372_A_C / 19_50210705_A_C 0.0009907478792200786 / 0.00031027234534027856 / 0.009603188672713292 / 8.610623849100771e-05 0.003155642857162157 / 0.02679430539669753 / 0.04503905394492344 / 0.01011266806040028
517 TNRC6B_3 22_40246081_G_A / 22_40322746_C_G / 22_40270313_CTT_C 0.0010055560691593062 / 0.007906209412661305 / 0.009164202590452458 0.0005779404176446281 / 0.0047436478866502065 / 0.0364705418337816
518 INTS9_7 8_28780706_C_T / 8_28787754_C_T / 8_28793781_A_C / 8_28793783_A_C / 8_28835266_C_T / 8_28775581_A_C / 8_28775811_A_C 0.0010081741289715016 / 0.004592362992120706 / 0.0005120698884621372 / 0.0002773767656391789 / 0.02714848429874154 / 0.00020236348372473448 / 2.4854306942254155e-05 3.2138156864211546e-07 / 5.188443093736729e-09 / 4.024976616918393e-06 / 2.0930318384840388e-05 / 1.818850464108077e-06 / 3.257318543578891e-07 / 0.018623738854211223
519 SLC9A2_2 2_102708404_T_C / 2_102683152_T_C 0.0010228970665369316 / 0.0005020081620733607 0.009615984790689362 / 0.009480536166577638
520 CABYR_2 18_24159761_T_C / 18_24143046_A_T 0.0010567833091170056 / 0.0014968601112293539 0.005047158957377522 / 0.04396847891686953
521 GTF3A_3 13_27435783_G_C / 13_27434894_G_C / 13_27424632_T_C 0.0011190222584791265 / 0.004681955550098893 / 0.007918207229892667 6.8305505569380366e-06 / 4.651074413645253e-05 / 0.009084963551764854
522 C17orf80_2 17_73243051_A_T / 17_73243095_T_G 0.0011654886198261731 / 0.004494422448579687 0.010085515976883222 / 0.004743723689710052
523 SMU1_3 9_33042147_G_GC / 9_33048282_A_C / 9_33062151_T_C 0.0011669696398791268 / 7.696816352170192e-06 / 0.01499894245869885 0.04706645923394905 / 0.031220105263435657 / 0.0036210535474734524
524 APP_3 21_25881669_T_G / 21_25982373_C_A / 21_26053118_T_G 0.0011674640267523098 / 9.245713138747127e-05 / 0.004308340981093568 0.0009005203285702301 / 0.013334900192842466 / 0.04036723851049838
525 SF3A2_2 19_2247907_A_C / 19_2248684_C_T 0.0012266864812599976 / 0.002990131415570729 0.0030981828107111728 / 0.0468855780292127
526 MCM3AP_14 21_46242985_CA_C / 21_46245202_GAAGA_G / 21_46254361_G_A / 21_46256797_G_A / 21_46257020_T_C / 21_46258860_A_G / 21_46261213_T_C / 21_46265873_T_C / 21_46266025_A_G / 21_46266238_C_T / 21_46266260_T_C / 21_46272884_C_T / 21_46275481_C_G / 21_46285323_T_C 0.0012527393891514607 / 0.00036535930217642055 / 0.0024609384326425487 / 0.04643229751040803 / 2.118510728826028e-05 / 2.887414182548247e-06 / 1.05276826358399e-07 / 0.00025970635193207507 / 0.0005620952054741439 / 5.716570824504117e-07 / 2.4174995461629513e-07 / 0.005818667124032619 / 0.0467983305638919 / 8.653902898907501e-05 0.0002736694696369044 / 1.7616074069549246e-05 / 1.3003369428929314e-06 / 2.3123117180340123e-05 / 2.0562643179742515e-06 / 8.354163607590267e-05 / 0.00029806921327546384 / 5.3648509797744586e-06 / 1.5227506753175702e-05 / 7.251148442399709e-05 / 0.00010743801329645878 / 1.1615547532865214e-07 / 1.858126949270524e-05 / 3.8129306546053804e-06
527 CLIP4_2 2_29160508_G_A / 2_29167435_A_G 0.001256177781998004 / 0.0032393618837062445 0.004054702946614456 / 0.02363327883448803
528 TSC22D1_3 13_44574373_G_T / 13_44574380_T_G / 13_44573675_A_G 0.001377124084836583 / 0.015722049040498624 / 0.02470162730235456 0.0064804726533923464 / 0.0020304861527569297 / 5.907708401459935e-06
529 PKP3_3 11_403980_G_A / 11_404317_C_T / 11_397331_G_C 0.0013876622699982295 / 0.016481995505848203 / 3.1228708373215485e-07 0.018674886861837936 / 0.009799627021991927 / 0.04880244320980319
530 CASP8AP2_4 6_89867828_C_A / 6_89846678_CT_C / 6_89854793_T_G / 6_89867387_T_G 0.0013957399418989352 / 0.0012351347166879073 / 0.01485793169450881 / 0.029929799896047743 0.004638447540709211 / 0.00012650141154496166 / 0.0049509957510286366 / 0.007919221858804896
531 SUGP1_3 19_19297181_T_G / 19_19320614_T_G / 19_19321154_G_T 0.001497727430536191 / 0.0019392453885837852 / 1.1604792778575085e-06 0.004713359874536658 / 0.0005015062282813169 / 2.8690586178505662e-05
532 MTMR14_2 3_9701714_TGGAG_T / 3_9688859_C_T 0.0015228522402605245 / 0.0034777774244127892 0.0064175485415249155 / 0.007328897092709648
533 RIOK2_2 5_97167674_T_C / 5_97179013_C_G 0.0015264299232640686 / 0.0009434563320843556 0.018107759921786072 / 0.01839083931192911
534 HCLS1_5 3_121631746_C_A / 3_121642799_G_A / 3_121642940_G_A / 3_121647276_C_T / 3_121647530_A_G 0.001531370286315401 / 0.007140010061027548 / 0.0056491920403494 / 0.0056491920403494 / 0.0033035345652737084 0.008666157872154578 / 0.028236059065420614 / 0.02925717871219745 / 0.02925717871219745 / 0.035251625940568736
535 USP20_2 9_129868385_TGAC_T / 9_129868775_T_C 0.001542609843192008 / 0.006644626432996628 0.028200134219961023 / 0.0362382211673806
536 OGT_3 X_71555839_AT_A / X_71555852_A_G / X_71556880_G_A 0.0015512975406232336 / 0.0006090442157279421 / 3.794330620993244e-05 0.03251106613283236 / 0.03051485289420325 / 0.02757062507023744
537 ILF3_4 19_10677068_C_G / 19_10683073_A_G / 19_10683954_G_T / 19_10689074_T_C 0.0015595887966999382 / 0.0008443307208163777 / 0.0014177004651836508 / 0.006992884477782401 0.02905299869911714 / 0.023662506952371584 / 0.024462171404793464 / 0.04401306590016355
538 AKAP17A_6 X_1593528_G_T / X_1593824_T_C / X_1593829_A_C / X_1593416_T_G / X_1599467_G_A / X_1601004_C_G 0.0016145426205006856 / 0.006626142886833432 / 0.0006549722036186197 / 1.3622821646377586e-09 / 1.4367220837077828e-05 / 0.0013113963664485734 1.7500984806304813e-06 / 0.004424305821371996 / 0.031339887946813465 / 0.0002164120997390045 / 0.0019808227552202268 / 0.022975239267281157
539 HLA-DPB1_25 6_33084838_T_C / 6_33086094_A_G / 6_33086100_G_A / 6_33086430_A_G / 6_33086431_C_T / 6_33086458_T_G / 6_33086503_T_C / 6_33086504_G_A / 6_33086525_T_C / 6_33084940_A_C / 6_33084942_G_A / 6_33084946_C_G / 6_33084959_G_A / 6_33086548_G_C / 6_33086623_T_C / 6_33086627_A_G / 6_33086636_T_G / 6_33086637_T_A / 6_33084934_T_C / 6_33086390_G_A / 6_33086399_T_A / 6_33086400_T_C / 6_33086554_T_C / 6_33086565_T_A / 6_33084918_T_G 0.0016170360777901915 / 0.035517335536449965 / 0.03859616732889496 / 0.0050484605719981115 / 0.006920322099559346 / 0.04723136941351201 / 0.01042058063158112 / 0.01982161136592692 / 0.004676661817713314 / 9.909297446240884e-05 / 0.00013864663028350917 / 0.0002553757712440544 / 0.00010148054048444211 / 0.0005733999890735651 / 0.001447191231242919 / 0.0006504207970493822 / 0.0014159972834331574 / 0.0011151099996242373 / 1.670066308093462e-07 / 0.002181120675090949 / 0.001551134422399547 / 0.001551134422399547 / 0.00018558558739674276 / 0.00027961484945332547 / 0.04098305035004495 0.01738899621763897 / 0.0071970972262367875 / 0.0015085198751619124 / 0.009855204235078744 / 0.009159540445250336 / 0.0034148006003537623 / 0.0007725393378843376 / 0.00046914802311591013 / 0.0002211234236168895 / 0.01812705600921171 / 0.02551712776803155 / 0.02768815887474311 / 0.01961732896362046 / 0.00424548612011435 / 0.03272474670019398 / 0.034386513937956574 / 0.03829938821939845 / 0.02718298788851184 / 0.0008766728067700178 / 0.0010412174325617669 / 0.00027430911944352433 / 0.00027430911944352433 / 0.007068880728833383 / 0.0015589855961860727 / 0.0023729962607638784
540 ERBB2_7 17_39723335_A_G / 17_39725167_A_G / 17_39727303_T_G / 17_39723531_A_C / 17_39728154_A_C / 17_39709434_A_C / 17_39728753_A_G 0.0016350878443782172 / 4.136237081824547e-05 / 0.046602377151608726 / 0.0033861558195955052 / 0.0037588249676302338 / 0.03412502593916668 / 0.0037443415073794024 0.030443197190865717 / 0.016249088634527818 / 0.0009745478853255011 / 0.014043142620610086 / 0.002489169967351341 / 0.005151661954164628 / 0.0238332618696792
541 CNOT10_5 3_32773739_A_T / 3_32705030_A_G / 3_32717271_G_A / 3_32727933_TAA_T / 3_32704796_GT_G 0.0016526003311275095 / 0.0001231320148601887 / 0.00017728596732259782 / 0.009536795008099045 / 0.003991838672618705 0.0019461949221222566 / 0.0007110070373588129 / 0.0032142136890770555 / 0.009535253937430231 / 0.00725632017358903
542 BTAF1_3 10_91959744_A_G / 10_91959746_A_G / 10_92024732_G_GTTTTTTTGTT 0.0016639394777511788 / 0.017417232932444852 / 0.002725136934144748 0.0011854132574195902 / 0.002486161819230707 / 0.02294891315626264
543 KDM2B_2 12_121579961_G_A / 12_121444386_T_G 0.0016808767205032673 / 0.0018129427277068664 0.04715734536774355 / 0.019501973878425127
544 OSBPL8_3 12_76371622_A_G / 12_76459031_C_T / 12_76389816_G_A 0.001685976661542144 / 0.0019376612844524102 / 0.00034069060776455845 0.010145024239484482 / 0.023570151478943115 / 0.01081801975958232
545 SPATS2L_4 2_200477598_G_T / 2_200412421_T_G / 2_200477943_T_G / 2_200473083_GAA_G 0.0017077762924250339 / 0.005542406637614594 / 0.008957206491580714 / 0.02371288438579117 0.021972245787165747 / 0.03547678698863923 / 0.016080388811817628 / 0.0009052273948575811
546 KMT2C_2 7_152273692_G_A / 7_152177504_T_G 0.0017215770748878 / 0.0257040166730586 0.02044755694417402 / 0.0007976241891358237
547 C3_8 19_6679370_G_T / 19_6679500_C_T / 19_6679552_T_C / 19_6693625_A_G / 19_6710771_G_T / 19_6713164_G_C / 19_6713251_G_A / 19_6718376_G_C 0.0017242987096359706 / 0.011130009901872313 / 0.01112305118572054 / 0.03308700773309592 / 0.0007547726119911367 / 2.8401856724118085e-05 / 9.337374703033051e-05 / 0.00015757450123976866 0.021139612203482698 / 0.001328408206242609 / 0.0024788445051524576 / 0.009567716450671235 / 0.00949274728217466 / 0.015144191214707904 / 0.01135067374028043 / 0.013151961372936128
548 NFX1_3 9_33290534_A_G / 9_33290690_G_C / 9_33344254_T_A 0.0017340354418381332 / 0.00213071003554307 / 0.0008944872419168263 0.004533123491706767 / 0.03459515757598255 / 0.005356381351212509
549 KATNAL2_4 18_46963135_T_TGC / 18_46969062_T_TGC / 18_47028569_T_TGC / 18_47069438_A_T 0.0017826363249020844 / 0.0002158210829164119 / 0.002959998960433205 / 1.0166082620431142e-06 0.023566439092900897 / 0.042581318341999685 / 0.01792891562738572 / 0.04594422713064072
550 PLRG1_8 4_154538042_A_T / 4_154539961_T_C / 4_154540535_A_C / 4_154540996_A_T / 4_154544383_A_G / 4_154545783_T_C / 4_154546035_A_G / 4_154548807_G_GA 0.0017837327552204187 / 0.0022747756662197635 / 0.013232282684609756 / 0.006089524083842604 / 0.023466965037692716 / 0.011286717487280188 / 0.015766497021373137 / 0.001132424851953552 0.0025156591482322463 / 0.003876861205834139 / 0.008064183834782563 / 0.004736898325652559 / 0.004629934695328492 / 0.00625636632504058 / 0.006403275082048386 / 0.0051675452547446255
551 EDN1_2 6_12295840_T_G / 6_12295843_T_G 0.00181409210724337 / 0.0002763328454078789 0.024241257142762068 / 0.012273310260196891
552 RABEP1_2 17_5381248_TAA_T / 17_5361621_C_T 0.0018150712755665734 / 0.004152920156402154 0.007056745600928623 / 0.01880219353285387
553 RUNX3_2 1_24907301_T_G / 1_24907326_T_G 0.001835528705698884 / 0.0008816631461578386 0.0479402881785652 / 0.03367486268556343
554 ARID3A_2 19_929678_G_A / 19_965056_A_C 0.001844502898018781 / 0.0038221459346221604 0.0024448512910076343 / 0.038475803182823655
555 SETD2_6 3_47037622_G_A / 3_47083895_G_A / 3_47084411_A_C / 3_47084426_CT_C / 3_47101417_TCC_T / 3_47121171_A_G 0.0018886443163515503 / 0.0005724676673950148 / 0.0018507014329319895 / 0.002298087295161151 / 0.0018577181187481573 / 0.000573845912909288 0.000977617083994294 / 0.008205866594339892 / 0.008011204119723829 / 0.009083566444260623 / 0.0015764712914139378 / 0.0002475067417184235
556 MYO1E_4 15_59272288_G_C / 15_59223315_G_A / 15_59178167_C_T / 15_59138181_A_C 0.0019255092745879315 / 0.027929898310990055 / 0.00031389151980896725 / 0.04411515555617615 0.006181875879725325 / 0.0073567891788311425 / 0.014590984354000915 / 0.000506485287819266
557 SUGP2_5 19_19024510_A_G / 19_19025732_C_T / 19_18994964_G_A / 19_19026233_T_A / 19_19010089_T_G 0.001983285518752092 / 0.002941993796204625 / 0.01284029709782453 / 0.0020741831309949127 / 0.0008037924072482433 0.040831519054544435 / 0.008182273259557721 / 0.005749298256034085 / 0.007605074821863024 / 0.027745888328438603
558 KLHL18_3 3_47319581_T_G / 3_47344095_C_A / 3_47322481_G_T 0.0021891626387678365 / 0.0006911454072889093 / 0.0001458644297550943 0.013218876001835087 / 0.0063137500959640856 / 0.018113274866617776
559 TYSND1_2 10_70138599_C_T / 10_70140172_G_A 0.002210990629147794 / 0.0039640911222843436 0.009659099597965872 / 0.027700702531791875
560 EIF1B_5 3_40309993_C_T / 3_40311393_C_T / 3_40311934_CAG_C / 3_40311768_T_G / 3_40309649_C_G 0.0022271726409335488 / 7.503385234156634e-05 / 3.177548305907501e-05 / 2.1365604310883664e-06 / 0.006831469965345718 0.005496962588873379 / 0.0028348307389023737 / 0.0036905138907599726 / 3.949648255514959e-06 / 0.04857611284248277
561 C14orf79_2 14_104991443_T_G / 14_104992803_A_C 0.0022393155386724074 / 0.009479451263550959 1.7720854995940125e-07 / 7.586102006604381e-07
562 SLC52A3_2 20_761203_A_G / 20_763790_T_G 0.002271842149158581 / 0.0019785326127115858 0.0003747217630289052 / 0.003089764091274667
563 HDAC5_2 17_44087216_A_G / 17_44077102_A_G 0.0022775299741103626 / 0.009100177186215046 0.03161998848113075 / 0.021561030479614426
564 TCF7L2_4 10_112951117_C_T / 10_113165703_A_C / 10_113165557_GA_G / 10_113141157_T_G 0.0023062734857754803 / 0.006196689121801137 / 0.00015949311848004983 / 0.01042058063158112 0.01060529288873283 / 0.008309178089758909 / 0.04233413143117931 / 0.004504822920252362
565 DSP_2 6_7577915_A_C / 6_7581379_A_G 0.002345981327408041 / 0.02625851263459552 0.0018316675069518392 / 0.005935959963292785
566 GAS7_3 17_9943314_G_A / 17_9943407_C_A / 17_9940079_A_C 0.0024862474118096554 / 0.02161659825841676 / 0.01209844734945125 0.014304203615809547 / 0.007643530014898026 / 0.02182596122662912
567 ARHGEF5_5 7_144365079_A_C / 7_144371121_T_C / 7_144371117_T_G / 7_144364997_T_C / 7_144365475_T_C 0.0024945926126355923 / 0.02354548207827752 / 0.006211748094610735 / 0.002934715516170928 / 1.727507617843059e-06 0.02343547139067424 / 0.007520412833757487 / 3.130275501973943e-06 / 0.02778730920062768 / 0.003065464879158348
568 PTPRU_3 1_29275579_A_C / 1_29310715_T_G / 1_29255395_A_C 0.002539773248455689 / 0.0077226993558171956 / 0.0009778041944005973 0.007805553893565897 / 0.021084479691732515 / 0.046498222792818684
569 TTC39A_2 1_51288088_T_G / 1_51295930_G_T 0.002570863553329518 / 3.4909921895622464e-05 0.0009000808652072745 / 0.009859747746545187
570 KRT15_3 17_41516910_C_A / 17_41518370_T_G / 17_41518744_A_C 0.002573274763251264 / 0.011567941016623695 / 0.003420135618507444 0.005435309336568784 / 0.004600527769071169 / 0.020891294013713143
571 UBXN8_5 8_30744093_TC_T / 8_30744288_C_T / 8_30751256_A_G / 8_30751544_T_G / 8_30751561_A_T 0.002591192476579632 / 0.0006909486125387932 / 0.02443874890142141 / 0.03582659928743899 / 0.03582659928743899 1.0603773748192244e-05 / 4.865545060608271e-05 / 6.152112049146202e-05 / 3.811929186552625e-05 / 3.811929186552625e-05
572 SMARCA4_3 19_11003321_G_T / 19_11010261_C_T / 19_11026459_T_C 0.002630441388397466 / 0.010463060303081006 / 0.010088756192701873 0.010970724428159849 / 0.007818649393052565 / 0.008366105586796981
573 PSMD6_2 3_64018733_C_CA / 3_64023832_T_C 0.0026976125076584256 / 0.009878175034845338 0.010870617478385693 / 0.0044822108745555264
574 CCDC18_7 1_93226524_AAT_A / 1_93232665_C_G / 1_93180876_T_C / 1_93221838_T_C / 1_93239253_G_A / 1_93226314_TG_T / 1_93180563_T_G 0.0027123682464393244 / 0.0016657739488188466 / 0.0033797977817805816 / 0.0015978624867728733 / 0.002134999320804664 / 0.013590020119742256 / 0.003793743444563949 0.04835531632243841 / 0.0045740699346053185 / 0.00032147121850177287 / 0.0017542576026547778 / 0.0017542576026547778 / 0.003812032810040999 / 0.0440564257256616
575 MKRN2_2 3_12572367_T_C / 3_12576770_C_T 0.0027864675750747985 / 7.698740851570175e-06 0.0004133954800997532 / 0.00023875055451781275
576 POU2F2_2 19_42122415_A_C / 19_42116791_T_G 0.002831354927429977 / 0.00132487414614545 0.0009318465407261826 / 0.03195305321524156
577 CSNK1G2_2 19_1941300_C_CG / 19_1978367_A_C 0.002838297409364801 / 0.002057750736247525 0.0019266812436141687 / 0.04165592627236607
578 NADK_4 1_1754601_G_T / 1_1755504_T_C / 1_1755523_C_T / 1_1757030_C_G 0.0029196774804306136 / 0.0022487075080235863 / 0.0010425578675322944 / 0.004582127513664698 0.031872533533518106 / 0.005752610352558396 / 0.0031781335571060463 / 0.03556781287056178
579 CD151_2 11_837662_TG_T / 11_835877_C_T 0.003028852216804449 / 0.04104019245722205 3.3851264417503082e-06 / 0.005759250847020773
580 ATP5A1_9 18_46098069_T_C / 18_46086016_C_T / 18_46086895_T_C / 18_46086986_C_A / 18_46087562_T_C / 18_46088355_G_T / 18_46090014_T_C / 18_46098295_T_G / 18_46090084_G_T 0.0030434677700528394 / 0.0004952827031339936 / 0.007810554102540824 / 0.000648733348082285 / 0.013897849420604671 / 0.002385765549363269 / 0.0010062790676919331 / 0.005315177457540565 / 0.01959258956571804 0.0003047097440701736 / 0.0142075393191002 / 0.036323160579493724 / 0.013872652612254888 / 0.0036567482317310593 / 0.02085147005163321 / 0.01507674177782532 / 0.03454712220311499 / 0.007087269321528623
581 ACTR8_2 3_53876892_G_GT / 3_53876872_GA_G 0.003050264516832101 / 0.008934315374097621 5.979539416096826e-07 / 0.005988354207232076
582 KDM4C_3 9_7105548_G_C / 9_7170165_G_A / 9_7174813_T_A 0.003056285777006115 / 3.848309807154845e-06 / 0.028252899669062883 0.04853749604959928 / 0.04549941716484139 / 0.006907446061910031
583 AZI2_2 3_28331971_C_CA / 3_28340396_A_T 0.0031048857689516462 / 0.003592307504254993 0.014552320913166257 / 0.004305743220750069
584 SERTAD4_2 1_210241533_TC_T / 1_210241536_T_C 0.003132119859215549 / 0.009639231593611885 0.019963608830813308 / 0.006491338228956634
585 USP15_4 12_62302696_T_G / 12_62383784_G_T / 12_62404146_G_T / 12_62335441_G_C 0.0031338510061822643 / 0.014094139089898441 / 0.0031672583932668176 / 0.002293994252085232 0.00033081922207003954 / 0.0033557619531166464 / 0.00033479875073063453 / 0.039619833047337696
586 DOCK1_3 10_127012556_G_A / 10_127444251_G_A / 10_127248024_G_T 0.0031585127425178675 / 0.027688640963832358 / 0.0004879172723173928 0.004938898221400919 / 0.007801850145866487 / 0.020184142497530616
587 ITGB4_4 17_75736347_G_A / 17_75739839_G_A / 17_75742534_T_C / 17_75754823_A_C 0.003162157220078509 / 0.008328692436238487 / 0.007894779942929558 / 0.009860822677928005 0.01217344559335353 / 0.002457354260511787 / 0.01159864028497844 / 0.005496381411893582
588 ZDHHC17_2 12_76843188_G_A / 12_76815330_A_G 0.0032793703796479517 / 0.0004434027342669209 0.011228793208829205 / 0.0047926477879100746
589 STEAP4_2 7_88282586_G_A / 7_88283906_C_T 0.003287923696320924 / 0.0091566014690908 0.020956268813510096 / 0.020511289316670928
590 SON_2 21_33553093_A_C / 21_33553095_T_C 0.003287986051022628 / 0.0002182856164179604 0.023262781799198717 / 0.04085529307129965
591 SUZ12_2 17_31937449_T_G / 17_31937443_C_G 0.0032919118028606463 / 5.6901277653871055e-05 0.001414433092115542 / 0.02301260051890533
592 ZNF708_5 19_21294577_C_T / 19_21309149_T_A / 19_21309260_G_A / 19_21294601_T_G / 19_21310453_A_T 0.003305225750188495 / 0.0035049021956979373 / 0.004520698246333428 / 0.0002495831365867789 / 0.0067675270617948155 0.007544201865148675 / 0.008126720123629898 / 4.891895383413758e-05 / 0.0371668734968966 / 0.010566885319869566
593 NPAT_3 11_108173261_C_T / 11_108188273_T_C / 11_108222481_A_T 0.003344965508099712 / 0.00917775939993597 / 0.039703241026176714 0.002496786878352684 / 0.04574657942913745 / 0.0037813176541691743
594 HSPG2_4 1_21848107_A_G / 1_21857246_A_G / 1_21854055_T_C / 1_21885485_A_C 0.003347609104205378 / 0.0006068526113653472 / 0.003704007084337551 / 0.00357256954025205 0.02697977272492986 / 0.03734459078034153 / 0.0018455746031783011 / 0.028105372966297285
595 TOP2B_6 3_25618603_G_GT / 3_25620066_T_TA / 3_25630287_C_T / 3_25632344_A_C / 3_25632600_C_A / 3_25638247_T_C 0.0033763968792717173 / 0.008450908635462133 / 0.0012336549489001688 / 0.00024044846753362568 / 0.0010363758807633305 / 0.0007533307901546944 0.009406841430847504 / 0.006029442482514222 / 0.011303133266640238 / 0.01883862996744124 / 0.018119501937010576 / 0.00877690000990295
596 MUC16_3 19_8894929_A_T / 19_8979498_T_G / 19_8957088_C_T 0.0034029575974152395 / 0.00041258558252529193 / 0.001514661605616884 0.03041637790901308 / 0.002432253712629655 / 0.03213344574711092
597 TMEM144_3 4_158244471_A_C / 4_158253356_T_G / 4_158253361_T_G 0.0034876691228988683 / 0.0005647077594982514 / 0.0008326481477321537 8.607739077270522e-05 / 6.799118981257274e-05 / 0.0018072956471693355
598 SDC1_2 2_20204203_T_G / 2_20202279_A_C 0.003538404752618725 / 0.0156379764488537 0.012274967718012342 / 0.005607450656810002
599 RBM6_7 3_50054242_G_T / 3_50054246_C_T / 3_50054250_C_T / 3_50054257_G_T / 3_50054263_T_G / 3_50075177_T_G / 3_50066484_G_A 0.0035570559373772188 / 0.00580221866025999 / 6.528791603289091e-07 / 0.001554315699435568 / 0.0007276852324929738 / 0.008508212434548797 / 0.002518709860742996 0.0124136469122058 / 0.0004024483543288937 / 3.272618868931358e-05 / 5.8729619078742086e-05 / 0.00033057063887385755 / 0.000930075295183941 / 0.014325869585835831
600 FIP1L1_2 4_53377738_T_C / 4_53414538_G_GA 0.003618394551763958 / 0.000808630514933739 0.020612870650917825 / 0.014620279830838013
601 BAZ1A_6 14_34773800_G_A / 14_34761774_C_T / 14_34761902_A_T / 14_34771458_C_G / 14_34780118_A_G / 14_34862082_G_A 0.003674207621815091 / 0.00048794862757524084 / 0.0004529362621637724 / 0.00048794862757524084 / 0.0004529362621637724 / 0.0008633899521319537 0.020819109086183382 / 0.029434275834813995 / 0.038030144241646684 / 0.029434275834813995 / 0.038030144241646684 / 0.029434275834813995
602 ABLIM1_2 10_114468289_G_T / 10_114613516_C_T 0.003679575880821695 / 2.068694569003633e-05 0.013324532381057309 / 0.007365229118612223
603 KCTD11_3 17_7356629_G_T / 17_7356036_T_C / 17_7353417_T_G 0.003754571069046404 / 0.00017366868689943718 / 0.0012390848435611386 0.04600482755406116 / 0.034157938547959045 / 0.0012683162409826913
604 MICALL2_5 7_1442358_T_G / 7_1448634_T_G / 7_1438692_G_A / 7_1438940_G_A / 7_1434765_T_C 0.0037969325863282813 / 0.03384278289950645 / 0.029060946696468106 / 0.029060946696468106 / 0.0032003913710269877 0.003849439864891702 / 0.00957207447144348 / 0.001706040259270731 / 0.001706040259270731 / 0.009156797658911076
605 RFC1_4 4_39304977_A_C / 4_39317086_A_G / 4_39327482_G_A / 4_39366034_T_C 0.003804607068014229 / 0.002653298567768597 / 3.2670263647126826e-05 / 0.042208647376131 0.0020300192179148733 / 0.00027426635734190813 / 0.008638827908989666 / 0.0022061266378501725
606 AP1M2_5 19_10572926_C_T / 19_10579645_C_T / 19_10587097_A_G / 19_10587125_G_T / 19_10579014_TC_T 0.0038087692058226532 / 8.991675208563765e-05 / 1.1792724900645332e-05 / 5.261102684897293e-05 / 0.001877531631940374 0.02140839327697613 / 0.010527568877864577 / 0.0015316982164778213 / 0.023908631854345174 / 0.00821632833656041
607 RPS23_2 5_82278173_C_T / 5_82278363_C_T 0.003957786808705407 / 0.0008315075457503006 7.911328672036997e-05 / 2.402875788954321e-05
608 BARX2_2 11_129436792_A_C / 11_129436677_C_T 0.004015743982394933 / 3.8908364285059496e-05 0.0011297752143511178 / 0.006988734279853065
609 LRRC1_3 6_53913863_T_G / 6_53920478_C_A / 6_53899709_T_G 0.004131339558552957 / 0.0030469251357492584 / 1.3663885062737747e-07 0.02863343366704425 / 0.016849492489466617 / 0.0009777953947081833
610 POGZ_3 1_151423306_T_C / 1_151407350_A_C / 1_151459156_T_C 0.0041738932600083895 / 8.993795886819927e-07 / 0.008612349643764727 0.020015181832936737 / 0.02909488569964382 / 0.009809035888391762
611 PRKCI_2 3_170275187_CTTT_C / 3_170263168_CAAAAA_C 0.00425052374891476 / 0.002760121279997125 0.00012798467543814748 / 0.021989752739530143
612 PGBD1_2 6_28296652_T_G / 6_28298177_A_T 0.004288328285551539 / 0.00932669296817631 0.005702673764439882 / 0.020264770709017343
613 LGALS8_3 1_236537373_GAGC_G / 1_236539197_AGTTT_A / 1_236551447_T_C 0.00435552243438307 / 0.02490692830672263 / 0.005408439057885871 0.0007287918934518675 / 0.002689054589007359 / 0.013132223069499007
614 CYP4F11_7 19_15913852_G_C / 19_15914366_C_T / 19_15924707_G_A / 19_15927524_G_A / 19_15927580_G_T / 19_15929482_A_G / 19_15929663_T_C 0.004494422448579687 / 0.004118655653677505 / 0.009014030424870815 / 0.007737694175519336 / 0.005296914283554929 / 0.006573618747648885 / 0.0045029584577228 0.01037304937937457 / 0.022954596803030098 / 0.0124267741256932 / 0.011141708950444295 / 0.011312909542474079 / 0.016341169913201302 / 0.013422572430360932
615 ZNF24_3 18_35337816_G_GA / 18_35337680_T_C / 18_35344446_G_A 0.004517003572403403 / 0.00020451573869716152 / 0.02552298264953765 0.012709161524744772 / 0.04404021168973007 / 0.008269738810110396
616 ANKS6_2 9_98796162_G_A / 9_98778486_A_C 0.0045700537784898465 / 0.009257993261520582 0.047044500480316616 / 0.03370066145919663
617 POLR2B_6 4_56995192_C_T / 4_57010789_G_A / 4_57015549_G_A / 4_57025073_G_A / 4_57005234_AT_A / 4_57023798_AT_A 0.004738473697291275 / 0.00020500907676743697 / 0.0003428363180097953 / 0.00033030198738810576 / 0.000896266309671023 / 0.010078450270635015 0.00041802227600176717 / 0.03709404459710368 / 0.03851787302536296 / 0.03254648423802934 / 0.03704331970217288 / 0.007472844031288456
618 CDC42BPB_3 14_102939620_T_G / 14_102952453_T_G / 14_102945931_T_C 0.0049774861882444345 / 0.0002680622756333545 / 0.004938189506165365 4.775637628078603e-05 / 0.003315245095495249 / 0.001918499391114136
619 WDR62_3 19_36058788_C_T / 19_36084743_G_A / 19_36094002_C_T 0.005088637492213912 / 0.016915078735087723 / 0.007443859285838674 0.0005331846126391098 / 0.000415677937125236 / 0.0005211199976091131
620 PLCB2_2 15_40298884_T_G / 15_40297623_G_A 0.005308041472208479 / 0.0013941969299030182 0.025458039339188058 / 0.04960868971387879
621 ZEB1_4 10_31461157_A_C / 10_31521191_A_C / 10_31521414_A_T / 10_31461247_AT_A 0.005342806393282525 / 0.01137703502325166 / 0.0014780611664163069 / 5.800757504246017e-05 0.013618649263675358 / 0.006377825075174489 / 0.011119739548999731 / 0.0019400920584000448
622 NDUFAF4_2 6_96891399_CA_C / 6_96896910_G_A 0.005489763925784804 / 0.0005269475943804068 0.01909002509011261 / 0.009369364198285348
623 PHIP_9 6_78947674_G_A / 6_78954723_T_C / 6_78955031_T_C / 6_78955493_T_A / 6_78969860_A_G / 6_78985312_C_T / 6_78998206_C_T / 6_79043075_T_C / 6_78947709_T_C 0.005530164992886238 / 0.00548954353554207 / 0.01455660590235654 / 1.6913729880297845e-05 / 0.0035647193470514853 / 0.005289398736036421 / 0.001837097400913216 / 0.004209432623363282 / 0.02442132743404569 0.0010048550446085317 / 0.00648756713202656 / 0.0009432749408838033 / 0.009594339103514994 / 0.0017203137452171692 / 0.0007527047164367361 / 0.006763071535609179 / 0.0016364259457283912 / 0.0006553233953188175
624 C6orf203_2 6_107044172_C_T / 6_107051038_GTTTTC_G 0.005594780806642859 / 0.010350958813062314 1.8543097341742985e-05 / 4.7416804336943046e-05
625 RIOK1_2 6_7390137_G_T / 6_7410502_GT_G 0.0056620989198510035 / 0.009940460227242327 0.004558417307934729 / 0.0007644747214841657
626 STX2_3 12_130796169_T_C / 12_130821769_C_G / 12_130827084_G_A 0.0057763908603848755 / 0.0026232291323331123 / 0.0017127068028307182 0.03019238327054641 / 0.01065610617547119 / 0.004236660791662807
627 DOCK9_6 13_98797273_A_G / 13_98888796_T_A / 13_98848509_C_T / 13_98902701_G_A / 13_98883901_TA_T / 13_98977850_C_T 0.005927598026328671 / 1.199291147137571e-06 / 0.00025790841294325934 / 0.0030628908663900517 / 0.003688722979152048 / 1.1373148571396284e-05 0.006004783016582045 / 0.01781055671478815 / 0.005840989451706359 / 0.025244747630348088 / 0.020609371467392473 / 0.01526774575825921
628 ADAM15_4 1_155056046_G_A / 1_155058081_A_C / 1_155058900_C_T / 1_155053372_T_G 0.005983172351155387 / 0.003608774130493322 / 0.02011005006826893 / 0.013070176515727179 0.02587883400458268 / 0.038829781369162535 / 0.006114928575864872 / 0.005438593481843924
629 ZNF430_3 19_21020746_C_T / 19_21033730_G_A / 19_21022725_C_T 0.006039060973644978 / 0.0017404412233575466 / 0.0032443389741318627 0.0014493947676260713 / 3.875366882434858e-05 / 7.931044376997757e-06
630 SLC41A2_2 12_104866497_A_G / 12_104805360_A_C 0.006042414055759166 / 0.003878181222682689 0.04584324420776458 / 0.01814258498012539
631 ARHGAP5_2 14_32092970_T_C / 14_32154828_T_C 0.006122997092230283 / 0.00899034241039037 0.000109609141495362 / 0.0028505632724505807
632 CTSB_5 8_11848168_C_G / 8_11853379_G_C / 8_11847933_G_T / 8_11852665_T_C / 8_11848361_G_A 0.006170091093918575 / 0.013883502523880249 / 0.013105854756963943 / 9.23481096080534e-05 / 0.0030280965583678638 0.010885538500044391 / 0.006363373856765906 / 0.00949712914495799 / 0.00465817682934427 / 0.02101769256107376
633 INTS10_7 8_19824136_G_A / 8_19825034_A_G / 8_19825081_A_G / 8_19832122_T_C / 8_19823225_T_C / 8_19823468_C_T / 8_19820404_G_A 0.006249656348718163 / 9.755626466214517e-05 / 0.0032595992956769558 / 1.3994534854585697e-05 / 0.01825573585413804 / 0.0007017951945376175 / 0.0019656324021710553 0.004251571736144285 / 0.006724158153343274 / 0.02600076241538477 / 0.015595096037435119 / 0.0063513471360198154 / 0.004329630966639476 / 0.012844960200188478
634 CHAF1A_3 19_4406163_G_A / 19_4442339_C_T / 19_4422720_A_G 0.0064074940660708 / 3.653207387854824e-06 / 1.4819698101788669e-05 0.0008752119921859383 / 2.142565869765625e-07 / 0.024620616607439628
635 MDC1_2 6_30711769_A_C / 6_30704316_T_G 0.006463206071893797 / 0.0019882207404644673 0.0020262441930086923 / 0.0013599597266763966
636 DYRK1A_3 21_37420484_TGGG_T / 21_37506256_A_C / 21_37505200_T_G 0.006470184695707864 / 0.007166152604563953 / 0.0018009306683812387 0.004141112427822946 / 0.023367448843283026 / 0.006729513952629108
637 SMPDL3B_2 1_27949055_T_G / 1_27956116_T_G 0.00686332660241626 / 0.005864140422713154 0.0015905760666496795 / 0.0137996143213625
638 EVPL_2 17_76023471_A_C / 17_76023459_T_G 0.007000637494837062 / 0.0007672223327735785 0.005291001652021031 / 0.010508474240463184
639 TOM1L1_5 17_54914767_TA_T / 17_54930294_T_G / 17_54936619_A_G / 17_54936871_A_ATTAAG / 17_54949462_TAAAAG_T 0.007038383297527345 / 0.0050109411285773646 / 0.00021710780579647815 / 0.00028231096361921765 / 0.00012667235189768908 0.04878127910267323 / 0.03275406093703293 / 0.014250045450198362 / 0.01731618533169237 / 0.009468652758198769
640 PPP6R2_6 22_50437806_T_C / 22_50444323_CT_C / 22_50438097_C_G / 22_50439767_G_A / 22_50444161_G_A / 22_50435068_C_T 0.007051784222833177 / 0.023269327181446267 / 3.439001444964778e-05 / 7.581666224780631e-05 / 3.643039740627613e-05 / 0.0008291832461198612 0.0008491344323951777 / 6.519259302157606e-08 / 0.02539141451283096 / 0.0453099522882128 / 0.048741469250829166 / 0.04553862958411738
641 DAB2IP_2 9_121772524_T_G / 9_121760326_A_C 0.0070915742180131395 / 0.007778717869708281 0.02191587566106909 / 0.01751891495836218
642 WRN_8 8_31096749_C_T / 8_31124455_G_T / 8_31141606_C_T / 8_31167122_C_T / 8_31068263_T_G / 8_31096728_GT_G / 8_31081188_G_A / 8_31154721_C_G 0.0071839350828315045 / 1.9744778112725726e-06 / 3.7195190403966525e-05 / 0.0005948019596535545 / 1.4689350346055224e-05 / 0.009117602293234885 / 4.455137121499956e-06 / 0.015467137724934844 0.015593392890488516 / 0.0002318154176456728 / 0.000309347551379363 / 0.008293074145156037 / 0.01874901447901884 / 0.0010432049093381938 / 0.02919802325158393 / 0.008229549817641594
643 SEC63_2 6_107876794_A_G / 6_107876670_C_A 0.007209006342709896 / 0.0019416198580565237 0.0015670897229372802 / 0.02957724273333363
644 MAU2_6 19_19336127_G_A / 19_19338794_G_A / 19_19338877_G_T / 19_19342712_T_G / 19_19342751_C_A / 19_19344019_G_A 0.007212671514055286 / 0.000960361991019274 / 0.0009059794395416026 / 0.0008876467494768484 / 0.0008876467494768484 / 0.001002378802893851 3.528738486135461e-07 / 1.9278481053706903e-06 / 3.174590417336852e-07 / 1.942933711490239e-07 / 1.942933711490239e-07 / 3.6691446641905493e-07
645 CDCP1_3 3_45091085_A_T / 3_45091145_T_C / 3_45095296_A_G 0.007224118191596861 / 0.003521903825993761 / 7.820303910973087e-07 0.01528693636083844 / 0.0025128061409562703 / 0.034457598045182634
646 NKTR_2 3_42630618_G_C / 3_42636885_C_A 0.007397151891706983 / 0.004629789663279317 0.0027059941965995107 / 3.766470432445502e-05
647 GSN_3 9_121321305_A_C / 9_121326911_A_C / 9_121282717_C_T 0.00754758939906495 / 9.99197364773904e-05 / 0.008701863324990747 0.0036521684936499576 / 0.014858234163842209 / 0.04144642618836994
648 MTR_3 1_236885200_A_G / 1_236897645_CT_C / 1_236812798_T_G 0.007571674596968512 / 0.00019121697493807043 / 0.006559116282295972 0.013876029031175869 / 0.019195378846888603 / 0.028819324921187783
649 DNAH1_4 3_52395506_T_G / 3_52398167_T_C / 3_52375405_A_G / 3_52394972_C_A 0.007807586400497246 / 5.188940804112937e-07 / 0.028701683809333287 / 0.04830043674512241 0.020152041638368784 / 0.04601002692990365 / 0.006840623405991567 / 0.005200470677837818
650 NDUFS7_6 19_1388539_C_T / 19_1389518_C_A / 19_1390758_C_A / 19_1391101_A_C / 19_1387920_T_G / 19_1387934_A_G 0.007902298175424828 / 0.01802139597834927 / 0.005968824663343653 / 2.816150837753928e-07 / 0.0031818920109542336 / 0.02651542479567508 0.004445598304300863 / 0.004267266689815653 / 0.007929745168935362 / 0.02277060279294577 / 0.0061684138287453226 / 0.0002841985871883526
651 TLN1_4 9_35711809_G_T / 9_35712826_G_A / 9_35700530_A_AGTTT / 9_35707057_C_T 0.008212937465719947 / 4.3027034258145176e-05 / 6.892028990051384e-06 / 1.5583116688212289e-06 0.03705209858981909 / 0.019628446580987526 / 0.03215388610263167 / 0.026823292872806558
652 PARPBP_3 12_102164766_G_C / 12_102165930_A_C / 12_102195841_T_TTAAAAA 0.008239841603573375 / 0.048432585939195916 / 0.009577111829889028 9.259289657162176e-05 / 0.0008692851756599481 / 4.1069065265654646e-06
653 FZD6_2 8_103300204_A_G / 8_103318860_G_C 0.008531191339496548 / 0.00031326302687667253 0.02679919317294273 / 0.01810032651868897
654 ITPR1_10 3_4651972_C_T / 3_4673329_A_C / 3_4712028_A_G / 3_4814550_G_A / 3_4645814_T_A / 3_4652327_G_A / 3_4653996_G_A / 3_4717319_C_T / 3_4652159_T_G / 3_4516699_C_T 0.00859416859519535 / 0.0036591352908788796 / 0.002472562485621646 / 0.0007540687837519184 / 1.174056333280529e-06 / 1.6973582056331476e-05 / 0.00018073915749960563 / 0.025102582779245618 / 0.0060202139881954326 / 0.01485572695651343 0.02221500748211688 / 0.028276024726866744 / 0.031417032356405285 / 0.020003750528966732 / 0.02165052204755015 / 0.04826424992681114 / 0.04219875731949733 / 0.00956347809995603 / 0.032544122080128725 / 0.04748127629652489
655 LAMA5_11 20_62307035_T_C / 20_62308863_T_C / 20_62315711_A_C / 20_62325178_T_C / 20_62327158_G_A / 20_62327540_T_G / 20_62310033_T_G / 20_62327738_A_C / 20_62332572_T_G / 20_62327734_A_C / 20_62345568_A_G 0.008632920752406494 / 0.014295751572041776 / 0.02909024968748458 / 3.555862255130917e-08 / 2.9240346346210547e-06 / 0.00712140384613043 / 1.5666190990300454e-05 / 0.019613193736301028 / 0.03355260503997278 / 0.034148373295335904 / 1.0743773421509558e-05 0.008839994985818419 / 0.003401604212977075 / 0.0003409731985327621 / 0.010970601799299722 / 0.037454561614064526 / 0.04839717926265442 / 0.00011553533752570969 / 0.00016041497097470358 / 0.00634985461358608 / 0.00014957483336764524 / 0.02125937044218393
656 MAPRE2_2 18_35132001_G_GT / 18_35070377_A_G 0.008697538540744818 / 0.0008936827603968188 0.027950082818089944 / 0.013874344261478143
657 PCM1_14 8_17938873_A_G / 8_17938874_C_T / 8_17947156_G_A / 8_17957171_G_C / 8_17962063_C_T / 8_17962252_A_G / 8_17972247_C_CAA / 8_17993739_C_A / 8_18010736_C_A / 8_18014089_T_A / 8_18014110_A_C / 8_18027462_G_A / 8_18027582_T_C / 8_17963329_A_C 0.008797381653836422 / 0.008797381653836422 / 8.592105380343799e-09 / 9.956680768337928e-13 / 6.195811157969624e-08 / 1.8937727055349602e-07 / 0.012906783621554044 / 0.00024859599240286334 / 0.0005752822575338514 / 1.5559989504674227e-05 / 2.7991275648315256e-08 / 1.0617795138512517e-06 / 1.3096196909220091e-08 / 0.013270249004941498 0.0286880097933444 / 0.0286880097933444 / 0.005755604603604279 / 0.003664181277087841 / 0.003941798080137453 / 0.000146676782393952 / 0.003377252281952908 / 0.0004892784845984415 / 0.01725609483145887 / 0.00016889400218637822 / 0.0005696202104790463 / 5.9466930864771254e-05 / 0.0032089265919612235 / 0.004113314671783447
658 LAMC2_2 1_183207851_G_T / 1_183207864_G_T 0.0090311817049441 / 0.0010913836051824374 0.02500420336879176 / 0.034260068788679536
659 FAT1_2 4_186706505_TAAAAAA_T / 4_186628213_A_C 0.009108698459398929 / 0.008101657943453211 0.02585265305545377 / 0.01860566173117391
660 SQSTM1_3 5_179833009_G_A / 5_179822433_T_C / 5_179832842_G_C 0.0096926694417795 / 0.004856219591816439 / 0.0277352874184494 0.03979973429187952 / 0.0024949336391905503 / 0.0024314650981475784
661 CCDC25_3 8_27736133_T_C / 8_27740525_GA_G / 8_27740655_A_G 0.009721303652590912 / 0.0012870249285031976 / 0.019736174159448082 0.012214514779241077 / 3.013644227200994e-08 / 0.009242113446549792
662 PTGFRN_2 1_116949272_C_G / 1_116985006_T_C 0.009786238032301352 / 0.0007152254747991232 0.04386987327886 / 0.015007302908998025
663 CUEDC1_2 17_57872703_C_T / 17_57873465_G_A 0.010263213673294223 / 0.0029406902030506186 0.0013582824059236026 / 0.00965828204249475
664 POLR3D_5 8_22247989_T_C / 8_22247116_G_A / 8_22247770_T_C / 8_22250473_A_G / 8_22245170_T_G 0.010361813952662016 / 0.040760845043798406 / 0.010265363996485286 / 0.010265363996485286 / 0.03202227743017228 0.0015081231813274575 / 0.0005996811951877831 / 0.0014851724380103976 / 0.0014851724380103976 / 0.0034846025589736784
665 MDN1_10 6_89661483_G_A / 6_89662267_C_T / 6_89680724_C_A / 6_89712908_G_C / 6_89728912_G_T / 6_89745710_T_C / 6_89819438_A_G / 6_89819440_C_G / 6_89819446_A_G / 6_89656810_T_C 0.011142557737209857 / 0.019733545814518076 / 0.00671054318104286 / 0.009319633314546674 / 0.029067614736169964 / 0.014718502010945343 / 0.03726926768860217 / 4.658109373380921e-05 / 0.00043794075690144836 / 0.001077236984005633 8.702195141061847e-05 / 4.241840867716095e-05 / 3.792323014139115e-05 / 0.002381685713249437 / 0.003051989681616468 / 0.0024784505977437274 / 0.002315253787970113 / 0.00030565312846269634 / 0.0005358395597195241 / 0.045388379703494304
666 ZNF407_5 18_74635526_T_C / 18_74881076_C_G / 18_74881080_A_C / 18_75064165_G_A / 18_74881141_G_A 0.01132130975657727 / 0.03691411059827635 / 0.002564188916256107 / 0.00027018930993972406 / 0.0024107982547803396 0.0030145474545959137 / 0.009890224680183182 / 0.03975077518004473 / 0.0037574487440396095 / 0.018926593122392126
667 C18orf21_2 18_35977490_T_C / 18_35973023_A_G 0.011570265284110644 / 0.04350573719131977 8.814319140246499e-05 / 0.009001638536085271
668 DNHD1_2 11_6566998_G_A / 11_6502909_T_C 0.01157615377505105 / 0.024706472106323003 0.003441011845932656 / 0.0051368432267910715
669 KCNQ5_2 6_72622312_C_G / 6_73194868_A_C 0.011667048329227513 / 0.008556892857902195 0.005821769162034106 / 0.002035847347947271
670 USP7_3 16_8916969_T_TA / 16_8921401_T_C / 16_8919178_A_G 0.011921515809972538 / 0.0007259106255980508 / 0.00985787434616614 0.007935686984078177 / 0.03489258945527392 / 0.01271404693174776
671 KRT19_2 17_41524128_T_G / 17_41524420_C_T 0.012145831162385651 / 0.02329208372328466 0.006794604788851329 / 0.0075159453943370955
672 CHD4_2 12_6598281_A_C / 12_6596093_T_C 0.0122076861217219 / 0.004382346617449564 0.0023450404288739924 / 0.005341196474657028
673 TRIO_5 5_14270972_A_C / 5_14380924_T_A / 5_14287139_AT_A / 5_14485052_GTTTT_G / 5_14304660_GA_G 0.01228372579415868 / 3.324291735916414e-05 / 0.01866091088461598 / 0.0021188750196952637 / 0.001000539371629746 0.0041763005884629285 / 0.009266068007448034 / 4.1269944199248776e-05 / 0.00011802420018250479 / 0.0066869864395857175
674 NR2F6_3 19_17232488_A_G / 19_17240807_T_C / 19_17240813_T_C 0.012426826069594731 / 0.008405600723765323 / 0.0104569397340928 0.0005711072972571918 / 0.006907234943082266 / 1.728226736131038e-05
675 HNRNPH1_2 5_179621204_T_C / 5_179614784_GAAAAA_G 0.012466319116509934 / 0.03611121611218025 0.0008981889773064157 / 0.009729395921872941
676 POLDIP3_2 22_42585672_T_C / 22_42585502_A_C 0.012811765150489051 / 0.04394982419601543 3.6252104008481515e-06 / 0.004353728585767742
677 CASKIN2_4 17_75501358_G_A / 17_75501713_T_C / 17_75503616_T_C / 17_75508335_T_C 0.01313679969802845 / 0.0005650477736965628 / 0.0014275310574789414 / 0.004128633364054907 0.002427426610400476 / 0.00023272703416067725 / 0.00689117538932749 / 0.024705224854909082
678 ZNF557_3 19_7083618_A_G / 19_7083750_A_G / 19_7074861_G_A 0.014332802500416091 / 0.016198364111666076 / 0.009991664044269358 1.6329734686551152e-07 / 4.640996358288638e-07 / 0.019872633283012617
679 BPTF_2 17_67825365_C_T / 17_67911547_C_G 0.01437455334956587 / 0.027807620738219758 2.5754103071800682e-05 / 0.006958200054189394
680 UGGT2_3 13_95833163_A_G / 13_95853698_T_C / 13_95860933_T_C 0.015116310313098947 / 0.037400522782126695 / 0.007496186466991611 0.000224596103770692 / 0.0011686091908779301 / 0.002068524896740717
681 FNDC3B_3 3_172362611_AT_A / 3_172328905_GT_G / 3_172286041_CTTTT_C 0.015509630370521969 / 0.002266663581871069 / 0.0003779941256659541 0.0007669696976411361 / 1.7757436099968484e-05 / 0.031871180713847265
682 CLIP1_3 12_122328152_A_C / 12_122328157_C_T / 12_122328162_C_T 0.01554438347868009 / 0.004768276278894758 / 0.002667521200669866 0.002481037749459045 / 0.041472618812521435 / 0.048511002649469816
683 TNKS_6 8_9680125_G_A / 8_9720284_A_AT / 8_9720294_C_A / 8_9735571_A_C / 8_9751720_A_C / 8_9766458_A_C 0.015553063070783985 / 0.021640953132470588 / 0.009525586921605824 / 0.006640140033620625 / 0.006977786341777385 / 0.032727629530903864 1.1196019412041484e-09 / 6.428366457977679e-07 / 9.234432766615335e-08 / 4.809045747636942e-06 / 0.019396751254115357 / 9.650265166072016e-07
684 NAA15_2 4_139349721_G_A / 4_139349435_AT_A 0.01573160679440035 / 0.003429044586968857 0.0002098904518747522 / 0.002911064627846368
685 RANBP3_5 19_5928023_T_G / 19_5928174_T_C / 19_5915583_A_G / 19_5925847_A_C / 19_5978199_C_T 0.01583040778996785 / 4.474815722770587e-05 / 5.7769976083466666e-05 / 0.0026896515436457035 / 0.007526230369901563 0.009045897483820205 / 0.0004179910655369823 / 0.03657225828634877 / 0.013386174688145538 / 0.043887995871297616
686 CCP110_6 16_19536035_A_G / 16_19536181_C_T / 16_19545945_C_T / 16_19541861_T_C / 16_19536052_C_A / 16_19548016_T_G 0.016159655378318708 / 0.04502177918333454 / 0.008022125809200288 / 4.851993209582035e-06 / 0.0004153878057481152 / 0.025513237898367132 0.00016378049017362915 / 0.0005567133937571787 / 0.0006179187799490345 / 0.015929257083152543 / 0.0007996357401027085 / 0.009536820248258198
687 ANXA11_2 10_80166029_C_T / 10_80161797_T_C 0.016605419991514502 / 0.0051164435438795204 0.007800123858178394 / 0.0013053025194313356
688 PLEC_5 8_143935900_T_G / 8_143916360_A_G / 8_143918739_A_C / 8_143929244_A_C / 8_143934289_T_G 0.01665471808934805 / 0.0034243187807631525 / 0.0018067465091272969 / 0.0008521926558447601 / 0.0001319263889148404 0.0004960012901022363 / 0.00910116635228719 / 2.138708286444241e-05 / 0.04249632659180479 / 0.008202162742211878
689 PDHB_5 3_58429863_C_A / 3_58427942_G_T / 3_58430808_C_T / 3_58431043_T_TTTA / 3_58431689_C_T 0.016694590509161198 / 0.0034915452482365546 / 0.0014468501934601355 / 0.00012132584593612988 / 0.0014468501934601355 1.9636106867401007e-06 / 9.607912469556515e-06 / 1.1215690852590127e-06 / 4.480434017438887e-06 / 1.1215690852590127e-06
690 ABHD12_3 20_25307869_C_T / 20_25297964_G_A / 20_25301097_T_C 0.017594886478281925 / 0.043687457267011516 / 0.004129132243776882 8.56668297363822e-06 / 0.00227969505884927 / 0.0004270759204191932
691 TRAPPC8_10 18_31858057_A_C / 18_31913653_A_G / 18_31900873_G_A / 18_31900876_C_A / 18_31867505_T_G / 18_31907633_T_A / 18_31846589_A_C / 18_31871211_T_A / 18_31901115_GT_G / 18_31858058_CT_C 0.01811627325789324 / 0.0017149077087971164 / 0.007882909715425471 / 0.0003097530865800165 / 0.0017696529343949547 / 0.003408008625421304 / 0.0025767772792916893 / 0.020052128513604172 / 0.0014872998913138286 / 0.009626844127190594 0.006180390175955454 / 0.009898646981541573 / 3.5402082656175115e-05 / 2.004341589623153e-05 / 0.00036773660587014015 / 0.0008596942505949141 / 0.0019258630221215085 / 0.0005317253240119541 / 0.03754796616685669 / 0.003048367023556882
692 NARF_2 17_82488071_A_G / 17_82485433_G_A 0.018611831902577654 / 0.0032741374426950077 0.0015678226483248074 / 0.03776328708562675
693 RPL9_3 4_39454772_G_A / 4_39458104_T_C / 4_39457622_A_G 0.01872028096022281 / 0.038040018913816906 / 0.013766563241610607 0.004161577416808298 / 0.004570198384291764 / 4.793806278603332e-07
694 SENP7_2 3_101347873_T_A / 3_101513249_C_A 0.01892010828896953 / 0.027162288974149237 4.432034386075619e-05 / 0.00843965290168897
695 HERC1_4 15_63666001_A_C / 15_63666004_T_C / 15_63754569_A_C / 15_63706823_T_C 0.018947416114520832 / 0.012801946597404643 / 0.009094911651776984 / 0.0001905333488051304 0.0009552551098417773 / 0.0050390069990103115 / 0.007343118479360836 / 0.005050957906342418
696 DOCK11_2 X_118627539_A_C / X_118580020_T_G 0.019238892996198773 / 0.002446966159681028 0.00012436903410890539 / 0.02379391735060052
697 KLF5_3 13_73063987_G_T / 13_73062772_A_AGTGT / 13_73063986_TG_T 0.019354403860496208 / 0.037567154465037694 / 0.006314572274949971 0.008502737493358522 / 0.0008455054702052634 / 0.045197394376435635
698 FERMT1_2 20_6119441_A_G / 20_6076305_T_G 0.01953104506649206 / 1.5328575507414378e-05 0.003951008923557318 / 0.005589077504505465
699 CGGBP1_2 3_88056114_A_C / 3_88058700_T_G 0.019690640293771062 / 0.0001488078729312028 0.0013325718879930134 / 7.124415972693971e-06
700 CEP85L_4 6_118511157_T_C / 6_118565452_T_C / 6_118565798_G_T / 6_118652790_A_G 0.019951442705337254 / 3.4006295145334306e-05 / 0.006640489210238536 / 0.005690521125333515 0.0019936945989450267 / 0.031500707148776626 / 0.011376444437361329 / 0.01248838915032558
701 TCF4_7 18_55585157_G_A / 18_55464257_C_A / 18_55463971_TGTGTGTGA_T / 18_55275657_A_G / 18_55403517_A_C / 18_55461237_G_T / 18_55234488_T_G 0.02005132938992895 / 9.139603483849228e-07 / 0.003907248287482544 / 0.04979553061082194 / 0.027277557605803925 / 0.004036463102105114 / 0.0005592100190603741 0.002362550141751555 / 0.032420073593804284 / 0.03333184670009802 / 0.0013930308437610063 / 1.5397131093463103e-06 / 0.04572000946513434 / 0.005926553123167896
702 DQX1_2 2_74518953_C_T / 2_74519195_A_T 0.02016550460713128 / 0.02345411840768387 0.001543466936969916 / 0.0012259823356569838
703 UBR5_3 8_102327653_A_C / 8_102288240_T_C / 8_102311353_A_G 0.02158342295983112 / 0.000182245886028422 / 0.002891650419980013 0.0014448817758050778 / 0.041616237854309936 / 0.00926532742682097
704 UBR7_2 14_93227076_C_T / 14_93227060_C_A 0.021764228343538142 / 0.00036547494521639036 5.580051554471299e-12 / 0.004489348973894868
705 PRDM15_6 21_41804523_A_G / 21_41857170_C_CT / 21_41878737_C_T / 21_41878845_C_CG / 21_41879218_C_A / 21_41860296_C_G 0.022209828018085867 / 0.0016831430872538335 / 0.001963497325920565 / 4.181886700329235e-07 / 0.0008539747138144563 / 0.003762939149636617 0.0024789131706555692 / 0.04559041805735448 / 0.004333100546220035 / 0.0014981405701937028 / 0.007033127481264185 / 0.003918924565748825
706 HPS4_3 22_26464303_G_C / 22_26466187_C_A / 22_26466246_T_C 0.023338960947810374 / 0.0034082024391394804 / 0.008599880725164986 0.00049975228288003 / 0.013660798942983977 / 0.013660798942983977
707 KIF13A_2 6_17759921_G_T / 6_17779691_GA_G 0.02351576585497226 / 0.0016700241845674759 0.005082432403932738 / 0.03874282920193672
708 SLC35B4_8 7_134294793_A_T / 7_134294800_C_T / 7_134294826_A_G / 7_134295043_T_C / 7_134296475_G_A / 7_134299375_A_G / 7_134300126_G_A / 7_134304791_A_G 0.02373113198705864 / 0.01698627709999008 / 0.006372984518535906 / 0.02196618128109366 / 0.0003440877501955943 / 0.006567115319239084 / 3.4006295145334306e-05 / 0.005046500727253695 0.007700956159853255 / 0.0033988992551489622 / 0.003846947305778054 / 0.003846947305778054 / 0.0005322435434420271 / 0.004732359355015072 / 0.00026123770283039777 / 0.0007109966209961128
709 L3MBTL2_6 22_41213686_C_T / 22_41221314_G_C / 22_41217184_C_T / 22_41217299_C_T / 22_41221156_T_TG / 22_41214238_A_G 0.02384699817673188 / 0.036506965435244586 / 0.00046243520821700383 / 0.0014542660494230402 / 0.0048712846790899276 / 0.009223190722677185 0.0010787186334203051 / 0.0001832674707524145 / 0.0038205423576211455 / 0.004209694792725524 / 4.2157738222413464e-06 / 0.04965109007915304
710 RAI14_6 5_34810866_G_A / 5_34811689_T_C / 5_34812303_A_G / 5_34812384_A_G / 5_34814795_A_G / 5_34826376_A_C 0.02398248389974741 / 0.003021738485801497 / 0.03016889098915158 / 0.04699754955019005 / 0.007276272312251042 / 0.03015590631046501 0.005930385895234786 / 0.02067007422009637 / 0.008963944637711066 / 0.0075054618188784596 / 0.002646842318515723 / 0.006485048570616563
711 ARHGEF10L_2 1_17632421_T_G / 1_17581112_C_T 0.02441616386812752 / 0.008405600723765323 0.00740919250255517 / 0.019746113249432044
712 WFS1_2 4_6300580_T_G / 4_6301666_T_G 0.024665242803626187 / 0.008957131401361508 0.0005139212842413073 / 0.005931412638336574
713 TPP2_5 13_102645085_CT_C / 13_102649187_G_T / 13_102629949_C_G / 13_102634223_C_T / 13_102645085_CTT_C 0.024741402723073853 / 0.028415295283801194 / 0.001061432461116305 / 0.03296472481201721 / 0.00032041277623460525 0.0017617933204615989 / 0.0003388682906380855 / 2.491492385425685e-05 / 0.0010859815068279958 / 0.04128722708381896
714 DPY19L3_3 19_32480317_C_T / 19_32482171_C_T / 19_32457979_A_AT 0.02575962131883935 / 0.041529928834727996 / 8.068330723796263e-08 0.00488668851811109 / 0.00656763144792808 / 0.0003669711749463792
715 SYNE1_13 6_152149487_A_G / 6_152310394_A_C / 6_152302141_A_G / 6_152350340_A_C / 6_152350418_A_G / 6_152350784_G_GA / 6_152350840_A_G / 6_152354719_A_G / 6_152373049_T_C / 6_152416413_T_G / 6_152352408_C_CT / 6_152326359_G_A / 6_152167902_T_G 0.02589202251594358 / 0.0068225672761204 / 0.018111885168250186 / 0.001534088782688901 / 0.00015349542079229654 / 0.003947934300958396 / 0.009039115199453142 / 0.0032281218393380826 / 0.034085027891066176 / 0.0074217808535962425 / 0.0003084243419514754 / 0.04013949097321684 / 0.007925318609942202 0.0022312687521415984 / 0.000300569048618415 / 0.000916091757381376 / 0.04334315784101184 / 0.025133645776259043 / 0.015037738599618973 / 0.049886685026608805 / 0.04777964311542563 / 0.003302156741579197 / 0.012499408296212235 / 0.002950466518563949 / 0.002843434249435789 / 0.025194372743123864
716 BAIAP2L1_2 7_98312162_T_G / 7_98310492_T_G 0.02645273506751201 / 0.017881464475754172 0.002108350377110309 / 3.1631490207583316e-05
717 CXXC1_4 18_50283881_C_G / 18_50283981_A_G / 18_50282775_A_C / 18_50285505_A_G 0.02700492420991353 / 0.00030830634455756233 / 0.00020363998830215009 / 0.024668590953954232 0.0054045514118498715 / 0.0069760254674185035 / 0.00041677651706905364 / 1.2396826716404366e-06
718 ITGB5_3 3_124769064_T_G / 3_124796789_C_T / 3_124809087_T_G 0.027271474201973192 / 0.0030628908663900517 / 0.02459057498205289 0.0006588536356118503 / 0.03655295537599197 / 5.4585187494895796e-05
719 BRD4_2 19_15255220_T_G / 19_15264730_T_G 0.02738257500091704 / 0.0024688743871748233 0.003128882089479218 / 0.012931811845921107
720 TUBGCP6_3 22_50218683_C_T / 22_50226183_A_G / 22_50216669_A_G 0.02873848846989375 / 1.7193787546395546e-05 / 0.001425645880342349 0.0032493001194240914 / 0.004608803965780261 / 0.0053976890998902035
721 SH2D4A_2 8_19373444_G_GTA / 8_19373444_G_A 0.029078590360841292 / 0.0012205889084294006 0.0029847738366696104 / 0.03439931765423256
722 UPP1_3 7_48088999_G_A / 7_48108129_C_G / 7_48108147_T_G 0.029144965782620207 / 0.015833254501378846 / 0.01682115524692246 0.0003765748447247093 / 0.0002337913556195707 / 0.0015081620173450355
723 WDR48_5 3_39068755_C_T / 3_39069649_C_A / 3_39066494_T_A / 3_39077046_G_A / 3_39052175_T_A 0.030420442989910295 / 0.044145461001922535 / 5.492585713676155e-05 / 0.00014207366024108895 / 0.015418219237359813 0.00013091692663621323 / 1.1291180538837308e-09 / 0.030704581537927867 / 0.04365312343408456 / 0.002516254064872987
724 PDS5B_5 13_32741072_A_T / 13_32758091_C_T / 13_32675925_C_A / 13_32710010_G_T / 13_32652145_GT_G 0.030726392282429425 / 0.00123879071402958 / 0.0006856670147522433 / 0.002121608222392312 / 0.0007921211551638221 0.001639201016530517 / 0.0023301391981286807 / 0.004241708828197667 / 0.017388913859398773 / 0.002787725341881676
725 AHNAK2_13 14_104948863_G_C / 14_104950348_C_G / 14_104952007_T_G / 14_104952054_C_T / 14_104954590_A_G / 14_104955559_A_C / 14_104949306_T_C / 14_104950948_C_T / 14_104946565_A_C / 14_104949318_G_C / 14_104953856_A_C / 14_104944923_A_G / 14_104945888_T_G 0.0308328381135858 / 0.016748316074642184 / 0.03839823545317707 / 0.03874915731384604 / 0.0072096008154851265 / 1.5768275144985015e-05 / 0.006402387188591212 / 0.006209224175079767 / 0.02197650841839336 / 0.005813098445302893 / 0.024214266407806717 / 0.0185888935199706 / 0.0006623043768660483 0.0037872773041585602 / 0.0010008042001551844 / 4.242877237542688e-05 / 4.758634079373864e-05 / 0.044213954062984784 / 0.00506490504122054 / 0.005256944789299486 / 0.009057439080581924 / 0.006657596405885244 / 0.015474300784924832 / 0.003500316527332319 / 0.004782218518041667 / 0.009471254952683202
726 PSIP1_4 9_15469426_TA_T / 9_15472613_GA_G / 9_15478664_T_C / 9_15473904_C_CA 0.03090002089985741 / 0.010885733995064931 / 0.0036412739882121493 / 0.019522544533840024 0.0021167351616768765 / 0.002781333210996778 / 0.04454350703768868 / 0.047598542315053116
727 ANK3_2 10_60140286_C_G / 10_60140292_G_T 0.031415751059474716 / 0.004915637551152243 0.006334167714527676 / 0.025015110862319518
728 PLEK_3 2_68380987_A_C / 2_68388306_A_G / 2_68380161_C_G 0.0317726416239668 / 0.008640427676032429 / 0.003025481684231003 0.0018651167043750433 / 0.012112306050675708 / 0.004442991541746456
729 HMGB1_2 13_30463652_C_G / 13_30465849_T_C 0.03226480417721332 / 0.0001648093940653516 0.0005823170484383475 / 1.5385023502599213e-07
730 ACTN1_2 14_68890121_A_G / 14_68904620_A_G 0.032894585296185316 / 0.002540635063275344 0.0030504600602986385 / 0.01924890787722053
731 FAM193A_2 4_2662705_A_G / 4_2659865_A_C 0.033419216681695084 / 0.04113816735227994 0.006119225115333783 / 0.002421422710409682
732 ALS2CL_3 3_46688267_C_G / 3_46671861_C_A / 3_46683906_C_A 0.03379224538431711 / 2.315014453759593e-05 / 0.005940717099935289 0.0010458636942191153 / 0.016517080453509674 / 0.048512125386189216
733 SMARCA5_3 4_143521582_C_T / 4_143514027_G_A / 4_143513907_T_G 0.03389913212461259 / 0.0005336701932334038 / 0.00047650766195259835 0.009752627346239709 / 0.0006586181076668231 / 0.004556295949163353
734 TMBIM1_4 2_218278506_G_A / 2_218278604_T_C / 2_218279426_G_A / 2_218282145_T_C 0.03396031249525595 / 0.02844679337110864 / 0.0068961961974542295 / 0.0018492744109954121 0.002273449490648745 / 0.0012042001777173455 / 0.0022480783740468167 / 0.030530266212098117
735 ZNF236_5 18_76959812_T_C / 18_76968158_T_C / 18_76968252_C_T / 18_76936580_G_T / 18_76968514_A_G 0.034863364756142684 / 0.00544264119615534 / 0.007385442293655849 / 1.258127500782992e-05 / 0.001396157570840323 0.004671655781344212 / 3.359123080186937e-06 / 3.816383122507129e-05 / 2.2508576141383803e-05 / 0.00014020410621502926
736 DMAP1_3 1_44213884_A_G / 1_44219323_T_C / 1_44214487_A_C 0.03508585380179657 / 0.0001543183975019544 / 0.000996146741984629 2.797176359518221e-05 / 0.04898236049763705 / 0.041077293102317024
737 GIT2_2 12_109951210_A_C / 12_109952676_A_C 0.038020170939281527 / 0.044654978525331915 0.0015711134341594402 / 0.0073535263645836966
738 PBRM1_4 3_52642049_CA_C / 3_52642048_AC_A / 3_52642050_A_T / 3_52658412_CTT_C 0.03826328245790342 / 0.003417708183485354 / 0.003417708183485354 / 0.004371631368875628 0.0014123627803440367 / 0.00010786476378721626 / 0.00010786476378721626 / 0.04797045127180218
739 SEMA4B_3 15_90230550_C_T / 15_90219735_T_G / 15_90223369_T_C 0.0382907038385724 / 0.00014017436078508742 / 0.003606528003523896 0.003576989974401659 / 0.0196110620734337 / 0.012423711849739305
740 CDH1_2 16_68823310_T_G / 16_68810107_C_G 0.03866739925480673 / 2.3568872507011226e-05 0.0025541666878341144 / 0.0045199561560194616
741 PAK4_3 19_39176740_T_C / 19_39178411_T_C / 19_39178960_A_ATG 0.03964657176847531 / 0.0031968419187330646 / 0.00031366512220605466 0.0005253339462112416 / 0.012050619287225093 / 0.04112372072532399
742 KDM5A_2 12_310904_G_A / 12_323658_C_A 0.040083104628847975 / 0.03485434053230182 8.99232571405919e-08 / 4.775460326696479e-06
743 CHMP7_4 8_23249152_A_G / 8_23260130_T_C / 8_23260642_T_C / 8_23255149_C_T 0.040858161657175214 / 0.0021955959993491484 / 0.001347026932454516 / 0.005979199546716722 0.00985156252549634 / 0.007951126415472621 / 0.005852678740537498 / 2.528028640474925e-05
744 FASTKD1_2 2_169557305_CA_C / 2_169557305_CAA_C 0.04142328785089491 / 0.016746895905411573 0.00016945881737810868 / 0.003864236188058555
745 MRPL39_5 21_25587877_T_G / 21_25588774_T_C / 21_25594005_A_G / 21_25603938_A_G / 21_25607316_G_A 0.04194490101459973 / 0.01937493996228174 / 0.01845646940649424 / 0.02800309093409305 / 0.00630118834188515 5.7418126731545284e-08 / 3.6929628125728576e-08 / 2.5701269842959545e-08 / 1.0577675519010665e-08 / 3.688861166466308e-08
746 PON2_2 7_95406313_A_C / 7_95406317_T_C 0.04295809677939748 / 0.03518057074232925 9.367508145310504e-06 / 9.041805671182428e-07
747 ATP9A_2 20_51608625_A_C / 20_51627544_T_G 0.0453107586125816 / 0.0033064577154371753 0.0016205979394364285 / 0.046011362965187
748 SYNE2_3 14_64189964_AT_A / 14_64022731_CT_C / 14_64122119_G_A 0.04554515566635235 / 0.0259958042872378 / 0.005029743152006167 6.34029580306576e-05 / 0.003556496243260812 / 0.031891035954103614
749 EXD2_2 14_69236592_C_T / 14_69236597_G_T 0.045815872520569866 / 0.007261223228798206 0.006743325380355538 / 0.009984452523516405
750 USP22_9 17_21002832_G_C / 17_21002938_C_T / 17_21002944_A_G / 17_21005012_T_C / 17_21018179_C_T / 17_21021210_G_A / 17_21021307_T_C / 17_21028347_G_T / 17_21043080_T_C 0.04602479247359704 / 0.008276359973551 / 0.0003145539245206166 / 0.00013159988064048868 / 0.00017641068386537028 / 0.00018037842009303046 / 0.002766843921558569 / 0.00965100020152009 / 0.0021915580128042123 5.2405530742318296e-05 / 0.0001522332352001979 / 0.0010200867803667195 / 0.0002608036035294038 / 0.0002258154609608441 / 0.00012857609143244398 / 4.777859944106238e-06 / 0.001140393407840919 / 0.01642994041963463
751 R3HDM1_2 2_135621624_GT_G / 2_135661361_A_C 0.04643229751040803 / 0.01096218490346052 0.007933574405897037 / 0.00075038338644858
752 LAIR1_2 19_54364274_T_C / 19_54364717_T_C 0.04672350230262375 / 0.015465209925053043 0.008257714587898193 / 0.006617848488520711
753 EVL_5 14_100126634_T_G / 14_100132827_G_A / 14_100126622_G_A / 14_100132645_T_G / 14_100135917_A_C 0.047372429474904484 / 0.0016660544745078804 / 0.004134369004838065 / 0.00016640135361204822 / 0.0031029134247096963 4.756430435799507e-06 / 0.00563219201718044 / 0.01997007957497231 / 0.026704266687616097 / 0.006469582595095918
754 RNF123_2 3_49714152_C_T / 3_49700145_G_T 0.047756940070976237 / 1.1366734297895966e-06 0.00816572334990732 / 0.0037608177292696564
755 DNMT1_2 19_10162649_G_A / 19_10143809_G_C 0.04804143143713783 / 0.022663915935835485 0.0013474327860987167 / 0.0054179883970128856
756 BTBD16_4 10_122275013_G_T / 10_122275188_T_C / 10_122285973_C_T / 10_122291060_G_A 0.04876523124872777 / 0.04476796806488366 / 0.00874169822078938 / 0.03049550442980961 0.0003520007001970831 / 0.00020893956494733148 / 0.0013169765604353282 / 0.0026073441109972398
757 FUCA2_2 6_143504166_C_A / 6_143507227_A_G 0.049200639651661375 / 0.029895339238934462 0.00639339868461808 / 0.0054745403112583324
758 PPIP5K2_3 5_103201499_T_G / 5_103201584_A_G / 5_103201656_T_C 0.04957254295359858 / 0.00015517194478671765 / 9.016600091479696e-05 0.00015030812167049831 / 0.020151832289907558 / 0.029631285544831236
759 TIMM44_3 19_7932571_A_G / 19_7932574_T_G / 19_7932577_T_G 1.3167297251695571e-05 / 0.0003422957438462025 / 0.0005904858316322034 0.02845639919448445 / 0.006688970144575634 / 0.006057634937627619
760 MEX3C_2 18_51196847_C_T / 18_51196775_CGCCGCCGCG_C 1.329885109524148e-10 / 0.0022225090338153708 5.249784413332885e-07 / 0.01963887463995091
761 MTUS1_3 8_17754377_G_A / 8_17755366_A_G / 8_17721812_A_C 1.3576985363683765e-05 / 1.972258766974004e-08 / 0.02629101974751153 0.001701316781434502 / 0.026616233857667596 / 0.002181030051469235
762 CTSH_2 15_78922969_A_C / 15_78939184_A_AG 1.4037598311677378e-05 / 0.0001924278188105154 0.010345021977573308 / 0.0344244477250216
763 IL18_3 11_112150193_T_G / 11_112155193_G_C / 11_112155192_T_C 1.461260124702572e-05 / 7.96641505141555e-07 / 0.03134154150698633 0.012472744364369587 / 0.011978242096605442 / 0.007248539214372238
764 ZNF654_2 3_88139270_G_A / 3_88140191_T_C 1.4751691487034687e-06 / 2.0819038805248358e-07 0.0018019171147236148 / 0.0019048877551503765
765 ZNF589_6 3_48241161_TGCGC_T / 3_48241205_A_G / 3_48257949_T_C / 3_48268338_C_G / 3_48286239_T_C / 3_48286261_G_A 1.6889590876869102e-06 / 1.1715920482680521e-06 / 7.920379942105592e-05 / 2.8491798121821795e-05 / 1.5027613326502343e-05 / 7.796162715352446e-06 0.0007986098597650371 / 0.0010457901523321454 / 4.006095509659407e-05 / 0.0020191705610664206 / 0.001627877596998014 / 0.0011919391649323414
766 EPS15_6 1_51361249_T_C / 1_51405766_G_GACTC / 1_51440277_CTGTG_C / 1_51463832_TA_T / 1_51472751_T_G / 1_51461237_G_A 1.6925862398730225e-06 / 4.1443509369940415e-05 / 0.031894015484001656 / 3.0950467922083264e-06 / 0.02951071302033457 / 0.01032478965873057 0.0002615744055786565 / 0.0005725418098281438 / 0.00017362501014406024 / 0.0002615744055786565 / 0.0045422702652321255 / 0.0029577065864897127
767 ZNF266_2 19_9413509_A_G / 19_9420011_TG_T 1.7177250175637761e-06 / 0.04040969628183889 2.6110373221371133e-14 / 0.004948136499581445
768 BCAM_2 19_44820881_G_A / 19_44811510_C_T 1.7938533698319987e-05 / 0.0006276370995178965 0.006588412083819078 / 0.021875016141096045
769 C3orf38_3 3_88150029_T_C / 3_88150035_T_TC / 3_88150148_T_C 1.7996666116084316e-06 / 0.00014178936922186315 / 2.595905755446793e-06 6.57647003118834e-05 / 4.649030455483649e-05 / 7.105213671060247e-05
770 ERICH1_8 8_659132_C_G / 8_657766_C_G / 8_658018_C_T / 8_666590_T_A / 8_673593_G_A / 8_715858_C_T / 8_659879_A_C / 8_659039_G_A 1.8121573621263876e-05 / 0.0010420319235614432 / 0.04660176454698252 / 0.004834244365989843 / 0.007260620745344446 / 0.04859602375702362 / 0.0025352106440479803 / 0.002455544576447661 0.0054140514901705895 / 0.043640948824396286 / 0.0013028832620993098 / 0.018154111038570942 / 0.01865482112843118 / 0.00034437810537597347 / 0.0461414202945825 / 0.014420687330437538
771 LSR_2 19_35267372_G_GGGA / 19_35267177_A_C 1.823380047726112e-06 / 0.03651632235421607 0.0021105674130373147 / 0.0028831204631532326
772 PIK3C3_3 18_41955191_C_G / 18_41955194_A_G / 18_42043978_A_G 1.9440372522869497e-06 / 0.0006320335833085862 / 0.023735103370508225 1.065744821934887e-06 / 0.0001342557450694381 / 0.00031280032152652704
773 TAF3_4 10_7824594_T_C / 10_8013652_G_C / 10_8013913_G_A / 10_8014532_C_T 2.0664435570944493e-05 / 0.004655883072306037 / 0.00943383216960874 / 0.0009463104379838767 0.03748233778862958 / 0.008249411816346357 / 0.004857051949006447 / 0.0014732747867095904
774 FNBP1_2 9_129909080_T_TG / 9_129923982_A_G 2.1184979283245958e-05 / 5.268485267589101e-05 0.013989753243576588 / 0.019443664939858312
775 SACM1L_14 3_45719623_G_C / 3_45722143_A_G / 3_45722754_A_G / 3_45723052_T_C / 3_45731250_T_C / 3_45731280_G_A / 3_45732240_G_A / 3_45737644_A_T / 3_45705344_A_G / 3_45706937_G_A / 3_45713257_G_A / 3_45712995_C_A / 3_45689454_T_G / 3_45739488_A_G 2.2026676208492585e-06 / 9.443816831049491e-07 / 0.0022018800476893614 / 3.5837125763699036e-08 / 4.4397997289151143e-07 / 1.2227532248856571e-06 / 1.3468374724431254e-06 / 7.150800554712763e-07 / 0.013551678428059705 / 0.0062092789567569535 / 0.0035804098855498063 / 0.005851841559996625 / 0.0028202119918153247 / 0.030877901512994674 2.7990310927885382e-05 / 2.6591646486392756e-05 / 0.006779520290921261 / 3.962907852818685e-05 / 1.1237814806460453e-05 / 4.359294069545172e-05 / 5.1558332133000766e-05 / 3.496973226569382e-05 / 0.0006684767742569695 / 7.302437009455565e-05 / 9.003284436221187e-05 / 0.005848457401461229 / 0.03994336344384322 / 5.7399601602553275e-06
776 TXNL1_3 18_56602813_A_T / 18_56626612_C_T / 18_56651278_A_T 2.210469276189849e-06 / 0.022001595468935316 / 0.02149358538709261 4.0417773765221675e-09 / 2.767068005468822e-10 / 1.7102012334179478e-05
777 PTPN3_2 9_109436866_A_G / 9_109406452_T_G 2.248398882883789e-05 / 0.008436388558613016 0.022560149794550868 / 0.025748841495573487
778 LAMA3_9 18_23861753_C_T / 18_23915519_T_C / 18_23946123_C_T / 18_23949758_G_A / 18_23954737_C_A / 18_23954739_C_T / 18_23939340_A_C / 18_23713905_CT_C / 18_23846109_T_G 2.2546401848550504e-07 / 0.0006963202810397933 / 1.582829210028338e-05 / 1.6534066895813288e-06 / 2.6769400746243374e-05 / 1.9933398900670928e-05 / 0.0008881294144847822 / 3.0126882423530804e-05 / 3.5426816292959363e-05 0.033914720695717084 / 0.013114315448110179 / 0.03066224880164858 / 0.025703076793439833 / 0.042551605063568684 / 0.030472466536971138 / 0.013225085724631118 / 0.01613050085470659 / 0.04009682047166014
779 MTMR9_3 8_11284836_T_G / 8_11309724_G_A / 8_11322815_A_C 2.349458678158868e-06 / 0.0004653758499732343 / 0.008022838484344897 2.4088220462781546e-11 / 0.0074905636429132404 / 0.008917788804222488
780 ITGA6_4 2_172427981_A_G / 2_172427985_C_T / 2_172484735_A_G / 2_172490965_G_T 2.55642040821661e-05 / 1.1751587238624405e-05 / 0.002854965230943433 / 0.025550057038402886 0.021886276374067117 / 0.023752544661456654 / 5.351259734935356e-06 / 0.007174810273459709
781 KRI1_8 19_10557707_T_C / 19_10558277_G_A / 19_10560316_C_T / 19_10565667_A_T / 19_10565747_G_A / 19_10561817_C_T / 19_10562664_C_T / 19_10565811_G_GCC 2.6474598014609052e-05 / 9.523794655306364e-05 / 0.00011786607794266038 / 0.0001616270444439651 / 3.4012624242046115e-05 / 1.477271100442178e-06 / 1.0798436673597302e-06 / 6.316959826240111e-06 0.00012897741560140272 / 3.792910022705542e-05 / 2.0569928046658807e-05 / 2.711645177509063e-07 / 3.211054485740389e-07 / 1.8153836897508705e-05 / 0.0002329401807770252 / 0.0008450486067550477
782 GBP3_2 1_89007941_G_A / 1_89011034_A_T 2.713567196210831e-05 / 0.047917709012617486 1.221534419837023e-06 / 2.259902209453749e-08
783 FGFR2_2 10_121487530_T_C / 10_121520352_C_T 2.796050535454376e-05 / 9.346629403777272e-05 0.015364585786772819 / 0.004955596968571121
784 TNRC6C_2 17_78049826_A_C / 17_78067796_A_G 2.865420177578161e-05 / 0.003859622145256892 0.03771979541922566 / 0.03295200627528048
785 PDGFRB_2 5_150135511_G_A / 5_150129967_A_C 2.9565587793102473e-05 / 0.0011142332419287124 0.007951396082365123 / 0.010884978116376998
786 ASPH_2 8_61578734_T_G / 8_61638365_TA_T 3.0349566769525607e-06 / 0.014784455717628972 0.00027481062695969863 / 0.0033421074285719613
787 MRPS25_2 3_15065217_A_C / 3_15065038_A_C 3.231333497421803e-05 / 0.03913000849637771 0.0017607662142123156 / 0.008302391831822605
788 CNIH4_2 1_224356827_A_G / 1_224379302_G_A 3.345540294148141e-05 / 1.3298114540105321e-05 8.270232693194595e-06 / 0.004957072960670954
789 STAT5B_2 17_42212246_T_A / 17_42218217_T_TG 3.457612678303974e-05 / 0.009108698459398929 0.049805612849012526 / 0.041598649064757576
790 NRF1_5 7_129690176_C_G / 7_129709261_G_A / 7_129710330_A_C / 7_129711604_C_G / 7_129717099_T_G 3.514964941916984e-05 / 0.0012574856804500286 / 0.0029569614211133396 / 0.0009106050710647207 / 0.0008333980926761285 0.0008588680251565 / 0.0020358531276104324 / 0.001863531871592876 / 0.00048643171799331433 / 0.006420212881434713
791 C21orf58_2 21_46302477_A_G / 21_46322980_A_AG 3.600317129022087e-06 / 0.000178616399448272 0.028316032350682373 / 0.0464048927112107
792 EBF1_2 5_159099526_TA_T / 5_159099526_T_TA 3.7020844162640586e-06 / 0.0061991425888554795 6.309766911659592e-06 / 0.009920112112628023
793 PCNT_10 21_46438359_T_C / 21_46440304_C_T / 21_46442711_A_G / 21_46444647_CTTT_C / 21_46444900_C_T / 21_46444910_G_C / 21_46355631_G_C / 21_46425893_A_C / 21_46444675_T_G / 21_46444677_T_G 3.8924131898677556e-05 / 0.00010294155569212726 / 0.00442543345514155 / 0.0007255960816556072 / 2.666879695038341e-05 / 2.666879695038341e-05 / 0.045239341586552524 / 0.0052653795831940926 / 0.011583428163992472 / 0.0012373038631552345 0.0007850146452497258 / 0.0011784720417395535 / 0.0010237263069919882 / 0.01824823490083048 / 0.00036147873774628185 / 0.00036147873774628185 / 0.0004512031541319047 / 0.01998375792506145 / 0.009046665740785187 / 0.01284951528238673
794 RFT1_3 3_53104238_T_C / 3_53120116_ATTAACTGCAC_A / 3_53120127_T_G 4.1039519054300644e-05 / 0.010916191776172972 / 0.0009241739865608092 0.019143884189355254 / 0.0012736601162827682 / 0.0003755806923286365
795 NGLY1_4 3_25733865_A_C / 3_25736073_G_T / 3_25764388_T_C / 3_25732334_A_C 4.193690016854428e-05 / 1.0629890346566115e-06 / 0.00018111373229034528 / 0.000337635257557846 0.004048589804059987 / 0.0001003348545752524 / 0.008193558074218642 / 0.0008517116761761035
796 SHPRH_2 6_145955343_T_G / 6_145922945_GT_G 4.197525341776357e-06 / 0.02497921302813516 0.0019437040989644704 / 0.0032085441168495693
797 PSAP_4 10_71817510_G_A / 10_71820222_G_A / 10_71823763_G_C / 10_71825769_A_G 4.253559292570684e-05 / 1.4584188008395623e-05 / 0.0007450217858733059 / 7.15024619363838e-07 0.005989723973244358 / 0.004815444492138627 / 0.005093191498317171 / 0.001137729147313085
798 EPG5_4 18_45907942_A_G / 18_45860332_T_G / 18_45967161_TG_T / 18_45949582_G_A 4.41056482155363e-05 / 0.0325761410753079 / 5.0265150457437094e-08 / 0.0009686733993730644 0.00018099150138285703 / 5.454441871402812e-06 / 0.0031405068156816515 / 0.04928013785599337
799 GRB7_2 17_39746744_A_C / 17_39737973_T_C 4.445333626793725e-06 / 3.7814817628535414e-05 0.015646545098240962 / 0.0275943135807812
800 TBC1D5_5 3_17233681_G_C / 3_17238034_T_C / 3_17258641_A_C / 3_17428395_ATG_A / 3_17238102_T_G 4.500069192335354e-07 / 5.287266410953234e-06 / 1.0934340959097885e-06 / 0.00038136339583758066 / 0.0015374412890621536 0.034850654424783314 / 0.048246561657752436 / 0.034850654424783314 / 9.180133184684152e-05 / 0.00428366923460265
801 TTLL3_5 3_9825941_C_T / 3_9826893_A_G / 3_9829346_T_G / 3_9832986_G_A / 3_9835303_G_A 4.506908857236149e-08 / 9.62440960091469e-07 / 6.721794266994746e-08 / 3.966565971028462e-07 / 0.047234941799100816 0.004512931116648239 / 0.009182452462015591 / 0.0016666988915567758 / 0.005845443747610279 / 0.00549007437147901
802 HAUS1_4 18_46118343_C_T / 18_46123257_C_G / 18_46122767_C_T / 18_46118217_A_T 4.791384820535998e-09 / 9.485176947904584e-06 / 0.0008672645013724843 / 0.00028116915718734436 0.0017369506644946814 / 0.009435638863427392 / 0.00147832294217736 / 0.0031860563996751264
803 FGD4_3 12_32640343_A_C / 12_32640545_A_C / 12_32582270_A_C 4.811506604588182e-07 / 0.027930843946287982 / 0.032681639982183666 0.0008756223675282764 / 0.0092856233481216 / 0.0015384650399147507
804 PPDPF_2 20_63522320_T_G / 20_63521771_A_C 5.287951236043515e-05 / 0.00689972604034751 0.043695255169413805 / 0.0005655672033991309
805 ITGA2_2 5_53091493_C_T / 5_53042183_A_C 5.4531358390517686e-05 / 0.03919199794742103 0.043791975990725485 / 0.0012604443318972665
806 SLC44A3_5 1_94839884_A_G / 1_94865029_A_C / 1_94857210_T_G / 1_94857357_C_G / 1_94892383_G_T 5.602338522082008e-05 / 0.046411065532556 / 0.007150508797521116 / 0.017457449518246654 / 0.009632517735858792 0.038972716080465035 / 0.008550555716824466 / 0.016460335501241437 / 0.008036938687219244 / 0.029740691948763408
807 USP4_5 3_49284594_T_A / 3_49305742_G_A / 3_49324936_C_T / 3_49335612_A_G / 3_49302213_T_A 5.782019897669962e-06 / 7.19205729889027e-06 / 1.709904241092868e-05 / 7.19205729889027e-06 / 5.51522445922424e-05 0.0014702427553570136 / 0.0018428609815186782 / 0.0024991863535684788 / 0.0018428609815186782 / 0.0003850173954240535
808 CCDC12_4 3_46922012_T_C / 3_46923707_C_G / 3_46941247_T_C / 3_46923591_T_G 5.914685515407129e-06 / 0.0018228664081414493 / 0.005309522612383735 / 0.004983454832882268 0.030142804350997518 / 0.03284103078371856 / 0.032410896819240385 / 0.04034475330385405
809 TRIOBP_4 22_37723206_G_A / 22_37734378_A_C / 22_37765828_T_TG / 22_37750578_C_T 5.971478816203375e-05 / 0.00027985715683595134 / 0.00029261375791339014 / 0.0030808446512811693 0.0051569691660451255 / 0.009407307485487609 / 0.022947122514129482 / 0.01009941891139795
810 RAF1_2 3_12603508_C_T / 3_12606048_T_TG 6.128646872671697e-07 / 0.0039523881023646075 0.0022616226810353037 / 8.653379217936721e-05
811 FMNL1_5 17_45241411_G_C / 17_45241412_C_G / 17_45243751_T_G / 17_45232440_T_G / 17_45244864_G_C 6.171874985510183e-05 / 0.00015929956646855425 / 0.003538404752618725 / 0.004784366369409091 / 3.9901595948387376e-05 0.0020906187745857413 / 0.0076474907511281205 / 0.013884774496511404 / 0.006430399709476225 / 0.0024365462048673877
812 RIPK4_2 21_41746606_T_G / 21_41746170_T_C 6.423837221659731e-05 / 0.00010177497615683857 0.014247426375762309 / 0.03297049438127817
813 AGPAT5_2 8_6724964_A_C / 8_6757085_A_G 6.429038885162565e-07 / 0.00364477408851887 1.266950151869815e-06 / 0.001321765776974001
814 USP48_3 1_21703696_T_C / 1_21706077_T_G / 1_21706735_G_A 6.450311033122228e-05 / 0.00028299304853152363 / 0.00012669514216415802 0.007845997236531468 / 0.01309954874203597 / 0.004449445235290158
815 AP1M1_8 19_16206608_T_TG / 19_16226612_T_C / 19_16227721_G_A / 19_16228258_G_A / 19_16228904_C_T / 19_16233717_C_G / 19_16234288_T_C / 19_16228794_T_G 6.528413032668653e-05 / 0.0064557081074910596 / 0.0024361725049911105 / 0.01837918810861549 / 0.025114292331133558 / 6.165054004198194e-05 / 0.002051667150159714 / 0.0008804072022582094 0.0008868669473225051 / 0.01491435109247843 / 0.00492438514382162 / 0.0030213758122107693 / 0.00454785100704076 / 6.396974124132157e-05 / 0.007302514064743812 / 0.008904488847639608
816 DAZAP1_2 19_1432575_T_C / 19_1432578_A_C 6.972933286419396e-09 / 0.00010616832462214354 0.008783799588482919 / 0.004625103934387489
817 PACSIN3_2 11_47180569_G_A / 11_47182508_A_C 7.134768403726839e-05 / 0.04020981298829434 0.021285924311691296 / 0.004000006496631303
818 R3HCC1_4 8_23288582_A_G / 8_23291465_G_T / 8_23293365_T_G / 8_23290051_G_A 7.2991599811489e-05 / 5.994421359171259e-05 / 0.012526023152146196 / 0.010041573920909331 0.02377854438814787 / 0.02377854438814787 / 9.39093538138813e-05 / 0.0033896878620269183
819 SERPINB5_10 18_63486810_T_C / 18_63487155_C_T / 18_63489373_G_C / 18_63493054_T_C / 18_63493152_T_C / 18_63503267_T_C / 18_63503488_T_C / 18_63503549_A_G / 18_63503234_G_A / 18_63504446_A_T 7.512909343200293e-07 / 1.61367941078967e-12 / 0.0017661748524282887 / 0.00358191163139034 / 1.15283914089761e-08 / 3.707481964958598e-05 / 3.699707858963291e-05 / 1.4974781606492456e-10 / 8.547425345240158e-05 / 0.001617719369677095 0.002310192116365421 / 0.0001900079796436893 / 0.0024982561142762962 / 0.004570527834506507 / 2.6119929305428517e-05 / 0.004811319593060203 / 0.00038813827261946135 / 0.0001894559075360232 / 0.008723212833525323 / 0.023248521588281557
820 U2AF1_2 21_43107500_A_C / 21_43107485_A_C 7.700487442691808e-05 / 0.0006563940756543221 3.5456060624197415e-05 / 0.0031649133811599275
821 LLGL2_4 17_75569181_T_A / 17_75558442_C_G / 17_75573695_C_CCT / 17_75575074_T_C 7.971949158890872e-06 / 3.785506483286314e-07 / 0.0064833437780985005 / 0.00395910816955325 0.018355040177942674 / 0.0004418073280201704 / 0.047670437975331784 / 0.004283559000108913
822 PPFIA1_4 11_70365468_A_G / 11_70375250_G_T / 11_70337631_C_G / 11_70331778_TCAAAAA_T 8.1777600824213e-05 / 2.2154751602898654e-10 / 0.007683460638024795 / 2.733195536548977e-07 0.01601938240153477 / 1.0104020665663723e-05 / 0.008528354106314544 / 0.002219921170959074
823 STAG3_2 7_100197862_A_C / 7_100182660_G_A 8.238419261021031e-05 / 0.008737491145039442 0.0017528283507844654 / 0.035261037489752685
824 MYO5B_13 18_49837561_G_C / 18_49875910_A_C / 18_49937217_A_G / 18_49954290_G_A / 18_49847096_G_A / 18_49849562_C_G / 18_49849733_C_G / 18_49880543_A_G / 18_49880568_T_C / 18_49929553_C_T / 18_49929610_GA_G / 18_49954528_T_C / 18_49962255_A_G 8.380774951798238e-06 / 0.006905476699523033 / 2.4263131433880795e-10 / 1.7494996128043332e-06 / 5.5387782704635815e-05 / 3.8985071268389133e-07 / 7.81858565470932e-07 / 1.54439656564615e-07 / 2.371423829111085e-08 / 8.182928222668989e-13 / 1.4176493799349745e-07 / 2.0981325041460703e-11 / 3.691444258026264e-11 0.03791686668587351 / 0.011592306302894794 / 0.0007689742137758647 / 0.011825548378506088 / 0.024802045476053625 / 0.0005688441791387698 / 0.0007265409595720793 / 0.010189243521059816 / 0.00680321425888459 / 7.83580041933832e-07 / 0.004868666362089778 / 9.442141848800156e-05 / 0.00020102188598339758
825 ZNF441_2 19_11767280_T_G / 19_11778532_C_T 8.6437303626739e-08 / 3.655373741478951e-07 0.00119501780413069 / 0.007941778018462287
826 FAM83H_3 8_143728128_T_G / 8_143725596_G_C / 8_143730455_T_G 9.215742981089235e-05 / 0.005987749784597274 / 0.0009621524329080232 0.005904909381665708 / 0.003207570177222234 / 0.011128551580065676
827 KCNAB2_4 1_6085319_C_T / 1_6095272_T_C / 1_6085347_G_A / 1_6094357_C_T 9.311243022811629e-05 / 0.0002214464879819671 / 0.007488052354416149 / 0.0004024482530986694 0.04271710391545418 / 0.04289813943359165 / 0.010697792728178102 / 0.030197643178852058
828 MMP15_4 16_58038249_C_T / 16_58042518_A_G / 16_58045261_G_A / 16_58037634_A_C 9.375120301838935e-05 / 1.005487978512005e-05 / 0.00013842386491697844 / 0.035127559966572304 0.006545735139458929 / 0.008269298799745639 / 0.016496855574598585 / 3.732680793190984e-05
829 PKNOX1_3 21_43028653_G_C / 21_43028665_G_A / 21_43029807_G_A 9.45086875135022e-05 / 9.45086875135022e-05 / 0.0028391505331848486 0.02993846952653303 / 0.02993846952653303 / 0.04630035756513505
830 CNOT6L_3 4_77720488_T_G / 4_77720486_A_G / 4_77726534_A_C 9.499774295611595e-07 / 0.0011515987198065605 / 1.5337206523072135e-05 0.00045440611666765506 / 0.003812687853894012 / 0.002323583718729919
831 C1orf109_4 1_37683521_C_T / 1_37689469_G_GGT / 1_37689593_G_C / 1_37684175_A_G 9.499906971175951e-07 / 3.357943291134777e-07 / 2.4786643546299445e-07 / 0.03129818295251388 0.0019238150218027989 / 0.005985910424044681 / 0.004025869106193675 / 0.0047335795687796075
832 MAP7_2 6_136361034_G_A / 6_136411526_G_A 9.631600220201912e-05 / 0.00020915694169969668 0.004233710215813943 / 0.03701019146859175
[표 18]에는 ERK_MAPK 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 18]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 40에는 [표 18]에 기재된 바이오마커들 중 주요 바이오마커들의 ERK_MAPK 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
ERK_MAPK 약물에 대한 반응성 바이오 마커 및 약물과의 반응성 검증 결과
No. FRH Variants(마커) Var_Drug(pval) Var_Exp(Pval)
1 INHBE_1 12_57456335_T_G 5.77E-14 0.023018015
2 SMAP1_1 6_70773272_G_A 1.18E-08 0.029985176
3 SPRY4_1 5_142319698_T_G 6.07E-08 0.000420223
4 THEM4_1 1_151909409_A_C 8.56E-08 0.035981352
5 SERPINB1_1 6_2837820_C_G 1.44E-07 0.008676416
6 EIF2B3_1 1_44926782_G_C 7.36E-06 0.00572911
7 DUSP6_1 12_89350540_G_A 8.18E-06 0.001102792
8 TOLLIP_1 11_1295591_A_C 1.13E-05 0.041990571
9 CDC5L_1 6_44387945_G_A 0.000100417 0.000850114
10 PAPD7_1 5_6746131_C_G 0.000186035 0.046879537
11 ABHD2_1 15_89199849_C_A 0.000373834 0.002565266
12 PLEKHM1_1 17_45436185_C_G 0.002692591 0.035787973
13 SMC6_1 2_17731999_A_C 0.003115924 0.045907596
14 RNF38_1 9_36400965_C_G 0.004214532 0.007012003
15 METTL16_1 17_2415256_G_C 0.007239539 0.043637945
16 PARP2_5 14_20351190_T_A / 14_20354336_G_T / 14_20344985_T_C / 14_20354983_A_C / 14_20354994_T_C 0.0003461397642250317 / 0.008144629651779057 / 1.6511185678613746e-06 / 9.423861936900617e-06 / 4.248961897732616e-05 0.0026213592391782425 / 0.0343587058197046 / 0.0388723494826529 / 0.009448771221863612 / 0.035110640891692815
17 CRYL1_6 13_20439533_A_G / 13_20439514_CA_C / 13_20404113_C_G / 13_20404176_A_C / 13_20489466_A_C / 13_20512438_C_G 0.0007457569282103447 / 0.04490288969730257 / 5.4112288097843236e-05 / 0.0004125161353078136 / 7.340308839823958e-10 / 0.0008144017559447111 0.02254568941445808 / 0.006925654927699 / 0.014412490268573512 / 0.0358490969666835 / 0.0036810252474824734 / 0.0005690585314639865
18 MBD2_2 18_54222304_G_C / 18_54224621_A_C 0.0009174927734817775 / 0.003370522943374522 0.041746449937120685 / 0.0024467066581282037
19 NUCKS1_3 1_205727543_G_A / 1_205720599_G_C / 1_205719615_A_C 0.0019226380117114328 / 5.15182042228384e-07 / 5.169743185885884e-06 0.007966391204853542 / 0.0020116543690140926 / 1.829062095579077e-05
20 TMEM8A_4 16_377516_T_C / 16_374277_G_A / 16_377010_C_T / 16_375326_T_G 0.0022458300017618115 / 0.0004991219763661549 / 0.008152821570691773 / 0.00033905970470333573 0.02280191742379471 / 0.008448241096869875 / 0.02464199505583077 / 0.03164430214292932
21 MCM8_5 20_5950428_T_C / 20_5954739_T_C / 20_5967525_G_A / 20_5963301_T_G / 20_5983067_T_G 0.002650766144390827 / 0.0020883309843753076 / 7.538671246466503e-12 / 0.0005138671174250025 / 0.00032159758644408336 0.02450503355623649 / 0.0030061115573713558 / 0.02006455848870967 / 0.0209284066776318 / 0.012878505995892143
22 COPS3_3 17_17280719_G_T / 17_17249049_GAA_G / 17_17280660_A_C 0.0027601645216709264 / 0.0055818454987667495 / 0.009754104106729505 0.019538058668087298 / 0.04875712280071096 / 0.02319033941785423
23 NEDD1_2 12_96937308_A_C / 12_96936634_A_G 0.004287874507177774 / 0.0016187072229015974 0.019399114812349873 / 0.02229964139566365
24 HDAC6_3 X_48803171_T_G / X_48817284_T_G / X_48817251_CAA_C 0.007173863496387051 / 0.0004972749557463768 / 0.0027277691674834114 0.008701773238861378 / 3.6233113107314475e-06 / 0.00929153924222002
25 MRPL39_6 21_25592759_G_A / 21_25601549_G_T / 21_25603910_C_T / 21_25603925_C_T / 21_25604009_G_A / 21_25599683_T_C 0.007753577611892022 / 0.0015571108862256187 / 0.005054758659783033 / 0.00740873550689033 / 0.005591788896050463 / 0.03750113388472616 0.033844596383331746 / 0.005711821633941189 / 0.043198910460816656 / 0.020407458243495952 / 0.026357543170222462 / 0.002961561939886723
26 ZBTB8OS_2 1_32621836_G_A / 1_32634036_A_G 0.010623328091650126 / 0.005807902867508034 0.00035085154745507385 / 0.001609648081432905
27 SNRPC_3 6_34767901_T_C / 6_34767875_CT_C / 6_34767875_C_CT 0.016258858934554518 / 0.0255807459946655 / 0.008409734593854818 0.0021977163744789038 / 0.005833052025345314 / 0.047890724740450176
28 SH3TC2_5 5_149010200_G_A / 5_149026823_T_C / 5_149040673_A_C / 5_149040676_A_C / 5_149004975_C_T 0.036452606469764885 / 7.993368579087101e-05 / 1.313354358475822e-12 / 1.6742742304793365e-07 / 3.0188094863269486e-08 0.005163368200425915 / 0.02459748424962984 / 0.04603790254373362 / 0.03254802106345967 / 0.01898788013634638
29 NUP188_7 9_128970680_G_T / 9_128981422_CT_C / 9_128999694_A_C / 9_128993243_C_G / 9_129003287_A_C / 9_128952722_CAAAA_C / 9_128981422_CTT_C 0.03889727834709586 / 5.679744903985549e-07 / 0.00015792708806478532 / 0.00011477857081826123 / 0.006528287639189813 / 1.3483326927899365e-05 / 0.001011406252669107 0.006235319995753044 / 0.0026090470755132837 / 0.04562376131737803 / 0.034372383646284414 / 0.006351306341421021 / 0.030396670064505107 / 0.0486576378436576
30 PDCD5_2 19_32581360_T_C / 19_32581212_C_G 1.0613555124907784e-06 / 0.01707686442489131 1.930613826710712e-05 / 0.00963168433129465
31 PCDH1_5 5_141865023_A_C / 5_141864261_A_C / 5_141864335_T_G / 5_141854096_T_G / 5_141864895_A_C 1.146087693284126e-13 / 2.954523514000492e-06 / 1.2399540998886776e-05 / 6.010776449757326e-05 / 1.3125365237964413e-06 0.00022379266342278662 / 0.0017861354200376558 / 0.02539846277902666 / 0.023845011173266668 / 0.014684779508972238
32 ARL6IP6_3 2_152718606_T_G / 2_152718941_T_G / 2_152718947_T_G 2.1444201135699293e-06 / 3.4179740940841686e-10 / 5.150737082224498e-05 1.916382486428584e-05 / 0.0014347496711839814 / 0.0018772601891545288
33 TPP1_3 11_6616021_T_G / 11_6619456_A_C / 11_6616207_T_G 3.898164047661344e-05 / 6.206193500590457e-06 / 7.13357999675385e-06 0.03721832122361987 / 0.0021180587349231865 / 0.022734527785541702
34 SLC35B2_2 6_44253096_A_C / 6_44255584_T_G 4.1264755521968e-08 / 2.206940612751773e-06 0.045514675788588387 / 0.0354190738183241
35 ETV5_6 3_186057145_T_G / 3_186057158_T_G / 3_186105591_G_A / 3_186064432_A_G / 3_186057367_T_G / 3_186057421_A_C 4.28224233645744e-14 / 2.8538105380699127e-12 / 3.537860306738235e-07 / 3.53456731728789e-05 / 8.933112160257351e-07 / 2.0618345030808515e-05 0.000899440048018852 / 5.426858809490545e-05 / 0.008678217049363252 / 0.012387170842740151 / 0.01078700094209001 / 0.04370939373064901
36 DUSP4_2 8_29340229_A_C / 8_29337473_A_C 4.4035389796360024e-07 / 0.0013351841168008725 0.01853773742959819 / 0.013684370845169195
37 ST3GAL4_3 11_126408340_T_G / 11_126406566_A_C / 11_126424657_A_G 4.582342844339244e-12 / 1.1939071093750443e-06 / 6.212889562458534e-09 7.802484819683297e-05 / 0.006286854884921811 / 0.03738872157996522
38 SKP2_3 5_36183922_T_C / 5_36168236_A_G / 5_36168246_T_G 4.974059042110084e-09 / 2.3219549423702208e-12 / 1.6076332463417848e-08 0.008092624659189506 / 0.01597032245832584 / 0.022784487945753537
39 GPBP1_3 5_57230956_G_A / 5_57231420_T_C / 5_57251232_G_A 4.99115882517327e-06 / 1.8819931578981247e-06 / 2.491196233571318e-05 0.038048986044057084 / 0.04556667822911722 / 0.018325268985280727
40 CMTM7_2 3_32441841_T_G / 3_32454197_C_G 5.20316947282785e-11 / 1.865488768400554e-06 0.022587609002975642 / 0.027278626571090647
41 LRP5_2 11_68429633_T_G / 11_68448944_A_C 8.179359573414423e-10 / 2.733681134387847e-06 0.01579807768279053 / 0.024681714140317668
42 ETV4_2 17_43544973_A_C / 17_43533230_T_G 8.216801793356959e-07 / 9.218453009083366e-06 0.025227174262734704 / 0.0007956602344066278
[표 19]에는 IGFR 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 19]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 41에는 [표 19]에 기재된 바이오마커들 중 주요 바이오마커들의 IGFR 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
IGFR 약물에 대한 반응성 바이오 마커 및 약물과의 반응성 검증 결과
No. FRH Variants(마커) Var_Drug(pval) Var_Exp(Pval)
1 SEPT6_1 X_119618658_T_G 1.08E-09 0.00240717
2 EPHA2_1 1_16148437_A_C 2.39E-08 0.003022958
3 VRK1_1 14_96853031_T_G 3.01E-06 0.034233405
4 ACTR3_1 2_113934245_G_T 4.92E-06 0.01245207
5 FOS_1 14_75280999_A_C 6.24E-06 0.001488063
6 FCHO2_1 5_73082876_ATT_A 1.08E-05 0.029256929
7 RAC1_1 7_6401802_T_G 2.22E-05 0.003141263
8 CXCR5_1 11_118886492_C_G 6.30E-05 0.044645013
9 KCNQ5_1 6_72622312_C_G 8.39E-05 0.005821769
10 ACSS2_1 20_34920910_T_G 8.92E-05 0.038456731
11 CRLF3_1 17_30792416_T_G 0.000107788 0.014789711
12 TSEN34_1 19_54192354_T_G 0.000113175 0.001848481
13 GTF2IRD1_1 7_74512993_A_G 0.000122837 0.006481631
14 CECR1_1 22_17188516_G_C 0.000127223 0.003052868
15 MAP4K1_1 19_38617327_T_G 0.000134054 0.013203631
16 PAPSS2_1 10_87727355_T_G 0.000165034 0.012652487
17 LAMC1_1 1_183131172_CAA_C 0.000221332 0.002417084
18 TBX21_1 17_47742656_A_C 0.000232988 0.004538883
19 PNRC2_1 1_23961703_G_C 0.000287734 0.015853081
20 HSPG2_1 1_21885485_A_C 0.00029294 0.028105373
21 CD72_1 9_35610848_A_C 0.000296281 0.049937736
22 KLF3_1 4_38689006_A_C 0.000348148 0.015121455
23 ZNRF3_1 22_29048501_A_C 0.000348188 0.024970519
24 ASAP2_1 2_9399979_T_G 0.000416146 0.021780475
25 CCDC69_1 5_151185396_T_C 0.000422551 0.005439839
26 EPS15_1 1_51472751_T_G 0.000562256 0.00454227
27 CBR1_1 21_36071267_G_C 0.000703843 0.005777456
28 CST3_1 20_23634133_A_C 0.000813367 0.047435887
29 IGF1R_1 15_98934682_T_G 0.00081535 0.004668174
30 MEI1_1 22_41699656_A_C 0.000847426 0.019192604
31 PTPN6_1 12_6946697_T_C 0.000924277 0.002400753
32 PMEPA1_1 20_57700062_A_G 0.000939285 0.036764657
33 WASL_1 7_123692324_GA_G 0.001014849 0.000396379
34 ARHGAP15_1 2_143228433_T_C 0.001096444 0.039221572
35 CLDN12_1 7_90413108_T_G 0.00113931 0.004520847
36 UACA_1 15_70669470_GA_G 0.001211403 0.03571568
37 TRIM2_1 4_153276097_A_G 0.001260338 0.011894098
38 RCC2_1 1_17413487_C_A 0.001306044 0.02349276
39 CD48_1 1_160711863_GA_G 0.001708644 0.04718285
40 GLCE_1 15_69261053_A_G 0.001722968 0.004293961
41 C21orf91_1 21_17793434_T_G 0.001758128 0.044828498
42 SIGLEC10_1 19_51417063_T_G 0.00177184 0.045299996
43 NCKAP1_1 2_182967372_CA_C 0.001831659 0.004822611
44 CD86_1 3_122103557_A_C 0.001895858 0.046671667
45 ERRFI1_1 1_8013331_A_G 0.001920351 0.000188249
46 PTPRC_1 1_198703381_A_C 0.001955402 0.027037687
47 CTDSPL_1 3_37957127_T_G 0.002306486 0.04933152
48 TAF4B_1 18_26286027_C_A 0.00252716 0.005234164
49 CDC42BPB_1 14_102939620_T_G 0.002756257 4.78E-05
50 CTBP2_1 10_125026073_A_G 0.002878802 0.03391949
51 RASAL3_1 19_15458567_G_C 0.003342618 0.038134018
52 HLA-DOB_1 6_32813293_A_C 0.003408106 0.048853006
53 WAS_1 X_48691219_A_C 0.00381355 0.02612273
54 HBS1L_1 6_134965300_CA_C 0.004012929 0.010966837
55 FCRL5_1 1_157518564_T_C 0.004367637 0.023539142
56 UHRF2_1 9_6482002_G_T 0.004387102 0.007025127
57 SPR_1 2_72891611_A_C 0.005381455 0.000101783
58 DHX32_1 10_125867071_T_C 0.006025442 0.015306739
59 DAG1_1 3_49531399_T_G 0.006122816 0.000829773
60 RAVER2_1 1_64768580_T_G 0.007604338 0.049067483
61 KIAA0922_1 4_153635457_C_T 0.007681106 0.042172485
62 ITGAV_1 2_186637080_T_G 0.0079744 0.00113911
63 MSL3_1 X_11772199_A_C 0.00797531 0.040182738
64 LAPTM5_1 1_30733959_T_C 0.008095451 0.005337526
65 TPBG_1 6_82364929_T_C 0.009219323 0.003828919
66 CD52_1 1_26320120_TAA_T 0.009857578 0.041028395
67 APOBEC3G_1 22_39086265_G_T 0.009915615 0.042244805
68 ZNF107_1 7_64708051_G_A 0.010400777 0.013846694
69 PALLD_1 4_168691310_GT_G 0.011706523 0.009714355
70 WTAP_1 6_159753424_T_G 0.01384856 0.00215073
71 HCLS1_1 3_121634273_T_G 0.019280657 2.45E-06
72 AVPI1_1 10_97677649_A_G 0.021081758 0.001581419
73 FAM129B_1 9_127578987_C_T 0.021421759 0.016089528
74 SH3RF1_1 4_169096709_G_A 0.024084182 0.008799276
75 DR1_1 1_93361899_T_A 0.025156433 4.48E-05
76 CTTNBP2NL_1 1_112457049_C_A 0.028077079 0.00620874
77 PPP3CC_1 8_22539268_TC_T 0.032546359 0.004572653
78 WIPF1_1 2_174585550_T_G 0.037854213 0.000483959
79 RNGTT_1 6_88769645_C_T 0.04013553 0.002545266
80 CUEDC1_1 17_57873465_G_A 0.046175827 0.009658282
81 TMEM106A_2 17_43216747_A_C / 17_43216763_T_C 0.00010599595448116978 / 0.0011257303404920308 0.0005249300563644175 / 0.0005036765332449491
82 ARHGAP9_2 12_57474996_G_A / 12_57474460_G_A 0.00010627135291362362 / 0.0006872861852919692 0.036897912823510064 / 0.04135748735535435
83 ARHGAP25_3 2_68775067_A_G / 2_68818005_T_G / 2_68818023_T_G 0.00011953760418312583 / 1.4150706205617486e-06 / 0.0059084060389890105 0.04538887525617117 / 0.0040433016624282225 / 0.00032630206809361283
84 LMNA_2 1_156134461_T_G / 1_156139242_AT_A 0.00013744315797654898 / 0.021258069595818274 0.029742625031540286 / 0.04237931129547261
85 DAGLA_2 11_61734985_A_C / 11_61728297_A_C 0.00016688573126791192 / 8.09952511657234e-05 0.004132304336839055 / 0.025660366426589504
86 NR2F6_2 19_17240636_T_G / 19_17232479_A_C 0.0002005112664246795 / 0.004658617789678825 0.0007905076911971658 / 0.04560309985715085
87 PLEKHA1_2 10_122406608_C_A / 10_122426897_T_G 0.0002168843436880945 / 0.005333013480801039 0.013835632948640248 / 0.02718721223708819
88 APP_2 21_25881669_T_G / 21_25881706_A_T 0.00025836883792981226 / 0.012490170798802495 0.0009005203285702301 / 0.007363278374314075
89 ATP1B1_2 1_169127312_A_G / 1_169131404_A_C 0.0002769045008439269 / 0.0004647954716516378 0.009381431280957959 / 0.04764456683437238
90 IL10RA_2 11_117999603_A_C / 11_117999569_T_G 0.0003635149788055047 / 0.002791509228208489 0.033136103226175016 / 0.042909053419655285
91 ERICH1_7 8_658279_A_G / 8_659132_C_G / 8_659777_T_G / 8_666991_A_G / 8_673593_G_A / 8_659879_A_C / 8_664843_G_C 0.00036987702944603015 / 5.389836081615414e-05 / 0.042347501906470714 / 0.03423827293146818 / 0.002457155038695027 / 0.005217531740497581 / 0.03193881349739397 0.004174871941240723 / 0.0054140514901705895 / 0.007294372779032101 / 0.0012649483439199085 / 0.01865482112843118 / 0.0461414202945825 / 0.005281332497371782
92 ITGB5_4 3_124769064_T_G / 3_124809087_T_G / 3_124817591_T_G / 3_124859372_A_C 0.0004279586059829587 / 0.0005503781084358106 / 2.8998064871450438e-05 / 0.007293322508081707 0.0006588536356118503 / 5.4585187494895796e-05 / 0.004666117329251896 / 6.144253538463827e-06
93 RFTN1_4 3_16357670_G_A / 3_16369972_C_G / 3_16433938_A_G / 3_16316966_A_C 0.0005124144917873522 / 0.0007740692582134723 / 0.02739900235302105 / 1.3310696006188425e-05 0.014764917085914387 / 4.009218111239421e-08 / 9.30606513108498e-07 / 0.008243705342181723
94 RBFOX2_4 22_35759903_A_G / 22_35746471_A_C / 22_35761128_GA_G / 22_35745982_A_C 0.0005772251529531363 / 0.0026032665751075587 / 0.0005990432899641425 / 0.00370365047461572 0.0021501446732444386 / 0.003606660377686972 / 0.04845122900481105 / 0.009865449869643949
95 VSIG10_3 12_118095590_T_G / 12_118073908_T_G / 12_118095640_G_C 0.0006180518934147943 / 0.000288504312752602 / 0.003668316042902092 0.013058144491121623 / 0.0019761216603789984 / 0.03443934455659579
96 PLEKHG3_2 14_64741663_T_G / 14_64743474_T_G 0.0007814263254356411 / 0.001157048611523175 5.022222887595109e-05 / 0.0004341351157000161
97 ATP11A_7 13_112832759_A_G / 13_112871823_T_C / 13_112860417_A_C / 13_112810736_A_C / 13_112856140_A_C / 13_112832768_A_C / 13_112860332_A_C 0.0007951918344761818 / 0.0005482830943215422 / 0.0008173410245384687 / 0.00028609539850556404 / 0.0005652380914145368 / 0.01755140978606275 / 0.0026211055327575693 0.03593739412008719 / 0.030074291108272512 / 0.013638179892540932 / 0.02325523862538697 / 0.008605914805152383 / 0.0022773790348338983 / 0.006067631423556552
98 RUNX3_2 1_24907301_T_G / 1_24907326_T_G 0.0008468237773895464 / 0.006925491973632575 0.0479402881785652 / 0.03367486268556343
99 CTTN_3 11_70419876_A_C / 11_70419880_T_C / 11_70407283_C_T 0.000966697322875658 / 3.5345921815367516e-05 / 0.005641133258474765 0.00030309409522359497 / 0.003131141961303907 / 0.005941149857145408
100 CCDC28A_2 6_138785343_A_C / 6_138792859_T_C 0.0013622718680866052 / 0.005185054082793079 0.011499421256994664 / 0.046299906365056015
101 CD63_3 12_55725557_A_C / 12_55725568_A_C / 12_55727027_A_C 0.0015370519252913715 / 4.143328592583745e-05 / 0.0004442658715243917 0.006833645667760305 / 0.006277176385590093 / 0.0005016030317793939
102 SCARB2_2 4_76179751_A_C / 4_76179754_T_C 0.0016868597515864868 / 0.0015619118205883007 0.009508010711643462 / 0.003674712454161551
103 TJP1_4 15_29737354_A_C / 15_29761137_A_C / 15_29761418_A_C / 15_29718609_T_G 0.001722668303128766 / 0.001802650233952311 / 0.0039948883415691075 / 0.0004981143114140755 0.03635480241931981 / 0.005695684405240236 / 0.0032087876676378537 / 0.035918560945748516
104 CD84_2 1_160549875_A_G / 1_160550877_C_G 0.0018095916002787247 / 0.0007689474612337844 0.011914227680681896 / 0.04088607952168802
105 IKZF1_3 7_50368194_A_C / 7_50382645_A_C / 7_50387420_G_C 0.0018105241430139086 / 0.014707321465940356 / 0.001698752501804824 0.008403541889994377 / 0.009343110426337882 / 0.005840601801883746
106 LCP1_3 13_46143111_T_C / 13_46143326_T_G / 13_46143333_A_T 0.0018838737568387656 / 0.0030138622548272647 / 0.002533014213361492 0.004087453394348643 / 0.0014213406956657436 / 0.005160539969200112
107 FAM177A1_2 14_35081207_T_C / 14_35081218_T_C 0.0021562993680550448 / 0.0011900365723686852 0.020934419309292008 / 0.02682119468565008
108 WDR91_2 7_135211631_T_C / 7_135187272_A_C 0.0024692334154964657 / 0.032950442555311085 5.806021129546451e-05 / 0.006217596359933296
109 KLHL6_3 3_183492078_A_C / 3_183508233_G_T / 3_183508495_A_C 0.0026331756981726236 / 0.022647868110278375 / 7.774725762863598e-05 0.03828309904439229 / 0.005722620392157443 / 0.025101287121564474
110 ZNF543_2 19_57329179_A_G / 19_57328339_A_C 0.002905904571144909 / 0.0017155256244295665 0.0030296713890405878 / 0.0008395371531401164
111 PLEK_6 2_68380987_A_C / 2_68380990_A_C / 2_68386526_T_G / 2_68388306_A_G / 2_68388311_A_G / 2_68395610_G_T 0.0029347945425916644 / 0.002463266314490245 / 0.0008850637706738338 / 9.333617954680645e-06 / 0.0006950651263355477 / 0.0073361864658662125 0.0018651167043750433 / 0.004434568689990568 / 0.0232360676072928 / 0.012112306050675708 / 0.028732570109628937 / 0.04207168924285536
112 KDM4C_2 9_6990364_G_T / 9_7103596_C_T 0.0029959320396048127 / 0.031190087077651845 0.01165227785409256 / 0.0003043755324224803
113 STAG3_6 7_100197862_A_C / 7_100197337_A_T / 7_100197348_T_C / 7_100201126_G_C / 7_100180467_A_G / 7_100202616_A_T 0.003032352954227882 / 0.0003006428065929603 / 0.0015227072304436168 / 7.395320763427399e-05 / 2.7805601294277643e-05 / 0.0008727651283899594 0.0017528283507844654 / 0.0366941229125814 / 0.023320205307304158 / 0.027602097077102532 / 0.04660308396540184 / 0.020109594472644786
114 WDFY4_2 10_48733932_A_G / 10_48709976_C_T 0.00343399726598083 / 0.014958425459696244 0.04160917875360734 / 0.036092320181802036
115 PEX3_2 6_143462894_AT_A / 6_143468044_A_T 0.0038068988591272368 / 0.004816984657632503 0.01772831437707046 / 0.001265609891969809
116 FERMT3_2 11_64207498_T_G / 11_64220073_T_G 0.004734854868796705 / 0.0003860702269228193 6.601869405274685e-06 / 0.034308160983635066
117 ARHGAP5_3 14_32092970_T_C / 14_32154828_T_C / 14_32092963_G_C 0.00497062236861118 / 0.0024371349542205195 / 0.03352695059876293 0.000109609141495362 / 0.0028505632724505807 / 0.007275592799482284
118 NGLY1_3 3_25733762_T_C / 3_25736073_G_T / 3_25732334_A_C 0.0050051985544428655 / 0.00013354579539043645 / 0.00040433124284776166 0.0004571643127465467 / 0.0001003348545752524 / 0.0008517116761761035
119 NCKAP1L_3 12_54532103_A_T / 12_54509948_A_C / 12_54542688_G_C 0.005115130095563281 / 0.006142923665719964 / 0.003395761947631717 0.006178462220094093 / 0.01506335399115959 / 0.04657402586559346
120 DCK_2 4_71023692_C_A / 4_71022615_CTT_C 0.00551147320732032 / 0.003204858946259472 0.03456399228988244 / 0.04731976901534782
121 CNOT10_2 3_32705030_A_G / 3_32717271_G_A 0.005986207049477181 / 0.010027593265925021 0.0007110070373588129 / 0.0032142136890770555
122 ZNF430_2 19_21033730_G_A / 19_21022773_T_G 0.0060011071152059935 / 0.001269711279469131 3.875366882434858e-05 / 0.024171318376603662
123 DIRC2_2 3_122795117_A_C / 3_122856322_A_G 0.006254194164645703 / 0.003207873756680403 0.006533610459085206 / 0.013416690563532
124 DENND1C_2 19_6469618_A_C / 19_6466439_T_G 0.0067186287718049645 / 0.0016600261620732227 0.03949757317188018 / 0.022653353998851232
125 MRPL39_3 21_25592788_C_A / 21_25601549_G_T / 21_25599683_T_C 0.007244177399862964 / 0.02581153853071456 / 0.006446955687932745 0.0040263096113157286 / 0.005711821633941189 / 0.002961561939886723
126 POLH_2 6_43587207_T_G / 6_43587205_A_G 0.007282790737761695 / 0.004119102235979657 0.002197498680435875 / 0.0001905626583652103
127 LTBP3_4 11_65547976_T_G / 11_65547974_A_G / 11_65541348_A_C / 11_65543270_A_C 0.008230993013661442 / 0.002905381602762654 / 3.41563836791927e-05 / 0.000404704876316852 0.0010020580443514707 / 0.013780067605462305 / 0.02423580877660449 / 0.030868539513201374
128 CCND1_2 11_69650913_A_G / 11_69643258_A_C 0.009099246706999426 / 0.0062885656582625715 0.024298615321604846 / 0.0008578909246964013
129 CTNNA1_4 5_138812304_T_G / 5_138933920_C_T / 5_138932696_A_G / 5_138812295_G_A 0.009367597372283164 / 6.3503870330673816e-06 / 0.025253708380473885 / 0.0007665667912501635 0.013339032203366944 / 0.00010488952235634391 / 0.007557173168109447 / 0.014548265287747147
130 WDR7_2 18_56679573_T_G / 18_56781547_G_A 0.00936770621562205 / 0.0029337854053434692 1.7583606026050092e-08 / 0.0071713352600959014
131 RCL1_5 9_4844704_T_C / 9_4844778_A_C / 9_4849647_T_C / 9_4860917_G_GT / 9_4860980_G_A 0.01015934986765833 / 0.008166765063815772 / 0.013723578341305795 / 0.006228375621470136 / 0.0009546809601140933 0.001687161016128972 / 0.0053342789487147045 / 0.004306767506877943 / 1.3652309819438526e-05 / 0.014590769537426704
132 ZCCHC14_5 16_87414470_A_C / 16_87411666_T_C / 16_87412604_T_G / 16_87412609_T_G / 16_87407905_T_G 0.01093006007749231 / 0.004904074942282202 / 0.0043682847900583565 / 0.00032200703750807235 / 0.00016922609654741882 0.007871655864135534 / 0.012673355773035487 / 0.00292819630706063 / 0.0093411624607831 / 0.04674575207321762
133 TOM1L1_3 17_54937096_G_T / 17_54937101_G_T / 17_54947274_A_C 0.011389249245863157 / 0.02378503173158879 / 6.37493870407225e-05 0.0005351253630963304 / 4.7382046214109506e-05 / 0.0003719570020930906
134 SVIL_2 10_29532000_A_C / 10_29486218_G_T 0.014203541816552456 / 3.6685991514458535e-06 0.005199248570547408 / 0.02127330473082788
135 TEAD4_2 12_3019250_C_T / 12_3022032_A_C 0.02289390603064881 / 0.0001066489771189534 0.0016254072731388984 / 0.0001892435681560084
136 ARHGAP30_2 1_161052161_T_G / 1_161069551_T_G 0.026797750313656932 / 0.0002673414213531623 0.0011705834898046734 / 0.030642225735204174
137 FMNL1_3 17_45232440_T_G / 17_45238511_T_G / 17_45238503_C_G 0.02756877460315332 / 0.0011473580213809565 / 0.0021134470829949274 0.006430399709476225 / 1.3130360508344227e-05 / 0.014111760701313713
138 CD151_3 11_836023_C_T / 11_836227_A_G / 11_835877_C_T 0.031310628277621426 / 0.01189492161114428 / 0.0465236859230004 0.004311678571283407 / 0.001633994415617101 / 0.005759250847020773
139 MBD2_2 18_54204938_G_A / 18_54224621_A_C 0.032527518290623295 / 0.02387217907579878 0.007481293790069707 / 0.0024467066581282037
140 ACAP1_2 17_7350305_C_T / 17_7343627_T_G 0.03440244080220003 / 9.989468867792128e-05 0.009955377908509965 / 0.02484432576482206
141 RHPN2_4 19_33002924_G_A / 19_33044231_A_G / 19_33044540_A_C / 19_33011638_C_G 0.03758598191114063 / 6.498164345874758e-05 / 0.0019234652198936038 / 0.0005607094271426628 0.001694407500706198 / 0.0003445437417821702 / 0.0007353894363862997 / 0.0002119158667786005
142 RASSF2_3 20_4797919_T_G / 20_4784304_T_C / 20_4784247_T_G 0.037902749156553485 / 0.011694257494444695 / 0.00032929741865870437 0.007153311060028534 / 0.0020239510039769416 / 0.0013542591543729706
143 MYO1G_4 7_44965836_A_C / 7_44970706_A_C / 7_44964431_G_T / 7_44979051_A_C 0.04191223689634028 / 0.01979144289427551 / 0.00017645318680118606 / 0.041733273291402466 0.007221347246269528 / 0.002699507313002306 / 0.005180419499391653 / 0.0010403929060933288
144 PIK3CD_4 1_9720778_T_G / 1_9720785_A_G / 1_9719895_T_G / 1_9718938_A_G 1.0253516427976307e-05 / 0.0046476512085552105 / 0.00011802831952668278 / 0.006759908616419049 0.0012148539768169404 / 0.0398063487615097 / 0.0044497374818740715 / 0.04703097613769788
145 PTGR1_2 9_111594107_A_G / 9_111578959_GAA_G 1.5065359948490627e-06 / 0.005936401163136037 0.00764869645742515 / 0.03809849817293055
146 SH3D19_3 4_151122202_T_C / 4_151148202_G_T / 4_151175208_T_G 2.2029420860104835e-05 / 0.0016057485146252267 / 0.0049299501495510155 0.00026537095134489047 / 0.004030165987762314 / 0.036616308047703286
147 DTNBP1_2 6_15662698_A_G / 6_15662701_T_G 2.9366152452741533e-06 / 0.0006517798782510246 0.0063060334020981846 / 0.001004314451212422
148 ZNRD1_3 6_30062280_G_A / 6_30062358_G_A / 6_30062412_T_A 3.654974597084793e-05 / 1.1618445697892011e-05 / 0.0003334426304369216 0.006713962039550535 / 0.011500969330972352 / 0.02821821301850212
149 SPATS2L_7 2_200329386_C_A / 2_200412288_CT_C / 2_200329511_A_C / 2_200412421_T_G / 2_200412425_T_G / 2_200477943_T_G / 2_200473083_GAA_G 4.207550681496029e-05 / 0.0004415561732387749 / 2.0249110903712733e-05 / 6.324482115669083e-05 / 0.00042055460201680485 / 1.4403669192542887e-05 / 0.007061797305907755 0.0033487592228469143 / 0.011019446375268936 / 0.02491924164389806 / 0.03547678698863923 / 0.024316311222524558 / 0.016080388811817628 / 0.0009052273948575811
150 ELOVL5_4 6_53295600_A_G / 6_53295602_T_G / 6_53291875_T_C / 6_53291854_T_G 4.333948606334787e-05 / 9.154580881914281e-06 / 0.002303807174924029 / 0.010895023484809672 0.0008036056664569972 / 0.0007993551420952537 / 0.0030362229822457412 / 0.005396507263205953
151 AGER_6 6_32183680_C_G / 6_32183336_A_C / 6_32180626_G_C / 6_32182537_A_C / 6_32182532_A_C / 6_32180983_T_G 4.3474785520824183e-07 / 0.0008401867950240421 / 0.00012577188862559035 / 7.864018103130946e-05 / 0.0001383347487645318 / 0.0006412069737516832 0.026487158302874552 / 0.0008365781303084246 / 0.018710849801424196 / 0.024237923466307005 / 0.005092878554310726 / 0.028565251544064637
152 KLHL18_3 3_47319581_T_G / 3_47344095_C_A / 3_47319585_T_G 5.8893512793953086e-05 / 0.003560559459732024 / 0.0014314792247920815 0.013218876001835087 / 0.0063137500959640856 / 0.0442868915202707
153 RBM6_6 3_50054242_G_T / 3_50054246_C_T / 3_50054250_C_T / 3_50054257_G_T / 3_50054263_T_G / 3_50066429_G_T 9.610797412978416e-06 / 0.0004692267600390496 / 0.001169115137001947 / 0.016014825049119413 / 0.00038946159538077817 / 6.545113568163317e-06 0.0124136469122058 / 0.0004024483543288937 / 3.272618868931358e-05 / 5.8729619078742086e-05 / 0.00033057063887385755 / 0.0016854676901857401
[표 20]에는 MITOSIS 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 20]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 42에는 [표 20]에 기재된 바이오마커들 중 주요 바이오마커들의 MITOSIS 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
MITOSIS 약물에 대한 반응성 바이오 마커 및 약물과의 반응성 검증 결과
No. FRH Variants(마커) Var_Drug(pval) Var_Exp(Pval)
1 CYR61_1 1_85581605_TA_T 5.27E-05 0.000620768
2 MYB_1 6_135201764_A_C 0.000110474 0.008038119
3 MYH9_1 22_36302635_A_C 0.000236116 0.040823397
4 SNX24_1 5_123023772_TA_T 0.00028033 0.010215104
5 CHAF1A_1 19_4442532_T_C 0.000284751 0.010330163
6 CASP8AP2_1 6_89846678_CT_C 0.000313931 0.000126501
7 MTF2_1 1_93137118_TA_T 0.000462823 0.036903175
8 EGFR_1 7_55170771_T_G 0.000668389 0.004588325
9 ACVR1_1 2_157799371_CA_C 0.000905558 0.016548442
10 MED12_1 X_71132797_T_C 0.000941588 0.024279673
11 TRA2B_1 3_185921167_T_C 0.001087771 0.003158761
12 CYB5R3_1 22_42619486_G_T 0.001094814 0.002582708
13 NFX1_1 9_33303208_A_G 0.001100893 0.023431449
14 UACA_1 15_70669470_GA_G 0.001412253 0.03571568
15 MOK_1 14_102304907_T_C 0.001776612 0.001629205
16 RNF138_1 18_32123591_T_C 0.001798779 0.018606829
17 NMT2_1 10_15119275_A_C 0.002227268 0.015194231
18 DLG2_1 11_83980458_A_G 0.002667354 0.014824348
19 RIN2_1 20_19990244_G_A 0.002695061 0.013004393
20 DHX15_1 4_24540080_CT_C 0.003782084 0.012007783
21 CD276_1 15_73702902_T_G 0.00386155 0.020273648
22 HDAC2_1 6_113944423_T_C 0.004344928 0.041935697
23 PIAS4_1 19_4039058_G_C 0.005375712 0.037776153
24 ARHGAP15_1 2_143216291_G_A 0.005719356 0.035966273
25 STRBP_1 9_123266116_C_G 0.006459968 0.001078377
26 MYO1C_1 17_1484178_C_T 0.007569353 0.007802374
27 EPB41_1 1_29015578_GA_G 0.007616579 0.046541231
28 PRDM2_1 1_13823349_T_A 0.00796288 0.011003429
29 MDM4_1 1_204536848_GA_G 0.008010095 0.021420681
30 C1R_1 12_7091679_A_C 0.00873535 0.0246229
31 RGS16_1 1_182600365_T_G 0.009039587 0.036240935
32 KIFC3_1 16_57765532_T_G 0.009062011 0.038497261
33 NOTCH2_1 1_119922384_T_A 0.009876287 0.022769433
34 PRPF38A_1 1_52416794_T_G 0.012365097 0.004382879
35 U2AF1_1 21_43093000_GT_G 0.018718881 0.003527509
36 FNDC3B_1 3_172328905_GT_G 0.019450759 1.78E-05
37 ITPRIPL1_1 2_96325641_T_G 0.024457637 0.004828474
38 PRKCB_1 16_24174494_CT_C 0.029704271 0.000670802
39 GMEB1_1 1_28702335_T_A 0.031116839 0.003887013
40 IL6ST_1 5_55960635_CT_C 0.045023867 0.00567988
41 SRGAP1_1 12_64142411_T_C 0.046097342 0.006505853
42 DNMT1_1 19_10162649_G_A 0.048749303 0.001347433
43 NPC1_2 18_23540944_CT_C / 18_23539283_G_A 0.00011218638512848764 / 6.166244499849825e-05 0.040822963170832685 / 0.020956228007299703
44 KDM2B_2 12_121579943_C_CA / 12_121534367_T_A 0.0002469480356989407 / 0.00024928370737718086 0.01794421156168876 / 0.01671856514998881
45 MET_3 7_116740945_T_G / 7_116757685_T_G / 7_116795676_T_G 0.00037055097855276256 / 0.003772251227706767 / 0.04454843008676103 0.00017295700570667475 / 5.0554093231126755e-05 / 0.0006156874780574698
46 WWTR1_2 3_149669685_C_T / 3_149669894_G_A 0.0006147608436462098 / 0.0050779807840600905 0.040303211258058205 / 0.014886977556994025
47 RPRD2_2 1_150470594_A_C / 1_150473591_C_T 0.0006254084658607492 / 0.029513176305296374 0.04999439760188915 / 0.008299610316019734
48 PHIP_9 6_78946845_A_T / 6_78965984_A_G / 6_78947674_G_A / 6_78954723_T_C / 6_78955493_T_A / 6_78969860_A_G / 6_78985312_C_T / 6_78998206_C_T / 6_79043075_T_C 0.0007025290839441325 / 0.0008446291153155781 / 0.010121938819521418 / 0.017201835088518632 / 0.014930588444064525 / 0.02454094082336056 / 0.009915783788926756 / 0.0023583595976247713 / 0.011026610846676282 0.0325055100647953 / 0.0325055100647953 / 0.0010048550446085317 / 0.00648756713202656 / 0.009594339103514994 / 0.0017203137452171692 / 0.0007527047164367361 / 0.006763071535609179 / 0.0016364259457283912
49 USP37_2 2_218485635_CAAAA_C / 2_218455538_T_G 0.0008931966771009113 / 0.00047307780771944745 0.04869664909579453 / 0.006248282014078397
50 RRAS_3 19_49636811_C_T / 19_49636835_G_A / 19_49636989_C_A 0.0012180086241795427 / 0.0008453114718541902 / 0.00389443225116509 0.011066495702872568 / 0.008806050890865063 / 0.010977696307794636
51 SHPRH_7 6_145910334_C_A / 6_145922445_C_T / 6_145923607_A_G / 6_145947487_T_A / 6_145948270_A_C / 6_145955343_T_G / 6_145922945_GT_G 0.0015751671472739686 / 0.008305307007300559 / 0.003356044877090312 / 0.00413644978183887 / 0.009574107378650136 / 0.0002467850170635296 / 0.0028322412885894953 0.0007641881109242402 / 0.0008695206428685066 / 0.0004025103622500861 / 0.0002754715942379004 / 0.020534325332750382 / 0.0019437040989644704 / 0.0032085441168495693
52 LAMB2_2 3_49132472_A_C / 3_49126013_T_G 0.0017423458459882547 / 0.041025181157896495 0.0019625130257961386 / 0.002569958840604656
53 THRAP3_2 1_36288866_G_C / 1_36282396_ATTT_A 0.0020512788997300887 / 0.0016248690625818355 0.0001317384338547229 / 0.04220913139330165
54 CTNNA1_2 5_138932696_A_G / 5_138932714_T_G 0.002692413567981528 / 0.005472909098268261 0.007557173168109447 / 0.0016091365079487266
55 TAPT1_2 4_16162866_G_A / 4_16202603_GA_G 0.002918386893883101 / 0.000914379509289869 0.000763966557961968 / 0.0004886648390188492
56 SLC35F5_3 2_113717856_GA_G / 2_113742699_CA_C / 2_113723196_TA_T 0.003014076668232333 / 0.005012402765669162 / 0.0170410099009839 0.01701812431912492 / 6.159712513106605e-06 / 0.009792441988171948
57 CCAR1_3 10_68737016_C_A / 10_68747145_CT_C / 10_68760969_CT_C 0.00325467857819848 / 0.025692165325181263 / 0.0016743825966123902 0.003954046326130957 / 0.007417608363424872 / 0.007417608363424872
58 TADA1_2 1_166858437_T_C / 1_166869276_TA_T 0.003257661220538658 / 0.007643004397209361 0.012600985482671512 / 0.00358370659710894
59 SAFB_2 19_5668433_GT_G / 19_5653276_T_G 0.0039066263073592 / 0.0014480393694902619 0.0026106809691974946 / 0.018733735357902476
60 LEPROTL1_2 8_30105682_AT_A / 8_30156243_A_C 0.005708636597504029 / 0.014522072472209685 0.02256500634957293 / 3.3209275234199355e-06
61 SQSTM1_3 5_179833009_G_A / 5_179822433_T_C / 5_179832842_G_C 0.005980563650762417 / 9.139203270628232e-06 / 0.04751023288058377 0.03979973429187952 / 0.0024949336391905503 / 0.0024314650981475784
62 PLEC_10 8_143935900_T_G / 8_143916360_A_G / 8_143917054_T_G / 8_143918739_A_C / 8_143919099_A_G / 8_143975295_A_G / 8_143919088_C_G / 8_143925285_C_T / 8_143927138_G_A / 8_143930017_C_T 0.006797512530240399 / 0.023847093097519808 / 0.003689478164571844 / 0.04007075765894598 / 0.03700251313887589 / 0.004544202282444686 / 0.03720602259473315 / 0.00047050570860322235 / 4.768364655899894e-05 / 0.0001893462141118206 0.0004960012901022363 / 0.00910116635228719 / 0.025072704488480143 / 2.138708286444241e-05 / 0.0010288222361061275 / 0.039226625991533134 / 0.009415988048366521 / 0.005460087145469642 / 0.008162873576760793 / 0.001268625363946227
63 CTSA_2 20_45893486_C_CT / 20_45894873_G_C 0.006806775220314732 / 0.009189197205389115 0.0011092438036515453 / 2.1137755776974608e-05
64 RND3_2 2_150471770_GA_G / 2_150487464_GA_G 0.006850825677580675 / 0.002608896214858801 0.004413096667547799 / 0.009852344084866441
65 DOCK1_3 10_127409601_G_A / 10_127248143_T_C / 10_127248024_G_T 0.0069346786852210966 / 0.001954876992257982 / 0.00010052759289672492 0.021839153568346648 / 0.030500963727912844 / 0.020184142497530616
66 MYOF_2 10_93341723_C_T / 10_93379679_T_C 0.007420864833221702 / 0.007547951219247403 1.0154009952651607e-05 / 0.0006543495060757152
67 PDS5B_2 13_32758091_C_T / 13_32675925_C_A 0.0075589035603876795 / 0.0017607048342993868 0.0023301391981286807 / 0.004241708828197667
68 HEXB_3 5_74696784_G_A / 5_74715459_CT_C / 5_74715716_T_A 0.007745014587458687 / 4.786425040147315e-06 / 8.479985392616748e-06 0.037654298343869685 / 0.0009700644073606587 / 0.0006894634360309071
69 TANC1_2 2_159136061_C_T / 2_159174959_G_C 0.00802472531176929 / 0.006460757964179747 0.017357470848779515 / 0.02749828370491698
70 ASPH_2 8_61642872_G_A / 8_61638365_TA_T 0.009092096160092012 / 2.1941312888430133e-05 9.242250914202104e-05 / 0.0033421074285719613
71 GSN_2 9_121326794_T_G / 9_121318750_T_C 0.009209877230841344 / 0.005427091425517584 0.014858234163842209 / 0.01549301533305157
72 ZNF292_3 6_87258847_A_G / 6_87260583_C_G / 6_87257934_G_C 0.0095880085401273 / 0.002653056510702511 / 0.037301685006945806 0.03664575782437445 / 0.02762172574455939 / 1.3565314335396872e-05
73 DTNBP1_2 6_15662660_G_A / 6_15651411_GA_G 0.016540725603977957 / 0.0034858875216863218 0.005994085134454578 / 0.0014349866138238813
74 SUGP2_2 19_19025732_C_T / 19_19008374_A_C 0.023033529177264773 / 0.0007995182905667767 0.008182273259557721 / 0.003040780848236827
75 ARID1B_5 6_157084627_G_A / 6_157084796_G_A / 6_156935454_GT_G / 6_156779132_C_G / 6_157206255_A_C 0.023572130650620228 / 0.0065953837312734045 / 0.00024483625735866694 / 0.0017474661626312965 / 0.008386743713695547 0.002480449952777213 / 0.003319459056638543 / 0.031030935390966245 / 0.0436791475273224 / 0.02302848816217332
76 DAZAP1_3 19_1432575_T_C / 19_1432578_A_C / 19_1421326_T_G 0.025717426655995912 / 0.012380456372647609 / 0.005697517435006497 0.008783799588482919 / 0.004625103934387489 / 0.03399063425366008
77 FAM76B_2 11_95786079_T_C / 11_95787545_T_C 0.026712661661121014 / 0.007093482411673812 0.008842917440325095 / 0.006738523037696958
78 CNTRL_3 9_121175323_T_C / 9_121167492_C_T / 9_121123912_AT_A 0.02777922136116125 / 0.03429035595633583 / 0.009987376618823514 0.008182636643218607 / 0.0016137010941682265 / 0.04001035208622377
79 IQCB1_4 3_121788384_A_T / 3_121807190_T_G / 3_121781663_A_T / 3_121781662_C_A 0.02873631298848243 / 0.04311975747619515 / 0.0034541658078948746 / 0.0008249500332497977 0.0011523884052119758 / 0.0035712731344638405 / 0.03680371502100786 / 0.031208890653500118
80 RRBP1_2 20_17636886_T_C / 20_17643440_G_A 0.03507251839152679 / 0.01991260739356573 1.9056892828600246e-06 / 0.0037236305333221867
81 ZNF84_2 12_133048690_A_T / 12_133048009_C_G 0.037210990330289934 / 0.040160599243354515 0.0028259388562976405 / 0.008314464537214374
82 MYCBP2_2 13_77098982_T_G / 13_77061586_T_C 0.03744183774757608 / 0.00310540257860121 0.0038229074053839733 / 0.030373685856290068
83 CALD1_3 7_134933124_A_G / 7_134891710_CTT_C / 7_134941283_GAAA_G 1.0681523332046643e-06 / 0.0055155972985149685 / 0.0008159520917689481 0.034156156662500686 / 0.006749784168432884 / 0.007042501841739691
84 RBMX_5 X_136874303_G_C / X_136874308_C_T / X_136876571_C_A / X_136880660_G_A / X_136879426_ATG_A 5.449363562924237e-05 / 3.4887046700057416e-07 / 6.172396284131506e-05 / 0.0054727241117358974 / 0.005573036956662709 0.0383480406291467 / 0.029837740684056712 / 0.015245783387880662 / 0.03540981223032282 / 0.0056729536604581
85 POLR2B_3 4_57005538_CA_C / 4_57023798_AT_A / 4_57024870_CT_C 5.482928793734288e-06 / 0.02167722586394588 / 0.0009543180256774695 0.018564114826717992 / 0.007472844031288456 / 0.0012756499136273938
86 SECISBP2_3 9_89319872_A_G / 9_89325866_A_T / 9_89348180_T_G 6.195560569127674e-05 / 0.0006584940331716795 / 0.0021577193257759702 0.020014055406942226 / 0.00642217291639139 / 0.01739212501206905
87 FBXO41_2 2_73258961_C_G / 2_73264474_A_C 7.08184621839895e-05 / 0.008886058285019023 0.010646018841909207 / 0.014910469893708134
88 TSPAN4_2 11_844057_C_G / 11_865650_C_G 8.251559449584364e-05 / 0.0042898689776822594 0.04166717005266338 / 0.02401170518473186
한편, 도 23에는 [표 1]에서 정리한 6개 암타입과 [표 14]에서 정리한 6개 약물타입에 대한 약물의 동반진단을 위한 바이오마커 검출에 사용되는 검사칩을 제작하는 방법이 도시되어 있다.
도 23에 도시된 바와 같이, 제1단계에서, [표 1] 및 [표 14]에 특정된 암타입 및 약물타입에 대한 각 바이오마커들에 대한 진단칩을 제작하거나, 상기 암타입 및 약물타입에 대한 모든 바이오마커만들거나 혹은 전체 을 모두 하나의 칩을 제작하고, 환자로부터 약물타입 또는 암타입과 관련된 FRH 마커에 대하여, 도 18의 도시된 실시예(혈액암의 약물타입 중의 하나인 EGFR pathway) 약물반응과 연관이 높은 한 세트의 FRH 및 특정암에 연관성이 높은 전체 FRH를 사용하여, 도 20의 Linear Regression 예측모델을 생성하는 형식으로 약물반응성을 예측할 수 있다. 따라서, 본 특허에서 정리한 6개 암타입(CancerClass) 및 6개 약물타입(DrugClass)에 특이한 FRH 바이오마커들을 이용하여 다양한 암 및 암약물 동반진단 칩을 도 23처럼 제작하여 활용할 수 있다.
마지막으로, 본 발명의 대상인 EGFR 약물에 대한 반응성 판단을 위한, 바이오 마커 조성물에 대하여 요약하면, [표 17]에 개시된 각각의 마커들이 유의성 있는 것으로 산출되었고, 이들 마커 중 PTGR1 유전자 발현과 연관된 마커 9_111597344_C_A 및 HDHD2 유전자 발현과 연관된 마커 18_47115026_C_T 가 주요한 마커 조합으로 판단되었다.
물론, 본 발명에 의한 바이오 마커 조성물은 이와 더불어 [표 21]에 정리된 추가적인 주요 바이오 마커들을 더 포함하여 다양한 조합에 의해 구성될 수 있다.
EGFR 약물 관련 추가 유의성 마커 일람
No. FRH Variants(마커)
1 CWC27_1 5_64977191_G_A
2 RNF217_1 6_125082793_A_C
3 NTN4_1 12_95738117_A_G
4 ZNF276_1 16_89737928_T_C
5 THBS1_1 15_39587486_A_C
6 TRIM29_1 11_120115474_C_A
7 APBB1_1 11_6401118_A_C
8 RASA3_1 13_113981629_G_A
9 TMX3_1 18_68700489_TA_T
10 RRP1_1 21_43791417_C_A
11 SIT1_1 9_35650461_G_A
12 FRG1_1 4_189955114_T_C
13 GTF2IRD1_1 7_74512993_A_G
14 DCP1A_1 3_53342054_G_C
15 SNRNP70_1 19_49101556_A_C
16 DDX20_1 1_111756207_T_C
17 TJP2_1 9_69237088_T_C
18 RHOJ_1 14_63269236_T_G
19 CXCL2_1 4_74098975_A_C
20 CARD8_1 19_48212012_T_C
21 TRMT2A_1 22_20117296_A_C
22 CRIM1_1 2_36479368_G_C
23 ELF3_1 1_202010991_C_G
24 UHRF2_1 9_6482002_G_T
25 ZBTB17_1 1_15944765_G_A
26 THRB_1 3_24143504_G_A
27 DHRS3_1 1_12568430_G_A
28 AGTPBP1_1 9_85672687_TA_T
29 DMTF1_1 7_87166631_TAG_T
30 CTBP2_1 10_124993226_T_G
31 BLK_1 8_11543171_G_A
32 EPCAM_1 2_47373742_AT_A
33 JUN_1 1_58782229_T_C
34 RBM5_1 3_50114164_G_T
35 CDKN2AIP_1 4_183445476_T_TGCACA
36 ZCCHC7_1 9_37302158_C_T
37 RAB8B_1 15_63262625_GTA_G
38 ODC1_1 2_10444350_A_C
39 CLTB_1 5_176397682_T_C
40 UIMC1_1 5_176906125_C_T
41 HCST_1 19_35903545_A_C
42 HSPA1B_1 6_31828722_C_G
43 MYL12B_1 18_3261766_G_T
44 RHBDF1_1 16_63885_G_GCC
45 UBE2N_1 12_93411182_C_T
46 SVIL_1 10_29524582_A_G
47 CCDC28B_1 1_32202026_A_C
48 ADARB1_1 21_45182568_CT_C
49 PPP4R1_1 18_9549876_A_G
50 CHD1L_1 1_147294440_C_G
51 LRP5_1 11_68424878_T_G
52 RND3_1 2_150487464_GA_G
53 LONRF1_1 8_12731670_C_A
54 BCOR_1 X_40052275_A_C
55 CCT8_1 21_29070160_C_T
56 ZNF330_1 4_141232702_CTT_C
57 CEP128_1 14_80916501_C_A
58 SH2D3A_1 19_6760997_A_G
59 IRF6_1 1_209790735_C_T
60 ITGAL_1 16_30484175_C_T
61 UEVLD_1 11_18558312_C_A
62 RNF141_1 11_10530725_T_C
63 THRAP3_1 1_36288866_G_C
64 PIAS4_1 19_4028785_C_T
65 SLC22A5_1 5_132390655_C_A
66 JAG1_1 20_10648877_T_C
67 SPI1_1 11_47358510_A_C
68 TECPR1_1 7_98223587_A_G
69 ZC3HC1_1 7_130023656_C_T
70 PDGFA_1 7_518698_G_C
71 C16orf74_1 16_85741569_G_A
72 DOT1L_1 19_2226677_G_A
73 CD19_1 16_28937656_A_C
74 P2RY2_1 11_73235099_G_C
75 EHF_1 11_34661000_T_C
76 EPS15L1_1 19_16392488_A_C
77 AGTRAP_1 1_11750007_T_G
78 LYRM7_1 5_131199511_CT_C
79 EPAS1_1 2_46346944_T_G
80 SIX4_1 14_60713618_C_T
81 PROM2_1 2_95281185_T_G
82 CAPN1_1 11_65186241_T_G
83 SRRM1_1 1_24669380_C_A
84 KLF3_1 4_38689006_A_C
85 THSD4_1 15_71765130_A_C
86 GPR107_1 9_130129853_A_G
87 TCERG1_1 5_146471685_A_C
88 ATG4C_1 1_62805167_G_T
89 SHQ1_1 3_72750552_C_T
90 DSG2_1 18_31524751_A_G
91 S100A14_1 1_153615226_C_T
92 CLDN4_1 7_73830773_C_T
93 OVOL2_1 20_18041767_A_G
94 CREB1_1 2_207577759_AT_A
95 BCLAF1_1 6_136278266_T_C
96 PKP2_1 12_32791480_G_T
97 ADAM9_1 8_39082624_ATTT_A
98 POLA1_1 X_24743203_T_G
99 FBXO10_1 9_37537560_G_A
100 CHMP4B_1 20_33811394_C_G
101 NOP56_1 20_2657708_GT_G
102 WIPF1_1 2_174585550_T_G
103 SCNN1A_1 12_6349108_G_C
104 C11orf80_1 11_66828178_C_T
105 ERP27_1 12_14914577_T_TGTGC
106 JAG2_1 14_105151295_T_G
107 SMARCC1_1 3_47693210_A_G
108 RNF138_1 18_32123591_T_C
109 THYN1_1 11_134248640_G_T
110 CYP24A1_1 20_54164725_T_C
111 SH2D3C_1 9_127766923_A_C
112 TGFA_1 2_70453242_T_G
113 CXCL16_1 17_4738773_T_G
114 AEN_1 15_88629905_A_C
115 SLC37A1_1 21_42534616_T_G
116 EPHA2_1 1_16148437_A_C
117 BCS1L_1 2_218660859_A_G
118 FBXO43_1 8_100137711_G_C
119 ADAM22_1 7_88075657_C_T
120 ADAMTSL1_1 9_18636052_G_T
121 ATXN2L_1 16_28834263_C_T
122 ZCCHC4_1 4_25313024_A_C
123 BCL2_1 18_63318646_T_C
124 EGR1_1 5_138466811_A_C
125 HS3ST1_1 4_11399218_T_C
126 LEF1_1 4_108078210_G_A
127 SRSF7_1 2_38748190_GT_G
128 KHSRP_1 19_6415784_T_C
129 YPEL1_1 22_21704297_T_C
130 TAPT1_1 4_16162866_G_A
131 SNRK_1 3_43348277_C_T
132 UGCG_1 9_111932206_A_G
133 DBF4B_1 17_44709262_G_C
134 HOOK1_1 1_59860373_C_G
135 ITGB3BP_1 1_63572436_G_T
136 DTX4_1 11_59205028_T_C
137 PPP1R13L_1 19_45391868_T_C
138 CBLC_1 19_44790103_A_C
139 B4GALT4_1 3_119212822_G_T
140 HSBP1_1 16_83809462_C_T
141 DTX1_1 12_113093500_A_T
142 TMEM51_1 1_15219789_A_C
143 ASAP2_1 2_9388476_A_C
144 PPP2R3C_1 14_35096667_C_A
145 WWC2_1 4_183280995_G_T
146 DMKN_1 19_35505819_C_T
147 EPHX1_1 1_225838589_T_G
148 PRPF4B_1 6_4051933_C_A
149 SNRNP40_1 1_31267793_A_G
150 LTBP3_1 11_65543062_T_C
151 BAG3_1 10_119651803_A_C
152 ANKRD2_1 10_97572685_T_G
153 ZNF451_1 6_57147971_C_A
154 ME2_1 18_50920583_C_T
155 DLG5_1 10_77811963_T_G
156 USP19_1 3_49111457_T_C
157 PDCD11_1 10_103433899_A_G
158 PDE1B_1 12_54577030_T_G
159 LONP1_1 19_5707040_C_G
160 KCNN3_1 1_154733143_A_C
161 FSD1_1 19_4304543_G_C
162 F2RL1_1 5_76832874_T_G
163 XPO4_1 13_20787374_T_C
164 TM4SF1_1 3_149375342_T_G
165 NPAS1_1 19_47035965_T_G
166 FAM78A_1 9_131260861_G_A
167 SYTL2_1 11_85734802_A_C
168 TMEM57_1 1_25431052_T_G
169 TUBA1A_1 12_49186397_T_C
170 ITPR3_1 6_33692820_C_T
171 ATM_1 11_108317650_T_C
172 SGTA_1 19_2769109_A_C
173 LCORL_1 4_17883673_A_AAC
174 MTDH_1 8_97660911_G_GATA
175 IKBKB_1 8_42320656_T_C
176 HNRNPD_1 4_82355277_C_CA
177 RAX_1 18_59272671_A_C
178 ZNF775_1 7_150397902_A_C
179 ALDH1A3_1 15_100885169_T_G
180 GNAI2_1 3_50252193_A_C
181 ZNF740_1 12_53187645_C_G
182 NTM_1 11_132307846_G_T
183 CHN1_1 2_174801578_A_G
184 PAX5_1 9_36923611_G_A
185 VAMP3_1 1_7781489_A_C
186 STK4_1 20_44995009_C_T
187 USP24_1 1_55075675_C_A
188 EXOSC10_1 1_11080567_C_A
189 TINAGL1_1 1_31585380_T_G
190 SPTLC3_1 20_13093456_G_T
191 PLEKHA6_1 1_204257921_A_C
192 PLXNC1_1 12_94219931_T_G
193 CAPN2_1 1_223717830_G_A
194 TJP1_1 15_29718124_TA_T
195 ASPHD2_1 22_26442326_G_A
196 IFT43_1 14_76082206_T_G
197 CASK_1 X_41578463_T_G
198 C21orf33_1 21_44144829_C_T
199 AFAP1L2_1 10_114294856_CCTAA_C
200 MEI1_1 22_41699656_A_C
201 HAUS6_1 9_19080551_G_A
202 LRRC8E_1 19_7899842_G_A
203 SMARCB1_1 22_23787366_GGC_G
204 DUT_1 15_48332272_A_C
205 MON1A_1 3_49911902_A_G
206 SASH1_1 6_148440274_CT_C
207 MAP1S_1 19_17726640_A_C
208 TOE1_1 1_45340381_G_A
209 CNOT7_1 8_17242848_C_T
210 CD244_1 1_160836124_G_A
211 EPM2AIP1_1 3_36992730_A_C
212 PRSS16_1 6_27249457_C_T
213 GPSM3_1 6_32192179_T_C
214 UGDH_1 4_39527132_G_A
215 AIG1_1 6_143060973_T_C
216 PMS1_1 2_189864380_G_A
217 PTGFR_1 1_78497752_G_A
218 AGPAT2_1 9_136674614_A_G
219 CBL_1 11_119278299_T_G
220 RAB37_1 17_74694690_G_A
221 GTPBP3_1 19_17338111_A_C
222 HDAC4_1 2_239053232_A_C
223 MBD3_1 19_1577118_C_T
224 CEP170_1 1_243164906_G_A
225 S100A16_1 1_153607964_A_G
226 DCK_1 4_71022615_CT_C
227 INF2_1 14_104713013_A_C
228 MYO6_1 6_75870526_T_C
229 CDS1_1 4_84635369_T_A
230 CTDSPL_1 3_37980672_C_T
231 EPB41L1_1 20_36187855_G_T
232 FGR_1 1_27617489_T_A
233 CAPRIN1_1 11_34051813_A_G
234 FOXC1_1 6_1612184_TA_T
235 ARHGEF6_1 X_136685627_G_A
236 BCAR3_1 1_93674923_G_C
237 BCL9L_1 11_118897861_A_C
238 TMEM201_1 1_9610425_T_A
239 RPS11_1 19_49496985_C_T
240 GMEB1_1 1_28690201_G_T
241 XRCC5_1 2_216109182_G_C
242 IL13RA1_1 X_118776541_G_T
243 PRR14_1 16_30651924_T_G
244 SH2B3_1 12_111418260_C_G
245 DTNBP1_1 6_15662698_A_G
246 PADI1_1 1_17228910_T_G
247 FAF1_1 1_50787989_A_G
248 RAB11FIP5_1 2_73075763_G_GGCCT
249 ZBTB40_1 1_22508509_T_G
250 BLCAP_1 20_37517746_T_C
251 KIF2A_1 5_62373627_T_G
252 HCFC1_1 X_153963207_T_G
253 HINFP_1 11_119121467_T_C
254 PRDM2_1 1_13823349_T_A
255 EIF4E_1 4_98902074_AT_A
256 PARVG_1 22_44206294_C_G
257 COX18_1 4_73064835_G_A
258 WDR33_1 2_127701640_C_G
259 ARHGAP9_1 12_57474460_G_A
260 GGCX_1 2_85550432_A_G
261 ZNF182_1 X_47983350_T_G
262 ANXA6_1 5_151117292_C_T
263 RPL14_1 3_40457950_G_A
264 FCHO2_1 5_73082876_ATT_A
265 RAB28_1 4_13473790_TATC_T
266 RNGTT_1 6_88769645_C_T
267 NNT_1 5_43602611_T_C
268 CLDN1_1 3_190308594_C_T
269 NRN1_1 6_6003752_C_T
270 ZNF423_1 16_49635837_A_C
271 YES1_1 18_732727_A_G
272 RAPGEF6_1 5_131433731_GA_G
273 MGAT4B_1 5_179799918_A_G
274 GATAD2B_1 1_153818250_T_C
275 FCRL5_1 1_157518564_T_C
276 ACSS2_1 20_34925819_A_C
277 CTR9_1 11_10773884_CAAAAA_C
278 INPP5B_1 1_37872885_G_T
279 RPAIN_1 17_5421266_TTC_T
280 RCHY1_1 4_75509142_T_A
281 RASSF7_1 11_562335_A_C
282 NKX3-2_1 4_13541263_A_G
283 IGFBP3_1 7_45917562_GT_G
284 LTBR_1 12_6385217_T_C
285 GNG2_1 14_51950694_A_C
286 NAP1L1_1 12_76084896_T_C
287 GULP1_1 2_188589974_C_CT
288 PXDC1_1 6_3727577_C_G
289 WDR12_1 2_202897546_T_A
290 TMBIM6_1 12_49742405_G_A
291 PPM1D_1 17_60656452_CA_C
292 RPA2_1 1_27907061_GA_G
293 PRR3_1 6_30562126_T_G
294 RBM28_1 7_128310614_C_A
295 ENAH_1 1_225519569_GAAAA_G
296 KIAA0922_1 4_153592379_A_G
297 TRIM2_1 4_153276097_A_G
298 ATP8B1_1 18_57731374_T_C
299 QSOX1_1 1_180178802_A_G
300 MB_1 22_35607296_C_G
301 ORAI2_1 7_102433548_G_A
302 WNT7B_1 22_45931386_G_A
303 PIKFYVE_1 2_208330748_GT_G
304 ARHGAP32_1 11_128972609_T_G
305 SH3YL1_1 2_249571_C_T
306 DEPDC5_1 22_31843912_CT_C
307 VSIG10_1 12_118073908_T_G
308 SLX4_1 16_3595722_A_C
309 REEP3_1 10_63621980_A_G
310 FARSB_1 2_222571709_T_C
311 NDUFS3_1 11_47578800_A_G
312 HIBADH_1 7_27538786_G_A
313 SCLT1_1 4_128957191_A_C
314 SLC20A2_1 8_42439475_C_T
315 LMO7_1 13_75855483_C_A
316 SREBF2_1 22_41897136_G_C
317 SPAG1_1 8_100194395_C_A
318 NCAM1_1 11_113270137_A_G
319 ATP1B1_1 1_169111407_C_G
320 PLXNB2_1 22_50281752_C_G
321 PFAS_1 17_8269414_A_G
322 CEP152_1 15_48762574_G_C
323 GNRH1_1 8_25423267_A_G
324 CARD10_1 22_37508612_T_C
325 COL6A3_1 2_237351090_T_G
326 RBM12B_1 8_93733158_G_T
327 ITPKC_1 19_40737666_A_C
328 ARHGAP31_1 3_119390922_C_T
329 GRAMD1A_1 19_35022992_C_T
330 SAE1_1 19_47131056_T_G
331 MICALL1_1 22_37924607_T_G
332 GABRB2_1 5_161336809_G_A
333 SPINT2_1 19_38287977_A_G
334 ATXN7_1 3_63990247_A_C
335 TATDN2_1 3_10248824_C_CT
336 AP4E1_1 15_50968319_T_G
337 CHST2_1 3_143121243_A_G
338 PRKAG2_1 7_151560579_A_G
339 C16orf45_1 16_15596596_T_G
340 SULT2B1_1 19_48591514_T_G
341 DSTN_1 20_17600864_A_G
342 TPD52L2_1 20_63889961_A_C
343 E2F2_1 1_23521217_C_G
344 TSEN34_1 19_54192354_T_G
345 FOXN3_1 14_89162512_A_C
346 MND1_1 4_153408912_G_GTATATA
347 ZDHHC5_1 11_57696028_T_C
348 ARMCX4_1 X_101488321_C_G
349 P2RY11_1 19_10115376_G_A
350 C1orf198_1 1_230839028_T_C
351 TPTE2_1 13_19425773_G_A
352 TMEM206_1 1_212379769_G_C
353 REEP5_1 5_112891583_T_A
354 CNNM4_1 2_96798981_T_G
355 GPR65_1 14_88011069_C_T
356 ZDHHC7_1 16_84981848_T_G
357 KCNAB3_1 17_7925552_G_A
358 ASNSD1_1 2_189670812_C_T
359 LY9_1 1_160814485_A_C
360 SKIV2L2_1 5_55307994_T_C
361 MADD_1 11_47325027_T_C
362 ITPRIPL1_1 2_96325641_T_G
363 SDC4_1 20_45330303_T_G
364 SLC2A8_1 9_127398490_G_A
365 CSF2RB_1 22_36923285_A_C
366 WWTR1_1 3_149669685_C_T
367 PEX10_1 1_2410431_A_C
368 SCMH1_1 1_41033845_T_G
369 WNT10A_1 2_218882471_A_C
370 SIRT4_1 12_120303510_G_GAA
371 SLC25A43_1 X_119451980_A_G
372 SLC35F5_1 2_113723196_TA_T
373 PLEKHA5_1 12_19369550_A_AAAAG
374 RASEF_1 9_82982805_CAGAG_C
375 RASSF2_1 20_4797919_T_G
376 ANKRD44_1 2_197099965_G_A
377 ZFYVE19_1 15_40812591_A_AAG
378 TMEM2_1 9_71704688_T_G
379 TMEM159_1 16_21174063_G_A
380 PEX13_1 2_61045783_A_T
381 BCAR1_1 16_75229126_T_A
382 SLC25A38_1 3_39389590_G_A
383 ING5_1 2_241711916_A_C
384 AHR_1 7_17339074_A_C
385 ETV1_1 7_13900838_A_C
386 FUS_1 16_31191353_T_G
387 ELMO1_1 7_36986095_A_C
388 FLI1_1 11_128772826_T_G
389 RBPJ_1 4_26321137_C_A
390 TGM1_1 14_24260894_A_C
391 MAD2L2_1 1_11680485_C_A
392 CCDC66_1 3_56613771_T_C
393 E2F3_1 6_20402547_A_C
394 TRIM47_1 17_75875198_A_C
395 LACTB2_1 8_70657773_A_C
396 S100A13_1 1_153619154_A_C
397 PRKCZ_1 1_2059508_T_G
398 KIAA0430_1 16_15601202_A_G
399 PARP1_1 1_226377365_T_C
400 VMP1_1 17_59841357_A_C
401 TRPM7_1 15_50619668_AT_A
402 RPL11_1 1_23695353_C_A
403 RHPN2_1 19_33002924_G_A
404 MAST3_1 19_18107675_A_T
405 SACS_1 13_23354711_A_C
406 ZBTB4_1 17_7463332_C_G
407 SSH3_1 11_67309455_A_C
408 STAU1_1 20_49153934_T_C
409 PRSS22_1 16_2853046_G_C
410 SRRD_1 22_26488073_G_A
411 ITGB8_1 7_20399120_C_G
412 FLII_1 17_18245630_C_G
413 TMEM40_1 3_12769284_C_T
414 SLC19A1_1 21_45512453_A_C
415 FBN1_1 15_48425289_G_T
416 TMC4_1 19_54160564_G_A
417 TACC2_1 10_122132454_G_A
418 HEATR5A_1 14_31315848_T_C
419 SLC25A24_1 1_108161212_C_T
420 TMEM39B_1 1_32091713_A_C
421 ANKRD22_1 10_88831974_A_C
422 SFSWAP_1 12_131753058_C_G
423 C1orf54_1 1_150279750_G_C
424 SEPT10_1 2_109564377_G_T
425 FOS_1 14_75280999_A_C
426 AARS2_1 6_44301927_CAGG_C
427 EMP1_1 12_13211531_T_G
428 FBXO2_1 1_11648995_C_G
429 UBE3A_1 15_25408653_C_A
430 GPC1_1 2_240451007_T_G
431 ACTN4_1 19_38728028_T_G
432 EPB41L4B_1 9_109182980_T_C
433 SERTAD3_1 19_40441466_GGATC_G
434 WHSC1L1_1 8_38315857_G_C
435 QRICH1_1 3_49076524_TAAA_T
436 CAMSAP3_1 19_7618018_A_C
437 TCHP_1 12_109907472_T_G
438 TUFT1_1 1_151565936_G_A
439 CHMP1A_1 16_89649256_C_T
440 LAMB2_1 3_49125146_T_G
441 PNRC2_1 1_23961290_GCTT_G
442 MARVELD2_1 5_69419733_A_C
443 SLC22A18_3 11_2919250_T_G / 11_2903361_G_A / 11_2919268_T_G
444 SH3D19_3 4_151148254_TACACACACACACACAC_T / 4_151122202_T_C / 4_151148202_G_T
445 LARS2_5 3_45474156_T_C / 3_45476267_G_A / 3_45488909_G_A / 3_45500591_T_C / 3_45417241_A_G
446 SRGAP1_2 12_64142411_T_C / 12_64097222_GTT_G
447 ALDH3A1_3 17_19742310_G_A / 17_19748298_C_T / 17_19740913_C_G
448 LPIN3_5 20_41345676_A_G / 20_41358461_T_G / 20_41358465_C_G / 20_41340873_C_A / 20_41350009_T_G
449 LAMB3_3 1_209626885_C_T / 1_209626996_C_T / 1_209630438_C_T
450 RAC1_2 7_6398689_A_C / 7_6401802_T_G
451 CERKL_2 2_181603835_A_C / 2_181678048_T_G
452 MTO1_2 6_73492090_C_T / 6_73473277_C_CAGAT
453 SUMF1_2 3_4419885_G_A / 3_3846683_A_C
454 WDFY4_5 10_48946696_T_C / 10_48774557_A_C / 10_48823427_C_T / 10_48826590_T_A / 10_48709976_C_T
455 DSC2_3 18_31091249_T_G / 18_31093490_T_G / 18_31080273_C_T
456 MBD1_4 18_50276088_C_A / 18_50276601_A_G / 18_50275492_T_G / 18_50275430_G_A
457 KIAA1671_2 22_25029373_T_C / 22_25170874_A_C
458 MET_3 7_116740945_T_G / 7_116757685_T_G / 7_116740947_C_G
459 RCBTB1_2 13_49585356_T_A / 13_49533768_G_A
460 PPL_4 16_4883459_A_G / 16_4894423_G_C / 16_4901058_T_G / 16_4891747_T_G
461 TMEM63A_3 1_225856800_GC_G / 1_225856891_C_T / 1_225845173_C_T
462 KDM4B_5 19_5110783_A_G / 19_5047680_G_A / 19_5111856_C_T / 19_5152376_T_C / 19_5114105_T_G
463 TAF4B_2 18_26286027_C_A / 18_26293570_AT_A
464 MAP2K7_3 19_7905750_A_G / 19_7911231_T_C / 19_7910579_A_C
465 EGFR_5 7_55160480_C_T / 7_55170771_T_G / 7_55205133_G_A / 7_55181370_G_A / 7_55205662_A_C
466 MED4_2 13_48079728_CAAA_C / 13_48077399_A_AT
467 PSMG1_2 21_39183425_G_C / 21_39175728_T_C
468 SYMPK_3 19_45823908_G_A / 19_45835234_G_A / 19_45842628_T_C
469 CNKSR1_6 1_26180299_A_G / 1_26181802_G_A / 1_26181989_T_C / 1_26183270_A_C / 1_26184255_A_C / 1_26180691_T_G
470 LGR4_3 11_27373900_C_T / 11_27380156_G_A / 11_27368981_G_A
471 VTCN1_3 1_117157003_C_T / 1_117172345_T_C / 1_117172578_ATTT_A
472 CRBN_6 3_3151010_G_T / 3_3152273_A_C / 3_3154589_AT_A / 3_3175444_AT_A / 3_3179746_C_T / 3_3150840_A_ATAAC
473 SMCHD1_5 18_2707621_G_A / 18_2724932_A_T / 18_2763699_C_T / 18_2656105_T_G / 18_2795854_A_G
474 HDAC11_2 3_13496579_C_G / 3_13496863_T_TG
475 PIK3CD_4 1_9720778_T_G / 1_9721354_C_G / 1_9722498_C_T / 1_9710297_C_T
476 GCDH_3 19_12891586_G_C / 19_12891749_T_G / 19_12899706_A_G
477 SEC11C_2 18_59152698_T_C / 18_59158845_T_C
478 SAFB_2 19_5667193_AC_A / 19_5668433_GT_G
479 ATP6V1B2_3 8_20212278_G_C / 8_20218183_C_A / 8_20214681_A_G
480 PUS3_4 11_125896149_C_A / 11_125896278_A_C / 11_125896309_G_C / 11_125896312_C_T
481 XDH_2 2_31383804_G_A / 2_31398732_T_C
482 WDR7_4 18_56679573_T_G / 18_56781547_G_A / 18_56815915_A_G / 18_57027330_A_ACGGC
483 GJB2_2 13_20189503_C_T / 13_20189241_T_C
484 NFATC1_5 18_79486406_T_G / 18_79486978_G_A / 18_79449015_A_G / 18_79451175_T_C / 18_79467476_A_G
485 TMEM141_2 9_136791905_T_C / 9_136791680_A_G
486 GON4L_3 1_155750010_A_G / 1_155813972_C_T / 1_155826993_A_G
487 THOC1_4 18_218753_C_A / 18_259800_G_GA / 18_264012_G_A / 18_260303_A_C
488 MOCOS_3 18_36268700_A_ATACAT / 18_36195408_G_A / 18_36195416_C_T
489 TBC1D1_2 4_37920795_A_T / 4_38102880_CA_C
490 MYOF_6 10_93402739_A_T / 10_93335910_A_G / 10_93341723_C_T / 10_93349980_G_A / 10_93456833_C_T / 10_93379679_T_C
491 RBBP5_4 1_205096605_G_T / 1_205105296_C_T / 1_205121757_C_G / 1_205101436_A_G
492 CLASP2_2 3_33577059_G_GA / 3_33684322_GA_G
493 PHACTR1_2 6_13206050_C_T / 6_12749854_G_C
494 ANAPC4_3 4_25396670_G_C / 4_25396674_T_G / 4_25405734_A_G
495 PSMD5_2 9_120820914_A_G / 9_120824459_T_G
496 ABCC3_4 17_50677651_A_G / 17_50687493_T_G / 17_50677654_A_G / 17_50661130_G_A
497 PDS5A_8 4_39826222_A_G / 4_39908552_GA_G / 4_39920322_A_G / 4_39928282_TCA_T / 4_39874433_GT_G / 4_39902522_ATT_A / 4_39922752_TAA_T / 4_39849438_CAA_C
498 ARID1B_3 6_157084627_G_A / 6_157084796_G_A / 6_156779262_G_GCGC
499 ATP6V1D_2 14_67347484_T_C / 14_67347517_C_T
500 TSPAN15_2 10_69506088_T_G / 10_69506076_T_C
501 MLH1_3 3_37007142_A_G / 3_37012077_A_G / 3_37042249_A_G
502 MCPH1_10 8_6563013_A_G / 8_6414878_G_T / 8_6415022_A_C / 8_6442011_A_G / 8_6444662_G_C / 8_6621439_C_G / 8_6621761_G_T / 8_6643023_C_T / 8_6643230_C_G / 8_6445504_G_A
503 APLP2_2 11_130110790_G_A / 11_130141602_T_C
504 GDF11_2 12_55743444_T_G / 12_55743453_A_G
505 DHRS1_2 14_24296416_G_A / 14_24296478_G_A
506 HMBOX1_2 8_29019076_C_G / 8_29049138_T_G
507 FAM129B_3 9_127525147_A_C / 9_127531490_GA_G / 9_127578821_C_G
508 SQRDL_3 15_45676245_C_G / 15_45659211_A_T / 15_45659215_T_A
509 PAWR_3 12_79621127_A_T / 12_79621127_A_C / 12_79690012_G_C
510 ZMYM4_2 1_35386039_A_G / 1_35398970_A_G
511 PNISR_3 6_99400577_G_T / 6_99400380_A_T / 6_99400680_T_C
512 KCTD1_2 18_26455686_TTTTG_T / 18_26455824_G_A
513 YEATS4_4 12_69360050_G_A / 12_69360067_T_C / 12_69365771_AT_A / 12_69359732_G_C
514 MYH14_4 19_50257459_C_G / 19_50268152_A_C / 19_50223372_A_C / 19_50210705_A_C
515 TNRC6B_3 22_40246081_G_A / 22_40322746_C_G / 22_40270313_CTT_C
516 INTS9_7 8_28780706_C_T / 8_28787754_C_T / 8_28793781_A_C / 8_28793783_A_C / 8_28835266_C_T / 8_28775581_A_C / 8_28775811_A_C
517 SLC9A2_2 2_102708404_T_C / 2_102683152_T_C
518 CABYR_2 18_24159761_T_C / 18_24143046_A_T
519 GTF3A_3 13_27435783_G_C / 13_27434894_G_C / 13_27424632_T_C
520 C17orf80_2 17_73243051_A_T / 17_73243095_T_G
521 SMU1_3 9_33042147_G_GC / 9_33048282_A_C / 9_33062151_T_C
522 APP_3 21_25881669_T_G / 21_25982373_C_A / 21_26053118_T_G
523 SF3A2_2 19_2247907_A_C / 19_2248684_C_T
524 MCM3AP_14 21_46242985_CA_C / 21_46245202_GAAGA_G / 21_46254361_G_A / 21_46256797_G_A / 21_46257020_T_C / 21_46258860_A_G / 21_46261213_T_C / 21_46265873_T_C / 21_46266025_A_G / 21_46266238_C_T / 21_46266260_T_C / 21_46272884_C_T / 21_46275481_C_G / 21_46285323_T_C
525 CLIP4_2 2_29160508_G_A / 2_29167435_A_G
526 TSC22D1_3 13_44574373_G_T / 13_44574380_T_G / 13_44573675_A_G
527 PKP3_3 11_403980_G_A / 11_404317_C_T / 11_397331_G_C
528 CASP8AP2_4 6_89867828_C_A / 6_89846678_CT_C / 6_89854793_T_G / 6_89867387_T_G
529 SUGP1_3 19_19297181_T_G / 19_19320614_T_G / 19_19321154_G_T
530 MTMR14_2 3_9701714_TGGAG_T / 3_9688859_C_T
531 RIOK2_2 5_97167674_T_C / 5_97179013_C_G
532 HCLS1_5 3_121631746_C_A / 3_121642799_G_A / 3_121642940_G_A / 3_121647276_C_T / 3_121647530_A_G
533 USP20_2 9_129868385_TGAC_T / 9_129868775_T_C
534 OGT_3 X_71555839_AT_A / X_71555852_A_G / X_71556880_G_A
535 ILF3_4 19_10677068_C_G / 19_10683073_A_G / 19_10683954_G_T / 19_10689074_T_C
536 AKAP17A_6 X_1593528_G_T / X_1593824_T_C / X_1593829_A_C / X_1593416_T_G / X_1599467_G_A / X_1601004_C_G
537 HLA-DPB1_25 6_33084838_T_C / 6_33086094_A_G / 6_33086100_G_A / 6_33086430_A_G / 6_33086431_C_T / 6_33086458_T_G / 6_33086503_T_C / 6_33086504_G_A / 6_33086525_T_C / 6_33084940_A_C / 6_33084942_G_A / 6_33084946_C_G / 6_33084959_G_A / 6_33086548_G_C / 6_33086623_T_C / 6_33086627_A_G / 6_33086636_T_G / 6_33086637_T_A / 6_33084934_T_C / 6_33086390_G_A / 6_33086399_T_A / 6_33086400_T_C / 6_33086554_T_C / 6_33086565_T_A / 6_33084918_T_G
538 ERBB2_7 17_39723335_A_G / 17_39725167_A_G / 17_39727303_T_G / 17_39723531_A_C / 17_39728154_A_C / 17_39709434_A_C / 17_39728753_A_G
539 CNOT10_5 3_32773739_A_T / 3_32705030_A_G / 3_32717271_G_A / 3_32727933_TAA_T / 3_32704796_GT_G
540 BTAF1_3 10_91959744_A_G / 10_91959746_A_G / 10_92024732_G_GTTTTTTTGTT
541 KDM2B_2 12_121579961_G_A / 12_121444386_T_G
542 OSBPL8_3 12_76371622_A_G / 12_76459031_C_T / 12_76389816_G_A
543 SPATS2L_4 2_200477598_G_T / 2_200412421_T_G / 2_200477943_T_G / 2_200473083_GAA_G
544 KMT2C_2 7_152273692_G_A / 7_152177504_T_G
545 C3_8 19_6679370_G_T / 19_6679500_C_T / 19_6679552_T_C / 19_6693625_A_G / 19_6710771_G_T / 19_6713164_G_C / 19_6713251_G_A / 19_6718376_G_C
546 NFX1_3 9_33290534_A_G / 9_33290690_G_C / 9_33344254_T_A
547 KATNAL2_4 18_46963135_T_TGC / 18_46969062_T_TGC / 18_47028569_T_TGC / 18_47069438_A_T
548 PLRG1_8 4_154538042_A_T / 4_154539961_T_C / 4_154540535_A_C / 4_154540996_A_T / 4_154544383_A_G / 4_154545783_T_C / 4_154546035_A_G / 4_154548807_G_GA
549 EDN1_2 6_12295840_T_G / 6_12295843_T_G
550 RABEP1_2 17_5381248_TAA_T / 17_5361621_C_T
551 RUNX3_2 1_24907301_T_G / 1_24907326_T_G
552 ARID3A_2 19_929678_G_A / 19_965056_A_C
553 SETD2_6 3_47037622_G_A / 3_47083895_G_A / 3_47084411_A_C / 3_47084426_CT_C / 3_47101417_TCC_T / 3_47121171_A_G
554 MYO1E_4 15_59272288_G_C / 15_59223315_G_A / 15_59178167_C_T / 15_59138181_A_C
555 SUGP2_5 19_19024510_A_G / 19_19025732_C_T / 19_18994964_G_A / 19_19026233_T_A / 19_19010089_T_G
556 KLHL18_3 3_47319581_T_G / 3_47344095_C_A / 3_47322481_G_T
557 TYSND1_2 10_70138599_C_T / 10_70140172_G_A
558 EIF1B_5 3_40309993_C_T / 3_40311393_C_T / 3_40311934_CAG_C / 3_40311768_T_G / 3_40309649_C_G
559 C14orf79_2 14_104991443_T_G / 14_104992803_A_C
560 SLC52A3_2 20_761203_A_G / 20_763790_T_G
561 HDAC5_2 17_44087216_A_G / 17_44077102_A_G
562 TCF7L2_4 10_112951117_C_T / 10_113165703_A_C / 10_113165557_GA_G / 10_113141157_T_G
563 DSP_2 6_7577915_A_C / 6_7581379_A_G
564 GAS7_3 17_9943314_G_A / 17_9943407_C_A / 17_9940079_A_C
565 ARHGEF5_5 7_144365079_A_C / 7_144371121_T_C / 7_144371117_T_G / 7_144364997_T_C / 7_144365475_T_C
566 PTPRU_3 1_29275579_A_C / 1_29310715_T_G / 1_29255395_A_C
567 TTC39A_2 1_51288088_T_G / 1_51295930_G_T
568 KRT15_3 17_41516910_C_A / 17_41518370_T_G / 17_41518744_A_C
569 UBXN8_5 8_30744093_TC_T / 8_30744288_C_T / 8_30751256_A_G / 8_30751544_T_G / 8_30751561_A_T
570 SMARCA4_3 19_11003321_G_T / 19_11010261_C_T / 19_11026459_T_C
571 PSMD6_2 3_64018733_C_CA / 3_64023832_T_C
572 CCDC18_7 1_93226524_AAT_A / 1_93232665_C_G / 1_93180876_T_C / 1_93221838_T_C / 1_93239253_G_A / 1_93226314_TG_T / 1_93180563_T_G
573 MKRN2_2 3_12572367_T_C / 3_12576770_C_T
574 POU2F2_2 19_42122415_A_C / 19_42116791_T_G
575 CSNK1G2_2 19_1941300_C_CG / 19_1978367_A_C
576 NADK_4 1_1754601_G_T / 1_1755504_T_C / 1_1755523_C_T / 1_1757030_C_G
577 CD151_2 11_837662_TG_T / 11_835877_C_T
578 ATP5A1_9 18_46098069_T_C / 18_46086016_C_T / 18_46086895_T_C / 18_46086986_C_A / 18_46087562_T_C / 18_46088355_G_T / 18_46090014_T_C / 18_46098295_T_G / 18_46090084_G_T
579 ACTR8_2 3_53876892_G_GT / 3_53876872_GA_G
580 KDM4C_3 9_7105548_G_C / 9_7170165_G_A / 9_7174813_T_A
581 AZI2_2 3_28331971_C_CA / 3_28340396_A_T
582 SERTAD4_2 1_210241533_TC_T / 1_210241536_T_C
583 USP15_4 12_62302696_T_G / 12_62383784_G_T / 12_62404146_G_T / 12_62335441_G_C
584 DOCK1_3 10_127012556_G_A / 10_127444251_G_A / 10_127248024_G_T
585 ITGB4_4 17_75736347_G_A / 17_75739839_G_A / 17_75742534_T_C / 17_75754823_A_C
586 ZDHHC17_2 12_76843188_G_A / 12_76815330_A_G
587 STEAP4_2 7_88282586_G_A / 7_88283906_C_T
588 SON_2 21_33553093_A_C / 21_33553095_T_C
589 SUZ12_2 17_31937449_T_G / 17_31937443_C_G
590 ZNF708_5 19_21294577_C_T / 19_21309149_T_A / 19_21309260_G_A / 19_21294601_T_G / 19_21310453_A_T
591 NPAT_3 11_108173261_C_T / 11_108188273_T_C / 11_108222481_A_T
592 HSPG2_4 1_21848107_A_G / 1_21857246_A_G / 1_21854055_T_C / 1_21885485_A_C
593 TOP2B_6 3_25618603_G_GT / 3_25620066_T_TA / 3_25630287_C_T / 3_25632344_A_C / 3_25632600_C_A / 3_25638247_T_C
594 MUC16_3 19_8894929_A_T / 19_8979498_T_G / 19_8957088_C_T
595 TMEM144_3 4_158244471_A_C / 4_158253356_T_G / 4_158253361_T_G
596 SDC1_2 2_20204203_T_G / 2_20202279_A_C
597 RBM6_7 3_50054242_G_T / 3_50054246_C_T / 3_50054250_C_T / 3_50054257_G_T / 3_50054263_T_G / 3_50075177_T_G / 3_50066484_G_A
598 FIP1L1_2 4_53377738_T_C / 4_53414538_G_GA
599 BAZ1A_6 14_34773800_G_A / 14_34761774_C_T / 14_34761902_A_T / 14_34771458_C_G / 14_34780118_A_G / 14_34862082_G_A
600 ABLIM1_2 10_114468289_G_T / 10_114613516_C_T
601 KCTD11_3 17_7356629_G_T / 17_7356036_T_C / 17_7353417_T_G
602 MICALL2_5 7_1442358_T_G / 7_1448634_T_G / 7_1438692_G_A / 7_1438940_G_A / 7_1434765_T_C
603 RFC1_4 4_39304977_A_C / 4_39317086_A_G / 4_39327482_G_A / 4_39366034_T_C
604 AP1M2_5 19_10572926_C_T / 19_10579645_C_T / 19_10587097_A_G / 19_10587125_G_T / 19_10579014_TC_T
605 RPS23_2 5_82278173_C_T / 5_82278363_C_T
606 BARX2_2 11_129436792_A_C / 11_129436677_C_T
607 LRRC1_3 6_53913863_T_G / 6_53920478_C_A / 6_53899709_T_G
608 POGZ_3 1_151423306_T_C / 1_151407350_A_C / 1_151459156_T_C
609 PRKCI_2 3_170275187_CTTT_C / 3_170263168_CAAAAA_C
610 PGBD1_2 6_28296652_T_G / 6_28298177_A_T
611 LGALS8_3 1_236537373_GAGC_G / 1_236539197_AGTTT_A / 1_236551447_T_C
612 CYP4F11_7 19_15913852_G_C / 19_15914366_C_T / 19_15924707_G_A / 19_15927524_G_A / 19_15927580_G_T / 19_15929482_A_G / 19_15929663_T_C
613 ZNF24_3 18_35337816_G_GA / 18_35337680_T_C / 18_35344446_G_A
614 ANKS6_2 9_98796162_G_A / 9_98778486_A_C
615 POLR2B_6 4_56995192_C_T / 4_57010789_G_A / 4_57015549_G_A / 4_57025073_G_A / 4_57005234_AT_A / 4_57023798_AT_A
616 CDC42BPB_3 14_102939620_T_G / 14_102952453_T_G / 14_102945931_T_C
617 WDR62_3 19_36058788_C_T / 19_36084743_G_A / 19_36094002_C_T
618 PLCB2_2 15_40298884_T_G / 15_40297623_G_A
619 ZEB1_4 10_31461157_A_C / 10_31521191_A_C / 10_31521414_A_T / 10_31461247_AT_A
620 NDUFAF4_2 6_96891399_CA_C / 6_96896910_G_A
621 PHIP_9 6_78947674_G_A / 6_78954723_T_C / 6_78955031_T_C / 6_78955493_T_A / 6_78969860_A_G / 6_78985312_C_T / 6_78998206_C_T / 6_79043075_T_C / 6_78947709_T_C
622 C6orf203_2 6_107044172_C_T / 6_107051038_GTTTTC_G
623 RIOK1_2 6_7390137_G_T / 6_7410502_GT_G
624 STX2_3 12_130796169_T_C / 12_130821769_C_G / 12_130827084_G_A
625 DOCK9_6 13_98797273_A_G / 13_98888796_T_A / 13_98848509_C_T / 13_98902701_G_A / 13_98883901_TA_T / 13_98977850_C_T
626 ADAM15_4 1_155056046_G_A / 1_155058081_A_C / 1_155058900_C_T / 1_155053372_T_G
627 ZNF430_3 19_21020746_C_T / 19_21033730_G_A / 19_21022725_C_T
628 SLC41A2_2 12_104866497_A_G / 12_104805360_A_C
629 ARHGAP5_2 14_32092970_T_C / 14_32154828_T_C
630 CTSB_5 8_11848168_C_G / 8_11853379_G_C / 8_11847933_G_T / 8_11852665_T_C / 8_11848361_G_A
631 INTS10_7 8_19824136_G_A / 8_19825034_A_G / 8_19825081_A_G / 8_19832122_T_C / 8_19823225_T_C / 8_19823468_C_T / 8_19820404_G_A
632 CHAF1A_3 19_4406163_G_A / 19_4442339_C_T / 19_4422720_A_G
633 MDC1_2 6_30711769_A_C / 6_30704316_T_G
634 DYRK1A_3 21_37420484_TGGG_T / 21_37506256_A_C / 21_37505200_T_G
635 SMPDL3B_2 1_27949055_T_G / 1_27956116_T_G
636 EVPL_2 17_76023471_A_C / 17_76023459_T_G
637 TOM1L1_5 17_54914767_TA_T / 17_54930294_T_G / 17_54936619_A_G / 17_54936871_A_ATTAAG / 17_54949462_TAAAAG_T
638 PPP6R2_6 22_50437806_T_C / 22_50444323_CT_C / 22_50438097_C_G / 22_50439767_G_A / 22_50444161_G_A / 22_50435068_C_T
639 DAB2IP_2 9_121772524_T_G / 9_121760326_A_C
640 WRN_8 8_31096749_C_T / 8_31124455_G_T / 8_31141606_C_T / 8_31167122_C_T / 8_31068263_T_G / 8_31096728_GT_G / 8_31081188_G_A / 8_31154721_C_G
641 SEC63_2 6_107876794_A_G / 6_107876670_C_A
642 MAU2_6 19_19336127_G_A / 19_19338794_G_A / 19_19338877_G_T / 19_19342712_T_G / 19_19342751_C_A / 19_19344019_G_A
643 CDCP1_3 3_45091085_A_T / 3_45091145_T_C / 3_45095296_A_G
644 NKTR_2 3_42630618_G_C / 3_42636885_C_A
645 GSN_3 9_121321305_A_C / 9_121326911_A_C / 9_121282717_C_T
646 MTR_3 1_236885200_A_G / 1_236897645_CT_C / 1_236812798_T_G
647 DNAH1_4 3_52395506_T_G / 3_52398167_T_C / 3_52375405_A_G / 3_52394972_C_A
648 NDUFS7_6 19_1388539_C_T / 19_1389518_C_A / 19_1390758_C_A / 19_1391101_A_C / 19_1387920_T_G / 19_1387934_A_G
649 TLN1_4 9_35711809_G_T / 9_35712826_G_A / 9_35700530_A_AGTTT / 9_35707057_C_T
650 PARPBP_3 12_102164766_G_C / 12_102165930_A_C / 12_102195841_T_TTAAAAA
651 FZD6_2 8_103300204_A_G / 8_103318860_G_C
652 ITPR1_10 3_4651972_C_T / 3_4673329_A_C / 3_4712028_A_G / 3_4814550_G_A / 3_4645814_T_A / 3_4652327_G_A / 3_4653996_G_A / 3_4717319_C_T / 3_4652159_T_G / 3_4516699_C_T
653 LAMA5_11 20_62307035_T_C / 20_62308863_T_C / 20_62315711_A_C / 20_62325178_T_C / 20_62327158_G_A / 20_62327540_T_G / 20_62310033_T_G / 20_62327738_A_C / 20_62332572_T_G / 20_62327734_A_C / 20_62345568_A_G
654 MAPRE2_2 18_35132001_G_GT / 18_35070377_A_G
655 PCM1_14 8_17938873_A_G / 8_17938874_C_T / 8_17947156_G_A / 8_17957171_G_C / 8_17962063_C_T / 8_17962252_A_G / 8_17972247_C_CAA / 8_17993739_C_A / 8_18010736_C_A / 8_18014089_T_A / 8_18014110_A_C / 8_18027462_G_A / 8_18027582_T_C / 8_17963329_A_C
656 LAMC2_2 1_183207851_G_T / 1_183207864_G_T
657 FAT1_2 4_186706505_TAAAAAA_T / 4_186628213_A_C
658 SQSTM1_3 5_179833009_G_A / 5_179822433_T_C / 5_179832842_G_C
659 CCDC25_3 8_27736133_T_C / 8_27740525_GA_G / 8_27740655_A_G
660 PTGFRN_2 1_116949272_C_G / 1_116985006_T_C
661 CUEDC1_2 17_57872703_C_T / 17_57873465_G_A
662 POLR3D_5 8_22247989_T_C / 8_22247116_G_A / 8_22247770_T_C / 8_22250473_A_G / 8_22245170_T_G
663 MDN1_10 6_89661483_G_A / 6_89662267_C_T / 6_89680724_C_A / 6_89712908_G_C / 6_89728912_G_T / 6_89745710_T_C / 6_89819438_A_G / 6_89819440_C_G / 6_89819446_A_G / 6_89656810_T_C
664 ZNF407_5 18_74635526_T_C / 18_74881076_C_G / 18_74881080_A_C / 18_75064165_G_A / 18_74881141_G_A
665 C18orf21_2 18_35977490_T_C / 18_35973023_A_G
666 DNHD1_2 11_6566998_G_A / 11_6502909_T_C
667 KCNQ5_2 6_72622312_C_G / 6_73194868_A_C
668 USP7_3 16_8916969_T_TA / 16_8921401_T_C / 16_8919178_A_G
669 KRT19_2 17_41524128_T_G / 17_41524420_C_T
670 CHD4_2 12_6598281_A_C / 12_6596093_T_C
671 TRIO_5 5_14270972_A_C / 5_14380924_T_A / 5_14287139_AT_A / 5_14485052_GTTTT_G / 5_14304660_GA_G
672 NR2F6_3 19_17232488_A_G / 19_17240807_T_C / 19_17240813_T_C
673 HNRNPH1_2 5_179621204_T_C / 5_179614784_GAAAAA_G
674 POLDIP3_2 22_42585672_T_C / 22_42585502_A_C
675 CASKIN2_4 17_75501358_G_A / 17_75501713_T_C / 17_75503616_T_C / 17_75508335_T_C
676 ZNF557_3 19_7083618_A_G / 19_7083750_A_G / 19_7074861_G_A
677 BPTF_2 17_67825365_C_T / 17_67911547_C_G
678 UGGT2_3 13_95833163_A_G / 13_95853698_T_C / 13_95860933_T_C
679 FNDC3B_3 3_172362611_AT_A / 3_172328905_GT_G / 3_172286041_CTTTT_C
680 CLIP1_3 12_122328152_A_C / 12_122328157_C_T / 12_122328162_C_T
681 TNKS_6 8_9680125_G_A / 8_9720284_A_AT / 8_9720294_C_A / 8_9735571_A_C / 8_9751720_A_C / 8_9766458_A_C
682 NAA15_2 4_139349721_G_A / 4_139349435_AT_A
683 RANBP3_5 19_5928023_T_G / 19_5928174_T_C / 19_5915583_A_G / 19_5925847_A_C / 19_5978199_C_T
684 CCP110_6 16_19536035_A_G / 16_19536181_C_T / 16_19545945_C_T / 16_19541861_T_C / 16_19536052_C_A / 16_19548016_T_G
685 ANXA11_2 10_80166029_C_T / 10_80161797_T_C
686 PLEC_5 8_143935900_T_G / 8_143916360_A_G / 8_143918739_A_C / 8_143929244_A_C / 8_143934289_T_G
687 PDHB_5 3_58429863_C_A / 3_58427942_G_T / 3_58430808_C_T / 3_58431043_T_TTTA / 3_58431689_C_T
688 ABHD12_3 20_25307869_C_T / 20_25297964_G_A / 20_25301097_T_C
689 TRAPPC8_10 18_31858057_A_C / 18_31913653_A_G / 18_31900873_G_A / 18_31900876_C_A / 18_31867505_T_G / 18_31907633_T_A / 18_31846589_A_C / 18_31871211_T_A / 18_31901115_GT_G / 18_31858058_CT_C
690 NARF_2 17_82488071_A_G / 17_82485433_G_A
691 RPL9_3 4_39454772_G_A / 4_39458104_T_C / 4_39457622_A_G
692 SENP7_2 3_101347873_T_A / 3_101513249_C_A
693 HERC1_4 15_63666001_A_C / 15_63666004_T_C / 15_63754569_A_C / 15_63706823_T_C
694 DOCK11_2 X_118627539_A_C / X_118580020_T_G
695 KLF5_3 13_73063987_G_T / 13_73062772_A_AGTGT / 13_73063986_TG_T
696 FERMT1_2 20_6119441_A_G / 20_6076305_T_G
697 CGGBP1_2 3_88056114_A_C / 3_88058700_T_G
698 CEP85L_4 6_118511157_T_C / 6_118565452_T_C / 6_118565798_G_T / 6_118652790_A_G
699 TCF4_7 18_55585157_G_A / 18_55464257_C_A / 18_55463971_TGTGTGTGA_T / 18_55275657_A_G / 18_55403517_A_C / 18_55461237_G_T / 18_55234488_T_G
700 DQX1_2 2_74518953_C_T / 2_74519195_A_T
701 UBR5_3 8_102327653_A_C / 8_102288240_T_C / 8_102311353_A_G
702 UBR7_2 14_93227076_C_T / 14_93227060_C_A
703 PRDM15_6 21_41804523_A_G / 21_41857170_C_CT / 21_41878737_C_T / 21_41878845_C_CG / 21_41879218_C_A / 21_41860296_C_G
704 HPS4_3 22_26464303_G_C / 22_26466187_C_A / 22_26466246_T_C
705 KIF13A_2 6_17759921_G_T / 6_17779691_GA_G
706 SLC35B4_8 7_134294793_A_T / 7_134294800_C_T / 7_134294826_A_G / 7_134295043_T_C / 7_134296475_G_A / 7_134299375_A_G / 7_134300126_G_A / 7_134304791_A_G
707 L3MBTL2_6 22_41213686_C_T / 22_41221314_G_C / 22_41217184_C_T / 22_41217299_C_T / 22_41221156_T_TG / 22_41214238_A_G
708 RAI14_6 5_34810866_G_A / 5_34811689_T_C / 5_34812303_A_G / 5_34812384_A_G / 5_34814795_A_G / 5_34826376_A_C
709 ARHGEF10L_2 1_17632421_T_G / 1_17581112_C_T
710 WFS1_2 4_6300580_T_G / 4_6301666_T_G
711 TPP2_5 13_102645085_CT_C / 13_102649187_G_T / 13_102629949_C_G / 13_102634223_C_T / 13_102645085_CTT_C
712 DPY19L3_3 19_32480317_C_T / 19_32482171_C_T / 19_32457979_A_AT
713 SYNE1_13 6_152149487_A_G / 6_152310394_A_C / 6_152302141_A_G / 6_152350340_A_C / 6_152350418_A_G / 6_152350784_G_GA / 6_152350840_A_G / 6_152354719_A_G / 6_152373049_T_C / 6_152416413_T_G / 6_152352408_C_CT / 6_152326359_G_A / 6_152167902_T_G
714 BAIAP2L1_2 7_98312162_T_G / 7_98310492_T_G
715 CXXC1_4 18_50283881_C_G / 18_50283981_A_G / 18_50282775_A_C / 18_50285505_A_G
716 ITGB5_3 3_124769064_T_G / 3_124796789_C_T / 3_124809087_T_G
717 BRD4_2 19_15255220_T_G / 19_15264730_T_G
718 TUBGCP6_3 22_50218683_C_T / 22_50226183_A_G / 22_50216669_A_G
719 SH2D4A_2 8_19373444_G_GTA / 8_19373444_G_A
720 UPP1_3 7_48088999_G_A / 7_48108129_C_G / 7_48108147_T_G
721 WDR48_5 3_39068755_C_T / 3_39069649_C_A / 3_39066494_T_A / 3_39077046_G_A / 3_39052175_T_A
722 PDS5B_5 13_32741072_A_T / 13_32758091_C_T / 13_32675925_C_A / 13_32710010_G_T / 13_32652145_GT_G
723 AHNAK2_13 14_104948863_G_C / 14_104950348_C_G / 14_104952007_T_G / 14_104952054_C_T / 14_104954590_A_G / 14_104955559_A_C / 14_104949306_T_C / 14_104950948_C_T / 14_104946565_A_C / 14_104949318_G_C / 14_104953856_A_C / 14_104944923_A_G / 14_104945888_T_G
724 PSIP1_4 9_15469426_TA_T / 9_15472613_GA_G / 9_15478664_T_C / 9_15473904_C_CA
725 ANK3_2 10_60140286_C_G / 10_60140292_G_T
726 PLEK_3 2_68380987_A_C / 2_68388306_A_G / 2_68380161_C_G
727 HMGB1_2 13_30463652_C_G / 13_30465849_T_C
728 ACTN1_2 14_68890121_A_G / 14_68904620_A_G
729 FAM193A_2 4_2662705_A_G / 4_2659865_A_C
730 ALS2CL_3 3_46688267_C_G / 3_46671861_C_A / 3_46683906_C_A
731 SMARCA5_3 4_143521582_C_T / 4_143514027_G_A / 4_143513907_T_G
732 TMBIM1_4 2_218278506_G_A / 2_218278604_T_C / 2_218279426_G_A / 2_218282145_T_C
733 ZNF236_5 18_76959812_T_C / 18_76968158_T_C / 18_76968252_C_T / 18_76936580_G_T / 18_76968514_A_G
734 DMAP1_3 1_44213884_A_G / 1_44219323_T_C / 1_44214487_A_C
735 GIT2_2 12_109951210_A_C / 12_109952676_A_C
736 PBRM1_4 3_52642049_CA_C / 3_52642048_AC_A / 3_52642050_A_T / 3_52658412_CTT_C
737 SEMA4B_3 15_90230550_C_T / 15_90219735_T_G / 15_90223369_T_C
738 CDH1_2 16_68823310_T_G / 16_68810107_C_G
739 PAK4_3 19_39176740_T_C / 19_39178411_T_C / 19_39178960_A_ATG
740 KDM5A_2 12_310904_G_A / 12_323658_C_A
741 CHMP7_4 8_23249152_A_G / 8_23260130_T_C / 8_23260642_T_C / 8_23255149_C_T
742 FASTKD1_2 2_169557305_CA_C / 2_169557305_CAA_C
743 MRPL39_5 21_25587877_T_G / 21_25588774_T_C / 21_25594005_A_G / 21_25603938_A_G / 21_25607316_G_A
744 PON2_2 7_95406313_A_C / 7_95406317_T_C
745 ATP9A_2 20_51608625_A_C / 20_51627544_T_G
746 SYNE2_3 14_64189964_AT_A / 14_64022731_CT_C / 14_64122119_G_A
747 EXD2_2 14_69236592_C_T / 14_69236597_G_T
748 USP22_9 17_21002832_G_C / 17_21002938_C_T / 17_21002944_A_G / 17_21005012_T_C / 17_21018179_C_T / 17_21021210_G_A / 17_21021307_T_C / 17_21028347_G_T / 17_21043080_T_C
749 R3HDM1_2 2_135621624_GT_G / 2_135661361_A_C
750 LAIR1_2 19_54364274_T_C / 19_54364717_T_C
751 EVL_5 14_100126634_T_G / 14_100132827_G_A / 14_100126622_G_A / 14_100132645_T_G / 14_100135917_A_C
752 RNF123_2 3_49714152_C_T / 3_49700145_G_T
753 DNMT1_2 19_10162649_G_A / 19_10143809_G_C
754 BTBD16_4 10_122275013_G_T / 10_122275188_T_C / 10_122285973_C_T / 10_122291060_G_A
755 FUCA2_2 6_143504166_C_A / 6_143507227_A_G
756 PPIP5K2_3 5_103201499_T_G / 5_103201584_A_G / 5_103201656_T_C
757 TIMM44_3 19_7932571_A_G / 19_7932574_T_G / 19_7932577_T_G
758 MEX3C_2 18_51196847_C_T / 18_51196775_CGCCGCCGCG_C
759 MTUS1_3 8_17754377_G_A / 8_17755366_A_G / 8_17721812_A_C
760 CTSH_2 15_78922969_A_C / 15_78939184_A_AG
761 IL18_3 11_112150193_T_G / 11_112155193_G_C / 11_112155192_T_C
762 ZNF654_2 3_88139270_G_A / 3_88140191_T_C
763 ZNF589_6 3_48241161_TGCGC_T / 3_48241205_A_G / 3_48257949_T_C / 3_48268338_C_G / 3_48286239_T_C / 3_48286261_G_A
764 EPS15_6 1_51361249_T_C / 1_51405766_G_GACTC / 1_51440277_CTGTG_C / 1_51463832_TA_T / 1_51472751_T_G / 1_51461237_G_A
765 ZNF266_2 19_9413509_A_G / 19_9420011_TG_T
766 BCAM_2 19_44820881_G_A / 19_44811510_C_T
767 C3orf38_3 3_88150029_T_C / 3_88150035_T_TC / 3_88150148_T_C
768 ERICH1_8 8_659132_C_G / 8_657766_C_G / 8_658018_C_T / 8_666590_T_A / 8_673593_G_A / 8_715858_C_T / 8_659879_A_C / 8_659039_G_A
769 LSR_2 19_35267372_G_GGGA / 19_35267177_A_C
770 PIK3C3_3 18_41955191_C_G / 18_41955194_A_G / 18_42043978_A_G
771 TAF3_4 10_7824594_T_C / 10_8013652_G_C / 10_8013913_G_A / 10_8014532_C_T
772 FNBP1_2 9_129909080_T_TG / 9_129923982_A_G
773 SACM1L_14 3_45719623_G_C / 3_45722143_A_G / 3_45722754_A_G / 3_45723052_T_C / 3_45731250_T_C / 3_45731280_G_A / 3_45732240_G_A / 3_45737644_A_T / 3_45705344_A_G / 3_45706937_G_A / 3_45713257_G_A / 3_45712995_C_A / 3_45689454_T_G / 3_45739488_A_G
774 TXNL1_3 18_56602813_A_T / 18_56626612_C_T / 18_56651278_A_T
775 PTPN3_2 9_109436866_A_G / 9_109406452_T_G
776 LAMA3_9 18_23861753_C_T / 18_23915519_T_C / 18_23946123_C_T / 18_23949758_G_A / 18_23954737_C_A / 18_23954739_C_T / 18_23939340_A_C / 18_23713905_CT_C / 18_23846109_T_G
777 MTMR9_3 8_11284836_T_G / 8_11309724_G_A / 8_11322815_A_C
778 ITGA6_4 2_172427981_A_G / 2_172427985_C_T / 2_172484735_A_G / 2_172490965_G_T
779 KRI1_8 19_10557707_T_C / 19_10558277_G_A / 19_10560316_C_T / 19_10565667_A_T / 19_10565747_G_A / 19_10561817_C_T / 19_10562664_C_T / 19_10565811_G_GCC
780 GBP3_2 1_89007941_G_A / 1_89011034_A_T
781 FGFR2_2 10_121487530_T_C / 10_121520352_C_T
782 TNRC6C_2 17_78049826_A_C / 17_78067796_A_G
783 PDGFRB_2 5_150135511_G_A / 5_150129967_A_C
784 ASPH_2 8_61578734_T_G / 8_61638365_TA_T
785 MRPS25_2 3_15065217_A_C / 3_15065038_A_C
786 CNIH4_2 1_224356827_A_G / 1_224379302_G_A
787 STAT5B_2 17_42212246_T_A / 17_42218217_T_TG
788 NRF1_5 7_129690176_C_G / 7_129709261_G_A / 7_129710330_A_C / 7_129711604_C_G / 7_129717099_T_G
789 C21orf58_2 21_46302477_A_G / 21_46322980_A_AG
790 EBF1_2 5_159099526_TA_T / 5_159099526_T_TA
791 PCNT_10 21_46438359_T_C / 21_46440304_C_T / 21_46442711_A_G / 21_46444647_CTTT_C / 21_46444900_C_T / 21_46444910_G_C / 21_46355631_G_C / 21_46425893_A_C / 21_46444675_T_G / 21_46444677_T_G
792 RFT1_3 3_53104238_T_C / 3_53120116_ATTAACTGCAC_A / 3_53120127_T_G
793 NGLY1_4 3_25733865_A_C / 3_25736073_G_T / 3_25764388_T_C / 3_25732334_A_C
794 SHPRH_2 6_145955343_T_G / 6_145922945_GT_G
795 PSAP_4 10_71817510_G_A / 10_71820222_G_A / 10_71823763_G_C / 10_71825769_A_G
796 EPG5_4 18_45907942_A_G / 18_45860332_T_G / 18_45967161_TG_T / 18_45949582_G_A
797 GRB7_2 17_39746744_A_C / 17_39737973_T_C
798 TBC1D5_5 3_17233681_G_C / 3_17238034_T_C / 3_17258641_A_C / 3_17428395_ATG_A / 3_17238102_T_G
799 TTLL3_5 3_9825941_C_T / 3_9826893_A_G / 3_9829346_T_G / 3_9832986_G_A / 3_9835303_G_A
800 HAUS1_4 18_46118343_C_T / 18_46123257_C_G / 18_46122767_C_T / 18_46118217_A_T
801 FGD4_3 12_32640343_A_C / 12_32640545_A_C / 12_32582270_A_C
802 PPDPF_2 20_63522320_T_G / 20_63521771_A_C
803 ITGA2_2 5_53091493_C_T / 5_53042183_A_C
804 SLC44A3_5 1_94839884_A_G / 1_94865029_A_C / 1_94857210_T_G / 1_94857357_C_G / 1_94892383_G_T
805 USP4_5 3_49284594_T_A / 3_49305742_G_A / 3_49324936_C_T / 3_49335612_A_G / 3_49302213_T_A
806 CCDC12_4 3_46922012_T_C / 3_46923707_C_G / 3_46941247_T_C / 3_46923591_T_G
807 TRIOBP_4 22_37723206_G_A / 22_37734378_A_C / 22_37765828_T_TG / 22_37750578_C_T
808 RAF1_2 3_12603508_C_T / 3_12606048_T_TG
809 FMNL1_5 17_45241411_G_C / 17_45241412_C_G / 17_45243751_T_G / 17_45232440_T_G / 17_45244864_G_C
810 RIPK4_2 21_41746606_T_G / 21_41746170_T_C
811 AGPAT5_2 8_6724964_A_C / 8_6757085_A_G
812 USP48_3 1_21703696_T_C / 1_21706077_T_G / 1_21706735_G_A
813 AP1M1_8 19_16206608_T_TG / 19_16226612_T_C / 19_16227721_G_A / 19_16228258_G_A / 19_16228904_C_T / 19_16233717_C_G / 19_16234288_T_C / 19_16228794_T_G
814 DAZAP1_2 19_1432575_T_C / 19_1432578_A_C
815 PACSIN3_2 11_47180569_G_A / 11_47182508_A_C
816 R3HCC1_4 8_23288582_A_G / 8_23291465_G_T / 8_23293365_T_G / 8_23290051_G_A
817 SERPINB5_10 18_63486810_T_C / 18_63487155_C_T / 18_63489373_G_C / 18_63493054_T_C / 18_63493152_T_C / 18_63503267_T_C / 18_63503488_T_C / 18_63503549_A_G / 18_63503234_G_A / 18_63504446_A_T
818 U2AF1_2 21_43107500_A_C / 21_43107485_A_C
819 LLGL2_4 17_75569181_T_A / 17_75558442_C_G / 17_75573695_C_CCT / 17_75575074_T_C
820 PPFIA1_4 11_70365468_A_G / 11_70375250_G_T / 11_70337631_C_G / 11_70331778_TCAAAAA_T
821 STAG3_2 7_100197862_A_C / 7_100182660_G_A
822 MYO5B_13 18_49837561_G_C / 18_49875910_A_C / 18_49937217_A_G / 18_49954290_G_A / 18_49847096_G_A / 18_49849562_C_G / 18_49849733_C_G / 18_49880543_A_G / 18_49880568_T_C / 18_49929553_C_T / 18_49929610_GA_G / 18_49954528_T_C / 18_49962255_A_G
823 ZNF441_2 19_11767280_T_G / 19_11778532_C_T
824 FAM83H_3 8_143728128_T_G / 8_143725596_G_C / 8_143730455_T_G
825 KCNAB2_4 1_6085319_C_T / 1_6095272_T_C / 1_6085347_G_A / 1_6094357_C_T
826 MMP15_4 16_58038249_C_T / 16_58042518_A_G / 16_58045261_G_A / 16_58037634_A_C
827 PKNOX1_3 21_43028653_G_C / 21_43028665_G_A / 21_43029807_G_A
828 CNOT6L_3 4_77720488_T_G / 4_77720486_A_G / 4_77726534_A_C
829 C1orf109_4 1_37683521_C_T / 1_37689469_G_GGT / 1_37689593_G_C / 1_37684175_A_G
830 MAP7_2 6_136361034_G_A / 6_136411526_G_A
여기서, FRH는 발현 유전자를 나타내고, FRH에 부가되어 표시된 숫자는 각 발현 유전자에 연관된 마커의 개수를 의미한다.
용어의 설명
본 발명에서 약물타입(DrugClass)에 대한 정의는 약물 표적들의 타입(type) 및 약물의 관능기적 유사한 기능 타입, 혹은, 약물이 영향을 주는 범주의 유전자그룹, 약물 패스웨이(drug pathway) 혹은 약물 시그널링 패스웨이(drug signaling pathway), 등은 모두 하나의 통칭 약물타입(DrugClass)로 설명 하는 용어이다. FRH는 기능하프로타입(functionally related relative haplotype)을 나타내는 용어이고, eQTL은 발현에 대한 양적형질위치 (expression quantitative trait loci)을 나타내는 용어이며, FRH(Exp|IC50)는 과/저(over/under) 발현된 군집에 대한 IC50의 평균값을 나타내는 용어이고, FRH(CNV|IC50)는 증폭/삭제(amplification/deletion) 군집에 대한 IC50의 평균값을 나타내는 용어이며, FRH(loci|IC50)는 주어딘 loci타입 군집에 대한 IC50의 평균값을 나타내는 용어이고, GDSC는 Genomics of Drug Sensitivity in Cancer을 나타내는 용어이며, CCLP는 COSMIC Cell Lines Project을 나타내는 용어로 웹페이지 http://cancer.sanger.ac.uk/cell_lines로부터 확인할 수 있고, CNV는 복제수변이(Copy number variation)을 나타내는 용어이며, GBLscan는 암동반진단마커 스켄(Cancer Biomarker Labeling Scan)을 나타내는 용어이고, ISCT는 가상임상(In Silico Clinical Trial)을 나타내는 용어이다.
본 발명의 권리는 위에서 설명된 실시예에 한정되지 않고 청구범위에 기재된 바에 의해 정의되며, 본 발명의 분야에서 통상의 지식을 가진 자가 청구범위에 기재된 권리범위 내에서 다양한 변형과 개작을 할 수 있다는 것은 자명하다.
본 발명은 암을 포함하는 질병 관련 특이 유전자 변이 지문 (Genetic Variation Fingerprints)과 약물의 분자 약리관능기의 결합분석에 의해 약물의 반응성을 신뢰성 있게 예측할 수 있는 새로운 선형 회귀 모델인 약물 적응증 및 반응 예측 시스템 및 방법인 GBLscan (Genetic Biomarker Scan)에 관한 것으로, 본 발명에 의하면, 본 발명에서는 체외 및 체내 임상시험으로부터 수집되는 유전체에 대한 약물의 반응성 결과들로부터, 약리 효과가 밝혀지지 않은 유전체와 약물의 반응성 정도를 예측할 수 있는 효과가 있다.

Claims (9)

  1. EGFR 약물에 대한 반응성 판단을 위하여, 유전자 발현을 조절하는 변이가 포함된 마커들의 조합으로 구성되는 바이오 마커 조성물에 있어서,
    상기 바이오 마커 조성물은,
    9_111597344_C_A(마커1) 및 18_47115026_C_T(마커2)를 포함하여 구성됨을 특징으로 하는 EGFR 약물 반응성 판단을 위한 바이오 마커 조성물.
  2. 제 1 항에 있어서,
    상기 바이오 마커 조성물은,
    표 21에 기재된 마커들 중에서 어느 하나 이상의 마커를 더 포함하여 구성됨을 특징으로 하는 EGFR 약물 반응성 판단을 위한 바이오 마커 조성물.
  3. 제 1 항 또는 제 2 항에 있어서,
    상기 EGFR 약물은,
    Gefitinib, Erlotinib, Cetuiximab, Lapatinib, Afatinib, HG-5-88-01, CP724714 또는 Pelitinib 중 어느 하나 이상을 포함함을 특징으로 하는 EGFR 약물 반응성 판단을 위한 바이오 마커 조성물.
  4. EGFR 약물에 대한 반응성 판단을 위하여, 유전자 발현을 조절하는 변이가 포함된 마커들의 조합으로 구성되는 바이오 마커 조성물을 검출하여, EGFR 약물에 대한 반응성을 판단하는 방법에 있어서,
    상기 바이오 마커 조성물은,
    9_111597344_C_A(마커1) 및 18_47115026_C_T(마커2)를 포함하여 구성됨을 특징으로 하는 바이오 마커 조성물을 이용한 EGFR 약물 반응성 판단 방법.
  5. 제 4 항에 있어서,
    상기 바이오 마커 조성물은,
    표 21에 기재된 마커들 중에서 어느 하나 이상의 마커를 더 포함하여 구성됨을 특징으로 하는 바이오 마커 조성물을 이용한 EGFR 약물 반응성 판단 방법.
  6. 제 4 항 또는 제 5 항에 있어서,
    상기 EGFR 약물은,
    Gefitinib, Erlotinib, Cetuiximab, Lapatinib, Afatinib, HG-5-88-01, CP724714 또는 Pelitinib 중 어느 하나 이상을 포함함을 특징으로 하는 바이오 마커 조성물을 이용한 EGFR 약물 반응성 판단 방법.
  7. EGFR 약물에 대한 반응성 판단을 위하여, 유전자 발현을 조절하는 변이가 포함된 마커들의 조합으로 구성되는 바이오 마커 조성물을 검출하는 진단칩에 있어서,
    검출대상인, 상기 바이오 마커 조성물은,
    9_111597344_C_A(마커1) 및 18_47115026_C_T(마커2)를 포함하여 구성됨을 특징으로 하는 EGFR 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩.
  8. 제 7 항에 있어서,
    상기 바이오 마커 조성물은,
    표 21에 기재된 마커들 중에서 어느 하나 이상의 마커를 더 포함하여 구성됨을 특징으로 하는 EGFR 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩.
  9. 제 7 항 또는 제 8 항에 있어서,
    상기 EGFR 약물은,
    Gefitinib, Erlotinib, Cetuiximab, Lapatinib, Afatinib, HG-5-88-01, CP724714 또는 Pelitinib 중 어느 하나 이상을 포함함을 특징으로 하는 EGFR 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩.
KR1020190098569A 2018-10-18 2019-08-13 Egfr 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 egfr 약물 반응성 판단 방법 및 egfr 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 KR20200054857A (ko)

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KR20180124512 2018-10-18
KR1020180124512 2018-10-18
KR1020190096410A KR20200044677A (ko) 2018-10-18 2019-08-07 암 약물 반응성 판단을 위한 바이오 마커, 이를 이용한 암 약물 반응성 판단 방법 및 이를 위한 암 약물 반응성 진단칩
KR1020190096410 2019-08-07
KR1020190098165 2019-08-12
KR1020190098165A KR20200054058A (ko) 2018-10-18 2019-08-12 암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 암 약물 반응성 판단 방법 및 암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩

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KR1020190096410A KR20200044677A (ko) 2018-10-18 2019-08-07 암 약물 반응성 판단을 위한 바이오 마커, 이를 이용한 암 약물 반응성 판단 방법 및 이를 위한 암 약물 반응성 진단칩
KR1020190098165A KR20200054058A (ko) 2018-10-18 2019-08-12 암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 암 약물 반응성 판단 방법 및 암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
KR1020190098494A KR20200054060A (ko) 2018-10-18 2019-08-13 혈액암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 혈액암 약물 반응성 판단 방법 및 혈액암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
KR1020190098508A KR20200054855A (ko) 2018-10-18 2019-08-13 뇌종양 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 뇌종양 약물 반응성 판단 방법 및 뇌종양 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
KR1020190098492A KR20200054059A (ko) 2018-10-18 2019-08-13 암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 암 약물 반응성 판단 방법 및 암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
KR1020190098569A KR20200054857A (ko) 2018-10-18 2019-08-13 Egfr 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 egfr 약물 반응성 판단 방법 및 egfr 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
KR1020190098525A KR20200054856A (ko) 2018-10-18 2019-08-13 폐암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 폐암 약물 반응성 판단 방법 및 폐암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
KR1020210107667A KR20210103452A (ko) 2018-10-18 2021-08-13 혈액암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 혈액암 약물 반응성 판단 방법 및 혈액암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩

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KR1020190096410A KR20200044677A (ko) 2018-10-18 2019-08-07 암 약물 반응성 판단을 위한 바이오 마커, 이를 이용한 암 약물 반응성 판단 방법 및 이를 위한 암 약물 반응성 진단칩
KR1020190098165A KR20200054058A (ko) 2018-10-18 2019-08-12 암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 암 약물 반응성 판단 방법 및 암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
KR1020190098494A KR20200054060A (ko) 2018-10-18 2019-08-13 혈액암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 혈액암 약물 반응성 판단 방법 및 혈액암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
KR1020190098508A KR20200054855A (ko) 2018-10-18 2019-08-13 뇌종양 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 뇌종양 약물 반응성 판단 방법 및 뇌종양 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩
KR1020190098492A KR20200054059A (ko) 2018-10-18 2019-08-13 암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 암 약물 반응성 판단 방법 및 암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩

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KR1020210107667A KR20210103452A (ko) 2018-10-18 2021-08-13 혈액암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 혈액암 약물 반응성 판단 방법 및 혈액암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩

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