KR20200044680A - Chromatin 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 chromatin 약물 반응성 판단 방법 및 chromatin 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 - Google Patents
Chromatin 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 chromatin 약물 반응성 판단 방법 및 chromatin 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 Download PDFInfo
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Abstract
본 발명은 CHROMATIN약물 반응성 기능 정보를 포함하는 하플로타입(haplotype) 바이오마커를 예측하여, CHROMATIN 약물 반응성을 신뢰성 있게 예측 및 약 레이블링을 할 수 있게 하는 새로운 학습 모델인 GBLscan (Cancer Biomarker Labeling Scan)을 이용한 CHROMATIN 약물 반응성 판단을 위한 바이오 마커 조성물에 관한 것으로, 본 발명은 CHROMATIN 약물에 대한 반응성 판단을 위하여, 유전자 발현을 조절하는 변이가 포함된 마커들의 조합으로 구성되는 바이오 마커 조성물에 있어서, 상기 바이오 마커 조성물은, 2_72891611_A_C(마커1) 및 1_8013331_A_G(마커2)를 포함하여 구성된다. 이와 같은 본 발명에 의하면, 본 발명에서는 CHROMATIN 관련 약물들에 대한 바이오 마커들을 통해, CHROMATIN 약물에 대하여, 대상자 유전형질별 민감성을 예측할 수 있으므로, 개인별 맞춤의학 분야뿐만 아니라 신약 후보군 발굴에 효과적인 예비검증이 이루어지도록 하는 효과가 있다.
Description
본 발명은 CHROMATIN 암약물의 반응성을 예측하기 위한 유전자발현정보 및 복제수변이(CNV)를 이용한 기능 정보를 포함하는 하플로타입(haplotype) 바이오마커에 관한 것으로, CHROMATIN 약물 반응성을 신뢰성 있게 예측할 수 있도록 하는 CHROMATIN 약물 반응성 판단을 위한 바이오 마커 조성물에 관한 것이다.
최근에 차세대시퀀싱 (NGS, next generation sequencing) 기술의 혁신으로 복잡하고 다양한 암을 이해하는데 많은 발전이 이루어졌다. 또한, 국제적인 컨소시엄의 노력으로 이러한 암 종의 체세포 돌연변이에 대한 카탈로그뿐만 아니라 총체적인 암 유발 돌연변이(driver mutation) 데이터베이스도 개발 및 발표되었다[선행기술문헌 001 참조].
이러한 국제적인 컨소시엄 연구 성과로 인해서 개별 종양의 특정 유전체 지문(genomic fingerprint)에 대한 암 맞춤치료에 대한기대 또한 급속도로 커지게 되었다.
그러나 현재 암 환자 및 제약업계를 포함한 의료계의 모든 이해 관계자들에게 임상에서 승인되고 사용되는 새로운 맞춤 암 치료제는 여전히 충분하지 않은 실정이다[선행기술문헌 002 참조]. 따라서, 유전체정보와 항암제의 반응 사이의 개인 맞춤을 위한 연관성을 예측하기 위한 효율적이고 체계적인 접근이 필요하게 되었다.
그리고 암 세포주 및 약물 독성 데이터의 분자 프로파일링 데이터를 통합하기 위해 여러 가지 협력 컨소시엄이 이루어졌다[www.lincsproject.org, 선행기술문헌 003 참조]. 이러한 컨소시엄은 항암제 독성 및 개인에 특화된 맞춤 약물을 예측할 수 있는 유전체 바이오마커 (biomarker)를 밝히는 것이 가장 중요한 목표이다.
암에서의 약물 독성을 위한 세포주 유전체 DB중에서 GDSC (GDSC, Genomics of Drug Sensitivity in Cancer)는 공개적으로 이용 가능한 데이터베이스의 한 예이다. 특히, GDSC는 265개의 항암 화합물에 대하여 1,070 개의 인간 암세포의 약물 독성 정보를 실험적으로 측정한 공용 데이터베이스이다[선행기술문헌 004 참조].
여기서 사용된 GDSC의 세포주 프로젝트는 다음의 사이트에서 공개되었다 (CCLP: COSMIC Cell Lines Project, http://cancer.sanger.ac.uk/cell_lines). 이러한 공용 자원은 유전체 기반 정밀 암 치료제 실현에 큰 도움이 될것으로 기대된다.
그러나 이러한 데이터베이스의 잠재적인 가치에도 불구하고 높은 차원의 데이터와 복잡성으로 인해 통합 분석에는 많은 기술적인 문제가 존재한다. 따라서, 항암 약물 독성에서 분자 바이오마커를 체계적으로 규명하기 위한 많은 계산방법이 개발되었지만[선행기술문헌 003 참조], 이러한 노력에도 불구하고 약물 독성은 특정 세포주 및 주어진 유전자 변이 세트에 제한되는데, 이는 모든 사람의 유전정보는 모두 다르고, 공통적인 변이는 전체에서 일부분이기 때문이다.
정보 기술의 최근 발전으로 앞에서 언급한 복잡한 문제를 해결하기 위해 점점 더 많이 사용되는 방법이 딥러닝 모델(deep learning model) 또는 심층학습 모델이라 부른다[선행기술문헌 005 참조]. 딥러닝 학습 방법은 대량의 고차원 원시 데이터로부터 심층 기계 학습을 하는 기술의 한 분야이다.
최근까지는 학습을 하기에 계산 양의 한계로 직접적으로 많은 제한이 있었지만, 그러나 방법론적 개선과 병렬 컴퓨팅에 의한 강력한 기계를 사용하면서 수천 개의 숨겨진 유닛을 포함하는 다양한 레이어로 딥러닝 학습 모델을 교육할 수 있게 되었다[선행기술문헌 006 참조].
한편, 약리적, 유전체, 전사체 및 후성유전체 데이터와 그들의 약물반응성 데이터와 같은 여러 유형의 구조 정보를 조작할 수 있기 때문에 최소한의 지침으로 약물-표적 상호 작용 예측에 적합하게 되었다[선행기술문헌 005 참조].
제약 업계는 신약 개발을 위해 이러한 유형의 데이터를 활용하는 딥러닝 학습에 많은 기대감을 보여주기 시작했다. 최근에는 약물 개발에서 인공 지능을 사용하여 몇 가지 유망한 결과가 입증되었고[선행기술문헌 007 참조], 약물-표적 프로파일 및 다른 전통적인 기계 학습 모델에 비해 우수한 예측 정확도를 갖는 약물 재사용(drug repositioning)도 가능해졌다. 그러나 대다수의 접근방법은 오히려 개념 증명에 그쳤고, 딥러닝 학습을 통한 약물 발견의 생산 가능 솔루션은 부족한 현실이다.
현재 PubChem(pubchem.ncbi.nlm.nih.gov)은 미국 NCBI(국립기술정보센터)에서 운영하고 있고, 약 1억개 화합물(compounds), 2억 개의 물질(substances) 및 바이오에세이(bioassay)정보를 보유하고 있다(en.wikipedia.org/wiki/PubChem).
또한, 이러한 화합물(compound)은 약리적 작용기(pharmacophore descriptor)로 표현하는 많은 방법들이 존재한다[선행기술문헌 008 참조]. 그 중에서 파델(PaDELL) 방법은 약물에서 1,875 (1D 및 2D 1,444개, 그리고 3D 431개) 특징(feature) 및 12개의 지문(전체 약 16,092 비트)으로 표현할 수 있다[선행기술문헌 008 참조].
그리고 유전체에서 변이는 다양한 특징들을 추출할 수 있다. 특히, 질병원인 변이를 추출하는 종래의 방법들은 다양한 문헌에 개시된 바 있다.
따라서, 종래기술은 개별적으로 QSAR(Quantitative structureactivity relationship), 약물 세포독성 데이터를 사용한 약물개발, 딥러닝 (Deep Learning)기반 전장유전체(whole genome sequencing)의 발현조절, 구조적 변이 등이 독립적으로 적용되어 활용되었다.
그러나 본 발명에서는 약물(drugs)-세포(cell lines)-독성(IC50) 데이터에 이종 특성정보(유전체정보, QSAR정보 및 발현정보)를 통합한 AI 딥러닝 방법인 CDRscan(Cancer drug response scanning)은 예측 정확도가 이전 컴퓨터 모델링 접근법과 비교하여 현저히 향상되었고, 특히, 버추얼 약물(drugs) vs. 버추얼 세포(cell lines) 혹은 표적단백질의 상호작용 모델을 제안한 바 있다.
여기서, 2개의 다른 이종 특성 버추얼 정보는 첫 번째가 약물인 경우, 파델(PaDELL) 방법 혹은 선행기술문헌 029 내지 033에 개시된 방법 들이 적용될 수 있다.
그리고 두 번째는 전장 유전체(혹은 표적 단백질)의 지문(Genomic fingerprint, or a set of mutation features)에 대한 문헌방법으로 설명이 될 수 있고, 가장 표준적인 딥러닝 방법은 선행기술문헌 009에 개시된 바와 같다.
따라서 본 방법은 정확한 약물반응 예측모델 및 약물 재사용/재배치(drug repositioning), 화학 물질의 스크리닝 및 새로운 항암제 후보 발굴 및 환자 맞춤형 항암제 선택을 위한 임상의사결정지원시스템(Clinical decision supporting system) 에 사용될 수 있다.
그리고 최근에 재사용/재배치 (drug repositioning)관련 암약물반응스켄(CDRscan) 논문이 본사에 의하여 출판이 되었다[선행기술문헌 010 참조].
즉, 유전자발현 및 시스템적 통계적인 방식으로 주어진 약물 및 표적유전자 약 그리고 표적 후보유전자들의 발현정보 및 바이오마커 정보를 활용한 약물반응성 연구가 최근에 발표되었다.
본 논문에서는 바이오마커 자체에 대한 연구는 없었지만, 알려진 유전자 바이오마커 및 발현정보를 활용하여 주요표적에 대한 주요 약물 몇 개에 대하여 저해 능력(inhibition)을 CCLE(Cancer Cell Line Encyclopedia), CTRP(Cancer Therapeutics Response Portal, Broad) 및 일부 GDSC를 활용하여 예측(CARE)하고 검증하는 결과를 보여주었다[선행기술문헌 011 참조].
또한, eQTL (expression and Quantitative Trait Loci), 즉 발현과 유전체 변이간의 질병 혹은 표현형 연관관계에 대한 주요 연구가 많이 발표되었다[선행기술문헌 012 참조]. 그리고, pQTL (protein and Quantitative Trait Loci), 즉 단백질 생성과 유전체 변이간의 질병 혹은 표현형 연관관계에 대한 주요 연구 역시 많이 발표되었다[선행기술문헌 013 참조].
그러나 cQTL (Copy Number Variation and Quantitative Trait Loci), 즉 약물반응성 및 유전자 복제수 증가 혹은 감소 변이인 CNV(copy number variation)와 유전체 변이간의 약물반응 혹은 약물 표현형 연관관계에 대한 연구는 아직까지 발표된 적이 없다.
따라서, 본 GBLscan(genetic biomarker label scan)방법에서는 (a) eQTL (expression and Quantitative Trait Loci), 즉 발현과 유전체 변이간의 질병 혹은 표현형 연관관계, (b) cQTL (Copy Number Variation and Quantitative Trait Loci), 즉 유전자 복제 수 변이(copy amplification) 및 감소 (copy deletion)과의 연관관계는 아직 참고문헌이 존재하지 않는다.
본 발명에서 약물타입(DrugClass)에 대한 정의는 약물 표적들의 타입(type) 및 약물의 관능기적 유사한 기능 타입, 혹은, 약물이 영향을 주는 범주의 유전자그룹, 약물 패스웨이(drug pathway) 혹은 약물 시그널링 패스웨이(drug signaling pathway), 등은 모두 하나의 통칭 약물타입(DrugClass)로 설명을 한다. 또한, 기능하플로타입은 일반적으로 사용하는 하플로타입인 유전자에서 페이싱(phasing)이 된 여러개의 로커스 (locus)들에 대한 반수체(haplotype)과 달리, 본 발명에서는 인간유전체 버전인 Dec. 2013 (GRCh38/hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https ://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 를 기반으로 차세대 시퀀싱 리드(read) 데이터를 정렬을 하게 되면, 각 유전자 로커스에서 지노타입 형태로 정보가 읽히게 된다. 이러한 지노타입형태는 1:homo, 2:hetero 혹은 3: alt home형태로 표현 되는데, 그러한 지노타입의 모음을 상대 하프로타입 이라고 할 수 있다. 그리고 특정 로커스의 단일 혹은 조합으로 구성된 상대 하플로타입이 특정 유전자의 발현과 연관이 있다면 이것을 기능하프로타입이라고 본 발명에서 정의한다.
한편, 아래 첨부된 비 특허 선행기술 문헌을 주요 내용별로 구분하면, 비특허문헌,
(001 - 002)은 유전체 정보와 항암제의 반응 사이의 연관성 논문이고;
(003 - 004)은 암 유전체 약물독성 및 COSMIC 세포주 프로젝트 문헌이며;
(005 - 006)은 딥러닝 심층학습 모델의 약리학 및 유전체관련 논문이고;
(007)은 딥러닝 심층학습 모델의 신약 개발에 사용된 논문이고;
(008)은 약물 및 변이를 특징(feature)으로 표현하는 방법 및 논문이고;
(009 - 010)은 딥러닝 방법론 및 알고리즘에 대한 논문이고;
(011)은 약물 재창출 혹은 약물반응성 예측 논문이고,
(012 - 013)은 eQTL 및 pQTL 방법론 및 알고리즘에 대한 논문이다.
(001) Forbes, S. A., et al. COSMIC: somatic cancer genetics at high-resolution. Nucleic Acids Research. 45, 777-783 (2017).
(002) Williams SP, & McDermott U. The pursuit of therapeutic biomarkers with high-throughput cancer cell drug screens. Cell Chemical Biology. 24, 1066-1074 (2017).
(003) Barretina, J, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 483, 603-7 (2012).
(004) Yang, W., et al. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Research. 41, 955-961 (2013).
(005) Vanhaelen, Q., et al.. Design of efficient computational workflows for in silico drug repurposing. Drug Discovery Today. 22, 210-222 (2017).
(006) Dahl, G. E., Jaitly, N. & Salakhutdinov, R. Multi-task neural networks for QSAR predictions. arXiv:1406.1231 (2014).
(007) Baskin, I.I., Winkler, D. & Tetko, I.V. A renaissance of neural networks in drug discovery. Expert Opinion on Drug Discovery. 11, 785-95 (2016).
(008) Yap CW. PaDEL-Descriptor: An open source software to calculate molecular descriptors and fingerprints. Journal of Computational Chemistry. 32, 1466-1474(2011)
(009) Deep Learning: Yann Lecun, Y., Bengio, Y. & Hinton, G. Nature. 521, 436-444 (2015)
(010) Cancer Drug Response Profile scan (CDRscan): A Deep Learning Model That Predicts Drug Effectiveness from Cancer Genomic Signature: Yoosup Chang, Scientific Report,. 8857 (2018)
(011) Genome-scale signatures of gene interaction from compound screens predict clinical efficacy of targeted cancer therapies. Peng Jiang, et al., Cell Systems, 6,1-12 (2018)
(012) eQTL: Maud Fagny, et al., PNAS, E7841-E7850 (2017)
(013) pQTL: Jerome Carayol, et al., Nat Commun., 8:2084 (2017)
본 발명은 상기와 같은 종래의 문제점을 해결하기 위하여 안출된 것으로, 본 발명은 전술한 바와 같은 기술배경 및 사회적 요구에 따라, 암 약물의 반응성을 반응 대상 유전체의 유전특성 및 지문을 기능성 정보를 가진 하플로타입으로 변환하여 높은 정밀도의 약물 적응증 및 민감성 예측 시스템을 제공하기 위한 것으로, 본 발명의 구체적인 목적은, 공지된 비-임상용 세포주 유전체, 그것 들의 유전자 발현정보 및 유전자 복제수변이, 그리고 생체내 약물반응과 관련을 양적형질위치(QTL: quantitative trait loci)들의 모음(기능성 하플로타입) 정보기반 선형 회귀 모델링 및 딥러닝 기계학습을 신뢰성 있게 예측할 수 있는 예측 시스템을 제공하기 위한 것이다.
그리고 본 발명에서는 본 발명에 의한 GBLscan방법에 의해 유전자 RNA발현 및 복제수변이(CNV)와 상관관계가 높은 양적 형질 위치 (QTL)들을 수집하여 기능정보를 가진 다중변이기반 하플로타입을 생성하고 약물 민감성 및 반응성을 효과적으로 필터링하는 가상임상(In Silico Clinical Trial)을 위한 약물 반응성을 예측하는 방법을 제공하기 위한 것이다.
상기한 바와 같은 목적을 달성하기 위한 본 발명의 특징에 따르면, 본 발명은 검사 대상 양적형질 위치(QTL)들의 위치 모음 생성하는 단계와; 기능 하플로타입(FRH)과 약물반응 상관관계 계산하는 단계와; 그리고, 기능 하플로타입기반 약물반응 예측모델 생성하는 단계로 구성된다.
우선, 양적형질 위치 (QTL)들의 위치 모음 생성하기 위한 제1단계에서는; 기능 연관 하플로타입(FRH)과 약물반응성 상관관계 계산을 수행하기 위하여, (A) 약 1,000개의 세포주에서 약 4백만 변이와 약 20,000 유전자 발현 상관관계 계산하고, 그리고, (B) 약물(265개)과 1,000개 셀라인 유전체의 각 20,000여개 유전자발현 및 유전자 복제수변이 들과의 상관관계 계산한다.
이때, (A)단계 및 (B)단계는 공통 변수로 유전자 발현 및 유전자 복제수변이들을 모두 포함하는데, 이러한 공통변수인 유전자발현 정보를 활용하여 약물반응에 영향을 주는, 다중 혹은 단일변이와 연관을 가진 변이를 수집한다. 이것을 양적형질 위치 (QTL)들의 위치 모음이라고 한다.
그리고 유전체통합 DB에서 각 세포주 유전체에서 단일 및 다중변이정보를 수집하여 기능 하플로타입을 만들고 동일 세포주에서 약물반응성 정보와 함께 추출하고, 이러한 기능 하플로타입 들을 기능 하플로타입, FRH(Functionally relevant haplotope)으로 정의하고, FRH를 해시넘버 (hash number)로 표현 한다.
그리고 제2단계에서는, 기능하플로타입(FRH)과 약물반응 상관관계 계산하기 위하여, 하플로타입(FRH)를 해시넘버(hash number)로 변한하고, 변환된 해시넘버를 사용하여 약물반응성정보와 조합 상관관계 테스트(Pairwise Pearson Test)를 수행하고, 이를 모든 암 종에서 위의 작업을 반복 한다.
기능하플로타입기반 약물반응 예측모델 생성하는 제3단계에서는, 특정 암에서 약물 패스웨이(drug pathway)기반 약물반응 예측모델 생성관련 과정을 다음과 같이 수행한다.
(1) 기능연관 하플로타입과 특정 암 및 특정약물 패스웨이(Drug Pathway)와 관련된 각 약물과 상관관계를 계산하고, (2) 기능하플로타입 및 약물반응성 상관관계 메트릭스에서 X축 및 Y축의 상관관계 정보를 클러스터링을 하며, (3) 각 예측모델에서 유의성(p-value)이 높은 것을 수집하여 모델에 상호작용 기능을 모델에 적용하여 선형 회귀 모델을 계산한다, 그리고, 마지막으로 (4) NGS 데이터를 입력으로 하여 약물반응성과 연관을 가진 기능하플로타입를 계산하고 선형 회귀 모델을 사용하여 약물반응성을 예측한다.
그리고 본 발명은, 전술한 바와 같은 기능 하플로타입 정보를 활용하여 약물반응성 예측 모델을 계산하기 위해, 검사 대상 유전체로부터 수집된 염기서열에서 다수의 변이들을 활용하여 기능 하플로타입 들을 계산하는 단계와: 선형 회귀 모델의 해를 계산하는 단계와; 이러한 해를 이용하여 암약물 중에 민감성이 높은 암 약물을 선별하는 시스템을 포함한다.
한편, 본 발명의 다양한 실시예 중 일 실시예를 설명하면, 본 발명은 (A) 약물반응에 영향을 미치는 변이들에 대한 양적형질위치(QTL)들의 위치모음을 산출하는 단계와; (B) 상기 양적형질위치(QTL)에 포함된 변이에 대한 기능하플로타입을 생성하는 단계와; (C) 상기 기능하플로타입을 기반으로 변이와 약물반응 상관관계 계산하는 단계; 그리고 (D) 상기 기능하플로타입을 기반으로 약물반응성을 예측하는 단계를 포함하여 수행될 수 있다.
이때, 상기 제(A)단계의 양적형질위치(QTL)들의 위치모음을 산출은, (A1) 복수의 세포주로부터 변이들과 유전자 RNA 발현의 상관관계를 도출하는 단계와; (A2) 약물들과 복수의 셀라인 유전체에 포함된 유전자 RNA발현 및 유전자 복제수변이(CNV)들과의 상관관계 도출하는 단계와; (A3) 상기 제(A1)단계 및 제(A2)단계에서 공통 적으로 상관관계에 영향을 미치는 유전자 RNA 발현 또는 유전자 복제수변이에 대한 유전자 발현 정보를 산출하는 단계; 그리고 (A4) 상기 유전자 발현정보에 관여된 단일 또는 다중 변이를 산출하여, 약물반응에 영향을 미치는 변이들에 대한 양적형질위치(QTL)를 산출하는 단계를 포함하여 수행되는 양적형질위치(QTL)들의 위치모음 생성 단계를 포함하여 수행될 수 있다.
그리고 상기 제(B)단계의 기능하플로타입의 생성은, 유전체통합DB로부터 양적형질위치(QTL)에 포함된 단일 또는 다중변이에 대한 하플로타입을 약물반응성과 함께 추출하여 생성될 수도 있다.
또한, 상기 기능하플로타입은, 유전자 RNA발현(Exp)과 약물반응성과의 상관관계 정보와; 유전자 다중변이(loci)와 약물반응성과의 상관관계 정보를 포함하여 구성될 수도 있다.
한편, 상기 기능하플로타입은, 유전자 복제수변이(CNV)와 약물반응성과의 상관관계 정보와; 유전자 다중변이(loci)와 약물반응성과의 상관관계 정보를 포함하여 구성될 수도 있다.
여기서 상기 유전자 다중변이(loci)는, 양적형질위치(QTL)기반으로 선별된 로커스(locus)들의 모음일 수도 있다.
그리고 상기 유전체통합DB는, 지노타입(Genotype)으로 구성된 셀라인(Cell Lines) 통합 DB일 수도 있다.
또한, 상기 약물 반응성은, ln Ic50 값으로 표현될 수도 있다.
그리고 상기 유전자 RNA발현은, 과발현(over-expression), 변화없음(normal) 및 저발현(under-exprfession)으로 구분될 수도 있다.
또한, 상기 복제수변이(CNV)는, 증폭(amplification), 변화없음(normal) 및 감소(deletion)로 구분될 수도 있다.
한편, 상기 제(C)단계의 상관관계 계산은, (C1) 유전자 다중변이(loci)와 연관된 유전자 RNA발현(Exp)를 판별하는 단계와; (C2) 상기 기능하플로타입으로부터 상기 유전자 RNA발현(Exp)에 대한 약물반응성을 산출하여 상기 유전자 다중변이(loci)에 대한 약물반응성을 판별하는 단계; 그리고 (C3) 상기 기능하플로타입에 포함된 유전자 다중변이(loci)와 약물반응성과의 상관관계 정보로부터 산출된 약물반응성과 상기 제(C2)단계에서 판별된 약물반응성을 비교하여 검증하는 단계를 포함하여 수행될 수도 있다.
그리고 상기 제(C1)단계의 연관은, 상기 유전자 다중변이(loci)가 포함된 세포주 및 상기 세포주에 포함된 유전자 RNA발현(Exp)정보를 판별함에 의해 수행될 수도 있다.
또한, 상기 제(D)단계의 약물반응성을 예측은, 유전자 RNA발현 차이에 대한 약물반응의 차이가 과발현보다 저발현이 큰 경우, 유전자 RNA의 저발현이 약물반응에 민감한 것으로 판단하고; 유전자 RNA발현 차이에 대한 약물반응의 차이가 과발현보다 저발현이 작은 경우, 유전자 RNA의 과발현이 약물반응에 민감한 것으로 판단할 수도 있다.
그리고 상기 제(D)단계의 약물반응성을 예측은, 과발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값이 저발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값보다 크면, 유전자 RNA의 과발현이 유전자 다중변이(loci)타입과 연관된 것으로 판별하고; 과발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값이 저발현 집단의 유전자 RNA발현 차이에 대한 약물반응 절대값 민감도 최고치의 차이값보다 작으면, 유전자 RNA의 저발현이 유전자 다중변이(loci)타입과 연관된 것으로 판별할 수도 있다.
한편, 상기 기능하플로타입은, 해시넘버 (hash number)로 표현될 수도 있다.
그리고 상기 기능하플로타입과 약물반응의 상관관계는, 해시넘버를 이용하여, 약물반응성정보와 조합상관관계 테스트(Pairwise Pearson Test)를 수행함에 의해 산출될 수도 있다.
한편, 본 발명은 전술한 바와 같은 방법으로 기능하플로타입을 생성하는 약물반응성, 유전자발현정보 및 복제수 변이를 이용한 기능하플로타이핑 시스템을 포함한다.
이때, 상기 기능하플로타입은, 약물에 대한 반응성 진단, 약물에 대한 환자군을 선별하는 동반진단을 위한 바이오마커 발굴, 약물표적발굴 또는 약물에 대한 가상임상에 사용될 수도 있다.
위에서 살핀 바와 같은 본 발명에 의한 가상임상을 위한 CHROMATIN 약물반응성에 관한 본 발명에서는 다음과 같은 효과를 기대할 수 있다.
즉, 본 발명에서는 CHROMATIN 타입의 약물들에 대한 바이오 마커들을 통해, CHROMATIN 약물에 대하여, 대상자 유전형질별 민감성을 예측할 수 있으므로, 개인별 맞춤의학 분야뿐만 아니라 신약 후보군 발굴에 효과적인 예비검증이 이루어지도록 하는 효과가 있다.
그리고 본 발명에서는 체내(in vivo), 체외(in vitro) 혹은 유전정보에 대한 알려진 약물의 반응성 결과들로부터, 약리 효과가 밝혀지지 않은 약물의 반응성 정도를 예측할 수 있는 효과가 있다.
또한, 본 발명은 유전체의 변이정보에 대한 약물을 구성하는 약리 관능기의 반응성 상관관계를 도출할 수 있으므로, 분석대상인 유전체의 변이 및 약물의 약리 관능기를 추출하면, 해당 유전체에 대한 약물의 반응성 정도를 신뢰성 있게 예측할 수 있는 효과가 있다.
그리고 본 발명은 유전체의 변이 특성정보에 대한 약물타입의 반응성 상관관계를 도출할 수 있으므로, 분석대상인 유전체의 변이에 대한 특성정보 및 약물타입정보를 알면, 해당 유전체에 대한 약물의 반응성 정도를 신뢰성 있게 예측할 수 있는 효과가 있다.
이를 통해 본 발명은, 미지의 고분자화합물(약물 개발 대상 물질)의 특정 유전체를 포함하는 세포주 혹은 인체에 대한 반응성을 임상시험 전에 예측할 수 있으므로, 신약 개발에 따른 시간 및 비용을 현저하게 줄일 수 있는 효과가 있으며, 이미 개발된 약물에 대하여도, 임상에서 밝혀진 유전체 이외의 다른 유전체에 대한 반응성 정도를 미리 예측할 수 있으므로 기존 약물에 대한 다른 용도의 발견 및 부작용 발견에 대한 연구 비용 및 시간을 현저히 줄여주는 효과가 있다.
도 1은 본 발명에 의한 약물반응예측을 위한 양적 형질 위치(QTL), 유전복제수변이 및 RNA발현예를 도시한 예시도.
도 2는 본 발명에 의한 유전적 바이오마커를 활용한 약물반응성 계산 스키마를 도시한 예시도.
도 3은 본 발명에 의한 유방암의 유전적 바이오마커와 약물반응성의 관계를 도시한 예시도.
도 4는 본 발명에 의한 NGS입력과 약물반응 및 RNA발현 네트워크를 도시한 예시도.
도 5는 본 발명에 의한 세포주 약물반응 값(IC50)과 기능하플로타입의 상관관계를 도시한 예시도.
도 6은 본 발명에 의한 양적형질 위치(QTL)와 약물반응 상관관계를 도시한 예시도.
도 7은 본 발명에 의한 변이, RNA발현, 유전자복제수변이 및 약물반응 네트워크를 도시한 예시도.
도 8은 본 발명에 의한 변이와 상관관계 세포주, 암, 약물반응, RNA발현 및 CNV증폭 예를 도시한 예시도.
도 9는 본 발명에 의한 기능하플로타입과 약물반응성 상관관계 계산 스키마를 도시한 예시도.
도 10은 본 발명에 의한 기능하플로타입와 약물반응성 네트워크를 도시한 예시도.
도 11은 본 발명에 의한 기능하플로타입과 유전자발현 및 유전자복제수변이 예를 도시한 예시도.
도 12는 본 발명에 의한 기능하플로타입 정의를 도시한 예시도.
도 13은 본 발명에 의한 FRH 방법과 유전자 발현과 약물 반응성 예측 예를 도시한 예시도.
도 14는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.0인 실시예를 도시한 예시도.
도 15는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.5인 실시예를 도시한 예시도.
도 16은 본 발명에 의한 기능하플로타입과 유전자발현 실시 예를 도시한 예시도.
도 17은 본 발명에 의한 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델 생성예를 도시한 예시도.
도 18은 본 발명에 의한 기능하플로타입과 약물반응성 연관관계 R^2를 도시한 예시도.
도 19는 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH의 실시예를 도시한 예시도.
도 20은 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH를 사용한 예측 모델의 일 실시예를 도시한 예시도.
도 21은 본 발명에 의한 FRH를 사용한 혈액암의 약물반응성 예측의 일 실시예를 도시한 예시도.
도 22는 본 발명에 의한 FRH를 사용한 활용가능 시스템의 일 예를 도시한 예시도.
도 23은 본 발명에 의한 FRH 바이오마커를 이용하여 암 및 약물 동반진단 칩을 제작하는 방법의 일 예를 도시한 예시도.
도 24는 본 발명에 의한 바이오마커 표현구조의 구성을 설명하는 예시도.
도 25는 주요 바이오마커들의 혈액암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 26은 주요 바이오마커들에 의해 발현된 유전자들과 혈액암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 27은 주요 바이오마커들의 여성암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 28은 주요 바이오마커들에 의해 발현된 유전자들과 여성암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 29는 주요 바이오마커들의 뇌종양 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 30은 주요 바이오마커들에 의해 발현된 유전자들과 뇌종양 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 31은 주요 바이오마커들의 두경부암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 32는 주요 바이오마커들에 의해 발현된 유전자들과 두경부암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 33은 주요 바이오마커들의 폐암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 34는 주요 바이오마커들에 의해 발현된 유전자들과 폐암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 35는 주요 바이오마커들의 육종암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 36은 주요 바이오마커들에 의해 발현된 유전자들과 육종암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 37은 주요 바이오마커들에 대한 ABL 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 38은 주요 바이오마커들에 대한 CHROMATIN 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 39는 주요 바이오마커들에 대한 EGFR 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 40은 주요 바이오마커들에 대한 ERK_MAPK 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 41은 주요 바이오마커들에 대한 IGFR 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 42는 주요 바이오마커들에 대한 MITOSIS 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 2는 본 발명에 의한 유전적 바이오마커를 활용한 약물반응성 계산 스키마를 도시한 예시도.
도 3은 본 발명에 의한 유방암의 유전적 바이오마커와 약물반응성의 관계를 도시한 예시도.
도 4는 본 발명에 의한 NGS입력과 약물반응 및 RNA발현 네트워크를 도시한 예시도.
도 5는 본 발명에 의한 세포주 약물반응 값(IC50)과 기능하플로타입의 상관관계를 도시한 예시도.
도 6은 본 발명에 의한 양적형질 위치(QTL)와 약물반응 상관관계를 도시한 예시도.
도 7은 본 발명에 의한 변이, RNA발현, 유전자복제수변이 및 약물반응 네트워크를 도시한 예시도.
도 8은 본 발명에 의한 변이와 상관관계 세포주, 암, 약물반응, RNA발현 및 CNV증폭 예를 도시한 예시도.
도 9는 본 발명에 의한 기능하플로타입과 약물반응성 상관관계 계산 스키마를 도시한 예시도.
도 10은 본 발명에 의한 기능하플로타입와 약물반응성 네트워크를 도시한 예시도.
도 11은 본 발명에 의한 기능하플로타입과 유전자발현 및 유전자복제수변이 예를 도시한 예시도.
도 12는 본 발명에 의한 기능하플로타입 정의를 도시한 예시도.
도 13은 본 발명에 의한 FRH 방법과 유전자 발현과 약물 반응성 예측 예를 도시한 예시도.
도 14는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.0인 실시예를 도시한 예시도.
도 15는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.5인 실시예를 도시한 예시도.
도 16은 본 발명에 의한 기능하플로타입과 유전자발현 실시 예를 도시한 예시도.
도 17은 본 발명에 의한 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델 생성예를 도시한 예시도.
도 18은 본 발명에 의한 기능하플로타입과 약물반응성 연관관계 R^2를 도시한 예시도.
도 19는 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH의 실시예를 도시한 예시도.
도 20은 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH를 사용한 예측 모델의 일 실시예를 도시한 예시도.
도 21은 본 발명에 의한 FRH를 사용한 혈액암의 약물반응성 예측의 일 실시예를 도시한 예시도.
도 22는 본 발명에 의한 FRH를 사용한 활용가능 시스템의 일 예를 도시한 예시도.
도 23은 본 발명에 의한 FRH 바이오마커를 이용하여 암 및 약물 동반진단 칩을 제작하는 방법의 일 예를 도시한 예시도.
도 24는 본 발명에 의한 바이오마커 표현구조의 구성을 설명하는 예시도.
도 25는 주요 바이오마커들의 혈액암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 26은 주요 바이오마커들에 의해 발현된 유전자들과 혈액암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 27은 주요 바이오마커들의 여성암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 28은 주요 바이오마커들에 의해 발현된 유전자들과 여성암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 29는 주요 바이오마커들의 뇌종양 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 30은 주요 바이오마커들에 의해 발현된 유전자들과 뇌종양 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 31은 주요 바이오마커들의 두경부암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 32는 주요 바이오마커들에 의해 발현된 유전자들과 두경부암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 33은 주요 바이오마커들의 폐암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 34는 주요 바이오마커들에 의해 발현된 유전자들과 폐암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 35는 주요 바이오마커들의 육종암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 36은 주요 바이오마커들에 의해 발현된 유전자들과 육종암 약물들에 대한 상관도(P-vlaue)값들을 표시한 그래프.
도 37은 주요 바이오마커들에 대한 ABL 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 38은 주요 바이오마커들에 대한 CHROMATIN 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 39는 주요 바이오마커들에 대한 EGFR 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 40은 주요 바이오마커들에 대한 ERK_MAPK 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 41은 주요 바이오마커들에 대한 IGFR 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
도 42는 주요 바이오마커들에 대한 MITOSIS 약물들의 상관도(P-vlaue)값들을 표시한 그래프.
이하에서는 첨부된 도면을 참조하여 본 발명의 구체적인 실시예에 의한 가상임상을 위한 암약물반응성, 연계된 유전자발현정보 및 복제수 변이를 이용한 기능 하플로타이핑 시스템 및 방법을 살펴보기로 한다.
설명에 앞서 먼저, 본 발명의 효과, 특징 및 이를 달성하는 방법은 첨부되는 도면과 함께 상세하게 후술되어 있는 실시 예에서 명확해진다. 그러나 본 발명은 이하에서 개시되는 실시 예들에 한정되는 것이 아니라 서로 다른 다양한 형태로 구현될 수 있으며, 단지 본 실시 예들은 본 발명의 개시가 완전하도록 하고, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자에게 발명의 범주를 완전하게 알려주기 위해 제공되는 것이며, 본 발명은 청구항의 범주에 의해 정의될 뿐이다.
본 발명의 실시 예들을 설명함에 있어서 공지 기능 또는 구성에 대한 구체적인 설명이 본 발명의 요지를 불필요하게 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명을 생략할 것이며, 후술되는 용어들은 본 발명의 실시 예에서의 기능을 고려하여 정의된 용어들로서 이는 사용자, 운용자의 의도 또는 관례 등에 따라 달라질 수 있다. 그러므로 그 정의는 본 명세서 전반에 걸친 내용을 토대로 내려져야 할 것이다.
도 1은 본 발명에 의한 약물반응예측을 위한 양적 형질 위치(QTL), 유전복제수변이 및 RNA발현예를 도시한 예시도이고, 도 2는 본 발명에 의한 유전적 바이오마커를 활용한 약물반응성 계산 스키마를 도시한 예시도이며, 도 3은 본 발명에 의한 유방암의 유전적 바이오마커와 약물반응성의 관계를 도시한 예시도이고, 도 4는 본 발명에 의한 NGS입력과 약물반응 및 RNA발현 네트워크를 도시한 예시도이며, 도 5는 본 발명에 의한 세포주 약물반응 값(IC50)과 기능하플로타입의 상관관계를 도시한 예시도이고, 도 6은 본 발명에 의한 양적형질 위치(QTL)와 약물반응 상관관계를 도시한 예시도이며, 도 7은 본 발명에 의한 변이, RNA발현, 유전자복제수변이 및 약물반응 네트워크를 도시한 예시도이고, 도 8은 본 발명에 의한 변이와 상관관계 세포주, 암, 약물반응, RNA발현 및 CNV증폭 예를 도시한 예시도이며, 도 9는 본 발명에 의한 기능하플로타입과 약물반응성 상관관계 계산 스키마를 도시한 예시도이고, 도 10은 본 발명에 의한 기능하플로타입와 약물반응성 네트워크를 도시한 예시도이며, 도 11은 본 발명에 의한 기능하플로타입과 유전자발현 및 유전자복제수변이 예를 도시한 예시도이고, 도 12는 본 발명에 의한 기능하플로타입 정의를 도시한 예시도이며, 도 13은 본 발명에 의한 FRH 방법과 유전자 발현과 약물 반응성 예측 예를 도시한 예시도이고, 도 14는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.0인 실시예를 도시한 예시도이며, 도 15는 본 발명에 의한 FRH의 일 예시로 평균 IC50 값의 차이가 1.5인 실시예를 도시한 예시도이고, 도 16은 본 발명에 의한 기능하플로타입과 유전자발현 실시 예를 도시한 예시도이며, 도 17은 본 발명에 의한 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델 생성예를 도시한 예시도이고, 도 18은 본 발명에 의한 기능하플로타입과 약물반응성 연관관계 R^2를 도시한 예시도이며, 도 19는 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH의 실시예를 도시한 예시도이고, 도 20은 도 18에 도시된 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH를 사용한 예측 모델의 일 실시예를 도시한 예시도이며, 도 21은 본 발명에 의한 FRH를 사용한 혈액암의 약물반응성 예측의 일 실시예를 도시한 예시도이고, 도 22는 본 발명에 의한 FRH를 사용한 활용가능 시스템의 일 예를 도시한 예시도이며, 도 23은 본 발명에 의한 FRH 바이오마커를 이용하여 암 및 약물 동반진단 칩을 제작하는 방법의 일 예를 도시한 예시도이고, 도 24는 본 발명에 의한 바이오마커 표현구조의 구성을 설명하는 예시도이다.
본 발명은 기본적으로, (A) 암 환자에게서 임상적으로 추출하기 어려운 유전자 RNA 발현정보 및 복제수변이 정보를 양적형질 위치(QTL)를 선행 계산하고, (B) 비임상 세포주 DB(GDSC 및 CCLE)와 같은 공용 데이터를 이용하여 유전자 RNA 발현정보 및 복제수변이 정보와 약물반응성 상관관계 실험 정보를 확보한 후, 상기 제(A)단계 및 제(B)단계를 통합하여 양적형질 위치(QTL)와 암약물반응 상관성을 계산하여 예측모델을 생성한다.
그리고 암 환자에게서 획득될 수 있는 유전체 정보를 기반으로 기능정보를 포함한 하플로타입을 계산하여 암환자의 약물반응성정보를 예측한다.
도 1에는 약물반응예측을 위한 양적 형질 위치(QTL), 유전복제수변이 및 RNA발현 예가 도시되어 있다. 즉, ①의 eQTL 실험 예문에서는, 변이와 발현의 직접(cis) 및 간접(trans)방식에 의해 조절되는 것이 나타나있고, ②의 Drug-Gene Expression은 약물과 RNA 발현의 상관관계를 보여준다. 그리고 ③의 Drug Cell viabillity는 약물의 농도와 세포의 활성관계를 보여주고, ④의 Drug-CNV는 약물의 농도와 유전자 복제수 변이(CNV)와의 상관관계를 보여준다. 그리고 ⑤의 Expression-CNV는 유전자 발현과 복제수 변이(CNV)와 상관관계를 보여준다.
즉, 도 1은 약물의 농도와 RNA 발현 및 유전자복제수변이(CNV)가 서로 상관관계를 가지고 있다는 것을 보여주고, 또한, 많은 경우에 RNA발현 및 유전자복제수변이(CNV)는 그것의 원인이 되는 단일 및 다중 변이와의 상관관계가 있음을 보여준다.
도 2에는 유전적 바이오마커를 활용한 약물반응성 계산 스키마에 있어, 대부분의 알려진 활성 약물이 약물에 민감한 군과 약물에 저항성을 주는 군으로 나누어지고, 이때, 민감성 및 저항성은 유전적 바이오마커와 밀접하게 연결되어 있다.
여기서, 유전적 바이오마커는 생식 및 체세포 변이, 드라이버변이, 복제수변이, 기능 하플로타입 변이, 후성 변이인 methylation 및 유전자 발현 등으로 구성된다.
그리고, 도 3에는 유방암의 유전적 바이오마커와 약물반응성의 관계의 일예가 도시되어 있다. 유전적바이오마커들의 메커니즘을 나타내는 A) 계략도에서 Her2 유전자가 과발현되어 있을 때, 세포표면 수용체를 표적으로 하는 약물인 tratuzumab와 세포 내부의 cytoplasm에서의 길항제를 표적으로 하는 lapatinib 및 두 개의 바이오마커 PI3CA와 PTEN의 위치가 나타나 있다. B) 그래프에는 tratuzumab 및 lapatinib의 경우 wild type과 PI3CA가 변이를 가진 경우와, PTEN까지 기능을 못하는 경우에 대하여 약물반응성이 계산된 결과가 나타나 있고, 약물 pathway 메카니즘에서 약물표적의 위치에 따라 바이오마커의 변이가 1개 및 2개에 대한 약물반응성이 달라짐이 도시되어 있다.
한편, 도 4에는 NGS 입력과 약물반응 및 RNA발현 네트워크의 일 예가 도시되어 있다.
NGS 입력과 약물반응 및 RNA발현 네트워크의 기본 구조는, A) NGS 입력데이터로부터 선행으로 계산된 양적형질 위치(QTL)기반 유전자 RNA 과발현/저발현 및 유전자 복제수 변이의 증폭/감소를 예측하고, B) 비임상(in vitro) 공용 약물 반응성 데이터와 유전자발현 데이터와 상관관계 정보를 이용하여, C) 임상(in vivo)에서 양적형질 위치(QTL)기반 약물반응을 예측한다.
본 발명은 A) 양적형질 위치(QTL) 정보를 확보하고, B) 유전자 RNA 발현정보와 약물반응성 실험데이터를 라이브러리(DB)화하고, C) 약물반응성을 예측하는 과정으로 설명될 수 있다. 이는 일반적으로 환자에 대하여 B) 단계의 약물반응정보 및 유전자발현 정보를 짧은 시간에 확보하기가 어럽거나 일부는 거의 불가하기 때문이다.
따라서, 도 1 내지 도 4는 환자로부터는 유전체정보 및 RNA발현정보 기반 양적형질 위치(QTL) 정보와 관련을 가진 단일 및 다중 변이정보를 확보하고, 공용 약물반응성 정보인 비임상(in vitro) 세포주 실험 정보와 연결을 만들고, 임상(in vivo)에서 환자에게 적용하는 방식이다.
도 5는 세포주 약물반응 값(IC50)과 기능하플로타입의 상관관계 예시도로, 도 5에는 최종적으로 세포주들과 약물반응성 정보 및 기능하플로타입의 상관관계를 Pearson 상관관계로 계산하는 예가 도시되어 있다. 도 5에서는 265개 약물을 18(Dn)개 약물 pathway로 분류하여 적용을 하고, 기능하플로타입은 12개 암종(Cancer N)에 대하여 각 세포주 유전체에서 양적형질 위치(QTL) 정보기반으로 이미 약물반응과 관련을 가지고 있는 변이들의 조합(다중변이)들을 해시 수(hash number)로 바꾸어서, Pearson 상관관계를 구하는 형태의 계략도를 보여준다.
그리고 도 6은 양적형질 위치(QTL)와 약물반응 상관관계 예시도도를 보여 주고 있다. ①은 eQTL, ②는 cQTL, ③은 dQTL, ④는 유전자 RNA 발현과 유전자복제수변이의 상관관계, ⑤는 약물농도와 유전자 RNA발현, ⑥은 약물농도와 유전자복제수변이와의 상관관계를 보여준다.
본 발명에서 ① eQTL 및 ② cQTL이 사용되고, ③ 내지 ⑥은 결과물로서 혹은 상관관계가 있는 상태를 보여준다.
도 7은 변이, RNA발현, 유전자복제수변이 및 약물반응의 네트워크 구조를 나타내는 예시도로, 도 6에 도시된 내용을 서로 간의 연관성 관점으로 네트워킹을 만든 계략도이고, 지노타입(단일 변이), 하플로타입(조합 및 다중변이) 및 약물반응과의 조건식들의 관계를 보여준다.
본 발명에서 기능하플로타입은 단일변이 및 다중변이를 모두를 통칭한다.
그리고 각 변이들은 모두 양적형질 위치(QTL)의 방법에 의하여, 유전자 RNA 발현과 유전자복제수변이의 상관관계가 p-value < 10^5 이하로 정하여 수집된다.
한편, 도 8에는 변이와 상관관계 세포주, 암, 약물반응, RNA 발현 및 CNV 증폭의 예가 도시되어 있다. 이때, 상호 연관된 변이와 세포주, 암, 약물반응, RNA 발현 및 CNV 증폭의 예는 최종적으로 선별된 양적형질 위치(QTL)기반 약물반응성-변이-RNA발현-CNV가 하나의 객체로서 묶여 있다.
또한, 변이(지노타입)은 염색체의 위치, 변이 타입, 아미노산변이, 바이오마커로서의 활용 유무정보 등과도 연결될 수 있다.
한편, 도 9에 도시된 기능하플로타입과 약물반응성 상관관계 계산 스키마에 의하면, 본 발명은 크게 제1단계 및 제2단계로 구성된다.
제1단계는 양적형질 위치(QTL)들의 위치 모음을 생성하는 단계이고, 제2단계는 기능하플로타입과 약물반응 상관관계 계산하는 단계이다.
구체적으로, 제1단계는 1) 변이(전체 4백만)와 유전자들(20,000)의 발현 상관관계 계산하는 단계와, 2) 약물(265개)과 셀라인 유전체(1,000개)의 유전자발현과(각 20,000 여개)의 상관관계 계산하는 단계와, 3) 1) 및 2)에서 다중 혹은 단일변이와 연관을 가진 유전자발현 패턴이 같은 것을 수집하는 단계 및 4) 유전체통합DB에서 하플로타입(단일 및 다중변이)을 약물반응성과 함께 추출하는 단계를 포함하여 수행된다.
그리고 제2단계는 5) 이와 같은 하플로타입을 기능과 연관관계 하플로타입인 기능하플로타입(FRH)으로 정의하고, FRH를 해시넘버 (hash number)로 표현하는 단계 및 6) 해시넘버와 약물반응성 조합 상관관계 테스트(Pairwise Pearson Test)를 계산하는 단계를 포함하여 수행되고, 이들 과정을 모든 암 종에서 반복 수행한다.
또한, 도 10에는 기능하플로타입과 약물반응성의 네트워크가 도시된 것으로, 도 9에 도시된 기능 하플로타이핑 방법을 구현하기 위한 시스템을 나타낸다.
즉, QTL방법에 의한 단일 혹은 다중변이와 유전자 RNA발현 및 약물 반응데이터의 관계 및 Genotype으로 구성된 Cell Lines(c1~c-N) 통합 DB에서 다중변이를 추출하여 기능하플로타입을 추출하는 과정이 도시되어 있다.
그리고 도 11의 기능하플로타입과 유전자 RNA 발현 및 유전자복제수변이 예시도에는, 기능적인 관점에서 도 9의 과정을 구체적으로 설명을 한다.
즉, A)는 약물반응성 정보와 유전자 RNA발현의 관계를 최종결과물인 다중면이(loci)와 Exp으로 표현되고, 약물반응성 정보와 유전자복제수변이(CNV)의 관계를 loci와 CNV로 표현됨을 나타내고 있다.
그리고 B)는 이에 대한 상세 스키마로, 약물의 경우 Ln Ic50의 경우 '-2'는 민감성을 나타내고, '0'은 중간 민감성을 나타내며, '2'는 약물내성을 나타낸다.
한편, 다중변이(loci)는 양적형질 위치(QTL)기반으로 선별된 locus들의 모음으로 설명되고, loci는 다양한 타입인 loci-1, loci-2, ... loci-N으로 표현이 되며, 각 loci 타입은 전체 집단에서의 빈도(frequency)를 가지게 된다.
그리고 각각의 빈도 군에서 평균 약물반응성 정보인 ln IC50값(X, Y, …Z)이 산출된다.
한편, 유전자 RNA발현의 경우는 3가지 다른 발현 패턴을 가지는데, 이는 과발현(over-expression), 변화없음(normal), 및 저발현(under-exprfession)형식으로 표현이 될 수 있고, loci 타입과 같은 방식으로 각 타입에서 빈도(frequency)가 그룹화가 될 수 있고, 각 그룹에서의 평균 Ln IC50값(X', Y', …Z')이 산출된다.
그리고 같은 방식으로 복제수변이인 CNV의 경우도 증폭(amplification), 변화없음(normal) 및 감소(deletion)로 구분되고, 각 빈도(frequency) 군(group)에서 평균 약물반응성 정보인 ln IC50값(X", Y", …Z")이 산출된다.
또한, loci, gene-exp, gene-CNV 모두 다 빈도값이 가중치형태로 0~1의 스케일로 표현될 수 있다.
따라서, B)는 loci와 Exp, loci와 CNV에 가중치가 곱해진 것으로 설명될 수 있다.
도 12는 기능 하플로타입 정의를 나타내는 것으로, 본 발명에서 상대 기능 하플로타입(relative-Haplotype)이라 함은, 기능하플로타입(FRH)과 eQTL에서 유의성을 주는 locus들의 조합(Loci)으로서 기능적으로 연관된 하플로타입 관계를 말한다.
여기서, 기능하플로타입은 게놈 어셈블버전인 Dec. 2013 (GRCh38/hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 참고(reference)서열을 기준으로 개별 세포주 및 개인이 다른 다형성정보(allele)를 가진 형태로 정의된다. 그리고 FRH(Exp | IC50)는 유전자 발현차이에 대한 약물반응 절대값 민감도 차이(Normal 대 Over 혹은 Under)를 나타내고, FRH(Loci | IC50)는 세포주 들에 대한 기능적으로 연관된 하플로타입에 대응된 약물반응 절대값 민감도 차이를 말한다.
따라서, 약물반응값과 유전자 RNA발현의 관계와, Loci의 특정 타입과 같은 패턴의 유전자 RNA발현을 연결을 지을 수 있고, 일 예로, 도 12에서, [2]의 loci-3과 [1]Exp-over와 연결되어 있음을 보여준다.
즉, loci-3은 RNA발현이 over가 되는 것과 QTL관계에 있고, RNA발현이 over가 되어 있을 때 약물반응성 값은 loci-3의 약물발현성 값과 같은 것으로 예측할 수 있다.
또한, [3]에 도시된 바와 같이, FRH(Exp | IC50)은 변화없음(normal)에서의 약물반응성값과 비교하여 절대값 약물반응성 차이가 큰 값(max)를 나타내고, FRH(Loci | IC50)는 다양한 하플로타입에서의 약물반응 변화없음(normal)에서의 약물반응성 값과 비교하여 절대값 약물반응성 차이가 가장 큰 값(max)를 나타낸다.
한편, 도 13에는 FRH 방법과 유전자 발현과 약물 반응성을 예측한 예를 통하여, 도 12에 정의된 하플로타입을 좀 더 구체적으로 설명을 할 수 있다.
즉, 도 13의 [1] 및 [2]은 유전자 발현차이에 대한 약물반응 절대값 민감도 max 차이(Normal 대 Over 혹은 Under)를 각각 나타내고, [3]은 세포주 들에 대한 기능적으로 연관된 하플로타입에 대응된 약물반응 절대값 민감도 max 차이를 나타내며, [4]는 발현 차이에 대한 약물반응의 차이가 저발현 보다 더 크면 s=1, 그리고, 그 반대면 s=0이라 정의하는 것을 나타낸다. 따라서, s=1은 과발현이 약물반응에 민감하다는 것이고, S=0은 저발현이 약물반응이 민감하다는 것을 의미한다.
그리고 [5]는 [1] 및 [2]에서 정의한 ds^over가 ds^under보다 크면 m=1, 그렇지 않으면 m=0이라 정의하는 것을 나타내고, m=1이면 특정 loci타입이 유전자의 경우 과발현을 의미하고, m=0일 경우 유전자의 저발현이 특정 loci타입와 연관됨을 의미한다.
한편, 도 14는 FRH의 한 예시로 평균 IC50 값의 차이가 '1.0'인 예의 데이터를 표로 보여준다. 여기서, 평균 약물반응성(LN IC50)이 1인 경우 높은 양성 상관관계를 보인다 (pval <2.812*10^-7).
그리고, 도 15는 FRH의 한 예시로 평균 IC50 값의 차이가 '1.5'인 예의 데이터를 표로 보여준다. 여기서, 평균 약물반응성(LN IC50)이 1.5인 경우 훨씬 높은 음성 상관관계를 보인다 (pval <7.191*10^-7).
또한, 도 16에는 기능적으로 연관된 하플로타입과 유전자발현 실시예가 도시되어 있다.
이 실시예의 경우, 혈액암(blood)의 경우, FRH이 4개의 타입을 포함하는 것을 보여준다. 이때, 변이(locus위치)는 1: Ref Homo, 2: Hetero, 3: Alt Homo의 3개의 다른 지노타입(genotype)으로 설명이 된다.
그리고 첫 번째 컬럼의 혈액암(blood)에서 2개의 locus의 조합으로 표현하면, 각 타입의 빈도(frequency)는 두 번째 컬럼, '12'는 1명, '21'은 1명, '11'은 2명 그리고 '22'는 153명으로 다수를 보여준다.
또한, Afatinib 약물에 대하여 '11'의 경우 유전자발현은 과발현(2.404)이고, 약물반응성(LN IC50)은 -1.21, 즉 Afatinib 약물에 대하여 민감성이 있다는 것을 보여준다. 이 예시의 내용을 요약하면, 2개의 locus를 조합으로 하는 FRH는 '11' 타입에서 EGFR 유전자가 과발현되고, 그것이 원인이 되어서 약물반응성이 민감하다. 따라서, FRH는 '11' 타입을 가지는 세포주 및 환자는 Afatinib약물에 민감하다고 예측할 수 있다.
그리고 도 17에는 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델 생성 방법이 도시되어 있다. 이에 도시된 바와 같이, 특정 암 약물 패스웨이(pathway)기반 약물반응 예측모델은 1) 기능연관 하플로타입(FRH)과 특정암의 특정약물 패스웨이(Drug Pathway)와 관련된 각 약물과의 상관관계를 계산하고, 2) FRH 및 약물반응성 상관관계로 구성되는 메트릭스 X축 및 Y축의 상관관계 정보를 클러스터링을 하고, 3) 예측모델에서 유의성(p-value)이 높은 것을 수집하여, 이들의 상호작용 기능을 모델에 적용하고, 4) NGS 데이터를 입력으로 하여 약물반응성과 연관을 가진 FRH를 계산하여 약물반응성을 예측한다.
한편, 도 18에 도시된 기능하플로타입과 약물반응성 연관관계 R^2는 도 17의 예측모델 생성 방법의 2)상관관계 정보의 클러스터링 과정의 일 예를 설명한다. 여기서, 암 타입은 혈액암이고, Y: EGFR pathway 9 drugs, X: FRH 하플로타입 그리고 각 pixel은 약물반응값과 FRH의 Pearson 상관관계를 나타내고, 여기서 *는 유의성(pval<0.05)을 나타내고, **는 유의성(pval<0.01)을 나타낸다.
또한, 파랑색은 양성으로의 상관관계를 보여주고, 주황색은 음성으로의 상관관계을 보여준다.
그리고 도 19는 도 18의 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH의 예를 보여준다. 특히, 4개 FRH(LAMC2_2, JPH1_2, PRKCB_3, CML_1)와 약물반응성 상관관계를 결과를 나타내고 있다.
한편, 도 20은 도 18의 예에서, Afatinib 약물과 FRH 상관관계가 높은 FRH를 사용한 예측 모델의 일 예로, 도 17의 예측모델 생성 방법의 3) 상호작용 기능을 모델에 적용한 일 예를 설명한다. 특히, p-val<0.01이하인 FRH 21개는 상호작용 텀(term)으로 넣고, 선형 회귀(Leaner Regression)모델을 적용한 예시이다. 이 경우는 Pearson 상관관계가 0.89이다.
또한, 도 21은 혈액암 환자 1명 유전체의 기능하플로타입을 가지고 다양한 약물(AP-24534, PAC-1, Obatoclax Mesylate, Bleomycin 등)에 대한 예측된 IC50(real)값들을 보여준다. 이 결과 어떤 약물은 높은 민감도가 예측된 반면, 떤 약물은 높은 저항성이 예측된 것으로 나타난다. 그리고 실제값(IC50(real))의 민감도와 기능하플로타입 군의 평균 IC50(ave)값 사이에 일치성이 있음을 보여준다.
한편, 도 22에 도시된 바와 같이, 본 발명에 의한 차세대시퀀싱데이터 기반의 개인별 기능하플로타입들이 수집되면 다양한 영역에서 활용이 가능하다. 즉, 가상임상시험 및 실제임상시험, 신약표적발굴, 질병 약물 민감도 진단, 및 동반진단 바이오마커 발굴 시스템 등에 활용가능하다.
본 발명에서는 전술한 바와 같은 기능하플로타입을 통하여, 약물 반응성을 진단하는데 유의성있는 바이오 마커들을 발굴하였다.
발굴된 바이오 마커는 변이를 포함하는 DNA 염기로 크게 암의 종류(CancerClass) 별로 해당 암에 대한 약물의 반응성에 영향을 미치는 바이오 마커들과, 약물의 작용 경로(pathway) 및 표정 대상에 따라 구분되는 약물타입(DrugClass)에 별로 약물의 반응성에 영향을 미치는 바이오 마커들로 구분된다.
이하에서는 이와 같은 바이오 마커들을 종류별로 구분하여 정리하기로 한다.
먼저, 암타입(CancerClass)에 대한 구분 종류가 [표 1]에 정리되어 있다.
| 구분 | CancerClass | TCGA | CANCER_NAME |
| 1 | 혈액암(blood) | ALL LAML LCML |
Acute lymphoblastic leukemia, Acute Myeloid Leukemia, Chronic Myelogenous Leukemia |
| 2 | 여성암(breast, ovary) | BRCA BLCA UCEC OV CESC |
Bladder Urothelial Carcinoma, Breast invasive carcinoma, Ovarian serous cystadenocarcinoma, Cervical squamous cell carcinoma and endocervical adenocarcinoma, Uterine Corpus Endometrial Carcinoma |
| 3 | 뇌종양(brain) | LGG NB GBM |
Glioblastoma multiforme, Brain Lower Grade Glioma, Neuroblastoma (nb) |
| 4 | 두경부암(head&neck) | HNSC THCA |
Head and Neck squamous cell carcinoma, Thyroid carcinoma |
| 5 | 폐암(lung) | LUAD LUSC NSCLC |
Lung adenocarcinoma, Lung squamous cell carcinoma |
| 6 | 육종암(bone) | SARC | Sarcoma |
위 [표 1]에 기재된 Cancer Class는 암발생부위 및 원인별 구분으로, 혈액암(blood), 여성암(breast, ovary), 뇌종양(brain), 두경부암(head&neck), 폐암(lung), 육종암(bone)으로 구분된다.
그리고 TCGA는 'The cancer genome atlas'에서 분류한 세부 암 유형을 나타내고, 각 항목에 대한 정보가 [표 1]에 기재되어 있다.
전술한 바와 같이, 본 발명에서는 기능하플로타입을 이용한 GBLscan을 통하여, 각 암 종류별로, 약물에 대한 반응성에 영향을 미치는 바이오마커를 산출하였다.
구체적으로, 암타입(Cancer Class)의 구분 별로, 혈액암(blood)의 바이오 마커 225개(표 2참조), 여성암(breast, ovary) 바이오 마커 50개(표 4참조), 뇌종양(brain)의 바이오 마커 894개(표 6참조), 두경부암(head&neck)의 바이오 마커 32개(표 8참조), 폐암(lung)의 바이오 마커 277개(표 10참조), 육종암(bone)의 바이오 마커 331개(표 12참조)이다.
아래 [표 2] 내지 [표 12]에는 암 종류별로 본 발명에 의해 발굴된 바이오 마커가 표시되어 있다. 여기서 바이오 마커는 단일변이 및 다중변이의 조합일 수 있고, 변이의 형태 역시 단일염기다형성변이(SNV), 인델(Indel), 유전자 복제수 변이(CNV), 염색체 전위(chromosomal rearrangement) 등 다양한 형태의 변이일 수 있다.
한편, 본 발명에서 표시되는 Gene_EXP는 도 24에 도시된 바와 같이, 해당 바이오마커의 mRNA 발현유전자의 명칭을 나타낸다. 그리고 상기 바이오 마커는 『표식1_표식2_표식3_표식4』의 형태로 표현되는데, 표식1은 변이가 포함된 염색체번호를 나타내는 것으로 1 내지 22 또는 X, Y 중 어느 하나의 값을 갖는다. 그리고 표식2는 해당 염색체 상에서 변이가 발생된 염기서열의 시작위치를 나타내는 것이며, 표식3은 변이 전 정상 염기를 나타내는 것으로 참조게놈(GRCh/hg38 기준)상의 해당 위치의 염기를 말한다. 한편, 표식4는 변이된 염기를 나타내는 것이다.
즉, [표 2] 내지 [표 12] 및 [표 15] 내지 [표 27]에 표시된 『표식1_표식2_표식3_표식4』의 형태로 표현된 변이는, 표식1 염색체에 있어, 표식2 번째 부터의 표식3 염기가 표식4로 변이된 염기서열을 말한다.
따라서, 이때, 바이오 마커는 구체적으로, 표식1 염색체에 있어, 표식2 번째 위치에서부터의 표식3의 염기 길이까지의 자리가 표식4의 염기로 구성되는 염기서열을 말한다.
예를 들어, [표 2]의 서열1의 바이오마커가 『14_30910985_T_G』로 표현되었는데, 이는 14번 염색체의 30910985번째 염기가 G인 염기서열이 바이오 마커임을 의미하고, [표 2]의 서열5의 바이오마커가 『13_113524119_TGTCA_T, 13_113510211_T_C, 13_113495576_T_C, 13_113503637_G_T, 13_113539563_C_T』로 표현되었는데, 이는 13번 염색체의 113524119번째 염기부터 113524123까지의 염기가 T이고(4자리의 염기는 '결실'됨을 의미한다), 13번 염색체의 113510211번째 염기가 C이며, 13번 염색체의 113495576번째 염기가 C이고, 13번 염색체의 113503637번째 염기가 T이며, 13번 염색체 113539563번째 염색체가 T인 염기서열이 바이오마커임을 의미한다.
도 24에 도시된 예를 살피면, [표 23]의 서열 29에 기재된 바이오 마커는, 'SLC6A12'염색체에서, 2번 염색체의 190673067번째 염기가 GT이고, 9번째 염색체의 114323991번째 염기가 G인 것을 의미한다. 이때, 2번 염색체의 190673067번째 염기는 G가 GT로 치환된 것임을 말한다.
한편, 1 내지 22번 염색체의 전체 염기서열은 전술한 바와 같이, 게놈 어셈블버전인 Dec. 2013 (GRCh38/hg38): Genome Reference Consortium Human 38 (GCA_000001405.15), https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.26 참고(reference)서열을 기준으로 한다.
[표 2]에는 혈액암(blood) 약물에 연관된 FRH 들과, 이와 연관된 혈액암 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 3] 에는 [표 2]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, [표 2]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 2]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 혈액암 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 25에는 표 2에 기재된 바이오마커들 중 주요 바이오마커들의 혈액암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 26에는 주요 바이오마커들에 의해 발현된 유전자들과 혈액암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Drug | DrugType | Var(마커) |
| 1 | MYB_5 | 1017_Olaparib / 1054_PD-0332991 / 1175_AG-014699 / 1006_Cytarabine / 1013_Nilotinib / 1495_Olaparib / 1010_Gefitinib / 1050_ZM-447439 / 1019_Bosutinib / 1011_ABT-263 / 1021_Axitinib / 1018_ABT-888 / 1037_BX-795 / 1046_681640 / 263_FR-180204 / 6_PHA-665752 / 1053_MK-2206 / 1032_Afatinib / 1015_CI-1040 / 1020_Lenalidomide / 1066_AZD6482 / 308_XL-880 / 1033_Vismodegib / 1014_RDEA119 / 1049_PD-173074 / 1038_NU-7441 | g_integrity / cell_cyc / g_integrity / DNArep / abl / g_integrity / egfr / mitosis / abl / apop / rtk / g_integrity / other / cell_cyc / erk_mapk / rtk / pi3k / egfr / erk_mapk / other / pi3k / rtk / other / erk_mapk / rtk / g_integrity | 13_37746458_AA_A / 16_46710765_T_A / 11_63382198_CA_C / 14_68477626_CT_C / 7_151221500_CT_C |
| 2 | CCND3_2 | 1006_Cytarabine_1 / 226_GSK1070916_2 / 32_Tozasertib_2 / 1054_Palbociclib_2 / 231_FMK_3 / 1050_ZM447439_3 / 167_OSU-03012_3 / 59_WZ-1-84_3 / 197_Bryostatin_1_2 / 1495_Olaparib_1 / 177_GSK650394_3 / 282_Pelitinib_2 / 300_CX-5461_3 | DNArep / mitosis / mitosis / cell_cyc / erk_mapk / mitosis / pi3k / other / other / g_integrity / other / egfr / other | 14_68477626_CT_C / 7_151221500_CT_C |
| 3 | CLEC11A_2 | 1014_Refametinib_2 / 1526_Refametinib_3 / 1060_PD0325901_2 / 263_FR-180204_3 / 1242_(5Z)-7-Oxozeaenol_3 / 1015_CI-1040_2 / 224_AS605240_3 / 1498_Selumetinib_2 / 254_Quizartinib_2 / 29_AZ628_3 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / pi3k / erk_mapk / rtk / erk_mapk | 16_46710765_T_A / 5_179863845_T_G |
| 4 | SLFN11_1 | 1494_SN-38_3 / 1259_Talazoparib_3 / 136_Mitomycin-C_1 / 1003_Camptothecin_1 / 1006_Cytarabine_1 / 226_GSK1070916_2 / 134_Etoposide_1 / 1005_Cisplatin_1 / 135_Gemcitabine_1 | DNArep / g_integrity / DNArep / DNArep / DNArep / mitosis / DNArep / DNArep / DNArep | 1_215675245_T_C |
| 5 | GLUL_1 | 1013_Nilotinib_1 / 1021_Axitinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 34_Imatinib_1 / 52_GNF-2_3 / 1050_ZM447439_3 | abl / rtk / erk_mapk / erk_mapk / abl / abl / mitosis | 16_46710765_T_A |
| 6 | ARRB1_1 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 29_AZ628_3 / 263_FR-180204_3 / 1242_(5Z)-7-Oxozeaenol_3 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / other | 16_46710765_T_A |
| 7 | UBASH3B_1 | 1006_Cytarabine_1 / 226_GSK1070916_2 / 1050_ZM447439_3 / 211_TL-2-105_3 / 1054_Palbociclib_2 / 279_BIX02189_3 / 282_Pelitinib_2 | DNArep / mitosis / mitosis / erk_mapk / cell_cyc / other / egfr | 14_68477626_CT_C |
| 8 | TNFRSF1A_2 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 29_AZ628_3 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk | 16_46710765_T_A / 6_71969190_A_G |
| 9 | FLT3_1 | 277_Linifanib_2 / 249_Cabozantinib_1 / 254_Quizartinib_2 / 308_WIKI4_2 / 226_GSK1070916_2 / 222_BX-912_3 / 153_Midostaurin_2 | rtk / rtk / rtk / rtk / mitosis / pi3k / rtk | 2_110841381_C_T |
| 10 | TAF3_1 | 1060_PD0325901_2 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk | 1_75148689_A_T |
| 11 | RNF169_1 | 1013_Nilotinib_1 / 1021_Axitinib_2 / 261_TL-1-85_3 / 260_NG-25_3 / 211_TL-2-105_3 / 295_NVP-BHG712_3 | abl / rtk / other / other / erk_mapk / rtk | 6_119180436_T_TAA |
| 12 | AGTRAP_1 | 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 1015_CI-1040_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk | 2_178769706_G_T |
| 13 | DDX60L_1 | 1014_Refametinib_2 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 224_AS605240_3 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / pi3k | 6_143772215_C_T |
| 14 | MARCH9_1 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1526_Refametinib_3 / 1015_CI-1040_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk | 14_30910985_T_G |
| 15 | OSBPL5_1 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1242_(5Z)-7-Oxozeaenol_3 / 1372_Trametinib_1 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk | 2_232380431_T_C |
| 16 | ZNF22_1 | 300_CX-5461_3 / 272_AR-42_2 / 226_GSK1070916_2 / 274_Belinostat_1 / 257_NPK76-II-72-1_3 / 276_CAY10603_3 | other / chromatin / mitosis / chromatin / mitosis / chromatin | 2_97507111_G_A |
| 17 | DGAT1_3 | 1014_Refametinib_2 / 1526_Refametinib_3 / 1021_Axitinib_2 / 1013_Nilotinib_1 / 1060_PD0325901_2 / 1011_Navitoclax_2 | erk_mapk / erk_mapk / rtk / abl / erk_mapk / apop | 3_38910262_T_C / 11_18484005_G_A / 3_38905381_A_T |
| 18 | ORMDL3_2 | 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk | 19_49044101_A_G / 2_178769706_G_T |
| 19 | ROPN1L_2 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 / 1526_Refametinib_3 / 1015_CI-1040_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk | 16_33978977_C_T / 2_200876848_T_C |
| 20 | MSI2_1 | 1498_Selumetinib_2 / 1526_Refametinib_3 / 1060_PD0325901_2 / 1014_Refametinib_2 / 1372_Trametinib_1 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk | 22_43972861_C_T |
| 21 | PSTPIP2_2 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1015_CI-1040_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk | 6_143772215_C_T / 6_143760631_C_A |
| 22 | MYL6B_1 | 1498_Selumetinib_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1060_PD0325901_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk | 11_284257_G_A |
| 23 | LPAR6_2 | 1011_Navitoclax_2 / 1054_Palbociclib_2 / 1021_Axitinib_2 / 1050_ZM447439_3 / 226_GSK1070916_2 | apop / cell_cyc / rtk / mitosis / mitosis | X_136033510_GA_G / 12_131908770_A_C |
| 24 | RIPK2_5 | 231_FMK_3 / 226_GSK1070916_2 / 225_Genentech Cpd 10_3 / 203_BMS-345541_3 / 205_Avagacestat_2 | erk_mapk / mitosis / mitosis / other / other | 6_152444591_GA_G / 19_13993876_CT_C / 13_37746457_TAA_TA / 5_64507681_TA_T / 10_67956845_TA_T |
| 25 | KIF15_1 | 1006_Cytarabine_1 / 1054_Palbociclib_2 / 1050_ZM447439_3 / 226_GSK1070916_2 | DNArep / cell_cyc / mitosis / mitosis | 15_100152748_G_A |
| 26 | ATP11A_2 | 1498_Selumetinib_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1060_PD0325901_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 2_85880864_T_C / 3_132388903_G_A |
| 27 | ZYX_1_9 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 / 1526_Refametinib_3 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 11_129905704_C_T |
| 28 | SNRPG_5_5 | 1498_Selumetinib_2 / 1060_PD0325901_2 / 1014_Refametinib_2 / 1372_Trametinib_1 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 7_12369637_C_A / 7_12369701_C_T / 7_12369909_A_G / 7_12361157_C_T / 7_12361395_C_T |
| 29 | RABGAP1_4_4 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1015_CI-1040_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 3_10260372_A_G / 17_20204460_T_C / 17_20357788_A_G / 17_20205876_C_T |
| 30 | AEBP1_5_4 | 1006_Cytarabine_1 / 167_OSU-03012_3 / 182_Obatoclax Mesylate_2 / 226_GSK1070916_2 | DNArep / pi3k / apop / mitosis | 16_13922252_CT_C / 13_37746457_TAA_TA / 1_108982799_TA_T / 6_152444591_GA_G / 17_64858885_TA_T |
| 31 | HNRNPA0_5_7 | 226_GSK1070916_2 / 300_CX-5461_3 / 134_Etoposide_1 / 225_Genentech Cpd 10_3 | mitosis / other / DNArep / mitosis | 11_63382198_CA_C / 15_42211755_GA_G / 15_55680462_CT_C / 20_34750522_TA_T / 11_33353067_AT_A |
| 32 | PVRL2_1_15 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 / 34_Imatinib_1 | erk_mapk / erk_mapk / erk_mapk / abl | 17_999610_T_C |
| 33 | KIAA1377_1_4 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 19_2896950_T_C |
| 34 | THEM4_5_4 | 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 / 300_CX-5461_3 / 175_PAC-1_2 | mitosis / pi3k / other / apop | 13_37746457_TAA_TA / 7_151221500_CT_C / 1_108982799_TA_T / 2_53919250_GA_G / 15_42211755_GA_G |
| 35 | RBM15B_4_4 | 1054_Palbociclib_2 / 1050_ZM447439_3 / 226_GSK1070916_2 / 1006_Cytarabine_1 | cell_cyc / mitosis / mitosis / DNArep | 11_63382198_CA_C / 5_75576972_GA_G / 8_73582883_GA_G / 10_67956845_TA_T |
| 36 | C10orf11_1_7 | 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 1_13344015_T_C |
| 37 | NSMAF_1_7 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 / 29_AZ628_3 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 1_117088769_T_C |
| 38 | FRAT2_2_9 | 1526_Refametinib_3 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 1_215813880_T_C / 1_215838019_T_C |
| 39 | LRPAP1_2_3 | 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 | erk_mapk / erk_mapk / erk_mapk | 7_36335190_G_A / 22_39052745_T_C |
| 40 | PRAM1_3_3 | 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk | 7_128805316_G_A / 2_178769706_G_T / 2_232380380_A_G |
| 41 | RAG1_2_3 | 182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 1006_Cytarabine_1 | apop / apop / DNArep | 19_11301321_TA_T / 4_105719027_C_A |
| 42 | CARHSP1_2_3 | 1006_Cytarabine_1 / 226_GSK1070916_2 / 1054_Palbociclib_2 | DNArep / mitosis / cell_cyc | 14_68477626_CT_C / 13_24781827_GTT_GT |
| 43 | MBLAC1_1_3 | 1498_Selumetinib_2 / 1014_Refametinib_2 / 1372_Trametinib_1 | erk_mapk / erk_mapk / erk_mapk | 3_179365291_C_T |
| 44 | RAG2_3_4 | 1006_Cytarabine_1 / 175_PAC-1_2 / 300_CX-5461_3 | DNArep / apop / other | 3_112112876_TA_T / 12_21806064_CA_C / 19_11301321_TA_T |
| 45 | HNMT_1_4 | 1526_Refametinib_3 / 1498_Selumetinib_2 / 1372_Trametinib_1 | erk_mapk / erk_mapk / erk_mapk | 1_1756186_T_C |
| 46 | KCTD7_2_5 | 1498_Selumetinib_2 / 1014_Refametinib_2 / 1526_Refametinib_3 | erk_mapk / erk_mapk / erk_mapk | 11_63719914_T_C / 11_63646490_AAAAT_A |
| 47 | GSN_1_6 | 1498_Selumetinib_2 / 1372_Trametinib_1 / 1060_PD0325901_2 | erk_mapk / erk_mapk / erk_mapk | 11_129905704_C_T |
| 48 | CBFB_2_5 | 1006_Cytarabine_1 / 182_Obatoclax Mesylate_2 / 1004_Vinblastine_1 | DNArep / apop / cytoskeleton | 15_74183919_A_G / 3_112112876_TA_T |
| 49 | FBXO33_1_4 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 | erk_mapk / erk_mapk / erk_mapk | 8_143538013_T_C |
| 50 | ZBED4_2_4 | 1054_Palbociclib_2 / 257_NPK76-II-72-1_3 / 1011_Navitoclax_2 | cell_cyc / mitosis / apop | 7_100590017_T_G / 22_23698377_AT_A |
| 51 | COPS8_5_6 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1526_Refametinib_3 | erk_mapk / erk_mapk / erk_mapk | 11_69072603_C_T / 11_124023539_A_G / 16_57082546_T_C / 6_31878964_C_A / 7_100220478_G_A |
| 52 | ISG20_1_12 | 1014_Refametinib_2 / 1060_PD0325901_2 / 263_FR-180204_3 | erk_mapk / erk_mapk / erk_mapk | 5_179863845_T_G |
| 53 | LGALS12_3_4 | 1526_Refametinib_3 / 1060_PD0325901_2 / 1014_Refametinib_2 | erk_mapk / erk_mapk / erk_mapk | 14_63384641_T_C / 7_128804766_A_G / 7_128805316_G_A |
| 54 | SNRNP48_5_3 | 1006_Cytarabine_1 / 1050_ZM447439_3 / 1054_Palbociclib_2 | DNArep / mitosis / cell_cyc | 16_57460490_GA_G / 16_30280420_GA_G / 8_108228149_GA_G / 1_179120104_GA_G / 9_67192757_GA_G |
| 55 | VPS37C_3_4 | 182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 205_Avagacestat_2 | apop / apop / other | 5_146267624_CT_C / 3_160416453_CT_C / 12_15623289_TA_T |
| 56 | ATP6V0A1_1_3 | 1494_SN-38_3 / 226_GSK1070916_2 / 1006_Cytarabine_1 | DNArep / mitosis / DNArep | 11_63382198_CA_C |
| 57 | HEATR5A_5_6 | 205_Avagacestat_2 / 226_GSK1070916_2 / 192_LFM-A13_3 | other / mitosis / other | 7_151221500_CT_C / 9_120989554_CT_C / 4_106236542_TA_T / 7_77937691_AT_A / 15_42211755_GA_G |
| 58 | ENG_2_8 | 249_Cabozantinib_1 / 308_WIKI4_2 / 263_FR-180204_3 | rtk / rtk / erk_mapk | 3_186558604_C_T / 22_29806785_G_C |
| 59 | USF1_5_7 | 228_AKT_inhibitor_VIII_3 / 182_Obatoclax Mesylate_2 / 226_GSK1070916_2 | pi3k / apop / mitosis | 6_163478762_CT_C / 17_46332538_GT_G / 7_74758055_CT_C / 9_100450496_GT_G / 1_176043330_GA_G |
| 60 | GRB10_2_11 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1013_Nilotinib_1 | erk_mapk / erk_mapk / abl | 12_56425138_C_T / 7_51028450_A_G |
| 61 | ZNF415_2_4 | 286_KIN001-236_3 / 205_Avagacestat_2 / 167_OSU-03012_3 | other / other / pi3k | 1_225147359_GT_G / 19_1057777_GA_G |
| 62 | DMTF1_1_4 | 1014_Refametinib_2 / 1060_PD0325901_2 / 1372_Trametinib_1 | erk_mapk / erk_mapk / erk_mapk | 1_16758972_T_G |
| 63 | MSL2_4_5 | 226_GSK1070916_2 / 205_Avagacestat_2 / 1050_ZM447439_3 | mitosis / other / mitosis | 13_37746457_TAA_TA / 8_73582883_GA_G / 5_64507681_TA_T / 7_73465568_GA_G |
| 64 | ATP7B_2_6 | 1013_Nilotinib_1 / 261_TL-1-85_3 / 260_NG-25_3 | abl / other / other | 5_176347862_G_T / 5_176336593_G_A |
| 65 | MANBAL_1_5 | 305_TPCA-1_3 / 1013_Nilotinib_1 / 155_Ponatinib_2 | other / abl / abl | 1_24074187_A_G |
| 66 | STOX1_1_3 | 182_Obatoclax Mesylate_2 / 175_PAC-1_2 / 226_GSK1070916_2 | apop / apop / mitosis | 9_67192757_GA_G |
| 67 | PRKCB_2_4 | 261_TL-1-85_3 / 295_NVP-BHG712_3 / 260_NG-25_3 | other / rtk / other | 2_68818005_T_G / 1_24074187_A_G |
| 68 | PNPLA8_3_5 | 224_AS605240_3 / 1014_Refametinib_2 / 1526_Refametinib_3 | pi3k / erk_mapk / erk_mapk | 17_21300996_G_T / 17_21301003_T_C / 17_21301006_A_G |
| 69 | ACCS_3_2 | 1014_Refametinib_2 / 1060_PD0325901_2 | erk_mapk / erk_mapk | 11_44107740_C_A / 9_61066407_C_T / 7_135196179_C_T |
| 70 | BANP_1_2 | 1014_Refametinib_2 / 1060_PD0325901_2 | erk_mapk / erk_mapk | 9_33270750_G_T |
| 71 | ARID1A_2_3 | 1054_Palbociclib_2 / 1050_ZM447439_3 | cell_cyc / mitosis | 7_21862122_CT_C / 11_63382198_CA_C |
| 72 | ELOVL5_1_4 | 1013_Nilotinib_1 / 1054_Palbociclib_2 | abl / cell_cyc | 13_37746457_TAA_TA |
| 73 | N4BP2_5_2 | 175_PAC-1_2 / 257_NPK76-II-72-1_3 | apop / mitosis | 19_11301321_TA_T / 5_146267624_CT_C / 9_120989554_CT_C / 13_37746457_TAA_TA / 16_84087473_CAA_C |
| 74 | LIMS2_5_3 | 205_Avagacestat_2 / 226_GSK1070916_2 | other / mitosis | 3_196805277_CT_C / 11_63382198_CA_C / 15_41478441_CT_C / 6_166418092_GA_G / 14_54478163_TA_T |
| 75 | DPCD_1_2 | 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 | mitosis / pi3k | 15_42211755_GA_G |
| 76 | KATNB1_5_2 | 1006_Cytarabine_1 / 1054_Palbociclib_2 | DNArep / cell_cyc | 4_183646278_TA_T / 20_38562748_GT_G / 1_84490478_CT_C / 2_200412288_CT_C / X_19006308_TA_T |
| 77 | RBM18_1_3 | 1011_Navitoclax_2 / 1014_Refametinib_2 | apop / erk_mapk | 10_131944182_G_C |
| 78 | EWSR1_1_2 | 1054_Palbociclib_2 / 226_GSK1070916_2 | cell_cyc / mitosis | 14_68477626_CT_C |
| 79 | SDC4_1_5 | 245_UNC0638_3 / 196_Phenformin_3 | chromatin / metabol | 1_24074187_A_G |
| 80 | LCK_5_3 | 182_Obatoclax Mesylate_2 / 175_PAC-1_2 | apop / apop | 6_163478762_CT_C / 10_70860377_CT_C / 13_37746457_TAA_TA / 5_64507681_TA_T / 5_146267624_CT_C |
| 81 | GNA15_1_9 | 1011_Navitoclax_2 / 226_GSK1070916_2 | apop / mitosis | 9_33798019_A_G |
| 82 | S1PR2_2_8 | 1014_Refametinib_2 / 224_AS605240_3 | erk_mapk / pi3k | 1_204261453_G_A / 3_54386725_A_G |
| 83 | SOX4_2_2 | 226_GSK1070916_2 / 1006_Cytarabine_1 | mitosis / DNArep | 13_37746457_TAA_TA / 6_152444591_GA_G |
| 84 | MPP1_1_19 | 1013_Nilotinib_1 / 263_FR-180204_3 | abl / erk_mapk | 9_33798019_A_G |
| 85 | TRIM26_1_5 | 277_Linifanib_2 / 1526_Refametinib_3 | rtk / erk_mapk | 11_129905704_C_T |
| 86 | NRN1_2_2 | 1006_Cytarabine_1 / 175_PAC-1_2 | DNArep / apop | 20_24959128_C_T / 6_136108863_GA_G |
| 87 | PHACTR2_1_4 | 1014_Refametinib_2 / 1060_PD0325901_2 | erk_mapk / erk_mapk | 5_146013801_C_T |
| 88 | TRAF3IP2_2_2 | 1175_Rucaparib_3 / 1017_Olaparib_2 | g_integrity / g_integrity | 1_149929093_CA_C / 12_27688992_CT_C |
| 89 | MLF1IP_1_2 | 1054_Palbociclib_2 / 1006_Cytarabine_1 | cell_cyc / DNArep | 10_69097096_G_A |
| 90 | PELI2_5_7 | 226_GSK1070916_2 / 257_NPK76-II-72-1_3 | mitosis / mitosis | 3_129433338_GT_G / 19_11301321_TA_T / 6_152444591_GA_G / 5_60605865_GA_G / 11_63382198_CA_C |
| 91 | HNRNPA1L2_1_2 | 1054_Palbociclib_2 / 1006_Cytarabine_1 | cell_cyc / DNArep | 11_33353067_AT_A |
| 92 | BCL11B_5_3 | 205_Avagacestat_2 / 231_FMK_3 | other / erk_mapk | 13_24781827_GTT_GT / 10_67956845_TA_T / 3_196805277_CT_C / 11_63382198_CA_C / 19_13993876_CT_C |
| 93 | TTF1_5_6 | 226_GSK1070916_2 / 1006_Cytarabine_1 | mitosis / DNArep | 8_28850105_GA_G / 6_163478762_CT_C / 13_37746457_TAA_TA / 11_63382198_CA_C / 5_146267624_CT_C |
| 94 | SKA3_1_2 | 1054_Palbociclib_2 / 1006_Cytarabine_1 | cell_cyc / DNArep | 6_163478762_CT_C |
| 95 | ECI1_1_2 | 205_Avagacestat_2 / 1072_Avagacestat_2 | other / other | 1_247588429_C_G |
| 96 | LAPTM4B_1_8 | 1014_Refametinib_2 / 1060_PD0325901_2 | erk_mapk / erk_mapk | 20_56366031_C_T |
| 97 | C11orf74_4_5 | 1014_Refametinib_2 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 2_237751320_TAA_T / 16_21533198_T_C / 2_216109160_C_A / 16_21520152_G_A |
| 98 | RNF24_1_12 | 1014_Refametinib_2 / 1060_PD0325901_2 | erk_mapk / erk_mapk | 5_179863845_T_G |
| 99 | CRB3_1_4 | 1021_Axitinib_2 / 277_Linifanib_2 | rtk / rtk | 15_98922244_C_T |
| 100 | CNTROB_5_3 | 226_GSK1070916_2 / 1050_ZM447439_3 | mitosis / mitosis | 16_15068286_TA_T / 5_64507681_TA_T / 8_42906145_TC_T / 3_129433338_GT_G / 1_179120104_GA_G |
| 101 | KIAA1967_5_2 | 211_TL-2-105_3 / 257_NPK76-II-72-1_3 | erk_mapk / mitosis | 11_107336715_TA_T / 1_22491646_AT_A / 22_23698377_AT_A / 13_37746457_TAA_TA / 3_196805277_CT_C |
| 102 | KRT10_1_3 | 1014_Refametinib_2 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 7_92671549_C_T |
| 103 | VIT_1_2 | 1526_Refametinib_3 / 1498_Selumetinib_2 | erk_mapk / erk_mapk | 1_176944072_A_T |
| 104 | TMEM173_2_7 | 1526_Refametinib_3 / 1014_Refametinib_2 | erk_mapk / erk_mapk | 1_201199371_G_A / 1_201200426_T_G |
| 105 | SGCB_1_3 | 1014_Refametinib_2 / 1015_CI-1040_2 | erk_mapk / erk_mapk | 17_40035671_A_G |
| 106 | DTD1_3_4 | 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 | mitosis / pi3k | 5_77411610_TA_T / 2_15396385_GA_G / 11_63382198_CA_C |
| 107 | DYSF_1_3 | 1014_Refametinib_2 / 1015_CI-1040_2 | erk_mapk / erk_mapk | 1_25390874_C_G |
| 108 | AP2S1_1_3 | 1060_PD0325901_2 / 1372_Trametinib_1 | erk_mapk / erk_mapk | 10_68572309_C_T |
| 109 | EMILIN2_1_11 | 1526_Refametinib_3 / 1014_Refametinib_2 | erk_mapk / erk_mapk | 5_179863845_T_G |
| 110 | SLC38A1_1_6 | 1014_Refametinib_2 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 7_114653804_G_T |
| 111 | SGSM2_4_1 | 226_GSK1070916_2 | mitosis | 13_97982483_AT_A / 2_63842143_GA_G / 7_77256452_A_G / 4_84631729_G_T |
| 112 | ADAM15_1_1 | 1026_Tanespimycin_2 | other | 1_75148689_A_T |
| 113 | JPH1_2_1 | 211_TL-2-105_3 | erk_mapk | 16_81858185_C_G / 5_128345465_A_C |
| 114 | S100A8_1_3 | 1498_Selumetinib_2 | erk_mapk | 12_11091570_G_A |
| 115 | SQSTM1_2_1 | 182_Obatoclax Mesylate_2 | apop | 13_24781827_GTT_GT / 19_11301321_TA_T |
| 116 | ANXA2_1_1 | 1026_Tanespimycin_2 | other | 4_36214492_A_T |
| 117 | CMBL_1_2 | 1013_Nilotinib_1 | abl | 11_117203393_G_A |
| 118 | CABLES2_1_1 | 1053_MK-2206_2 | pi3k | 17_74794950_A_G |
| 119 | NDST3_2_1 | 205_Avagacestat_2 | other | 13_24781827_GTT_GT / 11_90163472_A_C |
| 120 | LMNA_1_1 | 1026_Tanespimycin_2 | other | 12_120579461_C_T |
| 121 | SP1_5_1 | 333_T0901317_3 | other | 14_35627049_G_GA / 7_23187041_C_T / 2_61835958_TA_T / X_52753184_G_T / 2_119608507_T_G |
| 122 | CDCA7_1_2 | 1054_Palbociclib_2 | cell_cyc | 20_46358679_C_G |
| 123 | NFYB_1_1 | 1006_Cytarabine_1 | DNArep | 20_46358679_C_G |
| 124 | SLFN5_2_1 | 1378_Bleomycin(50uM)_1 | DNArep | 4_186199057_C_A / 6_116125413_A_G |
| 125 | CREG1_3_1 | 1378_Bleomycin(50uM)_1 | DNArep | 9_12704725_C_T / 17_47820165_C_A / 17_47819112_T_C |
| 126 | DAD1_1_1 | 1006_Cytarabine_1 | DNArep | 12_54182016_C_A |
| 127 | SURF4_1_4 | 35_NVP-TAE684_3 | rtk | 14_101856659_C_G |
| 128 | CDK6_1_1 | 1011_Navitoclax_2 | apop | 9_33798019_A_G |
| 129 | TBCD_5_1 | 1054_Palbociclib_2 | cell_cyc | 11_63382198_CA_C / 10_67956845_TA_T / 14_68477626_CT_C / 13_37746457_TAA_TA / 8_73582883_GA_G |
| 130 | FLRT3_1_1 | 1378_Bleomycin(50uM)_1 | DNArep | 17_8012602_G_A |
| 131 | FUCA2_2_1 | 1526_Refametinib_3 | erk_mapk | 12_10418492_T_G / 1_3385157_C_T |
| 132 | MAPK7_1_1 | 1054_Palbociclib_2 | cell_cyc | 7_73465568_GA_G |
| 133 | IER3_1_1 | 1378_Bleomycin(50uM)_1 | DNArep | 20_62310091_T_G |
| 134 | U2AF1_1_1 | 167_OSU-03012_3 | pi3k | 9_76023648_GA_G |
| 135 | PLA2G12A_1_3 | 224_AS605240_3 | pi3k | 1_70189288_A_C |
| 136 | CBX2_2_1 | 1006_Cytarabine_1 | DNArep | 2_161993434_TA_T / 12_109568919_GT_G |
| 137 | MGAT4A_5_1 | 175_PAC-1_2 | apop | 13_37746457_TAA_TA / 20_2493490_GA_G / 6_41090123_AT_A / 2_53919250_GA_G / 16_30280420_GA_G |
| 138 | STARD10_1_1 | 1026_Tanespimycin_2 | other | 20_62327488_A_C |
| 139 | CSRNP2_1_1 | 205_Avagacestat_2 | other | 22_29978883_CT_C |
| 140 | DOK2_2_1 | 1526_Refametinib_3 | erk_mapk | 2_23637298_G_A / 2_23642306_G_A |
| 141 | VOPP1_1_1 | 308_WIKI4_2 | rtk | 22_38427824_A_C |
| 142 | PLOD1_1_1 | 175_PAC-1_2 | apop | 10_99880039_G_A |
| 143 | C3AR1_1_1 | 1014_Refametinib_2 | erk_mapk | 7_147977856_A_T |
| 144 | CYSLTR1_1_1 | 1526_Refametinib_3 | erk_mapk | 11_129905704_C_T |
| 145 | S100A6_1_1 | 1026_Tanespimycin_2 | other | 12_125519394_A_T |
| 146 | ZADH2_1_1 | 1011_Navitoclax_2 | apop | 4_86769845_A_G |
| 147 | EXOSC9_5_2 | 167_OSU-03012_3 | pi3k | 8_108228149_GA_G / 16_57460490_GA_G / 6_31657145_CA_C / 15_50725184_GT_G / 20_33367013_TA_T |
| 148 | ZC3H4_2_1 | 1054_Palbociclib_2 | cell_cyc | 1_247256362_C_T / 1_247256207_T_C |
| 149 | BARD1_1_2 | 175_PAC-1_2 | apop | 9_133405414_T_G |
| 150 | MCL1_1_1 | 1011_Navitoclax_2 | apop | 14_60466034_G_A |
| 151 | NINL_3_4 | 203_BMS-345541_3 | other | 13_24781827_GTT_GT / 13_37746457_TAA_TA / 11_33353067_AT_A |
| 152 | HYI_5_1 | 226_GSK1070916_2 | mitosis | 7_151221500_CT_C / 19_1057777_GA_G / 15_42211755_GA_G / 15_34915209_AT_A / 6_30329241_CA_C |
| 153 | USP49_1_1 | 1006_Cytarabine_1 | DNArep | 7_147638841_CT_C |
| 154 | EPB41_1_3 | 1378_Bleomycin(50uM)_1 | DNArep | 11_1758992_A_C |
| 155 | NFAM1_1_1 | 1526_Refametinib_3 | erk_mapk | 9_15848985_C_T |
| 156 | SIVA1_5_1 | 175_PAC-1_2 | apop | 6_163478762_CT_C / 13_37746457_TAA_TA / 2_161993434_TA_T / 9_120989554_CT_C / 13_39034198_TA_T |
| 157 | LRG1_1_2 | 1026_Tanespimycin_2 | other | 13_28073352_GA_G |
| 158 | TMPRSS15_1 | 1377_Afatinib_1 | egfr | 21_39898596_C_A |
| 159 | G0S2_1 | 281_Alectinib_2 | rtk | 5_35904512_G_T |
| 160 | PPIP5K2_2 | 261_TL-1-85_3 | other | 2_178769706_G_T / 11_129905704_C_T |
| 161 | AGPAT3_4 | 182_Obatoclax Mesylate_2 | apop | 17_76289951_CA_C / 2_63842143_GA_G / 13_97982483_AT_A / 12_48679260_CA_C |
| 162 | AS3MT_5 | 226_GSK1070916_2 | mitosis | 7_20786651_GA_G / 13_24781827_GTT_GT / 7_77937691_AT_A / 3_160416453_CT_C / 5_95507014_TA_T |
| 163 | PIK3R3_1 | 228_AKT_inhibitor_VIII_3 | pi3k | 2_53919250_GA_G |
| 164 | CRY1_2 | 226_GSK1070916_2 | mitosis | 19_1057777_GA_G / 9_33798019_A_G |
| 165 | ZNF367_1 | 226_GSK1070916_2 | mitosis | 12_48679260_CA_C |
| 166 | CAV2_3 | 305_TPCA-1_3 | other | 12_6952191_A_C / 1_24074187_A_G / 2_68818005_T_G |
| 167 | PRKAR2A_5 | 175_PAC-1_2 | apop | 13_37746457_TAA_TA / 7_73465568_GA_G / 7_77937691_AT_A / 12_107746489_GT_G / 6_136108863_GA_G |
| 168 | CDH3_1 | 344_THZ-2-49_3 | cell_cyc | 1_24074187_A_G |
| 169 | PCYOX1L_1 | 271_VNLG/124_3 | chromatin | 5_122946014_G_GT |
| 170 | RNF13_1 | 1054_Palbociclib_2 | cell_cyc | 10_69097096_G_A |
| 171 | CD7_2 | 205_Avagacestat_2 | other | 5_111103810_A_G / 5_111118983_A_G |
| 172 | ZDHHC20_2 | 190_Bleomycin_1 | DNArep | 21_38451144_T_G / 11_47588455_A_C |
| 173 | LGALS3_1 | 211_TL-2-105_3 | erk_mapk | 20_47169235_T_C |
| 174 | FANCD2_1 | 1054_Palbociclib_2 | cell_cyc | 5_161895646_GT_G |
| 175 | TLX2_1 | 344_THZ-2-49_3 | cell_cyc | 1_157833087_T_C |
| 176 | IFT122_1 | 1054_Palbociclib_2 | cell_cyc | 9_33798019_A_G |
| 177 | ZNF423_5 | 175_PAC-1_2 | apop | 3_9977055_TA_T / 7_77937691_AT_A / 21_32744756_GA_G / 11_63382198_CA_C / 9_120989554_CT_C |
| 178 | KDELR1_2 | 185_Linsitinib_2 | igfr | 17_62447686_C_T / X_49304797_C_G |
| 179 | UFM1_1 | 282_Pelitinib_2 | egfr | 8_7811967_A_G |
| 180 | ANKRD22_1 | 281_Alectinib_2 | rtk | 7_38349808_A_G |
| 181 | PLAGL1_3 | 1526_Refametinib_3 | erk_mapk | 11_118551711_A_G / 7_93426338_G_A / 16_28902389_G_T |
| 182 | ZAP70_5 | 205_Avagacestat_2 | other | 13_37746457_TAA_TA / 6_163478762_CT_C / 22_29978883_CT_C / 7_77937691_AT_A / 5_71545270_TA_T |
| 183 | OSBPL11_3 | 1014_Refametinib_2 | erk_mapk | 17_4896602_C_T / 10_122336546_A_C / 10_122336520_T_C |
| 184 | TSPAN7_2 | 205_Avagacestat_2 | other | 6_152444591_GA_G / 2_210663103_GTT_GT |
| 185 | SPAG7_1 | 1047_Nutlin-3a (-)_2 | p53 | 20_63968004_C_T |
| 186 | ABCB10_1 | 1014_Refametinib_2 | erk_mapk | 3_52786995_A_G |
| 187 | WDR83_4 | 1236_UNC0638_3 | chromatin | 16_57460490_GA_G / 14_103670339_GT_G / 1_225147359_GT_G / 16_30280420_GA_G |
| 188 | SLC25A29_5 | 226_GSK1070916_2 | mitosis | 12_25215659_AT_A / 5_70067144_CA_C / 21_32744756_GA_G / 11_63382198_CA_C / 7_28494775_GT_G |
| 189 | SGPP1_1 | 1526_Refametinib_3 | erk_mapk | 1_153645034_CT_C |
| 190 | CD59_1 | 271_VNLG/124_3 | chromatin | 13_23593366_T_A |
| 191 | MRPS21_5 | 1011_Navitoclax_2 | apop | 1_148124171_A_G / 1_247841358_T_G / 3_197622346_A_C / 7_100884179_T_G / 11_72220933_A_C |
| 192 | ILF2_1 | 257_NPK76-II-72-1_3 | mitosis | 19_13993876_CT_C |
| 193 | NRM_1 | 1011_Navitoclax_2 | apop | 11_4082830_A_C |
| 194 | FEM1C_1 | 1378_Bleomycin(50uM)_1 | DNArep | 1_15443607_G_A |
| 195 | PRCP_1 | 190_Bleomycin_1 | DNArep | 3_53179641_T_C |
| 196 | P4HB_1 | 1526_Refametinib_3 | erk_mapk | 2_71427045_G_A |
| 197 | CD44_1 | 1498_Selumetinib_2 | erk_mapk | 8_132137720_G_A |
| 198 | DCTN4_1 | 249_Cabozantinib_1 | rtk | X_3271895_G_A |
| 199 | YIPF5_1 | 275_I-BET-762_3 | chromatin | 18_63655761_T_C |
| 200 | AGPAT2_1 | 1526_Refametinib_3 | erk_mapk | 21_25714604_C_A |
| 201 | FAM136A_1 | 1032_Afatinib_1 | egfr | 16_50711362_A_C |
| 202 | TSPAN32_5 | 271_VNLG/124_3 | chromatin | 22_45399045_C_A / 22_45383455_A_G / 22_45322160_A_G / 4_147906782_T_C / 9_32472897_A_G |
| 203 | PLA2G16_1 | 261_TL-1-85_3 | other | 11_71605554_A_C |
| 204 | MET_2 | 196_Phenformin_3 | metabol | 11_71605554_A_C / 19_39902109_T_G |
| 205 | TMEM97_1 | 281_Alectinib_2 | rtk | 2_113939939_A_G |
| 206 | ZNF839_1 | 176_IPA-3_3 | cytoskeleton | 10_70301448_T_G |
| 207 | ERMAP_4 | 1526_Refametinib_3 | erk_mapk | 4_25662622_G_A / 2_160137837_C_T / 10_111079134_C_A / 2_160138253_A_G |
| 208 | TMEM150A_1 | 1014_Refametinib_2 | erk_mapk | 10_88602550_CT_C |
| 209 | PDIA5_1 | 1526_Refametinib_3 | erk_mapk | 11_18534402_T_C |
| 210 | CLIP1_3 | 1378_Bleomycin(50uM)_1 | DNArep | 11_24976472_CTGTT_C / 7_1155657_T_TC / 7_1092820_C_T |
| 211 | NUDT2_1 | 55_A-770041_3 | other | 14_94592125_A_C |
| 212 | SMYD2_1 | 134_Etoposide_1 | DNArep | 6_26443625_C_A |
| 213 | TMPO_1 | 203_BMS-345541_3 | other | 10_69097096_G_A |
| 214 | ZC4H2_5 | 226_GSK1070916_2 | mitosis | 19_1057777_GA_G / 13_91728769_CA_C / 13_24781827_GTT_GT / 16_30280420_GA_G / 7_77937691_AT_A |
| 215 | TXLNB_1 | 1014_Refametinib_2 | erk_mapk | 20_56366031_C_T |
| 216 | CHID1_3 | 1014_Refametinib_2 | erk_mapk | 15_78939184_A_AG / 15_78922969_A_C / 1_53250744_G_A |
| 217 | TBXAS1_2 | 1526_Refametinib_3 | erk_mapk | 1_13104901_G_A / 1_13116020_T_C |
| 218 | KLHL25_5 | 226_GSK1070916_2 | mitosis | 12_48679260_CA_C / 3_129433338_GT_G / 13_97982483_AT_A / 6_70861991_TA_T / 6_43525297_GT_G |
| 219 | CSF3R_5 | 277_Linifanib_2 | rtk | 16_57082546_T_C / 9_137986862_A_C / 16_57081660_C_T / 17_7771466_C_T / 17_7801487_C_G |
| 220 | SEPHS1_1 | 182_Obatoclax Mesylate_2 | apop | 2_232087433_CT_C |
| 221 | TRAT1_3 | 205_Avagacestat_2 | other | 10_67956845_TA_T / 20_47180038_AT_A / 16_84013157_C_T |
| 222 | BET1_1 | 224_AS605240_3 | pi3k | 1_1638657_A_G |
| 223 | ZNF238_1 | 1026_Tanespimycin_2 | other | 2_151617472_C_A |
| 224 | BST1_1 | 1014_Refametinib_2 | erk_mapk | 3_75338856_G_A |
| 225 | CITED4_1 | 1014_Refametinib_2 | erk_mapk | 3_75338856_G_A |
| No. | FRH | Var_Exp(pval) | Var_Drug(pval) | Exp_Drug(pval) | Ave_VarDrug(pval) | Rank |
| 1 | MYB_5 | 2.44E-11 | 2.33E-06 / 2.99E-05 / 9.07E-05 / 0.000162263 / 0.000181347 / 0.000222215 / 0.00035849 / 0.000514476 / 0.000545979 / 0.000674184 / 0.000765635 / 0.000770681 / 0.001809532 / 0.001834875 / 0.002399212 / 0.002524974 / 0.002550614 / 0.003470781 / 0.003612549 / 0.003858986 / 0.005094315 / 0.006467757 / 0.006664862 / 0.007101459 / 0.009131449 / 0.009396282 | 9.43E-05 / 1.18E-09 / 0.000534893 / 1.91E-08 / 2.60E-05 / 2.14E-05 / 0.178381086 / 3.59E-08 / 0.002198223 / 5.01E-09 / 6.92E-07 / 0.003563123 / 2.90E-06 / 0.0012215 / 4.76E-07 / 5.58E-05 / 0.04742754 / 0.011052464 / 0.001638122 / 0.028671936 / 0.334605149 / 2.70E-05 / 0.120451258 / 0.000163666 / 6.58E-06 / 0.028639924 | 2.70E-03 | 26 |
| 2 | CCND3_2 | 0.0000000001 | 4.077045608756939e-05 / 0.00024222551880903305 / 0.001033946011968038 / 0.007738992794998014 / 0.0011591447239658929 / 0.00039912025376145785 / 0.02164918938012539 / 6.767691357801751e-06 / 0.000284832520137907 / 0.012017653306794376 / 0.0002453692853096132 / 0.0005273716584544123 / 0.005671961091542384 | 1.3348349963172225e-09 / 2.806907767463066e-08 / 1.0352538568715997e-07 / 1.8603881635236497e-07 / 1.1627237502541528e-07 / 3.1401583771073866e-07 / 1.4513640953107782e-06 / 1.658411377465063e-05 / 3.739246289943189e-07 / 1.757546223859833e-06 / 7.270726435772972e-07 / 1.8069518974781594e-07 / 9.210108427954504e-07 | 0.003924411 | 13 |
| 3 | CLEC11A_2 | 0.0000000001 | 0.0005697783607490941 / 0.014056110467957862 / 0.0041011587330335945 / 0.011850911896821052 / 0.0009698603317938078 / 0.04207757694014471 / 0.0027388104840193185 / 0.00017246675352488265 / 0.03592273895483884 / 0.03175705986170069 | 2.242207521501935e-07 / 8.305985309487528e-07 / 4.8336013623637535e-06 / 9.846343563173533e-08 / 6.35432916630242e-05 / 4.269555689878972e-05 / 8.205338044521348e-05 / 2.020761222821706e-05 / 3.783085835895955e-05 / 1.848382097554245e-05 | 0.014421647 | 10 |
| 4 | SLFN11_1 | 0.0000014885 | 2.058410044027094e-07 / 3.2782204810649745e-06 / 0.0004160871569071042 / 6.63292779378419e-05 / 0.006637671888814827 / 0.0022180912856278046 / 0.018399047195112327 / 0.008405657307724725 / 6.561891568628848e-09 | 2.149510966621969e-13 / 1.511769414105504e-12 / 5.5112514063494236e-11 / 1.4108104414924931e-11 / 2.0143854426093352e-07 / 4.658955213551342e-08 / 8.06522811486229e-08 / 7.925927909364347e-07 / 2.303130551346628e-06 | 0.004016264 | 9 |
| 5 | GLUL_1 | 0.0000002831 | 0.00023185717108361177 / 0.006750424182996093 / 0.0002804552471714009 / 0.0005780064318768233 / 0.013252364717981309 / 1.0437921127925209e-05 / 0.0007062900199205474 | 4.534423217653711e-06 / 3.2067677278063803e-07 / 1.3129666358688659e-07 / 2.6699938480633866e-07 / 2.004464466602968e-06 / 0.00014802121084993243 / 7.828884449821822e-06 | 0.003115691 | 7 |
| 6 | ARRB1_1 | 0.0000033954 | 0.0002804552471714009 / 0.0005780064318768233 / 0.010567003405101198 / 0.014937099801101831 / 0.01674887186117834 / 1.0437921127925209e-05 / 0.00023185717108361177 | 1.4696888618625038e-06 / 3.112710641578339e-05 / 1.247822961432111e-06 / 3.477116300776317e-06 / 0.00011575707789856708 / 0.0008336548513620248 / 0.0016450159858039666 | 0.00619339 | 7 |
| 7 | UBASH3B_1 | 0.0000018468 | 0.0002995789665935157 / 0.0040572780204219784 / 0.005622638162586019 / 0.0058415461692228185 / 0.012034946659617903 / 0.021088961594331778 / 0.01327523933544239 | 4.724411278108721e-08 / 4.074534670810025e-07 / 3.742229484811863e-08 / 1.929959476498321e-06 / 9.208079400238424e-07 / 1.5168095717056432e-05 / 0.00010044442526903786 | 0.008888598 | 7 |
| 8 | TNFRSF1A_2 | 0.0000000156 | 0.006712933497164321 / 0.00734125603680501 / 0.03443695791574148 / 0.018289424799019176 / 0.0009354534478970254 / 0.03357668476840166 / 0.007912796162920774 | 4.5437268485007956e-12 / 9.62085159236817e-09 / 5.689408914135723e-10 / 2.0274308401802066e-09 / 8.235496674010025e-08 / 1.2678212837654556e-05 / 8.896726535766315e-06 | 0.015600787 | 7 |
| 9 | FLT3_1 | 0.0000001451 | 0.003147802426563143 / 0.04222939169807093 / 0.02231188189092723 / 0.029744514791248327 / 0.028609215461963253 / 0.014219370494597181 / 0.014883090519715167 | 0.0012185301703030475 / 0.0002548917231763184 / 0.010959181924780034 / 2.4351732992736147e-06 / 5.5554978038046984e-05 / 0.0009499267638480247 / 0.013113311745609578 | 0.02216361 | 7 |
| 10 | TAF3_1 | 0.0000001041 | 1.571192550615105e-05 / 1.941083369182502e-05 / 0.0005612205331984135 / 0.0014877407788245077 / 5.841226151846549e-05 / 0.0007872693710314749 | 1.0270513426028016e-06 / 2.275418199134362e-06 / 5.376973880229442e-07 / 5.440513967426541e-05 / 4.007754879249793e-05 / 9.814569472587485e-06 | 0.000488294 | 6 |
| 11 | RNF169_1 | 0.0000003217 | 0.01436512323945228 / 0.0006014109163865767 / 0.0001378888342129313 / 0.0002929996205947111 / 0.007650609737897124 / 0.0005428574293301743 | 0.0010596490798711214 / 0.00033866528188749375 / 5.121947955378021e-05 / 5.927440166657884e-05 / 6.948929572951347e-06 / 2.3120988018089485e-05 | 0.003931815 | 6 |
| 12 | AGTRAP_1 | 0.0000023662 | 0.0027034438550029654 / 0.0016457734962318454 / 0.014533062562870484 / 0.02599605804689892 / 0.0024801934991487765 / 0.009546895754403102 | 1.646452812514797e-07 / 5.834785414810817e-09 / 2.228307124314093e-06 / 5.569491755748062e-05 / 2.3571084667936895e-07 / 0.0003782361834351102 | 0.009484238 | 6 |
| 13 | DDX60L_1 | 0.0000004163 | 0.008667427627946265 / 0.006966556160504672 / 0.002473974378703085 / 0.016468758578796875 / 0.004255262005017205 / 0.025751753175331515 | 2.1944492060454965e-10 / 8.933493156895685e-11 / 2.0506277272462366e-08 / 1.215047380695114e-10 / 7.747481723739867e-10 / 1.3299778330505356e-06 | 0.010763955 | 6 |
| 14 | MARCH9_1 | 0.0000028687 | 0.008696629436037122 / 0.015715958080688867 / 0.014693978334844182 / 0.007641325545186426 / 0.01903807829299923 / 0.02673662083221299 | 2.0837934472912685e-10 / 3.483396562503217e-08 / 4.9563854817943744e-06 / 1.1230784085451434e-07 / 4.956418832931685e-07 / 6.827219227535627e-05 | 0.015420432 | 6 |
| 15 | OSBPL5_1 | 0.0000008435 | 0.0261982361091171 / 0.030902579554522257 / 0.005200674803908244 / 0.01749894538092688 / 0.0006032976474312159 / 0.02092310744702267 | 5.453427993682317e-09 / 3.766985952770836e-07 / 1.2761924650567061e-06 / 7.72434990386913e-06 / 1.4070385044464016e-05 / 3.4211990088426983e-05 | 0.016887807 | 6 |
| 16 | ZNF22_1 | 0.0003669254 | 0.004371760349727022 / 0.0099226754908213 / 0.010321671240407263 / 0.011325776736179346 / 0.044537859106021475 / 0.025680963996521974 | 2.5184177279829715e-06 / 1.636959244332829e-05 / 9.28253424535522e-06 / 2.0181236604145942e-05 / 1.6154147530836813e-08 / 1.1540056394143666e-05 | 0.017693451 | 6 |
| 17 | DGAT1_3 | 0.0000000002 | 0.003920312673863002 / 0.033716279024290426 / 0.028856747132498983 / 0.001891302386162808 / 0.0334381808514423 / 0.04828281984464098 | 8.140369229025295e-09 / 5.289386858277019e-09 / 3.985757315136653e-06 / 1.144807405715584e-06 / 1.0254993066544188e-07 / 5.67274705848272e-07 | 0.025017607 | 6 |
| 18 | ORMDL3_2 | 0.0000000026 | 0.0001300233129794514 / 0.00012978314275476224 / 0.0012778350943993954 / 0.0029565776361184853 / 7.156767789831989e-05 | 4.677646164059941e-05 / 1.7503293191137602e-05 / 0.00021751510293843788 / 0.0007155675311678111 / 0.0004230167122498104 | 0.000913157 | 5 |
| 19 | ROPN1L_2 | 0.0000000992 | 0.0018394467371983382 / 0.00913487358238157 / 0.0049023855394268795 / 0.026316021782540434 / 0.0004368255106696828 | 1.65748500527577e-06 / 2.69948847247789e-06 / 3.4467469699377065e-06 / 8.914027666915662e-05 / 4.187857920242108e-05 | 0.008525911 | 5 |
| 20 | MSI2_1 | 0.0000007794 | 0.0002529667144490502 / 0.00036391652177154756 / 0.02345731242786629 / 0.019126121819567174 / 0.0033080493995101515 | 7.391397953437064e-07 / 4.9426454303194644e-08 / 1.2647772425190535e-05 / 1.2578560206261788e-05 / 0.0003891280853340393 | 0.009301673 | 5 |
| 21 | PSTPIP2_2 | 0.0000011641 | 0.01858959254693148 / 0.0057681381434131025 / 0.015399266745073165 / 0.01166420660727075 / 0.004242395710111552 | 6.507094545128767e-09 / 1.7105362633772053e-06 / 8.11163443332903e-09 / 8.384249213928925e-09 / 2.7206056643566975e-06 | 0.01113272 | 5 |
| 22 | MYL6B_1 | 0.0000017698 | 0.013119151423196779 / 0.012200296617999914 / 0.02306053904486267 / 0.011416714879054282 / 0.01303162671001627 | 1.3311228115309853e-10 / 2.1189280513945988e-08 / 2.608386936275246e-06 / 4.4163387400701993e-07 / 1.2403225638581886e-06 | 0.014565666 | 5 |
| 23 | LPAR6_2 | 0.0000010413 | 0.04483307027122483 / 0.016219042044394588 / 0.016746868284220093 / 0.00486964278014844 / 0.011545690725925754 | 3.55398091991154e-07 / 3.727072342882139e-06 / 8.612792966957608e-06 / 2.5049632841227237e-05 / 0.0002242378619733357 | 0.018842863 | 5 |
| 24 | RIPK2_5 | 0.0000090083 | 0.02265948210195236 / 0.035801285983055375 / 0.013949514732498905 / 0.03916661845542834 / 0.010906005384287334 | 2.1349289386986835e-07 / 6.970901169252273e-06 / 0.0001261364550401567 / 0.000139252106012186 / 0.0001754023039229962 | 0.024496581 | 5 |
| 25 | KIF15_1 | 0.0000003279 | 0.0001767131207877772 / 0.0020841717587245586 / 0.004354818985686167 / 0.003594625784570769 | 3.8166356839184545e-08 / 7.55812749192087e-08 / 8.424093350919768e-09 / 1.7417317886126239e-06 | 0.002552582 | 4 |
| 26 | ATP11A_2 | 0.0000000003 | 0.0020192776408069777 / 0.0014905987749008023 / 0.013592511172070427 / 0.011492354840434907 | 3.060704654994384e-08 / 1.3622595470762118e-06 / 1.1997422693515186e-05 / 2.3355709465331877e-05 | 0.007148686 | 4 |
| 27 | ZYX_1_9 | 0.0002544084 | 0.018753885801507886 / 0.005311083771261927 / 0.006409025340802752 / 0.005160774238426144 | 4.184364793482633e-08 / 2.790592162598525e-08 / 4.0166122353119465e-05 / 1.8565339769963503e-05 | 0.008908692 | 4 |
| 28 | SNRPG_5_5 | 0.0000089357 | 0.007921660193554354 / 0.02167583393151509 / 0.010388347521304256 / 0.004658316663498735 | 3.551868821203453e-05 / 0.00013168055697875434 / 6.548534863709185e-06 / 0.0005681263502070304 | 0.01116104 | 4 |
| 29 | RABGAP1_4_4 | 0.0000000240 | 9.003720907011053e-06 / 3.3390115236034044e-05 / 0.00010269468011156112 / 0.047149137178743444 | 2.8234052288359836e-11 / 1.0277712264139365e-09 / 4.49119651999139e-09 / 2.1963432700833613e-06 | 0.011823556 | 4 |
| 30 | AEBP1_5_4 | 0.0000000706 | 0.036562724183920495 / 0.0028825516275127186 / 0.00160056713944595 / 0.011492031900646014 | 1.9554526130426222e-07 / 1.552879261624138e-05 / 4.179984189724783e-07 / 8.30585388888977e-05 | 0.013134469 | 4 |
| 31 | HNRNPA0_5_7 | 0.0000000001 | 0.02460227458303824 / 0.004665409573481128 / 0.030772288525987988 / 0.001787886444312416 | 6.020361445492525e-07 / 1.741544026523412e-07 / 5.73570311140249e-07 / 6.770166211380507e-06 | 0.015456965 | 4 |
| 32 | PVRL2_1_15 | 0.0040605369 | 0.009602522264793944 / 0.009289808589253353 / 0.018424979456259774 / 0.024543614212947564 | 1.124934929019874e-11 / 8.232216311317465e-10 / 1.9664830084576235e-07 / 4.469619906576272e-09 | 0.015465231 | 4 |
| 33 | KIAA1377_1_4 | 0.0000081593 | 0.018039249363489208 / 0.024808081702847627 / 0.015360074710325671 / 0.006240332233062281 | 7.596479317713833e-09 / 6.788792995710976e-08 / 1.35168996872219e-07 / 2.1659140645524504e-08 | 0.016111935 | 4 |
| 34 | THEM4_5_4 | 0.0000000056 | 0.007883092210604252 / 0.045211602878352866 / 0.013149940565499176 / 0.005780083414189651 | 4.830559480901911e-08 / 7.6434613644282e-08 / 1.0166377279715499e-05 / 5.88015987182058e-07 | 0.01800618 | 4 |
| 35 | RBM15B_4_4 | 0.0000007681 | 0.0009381311035088946 / 0.03970456788745093 / 0.028253326379734534 / 0.006515747132785524 | 1.3038025544377534e-07 / 2.059062830566604e-07 / 4.983244116392506e-06 / 6.51433835861991e-05 | 0.018852943 | 4 |
| 36 | C10orf11_1_7 | 0.0003082937 | 0.02543028371249526 / 0.04598785527902361 / 0.015049388659828227 / 0.023622920144404418 | 7.259417399792894e-07 / 7.365037376695162e-06 / 2.047194651689395e-05 / 0.0002797495873085723 | 0.027522612 | 4 |
| 37 | NSMAF_1_7 | 0.0000032686 | 0.022251914845713937 / 0.04748951355240249 / 0.048345822890961225 / 0.01793479538407506 | 2.9254934132272395e-07 / 6.623060722446782e-06 / 5.831321946385646e-07 / 0.0022213483241615155 | 0.034005512 | 4 |
| 38 | FRAT2_2_9 | 0.0000008562 | 0.0469875036346009 / 0.03110964092628252 / 0.028109447152411662 / 0.04417620834797813 | 3.3044879183409916e-06 / 9.1345152872844e-06 / 8.429737657625968e-06 / 1.855611509886761e-05 | 0.0375957 | 4 |
| 39 | LRPAP1_2_3 | 0.0000000010 | 5.8572126941774705e-06 / 3.043966989607747e-06 / 4.7114539866525214e-06 | 1.9971265139787018e-07 / 8.389633993572189e-07 / 4.782132344940121e-05 | 4.53754E-06 | 3 |
| 40 | PRAM1_3_3 | 0.0000000000 | 7.723544457794067e-05 / 0.00043689278876896613 / 6.689338676878303e-05 | 0.00010570433563924172 / 0.007095334821012586 / 0.00012642089180450603 | 0.000193674 | 3 |
| 41 | RAG1_2_3 | 0.0000000001 | 0.0005257240065993557 / 0.0002394716728524391 / 0.0025629535017791943 | 5.592836211795487e-07 / 4.514859891307818e-06 / 0.00031448434878023827 | 0.001109383 | 3 |
| 42 | CARHSP1_2_3 | 0.0000000916 | 7.622564649516217e-05 / 0.0009833215694022874 / 0.0024720664729962283 | 2.124059305243635e-07 / 0.00011446446711497937 / 7.575581180621143e-05 | 0.001177205 | 3 |
| 43 | MBLAC1_1_3 | 0.0000002897 | 0.001629254700856046 / 0.007145353467565649 / 0.003740996699493107 | 2.6740655179081655e-06 / 5.483995787755592e-05 / 9.450515390044369e-06 | 0.004171868 | 3 |
| 44 | RAG2_3_4 | 0.0000000033 | 0.006629188877801916 / 0.0035201246516142408 / 0.007903236560929908 | 9.394932445113252e-06 / 6.847563888114024e-07 / 3.436655016403447e-06 | 0.006017517 | 3 |
| 45 | HNMT_1_4 | 0.0000109002 | 0.01445558317701132 / 0.002106973677295091 / 0.0051161594672994425 | 0.0009692764104023793 / 0.003012779171399397 / 0.0024376724564066005 | 0.007226239 | 3 |
| 46 | KCTD7_2_5 | 0.0000002604 | 0.020616294446739954 / 0.00021206125966908608 / 0.0009033836310563283 | 8.885033400689205e-08 / 2.389820509715415e-08 / 1.552864015973841e-06 | 0.007243913 | 3 |
| 47 | GSN_1_6 | 0.0000451573 | 0.018753885801507886 / 0.005160774238426144 / 0.005311083771261927 | 1.4722017530591616e-07 / 2.9874753250046506e-06 / 0.0002124927996391344 | 0.009741915 | 3 |
| 48 | CBFB_2_5 | 0.0000000001 | 0.003275583453177208 / 0.011330483320304221 / 0.01982909497763039 | 2.0245259136355526e-08 / 1.1456344413276593e-07 / 2.816265834361234e-06 | 0.011478387 | 3 |
| 49 | FBXO33_1_4 | 0.0000001371 | 0.0023176777492038073 / 0.0077384325604461434 / 0.028530012205593615 | 1.072142034599158e-06 / 5.345226496779758e-06 / 8.792028909123797e-05 | 0.012862041 | 3 |
| 50 | ZBED4_2_4 | 0.0000000002 | 0.00012909510564440324 / 0.027672452276552212 / 0.021025463475859662 | 9.434784549401446e-08 / 1.0143923768921633e-06 / 4.495391600951897e-06 | 0.01627567 | 3 |
| 51 | COPS8_5_6 | 0.0000043601 | 0.0031977499264920816 / 0.0058949672009652055 / 0.0415421191636228 | 6.858069673230018e-10 / 4.518917447441741e-08 / 2.2871232096910657e-06 | 0.016878279 | 3 |
| 52 | ISG20_1_12 | 0.0000001188 | 0.035870034304549374 / 0.006915099173258228 / 0.011599763066790982 | 4.0742030661470875e-09 / 3.5704180408306135e-05 / 2.6235380954232833e-06 | 0.018128299 | 3 |
| 53 | LGALS12_3_4 | 0.0000000247 | 0.003840056352113353 / 0.04492920892897124 / 0.006327629664955956 | 1.3156520171567348e-06 / 2.8564954858549742e-05 / 1.2400627667338633e-05 | 0.018365632 | 3 |
| 54 | SNRNP48_5_3 | 0.0000000018 | 0.010494026299769539 / 0.043808945731610247 / 0.0014402699590059412 | 2.99777252070361e-08 / 9.372440209809473e-07 / 1.6303080292790598e-06 | 0.018581081 | 3 |
| 55 | VPS37C_3_4 | 0.0000000002 | 0.015575058031697179 / 0.022954263288630178 / 0.019211836869592394 | 1.1893807531811264e-07 / 4.436107889122841e-07 / 2.596755422338286e-05 | 0.019247053 | 3 |
| 56 | ATP6V0A1_1_3 | 0.0000019232 | 0.000953280912166266 / 0.048984014938993056 / 0.009090139199551346 | 3.96290085102306e-06 / 5.2636828189880915e-05 / 2.713261376319351e-06 | 0.019675812 | 3 |
| 57 | HEATR5A_5_6 | 0.0000002878 | 0.007823565564916568 / 0.0292814900476121 / 0.02260169832848745 | 8.824452322000626e-09 / 8.736451088889874e-07 / 3.993788450977646e-06 | 0.019902251 | 3 |
| 58 | ENG_2_8 | 0.0000000000 | 0.03439309599730442 / 0.026001527500775657 / 0.0004074623263257791 | 3.7930066913887975e-05 / 2.6178770339186957e-06 / 3.208634906990993e-05 | 0.020267362 | 3 |
| 59 | USF1_5_7 | 0.0000000001 | 0.021841208862304992 / 0.020652548829715695 / 0.021917069763045867 | 7.175376098186409e-08 / 2.6998472948345092e-08 / 3.909927527606591e-07 | 0.021470276 | 3 |
| 60 | GRB10_2_11 | 0.0000185139 | 0.01872961470434043 / 0.02675787024949966 / 0.02145205112846333 | 1.2669785337002742e-06 / 3.145604382649769e-05 / 0.003268778879566519 | 0.022313179 | 3 |
| 61 | ZNF415_2_4 | 0.0000000549 | 0.034523433022212606 / 0.002626392249292539 / 0.03171232908110631 | 0.00011739915632689058 / 0.00032821497481615343 / 0.0006546049761514156 | 0.022954051 | 3 |
| 62 | DMTF1_1_4 | 0.0000031099 | 0.014324360736687866 / 0.014925670621200341 / 0.04696641107757261 | 1.4288355402449756e-08 / 1.4596250772642315e-06 / 5.309179790067734e-07 | 0.025405481 | 3 |
| 63 | MSL2_4_5 | 0.0000015252 | 0.037843536087373564 / 0.028245718557519638 / 0.010417492228432875 | 8.258866166846628e-08 / 0.0002798921759421857 / 1.2286864638985527e-05 | 0.025502249 | 3 |
| 64 | ATP7B_2_6 | 0.0000857095 | 0.019438518423424804 / 0.04009632870085458 / 0.019672456709775226 | 0.005743135091223456 / 0.0021129104763862407 / 0.00504181900162891 | 0.026402435 | 3 |
| 65 | MANBAL_1_5 | 0.0010263664 | 0.04759200231032889 / 0.013410196167242377 / 0.021153975401583373 | 0.0006029756140517701 / 0.00041293727100713963 / 0.0005679619453748995 | 0.027385391 | 3 |
| 66 | STOX1_1_3 | 0.0000006884 | 0.03863925234050396 / 0.03290414475660668 / 0.03755706426028869 | 3.498492394676035e-07 / 3.760551753407323e-07 / 2.1838711309964997e-05 | 0.03636682 | 3 |
| 67 | PRKCB_2_4 | 0.0036722126 | 0.03636552435344791 / 0.0455393445167841 / 0.028719427176232087 | 0.0017342974389574256 / 0.0002954473217666082 / 0.0019265906505422808 | 0.036874765 | 3 |
| 68 | PNPLA8_3_5 | 0.0007762216 | 0.042906002207961834 / 0.03376346011476386 / 0.04533268492631154 | 1.8682120741176118e-07 / 3.889932908773882e-08 / 9.103372671114004e-06 | 0.040667382 | 3 |
| 69 | ACCS_3_2 | 0.0000000228 | 0.001351396866557077 / 0.0010059530260990539 | 4.958979360917343e-05 / 0.0023766001705639063 | 0.001178675 | 2 |
| 70 | BANP_1_2 | 0.0000005192 | 0.0019949596708715915 / 0.0016405254782622762 | 1.8954349923575262e-08 / 2.9663347375425656e-07 | 0.001817743 | 2 |
| 71 | ARID1A_2_3 | 0.0000370373 | 0.0002225245598561803 / 0.003462048449780649 | 2.8835181082720374e-06 / 8.852299874117299e-06 | 0.001842287 | 2 |
| 72 | ELOVL5_1_4 | 0.0000080768 | 0.0039737550720910855 / 0.0005677614392890738 | 1.767738685972929e-05 / 5.339450136972672e-05 | 0.002270758 | 2 |
| 73 | N4BP2_5_2 | 0.0000006959 | 0.0015260933937112297 / 0.0030693630789256784 | 8.782349802931962e-08 / 1.8514757097012648e-06 | 0.002297728 | 2 |
| 74 | LIMS2_5_3 | 0.0000000063 | 0.0016929672723561087 / 0.008211724439767342 | 0.0016526205911910397 / 0.00010998980798238088 | 0.004952346 | 2 |
| 75 | DPCD_1_2 | 0.0001195622 | 0.010348808383695646 / 0.0010576116241639605 | 3.4139161518097934e-06 / 5.8072556519062024e-05 | 0.00570321 | 2 |
| 76 | KATNB1_5_2 | 0.0000003099 | 0.0019502509185472647 / 0.011870363561574568 | 6.469316636849928e-07 / 1.4319474206641112e-06 | 0.006910307 | 2 |
| 77 | RBM18_1_3 | 0.0000183263 | 0.01202180554894753 / 0.0035996788619062025 | 2.314655750329529e-05 / 1.6273301545995376e-05 | 0.007810742 | 2 |
| 78 | EWSR1_1_2 | 0.0000001571 | 0.012034946659617903 / 0.0040572780204219784 | 4.353930633746647e-07 / 1.4940958130887165e-07 | 0.008046112 | 2 |
| 79 | SDC4_1_5 | 0.0234952285 | 0.012910722002948388 / 0.003241368623522047 | 0.0023789084931403904 / 2.15445169218155e-05 | 0.008076045 | 2 |
| 80 | LCK_5_3 | 0.0000000635 | 0.008161592461102153 / 0.008111725160704844 | 5.0045516393587565e-08 / 2.5329814927720417e-06 | 0.008136659 | 2 |
| 81 | GNA15_1_9 | 0.0000088925 | 0.0025023165322416653 / 0.015816246241733566 | 1.2297735264773097e-09 / 2.212465069137835e-05 | 0.009159281 | 2 |
| 82 | S1PR2_2_8 | 0.0000000000 | 0.019132559438094155 / 3.0373671784422295e-05 | 8.259862596669298e-06 / 3.850434675370876e-06 | 0.009581467 | 2 |
| 83 | SOX4_2_2 | 0.0000001046 | 0.0027896864342722566 / 0.018314702453390137 | 1.3593400126131383e-06 / 3.4858545482237707e-06 | 0.010552194 | 2 |
| 84 | MPP1_1_19 | 0.0000010744 | 0.0025023165322416653 / 0.019031746930740782 | 6.468408975112741e-07 / 4.501092888023762e-06 | 0.010767032 | 2 |
| 85 | TRIM26_1_5 | 0.0000259348 | 0.005311083771261927 / 0.018753885801507886 | 2.1060691141971387e-05 / 8.874237350648491e-05 | 0.012032485 | 2 |
| 86 | NRN1_2_2 | 0.0000003469 | 0.011538246690417763 / 0.013237230739493226 | 4.568675707352792e-05 / 3.561238367689432e-05 | 0.012387739 | 2 |
| 87 | PHACTR2_1_4 | 0.0000005718 | 0.023477467429053465 / 0.0031820555262817535 | 8.883753710042578e-09 / 3.719669014236788e-08 | 0.013329761 | 2 |
| 88 | TRAF3IP2_2_2 | 0.0000002512 | 0.0007576193165839696 / 0.027287848272635487 | 6.910884434287362e-05 / 0.0005161273618227694 | 0.014022734 | 2 |
| 89 | MLF1IP_1_2 | 0.0000000269 | 0.01425257865031356 / 0.013908722253004258 | 2.3242551216769015e-07 / 2.032446141420201e-07 | 0.01408065 | 2 |
| 90 | PELI2_5_7 | 0.0000007941 | 0.024350309684056323 / 0.0040259990419718224 | 1.6694115297250117e-05 / 4.29829826110023e-06 | 0.014188154 | 2 |
| 91 | HNRNPA1L2_1_2 | 0.0013250663 | 0.011811366692668503 / 0.01996564314234407 | 6.032224635469657e-06 / 0.00022917080156904956 | 0.015888505 | 2 |
| 92 | BCL11B_5_3 | 0.0000002152 | 0.0010839847636384084 / 0.0314544685608876 | 1.5333271595229285e-05 / 5.898660325189134e-05 | 0.016269227 | 2 |
| 93 | TTF1_5_6 | 0.0000000000 | 0.029170441459925932 / 0.005632866448663831 | 5.197029616318252e-06 / 3.552041331603543e-05 | 0.017401654 | 2 |
| 94 | SKA3_1_2 | 0.0000017003 | 0.02944327994687945 / 0.006711372368467916 | 7.293595674464534e-07 / 6.073859065512907e-06 | 0.018077326 | 2 |
| 95 | ECI1_1_2 | 0.0000229019 | 0.035232086909202764 / 0.004224402787232246 | 0.0006535889942974735 / 1.0760030207436584e-05 | 0.019728245 | 2 |
| 96 | LAPTM4B_1_8 | 0.0005057964 | 0.038858943917955066 / 0.0026332591769253765 | 8.316897145333996e-07 / 0.0026794799237590664 | 0.020746102 | 2 |
| 97 | C11orf74_4_5 | 0.0000166404 | 0.0065634419527186095 / 0.035907170503621015 | 2.3323526700006173e-07 / 3.9706288089173614e-08 | 0.021235306 | 2 |
| 98 | RNF24_1_12 | 0.0000007106 | 0.035870034304549374 / 0.006915099173258228 | 7.35322340702987e-10 / 2.1643712587488395e-06 | 0.021392567 | 2 |
| 99 | CRB3_1_4 | 0.0001229934 | 0.0007511098393260164 / 0.04383341877435241 | 0.003519521269349817 / 0.00041067349827126156 | 0.022292264 | 2 |
| 100 | CNTROB_5_3 | 0.0000000247 | 0.039985574714404205 / 0.006604515441249478 | 2.807079453207472e-06 / 6.0843943238096606e-06 | 0.023295045 | 2 |
| 101 | KIAA1967_5_2 | 0.0000000000 | 0.03731581709317308 / 0.012775853621628915 | 5.8098057666508814e-05 / 1.4846660294438575e-05 | 0.025045835 | 2 |
| 102 | KRT10_1_3 | 0.0000036294 | 0.0026276752303615626 / 0.04816709797976521 | 2.3292547237816868e-07 / 1.1196213690475162e-05 | 0.025397387 | 2 |
| 103 | VIT_1_2 | 0.0000022102 | 0.029787982806896113 / 0.032221265722000465 | 0.00017866575515019837 / 0.0002927226669085562 | 0.031004624 | 2 |
| 104 | TMEM173_2_7 | 0.0000013775 | 0.04752560036471882 / 0.021645143900361517 | 9.96917291837022e-10 / 3.7449827724309687e-05 | 0.034585372 | 2 |
| 105 | SGCB_1_3 | 0.0000001520 | 0.04565488150522094 / 0.02362203677270414 | 1.1745686994413256e-07 / 2.146978330026032e-06 | 0.034638459 | 2 |
| 106 | DTD1_3_4 | 0.0000046923 | 0.04395039131441785 / 0.025938330717151792 | 2.2711346209436874e-06 / 5.0656566660967563e-05 | 0.034944361 | 2 |
| 107 | DYSF_1_3 | 0.0000126202 | 0.0339445086192224 / 0.03749998396549492 | 1.097257076002153e-06 / 3.4300052428458304e-05 | 0.035722246 | 2 |
| 108 | AP2S1_1_3 | 0.0000000192 | 0.04966114977300441 / 0.025208249293274098 | 9.67952519324101e-06 / 5.812467299823981e-06 | 0.0374347 | 2 |
| 109 | EMILIN2_1_11 | 0.0000004298 | 0.035870034304549374 / 0.04080808705746035 | 3.9151610584341596e-05 / 0.0034531579985310175 | 0.038339061 | 2 |
| 110 | SLC38A1_1_6 | 0.0000051639 | 0.04291927548525659 / 0.04100450439141127 | 0.00021587157297136373 / 7.315015547583871e-06 | 0.04196189 | 2 |
| 111 | SGSM2_4_1 | 0.0000000000 | 1.8562520247073517e-06 | 1.2613994263920118e-05 | 1.85625E-06 | 1 |
| 112 | ADAM15_1_1 | 0.0000043982 | 2.1108944769046428e-05 | 4.681342411309229e-05 | 2.11089E-05 | 1 |
| 113 | JPH1_2_1 | 0.0000000278 | 7.575574348900015e-05 | 3.941680513177924e-06 | 7.57557E-05 | 1 |
| 114 | S100A8_1_3 | 0.0000014212 | 0.00016898721560974943 | 0.00029401372690121037 | 0.000168987 | 1 |
| 115 | SQSTM1_2_1 | 0.0000005259 | 0.00017867345021532058 | 9.669186962307088e-08 | 0.000178673 | 1 |
| 116 | ANXA2_1_1 | 0.0002075934 | 0.0006183619071556604 | 6.009170462268738e-07 | 0.000618362 | 1 |
| 117 | CMBL_1_2 | 0.0000903757 | 0.0006632986409284882 | 0.0009716339098724625 | 0.000663299 | 1 |
| 118 | CABLES2_1_1 | 0.0000005356 | 0.0009735838558541434 | 1.5864345356463386e-06 | 0.000973584 | 1 |
| 119 | NDST3_2_1 | 0.0001935195 | 0.0013385816312795275 | 0.004242951596879371 | 0.001338582 | 1 |
| 120 | LMNA_1_1 | 0.0001346708 | 0.0013680275764369084 | 1.8919816110190497e-07 | 0.001368028 | 1 |
| 121 | SP1_5_1 | 0.0000000097 | 0.0016246578528363023 | 0.003568784039880526 | 0.001624658 | 1 |
| 122 | CDCA7_1_2 | 0.0000002357 | 0.001651752731778548 | 3.2201603349527115e-08 | 0.001651753 | 1 |
| 123 | NFYB_1_1 | 0.0000079306 | 0.001651752731778548 | 2.9900676055211447e-06 | 0.001651753 | 1 |
| 124 | SLFN5_2_1 | 0.0000000019 | 0.0019030049715582106 | 1.6941578744438862e-06 | 0.001903005 | 1 |
| 125 | CREG1_3_1 | 0.0000000008 | 0.002054415410594919 | 7.20016447767814e-08 | 0.002054415 | 1 |
| 126 | DAD1_1_1 | 0.0000006548 | 0.0023044700596710713 | 2.075870685180039e-05 | 0.00230447 | 1 |
| 127 | SURF4_1_4 | 0.0001169460 | 0.0023462063828761834 | 2.694050289871364e-06 | 0.002346206 | 1 |
| 128 | CDK6_1_1 | 0.0000006851 | 0.0025023165322416653 | 4.988905197611986e-08 | 0.002502317 | 1 |
| 129 | TBCD_5_1 | 0.0000000036 | 0.002561276140915946 | 2.9892584316614904e-05 | 0.002561276 | 1 |
| 130 | FLRT3_1_1 | 0.0002800458 | 0.002583315109010803 | 5.49167223817782e-07 | 0.002583315 | 1 |
| 131 | FUCA2_2_1 | 0.0000025095 | 0.002692404935612982 | 1.2127488828322545e-08 | 0.002692405 | 1 |
| 132 | MAPK7_1_1 | 0.0000080829 | 0.0027910840567973052 | 3.572472659968713e-06 | 0.002791084 | 1 |
| 133 | IER3_1_1 | 0.0000013686 | 0.003048257034885675 | 4.950876200499383e-07 | 0.003048257 | 1 |
| 134 | U2AF1_1_1 | 0.0000711501 | 0.0034457838678580263 | 4.61837154254303e-05 | 0.003445784 | 1 |
| 135 | PLA2G12A_1_3 | 0.0000038708 | 0.0037441061510198473 | 2.729672667763293e-06 | 0.003744106 | 1 |
| 136 | CBX2_2_1 | 0.0000000018 | 0.004184305915812207 | 5.9615623663426e-06 | 0.004184306 | 1 |
| 137 | MGAT4A_5_1 | 0.0000000380 | 0.004222683731586138 | 8.335124351148404e-06 | 0.004222684 | 1 |
| 138 | STARD10_1_1 | 0.0000111851 | 0.004248732743058664 | 1.7842777216078496e-05 | 0.004248733 | 1 |
| 139 | CSRNP2_1_1 | 0.0006867668 | 0.004513557106243546 | 0.0027185421381640293 | 0.004513557 | 1 |
| 140 | DOK2_2_1 | 0.0000003678 | 0.004572328568472603 | 1.1556890898941218e-07 | 0.004572329 | 1 |
| 141 | VOPP1_1_1 | 0.0000001536 | 0.004906926404956519 | 6.909057066591582e-07 | 0.004906926 | 1 |
| 142 | PLOD1_1_1 | 0.0000003727 | 0.005173685415892114 | 3.142318025848709e-07 | 0.005173685 | 1 |
| 143 | C3AR1_1_1 | 0.0000020129 | 0.005257465843641482 | 2.3396828250233102e-05 | 0.005257466 | 1 |
| 144 | CYSLTR1_1_1 | 0.0000173361 | 0.005311083771261927 | 4.033605569704644e-05 | 0.005311084 | 1 |
| 145 | S100A6_1_1 | 0.0000725809 | 0.005362813680576461 | 5.537142752723009e-07 | 0.005362814 | 1 |
| 146 | ZADH2_1_1 | 0.0000007439 | 0.005446188106227207 | 4.5754730268930877e-07 | 0.005446188 | 1 |
| 147 | EXOSC9_5_2 | 0.0000000031 | 0.005557108169871316 | 0.0008987664165136352 | 0.005557108 | 1 |
| 148 | ZC3H4_2_1 | 0.0000015162 | 0.0056341770524356806 | 2.473933719190643e-06 | 0.005634177 | 1 |
| 149 | BARD1_1_2 | 0.0001823376 | 0.006165167235416857 | 1.190027150355448e-06 | 0.006165167 | 1 |
| 150 | MCL1_1_1 | 0.0000001874 | 0.007100868378374273 | 4.0192784636893195e-10 | 0.007100868 | 1 |
| 151 | NINL_3_4 | 0.0002849953 | 0.0075283603267041295 | 0.00041052511652349915 | 0.00752836 | 1 |
| 152 | HYI_5_1 | 0.0000017676 | 0.0075586596774093046 | 1.819350673029577e-06 | 0.00755866 | 1 |
| 153 | USP49_1_1 | 0.0001312429 | 0.008755239263851211 | 3.964656691897526e-06 | 0.008755239 | 1 |
| 154 | EPB41_1_3 | 0.0001006328 | 0.009034882970510456 | 0.00013511214683115084 | 0.009034883 | 1 |
| 155 | NFAM1_1_1 | 0.0022752255 | 0.00930978531173234 | 0.002292669227147625 | 0.009309785 | 1 |
| 156 | SIVA1_5_1 | 0.0000000190 | 0.00976422285866606 | 7.911319869760405e-07 | 0.009764223 | 1 |
| 157 | LRG1_1_2 | 0.0000001990 | 0.009927973270752382 | 2.608540917049233e-06 | 0.009927973 | 1 |
| 158 | TMPRSS15_1 | 0.0006841749 | 0.01024047346065129 | 0.0015664204162032947 | 0.010240473 | 1 |
| 159 | G0S2_1 | 0.0000299702 | 0.010257439205265872 | 8.408868136136204e-05 | 0.010257439 | 1 |
| 160 | PPIP5K2_2 | 0.0000000004 | 0.010428331358146754 | 3.5879660652504166e-05 | 0.010428331 | 1 |
| 161 | AGPAT3_4 | 0.0000001930 | 0.012409468524965496 | 5.951529459390704e-06 | 0.012409469 | 1 |
| 162 | AS3MT_5 | 0.0000000636 | 0.012507967443150024 | 5.2069842035903486e-05 | 0.012507967 | 1 |
| 163 | PIK3R3_1 | 0.0000004378 | 0.012693846370002933 | 1.1134112040621844e-05 | 0.012693846 | 1 |
| 164 | CRY1_2 | 0.0000000015 | 0.01273908719327046 | 1.0364125026792716e-05 | 0.012739087 | 1 |
| 165 | ZNF367_1 | 0.0000007429 | 0.012817165427214991 | 1.6554871434804345e-06 | 0.012817165 | 1 |
| 166 | CAV2_3 | 0.0000900165 | 0.013003562519067686 | 0.0003165314040118799 | 0.013003563 | 1 |
| 167 | PRKAR2A_5 | 0.0000000095 | 0.01304625461905942 | 1.165198476893287e-06 | 0.013046255 | 1 |
| 168 | CDH3_1 | 0.0045171197 | 0.013410196167242377 | 0.0007156791563689302 | 0.013410196 | 1 |
| 169 | PCYOX1L_1 | 0.0000134838 | 0.013753446987297501 | 1.9648507707958793e-05 | 0.013753447 | 1 |
| 170 | RNF13_1 | 0.0000015479 | 0.01425257865031356 | 1.4173074929245687e-06 | 0.014252579 | 1 |
| 171 | CD7_2 | 0.0000009350 | 0.01439564075722508 | 7.429143195372626e-05 | 0.014395641 | 1 |
| 172 | ZDHHC20_2 | 0.0001740391 | 0.015206312141533855 | 4.602813943558735e-05 | 0.015206312 | 1 |
| 173 | LGALS3_1 | 0.0000060213 | 0.015392940222320921 | 1.0628836539660367e-05 | 0.01539294 | 1 |
| 174 | FANCD2_1 | 0.0000121545 | 0.015451637722969586 | 1.8831841564871015e-06 | 0.015451638 | 1 |
| 175 | TLX2_1 | 0.0000038270 | 0.01579251142156246 | 0.00030858470095783614 | 0.015792511 | 1 |
| 176 | IFT122_1 | 0.0000002512 | 0.015816246241733566 | 1.0290413092804304e-06 | 0.015816246 | 1 |
| 177 | ZNF423_5 | 0.0000000005 | 0.01687645691903394 | 6.82889444974133e-05 | 0.016876457 | 1 |
| 178 | KDELR1_2 | 0.0000093509 | 0.017039557735435966 | 0.0033303362491578807 | 0.017039558 | 1 |
| 179 | UFM1_1 | 0.0000305210 | 0.01740310378263097 | 1.2418583024568846e-07 | 0.017403104 | 1 |
| 180 | ANKRD22_1 | 0.0041854861 | 0.018007630833331033 | 0.03752163881197765 | 0.018007631 | 1 |
| 181 | PLAGL1_3 | 0.0000021368 | 0.018069182178099105 | 3.851073571966146e-09 | 0.018069182 | 1 |
| 182 | ZAP70_5 | 0.0000000009 | 0.018364208164662808 | 6.653729445177915e-06 | 0.018364208 | 1 |
| 183 | OSBPL11_3 | 0.0000067843 | 0.018433344261519963 | 9.808098956813373e-09 | 0.018433344 | 1 |
| 184 | TSPAN7_2 | 0.0004599184 | 0.018664165174459613 | 0.0021706260770740027 | 0.018664165 | 1 |
| 185 | SPAG7_1 | 0.0000103437 | 0.01887978871098741 | 3.5786939909329174e-07 | 0.018879789 | 1 |
| 186 | ABCB10_1 | 0.0000008268 | 0.019394963522372948 | 7.395897405399312e-06 | 0.019394964 | 1 |
| 187 | WDR83_4 | 0.0000057993 | 0.019553853323608723 | 0.0007136717421366572 | 0.019553853 | 1 |
| 188 | SLC25A29_5 | 0.0000000015 | 0.019638512683722072 | 9.869448477453816e-08 | 0.019638513 | 1 |
| 189 | SGPP1_1 | 0.0000025587 | 0.020929857770881414 | 2.0298643448524998e-06 | 0.020929858 | 1 |
| 190 | CD59_1 | 0.0000068828 | 0.021559533703573927 | 0.001648922456290617 | 0.021559534 | 1 |
| 191 | MRPS21_5 | 0.0077373847 | 0.021700322664243165 | 9.63985905023122e-07 | 0.021700323 | 1 |
| 192 | ILF2_1 | 0.0000000252 | 0.02183529105408133 | 3.091305085273976e-06 | 0.021835291 | 1 |
| 193 | NRM_1 | 0.0002687490 | 0.022253050272657 | 2.0382718096255757e-09 | 0.02225305 | 1 |
| 194 | FEM1C_1 | 0.0000014517 | 0.02227664632042583 | 8.589759094000804e-06 | 0.022276646 | 1 |
| 195 | PRCP_1 | 0.0000000056 | 0.0230304550081597 | 2.1961723373343916e-07 | 0.023030455 | 1 |
| 196 | P4HB_1 | 0.0000003568 | 0.02341318363108619 | 2.8084943956360846e-10 | 0.023413184 | 1 |
| 197 | CD44_1 | 0.0000359903 | 0.023548564177701903 | 1.6066512112185574e-09 | 0.023548564 | 1 |
| 198 | DCTN4_1 | 0.0013385549 | 0.024489122777067992 | 0.019368696851182407 | 0.024489123 | 1 |
| 199 | YIPF5_1 | 0.0000060349 | 0.026730236331654417 | 1.0541687156357308e-06 | 0.026730236 | 1 |
| 200 | AGPAT2_1 | 0.0000002107 | 0.026889530537036167 | 1.7713923094852022e-07 | 0.026889531 | 1 |
| 201 | FAM136A_1 | 0.0006422807 | 0.028051819441664617 | 0.002488725830315593 | 0.028051819 | 1 |
| 202 | TSPAN32_5 | 0.0000000000 | 0.02866197022141713 | 5.259717320638688e-06 | 0.02866197 | 1 |
| 203 | PLA2G16_1 | 0.0003081786 | 0.02897405027367459 | 2.0665812391610075e-06 | 0.02897405 | 1 |
| 204 | MET_2 | 0.0000285645 | 0.030192710022355414 | 0.00379589859681431 | 0.03019271 | 1 |
| 205 | TMEM97_1 | 0.0036145788 | 0.03026262122509119 | 0.00021306559827421171 | 0.030262621 | 1 |
| 206 | ZNF839_1 | 0.0000001711 | 0.030726289078901264 | 1.5879232684994666e-05 | 0.030726289 | 1 |
| 207 | ERMAP_4 | 0.0001168108 | 0.031146240127524386 | 6.298967979200791e-05 | 0.03114624 | 1 |
| 208 | TMEM150A_1 | 0.0000043452 | 0.03197682912178042 | 1.628398621899164e-05 | 0.031976829 | 1 |
| 209 | PDIA5_1 | 0.0000034458 | 0.03351303270628667 | 2.3191823260124111e-10 | 0.033513033 | 1 |
| 210 | CLIP1_3 | 0.0000001166 | 0.03429726403676071 | 4.469910794620894e-06 | 0.034297264 | 1 |
| 211 | NUDT2_1 | 0.0000159662 | 0.034635799638304134 | 1.3986302087232156e-05 | 0.0346358 | 1 |
| 212 | SMYD2_1 | 0.0000077856 | 0.03730228706011286 | 1.2971961011563423e-05 | 0.037302287 | 1 |
| 213 | TMPO_1 | 0.0000008966 | 0.03798708635473315 | 9.272936461577683e-05 | 0.037987086 | 1 |
| 214 | ZC4H2_5 | 0.0000000001 | 0.03821396773041524 | 3.364502202047952e-05 | 0.038213968 | 1 |
| 215 | TXLNB_1 | 0.0063084330 | 0.038858943917955066 | 3.4406524050829844e-08 | 0.038858944 | 1 |
| 216 | CHID1_3 | 0.0000000038 | 0.038921368031173256 | 1.7696631517095603e-08 | 0.038921368 | 1 |
| 217 | TBXAS1_2 | 0.0001000498 | 0.03912053365002339 | 0.00017683963886805498 | 0.039120534 | 1 |
| 218 | KLHL25_5 | 0.0000000143 | 0.04196676056691442 | 1.7560089108082686e-05 | 0.041966761 | 1 |
| 219 | CSF3R_5 | 0.0000000304 | 0.04250513375736285 | 0.00017631047010437925 | 0.042505134 | 1 |
| 220 | SEPHS1_1 | 0.0000222248 | 0.0450636464624055 | 6.469551154776827e-06 | 0.045063646 | 1 |
| 221 | TRAT1_3 | 0.0000000000 | 0.04551857731992099 | 0.00013370660602496452 | 0.045518577 | 1 |
| 222 | BET1_1 | 0.0000000254 | 0.0465608957106569 | 1.9024554960722768e-07 | 0.046560896 | 1 |
| 223 | ZNF238_1 | 0.0000006050 | 0.046847268071909955 | 7.35354402710928e-05 | 0.046847268 | 1 |
| 224 | BST1_1 | 0.0000370830 | 0.04931613832873068 | 0.0025410513361841546 | 0.049316138 | 1 |
| 225 | CITED4_1 | 0.0000331218 | 0.04931613832873068 | 5.1719881815858375e-05 | 0.049316138 | 1 |
[표 4]에는 여성암(breast, ovary) 약물에 연관된 FRH 들과, 이와 연관된 여성암 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 5] 에는 [표 4]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(Pvlaue)값을 의미하는 것으로, [표 4]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 4]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 여성암 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 27에는 표 4에 기재된 바이오마커들 중 주요 바이오마커들의 여성암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 28에는 주요 바이오마커들에 의해 발현된 유전자들과 여성암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Drug | DrugType | Var(마커) |
| 1 | IRX5_3 | 1526_RDEA119 (rescreen) / 1242_(5Z)-7-Oxozeaenol / 1372_Trametinib / 1498_AZD6244 / 1014_RDEA119 / 1378_Bleomycin(50uM) / 1005_Cisplatin / 1019_Bosutinib / 165_DMOG / 1015_CI-1040 / 1020_Lenalidomide / 1371_PLX4720(rescreen) / 155_AP-24534 / 1062_AZD6244 / 1495_Olaparib / 1006_Cytarabine / 1060_PD-0325901 / 1013_Nilotinib / 1018_ABT-888 / 1268_XAV 939 / 1003_Camptothecin / 262_VX-11e / 1037_BX-795 / 1024_CEP-701 / 1017_Olaparib / 1243_piperlongumine / 1022_AZD7762 / 1375_Temozolomide / 1043_JNK Inhibitor VIII / 226_GSK1070916 / 228_KIN001-102 / 1091_BMS-536924 / 308_XL-880 / 1264_SGC0946 / 1494_SN-38 | erk_mapk / other / erk_mapk / erk_mapk / erk_mapk / DNArep / DNArep / abl / other / erk_mapk / other / erk_mapk / abl / erk_mapk / g_integrity / DNArep / erk_mapk / abl / g_integrity / wnt / DNArep / erk_mapk / other / rtk / g_integrity / other / g_integrity / DNArep / jnk_p38 / mitosis / pi3k / igfr / rtk / chromatin / DNArep | 1_13248174_T_C / 16_85071785_A_G / 9_34371054_A_C |
| 2 | IRX5_1 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 155_Ponatinib_2 / 1378_Bleomycin(50uM)_1 / 165_DMOG_3 / 1014_Refametinib_2 / 1242_(5Z)-7-Oxozeaenol_3 / 159_HG6-64-1_3 | erk_mapk / erk_mapk / erk_mapk / abl / DNArep / other / erk_mapk / other / erk_mapk | 1_13248174_T_C |
| 3 | CMIP_1 | 1526_Refametinib_3 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1378_Bleomycin(50uM)_1 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / DNArep | 16_85071785_A_G |
| 4 | PREX1_1 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 155_Ponatinib_2 / 1015_CI-1040_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk | 9_34371054_A_C |
| 5 | HIST1H2BK_1 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 | erk_mapk / erk_mapk / erk_mapk | 6_132814681_A_G |
| 6 | SERPINE1_2 | 1498_Selumetinib_2 / 1526_Refametinib_3 / 1014_Refametinib_2 | erk_mapk / erk_mapk / erk_mapk | 1_17240836_G_T / X_156025548_C_T |
| 7 | SGTB_1 | 1242_(5Z)-7-Oxozeaenol_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 | other / erk_mapk / erk_mapk | 9_74785802_T_C |
| 8 | XYLT2_1 | 1022_AZD7762_2 / 1378_Bleomycin(50uM)_1 | g_integrity / DNArep | 2_206056727_G_A |
| 9 | SOGA2_1 | 155_Ponatinib_2 / 1378_Bleomycin(50uM)_1 | abl / DNArep | 3_51980957_A_C |
| 10 | ZC3H12C_1 | 1378_Bleomycin(50uM)_1 / 1014_Refametinib_2 | DNArep / erk_mapk | 20_18452633_T_G |
| 11 | AFAP1L2_1 | 1526_Refametinib_3 / 1014_Refametinib_2 | erk_mapk / erk_mapk | 2_39717176_T_G |
| 12 | CHRNA5_1 | 134_Etoposide_1 / 295_NVP-BHG712_3 | DNArep / rtk | 3_196708735_G_GA |
| 13 | ASGR2_1 | 1024_Lestauritinib_2 / 1014_Refametinib_2 | rtk / erk_mapk | 10_38696926_C_T |
| 14 | RHBDL2_5 | 1114_Cetuximab_1 | egfr | 15_40896089_A_G / 15_40900360_T_C / 5_150068208_G_A / 10_132859105_C_T / 10_132860307_C_T |
| 15 | TMEM206_3 | 252_WZ3105_3 | other | 2_108378352_C_G / 14_106335417_A_C / 14_106360128_A_C |
| 16 | SUPT4H1_1 | 1022_AZD7762_2 | g_integrity | 11_114444466_A_G |
| 17 | LRTOMT_1 | 1022_AZD7762_2 | g_integrity | 19_10162649_G_A |
| 18 | EME2_1 | 1378_Bleomycin(50uM)_1 | DNArep | 7_108180467_G_T |
| 19 | TMEM158_1 | 1241_CHIR-99021_3 | wnt | 17_60211179_G_A |
| 20 | EFS_1 | 1242_(5Z)-7-Oxozeaenol_3 | other | 19_30444797_C_A |
| 21 | CA5B_1 | 1378_Bleomycin(50uM)_1 | DNArep | 9_133696445_G_T |
| 22 | SDC1_1 | 1032_Afatinib_1 | egfr | 14_70246869_T_G |
| 23 | QSER1_1 | 226_GSK1070916_2 | mitosis | 13_79521022_A_T |
| 24 | GALNTL5_2 | 1012_Vorinostat_1 | chromatin | 15_34255437_A_T / 10_100352318_A_G |
| 25 | JAG1_5 | 1378_Bleomycin(50uM)_1 | DNArep | 3_122558313_G_T / 3_122558325_G_A / 3_122552357_T_TA / 3_122461164_C_G / 8_138636921_T_C |
| 26 | SOAT1_1 | 1022_AZD7762_2 | g_integrity | 7_108180467_G_T |
| 27 | BIRC2_1 | 231_FMK_3 | erk_mapk | 11_8101385_C_A |
| 28 | NAALADL2_1 | 1019_Bosutinib_1 | abl | 1_78893077_T_G |
| 29 | RGS2_1 | 1372_Trametinib_1 | erk_mapk | 18_12978734_C_G |
| 30 | PRR12_1 | 326_GSK690693_3 | pi3k | 6_38813973_C_T |
| 31 | AXL_2 | 1006_Cytarabine_1 | DNArep | 17_60211184_A_G / 5_224282_A_G |
| 32 | C6orf203_3 | 193_GW-2580_3 | rtk | 2_135390832_A_T / 17_48076840_A_G / 2_135230616_G_A |
| 33 | RNF208_2 | 255_CP724714_2 | egfr | 19_11832898_G_A / 4_7815971_GT_G |
| 34 | TNFRSF21_1 | 155_Ponatinib_2 | abl | 20_8802237_G_A |
| 35 | MAP6_1 | 29_AZ628_3 | erk_mapk | 7_6149477_GA_G |
| 36 | ABLIM1_1 | 1020_Lenalidomide_1 / 1017_Olaparib_2 / 1016_Temsirolimus_1 / 1170_CCT-018159_3 / 1004_Vinblastine_1 / 1033_Vismodegib_2 | other / g_integrity / tor / other / cytoskeleton / other | 4_70158293_T_TACAA |
| 37 | DIAPH1_5 | 1069_EHT-1864_3 / 222_BX-912_3 | cytoskeleton / pi3k | 7_73180651_C_T / 7_75212025_G_A / 7_74734035_C_T / 13_31758155_C_G / 7_72961358_G_A |
| 38 | FBXO10_5 | 222_BX-912_3 / 1008_Methotrexate_1 | pi3k / DNArep | 7_73180651_C_T / 7_75212025_G_A / 17_63918839_T_A / 7_72961358_G_A / 7_75403732_C_T |
| 39 | OLR1_1 | 1218_JQ1_3 | chromatin | 22_39017940_A_C |
| 40 | ADK_1 | 1001_AICA_Ribonucleotide_2 | metabol | 3_57269656_A_G |
| 41 | ETS1_5 | 1054_Palbociclib_2 | cell_cyc | 5_139680901_G_A / 5_150375777_G_T / 5_150393369_C_T / 9_41040359_C_T / 9_41938485_A_G |
| 42 | MDM2_4 | 1047_Nutlin-3a (-)_2 | p53 | 8_89769704_A_C / 8_89786745_A_T / 8_89786749_T_TC / 8_89790263_A_G |
| 43 | NECAP1_1 | 1264_SGC0946_3 | chromatin | 11_92883335_A_C |
| 44 | PDZD8_1 | 194_Luminespib_2 | other | 2_120289468_AT_A |
| 45 | IFT46_1 | 1149_TW_37_3 | apop | 16_88608786_A_G |
| 46 | PLEKHA1_1 | 1032_Afatinib_1 | egfr | 16_89546571_ACC_AC |
| 47 | PTPN12_1 | 1006_Cytarabine_1 | DNArep | 7_63297679_T_C |
| 48 | CRH_1 | 277_Linifanib_2 | rtk | 2_208165676_C_T |
| 49 | UBE3B_1 | 301_PHA-793887_3 | cell_cyc | 1_3729650_T_C |
| No. | FRH | Var_Exp(pval) | Var_Drug(pval) | Exp_Drug(pval) | Ave_VarDrug(pval) | Rank |
| 1 | IRX5_3 | 3.24E-08 | 2.09E-07 / 3.36E-07 / 1.23E-06 / 3.42E-06 / 5.09E-06 / 1.67E-05 / 7.91E-05 / 9.90E-05 / 0.000147359 / 0.000178145 / 0.000262223 / 0.000293231 / 0.000294131 / 0.000331406 / 0.000346165 / 0.000948858 / 0.002531744 / 0.002544254 / 0.002864291 / 0.003760149 / 0.004676935 / 0.004858024 / 0.005464656 / 0.005509754 / 0.005666416 / 0.005771071 / 0.006260361 / 0.006581211 / 0.006918188 / 0.007120129 / 0.00796253 / 0.008656866 / 0.009456152 / 0.009577377 / 0.009788614 | 4.01E-09 / 2.44E-07 / 2.68E-10 / 4.32E-09 / 3.38E-07 / 2.17E-07 / 0.00038571 / 0.000925853 / 7.73E-07 / 0.000383325 / 0.166450357 / 4.98E-06 / 3.01E-07 / 0.002000118 / 0.000442004 / 5.99E-05 / 0.000267605 / 0.213034545 / 0.159498838 / 0.00525218 / 0.00102741 / 0.020521632 / 0.009232963 / 0.002752168 / 0.238349359 / 0.011791795 / 0.003679783 / 0.012982528 / 0.023648082 / 0.203584523 / 4.71E-06 / 0.03105291 / 0.009132949 / 0.044459166 / 0.000738179 | 3.40E-03 | 35 |
| 2 | IRX5_1 | 0.0000015986 | 0.0007150123535033939 / 0.0003369412837112573 / 0.00032406884840248645 / 0.03648245720851939 / 0.0011099296303187667 / 0.006369243766371333 / 0.0005814803877258011 / 2.2678944506803809e-07 / 0.03733962059148955 | 4.012472503651177e-09 / 2.6827328582081137e-10 / 4.315496540370196e-09 / 3.0113839929611485e-07 / 2.1676383298007365e-07 / 7.7324514359278e-07 / 3.3835336443110047e-07 / 2.4825768930569727e-07 / 4.858619088818164e-06 | 0.009251 | 9 |
| 3 | CMIP_1 | 0.0000003363 | 0.00011611305549562358 / 0.0012463700637828415 / 0.0030883823789405102 / 0.0016967292437561562 / 0.009832494532448445 / 0.002480457099824004 | 1.6131899966597346e-09 / 6.919962939545994e-07 / 2.849790178430554e-07 / 2.9927531009991034e-06 / 1.2590036500767103e-06 / 2.2920451294642218e-05 | 0.003077 | 6 |
| 4 | PREX1_1 | 0.0000031534 | 0.01213588709116456 / 0.0008861989870959789 / 0.003387644664627276 / 0.005046821727923961 / 0.003659189631662927 / 0.0025267752687901323 | 2.0425679890502906e-07 / 7.604358543728916e-08 / 1.5529027829933754e-06 / 8.474366468515741e-07 / 4.250842448563364e-06 / 0.00011933684147066083 | 0.004607 | 6 |
| 5 | HIST1H2BK_1 | 0.0000012706 | 2.0249380516365964e-05 / 0.00145858467735631 / 0.00010968434987171273 | 1.2231056098636564e-07 / 5.613023240161599e-07 / 1.606715671371094e-06 | 0.00053 | 3 |
| 6 | SERPINE1_2 | 0.0000002953 | 0.0003204627533032064 / 0.00024487596208109635 / 0.0018306053201144902 | 2.270680653678334e-11 / 2.0037545467736346e-09 / 1.775004443361545e-08 | 0.000799 | 3 |
| 7 | SGTB_1 | 0.0000081282 | 0.03228197565235906 / 0.005309250379800075 / 0.014353588850730884 | 7.002520053010446e-07 / 5.734586888069177e-07 / 3.864698922480986e-05 | 0.017315 | 3 |
| 8 | XYLT2_1 | 0.0000020721 | 0.001833777815813712 / 0.0011629202987970622 | 0.000260290223137108 / 2.671958043521113e-05 | 0.001498 | 2 |
| 9 | SOGA2_1 | 0.0000002061 | 0.0023870087560347447 / 0.0009469777545024177 | 4.478657034092263e-06 / 1.4354947060633677e-06 | 0.001667 | 2 |
| 10 | ZC3H12C_1 | 0.0000026717 | 0.00215309882934333 / 0.017221760779553733 | 4.767376309274578e-08 / 6.661607188017109e-09 | 0.009687 | 2 |
| 11 | AFAP1L2_1 | 0.0000003807 | 0.004214389226040113 / 0.02332396009307528 | 5.907987029847344e-06 / 2.4672683509692957e-05 | 0.013769 | 2 |
| 12 | CHRNA5_1 | 0.0000508839 | 0.006701963959523267 / 0.036047880162305805 | 1.9077675767419626e-05 / 0.0006068009313248781 | 0.021375 | 2 |
| 13 | ASGR2_1 | 0.0000011382 | 0.02920277002386234 / 0.016061730805368494 | 3.539163247328943e-06 / 6.152399665513134e-06 | 0.022632 | 2 |
| 14 | RHBDL2_5 | 0.0000019238 | 7.1199917547458675e-06 | 0.0003696677024808176 | 7.12E-06 | 1 |
| 15 | TMEM206_3 | 0.0000000202 | 0.00010519155045059184 | 5.5593739090589024e-05 | 0.000105 | 1 |
| 16 | SUPT4H1_1 | 0.0000006972 | 0.00033848343004505154 | 6.5359378871259295e-06 | 0.000338 | 1 |
| 17 | LRTOMT_1 | 0.0000018098 | 0.000559295705994161 | 1.3683390744827602e-05 | 0.000559 | 1 |
| 18 | EME2_1 | 0.0000170380 | 0.0006898652477534458 | 2.7131355664636215e-07 | 0.00069 | 1 |
| 19 | TMEM158_1 | 0.0000030678 | 0.0009840625910486822 | 1.609343995544786e-08 | 0.000984 | 1 |
| 20 | EFS_1 | 0.0002217830 | 0.001122491007265465 | 1.5915921114557537e-06 | 0.001122 | 1 |
| 21 | CA5B_1 | 0.0000190483 | 0.0014397265221401374 | 8.834878342812196e-06 | 0.00144 | 1 |
| 22 | SDC1_1 | 0.0000871778 | 0.0021240823853264194 | 0.000582674749763457 | 0.002124 | 1 |
| 23 | QSER1_1 | 0.0036525535 | 0.0037407673565606763 | 0.006866210754238516 | 0.003741 | 1 |
| 24 | GALNTL5_2 | 0.0000004536 | 0.0038242994255904676 | 3.729288833430345e-05 | 0.003824 | 1 |
| 25 | JAG1_5 | 0.0001089795 | 0.00636641270645681 | 1.7383815237379935e-05 | 0.006366 | 1 |
| 26 | SOAT1_1 | 0.0000020782 | 0.006999312347871926 | 2.80467015954591e-08 | 0.006999 | 1 |
| 27 | BIRC2_1 | 0.0000155207 | 0.00816300663512002 | 0.00018077138183493182 | 0.008163 | 1 |
| 28 | NAALADL2_1 | 0.0000138905 | 0.008284426750211397 | 4.480439955191913e-07 | 0.008284 | 1 |
| 29 | RGS2_1 | 0.0000013280 | 0.009860060162808696 | 1.7551881489443127e-06 | 0.00986 | 1 |
| 30 | PRR12_1 | 0.0000069754 | 0.009867491010242535 | 1.7189797251912035e-05 | 0.009867 | 1 |
| 31 | AXL_2 | 0.0000000105 | 0.014240994766530759 | 1.5079800937023606e-08 | 0.014241 | 1 |
| 32 | C6orf203_3 | 0.0000002251 | 0.01855978051000038 | 0.008786487798916599 | 0.01856 | 1 |
| 33 | RNF208_2 | 0.0000001032 | 0.030124190690403667 | 0.009683329859510285 | 0.030124 | 1 |
| 34 | TNFRSF21_1 | 0.0000749035 | 0.03240280858096773 | 0.00031416021519650137 | 0.032403 | 1 |
| 35 | MAP6_1 | 0.0000692014 | 0.03353292578624218 | 0.00013432237477471032 | 0.033533 | 1 |
| 36 | ABLIM1_1 | 0.0000289457 | 8.551014437375636e-05 / 6.439870760609185e-05 / 0.0004942044619000223 / 0.0013462707233938519 / 0.0001769380795123695 / 0.00046864428768627844 | 6.495937674540172e-07 / 8.724045720306562e-07 / 4.458187235187017e-06 / 0.00014338311206655668 / 8.320751548561286e-05 / 8.117521266562836e-06 | 0.000439 | 6 |
| 37 | DIAPH1_5 | 0.0000000343 | 0.0021569775481875115 / 0.009558471051782936 | 4.2351723063700285e-07 / 0.0007897012263719693 | 0.005858 | 2 |
| 38 | FBXO10_5 | 0.0000511525 | 0.012717520661373393 / 0.011413820480670385 | 3.075936790924862e-05 / 5.483582287867406e-06 | 0.012066 | 2 |
| 39 | OLR1_1 | 0.0000390604 | 0.00013538297001416112 | 0.0010150743709979484 | 0.000135 | 1 |
| 40 | ADK_1 | 0.0000356335 | 0.0003915086428142265 | 8.510841943631868e-06 | 0.000392 | 1 |
| 41 | ETS1_5 | 0.0000663161 | 0.00041860694731410804 | 7.897108946289616e-05 | 0.000419 | 1 |
| 42 | MDM2_4 | 0.0000777136 | 0.00045220053022167466 | 1.1021957487827008e-06 | 0.000452 | 1 |
| 43 | NECAP1_1 | 0.0000018931 | 0.006023068066858825 | 1.373445231848715e-05 | 0.006023 | 1 |
| 44 | PDZD8_1 | 0.0000027222 | 0.011837688751336296 | 0.0006499029052944853 | 0.011838 | 1 |
| 45 | IFT46_1 | 0.0000115713 | 0.016014639151541662 | 0.004518015024378813 | 0.016015 | 1 |
| 46 | PLEKHA1_1 | 0.0011885939 | 0.01781962701682115 | 1.7283045033609196e-07 | 0.01782 | 1 |
| 47 | PTPN12_1 | 0.0001114367 | 0.02274194948059581 | 1.024090488420046e-06 | 0.022742 | 1 |
| 48 | CRH_1 | 0.0000029508 | 0.03250849770203413 | 0.0017907240115171536 | 0.032508 | 1 |
| 49 | UBE3B_1 | 0.0000100508 | 0.048482309371415636 | 1.9954445445928623e-06 | 0.048482 | 1 |
[표 6]에는 뇌종양(brain) 약물에 연관된 FRH 들과, 이와 연관된 뇌종양 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 7] 에는 [표 6]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(Pvlaue)값을 의미하는 것으로, [표 6]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 6]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 뇌종양 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 29에는 표 6에 기재된 바이오마커들 중 주요 바이오마커들의 뇌종양 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 30에는 주요 바이오마커들에 의해 발현된 유전자들과 뇌종양 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Drug | DrugType | Var(마커) |
| 1 | PTRF_9 | 9_MG-132 / 17_Cyclopamine / 34_Imatinib / 51_Dasatinib / 56_WH-4-023 / 94_TGX221 / 104_Bortezomib / 106_XMD8-85 / 147_NSC-87877 / 150_Bicalutamide / 151_QS11 / 156_AZD6482 / 159_HG-6-64-1 / 175_PAC-1 / 176_IPA-3 / 178_BAY 61-3606 / 179_5-Fluorouracil / 184_BMS-754807 / 185_OSI-906 / 186_Bexarotene / 196_Phenformin / 199_Pazopanib / 200_LAQ824 / 211_TL-2-105 / 221_TAK-715 / 226_GSK1070916 / 228_KIN001-102 / 253_XMD14-99 / 254_AC220 / 255_CP724714 / 257_NPK76-II-72-1 / 263_FR-180204 / 265_Tubastatin A / 269_NSC-207895 / 272_AR-42 / 275_I-BET-762 / 276_CAY10603 / 281_CH5424802 / 288_KIN001-055 / 290_KIN001-260 / 291_KIN001-266 / 293_MP470 / 294_MPS-1-IN-1 / 300_CX-5461 / 304_SB52334 / 305_TPCA-1 / 310_YM201636 / 333_T0901317 / 344_THZ-2-49 / 345_KIN001-270 / 1007_Docetaxel / 1008_Methotrexate / 1011_ABT-263 / 1012_Vorinostat / 1016_Temsirolimus / 1020_Lenalidomide / 1021_Axitinib / 1026_17-AAG / 1043_JNK Inhibitor VIII / 1091_BMS-536924 / 1166_QL-VIII-58 / 1248_FK866 / 1261_rTRAIL / 1262_UNC1215 / 1264_SGC0946 / 1526_RDEA119 (rescreen) / 1527_GDC0941 (rescreen) | other / other / abl / abl / abl / pi3k / other / other / other / other / other / pi3k / erk_mapk / apop / cytoskeleton / other / DNArep / igfr / igfr / other / metabol / rtk / chromatin / erk_mapk / jnk_p38 / mitosis / pi3k / rtk / rtk / egfr / mitosis / erk_mapk / chromatin / p53 / chromatin / chromatin / chromatin / rtk / other / other / other / rtk / mitosis / other / rtk / other / other / other / cell_cyc / cell_cyc / cytoskeleton / DNArep / apop / chromatin / tor / other / rtk / other / jnk_p38 / igfr / tor / metabol / apop / other / chromatin / erk_mapk / pi3k | 11_12162199_T_G / 13_113159942_A_G / 5_181155466_T_G / 11_65547388_T_G / 10_11921140_T_G / 17_55774876_T_G / 12_40313960_G_T / 16_1817242_T_C / 2_113934259_C_T |
| 2 | MBTD1_5 | 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 226_GSK1070916_2 / 179_5-Fluorouracil_1 / 221_TAK-715_2 / 257_NPK76-II-72-1_3 / 275_I-BET-762_3 / 276_CAY10603_3 / 1011_Navitoclax_2 / 269_NSC-207895_3 / 281_Alectinib_2 / 300_CX-5461_3 / 265_Tubastatin A_3 / 185_Linsitinib_2 / 253_XMD14-99_3 | other / mitosis / rtk / chromatin / mitosis / DNArep / jnk_p38 / mitosis / chromatin / chromatin / apop / p53 / rtk / other / chromatin / igfr / rtk | 17_55774876_T_G / 15_65451964_A_G / 2_113934259_C_T / 12_57062993_T_G / 11_65547388_T_G |
| 3 | C12orf29_4 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 275_I-BET-762_3 / 272_AR-42_2 / 310_YM201636_3 / 1012_Vorinostat_1 / 276_CAY10603_3 / 184_BMS-754807_2 | mitosis / igfr / erk_mapk / other / chromatin / chromatin / other / chromatin / chromatin / igfr | 12_40313960_G_T / 4_173528913_A_G / 15_65451964_A_G / 10_79312556_A_G |
| 4 | DDX20_1 | 294_MPS-1-IN-1_3 / 265_Tubastatin A_3 / 305_TPCA-1_3 / 300_CX-5461_3 / 257_NPK76-II-72-1_3 / 179_5-Fluorouracil_1 / 290_KIN001-260_3 / 276_CAY10603_3 / 1012_Vorinostat_1 / 345_KIN001-270_3 | mitosis / chromatin / other / other / mitosis / DNArep / other / chromatin / chromatin / cell_cyc | 8_30756677_T_G |
| 5 | TACC1_4 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 221_TAK-715_2 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 253_XMD14-99_3 / 300_CX-5461_3 | chromatin / mitosis / rtk / jnk_p38 / DNArep / other / rtk / erk_mapk / rtk / other | 11_12162199_T_G / 12_51745916_T_G / 16_15664675_G_T / 16_55415_T_G |
| 6 | SFPQ_1 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 179_5-Fluorouracil_1 / 309_Y-39983_3 / 265_Tubastatin A_3 / 275_I-BET-762_3 / 263_FR-180204_3 | chromatin / other / mitosis / other / other / DNArep / cytoskeleton / chromatin / chromatin / erk_mapk | 8_30756677_T_G |
| 7 | LRPPRC_2 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 1091_BMS-536924_3 / 253_XMD14-99_3 / 293_Amuvatinib_2 / 184_BMS-754807_2 / 257_NPK76-II-72-1_3 | mitosis / other / rtk / igfr / chromatin / igfr / rtk / rtk / igfr / mitosis | 12_40313960_G_T / 11_12162199_T_G |
| 8 | ILF3_5 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 1011_Navitoclax_2 / 263_FR-180204_3 / 288_WHI-P97_3 / 257_NPK76-II-72-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 | mitosis / other / chromatin / apop / erk_mapk / other / mitosis / DNArep / rtk | 5_181155466_T_G / 2_113934259_C_T / 11_12162199_T_G / 12_6818898_A_C / 15_65451964_A_G |
| 9 | ATXN7L3B_5 | 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 / 185_Linsitinib_2 / 226_GSK1070916_2 / 184_BMS-754807_2 | other / mitosis / chromatin / rtk / mitosis / p53 / igfr / mitosis / igfr | 2_113934259_C_T / 5_181155466_T_G / 15_65451964_A_G / 2_108507561_T_G / 12_57062993_T_G |
| 10 | CENPV_1 | 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 300_CX-5461_3 / 305_TPCA-1_3 / 304_SB52334_3 / 1011_Navitoclax_2 / 185_Linsitinib_2 | DNArep / chromatin / rtk / mitosis / other / other / rtk / apop / igfr | 5_181155466_T_G |
| 11 | CAMKV_4 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 253_XMD14-99_3 | mitosis / DNArep / other / other / rtk / chromatin / erk_mapk / rtk | 13_113159942_A_G / 16_1817242_T_C / 3_128945112_G_A / 20_42084724_T_C |
| 12 | TPMT_3 | 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 226_GSK1070916_2 | rtk / mitosis / chromatin / rtk / DNArep / igfr / igfr / mitosis | 9_37887606_C_T / 2_61492168_C_A / 11_12162199_T_G |
| 13 | WASF1_3 | 305_TPCA-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 / 269_NSC-207895_3 / 185_Linsitinib_2 | other / chromatin / DNArep / mitosis / rtk / other / p53 / igfr | 16_55415_T_G / 10_43200831_A_G / 2_108507561_T_G |
| 14 | DDX25_4 | 263_FR-180204_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 255_CP724714_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 | erk_mapk / chromatin / mitosis / other / rtk / egfr / other / DNArep | 2_61492168_C_A / 5_181155466_T_G / 11_43920052_A_C / 12_40313960_G_T |
| 15 | ACVR2B_5 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 265_Tubastatin A_3 / 1011_Navitoclax_2 / 263_FR-180204_3 | DNArep / mitosis / rtk / chromatin / other / chromatin / apop / erk_mapk | 16_1817242_T_C / 10_11921140_T_G / 13_113159942_A_G / 20_42084724_T_C / 11_34452090_T_G |
| 16 | TAP1_4 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 1011_Navitoclax_2 / 304_SB52334_3 / 305_TPCA-1_3 / 275_I-BET-762_3 | mitosis / DNArep / chromatin / igfr / apop / rtk / other / chromatin | 11_12162199_T_G / 10_11921140_T_G / 5_181155466_T_G / 20_42084724_T_C |
| 17 | SMPD1_1 | 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 1011_Navitoclax_2 / 265_Tubastatin A_3 | chromatin / DNArep / other / other / mitosis / jnk_p38 / apop / chromatin | 16_87644643_G_A |
| 18 | PEA15_5 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 293_Amuvatinib_2 / 226_GSK1070916_2 / 305_TPCA-1_3 / 221_TAK-715_2 / 263_FR-180204_3 | chromatin / mitosis / rtk / rtk / mitosis / other / jnk_p38 / erk_mapk | 5_181155466_T_G / 10_50311228_T_G / 11_12162199_T_G / 22_18345007_A_C / 2_60761746_T_G |
| 19 | SLC25A43_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 253_XMD14-99_3 / 179_5-Fluorouracil_1 | mitosis / other / rtk / igfr / chromatin / erk_mapk / rtk / DNArep | 1_54243266_A_G |
| 20 | MT2A_5 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 275_I-BET-762_3 / 304_SB52334_3 / 185_Linsitinib_2 | mitosis / DNArep / other / mitosis / chromatin / rtk / igfr | 13_113159942_A_G / 22_42212334_A_C / 10_11921140_T_G / 15_75524142_T_C / X_100585180_G_T |
| 21 | RUNX1_2 | 196_Phenformin_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 94_TGX221_3 / 1166_QL-VIII-58_3 / 51_Dasatinib_1 / 1007_Docetaxel_1 | metabol / cell_cyc / pi3k / pi3k / tor / abl / cytoskeleton | 1_78629896_T_C / 8_7290003_A_C |
| 22 | LRRC8B_3 | 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 263_FR-180204_3 / 276_CAY10603_3 | mitosis / rtk / other / DNArep / other / erk_mapk / chromatin | 12_40313960_G_T / 11_12162199_T_G / 17_55774876_T_G |
| 23 | PSMB9_4 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 275_I-BET-762_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 | mitosis / rtk / DNArep / chromatin / other / chromatin / igfr | 11_12162199_T_G / 10_11921140_T_G / 16_55415_T_G / X_2856636_A_C |
| 24 | RRAS_5 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 269_NSC-207895_3 / 304_SB52334_3 | mitosis / DNArep / other / apop / other / p53 / rtk | 11_12162199_T_G / 2_113934259_C_T / 16_18379704_T_G / 13_113159942_A_G / 17_55774876_T_G |
| 25 | TMBIM1_5 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 185_Linsitinib_2 | mitosis / DNArep / rtk / other / chromatin / other / igfr | 17_51169925_C_T / 1_228244520_T_G / 1_213007133_T_G / 16_55415_T_G / 5_38950065_A_T |
| 26 | KLHL23_3 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 263_FR-180204_3 / 1011_Navitoclax_2 / 300_CX-5461_3 / 1012_Vorinostat_1 | mitosis / DNArep / rtk / erk_mapk / apop / other / chromatin | 13_113159942_A_G / 10_79312556_A_G / 13_113325635_A_G |
| 27 | EWSR1_1 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 288_WHI-P97_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 310_YM201636_3 | mitosis / apop / other / other / DNArep / chromatin / other | 20_42084724_T_C |
| 28 | ZNF124_3 | 1012_Vorinostat_1 / 1011_Navitoclax_2 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 | chromatin / apop / rtk / mitosis / other / other / DNArep | 13_113159942_A_G / 2_170965958_A_C / 17_55774876_T_G |
| 29 | CAPG_2 | 1026_Tanespimycin_2 / 344_THZ-2-49_3 / 196_Phenformin_3 / 1527_Pictilisib_2 / 17_Cyclopamine_3 / 94_TGX221_3 / 1007_Docetaxel_1 | other / cell_cyc / metabol / pi3k / other / pi3k / cytoskeleton | 7_72942379_A_C / 15_56464990_A_C |
| 30 | TGOLN2_2 | 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 304_SB52334_3 / 300_CX-5461_3 | chromatin / DNArep / mitosis / other / erk_mapk / rtk / other | 19_7740447_T_G / 19_11402175_A_C |
| 31 | RBFOX1_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2 / 305_TPCA-1_3 / 253_XMD14-99_3 | mitosis / rtk / other / DNArep / rtk / other / rtk | 1_213007133_T_G |
| 32 | RANBP2_2 | 305_TPCA-1_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 269_NSC-207895_3 / 257_NPK76-II-72-1_3 | other / rtk / mitosis / DNArep / other / p53 / mitosis | 11_65547388_T_G / 15_55329691_T_C |
| 33 | CCT2_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 269_NSC-207895_3 / 272_AR-42_2 / 185_Linsitinib_2 | mitosis / other / chromatin / erk_mapk / p53 / chromatin / igfr | 12_40313960_G_T |
| 34 | CEP95_2 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 304_SB52334_3 / 253_XMD14-99_3 / 281_Alectinib_2 / 1012_Vorinostat_1 | DNArep / mitosis / mitosis / rtk / rtk / rtk / chromatin | 17_55774876_T_G / 11_12162199_T_G |
| 35 | GINM1_3 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 184_BMS-754807_2 / 1091_BMS-536924_3 | mitosis / erk_mapk / rtk / igfr / chromatin / igfr / igfr | 11_12162199_T_G / 4_154328181_A_C / 10_73803641_A_G |
| 36 | POLG2_2 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 304_SB52334_3 / 1091_BMS-536924_3 / 281_Alectinib_2 / 253_XMD14-99_3 | chromatin / mitosis / jnk_p38 / rtk / igfr / rtk / rtk | 22_22098988_G_T / 19_4911043_A_C |
| 37 | RAN_2 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2 | mitosis / apop / chromatin / erk_mapk / other / DNArep / rtk | 19_3281403_A_C / 10_11921140_T_G |
| 38 | MTF2_2 | 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 265_Tubastatin A_3 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 / 304_SB52334_3 | other / mitosis / DNArep / chromatin / mitosis / p53 / rtk | 5_181155466_T_G / 6_30705792_T_G |
| 39 | CMPK1_1 | 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 184_BMS-754807_2 / 1012_Vorinostat_1 / 293_Amuvatinib_2 / 253_XMD14-99_3 / 304_SB52334_3 | igfr / mitosis / igfr / chromatin / rtk / rtk / rtk | 16_18379704_T_G |
| 40 | MDN1_1 | 1012_Vorinostat_1 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 276_CAY10603_3 / 305_TPCA-1_3 / 269_NSC-207895_3 | chromatin / apop / DNArep / mitosis / chromatin / other / p53 | 11_65547388_T_G |
| 41 | INPP1_2 | 265_Tubastatin A_3 / 276_CAY10603_3 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 310_YM201636_3 | chromatin / chromatin / other / mitosis / DNArep / other | 14_78966462_C_T / 16_55415_T_G |
| 42 | TOMM20_5 | 1012_Vorinostat_1 / 253_XMD14-99_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 300_CX-5461_3 | chromatin / rtk / DNArep / mitosis / rtk / other | 10_11921140_T_G / 20_42084724_T_C / 2_61492168_C_A / 17_55774876_T_G / 16_18379704_T_G |
| 43 | S100A6_3 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 305_TPCA-1_3 | chromatin / mitosis / rtk / DNArep / apop / other | 10_11921140_T_G / 7_159142364_T_G / 8_30756677_T_G |
| 44 | ZNF74_5 | 1012_Vorinostat_1 / 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 305_TPCA-1_3 / 304_SB52334_3 | chromatin / igfr / mitosis / igfr / other / rtk | 5_181155466_T_G / 17_55774876_T_G / 1_234373536_T_G / 2_113934259_C_T / 2_61492168_C_A |
| 45 | ZNF195_3 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 185_Linsitinib_2 / 226_GSK1070916_2 | mitosis / other / rtk / erk_mapk / igfr / mitosis | 12_40313960_G_T / 2_113934259_C_T / 12_51745916_T_G |
| 46 | DNMT3A_2 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 263_FR-180204_3 / 1091_BMS-536924_3 | mitosis / other / chromatin / igfr / erk_mapk / igfr | 2_113934259_C_T / 11_12162199_T_G |
| 47 | PXDC1_3 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 | mitosis / rtk / other / igfr / DNArep / chromatin | 13_113159942_A_G / 11_65547388_T_G / 7_159142364_T_G |
| 48 | HOXD8_1 | 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 185_Linsitinib_2 / 281_Alectinib_2 | rtk / mitosis / rtk / erk_mapk / igfr / rtk | 20_42084724_T_C |
| 49 | CREB3_5 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 253_XMD14-99_3 / 304_SB52334_3 | mitosis / chromatin / other / DNArep / rtk / rtk | 5_181155466_T_G / 1_54243266_A_G / 11_12162199_T_G / 6_30705792_T_G / 12_6818898_A_C |
| 50 | HDAC2_5 | 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 293_Amuvatinib_2 / 1012_Vorinostat_1 / 304_SB52334_3 | apop / DNArep / other / rtk / chromatin / rtk | 17_55774876_T_G / 11_65547388_T_G / 15_75524142_T_C / 14_55169342_TAAA_T / 15_55329691_T_C |
| 51 | TIMP1_5 | 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 253_XMD14-99_3 | DNArep / other / other / mitosis / apop / rtk | 16_1817242_T_C / 3_128945112_G_A / 5_181155466_T_G / 16_30398066_C_A / 11_34452090_T_G |
| 52 | COQ10B_2 | 305_TPCA-1_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 | other / chromatin / mitosis / rtk / igfr / DNArep | 13_113159942_A_G / 1_149852603_A_G |
| 53 | REEP5_3 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 257_NPK76-II-72-1_3 / 304_SB52334_3 | mitosis / other / DNArep / other / mitosis / rtk | 5_181155466_T_G / 16_87644643_G_A / 2_113934259_C_T |
| 54 | FAM111A_5 | 304_SB52334_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 1091_BMS-536924_3 | rtk / mitosis / igfr / chromatin / other / igfr | 2_108507561_T_G / 13_113159942_A_G / 10_11921140_T_G / 16_1817242_T_C / 1_213007133_T_G |
| 55 | XPO5_2 | 1012_Vorinostat_1 / 269_NSC-207895_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 276_CAY10603_3 / 294_MPS-1-IN-1_3 | chromatin / p53 / other / mitosis / chromatin / mitosis | 15_75524142_T_C / 11_65547388_T_G |
| 56 | MICALL2_2 | 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 / 156_AZD6482_2 | cell_cyc / metabol / pi3k / other / abl / pi3k | 8_7290003_A_C / 7_72942379_A_C |
| 57 | ITGA3_1 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 288_WHI-P97_3 | mitosis / chromatin / erk_mapk / other / DNArep / other | 5_181155466_T_G |
| 58 | MATR3_5 | 304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 269_NSC-207895_3 / 1011_Navitoclax_2 | rtk / other / mitosis / DNArep / p53 / apop | 17_55774876_T_G / 10_73803531_T_C / 11_65547388_T_G / 12_7433515_G_T / 16_18379704_T_G |
| 59 | SAT1_1 | 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 305_TPCA-1_3 / 185_Linsitinib_2 | mitosis / rtk / chromatin / erk_mapk / other / igfr | 12_40313960_G_T |
| 60 | TMED9_2 | 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 263_FR-180204_3 | other / mitosis / rtk / igfr / chromatin / erk_mapk | 13_113159942_A_G / 11_12162199_T_G |
| 61 | KIF26A_2 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 1091_BMS-536924_3 / 263_FR-180204_3 / 185_Linsitinib_2 | chromatin / mitosis / rtk / igfr / erk_mapk / igfr | 10_11921140_T_G / 7_159142364_T_G |
| 62 | C19orf66_2 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 253_XMD14-99_3 / 293_Amuvatinib_2 / 310_YM201636_3 | mitosis / rtk / other / rtk / rtk / other | 16_87644643_G_A / X_2856636_A_C |
| 63 | GTF3C2_2 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 263_FR-180204_3 / 281_Alectinib_2 / 185_Linsitinib_2 | mitosis / chromatin / rtk / erk_mapk / rtk / igfr | 7_128839939_T_G / 7_159142364_T_G |
| 64 | ADAM9_5 | 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 185_Linsitinib_2 / 1011_Navitoclax_2 | mitosis / rtk / DNArep / rtk / igfr / apop | 11_12162199_T_G / 12_51745916_T_G / 10_11921140_T_G / 8_122952205_T_G / 5_181155466_T_G |
| 65 | KDM1A_3 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 176_IPA-3_3 / 179_5-Fluorouracil_1 / 276_CAY10603_3 | mitosis / chromatin / other / cytoskeleton / DNArep / chromatin | 1_26774532_T_C / 22_42212334_A_C / 5_181155466_T_G |
| 66 | SRSF1_1 | 1012_Vorinostat_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 179_5-Fluorouracil_1 / 281_Alectinib_2 | chromatin / rtk / mitosis / mitosis / DNArep / rtk | 16_87644643_G_A |
| 67 | WHAMM_1 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 281_Alectinib_2 / 263_FR-180204_3 / 300_CX-5461_3 / 253_XMD14-99_3 | chromatin / other / rtk / erk_mapk / other / rtk | 2_113934259_C_T |
| 68 | LEPRE1_4 | 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 106_XMD8-85_3 / 156_AZD6482_2 | cell_cyc / pi3k / other / metabol / other / pi3k | 3_191357867_G_A / 16_72119226_C_G / 3_191358113_C_T / 16_72150667_C_T |
| 69 | TRMT61B_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 265_Tubastatin A_3 / 276_CAY10603_3 / 185_Linsitinib_2 | mitosis / other / rtk / chromatin / chromatin / igfr | 12_124473081_C_T |
| 70 | KANK1_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 305_TPCA-1_3 / 253_XMD14-99_3 | mitosis / rtk / igfr / igfr / other / rtk | 11_12162199_T_G |
| 71 | FAM126A_1 | 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 156_AZD6482_2 / 51_Dasatinib_1 / 196_Phenformin_3 | pi3k / cell_cyc / other / pi3k / abl / metabol | 7_72942379_A_C |
| 72 | CASKIN1_1 | 1012_Vorinostat_1 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 | chromatin / apop / DNArep / mitosis / rtk / igfr | 10_11921140_T_G |
| 73 | PHIP_3 | 269_NSC-207895_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 257_NPK76-II-72-1_3 / 300_CX-5461_3 | p53 / mitosis / other / DNArep / mitosis / other | 15_55329691_T_C / 15_55340661_G_T / 12_40313960_G_T |
| 74 | ISL1_1 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 / 1011_Navitoclax_2 / 281_Alectinib_2 / 304_SB52334_3 | mitosis / chromatin / erk_mapk / apop / rtk / rtk | 11_12162199_T_G |
| 75 | FAM114A1_1 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 275_I-BET-762_3 / 300_CX-5461_3 | mitosis / DNArep / chromatin / other / chromatin / other | 12_51745916_T_G |
| 76 | BHLHE40_5 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 1091_BMS-536924_3 | chromatin / mitosis / erk_mapk / rtk / other / igfr | 11_12162199_T_G / 6_30705792_T_G / 8_122952205_T_G / 14_93183653_A_C / 12_6941768_C_A |
| 77 | RNH1_2 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 269_NSC-207895_3 / 281_Alectinib_2 / 253_XMD14-99_3 | mitosis / DNArep / other / p53 / rtk / rtk | 16_1817242_T_C / 13_113159942_A_G |
| 78 | SLC35F5_2 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 1012_Vorinostat_1 / 300_CX-5461_3 | mitosis / other / DNArep / rtk / chromatin / other | 17_6118065_A_G / 13_113159942_A_G |
| 79 | TRAP1_1 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 263_FR-180204_3 / 1011_Navitoclax_2 | chromatin / mitosis / other / rtk / erk_mapk / apop | 9_69516199_A_C |
| 80 | SLC10A3_1 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 304_SB52334_3 | DNArep / mitosis / chromatin / other / other / rtk | 13_113159942_A_G |
| 81 | IL10RB_1 | 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 184_BMS-754807_2 / 263_FR-180204_3 | igfr / mitosis / apop / other / igfr / erk_mapk | 11_65547388_T_G |
| 82 | CCDC138_3 | 269_NSC-207895_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 257_NPK76-II-72-1_3 | p53 / chromatin / other / DNArep / mitosis | 15_75524142_T_C / 12_40313960_G_T / 8_30756677_T_G |
| 83 | LDLRAP1_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 304_SB52334_3 / 179_5-Fluorouracil_1 | mitosis / other / igfr / rtk / DNArep | 16_55415_T_G |
| 84 | SH3BGRL3_3 | 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 304_SB52334_3 / 253_XMD14-99_3 | DNArep / other / apop / rtk / rtk | 17_55774876_T_G / 16_87644643_G_A / 5_181155466_T_G |
| 85 | RARRES3_3 | 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 179_5-Fluorouracil_1 / 263_FR-180204_3 / 1012_Vorinostat_1 | mitosis / chromatin / DNArep / erk_mapk / chromatin | 12_40313960_G_T / 1_213007133_T_G / 16_87644643_G_A |
| 86 | ANXA4_4 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 293_Amuvatinib_2 | mitosis / chromatin / rtk / DNArep / rtk | 19_11402175_A_C / 6_33799054_A_G / 8_30756677_T_G / 8_27431326_A_G |
| 87 | LYST_1 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 / 310_YM201636_3 | chromatin / other / mitosis / rtk / other | 16_55415_T_G |
| 88 | MR1_4 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 1012_Vorinostat_1 | mitosis / apop / DNArep / other / chromatin | 1_234373536_T_G / 15_84241166_A_C / 10_79312556_A_G / 19_7740447_T_G |
| 89 | SELRC1_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 226_GSK1070916_2 / 253_XMD14-99_3 | mitosis / other / chromatin / mitosis / rtk | 12_40313960_G_T |
| 90 | LDHB_5 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 | chromatin / other / mitosis / DNArep / apop | 12_40313960_G_T / 11_12162199_T_G / 11_65547388_T_G / 5_181155466_T_G / 4_108762737_T_G |
| 91 | GBE1_2 | 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 51_Dasatinib_1 | cell_cyc / pi3k / other / metabol / abl | 8_7290003_A_C / 7_72942379_A_C |
| 92 | PTRF_2 | 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 | cell_cyc / pi3k / metabol / other / abl | 8_7290003_A_C / 7_72942379_A_C |
| 93 | SQSTM1_3 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 304_SB52334_3 / 179_5-Fluorouracil_1 | mitosis / other / igfr / rtk / DNArep | 1_26774532_T_C / 11_12162199_T_G / 13_39724512_C_T |
| 94 | PA2G4_1 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 1011_Navitoclax_2 / 310_YM201636_3 | chromatin / mitosis / other / apop / other | 12_40313960_G_T |
| 95 | GBP3_2 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 1091_BMS-536924_3 / 305_TPCA-1_3 / 253_XMD14-99_3 | mitosis / chromatin / igfr / other / rtk | 15_75524142_T_C / 12_40313960_G_T |
| 96 | CHD7_2 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 / 275_I-BET-762_3 | DNArep / mitosis / chromatin / other / chromatin | 11_65547388_T_G / 12_40313960_G_T |
| 97 | ELF4_4 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1091_BMS-536924_3 / 304_SB52334_3 / 263_FR-180204_3 | mitosis / igfr / igfr / rtk / erk_mapk | 13_113159942_A_G / 8_28850143_T_G / 2_108507561_T_G / 16_30953637_A_C |
| 98 | HEXB_2 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 1012_Vorinostat_1 | mitosis / rtk / DNArep / other / chromatin | 11_65547388_T_G / 11_12162199_T_G |
| 99 | TGOLN2_3 | 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 156_AZD6482_2 | cell_cyc / metabol / pi3k / other / pi3k | 2_105307612_A_C / 7_72942379_A_C / 8_7290003_A_C |
| 100 | CBR3_5 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 276_CAY10603_3 | chromatin / mitosis / DNArep / other / chromatin | 8_30756677_T_G / 3_128945112_G_A / 12_6818898_A_C / 22_22098988_G_T / 2_60761746_T_G |
| 101 | C14orf93_1 | 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 263_FR-180204_3 / 253_XMD14-99_3 | chromatin / DNArep / igfr / erk_mapk / rtk | 20_42084724_T_C |
| 102 | ACVR1B_5 | 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1012_Vorinostat_1 / 281_Alectinib_2 | apop / mitosis / igfr / chromatin / rtk | 5_181155466_T_G / 11_12162199_T_G / 10_79312556_A_G / 2_113934259_C_T / 12_6818898_A_C |
| 103 | WNK2_1 | 1011_Navitoclax_2 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3 | apop / chromatin / DNArep / rtk / mitosis | 10_11921140_T_G |
| 104 | GBE1_5 | 1012_Vorinostat_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 | chromatin / rtk / mitosis / DNArep / other | 5_181155466_T_G / 16_58525116_G_T / 11_73355795_A_G / 10_11921140_T_G / 8_122952205_T_G |
| 105 | RAB27A_2 | 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 156_AZD6482_2 | cell_cyc / metabol / pi3k / other / pi3k | 8_7290003_A_C / 15_56464990_A_C |
| 106 | FAP_3 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 221_TAK-715_2 / 345_KIN001-270_3 | mitosis / DNArep / chromatin / jnk_p38 / cell_cyc | 17_55774876_T_G / 1_183963850_T_G / 11_94082585_T_C |
| 107 | THBS1_1 | 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 | cell_cyc / metabol / pi3k / other / abl | 8_7290003_A_C |
| 108 | RNF44_2 | 1012_Vorinostat_1 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 221_TAK-715_2 / 305_TPCA-1_3 | chromatin / igfr / DNArep / jnk_p38 / other | 8_12430448_C_T / 10_11921140_T_G |
| 109 | C2orf44_4 | 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 | igfr / mitosis / chromatin / other / DNArep | 7_108023984_G_A / 7_108024001_C_T / 11_65547388_T_G / 14_55169342_TAAA_T |
| 110 | ZSCAN2_1 | 304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 226_GSK1070916_2 | rtk / other / mitosis / igfr / mitosis | 2_61492168_C_A |
| 111 | PSMB8_3 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 275_I-BET-762_3 | mitosis / rtk / DNArep / igfr / chromatin | 11_12162199_T_G / X_2856636_A_C / 10_11921140_T_G |
| 112 | CTGF_2 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 | mitosis / chromatin / rtk / igfr / DNArep | 13_113159942_A_G / 2_188994726_T_G |
| 113 | DAP_1 | 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 | igfr / mitosis / chromatin / igfr / DNArep | 12_51745916_T_G |
| 114 | PHOX2A_1 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 185_Linsitinib_2 / 1091_BMS-536924_3 | mitosis / chromatin / DNArep / igfr / igfr | 12_51745916_T_G |
| 115 | MVP_2 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 / 253_XMD14-99_3 | mitosis / DNArep / chromatin / other / rtk | 12_40313960_G_T / 11_68785018_G_A |
| 116 | CCNJ_2 | 304_SB52334_3 / 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 / 305_TPCA-1_3 / 263_FR-180204_3 | rtk / mitosis / rtk / other / erk_mapk | 14_55169342_TAAA_T / 1_234373536_T_G |
| 117 | MAP4_5 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 / 1012_Vorinostat_1 / 221_TAK-715_2 | mitosis / rtk / other / chromatin / jnk_p38 | 16_81270082_T_G / 14_93183653_A_C / 1_54243266_A_G / 2_157299566_T_G / 16_58526137_A_C |
| 118 | ATP5B_2 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 305_TPCA-1_3 / 263_FR-180204_3 | chromatin / mitosis / igfr / other / erk_mapk | 1_54243266_A_G / 6_31966660_T_G |
| 119 | TRAM2_3 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 263_FR-180204_3 / 1091_BMS-536924_3 | mitosis / chromatin / rtk / erk_mapk / igfr | 11_12162199_T_G / 13_113159942_A_G / 12_40313960_G_T |
| 120 | CCDC107_5 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 263_FR-180204_3 | chromatin / other / mitosis / other / erk_mapk | 17_19414393_T_G / 11_1242476_T_G / 16_259458_T_G / 1_54243266_A_G / 1_171541102_T_G |
| 121 | SMARCAD1_5 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 | mitosis / other / rtk / igfr / igfr | 12_40313960_G_T / 15_65451964_A_G / 11_65547388_T_G / 6_30705792_T_G / 17_55774876_T_G |
| 122 | HRH1_1 | 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 263_FR-180204_3 | mitosis / igfr / chromatin / DNArep / erk_mapk | 9_108900415_C_A |
| 123 | KHDRBS1_2 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 257_NPK76-II-72-1_3 | chromatin / other / mitosis / igfr / mitosis | 5_181155466_T_G / 12_6818898_A_C |
| 124 | E2F6_3 | 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 184_BMS-754807_2 / 305_TPCA-1_3 | igfr / mitosis / erk_mapk / igfr / other | 1_248122139_G_T / 1_248122185_A_G / 12_109800676_G_A |
| 125 | ELL2_2 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 1091_BMS-536924_3 / 305_TPCA-1_3 | chromatin / mitosis / erk_mapk / igfr / other | 10_73803531_T_C / 5_181155466_T_G |
| 126 | BSN_2 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 281_Alectinib_2 | mitosis / igfr / other / DNArep / rtk | 16_1817242_T_C / 13_113159942_A_G |
| 127 | ATG4A_5 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 253_XMD14-99_3 / 226_GSK1070916_2 | chromatin / other / rtk / mitosis | 2_61492168_C_A / 2_113934259_C_T / 9_108900415_C_A / 16_87644643_G_A / 9_35398502_T_G |
| 128 | CD44_4 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 | chromatin / other / mitosis / igfr | 12_40313960_G_T / 15_75524142_T_C / 12_51745916_T_G / 2_113934259_C_T |
| 129 | GSN_5 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 | chromatin / mitosis / apop / DNArep | 10_11921140_T_G / 13_113159942_A_G / 5_181155466_T_G / 16_1817242_T_C / 15_75524142_T_C |
| 130 | CD99_5 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 304_SB52334_3 | mitosis / apop / DNArep / rtk | 16_1817242_T_C / 11_65547388_T_G / 11_12162199_T_G / 5_181155466_T_G / 10_11921140_T_G |
| 131 | GNAI2_5 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 1011_Navitoclax_2 | mitosis / rtk / chromatin / apop | 1_149852603_A_G / 1_150261398_T_G / 17_55774876_T_G / 1_154627925_A_C / 17_77213881_T_G |
| 132 | DDX60_5 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 | mitosis / rtk / DNArep / other | 11_12162199_T_G / 16_87644643_G_A / 2_108507561_T_G / 5_181155466_T_G / 1_26774532_T_C |
| 133 | MICALL2_3 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 263_FR-180204_3 | mitosis / chromatin / DNArep / erk_mapk | 16_30953637_A_C / 11_12162199_T_G / 12_51745916_T_G |
| 134 | SOAT1_5 | 185_Linsitinib_2 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 | igfr / rtk / mitosis / other | 5_181155466_T_G / 5_38950065_A_T / 12_40313960_G_T / 17_51169925_C_T / 2_61492168_C_A |
| 135 | PLEC_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 51_Dasatinib_1 / 94_TGX221_3 | cell_cyc / other / abl / pi3k | 7_72942379_A_C |
| 136 | XRCC5_1 | 253_XMD14-99_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | rtk / erk_mapk / mitosis / DNArep | 20_42084724_T_C |
| 137 | OSGEPL1_1 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 253_XMD14-99_3 | erk_mapk / mitosis / chromatin / rtk | 12_40313960_G_T |
| 138 | TMEM97_4 | 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 1012_Vorinostat_1 / 300_CX-5461_3 | DNArep / apop / chromatin / other | 17_55774876_T_G / 20_33848655_A_C / 1_150261398_T_G / 12_6818898_A_C |
| 139 | GLIS3_4 | 185_Linsitinib_2 / 1091_BMS-536924_3 / 184_BMS-754807_2 / 1012_Vorinostat_1 | igfr / igfr / igfr / chromatin | 11_65547388_T_G / 2_66439901_A_C / 10_50311228_T_G / 8_41957277_G_C |
| 140 | ANXA1_5 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1012_Vorinostat_1 / 185_Linsitinib_2 | mitosis / rtk / chromatin / igfr | 12_51745916_T_G / 5_181155466_T_G / 10_11921140_T_G / 13_113159942_A_G / 16_1817242_T_C |
| 141 | FAM120A_5 | 179_5-Fluorouracil_1 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 | DNArep / rtk / mitosis / other | 13_113159942_A_G / 3_128945112_G_A / 12_123499406_T_G / 20_42084724_T_C / 6_30705792_T_G |
| 142 | SAFB_3 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 / 305_TPCA-1_3 | mitosis / chromatin / rtk / other | 13_113159942_A_G / 14_55169342_TAAA_T / 10_11921140_T_G |
| 143 | ACTN4_4 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 | mitosis / rtk / igfr / DNArep | 11_12162199_T_G / 12_51745916_T_G / 10_73803641_A_G / 1_213007133_T_G |
| 144 | FAM117B_5 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 300_CX-5461_3 | DNArep / mitosis / chromatin / other | 5_181155466_T_G / 13_113159942_A_G / 1_15381304_A_C / 17_55774876_T_G / 10_11921140_T_G |
| 145 | TSSC1_1 | 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 263_FR-180204_3 | igfr / mitosis / igfr / erk_mapk | 2_113934259_C_T |
| 146 | SERPINE2_1 | 94_TGX221_3 / 56_WH-4-023_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 | pi3k / abl / cell_cyc / other | 7_72942379_A_C |
| 147 | IFNAR1_5 | 263_FR-180204_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | erk_mapk / chromatin / mitosis / DNArep | 15_84241166_A_C / 6_30642116_A_G / 19_4911043_A_C / 16_259458_T_G / 19_7740447_T_G |
| 148 | UEVLD_3 | 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 | DNArep / chromatin / mitosis / rtk | 10_11921140_T_G / 11_43920052_A_C / X_2856636_A_C |
| 149 | GUF1_5 | 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 | mitosis / igfr / DNArep / chromatin | 11_65547388_T_G / 5_181155466_T_G / 1_213007133_T_G / 11_12162199_T_G / 17_55774876_T_G |
| 150 | GBP3_1 | 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 | cell_cyc / pi3k / metabol / other | 8_7290003_A_C |
| 151 | MED28_1 | 94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 196_Phenformin_3 | pi3k / cell_cyc / pi3k / metabol | 8_7290003_A_C |
| 152 | SLC2A10_1 | 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 | cell_cyc / pi3k / metabol / other | 8_7290003_A_C |
| 153 | CBR3_1 | 94_TGX221_3 / 1026_Tanespimycin_2 / 344_THZ-2-49_3 / 196_Phenformin_3 | pi3k / other / cell_cyc / metabol | 8_7290003_A_C |
| 154 | HIC2_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 94_TGX221_3 | cell_cyc / other / metabol / pi3k | 8_7290003_A_C |
| 155 | IGSF9_1 | 1026_Tanespimycin_2 / 94_TGX221_3 / 196_Phenformin_3 / 344_THZ-2-49_3 | other / pi3k / metabol / cell_cyc | 8_7290003_A_C |
| 156 | RCAN1_1 | 344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 / 94_TGX221_3 | cell_cyc / metabol / other / pi3k | 8_7290003_A_C |
| 157 | SAFB_1 | 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 | metabol / cell_cyc / pi3k / other | 8_7290003_A_C |
| 158 | HNRNPA0_2 | 1012_Vorinostat_1 / 293_Amuvatinib_2 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 | chromatin / rtk / DNArep / apop | 17_55774876_T_G / 16_55415_T_G |
| 159 | ISL1_1 | 196_Phenformin_3 / 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 | metabol / pi3k / cell_cyc / other | 7_72942379_A_C |
| 160 | PPIC_1 | 1012_Vorinostat_1 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 | chromatin / igfr / mitosis / erk_mapk | 2_66439901_A_C |
| 161 | CBX1_1 | 1011_Navitoclax_2 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 | apop / other / DNArep / mitosis | 20_42084724_T_C |
| 162 | ARID3B_1 | 1026_Tanespimycin_2 / 156_AZD6482_2 / 344_THZ-2-49_3 / 196_Phenformin_3 | other / pi3k / cell_cyc / metabol | 8_7290003_A_C |
| 163 | RNF157_1 | 1011_Navitoclax_2 / 179_5-Fluorouracil_1 / 281_Alectinib_2 / 304_SB52334_3 | apop / DNArep / rtk / rtk | 10_11921140_T_G |
| 164 | EIF3L_2 | 1012_Vorinostat_1 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 | chromatin / igfr / DNArep / mitosis | 17_51169925_C_T / 20_42084724_T_C |
| 165 | SLC25A43_2 | 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 / 344_THZ-2-49_3 | pi3k / other / metabol / cell_cyc | 8_7290003_A_C / 19_7627786_T_G |
| 166 | OLFML2A_1 | 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 51_Dasatinib_1 | metabol / cell_cyc / pi3k / abl | 7_72942379_A_C |
| 167 | HNRNPA1L2_4 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 305_TPCA-1_3 / 1012_Vorinostat_1 | mitosis / apop / other / chromatin | 2_113934259_C_T / 12_40313960_G_T / 5_181155466_T_G / 12_51745916_T_G |
| 168 | GPR125_1 | 1011_Navitoclax_2 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 | apop / rtk / mitosis / other | 5_181155466_T_G |
| 169 | HFM1_5 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 | mitosis / rtk / apop / DNArep | 6_73622013_G_C / 6_73635330_C_T / 10_79312556_A_G / 15_55340661_G_T / 11_12162199_T_G |
| 170 | FAM161A_3 | 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 / 1009_Tretinoin_1 | DNArep / other / apop / other | 3_165019547_G_T / 11_65547388_T_G / 7_100104762_T_G |
| 171 | MYO1E_5 | 1012_Vorinostat_1 / 1091_BMS-536924_3 / 281_Alectinib_2 / 221_TAK-715_2 | chromatin / igfr / rtk / jnk_p38 | 12_51745916_T_G / 2_113934259_C_T / 15_40767895_T_G / 8_41957277_G_C / 2_157299566_T_G |
| 172 | BHLHE40_2 | 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 / 156_AZD6482_2 | cell_cyc / metabol / pi3k / pi3k | 7_72942379_A_C / 8_7290003_A_C |
| 173 | IPO9_1 | 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 300_CX-5461_3 / 275_I-BET-762_3 | DNArep / chromatin / other / chromatin | 12_51745916_T_G |
| 174 | MALT1_5 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 1091_BMS-536924_3 | erk_mapk / mitosis / chromatin / igfr | 11_12162199_T_G / 19_4911043_A_C / 12_40313960_G_T / 8_122952205_T_G / 17_7797836_A_C |
| 175 | GDPD1_1 | 179_5-Fluorouracil_1 / 226_GSK1070916_2 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 | DNArep / mitosis / other / mitosis | 9_69516199_A_C |
| 176 | CLIC1_5 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 1091_BMS-536924_3 | mitosis / rtk / DNArep / igfr | 16_1817242_T_C / 13_113159942_A_G / 6_30705800_T_G / 3_128945112_G_A / 5_181155466_T_G |
| 177 | GBP1_1 | 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 185_Linsitinib_2 / 304_SB52334_3 | mitosis / igfr / igfr / rtk | 11_12162199_T_G |
| 178 | WDR1_4 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 / 221_TAK-715_2 | mitosis / rtk / DNArep / jnk_p38 | 13_113159942_A_G / 16_1817242_T_C / 18_79527652_GAA_G / 10_11921140_T_G |
| 179 | NOLC1_1 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 305_TPCA-1_3 | chromatin / mitosis / erk_mapk / other | 1_234373536_T_G |
| 180 | SUCLG2_1 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 304_SB52334_3 / 305_TPCA-1_3 | mitosis / apop / rtk / other | 2_113934259_C_T |
| 181 | TMEM50B_4 | 1012_Vorinostat_1 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 | chromatin / erk_mapk / mitosis / mitosis | 15_84241166_A_C / 6_30642116_A_G / 12_40313960_G_T / 10_27223356_T_C |
| 182 | TEP1_2 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 | mitosis / other / DNArep / other | 13_113159942_A_G / 1_160801918_G_C |
| 183 | C1QTNF4_1 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 300_CX-5461_3 / 304_SB52334_3 | DNArep / mitosis / other / rtk | 2_108507561_T_G |
| 184 | SAMD9_2 | 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1 | mitosis / rtk / igfr / chromatin | 11_12162199_T_G / 5_181155466_T_G |
| 185 | INTS2_1 | 226_GSK1070916_2 / 1012_Vorinostat_1 / 225_Genentech Cpd 10_3 / 305_TPCA-1_3 | mitosis / chromatin / mitosis / other | 20_42084724_T_C |
| 186 | FUBP1_1 | 253_XMD14-99_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 | rtk / DNArep / mitosis / chromatin | 16_28169801_A_C |
| 187 | RPAP1_1 | 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 304_SB52334_3 / 1012_Vorinostat_1 | mitosis / igfr / rtk / chromatin | 2_96842345_G_C |
| 188 | HEXB_1 | 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 | metabol / cell_cyc / pi3k / other | 15_75876091_T_G |
| 189 | HNRNPU_1 | 305_TPCA-1_3 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 269_NSC-207895_3 | other / chromatin / mitosis / p53 | 15_65451964_A_G |
| 190 | FUCA1_2 | 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 | mitosis / chromatin / chromatin / DNArep | 1_153341603_A_C / 11_12162199_T_G |
| 191 | NOTCH2_2 | 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 | rtk / mitosis / other / igfr | 11_65547388_T_G / 13_113159942_A_G |
| 192 | CCT4_1 | 1012_Vorinostat_1 / 276_CAY10603_3 / 179_5-Fluorouracil_1 / 269_NSC-207895_3 | chromatin / chromatin / DNArep / p53 | 7_108023984_G_A |
| 193 | UTRN_3 | 1012_Vorinostat_1 / 263_FR-180204_3 / 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 | chromatin / erk_mapk / igfr / mitosis | 7_108023984_G_A / 17_80962613_A_C / 19_4911043_A_C |
| 194 | CALU_1 | 94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 / 1026_Tanespimycin_2 | pi3k / cell_cyc / pi3k / other | 7_72942379_A_C |
| 195 | PLAUR_1 | 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 / 196_Phenformin_3 | cell_cyc / pi3k / other / metabol | 7_72942379_A_C |
| 196 | HIST1H3F_2 | 1012_Vorinostat_1 / 281_Alectinib_2 / 263_FR-180204_3 / 179_5-Fluorouracil_1 | chromatin / rtk / erk_mapk / DNArep | 9_35398502_T_G / 4_88731303_A_G |
| 197 | SHF_2 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 / 1012_Vorinostat_1 | mitosis / rtk / igfr / chromatin | 2_108507561_T_G / 7_149432379_A_C |
| 198 | CERK_1 | 281_Alectinib_2 / 1011_Navitoclax_2 / 300_CX-5461_3 / 253_XMD14-99_3 | rtk / apop / other / rtk | 2_29320789_A_C |
| 199 | TADA1_1 | 344_THZ-2-49_3 / 156_AZD6482_2 / 159_HG6-64-1_3 / 94_TGX221_3 | cell_cyc / pi3k / erk_mapk / pi3k | 18_41955194_A_G |
| 200 | UBA7_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 | mitosis / other / DNArep / rtk | 3_128945112_G_A |
| 201 | SETDB1_1 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 253_XMD14-99_3 | DNArep / mitosis / chromatin / rtk | 10_11921140_T_G |
| 202 | FEV_1 | 196_Phenformin_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 1057_Dactolisib_2 | metabol / cell_cyc / other / pi3k | 2_105307612_A_C |
| 203 | PLIN3_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 281_Alectinib_2 / 185_Linsitinib_2 | mitosis / rtk / rtk / igfr | 11_12162199_T_G |
| 204 | CAPZB_1 | 253_XMD14-99_3 / 300_CX-5461_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 | rtk / other / DNArep / mitosis | 8_109289769_T_C |
| 205 | PRR14L_1 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 | mitosis / DNArep / other / other | 11_65547388_T_G |
| 206 | SYT4_1 | 281_Alectinib_2 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 1091_BMS-536924_3 | rtk / mitosis / igfr / igfr | 1_247949628_T_C |
| 207 | OSTM1_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 293_Amuvatinib_2 | mitosis / other / igfr / rtk | 11_12162199_T_G |
| 208 | ALKBH2_5 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 293_Amuvatinib_2 | chromatin / mitosis / igfr / rtk | 11_12162199_T_G / 19_3281403_A_C / 1_228244520_T_G / 16_30953637_A_C / 8_27431326_A_G |
| 209 | MSN_1 | 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 185_Linsitinib_2 | igfr / DNArep / chromatin / igfr | 10_73803641_A_G |
| 210 | ESYT2_2 | 1012_Vorinostat_1 / 281_Alectinib_2 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 | chromatin / rtk / igfr / DNArep | 10_73803641_A_G / 19_4911043_A_C |
| 211 | RSBN1_1 | 304_SB52334_3 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 / 300_CX-5461_3 | rtk / DNArep / other / other | 13_113159942_A_G |
| 212 | ATL3_1 | 179_5-Fluorouracil_1 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 / 185_Linsitinib_2 | DNArep / other / mitosis / igfr | 13_113159942_A_G |
| 213 | GLCCI1_2 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 / 281_Alectinib_2 | mitosis / rtk / igfr / rtk | 16_1817242_T_C / 13_113159942_A_G |
| 214 | STX4_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 179_5-Fluorouracil_1 | mitosis / other / rtk / DNArep | 13_113159942_A_G |
| 215 | ZFP36_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 | mitosis / other / DNArep / rtk | 13_113159942_A_G |
| 216 | ITPR3_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3 / 196_Phenformin_3 | cell_cyc / other / pi3k / metabol | 20_33072178_T_G |
| 217 | APEX1_1 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 293_Amuvatinib_2 / 275_I-BET-762_3 | chromatin / other / rtk / chromatin | 17_55774876_T_G |
| 218 | NAGK_1 | 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 305_TPCA-1_3 | chromatin / DNArep / apop / other | X_2856636_A_C |
| 219 | CTSO_2 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 300_CX-5461_3 | DNArep / mitosis / erk_mapk / other | 8_2963284_T_G / 19_6937330_T_G |
| 220 | GAL3ST3_5 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 | mitosis / other / rtk | 16_55415_T_G / X_100585180_G_T / 10_79312556_A_G / 19_7740447_T_G / 1_228244520_T_G |
| 221 | UBA52_3 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 | mitosis / chromatin / other | 13_113159942_A_G / 12_40313960_G_T / 11_65547388_T_G |
| 222 | MSRB3_4 | 304_SB52334_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 | rtk / DNArep / mitosis | 11_65547388_T_G / 2_108507561_T_G / 12_99655061_T_A / 13_113159942_A_G |
| 223 | MTPAP_3 | 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 | DNArep / chromatin / mitosis | 1_150261398_T_G / 11_65547388_T_G / 9_128964364_CT_C |
| 224 | UBE2O_4 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 304_SB52334_3 | chromatin / mitosis / rtk | 20_42084724_T_C / 10_11921140_T_G / 6_30705800_T_G / 1_155747580_A_G |
| 225 | RANBP17_1 | 304_SB52334_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 | rtk / mitosis / rtk | 20_42084724_T_C |
| 226 | ZNF516_4 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 | DNArep / mitosis / other | 17_55774876_T_G / 9_37887606_C_T / 3_184301903_T_G / 1_234373536_T_G |
| 227 | NKAIN1_3 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 305_TPCA-1_3 | mitosis / rtk / other | 12_40313960_G_T / 13_113159942_A_G / 20_42084724_T_C |
| 228 | DHX9_3 | 269_NSC-207895_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 | p53 / other / mitosis | 2_113934259_C_T / 15_65451964_A_G / 7_44964464_T_C |
| 229 | TET1_4 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 | mitosis / rtk / igfr | 15_40767895_T_G / 12_51745916_T_G / 2_188994726_T_G / 17_55774876_T_G |
| 230 | UHMK1_1 | 310_YM201636_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 | other / other / mitosis | 8_30756677_T_G |
| 231 | KCNH8_2 | 94_TGX221_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 | pi3k / metabol / other | 7_72942379_A_C / 20_62661184_C_T |
| 232 | PMEL_1 | 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 263_FR-180204_3 | mitosis / rtk / erk_mapk | 20_42084724_T_C |
| 233 | TMEM177_2 | 1012_Vorinostat_1 / 253_XMD14-99_3 / 211_TL-2-105_3 | chromatin / rtk / erk_mapk | 12_40313960_G_T / 9_108900415_C_A |
| 234 | P4HB_3 | 305_TPCA-1_3 / 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 | other / apop / mitosis | 6_30329265_T_C / 2_113934259_C_T / 6_39884042_G_A |
| 235 | GLB1_2 | 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 | other / mitosis / rtk | 1_219979389_T_A / 1_54243266_A_G |
| 236 | NIPSNAP1_5 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | chromatin / mitosis / DNArep | 2_86027990_C_A / 5_181155466_T_G / 2_60761746_T_G / 9_37887606_C_T / 12_51745916_T_G |
| 237 | STOX2_4 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 304_SB52334_3 | mitosis / igfr / rtk | 13_113159942_A_G / 11_65547388_T_G / 17_44212322_A_G / 16_1817242_T_C |
| 238 | HIC2_5 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | chromatin / mitosis / DNArep | 11_12162199_T_G / 10_11921140_T_G / 5_181155466_T_G / 1_54243266_A_G / 14_67381608_G_T |
| 239 | DDX25_1 | 344_THZ-2-49_3 / 94_TGX221_3 / 1026_Tanespimycin_2 | cell_cyc / pi3k / other | 7_72942379_A_C |
| 240 | DNMT3A_1 | 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 | cell_cyc / pi3k / metabol | 7_72942379_A_C |
| 241 | EXT2_1 | 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 | cell_cyc / pi3k / metabol | 7_72942379_A_C |
| 242 | FAM129B_1 | 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 | pi3k / cell_cyc / other | 7_72942379_A_C |
| 243 | GINM1_1 | 344_THZ-2-49_3 / 94_TGX221_3 / 196_Phenformin_3 | cell_cyc / pi3k / metabol | 7_72942379_A_C |
| 244 | HNRNPA1L2_1 | 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 | pi3k / cell_cyc / other | 7_72942379_A_C |
| 245 | MAN1B1_1 | 94_TGX221_3 / 196_Phenformin_3 / 344_THZ-2-49_3 | pi3k / metabol / cell_cyc | 7_72942379_A_C |
| 246 | TACC1_1 | 344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 | cell_cyc / metabol / other | 7_72942379_A_C |
| 247 | RIPK1_5 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 | mitosis / DNArep / rtk | 11_12162199_T_G / 1_234373536_T_G / 2_190469793_G_C / 16_1817242_T_C / 11_65547388_T_G |
| 248 | ZBTB4_3 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 | mitosis / chromatin / DNArep | 17_55774876_T_G / 10_11921140_T_G / 6_30705792_T_G |
| 249 | TLN1_5 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 | mitosis / DNArep / rtk | 15_43578884_A_G / 13_113159942_A_G / 3_128945112_G_A / 11_12162199_T_G / 19_4911043_A_C |
| 250 | PCBP3_1 | 94_TGX221_3 / 51_Dasatinib_1 / 196_Phenformin_3 | pi3k / abl / metabol | 7_72942379_A_C |
| 251 | KIDINS220_2 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 305_TPCA-1_3 | mitosis / igfr / other | 2_113934259_C_T / 1_113549504_C_T |
| 252 | MYH9_4 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 179_5-Fluorouracil_1 | mitosis / chromatin / DNArep | 9_69516199_A_C / 13_113159942_A_G / 1_15381304_A_C / 10_11921140_T_G |
| 253 | C2orf43_4 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 185_Linsitinib_2 | mitosis / erk_mapk / igfr | 19_3281403_A_C / 20_42084724_T_C / 12_109800676_G_A / 7_108023984_G_A |
| 254 | CFLAR_5 | 1012_Vorinostat_1 / 304_SB52334_3 / 275_I-BET-762_3 | chromatin / rtk / chromatin | 17_55774876_T_G / 7_108023984_G_A / 5_181155466_T_G / 1_228244520_T_G / 5_38950065_A_T |
| 255 | RAB27A_5 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 | chromatin / mitosis / other | 12_6818898_A_C / 16_20737706_A_C / 2_66439901_A_C / 5_181155466_T_G / 11_12162199_T_G |
| 256 | PLSCR4_2 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 304_SB52334_3 | mitosis / erk_mapk / rtk | 16_55415_T_G / 17_51169925_C_T |
| 257 | RPUSD4_1 | 293_Amuvatinib_2 / 1012_Vorinostat_1 / 1091_BMS-536924_3 | rtk / chromatin / igfr | 15_75524142_T_C |
| 258 | MPST_3 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 | DNArep / mitosis / chromatin | 17_18353665_C_T / 1_150261398_T_G / 5_181155466_T_G |
| 259 | MSN_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3 | cell_cyc / other / pi3k | 8_7290003_A_C |
| 260 | TGFB1I1_1 | 1026_Tanespimycin_2 / 94_TGX221_3 / 344_THZ-2-49_3 | other / pi3k / cell_cyc | 8_7290003_A_C |
| 261 | PRMT1_2 | 1012_Vorinostat_1 / 263_FR-180204_3 / 221_TAK-715_2 | chromatin / erk_mapk / jnk_p38 | 1_26034759_T_G / 5_181155466_T_G |
| 262 | AGPAT3_3 | 179_5-Fluorouracil_1 / 275_I-BET-762_3 / 265_Tubastatin A_3 | DNArep / chromatin / chromatin | 11_65547388_T_G / 1_183963850_T_G / 13_113159942_A_G |
| 263 | NUPR1_2 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 272_AR-42_2 | mitosis / other / chromatin | 11_20049928_A_C / 12_40313960_G_T |
| 264 | RNPC3_2 | 265_Tubastatin A_3 / 179_5-Fluorouracil_1 / 276_CAY10603_3 | chromatin / DNArep / chromatin | 20_5501817_T_G / 17_55774876_T_G |
| 265 | S100A6_2 | 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 | cell_cyc / metabol / pi3k | 8_7290003_A_C / 7_72942379_A_C |
| 266 | GADD45B_2 | 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 1012_Vorinostat_1 | mitosis / chromatin / chromatin | 12_51745916_T_G / 11_12162199_T_G |
| 267 | IRF2_2_5 | 294_MPS-1-IN-1_3 / 269_NSC-207895_3 / 293_Amuvatinib_2 | mitosis / p53 / rtk | 1_149852603_A_G / 1_219979389_T_A |
| 268 | MVP_2_3 | 94_TGX221_3 / 344_THZ-2-49_3 / 196_Phenformin_3 | pi3k / cell_cyc / metabol | 11_68780792_C_A / 15_75876091_T_G |
| 269 | GTF2H5_2 | 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 184_BMS-754807_2 | mitosis / igfr / igfr | 3_165019547_G_T / 16_15664675_G_T |
| 270 | AGTPBP1_2 | 179_5-Fluorouracil_1 / 300_CX-5461_3 / 294_MPS-1-IN-1_3 | DNArep / other / mitosis | 13_113159942_A_G / 11_65547388_T_G |
| 271 | TAGLN2_5 | 1091_BMS-536924_3 / 1011_Navitoclax_2 / 304_SB52334_3 | igfr / apop / rtk | 5_181155466_T_G / 12_7433515_G_T / 15_75524142_T_C / 20_2862756_T_G / 19_47441156_T_G |
| 272 | CCNT1_4 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 269_NSC-207895_3 | chromatin / other / p53 | 1_197912561_T_G / 5_115984518_A_T / 8_98032165_T_G / 15_65451964_A_G |
| 273 | KCNN4_1 | 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 | metabol / cell_cyc / pi3k | 8_7290003_A_C |
| 274 | PEA15_1 | 196_Phenformin_3 / 94_TGX221_3 / 344_THZ-2-49_3 | metabol / pi3k / cell_cyc | 8_7290003_A_C |
| 275 | SAMD9_1 | 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 | metabol / cell_cyc / pi3k | 8_7290003_A_C |
| 276 | TRADD_3 | 179_5-Fluorouracil_1 / 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 | DNArep / apop / mitosis | 10_11921140_T_G / 13_113159942_A_G / 16_1817242_T_C |
| 277 | TAF5_3 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 304_SB52334_3 | mitosis / chromatin / rtk | 6_33799054_A_G / 19_3281403_A_C / 7_108023984_G_A |
| 278 | EFHD2_4 | 1091_BMS-536924_3 / 304_SB52334_3 / 281_Alectinib_2 | igfr / rtk / rtk | 12_51745916_T_G / 1_213007133_T_G / 1_451649_A_AG / 2_61492168_C_A |
| 279 | YIPF2_1 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 1011_Navitoclax_2 | mitosis / erk_mapk / apop | 2_113934259_C_T |
| 280 | ZBED4_2 | 1012_Vorinostat_1 / 305_TPCA-1_3 / 1011_Navitoclax_2 | chromatin / other / apop | 2_108507561_T_G / 11_65547388_T_G |
| 281 | RAB3C_1 | 1026_Tanespimycin_2 / 196_Phenformin_3 / 344_THZ-2-49_3 | other / metabol / cell_cyc | 8_7290003_A_C |
| 282 | FOSL1_4 | 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 275_I-BET-762_3 | other / DNArep / chromatin | 12_57062993_T_G / 12_51745916_T_G / 13_39724512_C_T / 1_213007133_T_G |
| 283 | INA_2 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 | mitosis / rtk / erk_mapk | 13_113159942_A_G / 16_1817242_T_C |
| 284 | FLVCR1_2 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 253_XMD14-99_3 | mitosis / DNArep / rtk | 10_11921140_T_G / 11_12162199_T_G |
| 285 | ATF7IP2_5 | 1264_SGC0946_3 / 293_Amuvatinib_2 / 151_QS11_3 | chromatin / rtk / other | 17_55774876_T_G / 10_73803531_T_C / 2_63887264_C_CA / 3_9789934_A_C / 1_149852603_A_G |
| 286 | S100A10_1 | 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 304_SB52334_3 | mitosis / rtk / rtk | 10_11921140_T_G |
| 287 | TRIP6_1 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 | chromatin / mitosis / igfr | 12_51745916_T_G |
| 288 | EIF3J_2 | 1012_Vorinostat_1 / 257_NPK76-II-72-1_3 / 269_NSC-207895_3 | chromatin / mitosis / p53 | 17_36429365_A_G / 1_237687398_C_T |
| 289 | CASP4_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 275_I-BET-762_3 | mitosis / rtk / chromatin | 12_51745916_T_G |
| 290 | NSL1_2 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 1012_Vorinostat_1 | mitosis / apop / chromatin | 11_12162199_T_G / 10_11921140_T_G |
| 291 | VASP_1 | 304_SB52334_3 / 294_MPS-1-IN-1_3 / 253_XMD14-99_3 | rtk / mitosis / rtk | 11_12162199_T_G |
| 292 | COG2_3 | 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | rtk / mitosis / DNArep | 10_11921140_T_G / 16_87644643_G_A / 3_53891822_C_T |
| 293 | STMN4_3 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 263_FR-180204_3 | mitosis / igfr / erk_mapk | 13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C |
| 294 | ARID2_1 | 304_SB52334_3 / 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 | rtk / mitosis / chromatin | 11_12162199_T_G |
| 295 | TMEM145_2 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 179_5-Fluorouracil_1 | mitosis / igfr / DNArep | 10_11921140_T_G / 11_34452090_T_G |
| 296 | RPS28_2 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 305_TPCA-1_3 | mitosis / chromatin / other | 15_43578884_A_G / 17_18282629_T_G |
| 297 | BHLHB9_5 | 300_CX-5461_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 | other / apop / DNArep | 2_224001859_C_A / 2_224001670_G_A / 3_128908178_A_G / 13_113159942_A_G / 3_128908109_T_C |
| 298 | CCT3_2 | 94_TGX221_3 / 344_THZ-2-49_3 / 156_AZD6482_2 | pi3k / cell_cyc / pi3k | 1_146969331_G_A / 1_16589114_C_T |
| 299 | ZBTB39_1 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 1012_Vorinostat_1 | mitosis / DNArep / chromatin | 16_30953637_A_C |
| 300 | TGFBI_1 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 / 253_XMD14-99_3 | DNArep / mitosis / rtk | 11_12162199_T_G |
| 301 | DRAM1_2 | 294_MPS-1-IN-1_3 / 275_I-BET-762_3 / 179_5-Fluorouracil_1 | mitosis / chromatin / DNArep | 13_113159942_A_G / 12_40313960_G_T |
| 302 | TTC9B_4 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 185_Linsitinib_2 | mitosis / rtk / igfr | 16_30953637_A_C / 16_1817242_T_C / 13_113159942_A_G / 3_128945112_G_A |
| 303 | CRABP1_2 | 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 263_FR-180204_3 | mitosis / igfr / erk_mapk | 12_40313960_G_T / 9_69516199_A_C |
| 304 | PRNP_1 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 275_I-BET-762_3 | mitosis / igfr / chromatin | 12_51745916_T_G |
| 305 | RNF216_2 | 344_THZ-2-49_3 / 156_AZD6482_2 / 199_Pazopanib_2 | cell_cyc / pi3k / rtk | 2_230310834_T_C / 2_230401046_T_C |
| 306 | KCNH2_1 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 | mitosis / chromatin / erk_mapk | 5_38950065_A_T |
| 307 | HDAC2_1 | 344_THZ-2-49_3 / 196_Phenformin_3 / 94_TGX221_3 | cell_cyc / metabol / pi3k | 15_75876091_T_G |
| 308 | LDLRAD3_2 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 | mitosis / apop / DNArep | 11_65547388_T_G / 1_112653581_C_T |
| 309 | DLG2_1 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 / 263_FR-180204_3 | mitosis / chromatin / erk_mapk | 8_30756677_T_G |
| 310 | ABHD2_2 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 | mitosis / other / rtk | 20_31465452_G_A / 20_31476528_A_G |
| 311 | FICD_1 | 305_TPCA-1_3 / 310_YM201636_3 / 275_I-BET-762_3 | other / other / chromatin | 12_40313960_G_T |
| 312 | EML5_1 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 / 304_SB52334_3 | mitosis / igfr / rtk | 19_3281403_A_C |
| 313 | ZNF280B_1 | 179_5-Fluorouracil_1 / 300_CX-5461_3 / 1011_Navitoclax_2 | DNArep / other / apop | 11_65547388_T_G |
| 314 | MAST1_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 1091_BMS-536924_3 | mitosis / rtk / igfr | 10_11921140_T_G |
| 315 | NBR2_4 | 1012_Vorinostat_1 / 221_TAK-715_2 / 226_GSK1070916_2 | chromatin / jnk_p38 / mitosis | 7_142944295_A_G / 7_142939444_T_G / 7_142939502_G_A / 19_3179506_A_C |
| 316 | ZSCAN16_1 | 94_TGX221_3 / 344_THZ-2-49_3 / 1026_Tanespimycin_2 | pi3k / cell_cyc / other | 16_72119226_C_G |
| 317 | CD109_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 | mitosis / other / rtk | 10_11921140_T_G |
| 318 | ASCL1_1 | 94_TGX221_3 / 196_Phenformin_3 / 156_AZD6482_2 | pi3k / metabol / pi3k | 7_72942379_A_C |
| 319 | PRCC_2 | 344_THZ-2-49_3 / 94_TGX221_3 / 156_AZD6482_2 | cell_cyc / pi3k / pi3k | 2_105307612_A_C / 19_8943580_T_G |
| 320 | SYPL1_3 | 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 / 179_5-Fluorouracil_1 | mitosis / igfr / DNArep | 16_1817242_T_C / 3_128945112_G_A / 1_150261398_T_G |
| 321 | CACNA1B_3 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 / 179_5-Fluorouracil_1 | mitosis / apop / DNArep | 13_113159942_A_G / X_2856636_A_C / 16_1817242_T_C |
| 322 | FEV_3 | 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 184_BMS-754807_2 | igfr / mitosis / igfr | 16_1817242_T_C / 13_113159942_A_G / 2_71515762_T_C |
| 323 | VSTM2A_2 | 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 179_5-Fluorouracil_1 | mitosis / rtk / DNArep | 13_113159942_A_G / 16_1817242_T_C |
| 324 | DOC2A_1 | 179_5-Fluorouracil_1 / 304_SB52334_3 / 294_MPS-1-IN-1_3 | DNArep / rtk / mitosis | 22_42212334_A_C |
| 325 | MTR_1 | 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 | rtk / mitosis / rtk | 2_61492168_C_A |
| 326 | TMEM184B_1 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 269_NSC-207895_3 | chromatin / mitosis / p53 | 13_113159942_A_G |
| 327 | ARID2_3 | 344_THZ-2-49_3 / 196_Phenformin_3 / 1026_Tanespimycin_2 | cell_cyc / metabol / other | 16_72129067_G_T / 16_72164743_G_A / 16_72119226_C_G |
| 328 | TSEN54_2 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 | chromatin / mitosis / rtk | 13_113325635_A_G / 11_12162199_T_G |
| 329 | LAMP2_1 | 1091_BMS-536924_3 / 1012_Vorinostat_1 / 263_FR-180204_3 | igfr / chromatin / erk_mapk | 6_33279455_T_G |
| 330 | GPX8_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 / 94_TGX221_3 | cell_cyc / other / pi3k | 16_72119226_C_G |
| 331 | PRIM1_1 | 1011_Navitoclax_2 / 1012_Vorinostat_1 / 288_WHI-P97_3 | apop / chromatin / other | 2_218827668_A_C |
| 332 | MMD_3 | 1012_Vorinostat_1 / 281_Alectinib_2 / 294_MPS-1-IN-1_3 | chromatin / rtk / mitosis | 1_248441636_T_G / 8_122952205_T_G / 6_30705792_T_G |
| 333 | HSPD1_1 | 1012_Vorinostat_1 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 | chromatin / erk_mapk / mitosis | 17_55774876_T_G |
| 334 | TNFRSF12A_5 | 1091_BMS-536924_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 | igfr / DNArep / mitosis | 2_60761746_T_G / 11_12162199_T_G / 5_181155466_T_G / 10_50311228_T_G / 13_113159942_A_G |
| 335 | PLP2_4 | 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 | igfr / mitosis / apop | 8_30756677_T_G / 5_181155466_T_G / 12_104287190_A_G / 6_33296240_C_A |
| 336 | SNX3_1 | 294_MPS-1-IN-1_3 / 253_XMD14-99_3 / 226_GSK1070916_2 | mitosis / rtk / mitosis | 1_248441636_T_G |
| 337 | SMC3_1 | 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | other / mitosis / DNArep | 11_65547388_T_G |
| 338 | ARHGAP1_1 | 305_TPCA-1_3 / 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 | other / DNArep / mitosis | 13_113159942_A_G |
| 339 | LPP_1 | 94_TGX221_3 / 1026_Tanespimycin_2 / 1527_Pictilisib_2 | pi3k / other / pi3k | 18_909560_A_G |
| 340 | MGAT1_1 | 300_CX-5461_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 | other / other / mitosis | 13_113159942_A_G |
| 341 | TNFRSF1A_3 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 281_Alectinib_2 | mitosis / rtk / rtk | 13_39724512_C_T / 11_65547388_T_G / 17_55774876_T_G |
| 342 | C12orf10_1 | 1091_BMS-536924_3 / 1054_Palbociclib_2 / 1012_Vorinostat_1 | igfr / cell_cyc / chromatin | 10_73803641_A_G |
| 343 | KLF15_1 | 196_Phenformin_3 / 344_THZ-2-49_3 / 94_TGX221_3 | metabol / cell_cyc / pi3k | 8_7259511_T_C |
| 344 | RSL1D1_1 | 1012_Vorinostat_1 / 333_T0901317_3 / 276_CAY10603_3 | chromatin / other / chromatin | 17_55774876_T_G |
| 345 | CDK2AP2_1 | 226_GSK1070916_2 / 275_I-BET-762_3 / 305_TPCA-1_3 | mitosis / chromatin / other | 13_113159942_A_G |
| 346 | ENOX1_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 / 275_I-BET-762_3 | mitosis / rtk / chromatin | 13_113159942_A_G |
| 347 | KLHL36_1 | 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 / 304_SB52334_3 | apop / mitosis / rtk | 13_113159942_A_G |
| 348 | C1R_1 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 | mitosis / DNArep / rtk | 13_113159942_A_G |
| 349 | DLL3_1 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 304_SB52334_3 | mitosis / DNArep / rtk | 13_113159942_A_G |
| 350 | NPC1_1 | 1012_Vorinostat_1 / 185_Linsitinib_2 / 275_I-BET-762_3 | chromatin / igfr / chromatin | 6_106621398_T_C |
| 351 | BPTF_1 | 179_5-Fluorouracil_1 / 1012_Vorinostat_1 / 305_TPCA-1_3 | DNArep / chromatin / other | 17_55774876_T_G |
| 352 | CCNB1IP1_1 | 1012_Vorinostat_1 / 179_5-Fluorouracil_1 / 305_TPCA-1_3 | chromatin / DNArep / other | 17_55774876_T_G |
| 353 | NPC2_1 | 304_SB52334_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 | rtk / mitosis / other | 13_113159942_A_G |
| 354 | ABAT_3 | 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 | igfr / mitosis / igfr | 16_24930679_T_G / 3_51381020_A_G / 19_18216930_A_C |
| 355 | CEP170_3 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 13_113159942_A_G / 2_218266875_A_C / 11_65547388_T_G |
| 356 | NUCB1_3 | 253_XMD14-99_3 / 294_MPS-1-IN-1_3 | rtk / mitosis | 15_75524142_T_C / 1_26774532_T_C / 19_3281403_A_C |
| 357 | LAMP1_5 | 1012_Vorinostat_1 / 333_T0901317_3 | chromatin / other | 1_108718913_T_G / 5_181155466_T_G / 9_108900415_C_A / 2_154259039_T_G / 7_32543154_A_C |
| 358 | MAP4_2 | 94_TGX221_3 / 1026_Tanespimycin_2 | pi3k / other | 7_72942379_A_C / 8_7290003_A_C |
| 359 | MSH6_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 | mitosis / other | 20_42084724_T_C |
| 360 | NECAP2_5 | 179_5-Fluorouracil_1 / 300_CX-5461_3 | DNArep / other | 1_45019269_T_G / 13_113159942_A_G / 16_1817242_T_C / 17_55774876_T_G / 9_37887606_C_T |
| 361 | RFX7_1 | 275_I-BET-762_3 / 305_TPCA-1_3 | chromatin / other | 15_65451964_A_G |
| 362 | LOXL1_1 | 94_TGX221_3 / 344_THZ-2-49_3 | pi3k / cell_cyc | 7_72942379_A_C |
| 363 | RAB11FIP5_1 | 344_THZ-2-49_3 / 94_TGX221_3 | cell_cyc / pi3k | 7_72942379_A_C |
| 364 | SYNC_1 | 344_THZ-2-49_3 / 94_TGX221_3 | cell_cyc / pi3k | 7_72942379_A_C |
| 365 | MYT1_2 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 17_41725799_T_G / 20_42084724_T_C |
| 366 | CNTNAP2_4 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | mitosis / DNArep | 2_108507561_T_G / 13_113159942_A_G / X_2856636_A_C / 16_55415_T_G |
| 367 | SMARCA5_4 | 305_TPCA-1_3 / 294_MPS-1-IN-1_3 | other / mitosis | 15_65451964_A_G / 17_81086334_C_G / 11_65547388_T_G / 12_40313960_G_T |
| 368 | B3GNT9_4 | 179_5-Fluorouracil_1 / 1011_Navitoclax_2 | DNArep / apop | 15_66561152_T_G / 17_55774876_T_G / 11_65547388_T_G / 7_108023984_G_A |
| 369 | GAL_2 | 1012_Vorinostat_1 / 1091_BMS-536924_3 | chromatin / igfr | 2_66439901_A_C / 9_37887606_C_T |
| 370 | TRIM56_5 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 | DNArep / mitosis | 17_55774876_T_G / 13_113159942_A_G / 20_42084724_T_C / 16_1817242_T_C / 16_30953637_A_C |
| 371 | CRIM1_3 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 | mitosis / chromatin | 12_40313960_G_T / 1_20724406_A_C / 17_44212322_A_G |
| 372 | PNMA3_5 | 294_MPS-1-IN-1_3 / 293_Amuvatinib_2 | mitosis / rtk | 2_113934259_C_T / 16_55415_T_G / 20_16044565_T_G / 22_17727059_T_G / 1_149852603_A_G |
| 373 | HIST3H2A_3 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 | chromatin / mitosis | 10_11921140_T_G / 16_18379704_T_G / 20_16044565_T_G |
| 374 | ATCAY_5 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / erk_mapk | 13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C / 6_33279455_T_G / 9_5549463_A_C |
| 375 | SMARCA4_2 | 1012_Vorinostat_1 / 1011_Navitoclax_2 | chromatin / apop | 11_65547388_T_G / 5_181155466_T_G |
| 376 | LIN28B_2 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 | chromatin / mitosis | 5_181155466_T_G / 2_113934259_C_T |
| 377 | OLFML2A_5 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 | erk_mapk / mitosis | 2_154854926_A_C / 17_7797836_A_C / 6_30705792_T_G / 11_65547388_T_G / 15_84241166_A_C |
| 378 | ACP1_5 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 | mitosis / apop | 19_3281403_A_C / 2_113934259_C_T / 5_181155466_T_G / 2_86604885_C_A / 11_12162199_T_G |
| 379 | ACTL6B_3 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / erk_mapk | 16_1817242_T_C / 13_113159942_A_G / 11_43920052_A_C |
| 380 | PHF21B_4 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 13_113159942_A_G / 16_1817242_T_C / 11_12162199_T_G / 16_30953637_A_C |
| 381 | BAZ1A_1 | 1012_Vorinostat_1 / 275_I-BET-762_3 | chromatin / chromatin | 15_65451964_A_G |
| 382 | TMEM30A_1 | 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 | mitosis / igfr | 12_104287190_A_G |
| 383 | NOL11_2 | 344_THZ-2-49_3 / 94_TGX221_3 | cell_cyc / pi3k | 8_7290003_A_C / 1_1918090_A_G |
| 384 | BEND4_5 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 | chromatin / mitosis | 5_181155466_T_G / 6_37022626_A_C / 2_237368621_T_G / 12_6818898_A_C / 12_51745916_T_G |
| 385 | ELOVL1_3 | 185_Linsitinib_2 / 179_5-Fluorouracil_1 | igfr / DNArep | 13_113159942_A_G / 16_1817242_T_C / 9_37887606_C_T |
| 386 | PFKM_4 | 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 | igfr / mitosis | 13_20031246_A_C / 9_37887606_C_T / 20_16044565_T_G / 10_79312556_A_G |
| 387 | NMNAT1_2 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / erk_mapk | 15_82519765_A_C / 19_3281403_A_C |
| 388 | TIGD1_2 | 1012_Vorinostat_1 / 179_5-Fluorouracil_1 | chromatin / DNArep | 17_55774876_T_G / 1_150261398_T_G |
| 389 | ARL1_5 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 | chromatin / mitosis | 9_93293047_T_G / 13_113159942_A_G / 12_51745916_T_G / 6_25488355_C_T / 6_25510468_CAT_C |
| 390 | CPLX1_4 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 | erk_mapk / mitosis | 16_1817242_T_C / 13_113159942_A_G / 16_30953637_A_C / 18_79527652_GAA_G |
| 391 | PAX6_5 | 1012_Vorinostat_1 / 263_FR-180204_3 | chromatin / erk_mapk | 1_234309145_T_G / 1_156286332_T_G / 1_54243266_A_G / 12_44376791_T_A / 10_50311228_T_G |
| 392 | ANXA2_5 | 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 | apop / mitosis | 12_57178583_A_C / 2_86604885_C_A / 5_181155466_T_G / 6_33296240_C_A / 8_30756677_T_G |
| 393 | BHLHE41_1 | 305_TPCA-1_3 / 185_Linsitinib_2 | other / igfr | 2_113934259_C_T |
| 394 | DPYSL5_2 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 13_113159942_A_G / 2_108507561_T_G |
| 395 | NCL_5 | 1012_Vorinostat_1 / 305_TPCA-1_3 | chromatin / other | 17_55774876_T_G / 19_3281403_A_C / 7_108023984_G_A / 11_65547388_T_G / 13_113159942_A_G |
| 396 | NEK6_3 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 | mitosis / igfr | 11_12162199_T_G / 13_39724512_C_T / 10_50311228_T_G |
| 397 | ADAM11_1 | 253_XMD14-99_3 / 294_MPS-1-IN-1_3 | rtk / mitosis | 9_128964364_CT_C |
| 398 | BMP1_1 | 94_TGX221_3 / 196_Phenformin_3 | pi3k / metabol | 7_72942379_A_C |
| 399 | CRABP1_1 | 344_THZ-2-49_3 / 94_TGX221_3 | cell_cyc / pi3k | 7_72942379_A_C |
| 400 | CREB3_1 | 94_TGX221_3 / 344_THZ-2-49_3 | pi3k / cell_cyc | 7_72942379_A_C |
| 401 | CTSB_1 | 196_Phenformin_3 / 94_TGX221_3 | metabol / pi3k | 7_72942379_A_C |
| 402 | GLB1_1 | 196_Phenformin_3 / 94_TGX221_3 | metabol / pi3k | 7_72942379_A_C |
| 403 | LGALS3_1 | 196_Phenformin_3 / 94_TGX221_3 | metabol / pi3k | 7_72942379_A_C |
| 404 | SMPD1_1 | 94_TGX221_3 / 344_THZ-2-49_3 | pi3k / cell_cyc | 7_72942379_A_C |
| 405 | GTPBP4_1 | 263_FR-180204_3 / 1012_Vorinostat_1 | erk_mapk / chromatin | 12_40313960_G_T |
| 406 | ACTR3B_2 | 294_MPS-1-IN-1_3 / 310_YM201636_3 | mitosis / other | 13_113159942_A_G / 5_170034543_C_T |
| 407 | CSRP1_3 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 10_11921140_T_G / 2_27774175_G_T / 17_55774876_T_G |
| 408 | SEPHS1_1 | 1012_Vorinostat_1 / 305_TPCA-1_3 | chromatin / other | 2_113934259_C_T |
| 409 | ACTN2_1 | 253_XMD14-99_3 / 294_MPS-1-IN-1_3 | rtk / mitosis | 1_213007133_T_G |
| 410 | NMRK1_2 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 | mitosis / chromatin | 12_7433515_G_T / 16_55415_T_G |
| 411 | TFAP2A_1 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 | erk_mapk / mitosis | 3_165019547_G_T |
| 412 | CAV1_3 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 | mitosis / chromatin | 17_81086334_C_G / 13_39724512_C_T / 12_51745916_T_G |
| 413 | PQLC3_2 | 1012_Vorinostat_1 / 179_5-Fluorouracil_1 | chromatin / DNArep | 10_11921140_T_G / 16_18379704_T_G |
| 414 | RPL9_4 | 179_5-Fluorouracil_1 / 305_TPCA-1_3 | DNArep / other | 11_12162199_T_G / 3_165019547_G_T / 11_65547388_T_G / 16_72788732_T_G |
| 415 | H2AFY2_3 | 185_Linsitinib_2 / 294_MPS-1-IN-1_3 | igfr / mitosis | 10_11921140_T_G / 1_213007133_T_G / 11_12162199_T_G |
| 416 | MCM10_1 | 1011_Navitoclax_2 / 1012_Vorinostat_1 | apop / chromatin | 2_170965958_A_C |
| 417 | G6PD_1 | 179_5-Fluorouracil_1 / 300_CX-5461_3 | DNArep / other | 16_87644643_G_A |
| 418 | TADA1_1 | 179_5-Fluorouracil_1 / 1012_Vorinostat_1 | DNArep / chromatin | 10_11921140_T_G |
| 419 | KCNC1_5 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 16_30953637_A_C / 9_5549463_A_C / 17_76472531_A_C / 11_43920052_A_C / 16_1817242_T_C |
| 420 | JPH4_1 | 294_MPS-1-IN-1_3 / 281_Alectinib_2 | mitosis / rtk | 12_40313960_G_T |
| 421 | ZNF121_3 | 263_FR-180204_3 / 179_5-Fluorouracil_1 | erk_mapk / DNArep | 13_113159942_A_G / 16_1817242_T_C / 11_12162199_T_G |
| 422 | TMEM206_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 9_69516199_A_C |
| 423 | HS3ST4_1 | 179_5-Fluorouracil_1 / 300_CX-5461_3 | DNArep / other | 3_128945112_G_A |
| 424 | MRPL48_1 | 1264_SGC0946_3 / 1012_Vorinostat_1 | chromatin / chromatin | 5_181155466_T_G |
| 425 | PPAT_5 | 294_MPS-1-IN-1_3 / 1012_Vorinostat_1 | mitosis / chromatin | 8_27431326_A_G / 1_228244520_T_G / 6_56557393_C_T / 1_46261223_G_A / 1_234373536_T_G |
| 426 | CELF3_3 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 3_128908109_T_C / 16_1817242_T_C / 3_128945112_G_A |
| 427 | ABCC8_1 | 294_MPS-1-IN-1_3 / 281_Alectinib_2 | mitosis / rtk | 3_128945112_G_A |
| 428 | KIF1C_4 | 304_SB52334_3 / 294_MPS-1-IN-1_3 | rtk / mitosis | 13_113159942_A_G / 19_43359207_C_A / 16_1817242_T_C / 9_93293047_T_G |
| 429 | MOSPD2_1 | 263_FR-180204_3 / 1012_Vorinostat_1 | erk_mapk / chromatin | 11_12162199_T_G |
| 430 | ANKRD46_1 | 304_SB52334_3 / 294_MPS-1-IN-1_3 | rtk / mitosis | 10_11921140_T_G |
| 431 | RSL24D1_1 | 1012_Vorinostat_1 / 1091_BMS-536924_3 | chromatin / igfr | 9_69516199_A_C |
| 432 | HNRNPC_1 | 94_TGX221_3 / 196_Phenformin_3 | pi3k / metabol | 8_7290003_A_C |
| 433 | LYST_1 | 196_Phenformin_3 / 94_TGX221_3 | metabol / pi3k | 8_7290003_A_C |
| 434 | MRPS31_2 | 304_SB52334_3 / 1012_Vorinostat_1 | rtk / chromatin | 1_112520503_A_G / 11_65547388_T_G |
| 435 | ANXA11_1 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 | DNArep / mitosis | 16_1817242_T_C |
| 436 | GABRB3_2 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | mitosis / DNArep | 13_113159942_A_G / 16_1817242_T_C |
| 437 | ITGB5_4 | 179_5-Fluorouracil_1 / 1012_Vorinostat_1 | DNArep / chromatin | 2_154854926_A_C / 1_234373536_T_G / 11_65547388_T_G / 17_55774876_T_G |
| 438 | TAGLN_5 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 2_157299566_T_G / 22_18345007_A_C / 1_54243266_A_G / 1_156286332_T_G / X_49565582_A_C |
| 439 | KLF6_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 | mitosis / other | 12_95474188_T_G |
| 440 | GLIS3_1 | 344_THZ-2-49_3 / 196_Phenformin_3 | cell_cyc / metabol | 8_7290003_A_C |
| 441 | GRPEL2_3 | 1012_Vorinostat_1 / 179_5-Fluorouracil_1 | chromatin / DNArep | 9_108900415_C_A / 5_133233474_T_G / 10_11921140_T_G |
| 442 | SORCS1_2 | 294_MPS-1-IN-1_3 / 281_Alectinib_2 | mitosis / rtk | 16_259458_T_G / 13_113159942_A_G |
| 443 | TAF3_1 | 344_THZ-2-49_3 / 94_TGX221_3 | cell_cyc / pi3k | 15_75876091_T_G |
| 444 | ZNF638_4 | 304_SB52334_3 / 269_NSC-207895_3 | rtk / p53 | 10_73803531_T_C / 13_39724512_C_T / 22_17727059_T_G / 5_427675_T_C |
| 445 | RPAIN_2 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 9_69516199_A_C / 11_18089364_C_A |
| 446 | PRMT6_2 | 275_I-BET-762_3 / 305_TPCA-1_3 | chromatin / other | 7_35240878_C_T / 3_53872486_G_A |
| 447 | CERCAM_1 | 1012_Vorinostat_1 / 305_TPCA-1_3 | chromatin / other | 6_30705792_T_G |
| 448 | TWSG1_1 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 | chromatin / mitosis | 12_51745916_T_G |
| 449 | NAP1L1_1 | 305_TPCA-1_3 / 272_AR-42_2 | other / chromatin | 7_2269556_T_A |
| 450 | NQO2_1 | 179_5-Fluorouracil_1 / 294_MPS-1-IN-1_3 | DNArep / mitosis | 10_79312556_A_G |
| 451 | EXOSC5_1 | 1012_Vorinostat_1 / 179_5-Fluorouracil_1 | chromatin / DNArep | 7_108023984_G_A |
| 452 | LTBP2_1 | 196_Phenformin_3 / 344_THZ-2-49_3 | metabol / cell_cyc | 11_68780792_C_A |
| 453 | KIAA1549_3 | 304_SB52334_3 / 294_MPS-1-IN-1_3 | rtk / mitosis | 17_75834935_G_A / 15_40855887_C_T / 15_40855965_C_T |
| 454 | LRP10_2 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 11_65547388_T_G / 17_55774876_T_G |
| 455 | CIB1_4 | 185_Linsitinib_2 / 1012_Vorinostat_1 | igfr / chromatin | 13_113159942_A_G / 1_150261398_T_G / 16_1817242_T_C / 1_149852603_A_G |
| 456 | RPL19_1 | 1012_Vorinostat_1 / 226_GSK1070916_2 | chromatin / mitosis | 2_61492168_C_A |
| 457 | CBX2_2 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 | chromatin / mitosis | 10_73803641_A_G / 17_80352778_T_G |
| 458 | CLVS2_2 | 1091_BMS-536924_3 / 294_MPS-1-IN-1_3 | igfr / mitosis | 2_108507561_T_G / 11_65547388_T_G |
| 459 | GLIPR1_2 | 1012_Vorinostat_1 / 179_5-Fluorouracil_1 | chromatin / DNArep | 19_4911043_A_C / 10_11921140_T_G |
| 460 | TAPBP_3 | 294_MPS-1-IN-1_3 / 275_I-BET-762_3 | mitosis / chromatin | 11_12162199_T_G / 16_30953637_A_C / 12_40313960_G_T |
| 461 | GNA12_3 | 179_5-Fluorouracil_1 / 300_CX-5461_3 | DNArep / other | 13_113325626_T_C / 7_129389033_T_G / 12_51745916_T_G |
| 462 | MBNL1_1 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | mitosis / DNArep | 9_69516199_A_C |
| 463 | ISYNA1_2 | 344_THZ-2-49_3 / 156_AZD6482_2 | cell_cyc / pi3k | 15_43716974_A_C / 3_197683305_A_C |
| 464 | PRLHR_2 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / erk_mapk | 10_26746549_C_T / 6_56067480_C_T |
| 465 | IQGAP1_5 | 1091_BMS-536924_3 / 1012_Vorinostat_1 | igfr / chromatin | 8_122952205_T_G / 3_128945112_G_A / 13_113325635_A_G / 19_9566733_T_G / 5_181155466_T_G |
| 466 | SDC4_2 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | mitosis / DNArep | 12_40313960_G_T / 13_113159942_A_G |
| 467 | NAA25_1 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 | chromatin / mitosis | 7_108023984_G_A |
| 468 | PLEKHA4_1 | 294_MPS-1-IN-1_3 / 226_GSK1070916_2 | mitosis / mitosis | 7_2269556_T_A |
| 469 | TUBA4A_2 | 1012_Vorinostat_1 / 1091_BMS-536924_3 | chromatin / igfr | 7_159142364_T_G / 11_65547388_T_G |
| 470 | SLC35D1_1 | 293_Amuvatinib_2 / 1012_Vorinostat_1 | rtk / chromatin | 16_18379704_T_G |
| 471 | SH3GLB1_1 | 1012_Vorinostat_1 / 1011_Navitoclax_2 | chromatin / apop | 20_42084724_T_C |
| 472 | RPL37_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 | mitosis / other | 11_12162199_T_G |
| 473 | KDELR3_3 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 | cell_cyc / other | 16_72119226_C_G / 16_72129067_G_T / 16_72164743_G_A |
| 474 | DDX60L_1 | 1011_Navitoclax_2 / 179_5-Fluorouracil_1 | apop / DNArep | 11_12162199_T_G |
| 475 | GNPDA2_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 | cell_cyc / other | 3_191358113_C_T |
| 476 | DPY30_1 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / erk_mapk | 14_23276467_A_G |
| 477 | MURC_2 | 1011_Navitoclax_2 / 294_MPS-1-IN-1_3 | apop / mitosis | 17_73203001_T_G / 8_61583890_T_A |
| 478 | CCDC80_2 | 344_THZ-2-49_3 / 94_TGX221_3 | cell_cyc / pi3k | 16_72119226_C_G / 16_72129067_G_T |
| 479 | C12orf23_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 | cell_cyc / other | 16_72119226_C_G |
| 480 | LOX_1 | 344_THZ-2-49_3 / 94_TGX221_3 | cell_cyc / pi3k | 16_72119226_C_G |
| 481 | CEP68_3 | 185_Linsitinib_2 / 304_SB52334_3 | igfr / rtk | 13_113159942_A_G / 8_12430448_C_T / 17_55774876_T_G |
| 482 | BEND3_1 | 196_Phenformin_3 / 344_THZ-2-49_3 | metabol / cell_cyc | 15_75876091_T_G |
| 483 | RPRD2_3 | 156_AZD6482_2 / 344_THZ-2-49_3 | pi3k / cell_cyc | 1_146975626_G_A / 1_146969331_G_A / 1_148117837_C_T |
| 484 | ELAVL4_3 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 13_113159942_A_G / 7_108023984_G_A / 7_108024001_C_T |
| 485 | TRIM21_1 | 294_MPS-1-IN-1_3 / 253_XMD14-99_3 | mitosis / rtk | 1_237687398_C_T |
| 486 | PRPF40B_1 | 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 | mitosis / igfr | 17_64146068_T_G |
| 487 | DCLRE1A_1 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / erk_mapk | 1_219979389_T_A |
| 488 | DUSP12_1 | 1012_Vorinostat_1 / 304_SB52334_3 | chromatin / rtk | 15_75524142_T_C |
| 489 | TFPI_2 | 294_MPS-1-IN-1_3 / 1011_Navitoclax_2 | mitosis / apop | 1_213007133_T_G / 16_1817242_T_C |
| 490 | MYO1C_2 | 1011_Navitoclax_2 / 304_SB52334_3 | apop / rtk | 11_65547388_T_G / 13_113159942_A_G |
| 491 | SYDE1_1 | 94_TGX221_3 / 344_THZ-2-49_3 | pi3k / cell_cyc | 18_41955194_A_G |
| 492 | RANBP1_1 | 1012_Vorinostat_1 / 288_WHI-P97_3 | chromatin / other | 6_30705792_T_G |
| 493 | PRAME_3 | 179_5-Fluorouracil_1 / 1009_Tretinoin_1 | DNArep / other | 16_67909562_C_A / 22_42212334_A_C / 19_57720377_A_G |
| 494 | PNN_1 | 305_TPCA-1_3 / 179_5-Fluorouracil_1 | other / DNArep | 13_39724512_C_T |
| 495 | PHF11_3 | 300_CX-5461_3 / 305_TPCA-1_3 | other / other | 11_12162199_T_G / X_2856636_A_C / X_119150617_A_C |
| 496 | WDR35_1 | 185_Linsitinib_2 / 294_MPS-1-IN-1_3 | igfr / mitosis | 12_109800676_G_A |
| 497 | KCNN4_5 | 1091_BMS-536924_3 / 1012_Vorinostat_1 | igfr / chromatin | 5_181155466_T_G / 20_45938939_T_G / 10_11921140_T_G / 1_15381304_A_C / 10_50311228_T_G |
| 498 | SERPINB6_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 | cell_cyc / other | 2_227062473_GT_G |
| 499 | ACOT9_5 | 294_MPS-1-IN-1_3 / 1091_BMS-536924_3 | mitosis / igfr | 10_11921140_T_G / 11_12162199_T_G / 3_128945112_G_A / 13_113159942_A_G / 6_29631350_A_G |
| 500 | LAMP1_2 | 344_THZ-2-49_3 / 196_Phenformin_3 | cell_cyc / metabol | 1_99728613_A_C / 7_72942379_A_C |
| 501 | C19orf10_2 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 | cell_cyc / other | 16_72129067_G_T / 16_72119226_C_G |
| 502 | EHD2_1 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | mitosis / DNArep | 6_10410133_T_G |
| 503 | DPH5_1 | 1012_Vorinostat_1 / 1054_Palbociclib_2 | chromatin / cell_cyc | 8_12430448_C_T |
| 504 | TMEM169_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 1_112520503_A_G |
| 505 | SMARCB1_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 | cell_cyc / other | 3_197683305_A_C |
| 506 | PLEKHF2_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 7_108023984_G_A |
| 507 | HSF2_5 | 179_5-Fluorouracil_1 / 1011_Navitoclax_2 | DNArep / apop | 11_65547388_T_G / 2_178663651_C_T / 1_234373536_T_G / 16_67878678_T_G / 2_178689190_G_A |
| 508 | ASPH_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 | cell_cyc / other | 2_105307612_A_C |
| 509 | SERINC3_1 | 344_THZ-2-49_3 / 196_Phenformin_3 | cell_cyc / metabol | 2_105307612_A_C |
| 510 | THOC5_1 | 196_Phenformin_3 / 344_THZ-2-49_3 | metabol / cell_cyc | 3_197683305_A_C |
| 511 | SLC6A15_1 | 253_XMD14-99_3 / 294_MPS-1-IN-1_3 | rtk / mitosis | 17_55774876_T_G |
| 512 | TBC1D2_1 | 1012_Vorinostat_1 / 305_TPCA-1_3 | chromatin / other | 1_185150475_G_A |
| 513 | HSPG2_1 | 344_THZ-2-49_3 / 51_Dasatinib_1 | cell_cyc / abl | 1_37703244_A_C |
| 514 | CACNA2D2_1 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 | mitosis / igfr | 17_76472531_A_C |
| 515 | SLC5A6_2 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 | chromatin / mitosis | 7_108023984_G_A / 14_22844242_T_G |
| 516 | DAZAP1_2 | 1012_Vorinostat_1 / 294_MPS-1-IN-1_3 | chromatin / mitosis | 6_73622013_G_C / 6_73635330_C_T |
| 517 | NFIX_2 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | mitosis / DNArep | 10_101004037_A_C / 12_109800676_G_A |
| 518 | ELAVL3_3 | 196_Phenformin_3 / 344_THZ-2-49_3 | metabol / cell_cyc | 2_15474280_T_C / 2_15475786_A_G / 2_15467718_T_C |
| 519 | COPB2_1 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 | cell_cyc / other | 19_16503339_T_G |
| 520 | ZNF219_1 | 1026_Tanespimycin_2 / 156_AZD6482_2 | other / pi3k | 15_43716974_A_C |
| 521 | RNF165_2 | 294_MPS-1-IN-1_3 / 281_Alectinib_2 | mitosis / rtk | 10_11921140_T_G / 16_1817242_T_C |
| 522 | P4HA1_1 | 1011_Navitoclax_2 / 281_Alectinib_2 | apop / rtk | 16_58525116_G_T |
| 523 | CIB2_3 | 344_THZ-2-49_3 / 1026_Tanespimycin_2 | cell_cyc / other | 11_33583339_C_T / 11_33583414_C_T / 11_33606557_T_G |
| 524 | LMAN2_1 | 305_TPCA-1_3 / 294_MPS-1-IN-1_3 | other / mitosis | 11_65547388_T_G |
| 525 | POFUT1_1 | 1026_Tanespimycin_2 / 104_Bortezomib_1 | other / other | 4_118640836_A_T |
| 526 | ITGB1_1 | 94_TGX221_3 / 344_THZ-2-49_3 | pi3k / cell_cyc | 20_46216899_A_C |
| 527 | GFPT2_2 | 156_AZD6482_2 / 94_TGX221_3 | pi3k / pi3k | 7_72942379_A_C / 1_12938859_G_A |
| 528 | SNTB2_2 | 1026_Tanespimycin_2 / 94_TGX221_3 | other / pi3k | 5_36985201_A_G / 5_37000972_A_G |
| 529 | FAM126A_1 | 304_SB52334_3 / 294_MPS-1-IN-1_3 | rtk / mitosis | 1_451649_A_AG |
| 530 | FAM214B_1 | 1012_Vorinostat_1 / 345_KIN001-270_3 | chromatin / cell_cyc | 20_24959779_A_C |
| 531 | E2F5_1 | 1012_Vorinostat_1 / 221_TAK-715_2 | chromatin / jnk_p38 | 19_16896123_T_G |
| 532 | CRMP1_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 13_113159942_A_G |
| 533 | DTX3L_1 | 304_SB52334_3 / 294_MPS-1-IN-1_3 | rtk / mitosis | 13_113159942_A_G |
| 534 | ELAVL3_1 | 304_SB52334_3 / 294_MPS-1-IN-1_3 | rtk / mitosis | 13_113159942_A_G |
| 535 | GATA2_1 | 294_MPS-1-IN-1_3 / 185_Linsitinib_2 | mitosis / igfr | 13_113159942_A_G |
| 536 | GNG4_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 13_113159942_A_G |
| 537 | GPX8_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 13_113159942_A_G |
| 538 | LATS2_1 | 294_MPS-1-IN-1_3 / 304_SB52334_3 | mitosis / rtk | 13_113159942_A_G |
| 539 | TMEM87B_1 | 1011_Navitoclax_2 / 304_SB52334_3 | apop / rtk | 1_237687398_C_T |
| 540 | NR2C1_1 | 305_TPCA-1_3 / 1091_BMS-536924_3 | other / igfr | 9_88647472_G_A |
| 541 | CHMP4B_1 | 333_T0901317_3 / 1012_Vorinostat_1 | other / chromatin | 16_66912991_CGT_C |
| 542 | HPDL_1 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 | mitosis / DNArep | 6_41770599_T_G |
| 543 | HNRPDL_1 | 1012_Vorinostat_1 / 1011_Navitoclax_2 | chromatin / apop | 17_55774876_T_G |
| 544 | MICB_1 | 275_I-BET-762_3 / 304_SB52334_3 | chromatin / rtk | 17_81086334_C_G |
| 545 | C17orf53_5 | 1526_Refametinib_3 / 1498_Selumetinib_2 | erk_mapk / erk_mapk | 3_128481377_A_C / 7_142940415_T_G / 17_74777339_T_G / X_24788994_C_T / 19_39885857_T_G |
| 546 | WDR3_1 | 276_CAY10603_3 / 1012_Vorinostat_1 | chromatin / chromatin | 5_88722571_GA_G |
| 547 | FKBP15_1 | 196_Phenformin_3 / 344_THZ-2-49_3 | metabol / cell_cyc | 2_200493236_A_C |
| 548 | SLC22A23_1 | 94_TGX221_3 | pi3k | 7_72942379_A_C |
| 549 | ST6GALNAC3_1 | 344_THZ-2-49_3 | cell_cyc | 7_72942379_A_C |
| 550 | RCAN1_3 | 1012_Vorinostat_1 | chromatin | 11_65547388_T_G / 2_66439901_A_C / 7_159142364_T_G |
| 551 | CCDC107_2 | 94_TGX221_3 | pi3k | 7_72942379_A_C / 20_62661184_C_T |
| 552 | PAX6_2 | 94_TGX221_3 | pi3k | 7_72942379_A_C / 7_5227302_G_C |
| 553 | IGSF9_5 | 1012_Vorinostat_1 | chromatin | 16_87644643_G_A / 5_181155466_T_G / 13_113325635_A_G / 12_6818898_A_C / 11_12162199_T_G |
| 554 | TFAP4_2 | 1012_Vorinostat_1 | chromatin | 5_181155466_T_G / 11_65547388_T_G |
| 555 | B2M_5 | 294_MPS-1-IN-1_3 | mitosis | 11_12162199_T_G / 12_6818898_A_C / 20_42084724_T_C / 1_108718913_T_G / 3_128945112_G_A |
| 556 | ZCCHC12_1 | 1166_QL-VIII-58_3 | tor | 1_1676790_C_T |
| 557 | MYL12B_3 | 294_MPS-1-IN-1_3 | mitosis | 2_108507561_T_G / X_38285780_G_A / 1_237687398_C_T |
| 558 | SHPRH_5 | 179_5-Fluorouracil_1 | DNArep | 11_65547388_T_G / 17_55774876_T_G / 2_108507561_T_G / 22_42212334_A_C / 13_113159942_A_G |
| 559 | NRSN1_4 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G / 16_30953637_A_C / 16_1817242_T_C / 9_93293047_T_G |
| 560 | HNRNPR_3 | 288_WHI-P97_3 | other | 17_40348252_T_G / 10_101004037_A_C / 17_73203001_T_G |
| 561 | RRAGC_2 | 263_FR-180204_3 | erk_mapk | 9_37887606_C_T / 10_79312556_A_G |
| 562 | CTSA_3 | 1012_Vorinostat_1 | chromatin | 11_12162199_T_G / 5_181155466_T_G / 16_87644643_G_A |
| 563 | DUSP26_3 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G / 15_43578884_A_G / 16_1817242_T_C |
| 564 | IFI35_2 | 294_MPS-1-IN-1_3 | mitosis | 11_12162199_T_G / 16_30953637_A_C |
| 565 | FAM163A_4 | 294_MPS-1-IN-1_3 | mitosis | 16_30953637_A_C / 6_33279455_T_G / 20_16044565_T_G / 2_113934259_C_T |
| 566 | DHX15_3 | 294_MPS-1-IN-1_3 | mitosis | 1_26774532_T_C / 19_3281403_A_C / 11_12162199_T_G |
| 567 | WDR86_3 | 305_TPCA-1_3 | other | 16_87644643_G_A / 20_42084724_T_C / 19_9566733_T_G |
| 568 | CECR5_1 | 1012_Vorinostat_1 | chromatin | 5_181155466_T_G |
| 569 | VASH2_1 | 1012_Vorinostat_1 | chromatin | 5_181155466_T_G |
| 570 | KCNH8_2 | 294_MPS-1-IN-1_3 | mitosis | 3_100302035_G_T / 2_169735166_A_C |
| 571 | MRPS25_3 | 179_5-Fluorouracil_1 | DNArep | 15_75524142_T_C / 9_37887606_C_T / 1_213007133_T_G |
| 572 | COPS7B_4 | 1012_Vorinostat_1 | chromatin | 10_11921140_T_G / 19_3281403_A_C / 1_150261398_T_G / 10_97048952_T_G |
| 573 | PHYHIPL_2 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G / 16_30953637_A_C |
| 574 | ATP6V0E1_3 | 294_MPS-1-IN-1_3 | mitosis | 12_40313960_G_T / 11_12162199_T_G / 15_43211582_A_C |
| 575 | CEP44_5 | 294_MPS-1-IN-1_3 | mitosis | 11_12162199_T_G / 10_11921140_T_G / 17_55774876_T_G / 11_65547388_T_G / 10_27223356_T_C |
| 576 | SEC22C_1 | 305_TPCA-1_3 | other | 15_65451964_A_G |
| 577 | TRIM38_2 | 294_MPS-1-IN-1_3 | mitosis | 15_43578884_A_G / 17_51169925_C_T |
| 578 | MTF2_1 | 1026_Tanespimycin_2 | other | 7_72942379_A_C |
| 579 | ZC3H15_4 | 263_FR-180204_3 | erk_mapk | 2_154854926_A_C / 7_149253814_T_G / 20_63929447_G_C / 3_196782572_G_T |
| 580 | THOC5_2 | 1012_Vorinostat_1 | chromatin | 1_54243266_A_G / 22_22098988_G_T |
| 581 | CLASP2_2 | 185_Linsitinib_2 | igfr | 9_37887606_C_T / 16_1817242_T_C |
| 582 | SLC18A2_2 | 294_MPS-1-IN-1_3 | mitosis | 16_30953637_A_C / 10_101004037_A_C |
| 583 | NDUFAF4_4 | 1012_Vorinostat_1 | chromatin | 11_65547388_T_G / 1_234373536_T_G / 15_65451964_A_G / 15_75524142_T_C |
| 584 | CHD4_1 | 1012_Vorinostat_1 | chromatin | 12_51745916_T_G |
| 585 | KIF5A_3 | 294_MPS-1-IN-1_3 | mitosis | 16_1817242_T_C / 11_12162199_T_G / 1_20724406_A_C |
| 586 | CNN2_2 | 294_MPS-1-IN-1_3 | mitosis | 11_12162199_T_G / 11_94082585_T_C |
| 587 | DCBLD1_2 | 294_MPS-1-IN-1_3 | mitosis | 10_26746549_C_T / 11_12162199_T_G |
| 588 | SPSB4_2 | 304_SB52334_3 | rtk | 15_55340661_G_T / 15_55329691_T_C |
| 589 | EDIL3_1 | 263_FR-180204_3 | erk_mapk | 11_12162199_T_G |
| 590 | GALNT10_3 | 294_MPS-1-IN-1_3 | mitosis | 6_30705792_T_G / 11_65547388_T_G / 12_40313960_G_T |
| 591 | H1FX_1 | 294_MPS-1-IN-1_3 | mitosis | 11_73355795_A_G |
| 592 | OSGIN1_4 | 275_I-BET-762_3 | chromatin | 4_61579528_T_C / 3_53871281_T_C / 3_53872486_G_A / 3_53888593_A_G |
| 593 | PRRX1_1 | 94_TGX221_3 | pi3k | 10_96527504_G_C |
| 594 | SERF2_1 | 1012_Vorinostat_1 | chromatin | 12_52013974_A_C |
| 595 | PPP1CC_3 | 1012_Vorinostat_1 | chromatin | 10_11921140_T_G / 1_185150475_G_A / 11_124896232_A_G |
| 596 | SYDE1_2 | 179_5-Fluorouracil_1 | DNArep | 11_65547388_T_G / 13_113159942_A_G |
| 597 | C11orf74_2 | 294_MPS-1-IN-1_3 | mitosis | 12_124473081_C_T / 19_17205202_T_G |
| 598 | NEFH_1 | 294_MPS-1-IN-1_3 | mitosis | 16_55415_T_G |
| 599 | MPPE1_2 | 294_MPS-1-IN-1_3 | mitosis | 1_160801918_G_C / 6_10410133_T_G |
| 600 | RAC3_1 | 281_Alectinib_2 | rtk | 20_42084724_T_C |
| 601 | XRCC2_1 | 1011_Navitoclax_2 | apop | 2_219297298_T_G |
| 602 | PVRL2_2 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G / 11_12162199_T_G |
| 603 | JAKMIP1_3 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G / 16_1817242_T_C / 6_33279455_T_G |
| 604 | RETSAT_2 | 305_TPCA-1_3 | other | 1_113900413_C_G / 10_43200831_A_G |
| 605 | ECSIT_4 | 1012_Vorinostat_1 | chromatin | 19_4911043_A_C / 2_60761746_T_G / 11_43920052_A_C / 12_6818898_A_C |
| 606 | KCTD11_5 | 263_FR-180204_3 | erk_mapk | 11_65547388_T_G / 14_93183653_A_C / 13_113159942_A_G / 1_54243266_A_G / 17_7797836_A_C |
| 607 | NOL4_1 | 294_MPS-1-IN-1_3 | mitosis | 16_30953637_A_C |
| 608 | PHACTR3_1 | 294_MPS-1-IN-1_3 | mitosis | 16_30953637_A_C |
| 609 | RTN1_1 | 294_MPS-1-IN-1_3 | mitosis | 16_30953637_A_C |
| 610 | STMN2_1 | 294_MPS-1-IN-1_3 | mitosis | 16_30953637_A_C |
| 611 | AP2S1_2 | 304_SB52334_3 | rtk | 2_61492168_C_A / 2_27774175_G_T |
| 612 | ZFYVE21_1 | 179_5-Fluorouracil_1 | DNArep | 22_42212334_A_C |
| 613 | UNC13A_1 | 1026_Tanespimycin_2 | other | 2_105307612_A_C |
| 614 | HRH3_2 | 294_MPS-1-IN-1_3 | mitosis | 3_128945112_G_A / 6_33279455_T_G |
| 615 | SLC46A3_1 | 275_I-BET-762_3 | chromatin | 11_12162199_T_G |
| 616 | FANCF_1 | 226_GSK1070916_2 | mitosis | 2_61492168_C_A |
| 617 | NUP188_1 | 1011_Navitoclax_2 | apop | 17_73203001_T_G |
| 618 | RASL11B_4 | 294_MPS-1-IN-1_3 | mitosis | 5_181155466_T_G / 11_73355795_A_G / 1_220067324_T_G / 9_126483890_T_G |
| 619 | RPL35A_1 | 253_XMD14-99_3 | rtk | 1_145961089_T_G |
| 620 | MRPS34_2 | 263_FR-180204_3 | erk_mapk | 6_32035203_A_C / 22_22098988_G_T |
| 621 | GIMAP2_3 | 179_5-Fluorouracil_1 | DNArep | 1_155709773_T_G / 16_87644643_G_A / 12_51745916_T_G |
| 622 | CEP290_2 | 305_TPCA-1_3 | other | 15_65451964_A_G / 12_57062993_T_G |
| 623 | GLTPD1_2 | 300_CX-5461_3 | other | 1_44339331_A_G / 9_37887606_C_T |
| 624 | GPHN_2 | 294_MPS-1-IN-1_3 | mitosis | 11_12162199_T_G / 13_39724512_C_T |
| 625 | CASP1_1 | 294_MPS-1-IN-1_3 | mitosis | 12_40313960_G_T |
| 626 | ZNF696_1 | 294_MPS-1-IN-1_3 | mitosis | 12_40313960_G_T |
| 627 | PUM2_1 | 294_MPS-1-IN-1_3 | mitosis | 19_3281403_A_C |
| 628 | MEIS1_3 | 179_5-Fluorouracil_1 | DNArep | 13_113159942_A_G / 17_36608462_A_C / 16_29836801_T_G |
| 629 | IFI30_1 | 269_NSC-207895_3 | p53 | 16_55415_T_G |
| 630 | IL11RA_1 | 1012_Vorinostat_1 | chromatin | 10_11921140_T_G |
| 631 | NUCB2_1 | 1012_Vorinostat_1 | chromatin | 10_11921140_T_G |
| 632 | PTP4A3_1 | 1012_Vorinostat_1 | chromatin | 10_11921140_T_G |
| 633 | ADRBK2_2 | 294_MPS-1-IN-1_3 | mitosis | 11_65547388_T_G / 17_78476773_C_T |
| 634 | PKIG_3 | 156_AZD6482_2 | pi3k | 10_47523038_G_A / 10_46337735_A_G / 2_105307612_A_C |
| 635 | SET_2 | 1011_Navitoclax_2 | apop | 2_113934259_C_T / 7_44964464_T_C |
| 636 | FLII_4 | 294_MPS-1-IN-1_3 | mitosis | 12_51745916_T_G / 1_213007133_T_G / 16_1342948_A_C / 2_86027990_C_A |
| 637 | ARF6_1 | 300_CX-5461_3 | other | 1_173850301_T_G |
| 638 | HMGCR_1 | 294_MPS-1-IN-1_3 | mitosis | 16_1817242_T_C |
| 639 | ST8SIA3_1 | 294_MPS-1-IN-1_3 | mitosis | 16_1817242_T_C |
| 640 | UNC80_1 | 294_MPS-1-IN-1_3 | mitosis | 16_1817242_T_C |
| 641 | CCT8_3 | 1012_Vorinostat_1 | chromatin | 7_108024001_C_T / 8_61583890_T_A / 7_108023984_G_A |
| 642 | TRIM28_1 | 1012_Vorinostat_1 | chromatin | 19_40695973_T_G |
| 643 | CDC25A_2 | 1011_Navitoclax_2 | apop | 19_9566733_T_G / 14_55169342_TAAA_T |
| 644 | GLTP_2 | 1012_Vorinostat_1 | chromatin | 2_61492168_C_A / 1_149852603_A_G |
| 645 | CCDC77_1 | 1012_Vorinostat_1 | chromatin | 7_108023984_G_A |
| 646 | MCF2L_1 | 1091_BMS-536924_3 | igfr | 15_43578884_A_G |
| 647 | SLC6A2_2 | 294_MPS-1-IN-1_3 | mitosis | 16_1817242_T_C / 13_113159942_A_G |
| 648 | SYP_2 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G / 16_1817242_T_C |
| 649 | CNOT6_1 | 1012_Vorinostat_1 | chromatin | 15_75524142_T_C |
| 650 | VARS_1 | 1012_Vorinostat_1 | chromatin | 15_75524142_T_C |
| 651 | IFITM3_4 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G / 16_1817242_T_C / 7_149253814_T_G / 8_27431326_A_G |
| 652 | PEX5_1 | 1091_BMS-536924_3 | igfr | 2_96842345_G_C |
| 653 | SLC31A2_2 | 196_Phenformin_3 | metabol | 2_171833908_C_T / 2_171744206_C_A |
| 654 | GRIK3_1 | 294_MPS-1-IN-1_3 | mitosis | 3_128945112_G_A |
| 655 | VN1R1_1 | 294_MPS-1-IN-1_3 | mitosis | 1_213007133_T_G |
| 656 | TFB2M_1 | 1012_Vorinostat_1 | chromatin | 6_32002466_A_C |
| 657 | MAD2L1_1 | 1011_Navitoclax_2 | apop | 19_9566733_T_G |
| 658 | MCM7_1 | 1011_Navitoclax_2 | apop | 19_9566733_T_G |
| 659 | MLF1IP_1 | 1011_Navitoclax_2 | apop | 19_9566733_T_G |
| 660 | RFC3_1 | 1011_Navitoclax_2 | apop | 19_9566733_T_G |
| 661 | RPL13A_5 | 1012_Vorinostat_1 | chromatin | 4_145127510_C_T / 12_57470756_A_G / 15_45095024_A_C / 19_44985182_T_G / 20_47227145_T_G |
| 662 | LINGO2_5 | 221_TAK-715_2 | jnk_p38 | 12_51745916_T_G / 17_737856_G_T / 10_74988957_T_G / 3_113344632_A_C / 4_173528913_A_G |
| 663 | DNAJC22_1 | 1011_Navitoclax_2 | apop | 15_75268724_T_G |
| 664 | LAPTM4B_5 | 1012_Vorinostat_1 | chromatin | 13_19425701_C_A / 7_117129719_T_G / 2_131597280_C_G / 1_54243276_T_G / 20_34850996_A_C |
| 665 | MRPL21_1 | 1012_Vorinostat_1 | chromatin | 22_22098988_G_T |
| 666 | KBTBD6_5 | 304_SB52334_3 | rtk | 11_65547388_T_G / 5_141478412_T_C / 13_113159942_A_G / 2_108507561_T_G / 6_30705792_T_G |
| 667 | ENDOD1_1 | 1012_Vorinostat_1 | chromatin | 5_80744593_A_C |
| 668 | DYNLT3_1 | 1012_Vorinostat_1 | chromatin | 16_70661204_T_G |
| 669 | FBXO33_3 | 253_XMD14-99_3 | rtk | 6_25488355_C_T / 6_25510468_CAT_C / 4_144114635_G_A |
| 670 | MAGT1_3 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G / 6_29631350_A_G / 10_11921140_T_G |
| 671 | RAP2C_1 | 253_XMD14-99_3 | rtk | 19_4911043_A_C |
| 672 | UNC13A_4 | 294_MPS-1-IN-1_3 | mitosis | 6_37282313_A_C / 16_1817242_T_C / 10_11921140_T_G / 13_113159942_A_G |
| 673 | MFAP5_1 | 150_Bicalutamide_1 | other | 9_18775833_A_C |
| 674 | CUX2_2 | 294_MPS-1-IN-1_3 | mitosis | 11_12162199_T_G / 8_122952205_T_G |
| 675 | MED25_5 | 1012_Vorinostat_1 | chromatin | 17_18282776_T_G / 11_74492398_A_C / 19_1460944_T_G / 1_224418353_A_C / X_54813054_T_G |
| 676 | MYT1L_2 | 294_MPS-1-IN-1_3 | mitosis | 16_1817242_T_C / 15_43211582_A_C |
| 677 | TMEM18_2 | 176_IPA-3_3 | cytoskeleton | 2_54968084_G_A / 2_55027029_T_A |
| 678 | CCT7_1 | 1012_Vorinostat_1 | chromatin | 12_40313960_G_T |
| 679 | MAK16_1 | 1012_Vorinostat_1 | chromatin | 12_40313960_G_T |
| 680 | MRPS21_1 | 1012_Vorinostat_1 | chromatin | 12_40313960_G_T |
| 681 | POLR1B_1 | 1012_Vorinostat_1 | chromatin | 12_40313960_G_T |
| 682 | GTPBP1_2 | 333_T0901317_3 | other | 9_37887606_C_T / 11_43920052_A_C |
| 683 | EBF3_1 | 294_MPS-1-IN-1_3 | mitosis | 9_5549463_A_C |
| 684 | MTUS1_2 | 1012_Vorinostat_1 | chromatin | 19_53998273_G_A / 19_53999532_G_A |
| 685 | NUP133_2 | 179_5-Fluorouracil_1 | DNArep | 10_11921140_T_G / 11_12162199_T_G |
| 686 | CTNND1_2 | 294_MPS-1-IN-1_3 | mitosis | 6_30705800_T_G / 9_69516199_A_C |
| 687 | NDUFB9_1 | 1012_Vorinostat_1 | chromatin | 19_4911043_A_C |
| 688 | SLC9A7_1 | 1012_Vorinostat_1 | chromatin | 19_4911043_A_C |
| 689 | EIF4ENIF1_1 | 1091_BMS-536924_3 | igfr | 9_37887606_C_T |
| 690 | DOCK1_1 | 196_Phenformin_3 | metabol | 8_94407470_A_G |
| 691 | RPL32_1 | 300_CX-5461_3 | other | 8_12430448_C_T |
| 692 | PRICKLE2_1 | 185_Linsitinib_2 | igfr | 11_65547388_T_G |
| 693 | RUFY3_1 | 185_Linsitinib_2 | igfr | 11_65547388_T_G |
| 694 | WNT5A_1 | 185_Linsitinib_2 | igfr | 11_65547388_T_G |
| 695 | MPHOSPH10_2 | 275_I-BET-762_3 | chromatin | 15_75524142_T_C / 12_40313960_G_T |
| 696 | ARID3A_1 | 344_THZ-2-49_3 | cell_cyc | 8_7290003_A_C |
| 697 | HBQ1_1 | 344_THZ-2-49_3 | cell_cyc | 8_7290003_A_C |
| 698 | CAPG_5 | 305_TPCA-1_3 | other | 11_12162199_T_G / 10_11921140_T_G / 20_45938939_T_G / 1_156286332_T_G / 15_75783033_T_G |
| 699 | YARS2_2 | 1012_Vorinostat_1 | chromatin | 4_41632760_G_C / 4_41631305_C_A |
| 700 | KIAA0247_5 | 269_NSC-207895_3 | p53 | 1_149852603_A_G / 17_55774876_T_G / 16_18379704_T_G / 7_114630022_T_G / 19_15191478_T_G |
| 701 | ATP6V1A_1 | 1012_Vorinostat_1 | chromatin | 9_69516199_A_C |
| 702 | NFXL1_3 | 179_5-Fluorouracil_1 | DNArep | 17_55774876_T_G / 1_228244520_T_G / 20_16044565_T_G |
| 703 | RIOK3_3 | 293_Amuvatinib_2 | rtk | 2_61492168_C_A / 19_4679822_A_C / 1_1918305_G_A |
| 704 | AKR7A2_4 | 281_Alectinib_2 | rtk | 1_213007133_T_G / 17_55774876_T_G / 17_15651252_T_G / 1_451649_A_AG |
| 705 | THOC1_3 | 305_TPCA-1_3 | other | 1_44804312_T_G / 17_5474687_A_C / 8_68625531_T_G |
| 706 | COPG_1 | 1026_Tanespimycin_2 | other | 6_26897081_G_C |
| 707 | RPL13_1 | 185_Linsitinib_2 | igfr | 20_42084724_T_C |
| 708 | ARRB2_2 | 179_5-Fluorouracil_1 | DNArep | 2_170965958_A_C / 20_33848655_A_C |
| 709 | CCDC41_2 | 269_NSC-207895_3 | p53 | 9_86322936_ATTT_A / 9_86345023_C_T |
| 710 | WDR75_5 | 1012_Vorinostat_1 | chromatin | 3_196782572_G_T / 1_154331414_T_G / 7_149253814_T_G / 2_190469793_G_C / 18_14183954_G_T |
| 711 | LRBA_4 | 1011_Navitoclax_2 | apop | 13_114236659_T_G / 11_65547388_T_G / 2_178769713_G_T / 13_113159942_A_G |
| 712 | BAI3_2 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G / 6_30705792_T_G |
| 713 | FKBP4_1 | 1012_Vorinostat_1 | chromatin | 13_113325635_A_G |
| 714 | H3F3B_1 | 1012_Vorinostat_1 | chromatin | 13_113325635_A_G |
| 715 | LRRC45_1 | 281_Alectinib_2 | rtk | 17_6118065_A_G |
| 716 | VPRBP_1 | 1011_Navitoclax_2 | apop | 3_128945112_G_A |
| 717 | KIF1A_1 | 294_MPS-1-IN-1_3 | mitosis | 9_69516199_A_C |
| 718 | RPL3_1 | 294_MPS-1-IN-1_3 | mitosis | 2_24067801_G_A |
| 719 | ABI3BP_1 | 1012_Vorinostat_1 | chromatin | 16_87644643_G_A |
| 720 | FBRSL1_1 | 1091_BMS-536924_3 | igfr | 10_11921140_T_G |
| 721 | RAB3C_1 | 294_MPS-1-IN-1_3 | mitosis | 10_11921140_T_G |
| 722 | C16orf59_1 | 1012_Vorinostat_1 | chromatin | 19_9566733_T_G |
| 723 | NUP35_1 | 263_FR-180204_3 | erk_mapk | 19_9566733_T_G |
| 724 | LPIN2_1 | 344_THZ-2-49_3 | cell_cyc | 3_191357867_G_A |
| 725 | ZNF507_2 | 305_TPCA-1_3 | other | 11_65547388_T_G / 17_55774876_T_G |
| 726 | ADAM10_1 | 344_THZ-2-49_3 | cell_cyc | 17_63963708_T_C |
| 727 | FBXL18_1 | 344_THZ-2-49_3 | cell_cyc | 17_63963708_T_C |
| 728 | TMOD3_1 | 344_THZ-2-49_3 | cell_cyc | 17_63963708_T_C |
| 729 | HLCS_3 | 263_FR-180204_3 | erk_mapk | 14_67381608_G_T / 15_84241166_A_C / 17_43922689_A_G |
| 730 | NYNRIN_1 | 293_Amuvatinib_2 | rtk | 10_11921140_T_G |
| 731 | PDXK_1 | 344_THZ-2-49_3 | cell_cyc | 16_72164743_G_A |
| 732 | RPS11_3 | 1012_Vorinostat_1 | chromatin | 4_145127510_C_T / 17_28613683_A_C / 8_12430448_C_T |
| 733 | LCE2B_1 | 94_TGX221_3 | pi3k | 10_133753622_G_A |
| 734 | MAP2K7_3 | 1012_Vorinostat_1 | chromatin | 1_11243090_T_G / 12_109952676_A_C / 21_46245172_A_C |
| 735 | PATZ1_1 | 1012_Vorinostat_1 | chromatin | 11_12162199_T_G |
| 736 | SMCR7L_1 | 1012_Vorinostat_1 | chromatin | 11_12162199_T_G |
| 737 | CNTNAP2_1 | 196_Phenformin_3 | metabol | 8_7290003_A_C |
| 738 | SLC29A3_1 | 196_Phenformin_3 | metabol | 8_7290003_A_C |
| 739 | ZBTB34_1 | 185_Linsitinib_2 | igfr | 3_165019547_G_T |
| 740 | PRKAA1_2 | 294_MPS-1-IN-1_3 | mitosis | X_100585180_G_T / 3_128945112_G_A |
| 741 | IRF1_2 | 294_MPS-1-IN-1_3 | mitosis | 17_55774876_T_G / 12_51745916_T_G |
| 742 | GDAP1L1_5 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G / 16_1817242_T_C / 11_125626705_T_G / 9_128835995_A_C / 7_20404680_T_G |
| 743 | NUP205_2 | 290_KIN001-260_3 | other | 15_78476214_A_G / 10_19491534_C_A |
| 744 | NUS1_1 | 1011_Navitoclax_2 | apop | 1_147618935_T_C |
| 745 | GOLT1B_3 | 344_THZ-2-49_3 | cell_cyc | 16_72119226_C_G / 16_72129067_G_T / 16_72164743_G_A |
| 746 | SEC24A_2 | 1026_Tanespimycin_2 | other | 15_28382572_T_C / 7_5308283_G_A |
| 747 | AVEN_1 | 94_TGX221_3 | pi3k | 7_75422659_A_G |
| 748 | BRD3_1 | 1011_Navitoclax_2 | apop | 2_113934259_C_T |
| 749 | CBX5_1 | 1011_Navitoclax_2 | apop | 2_113934259_C_T |
| 750 | ZNF689_1 | 1012_Vorinostat_1 | chromatin | 3_53183591_A_C |
| 751 | RHOG_5 | 1194_SB-505124_3 | other | 5_427675_T_C / 16_1817242_T_C / 13_113159942_A_G / 16_30398066_C_A / 2_121418676_T_G |
| 752 | SPRY1_4 | 224_AS605240_3 | pi3k | 3_121642799_G_A / 3_121634481_A_C / 3_121699918_T_C / 3_121642940_G_A |
| 753 | NR1H2_2 | 1011_Navitoclax_2 | apop | 1_154627925_A_C / 1_150261398_T_G |
| 754 | RTKN2_1 | 294_MPS-1-IN-1_3 | mitosis | 6_73644452_C_T |
| 755 | CHRNA5_1 | 294_MPS-1-IN-1_3 | mitosis | 6_10410133_T_G |
| 756 | PEBP1_1 | 1011_Navitoclax_2 | apop | 4_108762737_T_G |
| 757 | CNOT6_1 | 196_Phenformin_3 | metabol | 1_16589114_C_T |
| 758 | FEM1B_1 | 263_FR-180204_3 | erk_mapk | 1_151048750_A_C |
| 759 | PDCD2L_1 | 151_QS11_3 | other | 2_196880031_T_C |
| 760 | BCCIP_2 | 1012_Vorinostat_1 | chromatin | 1_219979389_T_A / 19_11402175_A_C |
| 761 | C17orf80_2 | 344_THZ-2-49_3 | cell_cyc | 16_72119226_C_G / 16_72129067_G_T |
| 762 | TMEM229A_1 | 1012_Vorinostat_1 | chromatin | 6_30705792_T_G |
| 763 | AKAP1_1 | 344_THZ-2-49_3 | cell_cyc | 16_72119226_C_G |
| 764 | EPC2_1 | 344_THZ-2-49_3 | cell_cyc | 16_72119226_C_G |
| 765 | FKBP14_1 | 344_THZ-2-49_3 | cell_cyc | 16_72119226_C_G |
| 766 | HMGB1_1 | 344_THZ-2-49_3 | cell_cyc | 16_72119226_C_G |
| 767 | TMEM167B_1 | 344_THZ-2-49_3 | cell_cyc | 16_72119226_C_G |
| 768 | FURIN_1 | 281_Alectinib_2 | rtk | 2_113934259_C_T |
| 769 | FUZ_2 | 1012_Vorinostat_1 | chromatin | 10_73803641_A_G / 17_6118065_A_G |
| 770 | RAX_1 | 94_TGX221_3 | pi3k | 14_64951601_A_C |
| 771 | HSPA5_1 | 344_THZ-2-49_3 | cell_cyc | 1_165652085_TATTATC_T |
| 772 | SEZ6_1 | 294_MPS-1-IN-1_3 | mitosis | 3_128879626_CGT_C |
| 773 | CDC7_2 | 1011_Navitoclax_2 | apop | 6_73622013_G_C / 6_73635330_C_T |
| 774 | TIMELESS_2 | 1011_Navitoclax_2 | apop | 2_218827668_A_C / 20_48700966_A_C |
| 775 | FAIM2_1 | 294_MPS-1-IN-1_3 | mitosis | 3_127621040_A_G |
| 776 | PKIA_1 | 275_I-BET-762_3 | chromatin | 13_113159942_A_G |
| 777 | MRFAP1L1_1 | 304_SB52334_3 | rtk | 11_12162199_T_G |
| 778 | SLC4A8_1 | 1011_Navitoclax_2 | apop | 6_33296240_C_A |
| 779 | SAMM50_1 | 344_THZ-2-49_3 | cell_cyc | 17_76009153_A_C |
| 780 | FAM129A_1 | 263_FR-180204_3 | erk_mapk | 13_113159942_A_G |
| 781 | AFMID_5 | 1012_Vorinostat_1 | chromatin | 14_70800628_C_T / 12_6941768_C_A / 11_12162199_T_G / 3_119147558_G_A / 3_196782572_G_T |
| 782 | STARD7_1 | 344_THZ-2-49_3 | cell_cyc | 21_31701881_A_G |
| 783 | GPN2_2 | 300_CX-5461_3 | other | 17_55774876_T_G / 1_451649_A_AG |
| 784 | PCDH9_1 | 344_THZ-2-49_3 | cell_cyc | 3_75669056_G_A |
| 785 | DDOST_2 | 344_THZ-2-49_3 | cell_cyc | 1_16589114_C_T / 6_10398408_A_G |
| 786 | TMEM109_3 | 179_5-Fluorouracil_1 | DNArep | 13_113159942_A_G / 16_30398066_C_A / 5_141102658_A_C |
| 787 | OLA1_2 | 196_Phenformin_3 | metabol | 1_148117837_C_T / 1_146969331_G_A |
| 788 | RGS3_4 | 344_THZ-2-49_3 | cell_cyc | 2_241748788_C_T / 2_241748877_C_T / 2_241751260_G_A / 2_241744700_T_C |
| 789 | HMGCL_1 | 344_THZ-2-49_3 | cell_cyc | 1_16589114_C_T |
| 790 | SIPA1L1_1 | 344_THZ-2-49_3 | cell_cyc | 1_16589114_C_T |
| 791 | TMEM50A_1 | 344_THZ-2-49_3 | cell_cyc | 1_16589114_C_T |
| 792 | AP2S1_2 | 196_Phenformin_3 | metabol | 7_100951952_T_A / 7_100951953_T_A |
| 793 | NARF_1 | 304_SB52334_3 | rtk | 5_83553308_T_G |
| 794 | S100A2_2 | 1011_Navitoclax_2 | apop | 11_65547388_T_G / 17_55774876_T_G |
| 795 | STX8_2 | 94_TGX221_3 | pi3k | 7_100951952_T_A / 7_100951953_T_A |
| 796 | SLC10A4_3 | 1011_Navitoclax_2 | apop | 6_30329265_T_C / 16_1817242_T_C / 12_51745916_T_G |
| 797 | KCNAB1_1 | 294_MPS-1-IN-1_3 | mitosis | 19_17205202_T_G |
| 798 | NUFIP1_1 | 294_MPS-1-IN-1_3 | mitosis | 1_112520503_A_G |
| 799 | PUS7_1 | 1011_Navitoclax_2 | apop | 11_65547388_T_G |
| 800 | TMEM33_1 | 1011_Navitoclax_2 | apop | 11_65547388_T_G |
| 801 | SUPT4H1_1 | 281_Alectinib_2 | rtk | 1_247949628_T_C |
| 802 | B4GALT1_2 | 185_Linsitinib_2 | igfr | 13_113159942_A_G / 11_65547388_T_G |
| 803 | TRMT1_1 | 344_THZ-2-49_3 | cell_cyc | 12_8176004_A_C |
| 804 | ITCH_1 | 344_THZ-2-49_3 | cell_cyc | 1_13281477_A_G |
| 805 | SLC41A2_1 | 1527_Pictilisib_2 | pi3k | 4_118640836_A_T |
| 806 | UBXN1_1 | 1091_BMS-536924_3 | igfr | 10_73803641_A_G |
| 807 | AARS2_1 | 293_Amuvatinib_2 | rtk | 2_211420614_AAAAG_A |
| 808 | ASB13_1 | 1012_Vorinostat_1 | chromatin | 17_28613683_A_C |
| 809 | CSDA_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 810 | DBH_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 811 | DOK4_1 | 185_Linsitinib_2 | igfr | 13_113159942_A_G |
| 812 | FAM57B_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 813 | GRIA4_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 814 | IGFBPL1_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 815 | NFKBIZ_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 816 | PIEZO1_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 817 | SCN3B_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 818 | SNAP91_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 819 | TMEM151B_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 820 | TRAM1_1 | 294_MPS-1-IN-1_3 | mitosis | 13_113159942_A_G |
| 821 | DLGAP2_1 | 294_MPS-1-IN-1_3 | mitosis | 6_33279455_T_G |
| 822 | GFRA2_2 | 1011_Navitoclax_2 | apop | 5_38950065_A_T / 16_30953637_A_C |
| 823 | C12orf44_5 | 1011_Navitoclax_2 | apop | 8_72935904_A_T / 8_23202743_T_C / 15_40296801_A_G / 8_23201811_C_G / 9_134768529_A_G |
| 824 | CPD_2 | 1091_BMS-536924_3 | igfr | 16_30953637_A_C / 9_108900415_C_A |
| 825 | UNG_3 | 1011_Navitoclax_2 | apop | 7_108023984_G_A / 4_70722781_C_T / 3_52437514_T_G |
| 826 | AGAP2_1 | 263_FR-180204_3 | erk_mapk | 10_77108446_G_A |
| 827 | DPY19L4_1 | 294_MPS-1-IN-1_3 | mitosis | 7_149253814_T_G |
| 828 | UST_1 | 294_MPS-1-IN-1_3 | mitosis | 4_70722781_C_T |
| 829 | MAP2K7_1 | 344_THZ-2-49_3 | cell_cyc | 1_16734496_C_T |
| 830 | DLG1_1 | 344_THZ-2-49_3 | cell_cyc | 3_197683305_A_C |
| 831 | MAPK8IP2_1 | 185_Linsitinib_2 | igfr | 6_25669441_G_A |
| 832 | TARDBP_3 | 1011_Navitoclax_2 | apop | 11_65547388_T_G / 22_42212334_A_C / 15_65451964_A_G |
| 833 | CYLD_1 | 294_MPS-1-IN-1_3 | mitosis | 17_40348252_T_G |
| 834 | ATL2_1 | 294_MPS-1-IN-1_3 | mitosis | 3_38112112_T_G |
| 835 | SCAMP5_1 | 294_MPS-1-IN-1_3 | mitosis | X_100585180_G_T |
| 836 | ARL6IP5_1 | 196_Phenformin_3 | metabol | 14_102870248_A_C |
| 837 | TUBD1_1 | 276_CAY10603_3 | chromatin | 1_161021085_T_C |
| 838 | OLFM3_1 | 294_MPS-1-IN-1_3 | mitosis | 10_43200831_A_G |
| 839 | ODC1_2 | 310_YM201636_3 | other | 1_44339337_G_A / 15_75524142_T_C |
| 840 | EXOSC8_4 | 1011_Navitoclax_2 | apop | 6_73622013_G_C / 6_73635330_C_T / 2_127651579_A_C / 6_30705792_T_G |
| 841 | GEMIN5_4 | 1012_Vorinostat_1 | chromatin | 9_104837455_A_G / 8_42401781_A_G / 1_46261223_G_A / 15_72662708_A_C |
| 842 | BCLAF1_1 | 269_NSC-207895_3 | p53 | 11_65547388_T_G |
| 843 | ADAMTSL2_3 | 294_MPS-1-IN-1_3 | mitosis | 14_20996722_T_G / 8_122952205_T_G / 9_136745293_A_C |
| 844 | GSDMD_1 | 196_Phenformin_3 | metabol | 8_143559981_G_GAGGGCAGGGC |
| 845 | FILIP1L_1 | 344_THZ-2-49_3 | cell_cyc | 2_117977926_TAGTC_T |
| 846 | MPP5_1 | 344_THZ-2-49_3 | cell_cyc | 16_10941900_CGAA_C |
| 847 | ZNF781_2 | 1011_Navitoclax_2 | apop | 6_30705792_T_G / 11_65547388_T_G |
| 848 | GREB1_1 | 294_MPS-1-IN-1_3 | mitosis | 11_65547388_T_G |
| 849 | MICAL2_1 | 294_MPS-1-IN-1_3 | mitosis | 11_65547388_T_G |
| 850 | MLKL_1 | 304_SB52334_3 | rtk | 17_55774876_T_G |
| 851 | HIATL1_1 | 333_T0901317_3 | other | 1_13816508_A_G |
| 852 | POFUT2_3 | 344_THZ-2-49_3 | cell_cyc | 16_72119226_C_G / 16_72164743_G_A / 7_95495738_CT_C |
| 853 | FSD1L_3 | 1011_Navitoclax_2 | apop | 13_113159942_A_G / 11_12162199_T_G / 11_65547388_T_G |
| 854 | SLC22A4_1 | 294_MPS-1-IN-1_3 | mitosis | 2_60761746_T_G |
| 855 | ECE1_1 | 344_THZ-2-49_3 | cell_cyc | 3_196484004_T_C |
| 856 | FAM120C_1 | 179_5-Fluorouracil_1 | DNArep | 1_206458298_T_G |
| 857 | WDR18_1 | 1012_Vorinostat_1 | chromatin | 1_64663808_A_C |
| 858 | SPAST_2 | 305_TPCA-1_3 | other | 14_68291858_T_C / 4_158607939_A_AT |
| 859 | RIN2_1 | 344_THZ-2-49_3 | cell_cyc | 2_15474280_T_C |
| 860 | RUNX2_2 | 185_Linsitinib_2 | igfr | 11_12162199_T_G / 15_75268724_T_G |
| 861 | NOP14_2 | 1012_Vorinostat_1 | chromatin | 17_3513849_GCA_G / 9_36058818_G_T |
| 862 | MAN2B2_1 | 1012_Vorinostat_1 | chromatin | 17_55774876_T_G |
| 863 | PAIP1_1 | 344_THZ-2-49_3 | cell_cyc | 1_112659795_G_A |
| 864 | DHX32_2 | 344_THZ-2-49_3 | cell_cyc | X_119469587_A_G / X_119451980_A_G |
| 865 | PLK2_2 | 344_THZ-2-49_3 | cell_cyc | 3_9688859_C_T / 5_127331576_G_A |
| 866 | PRCC_1 | 1012_Vorinostat_1 | chromatin | 4_9908299_G_A |
| 867 | XAF1_1 | 344_THZ-2-49_3 | cell_cyc | 2_197498780_A_G |
| 868 | METAP2_1 | 344_THZ-2-49_3 | cell_cyc | 2_208237181_GA_G |
| 869 | CLK2_1 | 294_MPS-1-IN-1_3 | mitosis | 2_230875561_A_G |
| 870 | DPP6_1 | 294_MPS-1-IN-1_3 | mitosis | 19_43375573_G_T |
| 871 | ACSL4_3 | 344_THZ-2-49_3 | cell_cyc | 11_33583339_C_T / 11_33583414_C_T / 11_33606557_T_G |
| 872 | ANKIB1_1 | 1012_Vorinostat_1 | chromatin | 2_218827668_A_C |
| 873 | MRPL44_1 | 263_FR-180204_3 | erk_mapk | 10_11921140_T_G |
| 874 | ECSIT_1 | 344_THZ-2-49_3 | cell_cyc | 2_105307612_A_C |
| 875 | UTRN_1 | 344_THZ-2-49_3 | cell_cyc | 2_105307612_A_C |
| 876 | KLHL3_1 | 94_TGX221_3 | pi3k | 3_10062127_TA_T |
| 877 | PPP3CC_1 | 1011_Navitoclax_2 | apop | 15_77916965_T_C |
| 878 | ZNF146_2 | 276_CAY10603_3 | chromatin | 13_113159942_A_G / 3_196782572_G_T |
| 879 | ZNF561_1 | 156_AZD6482_2 | pi3k | 2_9954863_A_G |
| 880 | GABRB3_2 | 196_Phenformin_3 | metabol | 2_15474280_T_C / 2_15534562_T_C |
| 881 | FUCA2_2 | 294_MPS-1-IN-1_3 | mitosis | 1_185150475_G_A / X_54813054_T_G |
| 882 | ZNF704_1 | 196_Phenformin_3 | metabol | 11_120836935_C_T |
| 883 | RSRC2_1 | 179_5-Fluorouracil_1 | DNArep | 11_43920052_A_C |
| 884 | ZNF786_4 | 1166_QL-VIII-58_3 | tor | 16_72119226_C_G / 16_72164743_G_A / 16_72129067_G_T / 16_72150667_C_T |
| 885 | FAM208A_4 | 344_THZ-2-49_3 | cell_cyc | 1_103021838_CT_C / 8_7290003_A_C / 1_103002059_C_T / 1_102989661_C_T |
| 886 | KLC1_2 | 179_5-Fluorouracil_1 | DNArep | 6_30705792_T_G / 9_35801627_T_G |
| 887 | C4orf46_1 | 1011_Navitoclax_2 | apop | 1_44804312_T_G |
| 888 | PFDN2_1 | 1012_Vorinostat_1 | chromatin | 1_200988322_T_G |
| 889 | TMEM88_1 | 304_SB52334_3 | rtk | 15_63286530_C_T |
| 890 | CAMKMT_1 | 1009_Tretinoin_1 | other | 3_165019547_G_T |
| 891 | RAB3A_5 | 1091_BMS-536924_3 | igfr | 1_149852603_A_G / 15_75293000_T_G / 16_15664675_G_T / 1_150261398_T_G / 13_113325635_A_G |
| 892 | PPP1R3C_1 | 1012_Vorinostat_1 | chromatin | 1_172308705_AT_A |
| 893 | RNPS1_1 | 1012_Vorinostat_1 | chromatin | 6_26033581_T_TAAG |
| 894 | SESN1_1 | 185_Linsitinib_2 | igfr | 8_93815432_A_C |
| No. | FRH | Var_Exp(pval) | Var_Drug(pval) | Exp_Drug(pval) | Ave_VarDrug(pval) | Rank |
| 1 | PTRF_9 | 2.02E-17 | 0.000749693 / 0.000426098 / 0.009328967 / 0.000372589 / 0.006511221 / 2.35E-11 / 0.000116605 / 0.001047505 / 0.001374062 / 0.001565845 / 0.006047479 / 7.32E-05 / 0.006557575 / 9.01E-05 / 0.000574879 / 0.000160684 / 2.49E-05 / 0.002310424 / 0.000331474 / 0.000819278 / 9.28E-12 / 0.002957218 / 0.007844904 / 0.002619813 / 0.000685764 / 3.28E-05 / 0.007149858 / 1.82E-05 / 0.004659546 / 0.004062417 / 0.000187819 / 2.07E-07 / 0.004167431 / 0.001265165 / 0.002575563 / 0.000839515 / 0.008965476 / 0.00033059 / 4.72E-05 / 0.001888735 / 0.00646848 / 0.000714169 / 2.80E-07 / 0.001294695 / 0.000115716 / 3.08E-06 / 0.000261232 / 0.001910231 / 1.28E-06 / 0.004145356 / 0.003060428 / 0.006977625 / 0.001419304 / 7.63E-09 / 0.009439533 / 0.003871906 / 0.00072755 / 3.06E-06 / 0.003623857 / 0.001340666 / 0.008077047 / 0.000197417 / 0.003726859 / 0.001744921 / 0.006814012 / 0.007768596 / 0.001018135 | 8.86E-05 / 0.015861427 / 0.000935884 / 6.69E-06 / 0.001642604 / 7.15E-09 / 0.000114128 / 0.005567682 / 0.001713376 / 0.003771243 / 0.001845691 / 6.63E-05 / 0.000313526 / 0.002067719 / 0.000456029 / 0.003684593 / 5.74E-06 / 0.002204168 / 0.000228633 / 0.000400518 / 6.03E-07 / 0.000743512 / 0.012226314 / 0.024250323 / 8.17E-07 / 0.000107275 / 0.068108214 / 1.05E-05 / 0.245827021 / 0.000690655 / 0.00029549 / 3.30E-06 / 0.000963538 / 0.000798032 / 0.000737892 / 0.005284786 / 0.003534303 / 8.80E-05 / 0.004403153 / 0.004222642 / 0.006563798 / 0.000101882 / 5.52E-08 / 0.000895926 / 4.32E-06 / 2.39E-05 / 0.012076982 / 0.000700794 / 4.02E-08 / 0.000551546 / 0.005498224 / 0.005843004 / 0.004771885 / 7.03E-09 / 0.000449732 / 0.00773881 / 0.00481047 / 2.17E-06 / 0.029515032 / 2.54E-05 / 0.001228246 / 0.001095519 / 0.018900662 / 0.000306042 / 1.61E-05 / 0.007260065 / 0.036785468 | 0.00244 | 67 |
| 2 | MBTD1_5 | 0.0000000000 | 6.079058529181583e-06 / 0.000330234961590499 / 0.0009065836837091153 / 7.743250099097525e-08 / 5.4243318683013945e-06 / 6.638871076180972e-05 / 0.0001034540386175869 / 2.742943691390761e-05 / 8.864763064813537e-07 / 2.0409664165250274e-05 / 0.0014603495105780778 / 0.0002106217117458753 / 0.0020461746255640493 / 0.0008861613640617831 / 0.0014909983720721473 / 0.001580303435076526 / 0.00012171542819902834 | 2.8823341263186404e-09 / 7.828409458693464e-09 / 8.294895004123309e-09 / 3.2262810582910645e-08 / 1.8139300001511646e-07 / 1.8402518116440838e-07 / 2.67841045277985e-07 / 1.5039088850140218e-06 / 1.3222940844102726e-06 / 1.2562395947292494e-06 / 0.00019219761010832952 / 8.314417317729093e-07 / 1.370078882045095e-05 / 6.768156840167973e-06 / 1.0455349186526601e-05 / 2.2476152083519155e-06 / 3.022593119181365e-06 | 0.000545 | 17 |
| 3 | C12orf29_4 | 0.0000000000 | 4.824002117845577e-08 / 0.005441831791967279 / 1.1897498080889868e-05 / 2.832726371483715e-06 / 3.554190719208408e-05 / 9.98122338478244e-05 / 0.00019780761336601855 / 1.2166594948453657e-06 / 0.0013399032530365647 / 0.010366551109197954 | 9.831623775837906e-08 / 1.1424232521759333e-06 / 4.317636814226818e-05 / 1.4382106269639384e-06 / 1.565031148370116e-06 / 0.0001061775620019226 / 7.880009857538694e-07 / 5.059091238516106e-06 / 6.9124096914811e-05 / 3.7455065294802056e-05 | 0.00175 | 10 |
| 4 | DDX20_1 | 0.0000010604 | 9.390951294242489e-05 / 0.003291125326808141 / 6.606509042863372e-05 / 0.0009706006123489501 / 0.00033173858745018413 / 2.8301251379202592e-05 / 0.002989009151291833 / 0.0003464118358647972 / 4.611763366846969e-05 / 0.010271987936204268 | 1.8690130781974698e-08 / 1.7049356788275527e-06 / 4.90739703689557e-07 / 2.1664146971003018e-07 / 2.2579476817862133e-07 / 2.2223004763773554e-07 / 1.487681859612425e-06 / 5.806089896300099e-06 / 5.518438170954557e-07 / 3.9629751093887545e-06 | 0.001844 | 10 |
| 5 | TACC1_4 | 0.0000000000 | 3.87018819160593e-07 / 7.839796663490128e-06 / 0.0211517389620851 / 0.0007385583772737821 / 0.0001541124146376614 / 0.000740753187661269 / 0.00010956462066226552 / 0.0005066082079176534 / 0.00031180764933246263 / 0.0002656005692813481 | 1.8794101118497154e-10 / 5.932840218364882e-08 / 1.3308222183335375e-05 / 3.6611240087061e-07 / 1.9891885346261133e-06 / 2.780203755383467e-06 / 7.920522224234305e-06 / 4.233437731609824e-05 / 1.3783248323482445e-06 / 8.71500241588669e-06 | 0.002399 | 10 |
| 6 | SFPQ_1 | 0.0000000779 | 4.611763366846969e-05 / 6.606509042863372e-05 / 9.390951294242489e-05 / 0.0021892065422244767 / 0.002989009151291833 / 2.8301251379202592e-05 / 0.006770110957154303 / 0.003291125326808141 / 0.00018869114988485987 / 0.023379270483941148 | 1.6421685468372866e-11 / 2.7347777767986492e-08 / 6.012098925210058e-08 / 2.202165084592466e-05 / 9.663054308166113e-05 / 8.127505856380939e-07 / 1.0837751787086504e-05 / 8.284871105188379e-05 / 1.8339230937241138e-06 / 7.704856579616509e-05 | 0.003904 | 10 |
| 7 | LRPPRC_2 | 0.0000000013 | 1.2022019578742027e-05 / 0.0003761548279529811 / 0.0037244088642669265 / 0.0021708592883619747 / 0.0001663224278721914 / 0.023108708224531857 / 2.9430765473148166e-05 / 0.01050357293743899 / 0.020115537840238746 / 0.010524107924498233 | 5.209483330257566e-10 / 8.01050796462614e-08 / 2.4695473842016646e-07 / 8.371111187295495e-08 / 5.106669850809745e-07 / 4.686091200519956e-06 / 1.3349886552198077e-08 / 1.915969698573113e-06 / 2.9107217405524718e-06 / 2.5997671669797386e-05 | 0.007073 | 10 |
| 8 | ILF3_5 | 0.0000000000 | 1.3887956173777372e-05 / 1.6939519588941488e-05 / 9.786382578515826e-08 / 0.0007340541171379744 / 3.1279199929494124e-06 / 9.697231213241931e-06 / 0.0003946275449128456 / 0.0013987772568790748 / 0.0011249003808451194 | 1.7515743716180326e-07 / 3.0845658986771253e-07 / 6.542843309537432e-09 / 1.1331609020935322e-06 / 4.268164739909969e-07 / 1.315856013252508e-05 / 7.875046335838071e-06 / 4.114385321933064e-07 / 2.3594761771202245e-05 | 0.000411 | 9 |
| 9 | ATXN7L3B_5 | 0.0000000000 | 2.612066597760477e-06 / 0.00011479613384953161 / 7.334368900690378e-11 / 0.0010577852528073678 / 9.018479144369487e-06 / 9.409687610838478e-05 / 0.003583481340909988 / 1.7599872572764645e-05 / 0.0008387169638839557 | 2.969448250016487e-08 / 1.9600165258234536e-07 / 4.2990302404127387e-08 / 2.1159749013263597e-06 / 1.0277412362510468e-05 / 2.2327592321063564e-05 / 2.749246019785697e-06 / 2.702131319979186e-05 / 6.193347041468136e-06 | 0.000635 | 9 |
| 10 | CENPV_1 | 0.0000001156 | 0.006820424547488444 / 1.2412020538304333e-05 / 0.004148676908553548 / 0.005770181686062503 / 0.019668015814206605 / 0.0025299472548494955 / 0.005078710464709388 / 0.0004338260851758113 / 0.03879612345050204 | 1.6083375617695613e-06 / 1.8297985260415566e-08 / 5.676604686582581e-08 / 4.561722639281827e-07 / 2.7263615702723626e-06 / 6.194080837624687e-07 / 1.2533181199972694e-06 / 0.00011131713990719029 / 4.864543347378877e-07 | 0.009251 | 9 |
| 11 | CAMKV_4 | 0.0000000014 | 5.551416714792332e-06 / 0.0008366625106022517 / 0.0005748885432290085 / 2.2091746366723067e-05 / 0.0012478612516330242 / 0.0013687527180138105 / 1.5647557069044988e-05 / 5.021668210368932e-05 | 4.61338946784834e-09 / 8.552882219336728e-06 / 1.2084936819520143e-05 / 7.064438585065973e-06 / 0.0003375551467252637 / 1.1640523808727713e-05 / 7.01115214482234e-05 / 4.699480658072907e-05 | 0.000515 | 8 |
| 12 | TPMT_3 | 0.0000000000 | 7.28786952864283e-07 / 3.56646279188718e-05 / 9.6666658281473e-06 / 0.000778043526031782 / 0.0009044201128473978 / 0.0021692955083051683 / 0.0005370416183224255 / 9.028956735669806e-05 | 1.4274492942468779e-08 / 1.0767623030922322e-08 / 5.322824205944157e-10 / 6.914371271776401e-08 / 3.193252019194024e-06 / 3.3380153156051058e-06 / 1.3843642927526513e-06 / 1.514974348380039e-05 | 0.000566 | 8 |
| 13 | WASF1_3 | 0.0000000001 | 3.6965068162525554e-06 / 0.0012954933098786366 / 1.5026939104998247e-05 / 6.092048706938309e-06 / 5.7827307263502816e-05 / 3.710694976569371e-08 / 2.4065055735879793e-06 / 0.0066209312465568835 | 1.8963621043904114e-06 / 1.942674022825637e-09 / 1.4008670359077526e-07 / 7.984757203592169e-07 / 1.807601980567127e-06 / 1.014708711120146e-06 / 9.411427127533182e-07 / 2.7376810453016147e-06 | 0.001 | 8 |
| 14 | DDX25_4 | 0.0000000000 | 4.227069860488674e-06 / 1.1933180927019854e-06 / 1.275889510970952e-05 / 0.00014312717982028765 / 0.0001971578481272282 / 0.0007128346948758641 / 0.005660294390019774 / 0.002987411679461687 | 5.868503968366881e-07 / 1.6672256393335718e-07 / 7.607024358338446e-07 / 4.007532632723821e-06 / 5.422908721198046e-06 / 4.226087433911996e-06 / 1.9844578914555127e-05 / 1.348050130807739e-05 | 0.001215 | 8 |
| 15 | ACVR2B_5 | 0.0000000000 | 0.00031701458152281776 / 4.014660005410256e-05 / 8.837943468799988e-05 / 1.2223170855538867e-05 / 0.00417544874823594 / 0.00027313653971257405 / 0.006738885955615125 / 0.00033890163674631904 | 4.22669945715201e-07 / 7.742783641708327e-10 / 2.0483971869730718e-07 / 1.239958147162055e-07 / 4.939171357902516e-05 / 4.120212263097594e-06 / 0.0006361321771264191 / 2.7380093694423655e-05 | 0.001498 | 8 |
| 16 | TAP1_4 | 0.0000000000 | 1.049031460757783e-06 / 0.0003635757182364942 / 3.753398348762388e-07 / 0.00028733812150622895 / 0.0007167010349785833 / 2.307106816252697e-05 / 5.337901424957087e-05 / 0.020106125155811467 | 1.3332679478124245e-07 / 1.1868875335385447e-05 / 2.7070790605645726e-06 / 7.056569159589176e-06 / 0.0002157049138716117 / 4.445857267298034e-06 / 3.642358929245767e-05 / 2.406762142831913e-06 | 0.002694 | 8 |
| 17 | SMPD1_1 | 0.0000009495 | 0.003065043011644369 / 0.0023157697041580965 / 0.0012909968347916095 / 0.0006256240573576323 / 0.007223252257555813 / 0.03771188975485943 / 0.0003890294490866307 / 0.00736333395639105 | 5.955099761237206e-13 / 3.051847715980306e-09 / 1.8525537737343062e-08 / 6.490954203776185e-06 / 9.743943487605562e-08 / 1.3599979831920288e-06 / 8.962608566425138e-06 / 5.6013193436695554e-06 | 0.007498 | 8 |
| 18 | PEA15_5 | 0.0000000000 | 0.0002596888575908078 / 0.0013300138356594274 / 0.00524721075079139 / 0.006442952776112118 / 0.018912868681800837 / 0.01937026642721713 / 0.01438287077969559 / 0.0004932314709699339 | 4.44845454863038e-09 / 1.0130302320647733e-07 / 4.515074038541242e-07 / 2.962208123523371e-06 / 1.8659873824466947e-06 / 2.323546008318182e-06 / 2.7318856566845997e-06 / 1.1792288071015321e-05 | 0.008305 | 8 |
| 19 | SLC25A43_1 | 0.0000001166 | 0.0012903447119515423 / 0.004158933151515996 / 0.008351774878422811 / 0.04843122350083363 / 2.540557327027098e-05 / 0.0003105144729205529 / 0.010869042090733612 / 0.02588573867516253 | 1.891414179412052e-09 / 2.1049137124860745e-07 / 5.230089820717235e-09 / 8.635969388699494e-07 / 5.5411681205887995e-08 / 7.317272575393834e-07 / 4.148735135683505e-07 / 3.228573281191034e-05 | 0.012415 | 8 |
| 20 | MT2A_5 | 0.0000000000 | 0.00011447752236282417 / 0.0002544633476725284 / 0.00017859214428829218 / 0.0005165077368872941 / 0.00014503469256866046 / 0.000601999882354011 / 9.573116134444548e-05 | 1.584500848087154e-07 / 2.51478016245715e-07 / 8.54720361712193e-07 / 6.516915144267419e-06 / 5.171536692079251e-06 / 8.802100259189991e-06 / 1.6314636428146748e-06 | 0.000272 | 7 |
| 21 | RUNX1_2 | 0.0000000000 | 0.0005559642828812122 / 0.0008971360026655244 / 0.0009701318251119559 / 1.7922091488637388e-05 / 0.00017935064903782676 / 0.0025863116474804755 / 0.0001657906685047857 | 1.9576595780585085e-10 / 2.1776070811919277e-07 / 7.527037299722958e-07 / 2.559009185958782e-07 / 2.2176040120466972e-05 / 2.5598942326458564e-06 / 8.17316116112682e-06 | 0.000768 | 7 |
| 22 | LRRC8B_3 | 0.0000000000 | 9.4941920370122e-06 / 0.0015781807884715357 / 0.0002622885842506721 / 0.0011548969209222207 / 0.005697781111749079 / 7.700053244511214e-06 / 0.001483718198167863 | 4.296394955066174e-08 / 1.4324682153058617e-05 / 1.7104030080984345e-05 / 7.565682931060495e-07 / 1.624606018039645e-05 / 4.1115916939474605e-06 / 5.004433338367946e-06 | 0.001456 | 7 |
| 23 | PSMB9_4 | 0.0000000000 | 1.1255116843939685e-06 / 7.444306538180959e-05 / 8.121302745530734e-05 / 0.006696643814464557 / 0.0001492527064854631 / 4.25829047419839e-06 / 0.003283436953926786 | 5.9405281136078796e-08 / 4.799096156918887e-07 / 6.170625684612102e-06 / 1.4805988081664244e-06 / 1.6676304471263215e-05 / 2.337476084860884e-05 / 2.138799423764577e-05 | 0.00147 | 7 |
| 24 | RRAS_5 | 0.0000000000 | 8.182509603383713e-07 / 0.00021369162894747652 / 0.003190351183802246 / 0.00679937164887004 / 9.99040056201094e-06 / 0.002342765582078353 / 0.00018160002648956962 | 2.876707427462528e-08 / 6.680110293230449e-07 / 5.972855062819303e-07 / 2.8451937899285467e-05 / 7.687368595573398e-06 / 7.477786594755585e-07 / 1.3224569563917872e-06 | 0.00182 | 7 |
| 25 | TMBIM1_5 | 0.0000000000 | 2.322967022611346e-06 / 4.188818420450373e-05 / 8.859519927799691e-07 / 6.20461992462773e-05 / 0.00026413620242118544 / 0.00014398625006041495 / 0.014948105524536974 | 9.353599152353929e-08 / 5.844591678215266e-07 / 1.5978510581326625e-07 / 9.291490547025219e-07 / 2.7475634725757366e-07 / 4.753956509088212e-05 / 9.311198865860414e-07 | 0.002209 | 7 |
| 26 | KLHL23_3 | 0.0000000004 | 0.00012805365107500054 / 0.002519598458842781 / 0.0004515536091125032 / 0.00022680614492479574 / 0.009733620762754698 / 0.0042912100983332774 / 4.9219858574682586e-05 | 9.921726897145688e-09 / 8.717866079599918e-06 / 8.841783359385233e-07 / 1.1383657613478495e-06 / 0.0008824236923248849 / 3.398353518910182e-05 / 5.795994893765768e-07 | 0.002486 | 7 |
| 27 | EWSR1_1 | 0.0000005663 | 2.098169823270148e-06 / 0.00920357999307954 / 1.7711409436331332e-05 / 0.0014863302195178008 / 0.0014863302195178008 / 0.005409509534570436 / 1.9786173221795818e-05 | 4.043867582082559e-07 / 8.844612889243844e-05 / 2.099411528051961e-06 / 6.37244282155154e-05 / 3.479676125457968e-06 / 4.563731385373264e-06 / 8.51275649150399e-06 | 0.002518 | 7 |
| 28 | ZNF124_3 | 0.0000000174 | 0.01185115455025083 / 0.0028820143512348784 / 0.0006400036981941583 / 0.00022237327343913756 / 0.0017326407356747695 / 0.0002237032245520265 / 0.0002896824687842766 | 3.830190864530467e-08 / 0.0005023437846254026 / 1.4341269466072291e-05 / 1.9187040433353085e-05 / 3.0536343957588886e-05 / 0.00015912558081257976 / 0.00030057122653906633 | 0.002549 | 7 |
| 29 | CAPG_2 | 0.0000000000 | 0.00016360654996415964 / 0.003107700700013517 / 0.004526868535758527 / 0.003825441026009639 / 0.00040288084200566923 / 3.2262553686676067e-08 / 0.006275421665752097 | 1.6061695068770962e-09 / 6.708972026453563e-07 / 6.9252484921311626e-06 / 8.27034474165013e-06 / 9.342485200961395e-05 / 8.711780875641735e-07 / 5.302432363858073e-06 | 0.002615 | 7 |
| 30 | TGOLN2_2 | 0.0000000030 | 0.0002870649623628604 / 0.005727463389908907 / 1.203780953398585e-06 / 0.00027661203249205183 / 0.0005689555709178733 / 0.0006501827815986053 / 0.014330254737635668 | 3.619262458649237e-11 / 4.769486326622182e-08 / 1.6622051928852046e-08 / 3.6038229751219804e-07 / 4.940074588134348e-05 / 1.8592574634706461e-06 / 7.392344957282081e-05 | 0.00312 | 7 |
| 31 | RBFOX1_1 | 0.0000008465 | 0.0006456808009902826 / 0.0009805618383529596 / 0.0005802206884848052 / 0.0007177403550416762 / 0.00731321321837694 / 0.0011231690936696782 / 0.010617152378270862 | 2.2848739279053027e-11 / 3.403410943591806e-08 / 5.3253671669888775e-06 / 5.391441835390658e-06 / 9.82032865139159e-07 / 4.249582206860703e-06 / 4.042294162166094e-06 | 0.00314 | 7 |
| 32 | RANBP2_2 | 0.0000000020 | 0.0032005645957622507 / 1.1292974727160135e-05 / 0.004582586266801288 / 0.005968942599275744 / 0.0007669246686613953 / 0.0003836018962680972 / 0.01256992621275457 | 1.0278781040318966e-06 / 3.2181914215686755e-07 / 9.03950843772086e-07 / 2.2352937628807305e-06 / 1.2237851910310582e-05 / 2.3260388622347645e-06 / 3.157729990156927e-05 | 0.003926 | 7 |
| 33 | CCT2_1 | 0.0000000610 | 0.00037839447623271325 / 0.00042879723237597764 / 0.001443320215490813 / 0.00028286232014178015 / 0.008201744521300066 / 0.002944369153927747 / 0.01649068093735444 | 1.2749486030115433e-08 / 1.1225851282580173e-07 / 6.873884305086476e-09 / 2.2752402825301866e-07 / 1.0015662188091184e-06 / 3.453963505596524e-06 / 5.058184693460015e-06 | 0.00431 | 7 |
| 34 | CEP95_2 | 0.0000000004 | 0.0007190070321581675 / 0.0002545171218429651 / 0.0035966015072663835 / 0.0025521170193974763 / 0.0003107381669592285 / 0.027502917617089746 / 0.0012110736028058307 | 1.3949676285490207e-07 / 2.1170919481613956e-08 / 2.8596627227079915e-05 / 9.032373803983716e-08 / 4.00753265620622e-06 / 6.457362557632581e-06 / 4.791358118111102e-07 | 0.005164 | 7 |
| 35 | GINM1_3 | 0.0000000000 | 2.8556636750809756e-05 / 0.00012092027077076626 / 0.004350456289105647 / 0.0028744599511057625 / 0.009781859661254071 / 0.012315629622740824 / 0.014183888091677869 | 3.741940140138828e-09 / 6.30551384179601e-07 / 5.723523849148954e-07 / 4.137409181237638e-07 / 4.058957920972812e-06 / 1.324094056480911e-05 / 5.334206696833551e-06 | 0.006237 | 7 |
| 36 | POLG2_2 | 0.0000000067 | 0.0002576770516093337 / 0.0016833422652258513 / 0.01537032415812942 / 0.0199546774517756 / 0.011879693396648705 / 0.013778504455704959 / 0.0006073423559504219 | 8.002612553216828e-12 / 2.5154718511604325e-07 / 5.542657615241579e-07 / 6.569612124521097e-06 / 5.133965042123324e-06 / 4.188709032414043e-08 / 6.35362381394998e-07 | 0.009076 | 7 |
| 37 | RAN_2 | 0.0000000007 | 8.10356681117687e-05 / 0.0015745833133913741 / 0.0003323999875867436 / 0.014323464285551478 / 0.003484183595989438 / 0.0003293358901815535 / 0.045671136243731716 | 4.467053904818645e-09 / 8.90912425766829e-06 / 2.7276695958874614e-07 / 1.6612137127547922e-06 / 4.295327136339735e-06 / 0.00010945540484186873 / 0.0007487722885105004 | 0.009399 | 7 |
| 38 | MTF2_2 | 0.0000000001 | 0.00024102538797346086 / 0.001539940029122352 / 0.005818462625160796 / 0.04331587497952318 / 0.003473006180561586 / 0.013123198329328149 / 0.0011086944827796786 | 5.524058788809012e-07 / 2.255174371885246e-07 / 1.0230509628865922e-08 / 1.5272339234163363e-06 / 4.502242650312079e-06 / 1.4470801258175914e-06 / 4.0947329724111495e-06 | 0.009803 | 7 |
| 39 | CMPK1_1 | 0.0000099465 | 0.01615823448153983 / 0.03373282648472924 / 0.016556829420777325 / 0.01344459083967992 / 0.0011586570434241133 / 0.007942503974326632 / 0.006386843886902124 | 2.364261967442666e-08 / 5.989349364171967e-07 / 1.051890467879646e-07 / 2.8069595654757565e-06 / 2.675202019953556e-06 / 4.952772665629785e-06 / 8.5101324606656e-06 | 0.013626 | 7 |
| 40 | MDN1_1 | 0.0000149331 | 0.027136920905959004 / 0.015382714940475899 / 0.0002021790532799894 / 0.025082579510674555 / 0.002667939855033078 / 0.01903033340546255 / 0.023433853775319136 | 3.1384912120068307e-10 / 9.325247533918398e-06 / 6.936897377329882e-07 / 2.353698101267621e-06 / 1.4783005405825795e-05 / 1.3845703258818903e-06 / 3.794277797288223e-07 | 0.016134 | 7 |
| 41 | INPP1_2 | 0.0000000458 | 0.00012405403034171616 / 1.718785742696879e-05 / 6.396622257100077e-06 / 6.925570695765487e-06 / 3.9200560425745034e-05 / 1.2385564215356241e-06 | 5.3962567655992866e-05 / 8.480907105422951e-07 / 2.8149687924382837e-07 / 6.886821060328188e-06 / 4.946024817438151e-06 / 2.5531357893982e-06 | 3.25E-05 | 6 |
| 42 | TOMM20_5 | 0.0000000000 | 9.847481167714172e-07 / 5.461787394016582e-07 / 2.630785074908594e-05 / 6.807575706103957e-07 / 6.31788143549132e-07 / 0.0002787072964560934 | 1.828485836400758e-09 / 8.488593461887543e-08 / 4.561158256034957e-06 / 1.357508261446604e-07 / 2.9348649605847958e-06 / 1.3733983916997187e-05 | 5.13E-05 | 6 |
| 43 | S100A6_3 | 0.0000000000 | 3.987563090636182e-09 / 6.751332523310354e-08 / 5.131148780828573e-06 / 5.346137072472972e-07 / 0.0008192357956865613 / 1.657842655825674e-06 | 1.8859563430955987e-09 / 1.5597048970633669e-07 / 6.731790637644895e-07 / 3.923562825747655e-06 / 7.57844698984901e-05 / 1.7516083103081196e-06 | 0.000138 | 6 |
| 44 | ZNF74_5 | 0.0000000000 | 7.220170669604226e-07 / 0.000560135938998767 / 3.1675474781598684e-05 / 0.0005276313183088553 / 2.1660265856759415e-06 / 0.00015601716830048032 | 1.4629848729112387e-07 / 1.1761012404538385e-06 / 4.011024961679582e-05 / 2.0573826720469716e-06 / 2.0056325015251253e-05 / 3.125081554604303e-05 | 0.000213 | 6 |
| 45 | ZNF195_3 | 0.0000000000 | 4.2041150573934295e-05 / 4.5529669866602804e-05 / 0.0007203033990971563 / 0.00014468246920967197 / 0.00031951653993607604 / 8.595632585615447e-05 | 6.719675625838534e-09 / 3.8056480729458196e-09 / 7.723330075061024e-07 / 3.1795531703660226e-06 / 4.735362185795e-06 / 1.0975067398076295e-06 | 0.000226 | 6 |
| 46 | DNMT3A_2 | 0.0000000000 | 6.115665040218944e-06 / 3.206324028832219e-05 / 8.429951747175733e-05 / 0.00019962122279230926 / 5.615553156462022e-07 / 0.0021806139002983004 | 1.511429559536217e-08 / 3.3834848660671585e-06 / 1.0925063596049997e-07 / 6.95434985454603e-08 / 4.9915249752075324e-06 / 2.7418564056278035e-05 | 0.000417 | 6 |
| 47 | PXDC1_3 | 0.0000000000 | 0.00018564783748412937 / 0.0006324544157642112 / 0.0008799932868837088 / 0.0012100854406902743 / 2.4460595957570077e-05 / 9.238919654315156e-05 | 1.629093796438785e-09 / 2.354828010860969e-08 / 1.1437120990282457e-06 / 2.506826726053496e-07 / 1.4404482300034928e-05 / 1.341496646230468e-07 | 0.000504 | 6 |
| 48 | HOXD8_1 | 0.0000011390 | 1.384655004104117e-06 / 2.098169823270148e-06 / 0.00013057839781136293 / 0.0006273187563236247 / 0.002391299161389133 / 0.00012418009082273935 | 4.462177612672371e-06 / 3.7108705034506107e-07 / 2.588422064155111e-06 / 4.951039991487746e-05 / 1.3325001401014987e-05 / 0.00014465241485038646 | 0.000546 | 6 |
| 49 | CREB3_5 | 0.0000000000 | 0.00011974638832910611 / 2.8492275991361182e-06 / 0.0002672299360603039 / 0.0015619495448511997 / 0.0006694225755824582 / 0.0007820104355851261 | 3.367539235619778e-08 / 2.960146168251713e-09 / 3.5507108068252503e-07 / 1.15634806074712e-07 / 9.547786692388759e-08 / 9.283068268133278e-07 | 0.000567 | 6 |
| 50 | HDAC2_5 | 0.0000000000 | 0.0024571245521046946 / 0.00027132067925628834 / 9.682089638458799e-05 / 0.0005745209404259057 / 0.0011143521019561335 / 8.813885171995659e-06 | 5.2270805905618696e-06 / 5.052158985938859e-07 / 2.8819687490380823e-06 / 2.0125230234433194e-05 / 2.0453412309359413e-06 / 2.7524824404052385e-05 | 0.000754 | 6 |
| 51 | TIMP1_5 | 0.0000000010 | 0.0007131856153707479 / 0.004395200198238863 / 0.0007246067046570448 / 0.0004898581392129352 / 0.0005314272666539294 / 0.0011397228331407 | 5.172684196778569e-07 / 2.311501161730639e-05 / 3.21307883800088e-06 / 6.009010264662183e-07 / 8.327439275864646e-05 / 1.1941646912994778e-05 | 0.001332 | 6 |
| 52 | COQ10B_2 | 0.0000000036 | 0.00028381156148520563 / 0.0011945192630844516 / 9.355412559125023e-05 / 0.00011447010352733596 / 0.004266156536665072 / 0.006336011637689165 | 9.039504276825803e-09 / 6.006195461219958e-11 / 1.974259905174528e-07 / 1.2053082748861081e-06 / 5.363487408950924e-07 / 6.630188454539638e-06 | 0.002048 | 6 |
| 53 | REEP5_3 | 0.0000000001 | 0.0002604645915174344 / 1.6662214108439007e-05 / 0.0014440576489070092 / 0.007046402501490371 / 0.0001422863963685906 / 0.003637547802268041 | 1.5498910474749387e-08 / 1.5248778277061658e-07 / 4.842659456067433e-07 / 1.1491084964019146e-05 / 9.94537200846768e-06 / 1.9463332862931604e-06 | 0.002091 | 6 |
| 54 | FAM111A_5 | 0.0000000000 | 4.4898969618553406e-05 / 2.4668455632971913e-06 / 0.008396935784803085 / 2.1285938805234283e-05 / 0.00017201334171284462 / 0.00396513630435739 | 2.8379627983912504e-07 / 5.011442931035688e-06 / 2.7338260851547263e-06 / 8.36960570585275e-07 / 0.0001410578503689771 / 0.00014811827476060585 | 0.0021 | 6 |
| 55 | XPO5_2 | 0.0000000001 | 0.0001209623595819047 / 0.000188340547489593 / 0.0018652619870494437 / 0.00021645065939681314 / 0.003380556290063177 / 0.008610130886641778 | 3.868080212014016e-11 / 9.213293248318617e-08 / 1.7999848646465621e-06 / 2.4843669693960186e-06 / 4.8157427373392145e-06 / 1.6123249086459064e-06 | 0.002397 | 6 |
| 56 | MICALL2_2 | 0.0000000015 | 0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 / 1.9308695609987287e-05 / 0.00038134035343875063 / 0.012364148039779468 | 7.498455684868167e-10 / 1.4582924103607157e-08 / 1.3913032862815633e-07 / 5.643046267928915e-06 / 9.075353821264667e-07 / 6.490175971759533e-07 | 0.00274 | 6 |
| 57 | ITGA3_1 | 0.0000000030 | 0.005770181686062503 / 1.2412020538304333e-05 / 0.0014786332863597391 / 0.0025299472548494955 / 0.006820424547488444 / 0.0005531418384342248 | 5.922775528802422e-07 / 4.6735775256735116e-07 / 1.1163600156129396e-05 / 1.4439518922300546e-05 / 2.1428615198188343e-05 / 0.0004769133582838131 | 0.002861 | 6 |
| 58 | MATR3_5 | 0.0000000205 | 0.011926215274063212 / 0.0009331303043566046 / 0.0010276150171031416 / 0.00182336903581431 / 0.0003580914875982602 / 0.0015078412320002777 | 4.924418504897322e-07 / 1.370559303361593e-06 / 1.6001662179812555e-07 / 1.1659751397403969e-06 / 3.3107751763197302e-06 / 0.00023808544096258719 | 0.002929 | 6 |
| 59 | SAT1_1 | 0.0000002126 | 0.00037839447623271325 / 0.00010681753824403367 / 0.001443320215490813 / 0.00028286232014178015 / 0.00042879723237597764 / 0.01649068093735444 | 2.471908559304084e-08 / 1.0167276826134301e-07 / 4.27349479221232e-08 / 1.9148903772583427e-06 / 5.811635331171456e-06 / 2.062293334552713e-06 | 0.003188 | 6 |
| 60 | TMED9_2 | 0.0000000049 | 0.004580742781866771 / 0.00013157696997892983 / 0.004688381529867688 / 0.009588847065017484 / 0.002359920632447335 / 2.045294378465323e-05 | 2.311738097680596e-07 / 3.385203606751943e-07 / 1.428134704742174e-06 / 2.2508154783841546e-06 / 8.005735739477652e-07 / 5.167281077719583e-06 | 0.003562 | 6 |
| 61 | KIF26A_2 | 0.0000000001 | 1.5469524150486244e-06 / 8.296463018176517e-06 / 0.006895380226562706 / 0.012900561921483814 / 0.0032271260560706324 / 0.00021924462904813837 | 1.5344327905473364e-07 / 2.061988698426251e-05 / 8.65696212540371e-05 / 0.00020969562979674127 / 2.9068598486233544e-05 / 7.962530247357052e-05 | 0.003875 | 6 |
| 62 | C19orf66_2 | 0.0000000010 | 0.00034498616340953534 / 0.011682032301995177 / 0.00022585824160449916 / 0.0007089738037200934 / 0.002717071783164195 / 0.0083826665816656 | 1.6212467312990448e-07 / 8.055304607431e-07 / 2.1285718913705297e-05 / 6.7336653328809105e-06 / 9.184791210195023e-06 / 5.963654428661317e-05 | 0.00401 | 6 |
| 63 | GTF3C2_2 | 0.0000000532 | 1.1143488565728274e-05 / 6.351892014238265e-06 / 0.00014033845457246834 / 0.0056660681635887335 / 0.018064176445119352 / 0.001679572583230773 | 5.3778331923390924e-09 / 3.451157087485289e-08 / 1.036058010685455e-05 / 6.86847495002417e-07 / 2.1756858153773495e-05 / 1.4832082275306326e-07 | 0.004261 | 6 |
| 64 | ADAM9_5 | 0.0000000000 | 9.192181643816992e-05 / 0.01456393928510654 / 0.0024406101382475976 / 0.0003651548756090639 / 0.002859171921278692 / 0.005910547863522942 | 1.2444797620355103e-06 / 0.0006441060918252728 / 6.0935458892623245e-06 / 2.470519395812343e-05 / 6.138314516641965e-06 / 0.00047208959650121314 | 0.004372 | 6 |
| 65 | KDM1A_3 | 0.0000000105 | 0.00020172074167490282 / 6.059446073630997e-06 / 3.4966947244211546e-05 / 0.00035787841907612255 / 8.084536486163457e-05 / 0.030001525763098943 | 1.9191726349291212e-07 / 1.1031846529359998e-09 / 1.1293378746596968e-07 / 3.850331218970383e-06 / 3.0967264542843456e-07 / 4.878540657681566e-06 | 0.005114 | 6 |
| 66 | SRSF1_1 | 0.0000149516 | 0.003065043011644369 / 0.00022847309395920425 / 0.007223252257555813 / 0.002399019537670231 / 0.0023157697041580965 / 0.016498427519842422 | 1.756253200088118e-08 / 1.4552116534728694e-07 / 1.9822115797618054e-07 / 0.00022932374573720484 / 8.206690733883024e-07 / 2.2543227834379112e-07 | 0.005288 | 6 |
| 67 | WHAMM_1 | 0.0000006802 | 0.00173044075017522 / 3.679473658399758e-05 / 0.007154235078360664 / 0.0005658979552839525 / 0.022166841169996183 / 0.0008973831238703076 | 1.819882893948959e-08 / 7.796445160214981e-06 / 4.241150850168489e-05 / 2.1522400443486433e-05 / 1.3244633411180583e-06 / 3.4248686087626584e-06 | 0.005425 | 6 |
| 68 | LEPRE1_4 | 0.0000000000 | 0.0009439710790866046 / 0.0005817669851518343 / 0.001866551132439743 / 0.0064518824694126935 / 0.024010305513094434 / 0.0005799813920946167 | 5.057896230784973e-09 / 1.2435409883337575e-09 / 4.849591006599988e-07 / 2.513207633152382e-07 / 7.926212421845088e-06 / 9.994009471711418e-06 | 0.005739 | 6 |
| 69 | TRMT61B_1 | 0.0000029142 | 0.00019565429421873628 / 9.250262180987785e-07 / 6.358888418896258e-05 / 0.007843131253822322 / 0.026473307528210963 / 0.0005756579425604447 | 1.5078060373014486e-07 / 2.934542273575563e-07 / 1.2562708953802216e-08 / 5.523864073902343e-05 / 2.1559815321332083e-05 / 3.99120679034904e-07 | 0.005859 | 6 |
| 70 | KANK1_1 | 0.0000005033 | 0.00029139375190295606 / 0.009220967328515883 / 0.008770410107355643 / 0.014437131210731376 / 0.002271551295087959 / 0.004557941079021841 | 5.395125257906878e-09 / 1.5463446946793206e-07 / 9.30211963759247e-07 / 1.5254780926528496e-05 / 2.370997764208311e-05 / 3.6188491330904777e-06 | 0.006592 | 6 |
| 71 | FAM126A_1 | 0.0000010549 | 8.712601577854501e-09 / 4.778480179883678e-05 / 0.029987683740818265 / 0.0006110060061203364 / 0.0014562282237067896 / 0.010748894710017389 | 5.924782315476787e-13 / 7.1855057793508855e-09 / 5.8414503343797016e-08 / 3.0767728402054146e-07 / 3.866278498641532e-05 / 6.044718602493066e-06 | 0.007142 | 6 |
| 72 | CASKIN1_1 | 0.0000009531 | 0.0004052971561229435 / 0.004531342266561176 / 0.0026490796375761676 / 0.0030838618137353662 / 0.0016555906467057811 / 0.03955358967054088 | 6.0724511656641e-08 / 2.4239072038012358e-06 / 2.9932584561794108e-06 / 2.381049500017635e-07 / 3.5273148222341567e-07 / 8.97249895656115e-07 | 0.008646 | 6 |
| 73 | PHIP_3 | 0.0000000007 | 0.00021593310745224813 / 0.001021373946566871 / 0.000875589310570064 / 0.03219163721249994 / 0.018101605571703944 / 0.0018008865475031112 | 7.804787711336222e-10 / 7.962047079615459e-07 / 1.3767715926221406e-06 / 9.21068648623731e-07 / 2.0427438064371946e-06 / 2.061133383896347e-06 | 0.009035 | 6 |
| 74 | ISL1_1 | 0.0000011109 | 0.00029139375190295606 / 0.004557941079021841 / 7.763485144629643e-05 / 0.03147989324458417 / 0.009220967328515883 / 0.014437131210731376 | 1.0776705684350702e-07 / 9.139106854866213e-08 / 1.5262551782073314e-06 / 7.17589463363722e-05 / 1.6643398808959587e-05 / 2.7254012211130744e-05 | 0.010011 | 6 |
| 75 | FAM114A1_1 | 0.0000011740 | 0.008158453075892491 / 0.00706078944078839 / 6.392429369799613e-05 / 0.047093499348454915 / 0.0011036487237694873 / 0.0012146763275784356 | 3.9222069331739446e-09 / 1.0484859600093688e-07 / 1.1328590320930398e-08 / 1.4044847451826967e-07 / 1.6732185403869882e-06 / 2.0603621902808526e-07 | 0.010782 | 6 |
| 76 | BHLHE40_5 | 0.0000000001 | 0.0007215354754391255 / 0.0003445000837785309 / 1.9977845432945953e-05 / 0.04162183582083479 / 0.0018003544554504962 / 0.022135056393026143 | 1.9299792697031883e-08 / 5.991364646156074e-06 / 6.2842442407564126e-06 / 7.23523138723521e-05 / 4.37410397098931e-05 / 8.612084128833267e-05 | 0.011107 | 6 |
| 77 | RNH1_2 | 0.0000001050 | 0.000506059688566897 / 0.005186853257558283 / 0.012649170673498711 / 0.001227543851685287 / 0.02830343719752466 / 0.04658173961213423 | 1.9114165577673726e-07 / 1.1785627242528596e-05 / 1.1961430183679334e-05 / 5.5941363386033185e-06 / 0.0003160168984552755 / 6.436245153753663e-06 | 0.015742 | 6 |
| 78 | SLC35F5_2 | 0.0000000018 | 0.0004361351075887015 / 0.022927539814265496 / 0.04092933544326924 / 0.006547044668673556 / 0.028271710657491178 / 0.00020952110146219778 | 4.764738756551879e-09 / 4.080828723669075e-06 / 3.470949128294469e-05 / 1.4915989057385644e-06 / 3.6434591065850956e-07 / 5.290028218404434e-06 | 0.016554 | 6 |
| 79 | TRAP1_1 | 0.0000001560 | 0.0020456136275657888 / 0.002859168680149655 / 0.005851685675009941 / 0.01576374271095223 / 0.026715472976530045 / 0.04871212229027521 | 3.490113886399775e-11 / 1.4427864532484367e-07 / 6.218256736106799e-06 / 8.405023850544253e-07 / 1.4752725092614505e-05 / 0.000126359581600695 | 0.016991 | 6 |
| 80 | SLC10A3_1 | 0.0000020963 | 0.011413935706631708 / 0.017443397981769932 / 0.014660785392642973 / 0.017145541610166553 / 0.03683753470884825 / 0.010610163045225487 | 5.700211166503259e-07 / 1.392805628701067e-07 / 3.319072411206087e-06 / 4.021260874574252e-06 / 1.6786320992493728e-06 / 6.426344116619477e-06 | 0.018019 | 6 |
| 81 | IL10RB_1 | 0.0000014439 | 0.0018473350729729212 / 0.025082579510674555 / 0.015382714940475899 / 0.01903033340546255 / 0.042397669225769964 / 0.010590633670572098 | 6.305508475517821e-07 / 2.1289852323575975e-06 / 1.3929853301059418e-05 / 5.9674182467591734e-05 / 0.0005196865649666491 / 8.689281900910874e-05 | 0.019055 | 6 |
| 82 | CCDC138_3 | 0.0000000000 | 2.8507575756692187e-05 / 8.39983457440053e-08 / 5.171191093952371e-06 / 0.00013241015291548088 / 0.00013231289428074683 | 3.594844984072266e-08 / 4.1699450769671714e-10 / 1.7829184957785041e-06 / 1.6716512185751531e-07 / 6.673606916636778e-06 | 5.97E-05 | 5 |
| 83 | LDLRAP1_1 | 0.0000008179 | 0.00011095297992729127 / 5.264359468000088e-05 / 0.0011242387519002353 / 4.668223816223458e-05 / 1.2920956774321015e-06 | 7.024419920758419e-08 / 3.7947570137300835e-07 / 1.3563326532912054e-07 / 8.17408329321785e-05 / 8.828337775002166e-05 | 0.000267 | 5 |
| 84 | SH3BGRL3_3 | 0.0000000001 | 4.2473135511991315e-05 / 0.00018110968427817472 / 2.3012675922598175e-05 / 0.0012229341595829208 / 7.876891018158643e-05 | 6.991877310539878e-06 / 9.480200177754412e-06 / 0.00015579668074547338 / 1.8811555342370173e-05 / 6.910060016993254e-06 | 0.00031 | 5 |
| 85 | RARRES3_3 | 0.0000000000 | 5.445858436353469e-05 / 0.0009962374983153238 / 0.00039011483425120365 / 0.00012136000976514409 / 3.791878524439541e-05 | 1.56194833594799e-09 / 1.296245999203945e-06 / 1.1756173797034747e-06 / 1.527843952821709e-05 / 5.848148683004699e-07 | 0.00032 | 5 |
| 86 | ANXA4_4 | 0.0000000000 | 1.363288691355937e-06 / 1.5143046244596162e-05 / 5.189840282140393e-05 / 5.782599824929034e-05 / 0.001524236220832947 | 1.0031685363992852e-08 / 6.841456697948725e-09 / 1.9180526546377784e-06 / 8.794172382219916e-06 / 2.953468988272718e-06 | 0.00033 | 5 |
| 87 | LYST_1 | 0.0000027714 | 0.0014431024451110606 / 5.264359468000088e-05 / 0.00011095297992729127 / 0.00020173841888508878 / 6.995348463708383e-05 | 1.1240472731245707e-08 / 2.350080008352624e-06 / 1.1075551169706485e-06 / 1.7042664405713885e-06 / 4.2116046384684526e-05 | 0.000376 | 5 |
| 88 | MR1_4 | 0.0000000000 | 7.715095979792449e-07 / 0.001693666645875025 / 6.395023692800854e-05 / 0.00031256159798863684 / 3.9188876899229826e-06 | 1.1557582761220409e-08 / 5.677180579700876e-06 / 2.8754646285556484e-06 / 5.64979021764616e-07 / 1.8797358227572578e-05 | 0.000415 | 5 |
| 89 | SELRC1_1 | 0.0000005524 | 0.00037839447623271325 / 0.00042879723237597764 / 0.001443320215490813 / 0.0004410378323337517 / 0.00010681753824403367 | 1.2864802377615588e-11 / 2.1196501777135548e-08 / 1.3367474421932726e-09 / 7.5658631683473564e-06 / 5.602327158926525e-08 | 0.00056 | 5 |
| 90 | LDHB_5 | 0.0000000000 | 2.9413591946334052e-06 / 0.00018071660821354673 / 1.726070100137361e-05 / 0.0006331647449173639 / 0.0029940534519961185 | 2.3674403554451728e-09 / 1.5213269839159292e-06 / 4.075392395353731e-07 / 1.8533263086532664e-06 / 6.582873587671421e-05 | 0.000766 | 5 |
| 91 | GBE1_2 | 0.0000000003 | 0.0033273695719493366 / 2.1541055929197527e-08 / 1.9308695609987287e-05 / 0.0003451393798156882 / 0.00038134035343875063 | 5.906459505383357e-08 / 2.4094693488118412e-09 / 1.0620489017054289e-07 / 6.750639833651121e-07 / 1.8752484455808676e-05 | 0.000815 | 5 |
| 92 | PTRF_2 | 0.0000000003 | 0.0033273695719493366 / 2.1541055929197527e-08 / 0.0003451393798156882 / 1.9308695609987287e-05 / 0.00038134035343875063 | 4.017261878814523e-08 / 7.146428295045248e-09 / 6.101976957550238e-07 / 2.1688184575439267e-06 / 6.686443921029525e-06 | 0.000815 | 5 |
| 93 | SQSTM1_3 | 0.0000000000 | 3.9761649107081705e-05 / 0.0016006026930324019 / 0.0008611052684263142 / 0.0012009850065108874 / 0.0006237640708459632 | 4.01947151989452e-07 / 1.339226375307952e-06 / 1.754090841474079e-06 / 7.055430531026282e-07 / 2.6767693410519625e-06 | 0.000865 | 5 |
| 94 | PA2G4_1 | 0.0000000017 | 0.001443320215490813 / 0.00037839447623271325 / 0.00042879723237597764 / 0.003993715376548959 / 0.00028286232014178015 | 3.045245115555592e-10 / 1.8399976601880802e-08 / 5.830030485334704e-07 / 9.508100999171547e-06 / 1.13769352855429e-05 | 0.001305 | 5 |
| 95 | GBP3_2 | 0.0000000003 | 0.0005839379621670203 / 1.3428726435262393e-05 / 0.005991852836482861 / 0.0001081781120537704 / 2.8744610334651343e-06 | 4.819954330621288e-08 / 6.412523041836917e-07 / 2.8569657952677404e-06 / 2.0985004888144685e-05 / 2.3525509311119436e-06 | 0.00134 | 5 |
| 96 | CHD7_2 | 0.0000000001 | 0.0018350968591216627 / 7.477363698097769e-05 / 0.00015975427450238799 / 0.00391277170211791 / 0.0008685464813169234 | 1.0531573829941702e-07 / 7.878415280920932e-08 / 1.1141611641319887e-07 / 5.1757956178869716e-06 / 8.934190321293886e-06 | 0.00137 | 5 |
| 97 | ELF4_4 | 0.0000000000 | 1.5042859087051511e-05 / 0.0015054443180049152 / 0.0035324162802343384 / 0.0015681053781698034 / 0.00044306616234558656 | 1.0129117193066866e-07 / 3.803422404924242e-08 / 3.196969576173562e-05 / 2.0994506448972058e-06 / 8.674339153748824e-06 | 0.001413 | 5 |
| 98 | HEXB_2 | 0.0000000027 | 0.0001364689621921479 / 0.0017139782149577006 / 0.00042251637580553855 / 0.004506824346577342 / 0.0011693468213267385 | 5.600402893224147e-07 / 1.7114753018966675e-06 / 7.859127616630422e-06 / 2.136847848300081e-06 / 1.057919545610576e-06 | 0.00159 | 5 |
| 99 | TGOLN2_3 | 0.0000000000 | 0.002887936541355392 / 0.0012489133459296009 / 3.971802768150102e-09 / 5.351370414635355e-06 / 0.004542992850202789 | 1.5278667902264538e-08 / 6.147579495364705e-07 / 2.55317658003628e-07 / 9.866879372887889e-08 / 6.124699763744859e-06 | 0.001737 | 5 |
| 100 | CBR3_5 | 0.0000000000 | 1.7429615872247697e-06 / 2.1772701241259695e-05 / 4.265116466854638e-05 / 0.0006691661140725223 / 0.009174735989250154 | 1.7321244665799745e-08 / 1.9865066542844766e-06 / 6.139861852092745e-07 / 3.5205839483278234e-06 / 4.046680434424515e-05 | 0.001982 | 5 |
| 101 | C14orf93_1 | 0.0000000417 | 0.005409509534570436 / 0.0014863302195178008 / 0.002391299161389133 / 0.0006273187563236247 / 1.384655004104117e-06 | 7.500915749450172e-10 / 3.167346841801568e-06 / 6.173059623938025e-07 / 7.496583765477882e-06 / 2.018269137344719e-06 | 0.001983 | 5 |
| 102 | ACVR1B_5 | 0.0000000000 | 0.0011897273750790794 / 4.043863569216427e-06 / 0.003135726107000613 / 1.2302005748125012e-06 / 0.005979891210353361 | 8.795727468366677e-07 / 1.740359378085258e-08 / 3.922859794878605e-06 / 5.715287595383605e-07 / 3.0426357547305182e-05 | 0.002062 | 5 |
| 103 | WNK2_1 | 0.0000008965 | 0.004531342266561176 / 0.0004052971561229435 / 0.0026490796375761676 / 0.0016555906467057811 / 0.0030838618137353662 | 5.735186182795572e-07 / 4.097215580173646e-09 / 2.1966688549867895e-05 / 7.38514634627583e-06 / 9.495710202696889e-06 | 0.002465 | 5 |
| 104 | GBE1_5 | 0.0000000000 | 3.826852437313171e-06 / 0.0010708658291423757 / 0.00019953068534511048 / 0.009169711616283972 / 0.0026316110463780696 | 9.044891469948086e-09 / 3.7048735780400227e-07 / 2.359441941877069e-06 / 1.5764817932193767e-05 / 2.274686348690355e-05 | 0.002615 | 5 |
| 105 | RAB27A_2 | 0.0000000000 | 7.635253341668868e-05 / 0.005021656852415849 / 3.5215907075366917e-06 / 0.00034267788827357215 / 0.007895113233237851 | 1.914896020510999e-07 / 9.517291296985127e-08 / 7.969576900636687e-08 / 5.846288233066031e-08 / 4.5361993939378207e-07 | 0.002668 | 5 |
| 106 | FAP_3 | 0.0000000006 | 0.0019684942173753836 / 0.0009928703588443979 / 0.0005051149609558843 / 0.00011232928113623314 / 0.012918030852908461 | 1.2766883170125572e-07 / 2.4021041707717316e-06 / 1.0836840144491595e-06 / 8.446479999419288e-06 / 3.6833375749558764e-06 | 0.003299 | 5 |
| 107 | THBS1_1 | 0.0000000712 | 0.0019027179320774803 / 0.004613449756294485 / 0.0003168019030192227 / 0.0012733956455115425 / 0.010654255097368902 | 2.1096989696063183e-09 / 2.8418823932552776e-08 / 2.9577603926263325e-08 / 1.6345742810026593e-05 / 7.1941049967859985e-06 | 0.003752 | 5 |
| 108 | RNF44_2 | 0.0000000001 | 0.0007973635551597535 / 7.563774009011881e-05 / 0.01008336409450162 / 0.004045539400699223 / 0.004865413756574913 | 5.271414210724663e-11 / 3.736942531550046e-07 / 2.3747819656119838e-08 / 1.893540361128054e-06 / 1.2212684566221971e-06 | 0.003973 | 5 |
| 109 | C2orf44_4 | 0.0000000014 | 1.0808929306666273e-05 / 0.008934208121620274 / 0.00010039306136116464 / 0.009784265308543377 / 0.0024009587334497774 | 1.2187744602716387e-10 / 1.9588399373708684e-06 / 4.6145010226590306e-07 / 3.855402108931244e-05 / 2.3663313142656787e-05 | 0.004246 | 5 |
| 110 | ZSCAN2_1 | 0.0000003244 | 0.005494404451518434 / 0.002117501407135496 / 0.015063580358728427 / 0.00406276527468287 / 0.00029389877591584477 | 4.440150276665828e-06 / 1.6041254678652375e-05 / 6.101223267687242e-06 / 1.4917171986665666e-06 / 1.8918665259353665e-05 | 0.005406 | 5 |
| 111 | PSMB8_3 | 0.0000000001 | 1.1139371348435439e-05 / 0.000295206951604009 / 0.0011420234721703612 / 0.004002189263586216 / 0.022007285373854 | 3.18097586113718e-08 / 8.739864511743991e-07 / 1.4187996767508308e-05 / 1.4206186275488269e-05 / 2.1536287095072426e-06 | 0.005492 | 5 |
| 112 | CTGF_2 | 0.0000000009 | 0.00015265799477510392 / 0.004284835035004821 / 0.005655033062620194 / 0.017812704981803436 / 0.00018190158542752172 | 5.263266054115357e-07 / 4.3695038068811766e-08 / 3.7740283990797325e-06 / 7.135038004681359e-07 / 2.643168822853883e-05 | 0.005617 | 5 |
| 113 | DAP_1 | 0.0000000596 | 0.008158453075892491 / 6.392429369799613e-05 / 0.01165101001080378 / 0.00706078944078839 / 0.0012146763275784356 | 1.4736850125189888e-07 / 3.908902039015359e-08 / 1.7628401584823726e-07 / 1.5347002454072624e-05 / 1.7507947709175734e-05 | 0.00563 | 5 |
| 114 | PHOX2A_1 | 0.0000003175 | 0.008158453075892491 / 6.392429369799613e-05 / 0.00706078944078839 / 0.01165101001080378 / 0.0012146763275784356 | 5.8181933193632506e-08 / 1.1078332486685944e-07 / 1.2847626080278513e-05 / 1.9169572452878826e-06 / 1.3210118079992226e-05 | 0.00563 | 5 |
| 115 | MVP_2 | 0.0000000015 | 0.0003074328712443293 / 0.029215443986862575 / 9.407443780393908e-05 / 0.0007597570913260385 / 4.843098209783887e-05 | 4.002114425736759e-08 / 1.6803136761019638e-06 / 3.376253203984945e-08 / 1.008528085216226e-05 / 4.819827094154422e-06 | 0.006085 | 5 |
| 116 | CCNJ_2 | 0.0000000010 | 0.005156889617706872 / 0.0037116981070019926 / 0.018339330602739977 / 0.0005410238034488199 / 0.0029241900112892644 | 1.3384145050432693e-05 / 1.2259034650488922e-06 / 2.418247349561274e-06 / 5.022621230368505e-05 / 3.457954174876677e-05 | 0.006135 | 5 |
| 117 | MAP4_5 | 0.0000000001 | 0.0005031786684884779 / 0.010922608465190551 / 0.018146216162979706 / 0.0003254856473440077 / 0.001272088116869848 | 2.587716794178391e-07 / 3.798173592497599e-08 / 2.5392647842825153e-06 / 4.942693897536645e-07 / 9.527740137246758e-08 | 0.006234 | 5 |
| 118 | ATP5B_2 | 0.0000000014 | 1.0473941865935008e-05 / 0.00047787043862318663 / 0.02960215538361295 / 0.001031466405675943 / 0.00013666281877242411 | 7.117260294468996e-09 / 6.152782689367921e-07 / 1.526236991383182e-05 / 1.8976244710357432e-05 / 2.5507040748716144e-06 | 0.006252 | 5 |
| 119 | TRAM2_3 | 0.0000000000 | 7.050716055970537e-06 / 0.0001057656674813077 / 0.0025449721290128477 / 6.997404830789269e-07 / 0.03280415443708167 | 5.729353647005044e-08 / 1.910962326072629e-07 / 8.344215866087099e-06 / 4.014110177183549e-06 / 1.7722857190857362e-05 | 0.007093 | 5 |
| 120 | CCDC107_5 | 0.0000000004 | 7.799742935751802e-05 / 0.023152072094571645 / 0.014505125297696268 / 0.00010031692846422633 / 0.00039456234783499816 | 2.5979973718838742e-08 / 5.275125038891406e-07 / 1.2574262998000307e-06 / 4.826438486358518e-06 / 3.332582738649872e-06 | 0.007646 | 5 |
| 121 | SMARCAD1_5 | 0.0000000000 | 6.51572554597248e-05 / 1.121807735413933e-05 / 0.0009794106383235514 / 0.028651749233987035 / 0.016373864330489554 | 4.951274541156556e-07 / 4.932698411729371e-06 / 3.7416170837321407e-06 / 2.232387301624823e-06 / 6.909674555415473e-07 | 0.009216 | 5 |
| 122 | HRH1_1 | 0.0000009062 | 0.007112363650923645 / 0.007730255820425719 / 0.02421022399736038 / 0.001383098528892269 / 0.006385380233425884 | 8.024725118266073e-09 / 1.3814036761412276e-07 / 2.07690167148044e-06 / 1.4044796518330034e-05 / 1.4197658969421668e-05 | 0.009364 | 5 |
| 123 | KHDRBS1_2 | 0.0000000015 | 1.6169392314406466e-05 / 0.0039056626487888758 / 0.0034273259551571168 / 0.03391386466641536 / 0.011666948417914267 | 9.514267607742899e-13 / 2.8566604252327994e-07 / 7.517707711246514e-07 / 4.1751581964055053e-07 / 9.055789447982931e-07 | 0.010586 | 5 |
| 124 | E2F6_3 | 0.0000002841 | 0.0022254132117215356 / 0.0037188790361072878 / 0.005458005465302464 / 0.0014398907128301208 / 0.04086571019880003 | 4.421453475946776e-08 / 1.5392585786553033e-06 / 0.0003430693964816855 / 1.779882292403961e-06 / 0.0002956989113369879 | 0.010742 | 5 |
| 125 | ELL2_2 | 0.0000000202 | 0.00011694820055399171 / 0.029386513254453968 / 0.005657975920541809 / 0.028459156083205858 / 0.01406740315871594 | 8.347517785439741e-08 / 1.2698717079911781e-06 / 1.917338652438103e-05 / 0.0001196727478086908 / 2.0681105855800244e-05 | 0.015538 | 5 |
| 126 | BSN_2 | 0.0000022389 | 0.000506059688566897 / 0.04616500613759174 / 0.012649170673498711 / 0.005186853257558283 / 0.02830343719752466 | 5.0173732858781275e-06 / 1.1005994245083331e-07 / 0.00024710770557642556 / 0.00048732984216352446 / 0.00023929723037045147 | 0.018562 | 5 |
| 127 | ATG4A_5 | 0.0000000000 | 4.475035366083391e-06 / 9.946560976238241e-06 / 1.150460981566587e-06 / 6.699525372343991e-05 | 2.070885361738112e-08 / 3.791151058200872e-07 / 2.8872435045296478e-08 / 0.00012711434042399471 | 2.06E-05 | 4 |
| 128 | CD44_4 | 0.0000000000 | 4.4784520790283526e-08 / 2.3008815242152554e-05 / 5.2052109653188956e-05 / 0.00014533006515361492 | 7.884191479096678e-08 / 2.9710643899587148e-06 / 1.5781437020851443e-06 / 6.210975626614534e-07 | 5.51E-05 | 4 |
| 129 | GSN_5 | 0.0000000000 | 3.785922406236843e-10 / 3.0058719101012673e-05 / 0.00029646205587575313 / 6.646730266541163e-05 | 8.816984894077637e-10 / 2.2588865060721033e-06 / 7.88507208198445e-05 / 4.284376587003957e-05 | 9.82E-05 | 4 |
| 130 | CD99_5 | 0.0000000000 | 2.0149183113126577e-05 / 0.0006745061120899554 / 0.0002998852328395526 / 0.0001242923271196099 | 3.1338403532472386e-09 / 0.0006507487844929586 / 5.172267401380639e-06 / 9.968659271858592e-06 | 0.00028 | 4 |
| 131 | GNAI2_5 | 0.0000000000 | 0.0005584151279765244 / 0.0003249499378752368 / 4.745051251091654e-05 / 0.00030759784724731154 | 4.982873808104418e-08 / 9.650800047119655e-07 / 2.454295952727384e-07 / 9.904904324446315e-05 | 0.00031 | 4 |
| 132 | DDX60_5 | 0.0000000000 | 2.9212913515461393e-06 / 0.0001530409063220267 / 0.0003993610031162385 / 0.0010695426477561165 | 7.01839699594606e-08 / 2.0329686030779097e-06 / 1.4613415440657328e-05 / 1.702607599935211e-05 | 0.000406 | 4 |
| 133 | MICALL2_3 | 0.0000000000 | 4.697595022472674e-06 / 6.457501817223296e-05 / 0.0015363886875154054 / 0.00014385763146450997 | 1.7875525723925519e-06 / 1.642694121565277e-07 / 1.8052618402003836e-05 / 5.8265193908577595e-05 | 0.000437 | 4 |
| 134 | SOAT1_5 | 0.0000000000 | 0.001922385896174513 / 1.924383271682602e-06 / 2.782774586423633e-06 / 3.555527535100237e-05 | 7.936734231102217e-07 / 6.625132467195288e-08 / 5.379303522414254e-07 / 2.3383986457320025e-06 | 0.000491 | 4 |
| 135 | PLEC_1 | 0.0000008789 | 4.778480179883678e-05 / 0.0006110060061203364 / 8.712601577854501e-09 / 0.0014562282237067896 | 2.8277390114780423e-07 / 2.166203983124237e-06 / 1.5583735231329512e-07 / 2.7125361005219603e-06 | 0.000529 | 4 |
| 136 | XRCC5_1 | 0.0000000924 | 1.384655004104117e-06 / 0.0006273187563236247 / 2.098169823270148e-06 / 0.0014863302195178008 | 2.6130050369275158e-06 / 2.132206160555519e-05 / 2.4237849248550327e-06 / 0.00030699349223093454 | 0.000529 | 4 |
| 137 | OSGEPL1_1 | 0.0000001116 | 0.00028286232014178015 / 0.00037839447623271325 / 0.001443320215490813 / 0.00010681753824403367 | 3.604572142413008e-06 / 4.082064229081972e-06 / 3.18593215315723e-06 / 9.670676646757636e-07 | 0.000553 | 4 |
| 138 | TMEM97_4 | 0.0000000000 | 0.00018650020835883543 / 0.0004347886633272347 / 4.502684569031259e-06 / 0.0016700457783649062 | 3.3084881992489725e-06 / 4.754536166762309e-06 / 1.3093900089996567e-06 / 5.225302868715506e-05 | 0.000574 | 4 |
| 139 | GLIS3_4 | 0.0000000000 | 0.0002286645360176498 / 0.0006619438558324503 / 0.0016620049728346326 / 1.1074671736457553e-05 | 1.510316419391924e-06 / 3.2409409252278102e-06 / 9.224875739627753e-05 / 1.930014755272634e-05 | 0.000641 | 4 |
| 140 | ANXA1_5 | 0.0000000000 | 5.8551591866382045e-05 / 3.45022524746413e-05 / 6.004993403577111e-08 / 0.002751213558972749 | 2.397154304313467e-07 / 3.176106815413732e-06 / 6.107114335334353e-07 / 1.2210016577494943e-05 | 0.000711 | 4 |
| 141 | FAM120A_5 | 0.0000000001 | 0.0026813412993839337 / 0.0005742956528301279 / 3.563997625540032e-05 / 8.528922868820983e-06 | 0.0001881828357253321 / 0.00012537124618201126 / 1.3817216627076195e-05 / 0.00011563779547673361 | 0.000825 | 4 |
| 142 | SAFB_3 | 0.0000000001 | 0.001211277784043611 / 0.00011818878635236698 / 0.00029246473195964197 / 0.001769841813108865 | 7.668444452032125e-07 / 2.898461734945786e-07 / 2.8130419096127126e-05 / 0.00035040496082839104 | 0.000848 | 4 |
| 143 | ACTN4_4 | 0.0000000000 | 1.4106395746220967e-05 / 8.221349715218104e-05 / 0.003449453406084509 / 0.0001267717634392765 | 3.3938237122738275e-07 / 1.2062404978268685e-06 / 4.0239968184075355e-06 / 2.990385220556594e-05 | 0.000918 | 4 |
| 144 | FAM117B_5 | 0.0000000000 | 0.00014565693019513351 / 0.0006387724048262495 / 2.041989162397474e-07 / 0.00308065083431233 | 1.2462660948443544e-05 / 4.0378352806812125e-06 / 4.5557593081500904e-08 / 6.255861262356289e-05 | 0.000966 | 4 |
| 145 | TSSC1_1 | 0.0000008042 | 0.0010281262291342236 / 0.0008973831238703076 / 0.0014311836039126026 / 0.0005658979552839525 | 4.773040777006663e-07 / 1.293648273273451e-06 / 1.370737279606987e-06 / 6.872239294614834e-08 | 0.000981 | 4 |
| 146 | SERPINE2_1 | 0.0000006237 | 8.712601577854501e-09 / 0.003917317274808632 / 4.778480179883678e-05 / 0.0006110060061203364 | 4.293656906359287e-09 / 7.59699887090359e-07 / 2.4805326670497096e-06 / 2.6318189672753774e-06 | 0.001144 | 4 |
| 147 | IFNAR1_5 | 0.0000000000 | 1.6950082284852724e-05 / 0.00023259440421303834 / 2.145061357704084e-05 / 0.006168307042686711 | 2.6777259205549025e-06 / 3.126328063081149e-07 / 1.6378968792487728e-05 / 1.980502151445686e-05 | 0.00161 | 4 |
| 148 | UEVLD_3 | 0.0000000002 | 0.0025817513756711884 / 0.0002058200859707558 / 0.0001532402705811572 / 0.003951386408683102 | 1.7719417389393089e-06 / 1.5327037128336517e-08 / 5.132415043139141e-08 / 8.649188479247404e-07 | 0.001723 | 4 |
| 149 | GUF1_5 | 0.0000000000 | 5.893107805476978e-05 / 0.007964457709027949 / 4.303196745477378e-05 / 2.6967345038980607e-05 | 3.970170459579241e-07 / 2.864249504984967e-06 / 3.435012765675232e-07 / 1.5389318932784949e-06 | 0.002023 | 4 |
| 150 | GBP3_1 | 0.0000015823 | 0.0019027179320774803 / 0.0003168019030192227 / 0.004613449756294485 / 0.0012733956455115425 | 1.8104358020946005e-07 / 2.2473742888087726e-07 / 3.977899627306711e-05 / 5.118490443586335e-06 | 0.002027 | 4 |
| 151 | MED28_1 | 0.0000032077 | 0.0003168019030192227 / 0.0019027179320774803 / 0.004613449756294485 / 0.0012733956455115425 | 2.9684923703899697e-07 / 6.654843522911474e-07 / 3.1176140675136144e-06 / 3.225376490885068e-06 | 0.002027 | 4 |
| 152 | SLC2A10_1 | 0.0000000972 | 0.0019027179320774803 / 0.0003168019030192227 / 0.004613449756294485 / 0.0012733956455115425 | 1.7631746614895863e-07 / 2.4782620652363583e-09 / 6.763392837610305e-07 / 2.321466389902454e-06 | 0.002027 | 4 |
| 153 | CBR3_1 | 0.0000000238 | 0.0003168019030192227 / 0.0012733956455115425 / 0.0019027179320774803 / 0.004613449756294485 | 7.910872738545078e-09 / 1.4202365174097019e-08 / 5.43796956141398e-07 / 4.674686520121403e-05 | 0.002027 | 4 |
| 154 | HIC2_1 | 0.0000007789 | 0.0019027179320774803 / 0.0012733956455115425 / 0.004613449756294485 / 0.0003168019030192227 | 3.0633550655698566e-10 / 2.1696779182322382e-09 / 2.2828231685954628e-07 / 2.4650085263362296e-06 | 0.002027 | 4 |
| 155 | IGSF9_1 | 0.0000004185 | 0.0012733956455115425 / 0.0003168019030192227 / 0.004613449756294485 / 0.0019027179320774803 | 3.3765982883653153e-06 / 2.559009185958782e-07 / 1.2961469049521693e-06 / 8.135407791689286e-05 | 0.002027 | 4 |
| 156 | RCAN1_1 | 0.0000010839 | 0.0019027179320774803 / 0.004613449756294485 / 0.0012733956455115425 / 0.0003168019030192227 | 3.52499926166527e-09 / 1.4195702150916024e-07 / 2.8012155247278448e-06 / 8.591081719368746e-08 | 0.002027 | 4 |
| 157 | SAFB_1 | 0.0000022906 | 0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227 / 0.0012733956455115425 | 1.2527049345521191e-06 / 1.2341574556015853e-07 / 4.073201704051311e-08 / 5.976596803731563e-06 | 0.002027 | 4 |
| 158 | HNRNPA0_2 | 0.0000000370 | 0.0009389452362024158 / 0.0004583304262309702 / 2.0318525623421967e-06 / 0.006886174737452949 | 6.591983136046331e-08 / 2.1078089903628105e-05 / 2.1991513327880328e-05 / 6.211957230218145e-05 | 0.002071 | 4 |
| 159 | ISL1_1 | 0.0000000008 | 0.0014562282237067896 / 8.712601577854501e-09 / 4.778480179883678e-05 / 0.008799197542964286 | 4.47926130890511e-10 / 1.3159792563051542e-10 / 1.6267903098803325e-06 / 8.859331058014511e-06 | 0.002576 | 4 |
| 160 | PPIC_1 | 0.0000008150 | 1.1499890891595663e-06 / 0.0023486428669150803 / 0.004509729888699788 / 0.003649857824379229 | 6.181851966897516e-08 / 4.336126091570401e-07 / 1.130291682742051e-06 / 5.702819528263402e-06 | 0.002627 | 4 |
| 161 | CBX1_1 | 0.0000073072 | 0.00920357999307954 / 0.00020520490391129044 / 0.0014863302195178008 / 2.098169823270148e-06 | 3.4308469313672e-05 / 0.00016072496067379242 / 0.000416531131321131 / 1.1909250396666738e-05 | 0.002724 | 4 |
| 162 | ARID3B_1 | 0.0000039314 | 0.0012733956455115425 / 0.0019027179320774803 / 0.004613449756294485 / 0.0034947768260440494 | 5.689363226662423e-09 / 3.5223565854980375e-06 / 2.7692513603614087e-06 / 7.767239795505205e-06 | 0.002821 | 4 |
| 163 | RNF157_1 | 0.0000017210 | 0.004531342266561176 / 0.0026490796375761676 / 0.0016555906467057811 / 0.0030838618137353662 | 1.0799957008656176e-05 / 7.097149358472166e-05 / 4.819541314832769e-07 / 7.676415694714317e-07 | 0.00298 | 4 |
| 164 | EIF3L_2 | 0.0000000102 | 0.005135657485519335 / 0.005326745976664332 / 0.0017435819308224765 / 7.384136449790188e-06 | 1.8190521073639574e-10 / 1.0527503241568249e-06 / 4.518548487460203e-06 / 1.3638553131166296e-06 | 0.003053 | 4 |
| 165 | SLC25A43_2 | 0.0000000002 | 0.00014847770954858836 / 0.0010357469368733494 / 0.0010144217502109298 / 0.010259629272911746 | 3.357035874085631e-07 / 7.382332140811268e-07 / 2.131827740313582e-06 / 3.004944425021926e-05 | 0.003115 | 4 |
| 166 | OLFML2A_1 | 0.0000000021 | 0.0014562282237067896 / 8.712601577854501e-09 / 0.0006110060061203364 / 0.010748894710017389 | 1.2437444351849456e-10 / 1.877118300185312e-10 / 1.270455283512457e-06 / 1.2117974236888312e-06 | 0.003204 | 4 |
| 167 | HNRNPA1L2_4 | 0.0000000000 | 3.055750323559003e-05 / 0.013700253988565498 / 3.881898534012908e-05 / 4.532481843678641e-08 | 9.763383363669304e-09 / 6.413557230739407e-06 / 1.1996173334605904e-08 / 2.6326526346171393e-08 | 0.003442 | 4 |
| 168 | GPR125_1 | 0.0000015939 | 0.0004338260851758113 / 0.005078710464709388 / 0.005770181686062503 / 0.0025299472548494955 | 8.375396341394661e-06 / 1.2620826876929007e-07 / 5.037605201133463e-06 / 4.397437068329601e-06 | 0.003453 | 4 |
| 169 | HFM1_5 | 0.0000000000 | 4.6027629362357145e-06 / 2.054289713438471e-06 / 0.010747113861164049 / 0.0030735298911349954 | 5.2804634950801046e-08 / 1.3823733955490087e-07 / 0.0002289318652341564 / 0.00017922188693161184 | 0.003457 | 4 |
| 170 | FAM161A_3 | 0.0000000004 | 1.1900765556084342e-06 / 6.104336159313168e-05 / 0.0038692378656813085 / 0.010450418229319037 | 7.836775108119704e-06 / 4.602994442160525e-06 / 0.0014084623238924201 / 0.006437120167388166 | 0.003595 | 4 |
| 171 | MYO1E_5 | 0.0000000000 | 9.1301369378943e-07 / 3.6970513366191076e-05 / 0.014560624799721568 / 0.00044473645621912025 | 1.563633164899415e-07 / 6.6703997984050774e-06 / 0.0002544952895081012 / 1.2369712374983664e-06 | 0.003761 | 4 |
| 172 | BHLHE40_2 | 0.0000000008 | 0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 / 0.012364148039779468 | 3.6750231825447993e-09 / 1.3797224307526888e-10 / 4.5238117998428525e-10 / 1.4503164618207844e-05 | 0.004009 | 4 |
| 173 | IPO9_1 | 0.0000001864 | 0.00706078944078839 / 6.392429369799613e-05 / 0.0011036487237694873 / 0.008158453075892491 | 7.925030915673659e-07 / 2.436316843178784e-07 / 2.7933385967164893e-06 / 3.7162081746516914e-06 | 0.004097 | 4 |
| 174 | MALT1_5 | 0.0000000000 | 8.286399528571891e-06 / 0.0002461865995006486 / 0.00023833137981344143 / 0.016843325771737905 | 3.375997586023991e-08 / 1.2071446047409586e-07 / 1.095602481975961e-06 / 2.6082135535498982e-06 | 0.004334 | 4 |
| 175 | GDPD1_1 | 0.0000033642 | 0.008597087236259153 / 0.002859168680149655 / 0.0007069744136606002 / 0.005851685675009941 | 9.233213274811235e-08 / 3.5536116052273754e-07 / 2.1037456632604637e-07 / 1.3670539309103289e-05 | 0.004504 | 4 |
| 176 | CLIC1_5 | 0.0000000000 | 0.00048798421080350877 / 0.003091093830161087 / 0.005843494432330533 / 0.008851783624153233 | 3.133239901460721e-08 / 1.3305262196278536e-08 / 4.3396495831301414e-05 / 1.8259140204877226e-06 | 0.004569 | 4 |
| 177 | GBP1_1 | 0.0000000190 | 0.00029139375190295606 / 0.008770410107355643 / 0.009220967328515883 / 7.763485144629643e-05 | 2.034005959874992e-08 / 1.025777265986079e-05 / 3.7717113262051256e-06 / 6.322665753334008e-05 | 0.00459 | 4 |
| 178 | WDR1_4 | 0.0000000063 | 0.00018307154229595032 / 0.0002457066480750095 / 0.0005563718559501817 / 0.01757082718712336 | 1.4158768736111935e-07 / 1.8926145330443176e-07 / 3.145940065328651e-05 / 2.00918389447038e-06 | 0.004639 | 4 |
| 179 | NOLC1_1 | 0.0000002124 | 0.005497026258977277 / 0.0037411319458859455 / 0.001569082671062799 / 0.009893561180811163 | 1.0104488773237543e-08 / 7.714332997539589e-07 / 2.1884817904926247e-06 / 3.370149988961001e-05 | 0.005175 | 4 |
| 180 | SUCLG2_1 | 0.0000002256 | 0.0008973831238703076 / 0.0060047412034100744 / 0.013949817553702996 / 3.679473658399758e-05 | 4.6445581997855444e-07 / 0.00013589105082118295 / 6.517922811200161e-07 / 3.2332580875235436e-06 | 0.005222 | 4 |
| 181 | TMEM50B_4 | 0.0000000000 | 0.00021033920160836247 / 3.048709751971941e-06 / 7.4963019248993875e-06 / 0.02190343894897618 | 4.260473533327541e-07 / 3.0953447432169544e-06 / 1.0406702632518272e-05 / 6.714065008670566e-05 | 0.005531 | 4 |
| 182 | TEP1_2 | 0.0000000008 | 0.00044390649641880996 / 0.00022291138567452008 / 0.007728913610011587 / 0.013802397731305673 | 7.69344257098905e-08 / 7.583371932539051e-07 / 1.1452916356973667e-05 / 1.4951877455973638e-05 | 0.00555 | 4 |
| 183 | C1QTNF4_1 | 0.0000065502 | 0.018168011703420802 / 0.0008739549079227278 / 0.0021525218115003323 / 0.001823497355076137 | 1.4609518924208137e-05 / 1.9886833860209337e-08 / 3.327674138498291e-05 / 4.1425752762924387e-07 | 0.005754 | 4 |
| 184 | SAMD9_2 | 0.0000000241 | 0.00015888299030502074 / 0.0005649656249134306 / 0.02294011174111297 / 2.9781970809395596e-05 | 1.4515338714501776e-07 / 1.0069662929413845e-06 / 3.079017964078163e-05 / 2.9239260560336778e-06 | 0.005923 | 4 |
| 185 | INTS2_1 | 0.0000015748 | 0.0071423807687498436 / 0.005409509534570436 / 0.012055857526605073 / 1.7711409436331332e-05 | 3.636941582614834e-06 / 8.403767627067496e-07 / 0.000275721623498196 / 3.367956926486663e-05 | 0.006156 | 4 |
| 186 | FUBP1_1 | 0.0000511078 | 0.00130787641161479 / 0.004251874133389083 / 0.003364552119188696 / 0.015851508245258043 | 1.9108608392104508e-07 / 2.9841202780652124e-07 / 5.350933661523097e-06 / 2.1932160234548787e-07 | 0.006194 | 4 |
| 187 | RPAP1_1 | 0.0000410735 | 0.02301236512624726 / 0.0005345944155461007 / 0.001243129263120806 / 0.00047465333000177624 | 3.176104797820964e-07 / 2.5190175338691726e-06 / 2.1523203092437045e-06 / 9.149396149972693e-07 | 0.006316 | 4 |
| 188 | HEXB_1 | 0.0000076128 | 0.015529327313804105 / 0.0013546126949011356 / 0.0060782790336966815 / 0.0035812987621354486 | 6.42491318793146e-10 / 4.577473133930505e-08 / 3.39530943939453e-09 / 2.7122303773993426e-06 | 0.006636 | 4 |
| 189 | HNRNPU_1 | 0.0000032015 | 3.772462305351297e-05 / 0.00064922210107833 / 0.0010438255846085224 / 0.026018704719089503 | 1.000463952367771e-07 / 2.638911239632533e-07 / 7.660492345043258e-07 / 4.407301801134979e-06 | 0.006937 | 4 |
| 190 | FUCA1_2 | 0.0000000004 | 7.228979888741317e-05 / 0.013714832441879614 / 0.007971606520234983 / 0.007402461335311882 | 2.0988769570938153e-06 / 1.9872137311126255e-06 / 3.537000242989197e-06 / 9.575754350455543e-05 | 0.00729 | 4 |
| 191 | NOTCH2_2 | 0.0000000072 | 0.006230846374778002 / 0.003851986494620127 / 0.0034437522016521897 / 0.015866838196212218 | 1.4454100512704434e-07 / 8.519702743163462e-07 / 9.796096746463353e-06 / 3.089459803795722e-05 | 0.007348 | 4 |
| 192 | CCT4_1 | 0.0000020961 | 0.0004974933526793384 / 0.008397433522606995 / 0.008173144283430401 / 0.012491622786737646 | 2.7241251268074896e-08 / 1.4220454346358598e-06 / 8.270539706935099e-07 / 7.806294817192854e-06 | 0.00739 | 4 |
| 193 | UTRN_3 | 0.0000000000 | 2.360823500030083e-06 / 4.819891610542341e-05 / 0.01459161774480625 / 0.01624353394689184 | 9.96939171389334e-09 / 5.260467316300094e-07 / 3.5243167304031697e-06 / 9.884600038679634e-07 | 0.007721 | 4 |
| 194 | CALU_1 | 0.0000004164 | 8.712601577854501e-09 / 0.029987683740818265 / 4.778480179883678e-05 / 0.0014562282237067896 | 5.266009225225312e-10 / 4.0454271359773727e-07 / 7.672203291248733e-08 / 5.85093501886766e-06 | 0.007873 | 4 |
| 195 | PLAUR_1 | 0.0000000244 | 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 / 0.029987683740818265 | 8.615162127229272e-11 / 9.681579901416002e-07 / 1.4437165409807745e-06 / 9.35433381095111e-06 | 0.007873 | 4 |
| 196 | HIST1H3F_2 | 0.0000000051 | 0.0015927321289850582 / 0.023851866632585955 / 0.00016090253762067176 / 0.006218991828298577 | 2.1956145641009148e-08 / 0.00010324111552331347 / 6.744350520658004e-06 / 6.501852523462225e-05 | 0.007956 | 4 |
| 197 | SHF_2 | 0.0000000138 | 0.001693689356850199 / 0.0014031215699221884 / 0.012735358967208718 / 0.017175407042679062 | 1.935898724207595e-07 / 7.846392075982059e-07 / 9.678320481712436e-06 / 8.427515550712705e-07 | 0.008252 | 4 |
| 198 | CERK_1 | 0.0000008873 | 0.013244448613132145 / 0.0022351613397075614 / 0.015474072817082456 / 0.0029744892448975834 | 0.00020051688200258856 / 0.00018492952950495273 / 0.0012280052280709938 / 0.0005416554989378981 | 0.008482 | 4 |
| 199 | TADA1_1 | 0.0000002147 | 0.016780696985377475 / 0.0005695162353950492 / 0.009231171890260521 / 0.00772762240557102 | 1.4508371309511671e-08 / 6.435719575006254e-08 / 4.82397274391162e-08 / 2.779770649698667e-07 | 0.008577 | 4 |
| 200 | UBA7_1 | 0.0003624359 | 0.0005728902408745853 / 0.003242823752914826 / 0.0027568341257606386 / 0.03172797440821663 | 4.377541835767184e-08 / 1.4020761197150485e-06 / 2.9401803878641854e-05 / 6.058178438606368e-07 | 0.009575 | 4 |
| 201 | SETDB1_1 | 0.0000003780 | 0.0026490796375761676 / 0.0030838618137353662 / 0.0004052971561229435 / 0.03955358967054088 | 5.084831070504725e-08 / 1.5437307336972335e-08 / 2.4314077044074555e-08 / 3.708419532637195e-06 | 0.011423 | 4 |
| 202 | FEV_1 | 0.0000018489 | 0.033538144332397844 / 0.00028614552404424633 / 0.01249350392911133 / 5.910503776729101e-05 | 3.513392334373485e-06 / 3.0193991188193814e-06 / 4.261681658726496e-06 / 3.904348041550831e-06 | 0.011594 | 4 |
| 203 | PLIN3_1 | 0.0000052675 | 0.00029139375190295606 / 0.009220967328515883 / 0.03147989324458417 / 0.008770410107355643 | 4.751419536263273e-07 / 1.5878609213360564e-06 / 2.5660205514983566e-05 / 1.1850407245136544e-05 | 0.012441 | 4 |
| 204 | CAPZB_1 | 0.0000074431 | 0.020797363705116343 / 0.0062029903117365925 / 0.01708229147040032 / 0.012228646417111324 | 3.430820753789497e-07 / 7.116750242001532e-06 / 1.9457058230691574e-05 / 1.4739355201517365e-06 | 0.014078 | 4 |
| 205 | PRR14L_1 | 0.0000287853 | 0.025082579510674555 / 0.0002021790532799894 / 0.012782548244800053 / 0.01903033340546255 | 3.0568724876555808e-06 / 1.7592986743744327e-05 / 0.0003036464804643225 / 9.900533456095719e-05 | 0.014274 | 4 |
| 206 | SYT4_1 | 0.0000045133 | 0.015545833082593517 / 0.02041517410701112 / 0.005606155017185667 / 0.023315264256491483 | 0.0007991296587415927 / 1.5782237178697584e-07 / 3.4514435206822334e-06 / 3.6363448556754176e-05 | 0.016221 | 4 |
| 207 | OSTM1_1 | 0.0000004769 | 0.00029139375190295606 / 0.014437131210731376 / 0.008770410107355643 / 0.042521980850760616 | 1.8325191636828767e-09 / 1.7933002396456563e-06 / 1.209386955631816e-05 / 2.8665654575872185e-06 | 0.016505 | 4 |
| 208 | ALKBH2_5 | 0.0000000000 | 0.0006658217635395392 / 6.408084768025853e-06 / 0.04987195778126702 / 0.025098765971631444 | 1.084736492711166e-08 / 9.593642946100947e-08 / 1.132197770977069e-05 / 2.191320769137121e-05 | 0.018911 | 4 |
| 209 | MSN_1 | 0.0000002383 | 0.01695446499444467 / 0.027498564129629463 / 0.014675290351873422 / 0.018771777160462803 | 4.599537647191073e-06 / 1.9086619291135215e-05 / 4.8131935092059315e-06 / 1.3273993329378002e-05 | 0.019475 | 4 |
| 210 | ESYT2_2 | 0.0000000013 | 0.0030336578784421852 / 0.01671859601940339 / 0.015226777755356039 / 0.04496562784687137 | 3.165663675076115e-09 / 2.3423418225839996e-05 / 5.032307286753409e-07 / 1.2411450689986321e-05 | 0.019986 | 4 |
| 211 | RSBN1_1 | 0.0000185080 | 0.03683753470884825 / 0.011413935706631708 / 0.017145541610166553 / 0.014660785392642973 | 1.433152382574118e-07 / 5.910344738541638e-08 / 2.5220601123022208e-05 / 4.2656913152557095e-06 | 0.020014 | 4 |
| 212 | ATL3_1 | 0.0000008573 | 0.011413935706631708 / 0.014660785392642973 / 0.017443397981769932 / 0.03683753470884825 | 2.938478701650645e-07 / 1.2357184821505046e-06 / 1.34699746919262e-06 / 4.381675501436861e-06 | 0.020089 | 4 |
| 213 | GLCCI1_2 | 0.0000000339 | 0.000506059688566897 / 0.006967423038249733 / 0.04616500613759174 / 0.02830343719752466 | 2.756128143638523e-10 / 8.727903434920509e-10 / 5.197443718190881e-07 / 0.00016721014291291134 | 0.020485 | 4 |
| 214 | STX4_1 | 0.0000103251 | 0.017443397981769932 / 0.017145541610166553 / 0.03683753470884825 / 0.011413935706631708 | 1.149596541548471e-07 / 9.1652846360952e-06 / 2.8282830819547243e-06 / 3.479429274497365e-07 | 0.02071 | 4 |
| 215 | ZFP36_1 | 0.0001056505 | 0.017443397981769932 / 0.017145541610166553 / 0.011413935706631708 / 0.03683753470884825 | 1.737842213973009e-07 / 8.045110852931203e-06 / 6.077495271342403e-05 / 1.3331815375742793e-06 | 0.02071 | 4 |
| 216 | ITPR3_1 | 0.0000001347 | 0.04001855602158032 / 0.02473369613058651 / 0.002494297125613762 / 0.017644496874256163 | 3.1111051486214713e-07 / 3.1246898169649434e-07 / 5.066474066266959e-07 / 6.524401461141414e-06 | 0.021223 | 4 |
| 217 | APEX1_1 | 0.0000125684 | 0.029245906890336886 / 0.039756863847419444 / 0.012044249045532097 / 0.005547335178190005 | 7.501855120464028e-09 / 2.210591549312696e-06 / 0.0010048532388054296 / 7.598158853857719e-07 | 0.021649 | 4 |
| 218 | NAGK_1 | 0.0000090434 | 0.0359209982666861 / 0.02283925689865032 / 0.03203446148966057 / 0.007869203029856895 | 4.857892768176024e-12 / 1.5321698605219521e-06 / 3.1094588442870684e-07 / 1.03713103228835e-07 | 0.024666 | 4 |
| 219 | CTSO_2 | 0.0000000001 | 0.011266491236640721 / 0.04019864979524411 / 0.009925247376618809 / 0.049822690026412035 | 3.138972714567624e-08 / 1.560503101825122e-08 / 9.567048792824493e-06 / 1.998510033084769e-06 | 0.027803 | 4 |
| 220 | GAL3ST3_5 | 0.0000000000 | 1.4966990682807468e-07 / 2.827249605742276e-06 / 3.1413408717447276e-05 | 3.0226583395773654e-07 / 4.251989568762905e-06 / 9.932757607291931e-07 | 1.15E-05 | 3 |
| 221 | UBA52_3 | 0.0000000000 | 1.3603516623392527e-05 / 6.029043389123571e-05 / 5.045497445639472e-05 | 5.851551410932261e-07 / 1.710172873999253e-08 / 1.2158482126235317e-05 | 4.14E-05 | 3 |
| 222 | MSRB3_4 | 0.0000000000 | 6.46451222732421e-05 / 3.720566971124837e-05 / 8.695780204681589e-05 | 7.267015459944046e-07 / 4.887970470660509e-05 / 6.751019417131056e-05 | 6.29E-05 | 3 |
| 223 | MTPAP_3 | 0.0000000001 | 2.4720937454568888e-05 / 1.2751616501556023e-05 / 0.00018587383065277118 | 4.2193212858195527e-07 / 3.403424981067467e-07 / 1.255056828139161e-06 | 7.44E-05 | 3 |
| 224 | UBE2O_4 | 0.0000000000 | 0.00020771366206680562 / 1.528305625592724e-05 / 1.5417123239589966e-05 | 8.204970746839372e-07 / 1.2473665471568327e-05 / 2.207999415422632e-05 | 7.95E-05 | 3 |
| 225 | RANBP17_1 | 0.0000004613 | 0.00013057839781136293 / 2.098169823270148e-06 / 0.00012418009082273935 | 1.5462113719102461e-06 / 1.0841250457737996e-05 / 0.0007974404623478325 | 8.56E-05 | 3 |
| 226 | ZNF516_4 | 0.0000000000 | 3.872664033406607e-06 / 0.00012352623655085027 / 0.00014080284226678161 | 8.633851745836879e-06 / 3.646126773929292e-05 / 4.693534198442505e-05 | 8.94E-05 | 3 |
| 227 | NKAIN1_3 | 0.0000000000 | 6.048904209077932e-07 / 0.0002827019572692268 / 4.565055181871741e-06 | 1.8963600971928307e-07 / 2.4597415093902517e-05 / 8.312648483856273e-05 | 9.6E-05 | 3 |
| 228 | DHX9_3 | 0.0000000000 | 0.00031618213746396326 / 1.5079640407764188e-07 / 3.878104391115258e-05 | 7.324325851139409e-08 / 8.345673558891845e-07 / 5.455940168964712e-06 | 0.000118 | 3 |
| 229 | TET1_4 | 0.0000000000 | 7.04443145456897e-05 / 0.00013097208813100302 / 0.00017715535475236788 | 7.420704863880182e-07 / 1.871920932527521e-06 / 1.2498158253814596e-06 | 0.000126 | 3 |
| 230 | UHMK1_1 | 0.0000020860 | 0.00030051214168214937 / 6.606509042863372e-05 / 9.390951294242489e-05 | 5.795453634595254e-08 / 9.135482956883646e-09 / 5.202287615781549e-07 | 0.000153 | 3 |
| 231 | KCNH8_2 | 0.0000000000 | 6.395893878746714e-08 / 0.0004951577945428809 / 6.246855784844429e-05 | 1.8797523362973878e-08 / 4.636654129462014e-07 / 1.099671115182553e-06 | 0.000186 | 3 |
| 232 | PMEL_1 | 0.0000005663 | 2.098169823270148e-06 / 1.384655004104117e-06 / 0.0006273187563236247 | 6.845101785005541e-09 / 2.3534233465189457e-06 / 7.679394256913984e-07 | 0.00021 | 3 |
| 233 | TMEM177_2 | 0.0000000000 | 0.000218258066644831 / 2.729001089528698e-05 / 0.0005268025057445726 | 5.209193027162048e-08 / 7.210516358215353e-07 / 8.65292135655517e-06 | 0.000257 | 3 |
| 234 | P4HB_3 | 0.0000000000 | 7.235087963937188e-05 / 0.00020977095849751892 / 0.0006140291296563689 | 1.5481316963269385e-06 / 1.2667727790601262e-05 / 2.2318101021362054e-05 | 0.000299 | 3 |
| 235 | GLB1_2 | 0.0000000001 | 0.0008060555543976513 / 0.00015263556465626687 / 0.0002492824297492718 | 5.95245025264109e-07 / 3.0646460084359855e-06 / 2.0252846047441925e-05 | 0.000403 | 3 |
| 236 | NIPSNAP1_5 | 0.0000000000 | 7.0049869888978436e-06 / 0.0005153457051148798 / 0.0006955168425803274 | 1.5111991034910146e-07 / 1.7955354168874533e-06 / 6.9569188414230535e-06 | 0.000406 | 3 |
| 237 | STOX2_4 | 0.0000000003 | 4.1961269753906035e-05 / 0.0010880952015806498 / 0.00010503474822771901 | 8.316576707748038e-07 / 1.514815251496678e-05 / 3.9477756451806046e-06 | 0.000412 | 3 |
| 238 | HIC2_5 | 0.0000000000 | 4.726033274744903e-06 / 0.00013382198113446112 / 0.0013349789650252575 | 9.611997971680818e-09 / 1.1620332716585593e-05 / 3.9355477345741505e-05 | 0.000491 | 3 |
| 239 | DDX25_1 | 0.0000003731 | 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 | 1.6097112876531916e-08 / 3.2052124199850265e-08 / 1.4170604850554317e-07 | 0.000501 | 3 |
| 240 | DNMT3A_1 | 0.0000003165 | 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 | 3.5247387941347504e-08 / 6.731804150774537e-06 / 1.2896794234236179e-05 | 0.000501 | 3 |
| 241 | EXT2_1 | 0.0000003436 | 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 | 2.0783635717550663e-12 / 9.054121086432515e-07 / 2.0219531513922313e-05 | 0.000501 | 3 |
| 242 | FAM129B_1 | 0.0000000190 | 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 | 6.60672131957345e-08 / 5.537377478544649e-08 / 4.1732948235118237e-07 | 0.000501 | 3 |
| 243 | GINM1_1 | 0.0000002753 | 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 | 5.046050215569822e-09 / 5.428070521726932e-08 / 2.1701147223144043e-06 | 0.000501 | 3 |
| 244 | HNRNPA1L2_1 | 0.0000000756 | 8.712601577854501e-09 / 4.778480179883678e-05 / 0.0014562282237067896 | 1.2976171138488909e-09 / 4.5877377333254656e-07 / 1.6836213911883948e-06 | 0.000501 | 3 |
| 245 | MAN1B1_1 | 0.0000001522 | 8.712601577854501e-09 / 0.0014562282237067896 / 4.778480179883678e-05 | 3.0241063676746706e-11 / 1.5906368364620238e-09 / 1.318311055073274e-07 | 0.000501 | 3 |
| 246 | TACC1_1 | 0.0000024323 | 0.0014562282237067896 / 4.778480179883678e-05 / 8.712601577854501e-09 | 6.120199026321514e-07 / 4.1123437302256347e-07 / 1.0614723925305345e-08 | 0.000501 | 3 |
| 247 | RIPK1_5 | 0.0000000000 | 6.840228317523313e-05 / 0.0009512875629473391 / 0.0005924452898671693 | 1.5712671052120772e-06 / 4.09648566039462e-06 / 3.7135622189006208e-06 | 0.000537 | 3 |
| 248 | ZBTB4_3 | 0.0000000000 | 0.0005037641948066041 / 4.1029029786791e-05 / 0.0011809756046229313 | 1.117525634308104e-05 / 2.721755300189734e-07 / 5.303486617820998e-05 | 0.000575 | 3 |
| 249 | TLN1_5 | 0.0000000000 | 1.9703021048281005e-05 / 0.0005523542769980133 / 0.001186882005547644 | 2.022661269835003e-07 / 7.938143861075808e-05 / 8.872728066213042e-06 | 0.000586 | 3 |
| 250 | PCBP3_1 | 0.0000002605 | 8.712601577854501e-09 / 0.0006110060061203364 / 0.0014562282237067896 | 7.776240359663578e-08 / 1.638864761384365e-06 / 1.2093871604348117e-06 | 0.000689 | 3 |
| 251 | KIDINS220_2 | 0.0000000000 | 0.0018859337356087994 / 0.0001930893136831812 / 4.710776942634132e-06 | 5.072414419210524e-06 / 1.9800037664169994e-06 / 3.568737378774764e-05 | 0.000695 | 3 |
| 252 | MYH9_4 | 0.0000000000 | 0.0011716362540399527 / 2.5874889458489842e-05 / 0.00098592835353018 | 1.1606044222659936e-05 / 5.315659303841256e-07 / 0.0002008409108671274 | 0.000728 | 3 |
| 253 | C2orf43_4 | 0.0000000000 | 5.393578869543922e-07 / 0.0023453445326236527 / 1.354525793237082e-06 | 6.595211500412567e-08 / 3.985671655723259e-07 / 6.693718279433329e-07 | 0.000782 | 3 |
| 254 | CFLAR_5 | 0.0000000000 | 2.366050283623384e-07 / 1.8250670479244966e-06 / 0.0026884317876910953 | 4.986931710131805e-06 / 3.457834181885606e-06 / 1.5979548021423277e-06 | 0.000897 | 3 |
| 255 | RAB27A_5 | 0.0000000000 | 4.235470787154264e-07 / 0.00048364115746124477 / 0.002294886679155574 | 1.5348969527407146e-08 / 1.8046897740630015e-06 / 4.1788406415060826e-05 | 0.000926 | 3 |
| 256 | PLSCR4_2 | 0.0000000029 | 4.859413804591664e-05 / 0.0027548209719256856 / 0.00020561631972662475 | 3.3117537208770918e-09 / 1.148805004150062e-06 / 4.664969309642537e-06 | 0.001003 | 3 |
| 257 | RPUSD4_1 | 0.0000007330 | 0.001066805887839933 / 0.0005152101842532016 / 0.0015298583359982347 | 2.3615410532322286e-05 / 4.319838908046999e-06 / 0.0002330489716331065 | 0.001037 | 3 |
| 258 | MPST_3 | 0.0000000016 | 0.00013736583753548478 / 0.0030443962453463847 / 8.033145753215765e-06 | 3.289559261620218e-06 / 3.976886270875369e-06 / 1.171567023312239e-06 | 0.001063 | 3 |
| 259 | MSN_1 | 0.0000002015 | 0.0019027179320774803 / 0.0012733956455115425 / 0.0003168019030192227 | 9.67855150073715e-08 / 3.184222031943731e-08 / 4.6792815745596373e-07 | 0.001164 | 3 |
| 260 | TGFB1I1_1 | 0.0000000689 | 0.0012733956455115425 / 0.0003168019030192227 / 0.0019027179320774803 | 9.602262969345956e-07 / 1.898080280214667e-06 / 4.85147907436071e-06 | 0.001164 | 3 |
| 261 | PRMT1_2 | 0.0000000003 | 2.8649381309321584e-06 / 0.00013104001909797732 / 0.00341452788547584 | 3.7442073966474697e-11 / 2.696236533103196e-06 / 4.175789992611833e-06 | 0.001183 | 3 |
| 262 | AGPAT3_3 | 0.0000000000 | 0.0009240199113069562 / 0.001726211324732259 / 0.0009222051384671301 | 1.4076606607890667e-05 / 6.064432655122854e-06 / 0.00046211741435037205 | 0.001191 | 3 |
| 263 | NUPR1_2 | 0.0000000008 | 1.2731341624968911e-05 / 5.8997927541035875e-06 / 0.003561757705418032 | 6.730910090199648e-07 / 2.3445593630205304e-06 / 1.3063148311515809e-05 | 0.001193 | 3 |
| 264 | RNPC3_2 | 0.0000000375 | 0.0025602598027028244 / 5.469917899643988e-05 / 0.0010104633264639477 | 1.393467985718326e-06 / 7.829150593953611e-07 / 0.00010845460486238517 | 0.001208 | 3 |
| 265 | S100A6_2 | 0.0000000006 | 0.0033273695719493366 / 0.0003451393798156882 / 2.1541055929197527e-08 | 1.7609429749647884e-07 / 5.870724758098998e-07 / 1.1681749490132842e-07 | 0.001224 | 3 |
| 266 | GADD45B_2 | 0.0000000000 | 0.00010634683697229356 / 0.003790365456096317 / 1.8397621446509385e-05 | 1.705317052907576e-07 / 8.878912678862584e-06 / 2.2556761049368962e-07 | 0.001305 | 3 |
| 267 | IRF2_2_5 | 0.0000015405 | 0.0008574554508689445 / 0.003180287587180633 / 6.994095656900796e-05 | 9.872538086030946e-08 / 1.5355274708245824e-06 / 2.245172851097339e-06 | 0.001369 | 3 |
| 268 | MVP_2_3 | 0.0000000046 | 0.00024759203487775524 / 1.1168409277359634e-06 / 0.004671632294386495 | 1.4353154937155882e-08 / 5.633740184888267e-07 / 7.385772453731096e-05 | 0.00164 | 3 |
| 269 | GTF2H5_2 | 0.0000000066 | 0.0002128703129063878 / 0.002908963894359682 / 0.0018958315428404735 | 5.915610064271708e-09 / 5.737302226316655e-07 / 1.2839131009976642e-05 | 0.001673 | 3 |
| 270 | AGTPBP1_2 | 0.0000000112 | 0.00010643560926875712 / 0.0014494282385407017 / 0.003851986494620127 | 3.4005559000932834e-05 / 5.086114917232466e-05 / 2.3120980016650736e-05 | 0.001803 | 3 |
| 271 | TAGLN2_5 | 0.0000000000 | 0.0023516155321212286 / 0.0005452799037971314 / 0.002719578191920108 | 5.193860370029491e-08 / 1.8066076033567137e-05 / 2.887575861701981e-05 | 0.001872 | 3 |
| 272 | CCNT1_4 | 0.0000000000 | 0.00022838881607180578 / 2.554651598059182e-05 / 0.006324061390967165 | 5.780726368884951e-06 / 4.298018160630921e-06 / 8.210854046814278e-06 | 0.002193 | 3 |
| 273 | KCNN4_1 | 0.0000000002 | 0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227 | 1.128508207742848e-07 / 3.8845776675460915e-08 / 1.2490905944573221e-07 | 0.002278 | 3 |
| 274 | PEA15_1 | 0.0000000021 | 0.004613449756294485 / 0.0003168019030192227 / 0.0019027179320774803 | 3.828734914704096e-08 / 3.8329007469588033e-07 / 4.539908056270449e-05 | 0.002278 | 3 |
| 275 | SAMD9_1 | 0.0000020075 | 0.004613449756294485 / 0.0019027179320774803 / 0.0003168019030192227 | 1.631780084189698e-08 / 1.293907975082848e-05 / 2.4553942312433883e-05 | 0.002278 | 3 |
| 276 | TRADD_3 | 0.0000000103 | 0.0009229889305125405 / 0.005966882987573243 / 0.00022527887387849618 | 1.9518812703705133e-06 / 0.0006939505597308152 / 1.9336719955298165e-06 | 0.002372 | 3 |
| 277 | TAF5_3 | 0.0000000136 | 0.0003947059228531657 / 0.00045641021220350523 / 0.006335832620557736 | 1.7233340819541832e-07 / 2.5952887221237527e-06 / 8.18333648588888e-05 | 0.002396 | 3 |
| 278 | EFHD2_4 | 0.0000000000 | 0.00723849757956334 / 1.3696651981584819e-05 / 6.311409747603608e-05 | 2.4861210722153842e-05 / 2.247788787753732e-05 / 1.516759330888414e-06 | 0.002438 | 3 |
| 279 | YIPF2_1 | 0.0000006993 | 0.0008973831238703076 / 0.0005658979552839525 / 0.0060047412034100744 | 9.922731214680193e-08 / 7.852806908257148e-06 / 0.0001985413552316056 | 0.002489 | 3 |
| 280 | ZBED4_2 | 0.0000001314 | 0.0007128826028020409 / 0.0020168985989813806 / 0.00482573534583834 | 9.098868701321864e-08 / 1.2243260078905274e-05 / 0.0008067113425139145 | 0.002519 | 3 |
| 281 | RAB3C_1 | 0.0000014208 | 0.0012733956455115425 / 0.004613449756294485 / 0.0019027179320774803 | 5.90994322935669e-07 / 1.1108797731264583e-05 / 4.4376112397274685e-05 | 0.002597 | 3 |
| 282 | FOSL1_4 | 0.0000000000 | 0.007490059087712426 / 0.00021444125068471832 / 0.00012920787797071663 | 5.556372147557157e-06 / 7.999218077760667e-07 / 2.9367679374215882e-05 | 0.002611 | 3 |
| 283 | INA_2 | 0.0000002325 | 0.000506059688566897 / 0.006967423038249733 / 0.000365164824725025 | 2.655622703010865e-07 / 6.037515871423344e-07 / 0.001167614468808287 | 0.002613 | 3 |
| 284 | FLVCR1_2 | 0.0000000042 | 5.3340489000579145e-05 / 0.0015899100236963135 / 0.006521228618588356 | 1.302715543173824e-07 / 3.714456265544689e-05 / 1.704949565638429e-05 | 0.002721 | 3 |
| 285 | ATF7IP2_5 | 0.0000000000 | 0.0032839512279112418 / 0.002993599664223763 / 0.002476029139206104 | 8.537589066325822e-06 / 2.5436790588774414e-05 / 5.142377607346069e-07 | 0.002918 | 3 |
| 286 | S100A10_1 | 0.0000008705 | 0.0030838618137353662 / 0.0016555906467057811 / 0.004531342266561176 | 1.1613890918983097e-06 / 1.6946838169885616e-05 / 9.665990417390237e-05 | 0.00309 | 3 |
| 287 | TRIP6_1 | 0.0000002147 | 6.392429369799613e-05 / 0.008158453075892491 / 0.0012146763275784356 | 3.2750776669883485e-08 / 4.272773668654882e-07 / 5.404314030094148e-07 | 0.003146 | 3 |
| 288 | EIF3J_2 | 0.0000000002 | 0.005021029517387429 / 0.004594623942981826 / 0.0005725315156474846 | 1.0666101484276558e-06 / 8.707499404147844e-06 / 7.206761532626187e-07 | 0.003396 | 3 |
| 289 | CASP4_1 | 0.0000000780 | 0.008158453075892491 / 0.0012146763275784356 / 0.0011036487237694873 | 2.347967797408527e-08 / 1.0559189019803553e-06 / 3.278522050115709e-06 | 0.003492 | 3 |
| 290 | NSL1_2 | 0.0000000033 | 5.3340489000579145e-05 / 0.011092727550841517 / 5.792866128396694e-05 | 2.2018205271807595e-07 / 0.00024742638651566884 / 3.7695931576460654e-06 | 0.003735 | 3 |
| 291 | VASP_1 | 0.0000006404 | 0.009220967328515883 / 0.00029139375190295606 / 0.002271551295087959 | 1.683199820716066e-07 / 2.799847052848426e-07 / 5.915001438135837e-07 | 0.003928 | 3 |
| 292 | COG2_3 | 0.0000000010 | 0.012184597869329615 / 0.00017818061059800717 / 3.3817330366409276e-05 | 9.88977547194958e-07 / 9.135799923405938e-08 / 3.6569660447432056e-05 | 0.004132 | 3 |
| 293 | STMN4_3 | 0.0000000000 | 2.061341498862413e-06 / 0.013557269953071502 / 0.00016739297171412964 | 1.1827971870760236e-07 / 1.7028450668349932e-05 / 2.2310679101285705e-05 | 0.004576 | 3 |
| 294 | ARID2_1 | 0.0000005167 | 0.009220967328515883 / 0.00029139375190295606 / 0.004557941079021841 | 2.2639222896451386e-07 / 1.109801352982852e-06 / 2.1017914639263102e-07 | 0.00469 | 3 |
| 295 | TMEM145_2 | 0.0000000541 | 0.011857375508327873 / 0.0019384937218085618 / 0.0003086352962437011 | 3.703004816743222e-08 / 9.472094543228691e-06 / 3.7868771404399016e-07 | 0.004702 | 3 |
| 296 | RPS28_2 | 0.0000000062 | 0.0013196713645063731 / 0.00015680243457987764 / 0.013122781516773055 | 2.4859140381808595e-07 / 8.661018242204261e-07 / 1.0278447900767023e-05 | 0.004866 | 3 |
| 297 | BHLHB9_5 | 0.0000000000 | 0.000833093052382085 / 0.0017373454847881562 / 0.012094762315019585 | 0.0003876834856951191 / 0.00025814098757798783 / 0.0012619942783536312 | 0.004888 | 3 |
| 298 | CCT3_2 | 0.0000003320 | 0.0053229089046933666 / 0.0035672102749117456 / 0.006424879308109518 | 1.385234000351963e-09 / 1.1973928792856672e-07 / 8.271151178245213e-07 | 0.005105 | 3 |
| 299 | ZBTB39_1 | 0.0000012961 | 0.0002459835698877307 / 0.012131971219889692 / 0.003904810749383955 | 1.947682987909157e-09 / 4.769808257064375e-06 / 1.009907236026598e-05 | 0.005428 | 3 |
| 300 | TGFBI_1 | 0.0000001859 | 0.014968932619439228 / 0.00029139375190295606 / 0.002271551295087959 | 8.323645474851572e-06 / 2.8646241152477385e-06 / 2.2007597669701546e-05 | 0.005844 | 3 |
| 301 | DRAM1_2 | 0.0000000007 | 3.95395916749111e-05 / 0.005028962391482225 / 0.012655371032190181 | 7.334418459565927e-07 / 2.9757670605999017e-06 / 7.803574545937928e-05 | 0.005908 | 3 |
| 302 | TTC9B_4 | 0.0000000010 | 3.2451983838054593e-06 / 0.0027782153739561613 / 0.015336438182107533 | 5.579389394627073e-06 / 2.6478455347372e-05 / 6.774767693632554e-05 | 0.006039 | 3 |
| 303 | CRABP1_2 | 0.0000000000 | 0.00018053504491942103 / 0.0006013127917976173 / 0.017420025549877295 | 3.6420294337565723e-08 / 4.7891636027032046e-05 / 2.4547340474687967e-05 | 0.006067 | 3 |
| 304 | PRNP_1 | 0.0000012041 | 0.008158453075892491 / 0.01165101001080378 / 0.0011036487237694873 | 1.1937594193840056e-07 / 3.852111240660634e-06 / 7.982699562459387e-07 | 0.006971 | 3 |
| 305 | RNF216_2 | 0.0000000710 | 0.01978912870326623 / 0.0009038593586046481 / 0.001339659580920153 | 1.2928230810660568e-06 / 1.509161544583804e-07 / 3.464852330723318e-06 | 0.007344 | 3 |
| 306 | KCNH2_1 | 0.0000005910 | 0.0011929519758551942 / 0.013144247549246738 / 0.007698641086675404 | 4.050881868723152e-06 / 5.993445368097023e-06 / 9.184683537215863e-05 | 0.007345 | 3 |
| 307 | HDAC2_1 | 0.0000111884 | 0.0013546126949011356 / 0.015529327313804105 / 0.0060782790336966815 | 8.678070199327975e-10 / 9.165188556262711e-07 / 1.9640719268488575e-07 | 0.007654 | 3 |
| 308 | LDLRAD3_2 | 0.0000000086 | 0.000790463498248653 / 0.022196441234578132 / 2.1369034750623554e-06 | 2.3758722136689975e-06 / 9.69193707515232e-05 / 3.165236790324336e-05 | 0.007663 | 3 |
| 309 | DLG2_1 | 0.0000004953 | 9.390951294242489e-05 / 4.611763366846969e-05 / 0.023379270483941148 | 1.6435897498809227e-05 / 8.947838561493191e-07 / 0.0005491970493346228 | 0.00784 | 3 |
| 310 | ABHD2_2 | 0.0000007167 | 0.007702284030015268 / 0.015157007205383797 / 0.002098496534836373 | 6.150334665817541e-07 / 2.79918960850902e-06 / 1.3380586388949062e-06 | 0.008319 | 3 |
| 311 | FICD_1 | 0.0000000879 | 0.00042879723237597764 / 0.003993715376548959 / 0.02118368053863915 | 2.9785947869700167e-06 / 6.873856442248643e-07 / 6.404598440436032e-07 | 0.008535 | 3 |
| 312 | EML5_1 | 0.0000186293 | 0.0003816779304374477 / 0.007313973432554173 / 0.019582037452342965 | 1.768922156010669e-08 / 3.733774907814613e-07 / 8.463320131580384e-05 | 0.009093 | 3 |
| 313 | ZNF280B_1 | 0.0000176080 | 0.0002021790532799894 / 0.012782548244800053 / 0.015382714940475899 | 4.16735367252946e-06 / 1.8932170047411166e-06 / 0.0006150439183333181 | 0.009456 | 3 |
| 314 | MAST1_1 | 0.0000012460 | 0.0030838618137353662 / 0.0016555906467057811 / 0.02419315699804896 | 1.008321219643804e-08 / 6.59179220363995e-08 / 2.8729044379438386e-06 | 0.009644 | 3 |
| 315 | NBR2_4 | 0.0000000013 | 0.0030139413806392025 / 0.02262700624929458 / 0.004062778899218961 | 2.6809213542125635e-07 / 3.3592733116787e-06 / 5.084507985309251e-05 | 0.009901 | 3 |
| 316 | ZSCAN16_1 | 0.0000021993 | 0.009406629582018086 / 0.007054606953047138 / 0.013414705614259708 | 3.1919700086632823e-08 / 4.241176857088593e-06 / 1.10182899392691e-05 | 0.009959 | 3 |
| 317 | CD109_1 | 0.0000004857 | 0.0030838618137353662 / 0.026132194840960694 / 0.0016555906467057811 | 4.1459663612593765e-07 / 1.133270373704853e-05 / 6.95591696890365e-07 | 0.010291 | 3 |
| 318 | ASCL1_1 | 0.0000012961 | 8.712601577854501e-09 / 0.0014562282237067896 / 0.029987683740818265 | 6.622928776298776e-08 / 4.986303622240574e-07 / 5.121638955023879e-05 | 0.010481 | 3 |
| 319 | PRCC_2 | 0.0000000009 | 0.02916029058932568 / 1.4053286193768942e-05 / 0.0033436620457161664 | 4.234540029087047e-09 / 7.396677617376084e-08 / 5.762915371340719e-06 | 0.010839 | 3 |
| 320 | SYPL1_3 | 0.0000000001 | 0.0010868506221494473 / 0.03062224194622656 / 0.0008798790932645847 | 1.8036241827089262e-07 / 1.170707624311846e-06 / 8.621104111789159e-06 | 0.010863 | 3 |
| 321 | CACNA1B_3 | 0.0000023253 | 0.0006313127973618962 / 0.026533133928238382 / 0.00548175365183452 | 4.657105147722875e-06 / 0.00011767035322254456 / 0.0009513496148143766 | 0.010882 | 3 |
| 322 | FEV_3 | 0.0000000016 | 0.0018157417923330308 / 0.0005005652894286239 / 0.03138718307129687 | 5.9293955966041735e-08 / 1.9491788120934706e-06 / 3.089744526549523e-05 | 0.011234 | 3 |
| 323 | VSTM2A_2 | 0.0000000860 | 0.000506059688566897 / 0.02830343719752466 / 0.005186853257558283 | 4.451709831952587e-07 / 0.0006571117480683702 / 0.0019723456239841616 | 0.011332 | 3 |
| 324 | DOC2A_1 | 0.0000176432 | 0.00025234279143195943 / 0.005397134900618702 / 0.028677370706029427 | 2.097886384356248e-06 / 4.3459478389049724e-07 / 7.808876942721705e-07 | 0.011442 | 3 |
| 325 | MTR_1 | 0.0000001011 | 9.388757698010748e-05 / 0.015063580358728427 / 0.020113164514031456 | 2.0462926382898192e-05 / 2.0838053089232e-06 / 0.0006005512194214275 | 0.011757 | 3 |
| 326 | TMEM184B_1 | 0.0000052583 | 0.017443397981769932 / 0.002318126437551203 / 0.017145541610166553 | 5.074118788922354e-08 / 1.528139375785279e-07 / 1.361457730245486e-06 | 0.012302 | 3 |
| 327 | ARID2_3 | 0.0000002768 | 0.005599828148522198 / 0.014996743361982036 / 0.018170592466726792 | 9.116542240665922e-09 / 1.5456378377669386e-06 / 4.750875211998681e-06 | 0.012922 | 3 |
| 328 | TSEN54_2 | 0.0000000000 | 0.00021036438824558563 / 0.0016249672415913465 / 0.03836197892479358 | 1.419950215795548e-07 / 1.6203351133132878e-07 / 1.5720016310468745e-05 | 0.013399 | 3 |
| 329 | LAMP2_1 | 0.0000061826 | 0.0006291978832262494 / 0.017133475216302412 / 0.02253012830344572 | 2.3046914608799517e-06 / 5.662655646886999e-07 / 4.09648566039462e-06 | 0.013431 | 3 |
| 330 | GPX8_1 | 0.0000006021 | 0.007054606953047138 / 0.009406629582018086 / 0.024046868563271137 | 7.3135246584530174e-09 / 6.656311691714102e-10 / 6.25392798502714e-06 | 0.013503 | 3 |
| 331 | PRIM1_1 | 0.0000003223 | 0.0019943829025712437 / 0.032332967518234994 / 0.006230194892575304 | 7.867184240616801e-06 / 5.037758463198267e-08 / 2.7703126525457583e-06 | 0.013519 | 3 |
| 332 | MMD_3 | 0.0000000000 | 0.00026462416519984375 / 0.04009931021218081 / 0.0018585225095028022 | 3.265086074696618e-08 / 3.8983782729439324e-05 / 5.764266261871919e-06 | 0.014074 | 3 |
| 333 | HSPD1_1 | 0.0000016837 | 0.029245906890336886 / 0.012044249045532097 / 0.0010265738076671066 | 3.4847461970373735e-08 / 5.585527560266155e-06 / 7.023185063013887e-06 | 0.014106 | 3 |
| 334 | TNFRSF12A_5 | 0.0000000000 | 0.032768876151590194 / 0.009211796235391962 / 0.0006064986533695733 | 9.11501895060049e-06 / 1.6191708335697414e-05 / 3.563543914807607e-06 | 0.014196 | 3 |
| 335 | PLP2_4 | 0.0000000002 | 0.043329534197300235 / 4.1971169891966186e-05 / 0.00011139453192955434 | 4.795701871201485e-07 / 3.953822199723069e-06 / 0.002463554449974249 | 0.014494 | 3 |
| 336 | SNX3_1 | 0.0000004514 | 0.012469105184180684 / 0.009827915816152012 / 0.02176087444903759 | 1.575326562154422e-07 / 1.0953632726584286e-07 / 4.669480873853378e-06 | 0.014686 | 3 |
| 337 | SMC3_1 | 0.0000067784 | 0.01903033340546255 / 0.025082579510674555 / 0.0002021790532799894 | 7.004137458574501e-07 / 7.700331048016097e-07 / 1.9353158268148655e-06 | 0.014772 | 3 |
| 338 | ARHGAP1_1 | 0.0000026967 | 0.017145541610166553 / 0.011413935706631708 / 0.017443397981769932 | 1.3146010474489681e-05 / 4.804751045086965e-06 / 2.132159178159428e-06 | 0.015334 | 3 |
| 339 | LPP_1 | 0.0000033409 | 0.01487722458866696 / 0.0017052769733922298 / 0.02985182122259529 | 1.546223090931648e-07 / 4.2508307877523196e-08 / 1.4414883845347043e-06 | 0.015478 | 3 |
| 340 | MGAT1_1 | 0.0000004092 | 0.014660785392642973 / 0.017145541610166553 / 0.017443397981769932 | 1.7966684116150096e-06 / 5.116593940505276e-06 / 1.3410770868177782e-06 | 0.016417 | 3 |
| 341 | TNFRSF1A_3 | 0.0000000002 | 0.0028067534068265437 / 0.00042105945887903654 / 0.048060814464615735 | 1.0121421064420374e-05 / 7.452615942617135e-06 / 9.353097000119014e-05 | 0.017096 | 3 |
| 342 | C12orf10_1 | 0.0000001344 | 0.01695446499444467 / 0.014675290351873422 / 0.02095078822868191 | 9.883275335709048e-07 / 3.3979035604139886e-07 / 1.4183511170080205e-05 | 0.017527 | 3 |
| 343 | KLF15_1 | 0.0000009834 | 0.02839442496647524 / 0.011495528751480646 / 0.017748059549662194 | 2.539351518692909e-07 / 3.996180547635244e-06 / 3.72884546184977e-07 | 0.019213 | 3 |
| 344 | RSL1D1_1 | 0.0000024224 | 0.029245906890336886 / 0.029072859932669184 / 0.001209619547547507 | 1.928466390137773e-09 / 1.7774626241888566e-05 / 2.7621925072470266e-06 | 0.019843 | 3 |
| 345 | CDK2AP2_1 | 0.0000069090 | 0.03413875749258289 / 0.008813705248904322 / 0.017145541610166553 | 7.980991943354118e-06 / 9.182341905056802e-07 / 6.046703803974713e-06 | 0.020033 | 3 |
| 346 | ENOX1_1 | 0.0000096565 | 0.017443397981769932 / 0.03683753470884825 / 0.008813705248904322 | 8.46495419886903e-08 / 2.477238173018046e-06 / 5.706880115624909e-06 | 0.021032 | 3 |
| 347 | KLHL36_1 | 0.0000009988 | 0.017443397981769932 / 0.03683753470884825 / 0.008813705248904322 | 8.55516827501211e-06 / 5.0553384219596765e-06 / 3.3892208678789174e-05 | 0.021032 | 3 |
| 348 | C1R_1 | 0.0000103261 | 0.017443397981769932 / 0.011413935706631708 / 0.03683753470884825 | 5.223576944443697e-10 / 1.278142542397936e-07 / 9.066430827258057e-08 | 0.021898 | 3 |
| 349 | DLL3_1 | 0.0000022545 | 0.017443397981769932 / 0.011413935706631708 / 0.03683753470884825 | 2.879808838966571e-07 / 6.993476243540988e-06 / 7.726331259366366e-07 | 0.021898 | 3 |
| 350 | NPC1_1 | 0.0000013000 | 0.023996288711547777 / 0.014582218475483697 / 0.027344357279935363 | 5.764157631131607e-07 / 2.4200174195178475e-06 / 8.775983171046948e-07 | 0.021974 | 3 |
| 351 | BPTF_1 | 0.0000012059 | 0.0010265738076671066 / 0.029245906890336886 / 0.039756863847419444 | 2.75081594060756e-06 / 1.849240931697844e-06 / 9.833875885810182e-05 | 0.023343 | 3 |
| 352 | CCNB1IP1_1 | 0.0000010768 | 0.029245906890336886 / 0.0010265738076671066 / 0.039756863847419444 | 5.5727604077632575e-08 / 1.0079899592111368e-06 / 6.245632688934216e-06 | 0.023343 | 3 |
| 353 | NPC2_1 | 0.0000110270 | 0.03683753470884825 / 0.017443397981769932 / 0.017145541610166553 | 2.895916979465306e-07 / 4.350257929933473e-06 / 5.881485803416461e-06 | 0.023809 | 3 |
| 354 | ABAT_3 | 0.0000000001 | 0.034052040127872246 / 0.006551644901500213 / 0.03343958590730531 | 4.991017761660758e-05 / 1.6284836400790797e-06 / 5.991633249924668e-06 | 0.024681 | 3 |
| 355 | CEP170_3 | 0.0000000001 | 2.3886446874268867e-06 / 3.5555136352418323e-06 | 8.64144400156011e-07 / 9.9452244969615e-06 | 2.97E-06 | 2 |
| 356 | NUCB1_3 | 0.0000000000 | 9.120027832512087e-06 / 4.9060208885387406e-06 | 4.76082633817649e-08 / 1.542543895417389e-06 | 7.01E-06 | 2 |
| 357 | LAMP1_5 | 0.0000000000 | 7.561570077756679e-06 / 7.75081771574093e-06 | 1.0518690072819026e-09 / 7.017816798332179e-06 | 7.66E-06 | 2 |
| 358 | MAP4_2 | 0.0000000001 | 2.1541055929197527e-08 / 1.9308695609987287e-05 | 3.93734689573353e-09 / 7.038983428807821e-07 | 9.67E-06 | 2 |
| 359 | MSH6_1 | 0.0000000525 | 2.098169823270148e-06 / 1.7711409436331332e-05 | 2.9237170575647894e-07 / 3.223701677601978e-06 | 9.9E-06 | 2 |
| 360 | NECAP2_5 | 0.0000000000 | 1.1734627356832365e-05 / 1.4727302282280241e-05 | 6.34621052304883e-05 / 9.263010355358496e-05 | 1.32E-05 | 2 |
| 361 | RFX7_1 | 0.0000006461 | 1.8023978844296698e-06 / 3.772462305351297e-05 | 1.3777889602205754e-05 / 5.134420163197374e-06 | 1.98E-05 | 2 |
| 362 | LOXL1_1 | 0.0000000613 | 8.712601577854501e-09 / 4.778480179883678e-05 | 3.7451852636473064e-09 / 3.520223337931936e-07 | 2.39E-05 | 2 |
| 363 | RAB11FIP5_1 | 0.0000003435 | 8.712601577854501e-09 / 4.778480179883678e-05 | 8.30614778438761e-09 / 1.875106499909923e-05 | 2.39E-05 | 2 |
| 364 | SYNC_1 | 0.0000000544 | 8.712601577854501e-09 / 4.778480179883678e-05 | 1.8300368947275955e-09 / 1.1156949187536687e-06 | 2.39E-05 | 2 |
| 365 | MYT1_2 | 0.0000000000 | 4.852661376064752e-06 / 5.1682368391364916e-05 | 6.5288974923630765e-06 / 2.33136261456977e-05 | 2.83E-05 | 2 |
| 366 | CNTNAP2_4 | 0.0000000000 | 1.9536120969160626e-05 / 4.855499097832519e-05 | 2.69621468363523e-05 / 0.0005954550144190784 | 3.4E-05 | 2 |
| 367 | SMARCA5_4 | 0.0000000000 | 3.104247296762117e-05 / 4.761108954152855e-05 | 1.84536023077791e-05 / 3.4952774168035884e-05 | 3.93E-05 | 2 |
| 368 | B3GNT9_4 | 0.0000000000 | 4.759424034644978e-06 / 0.00012294606259085342 | 1.6260769696128954e-06 / 0.00010634285087971367 | 6.39E-05 | 2 |
| 369 | GAL_2 | 0.0000000005 | 1.1566938688714122e-08 / 0.0001375276427082929 | 1.8119993137342534e-06 / 0.0013149790281325572 | 6.88E-05 | 2 |
| 370 | TRIM56_5 | 0.0000000000 | 0.00014260412953936538 / 2.3479938806380944e-08 | 3.859067457796533e-06 / 3.656262715818669e-07 | 7.13E-05 | 2 |
| 371 | CRIM1_3 | 0.0000000004 | 4.8106808740888186e-05 / 0.00010014977875691996 | 9.846475238177379e-06 / 5.579017068717648e-08 | 7.41E-05 | 2 |
| 372 | PNMA3_5 | 0.0000000000 | 1.701692255505357e-06 / 0.00014830625115725305 | 2.0336906370795427e-06 / 9.840133053947521e-06 | 7.5E-05 | 2 |
| 373 | HIST3H2A_3 | 0.0000000000 | 7.513947614807362e-05 / 0.00011429921060857062 | 1.068586509856438e-06 / 3.0653385085725396e-07 | 9.47E-05 | 2 |
| 374 | ATCAY_5 | 0.0000000000 | 5.4278236645845715e-06 / 0.00020534480614177087 | 7.732934718383503e-06 / 2.75413488861665e-05 | 0.000105 | 2 |
| 375 | SMARCA4_2 | 0.0000000016 | 2.321730111153503e-06 / 0.00022187513044902743 | 2.120449751487153e-08 / 3.5992692804583596e-05 | 0.000112 | 2 |
| 376 | LIN28B_2 | 0.0000000000 | 1.216331498209144e-06 / 0.00029774828278028234 | 1.1201154484621356e-09 / 7.926073637103903e-06 | 0.000149 | 2 |
| 377 | OLFML2A_5 | 0.0000000000 | 8.951974512115386e-05 / 0.00034027362168927155 | 9.130549898240117e-07 / 2.4504382448983827e-06 | 0.000215 | 2 |
| 378 | ACP1_5 | 0.0000000000 | 6.364279791640112e-06 / 0.0004408162010949017 | 1.6688642528792083e-06 / 1.8017876923145952e-05 | 0.000224 | 2 |
| 379 | ACTL6B_3 | 0.0000000040 | 0.0003057625951752015 / 0.00015450477319284894 | 1.060226377821344e-06 / 2.1353909002247907e-05 | 0.00023 | 2 |
| 380 | PHF21B_4 | 0.0000000000 | 7.623480320281502e-07 / 0.0004987725781895633 | 5.2768179043587e-06 / 1.09188294232324e-06 | 0.00025 | 2 |
| 381 | BAZ1A_1 | 0.0000069836 | 0.00064922210107833 / 1.8023978844296698e-06 | 1.6595910049899672e-07 / 4.925632831272468e-06 | 0.000326 | 2 |
| 382 | TMEM30A_1 | 0.0000022161 | 0.0006240411433431414 / 5.2470753247363745e-05 | 3.5429731576541734e-08 / 5.5462823621098335e-08 | 0.000338 | 2 |
| 383 | NOL11_2 | 0.0000000000 | 0.00046464339325169037 / 0.0002564595505663515 | 5.933716019020396e-07 / 7.456072877479674e-09 | 0.000361 | 2 |
| 384 | BEND4_5 | 0.0000000000 | 1.5777685999047575e-06 / 0.0007208108997517884 | 5.3901186417921756e-11 / 2.815995740727121e-07 | 0.000361 | 2 |
| 385 | ELOVL1_3 | 0.0000000020 | 0.0006923847970197059 / 3.196763725059841e-05 | 2.677497381339075e-07 / 0.00021491113805745135 | 0.000362 | 2 |
| 386 | PFKM_4 | 0.0000000000 | 0.0007309049115603717 / 8.501642925216299e-06 | 9.403882200312194e-08 / 7.819007418155511e-07 | 0.00037 | 2 |
| 387 | NMNAT1_2 | 0.0000000129 | 0.0004526675305989492 / 0.0003016808649104736 | 9.397755887797147e-06 / 0.00010313370779319529 | 0.000377 | 2 |
| 388 | TIGD1_2 | 0.0000000029 | 0.00015234942199771114 / 0.000651352109304205 | 8.064616695114456e-07 / 4.491126688099632e-05 | 0.000402 | 2 |
| 389 | ARL1_5 | 0.0000000000 | 1.694043434756899e-05 / 0.0008334490663588983 | 2.2314679547176197e-07 / 4.126172052886268e-06 | 0.000425 | 2 |
| 390 | CPLX1_4 | 0.0000000002 | 0.0008665554418518524 / 5.737321179382452e-06 | 5.87667964571385e-06 / 3.438314234654185e-05 | 0.000436 | 2 |
| 391 | PAX6_5 | 0.0000000000 | 0.00027854752254638905 / 0.0006006286848231235 | 1.3031733956534446e-07 / 2.2950534119176534e-06 | 0.00044 | 2 |
| 392 | ANXA2_5 | 0.0000000000 | 0.00022245643971115814 / 0.0008228851369949542 | 0.0002774948155360362 / 4.3531858337072534e-05 | 0.000523 | 2 |
| 393 | BHLHE41_1 | 0.0000003123 | 3.679473658399758e-05 / 0.0010281262291342236 | 5.186786515718226e-05 / 4.276807002378442e-05 | 0.000532 | 2 |
| 394 | DPYSL5_2 | 0.0000000245 | 0.0005017064663366604 / 0.0006658727095010238 | 1.0246351818305243e-08 / 2.9985183250414335e-08 | 0.000584 | 2 |
| 395 | NCL_5 | 0.0000000000 | 0.0001902762125730563 / 0.0010196091469089486 | 1.1394612086185451e-07 / 5.477181895031346e-05 | 0.000605 | 2 |
| 396 | NEK6_3 | 0.0000000000 | 0.00042892841962168427 / 0.0007955623084328148 | 4.625637105430227e-06 / 1.9802846632838944e-05 | 0.000612 | 2 |
| 397 | ADAM11_1 | 0.0000014021 | 0.00020676489909411184 / 0.0010623957357494855 | 6.162977005662482e-06 / 1.5065356540452738e-05 | 0.000635 | 2 |
| 398 | BMP1_1 | 0.0000001479 | 8.712601577854501e-09 / 0.0014562282237067896 | 1.0629725087716493e-09 / 3.3335712676585927e-10 | 0.000728 | 2 |
| 399 | CRABP1_1 | 0.0000012003 | 8.712601577854501e-09 / 0.0014562282237067896 | 1.0032588981222376e-06 / 1.6633089557898398e-05 | 0.000728 | 2 |
| 400 | CREB3_1 | 0.0000002396 | 8.712601577854501e-09 / 0.0014562282237067896 | 3.248193062600497e-07 / 1.8160839243636814e-05 | 0.000728 | 2 |
| 401 | CTSB_1 | 0.0000004048 | 0.0014562282237067896 / 8.712601577854501e-09 | 2.7850840733739764e-08 / 6.154886102926167e-07 | 0.000728 | 2 |
| 402 | GLB1_1 | 0.0000009020 | 0.0014562282237067896 / 8.712601577854501e-09 | 5.1549922184344e-09 / 2.2049835157073303e-11 | 0.000728 | 2 |
| 403 | LGALS3_1 | 0.0000001910 | 0.0014562282237067896 / 8.712601577854501e-09 | 3.755610443792837e-07 / 1.150827659828279e-08 | 0.000728 | 2 |
| 404 | SMPD1_1 | 0.0000000902 | 8.712601577854501e-09 / 0.0014562282237067896 | 1.2661160783158677e-07 / 1.5916398320881086e-06 | 0.000728 | 2 |
| 405 | GTPBP4_1 | 0.0000001295 | 0.00028286232014178015 / 0.001443320215490813 | 1.1507531465572511e-05 / 8.380217354744253e-07 | 0.000863 | 2 |
| 406 | ACTR3B_2 | 0.0000000074 | 0.00014435842640211195 / 0.0016167318511468814 | 3.4516372751432266e-05 / 1.6235896245152234e-05 | 0.000881 | 2 |
| 407 | CSRP1_3 | 0.0000000000 | 0.0008963909784287442 / 0.0008703935843289303 | 1.2552190959143249e-05 / 1.0273857961970511e-05 | 0.000883 | 2 |
| 408 | SEPHS1_1 | 0.0000001827 | 0.00173044075017522 / 3.679473658399758e-05 | 8.824502672922857e-06 / 3.0791704702592284e-05 | 0.000884 | 2 |
| 409 | ACTN2_1 | 0.0000008238 | 0.0011231690936696782 / 0.0006456808009902826 | 1.5971362873791044e-06 / 1.6414697658368195e-07 | 0.000884 | 2 |
| 410 | NMRK1_2 | 0.0000000009 | 7.927156138657951e-05 / 0.0016947048583457857 | 1.3825176406826697e-06 / 3.53470906662037e-07 | 0.000887 | 2 |
| 411 | TFAP2A_1 | 0.0000010622 | 0.000397182645222389 / 0.001498796467852237 | 1.6591165825267682e-05 / 3.1676679082128444e-06 | 0.000948 | 2 |
| 412 | CAV1_3 | 0.0000000000 | 0.0017923927195771076 / 0.0001624925597934157 | 1.6411382731391108e-05 / 7.945990872997567e-06 | 0.000977 | 2 |
| 413 | PQLC3_2 | 0.0000004701 | 4.389629454841824e-05 / 0.001937287334836558 | 1.0375195933235037e-08 / 2.8078868409381863e-06 | 0.000991 | 2 |
| 414 | RPL9_4 | 0.0000000000 | 3.781374276352481e-05 / 0.002265806028844651 | 2.8562585574590404e-07 / 1.520546898812959e-06 | 0.001152 | 2 |
| 415 | H2AFY2_3 | 0.0000000000 | 0.0023614039163946366 / 5.479642713695821e-06 | 9.720407948559726e-06 / 2.5274722144655105e-05 | 0.001183 | 2 |
| 416 | MCM10_1 | 0.0000038124 | 0.0021610939865988614 / 0.0004600723635955347 | 1.9111116053257913e-05 / 1.8478236194529347e-06 | 0.001311 | 2 |
| 417 | G6PD_1 | 0.0000098647 | 0.0023157697041580965 / 0.0006256240573576323 | 2.857433835593977e-06 / 2.3724383307219822e-05 | 0.001471 | 2 |
| 418 | TADA1_1 | 0.0000012097 | 0.0026490796375761676 / 0.0004052971561229435 | 3.531944691795736e-06 / 1.881582874926359e-06 | 0.001527 | 2 |
| 419 | KCNC1_5 | 0.0000000000 | 1.8731875907040327e-05 / 0.0031223581236072607 | 7.480602345183493e-06 / 9.900952757251972e-06 | 0.001571 | 2 |
| 420 | JPH4_1 | 0.0000020704 | 0.00037839447623271325 / 0.0028279669089626516 | 1.0663281519153872e-06 / 5.068294298254466e-05 | 0.001603 | 2 |
| 421 | ZNF121_3 | 0.0000000002 | 2.4284932942339803e-06 / 0.0032468305940381815 | 1.097169523033381e-06 / 1.0244293507613468e-05 | 0.001625 | 2 |
| 422 | TMEM206_1 | 0.0000001917 | 0.002859168680149655 / 0.0007069744136606002 | 4.159808093795964e-07 / 7.162200636393188e-06 | 0.001783 | 2 |
| 423 | HS3ST4_1 | 0.0000030972 | 0.0027568341257606386 / 0.0008433274564043463 | 5.152072021912856e-05 / 0.00013189356327001007 | 0.0018 | 2 |
| 424 | MRPL48_1 | 0.0000003952 | 0.0037409240031547972 / 1.2412020538304333e-05 | 0.00010762773346764832 / 5.800656513229227e-07 | 0.001877 | 2 |
| 425 | PPAT_5 | 0.0000000000 | 0.0005240883442637788 / 0.0033630327163844836 | 1.3405009998715396e-07 / 2.0737516222338193e-07 | 0.001944 | 2 |
| 426 | CELF3_3 | 0.0000000012 | 2.6606264463249574e-05 / 0.004048158047358375 | 1.681108063763094e-07 / 6.662779385674438e-06 | 0.002037 | 2 |
| 427 | ABCC8_1 | 0.0000123268 | 0.0005728902408745853 / 0.0037587720790259365 | 2.6233964453337422e-05 / 0.007471621864095462 | 0.002166 | 2 |
| 428 | KIF1C_4 | 0.0000000003 | 0.0032619641963901502 / 0.0011569950059438523 | 8.154868752547337e-07 / 2.557520533005861e-06 | 0.002209 | 2 |
| 429 | MOSPD2_1 | 0.0000012002 | 7.763485144629643e-05 / 0.004557941079021841 | 7.941462431738191e-07 / 1.6722356038590327e-05 | 0.002318 | 2 |
| 430 | ANKRD46_1 | 0.0000009529 | 0.0016555906467057811 / 0.0030838618137353662 | 3.117928478396429e-07 / 1.2106488464901888e-06 | 0.00237 | 2 |
| 431 | RSL24D1_1 | 0.0000003735 | 0.0020456136275657888 / 0.002859168680149655 | 5.740933296039192e-08 / 6.94594888585274e-07 | 0.002452 | 2 |
| 432 | HNRNPC_1 | 0.0000000442 | 0.0003168019030192227 / 0.004613449756294485 | 1.5683726426363387e-05 / 3.1384990249702817e-06 | 0.002465 | 2 |
| 433 | LYST_1 | 0.0000015802 | 0.004613449756294485 / 0.0003168019030192227 | 1.6458786012670833e-07 / 2.821962785745458e-08 | 0.002465 | 2 |
| 434 | MRPS31_2 | 0.0000000065 | 0.004772335371973973 / 0.0003355045145354899 | 3.3355235309279226e-06 / 9.633635724889396e-07 | 0.002554 | 2 |
| 435 | ANXA11_1 | 0.0000056530 | 0.005164155170869671 / 0.0004491267996311823 | 2.916507287390681e-05 / 2.0269807072431288e-06 | 0.002807 | 2 |
| 436 | GABRB3_2 | 0.0000003351 | 0.000506059688566897 / 0.005186853257558283 | 3.096339568332632e-07 / 8.425728705562362e-05 | 0.002846 | 2 |
| 437 | ITGB5_4 | 0.0000000000 | 9.326256093187905e-05 / 0.005791631747081949 | 4.1150806272283625e-06 / 3.579067579944918e-06 | 0.002942 | 2 |
| 438 | TAGLN_5 | 0.0000000000 | 0.0016087657150710478 / 0.004695933649935298 | 1.0747776301357894e-06 / 5.068277336951496e-07 | 0.003152 | 2 |
| 439 | KLF6_1 | 0.0000063009 | 0.000825624209859881 / 0.005675752403043091 | 1.566826366040112e-06 / 2.0575603093756347e-05 | 0.003251 | 2 |
| 440 | GLIS3_1 | 0.0000001584 | 0.0019027179320774803 / 0.004613449756294485 | 8.91146182579548e-08 / 1.1981910549231142e-05 | 0.003258 | 2 |
| 441 | GRPEL2_3 | 0.0000000000 | 0.00010726957614676581 / 0.006720367764597034 | 4.439257342558768e-06 / 8.438825442463246e-05 | 0.003414 | 2 |
| 442 | SORCS1_2 | 0.0000000000 | 8.208006168567451e-05 / 0.007038129780933908 | 7.728334683674074e-07 / 5.209097425595317e-05 | 0.00356 | 2 |
| 443 | TAF3_1 | 0.0000099483 | 0.0013546126949011356 / 0.0060782790336966815 | 1.1902144022027374e-07 / 3.590125727174815e-07 | 0.003716 | 2 |
| 444 | ZNF638_4 | 0.0000000002 | 0.004643194113383492 / 0.002879683794588439 | 1.1731748076272809e-07 / 2.1004419064549084e-06 | 0.003761 | 2 |
| 445 | RPAIN_2 | 0.0000000089 | 0.005656902703414097 / 0.0020182027192515075 | 3.683542119198933e-06 / 5.1931234206185375e-06 | 0.003838 | 2 |
| 446 | PRMT6_2 | 0.0000000762 | 4.9232228985570196e-05 / 0.007808321395428832 | 8.633725399474921e-08 / 1.0594310607660115e-06 | 0.003929 | 2 |
| 447 | CERCAM_1 | 0.0000000458 | 0.007033451966587178 / 0.0011697552308872906 | 2.6140734636276835e-07 / 3.3435498079309047e-05 | 0.004102 | 2 |
| 448 | TWSG1_1 | 0.0000001761 | 6.392429369799613e-05 / 0.008158453075892491 | 5.157744855455523e-08 / 1.1607198631441237e-05 | 0.004111 | 2 |
| 449 | NAP1L1_1 | 0.0000006251 | 0.0009903851658940631 / 0.00741156873832107 | 3.573144437875835e-08 / 2.6755598797458433e-05 | 0.004201 | 2 |
| 450 | NQO2_1 | 0.0000003120 | 0.008488814061362355 / 9.017693290134859e-06 | 2.7731541539595674e-05 / 2.8873360375852757e-06 | 0.004249 | 2 |
| 451 | EXOSC5_1 | 0.0000025109 | 0.0004974933526793384 / 0.008173144283430401 | 7.804789577957665e-13 / 7.74266535906266e-08 | 0.004335 | 2 |
| 452 | LTBP2_1 | 0.0000549802 | 0.0001478074168080298 / 0.008876460493888159 | 0.00010798007651110131 / 4.222343931835182e-06 | 0.004512 | 2 |
| 453 | KIAA1549_3 | 0.0001342161 | 0.0026287641054243034 / 0.006519007047359032 | 7.168411667949609e-07 / 5.5430987684595595e-06 | 0.004574 | 2 |
| 454 | LRP10_2 | 0.0000001825 | 0.005921869111264299 / 0.003413606680030668 | 2.207361096450598e-08 / 3.3470759617279554e-06 | 0.004668 | 2 |
| 455 | CIB1_4 | 0.0000000168 | 0.009433179531708233 / 3.3215427791608696e-05 | 4.2846313000380545e-08 / 3.7292417647649567e-07 | 0.004733 | 2 |
| 456 | RPL19_1 | 0.0000014928 | 0.009179325672229992 / 0.00029389877591584477 | 7.496923788892963e-09 / 2.8239822943662147e-07 | 0.004737 | 2 |
| 457 | CBX2_2 | 0.0000000000 | 4.7075406338787466e-05 / 0.00976885548005096 | 4.131142779946589e-09 / 5.375769141126671e-07 | 0.004908 | 2 |
| 458 | CLVS2_2 | 0.0000001913 | 0.009406082212144616 / 0.0006563295421036791 | 2.5714332068383276e-06 / 5.482716962081155e-06 | 0.005031 | 2 |
| 459 | GLIPR1_2 | 0.0000000000 | 3.466171778138515e-05 / 0.010368022895379076 | 5.654483400792844e-07 / 5.55002977254214e-06 | 0.005201 | 2 |
| 460 | TAPBP_3 | 0.0000000000 | 8.512267986732582e-07 / 0.011323761387770928 | 4.890820513972833e-08 / 6.67431019433855e-06 | 0.005662 | 2 |
| 461 | GNA12_3 | 0.0000000000 | 0.001517583413099564 / 0.009900066282835398 | 6.708969086365922e-07 / 9.569962786694717e-06 | 0.005709 | 2 |
| 462 | MBNL1_1 | 0.0000001024 | 0.002859168680149655 / 0.008597087236259153 | 2.975015241938413e-06 / 0.00015116218032026587 | 0.005728 | 2 |
| 463 | ISYNA1_2 | 0.0000000015 | 0.005657495944434386 / 0.006635836004693275 | 6.464027654347149e-08 / 2.887101958288562e-06 | 0.006147 | 2 |
| 464 | PRLHR_2 | 0.0000005406 | 0.007129272200886299 / 0.0052714519884625305 | 7.77168866368208e-06 / 1.8437240853929896e-05 | 0.0062 | 2 |
| 465 | IQGAP1_5 | 0.0000000000 | 0.012455997462084369 / 1.7523681094523592e-05 | 1.1619283901710663e-08 / 3.139400513751516e-09 | 0.006237 | 2 |
| 466 | SDC4_2 | 0.0000000000 | 3.95395916749111e-05 / 0.012655371032190181 | 4.7350612738275925e-07 / 4.772494328825351e-05 | 0.006347 | 2 |
| 467 | NAA25_1 | 0.0000047407 | 0.0004974933526793384 / 0.012491622786737646 | 8.408015879409482e-10 / 1.1193839755975793e-07 | 0.006495 | 2 |
| 468 | PLEKHA4_1 | 0.0000000554 | 0.012681018200430948 / 0.0008147104901488364 | 4.9420107205779745e-08 / 0.00013683562427249123 | 0.006748 | 2 |
| 469 | TUBA4A_2 | 0.0000001526 | 0.0004894051617618149 / 0.013748845190012026 | 7.439143899721087e-06 / 5.6974125969133664e-05 | 0.007119 | 2 |
| 470 | SLC35D1_1 | 0.0000119741 | 0.0011586570434241133 / 0.01344459083967992 | 7.589908369304536e-05 / 2.286469998615828e-06 | 0.007302 | 2 |
| 471 | SH3GLB1_1 | 0.0000007167 | 0.005409509534570436 / 0.00920357999307954 | 2.215338831755982e-08 / 9.144219102907184e-05 | 0.007307 | 2 |
| 472 | RPL37_1 | 0.0000002993 | 0.00029139375190295606 / 0.014437131210731376 | 1.5481316880518014e-06 / 1.2695577765486368e-06 | 0.007364 | 2 |
| 473 | KDELR3_3 | 0.0000009988 | 0.005599828148522198 / 0.009406629582018086 | 3.321175066033386e-08 / 1.7651037681600008e-10 | 0.007503 | 2 |
| 474 | DDX60L_1 | 0.0000004277 | 0.014968932619439228 / 0.00029139375190295606 | 3.349293334251501e-05 / 3.67192886950216e-06 | 0.00763 | 2 |
| 475 | GNPDA2_1 | 0.0000009111 | 0.012345925407573809 / 0.0029871868526872383 | 1.0139345130923212e-06 / 7.401416660830965e-06 | 0.007667 | 2 |
| 476 | DPY30_1 | 0.0000001493 | 0.01474377883043126 / 0.0008872221356225374 | 8.242352750056853e-06 / 1.0099284699945813e-06 | 0.007816 | 2 |
| 477 | MURC_2 | 0.0000010524 | 0.002464237492576691 / 0.013298076855589635 | 0.00016259523386897824 / 1.28646138088586e-05 | 0.007881 | 2 |
| 478 | CCDC80_2 | 0.0000000780 | 0.007022396430063894 / 0.009406629582018086 | 1.9897144922152364e-08 / 5.96038844248789e-08 | 0.008215 | 2 |
| 479 | C12orf23_1 | 0.0000007686 | 0.007054606953047138 / 0.009406629582018086 | 2.070000126404187e-09 / 3.064830496384329e-08 | 0.008231 | 2 |
| 480 | LOX_1 | 0.0000004721 | 0.007054606953047138 / 0.009406629582018086 | 5.585615326605659e-08 / 2.025993050202001e-07 | 0.008231 | 2 |
| 481 | CEP68_3 | 0.0000000000 | 0.014160855902587557 / 0.0025428536177246916 | 6.659688421576734e-07 / 9.407794731883787e-07 | 0.008352 | 2 |
| 482 | BEND3_1 | 0.0000004060 | 0.015529327313804105 / 0.0013546126949011356 | 1.294856510154241e-07 / 7.843354585243828e-07 | 0.008442 | 2 |
| 483 | RPRD2_3 | 0.0000001192 | 0.0042160036963409305 / 0.013951484913323634 | 3.745187782499438e-06 / 6.105707567166931e-05 | 0.009084 | 2 |
| 484 | ELAVL4_3 | 0.0000000002 | 0.006262584938725883 / 0.012965192074116545 | 1.9990927267649097e-08 / 1.2028673633713268e-05 | 0.009614 | 2 |
| 485 | TRIM21_1 | 0.0000010287 | 0.010532112594999697 / 0.00986299981987636 | 5.27087064977811e-07 / 1.4605266535016458e-05 | 0.010198 | 2 |
| 486 | PRPF40B_1 | 0.0000427258 | 0.017494900781073297 / 0.0030164053071970965 | 1.5471503143081632e-06 / 5.832024795399863e-07 | 0.010256 | 2 |
| 487 | DCLRE1A_1 | 0.0000061634 | 0.004458350846430188 / 0.0169361079209336 | 1.1237015427476724e-07 / 3.0864109406370913e-05 | 0.010697 | 2 |
| 488 | DUSP12_1 | 0.0000017501 | 0.0005152101842532016 / 0.020927835765182444 | 1.3639586195049048e-06 / 3.496306255304265e-05 | 0.010722 | 2 |
| 489 | TFPI_2 | 0.0000000132 | 4.6545402569552315e-05 / 0.02149290799813975 | 4.887360747506771e-06 / 4.0474405834306e-05 | 0.01077 | 2 |
| 490 | MYO1C_2 | 0.0000000121 | 0.017895823171364 / 0.006230846374778002 | 3.081448301668384e-05 / 4.014555294520703e-06 | 0.012063 | 2 |
| 491 | SYDE1_1 | 0.0000000110 | 0.00772762240557102 / 0.016780696985377475 | 1.1653781269953101e-07 / 3.463671891124625e-05 | 0.012254 | 2 |
| 492 | RANBP1_1 | 0.0000003587 | 0.007033451966587178 / 0.018278644383879286 | 1.8768112225438676e-06 / 2.385161536231052e-05 | 0.012656 | 2 |
| 493 | PRAME_3 | 0.0000000000 | 0.00027122572057250454 / 0.02549151253917823 | 7.315372425838117e-07 / 0.0043647330554926495 | 0.012881 | 2 |
| 494 | PNN_1 | 0.0000004953 | 0.023632426585188764 / 0.0037180700854572363 | 1.567862197944385e-05 / 1.9432605539900083e-06 | 0.013675 | 2 |
| 495 | PHF11_3 | 0.0000000000 | 0.0199742851386832 / 0.0074443763066621635 | 2.2460867352749832e-05 / 4.034050219148119e-05 | 0.013709 | 2 |
| 496 | WDR35_1 | 0.0000956275 | 0.00595365839866055 / 0.022259394060437563 | 2.301536456666849e-08 / 4.7905231342002456e-05 | 0.014107 | 2 |
| 497 | KCNN4_5 | 0.0000000000 | 0.028325850554739726 / 1.0422333032628909e-05 | 4.2230909676496135e-06 / 6.214193085118779e-08 | 0.014168 | 2 |
| 498 | SERPINB6_1 | 0.0000000860 | 0.02111164899698619 / 0.007725328433277938 | 2.187431797229529e-06 / 2.509158352753995e-06 | 0.014418 | 2 |
| 499 | ACOT9_5 | 0.0000000000 | 8.858145837069308e-06 / 0.02928133094687868 | 1.4274535341490866e-06 / 1.1707897663572821e-05 | 0.014645 | 2 |
| 500 | LAMP1_2 | 0.0000000008 | 0.030054976866849478 / 8.732445306306717e-05 | 5.466481696938671e-06 / 1.5820496858297314e-06 | 0.015071 | 2 |
| 501 | C19orf10_2 | 0.0000012073 | 0.007022396430063894 / 0.02370242637699958 | 1.3938096456595192e-06 / 3.106836436822797e-06 | 0.015362 | 2 |
| 502 | EHD2_1 | 0.0000051889 | 0.006387086743044337 / 0.024359073362915318 | 3.1581541925072244e-08 / 6.252023917064675e-07 | 0.015373 | 2 |
| 503 | DPH5_1 | 0.0000000253 | 0.005268014147815726 / 0.025798539904455884 | 7.65363618891567e-06 / 2.5443259723878794e-07 | 0.015533 | 2 |
| 504 | TMEM169_1 | 0.0000042184 | 0.015328857071669418 / 0.01613036709497828 | 5.271735025959501e-06 / 7.657861944466996e-06 | 0.01573 | 2 |
| 505 | SMARCB1_1 | 0.0000002644 | 0.02077959376727299 / 0.011174729900658115 | 8.011755580473669e-08 / 3.2615951234563365e-06 | 0.015977 | 2 |
| 506 | PLEKHF2_1 | 0.0000084591 | 0.030555512760793904 / 0.0019120019643383967 | 6.139203454059454e-06 / 1.7597453128430795e-05 | 0.016234 | 2 |
| 507 | HSF2_5 | 0.0000000024 | 0.0011883468549077506 / 0.032054869676694284 | 3.40227203271683e-05 / 0.00014757007119292403 | 0.016622 | 2 |
| 508 | ASPH_1 | 0.0000002995 | 0.033538144332397844 / 0.00028614552404424633 | 5.685936788307393e-09 / 9.429685991450496e-08 | 0.016912 | 2 |
| 509 | SERINC3_1 | 0.0000008790 | 0.033538144332397844 / 0.00028614552404424633 | 2.49764511508294e-09 / 1.134358362342082e-07 | 0.016912 | 2 |
| 510 | THOC5_1 | 0.0000003036 | 0.013135303284974763 / 0.02077959376727299 | 2.342665333258182e-05 / 2.6803490912759556e-06 | 0.016957 | 2 |
| 511 | SLC6A15_1 | 0.0000005833 | 0.004726766888964287 / 0.029245906890336886 | 3.0205657665658226e-07 / 1.9753690366539358e-07 | 0.016986 | 2 |
| 512 | TBC1D2_1 | 0.0000051878 | 0.0026971498523362084 / 0.03142306493318558 | 2.36394903321324e-07 / 3.4669139065625866e-06 | 0.01706 | 2 |
| 513 | HSPG2_1 | 0.0000035348 | 0.005508211750735854 / 0.029004639226340192 | 3.456379747077034e-08 / 1.3650260422668218e-06 | 0.017256 | 2 |
| 514 | CACNA2D2_1 | 0.0000002397 | 0.012989035651382866 / 0.0220527090420233 | 9.84795387151116e-07 / 0.00014763731434387815 | 0.017521 | 2 |
| 515 | SLC5A6_2 | 0.0000000011 | 6.726351690377188e-06 / 0.03632726905839838 | 3.564147772687014e-09 / 2.3833706506813445e-08 | 0.018167 | 2 |
| 516 | DAZAP1_2 | 0.0000010886 | 0.035346052334371256 / 0.0020041144974840427 | 6.336641396851863e-06 / 2.7162116297049073e-06 | 0.018675 | 2 |
| 517 | NFIX_2 | 0.0000470223 | 0.034278763403653136 / 0.004363119893312578 | 3.742274946692005e-08 / 8.621152000254767e-06 | 0.019321 | 2 |
| 518 | ELAVL3_3 | 0.0000002367 | 0.032717168309564344 / 0.00603260340463039 | 5.233156358088248e-08 / 1.2259141243737108e-05 | 0.019375 | 2 |
| 519 | COPB2_1 | 0.0000009988 | 0.030556265901493518 / 0.009461453275903385 | 7.7726596868819e-09 / 1.2483359571678263e-07 | 0.020009 | 2 |
| 520 | ZNF219_1 | 0.0000201928 | 0.0013753510178836541 / 0.040351165135619635 | 4.130137554486895e-08 / 8.551025528226429e-06 | 0.020863 | 2 |
| 521 | RNF165_2 | 0.0000000071 | 0.00045689445671322015 / 0.04290525645291146 | 4.007091987107082e-07 / 5.771520423008575e-06 | 0.021681 | 2 |
| 522 | P4HA1_1 | 0.0000001230 | 0.03388354547402121 / 0.009805971532350915 | 0.0006317756731189806 / 1.426894913839978e-05 | 0.021845 | 2 |
| 523 | CIB2_3 | 0.0000052976 | 0.03149060869705135 / 0.012259451329060318 | 9.024424890774902e-07 / 1.0442027429124592e-07 | 0.021875 | 2 |
| 524 | LMAN2_1 | 0.0000170444 | 0.01903033340546255 / 0.025082579510674555 | 7.009613011978967e-07 / 2.5751189172533023e-06 | 0.022056 | 2 |
| 525 | POFUT1_1 | 0.0000072701 | 0.001142587490178054 / 0.043241971329782115 | 7.112620349907573e-07 / 1.1322431164545276e-05 | 0.022192 | 2 |
| 526 | ITGB1_1 | 0.0000003907 | 0.02269898054008244 / 0.0248532779265148 | 7.3505722166603895e-09 / 1.5385068037778083e-08 | 0.023776 | 2 |
| 527 | GFPT2_2 | 0.0000000000 | 0.04814570015405706 / 9.938212812133593e-06 | 1.3739713879197712e-06 / 1.5888765178369776e-06 | 0.024078 | 2 |
| 528 | SNTB2_2 | 0.0000013898 | 0.00045763370789409137 / 0.04798455655539519 | 4.937390910049744e-08 / 1.0481483686547674e-06 | 0.024221 | 2 |
| 529 | FAM126A_1 | 0.0000076004 | 0.008114330308262623 / 0.043466125038867966 | 6.442446565574853e-07 / 7.404414626788326e-07 | 0.02579 | 2 |
| 530 | FAM214B_1 | 0.0000010912 | 0.007767111012470563 / 0.04394971982153738 | 9.766150972459384e-09 / 5.811940190116354e-06 | 0.025858 | 2 |
| 531 | E2F5_1 | 0.0000013604 | 0.049711930848541044 / 0.0033175174072552346 | 4.003267630664399e-07 / 9.866737749751602e-07 | 0.026515 | 2 |
| 532 | CRMP1_1 | 0.0000084591 | 0.017443397981769932 / 0.03683753470884825 | 8.413742944743679e-07 / 4.106621117381678e-06 | 0.02714 | 2 |
| 533 | DTX3L_1 | 0.0000084583 | 0.03683753470884825 / 0.017443397981769932 | 6.797147151581183e-07 / 1.417692420229351e-07 | 0.02714 | 2 |
| 534 | ELAVL3_1 | 0.0000001607 | 0.03683753470884825 / 0.017443397981769932 | 1.3771030020123217e-07 / 1.1898412039254247e-06 | 0.02714 | 2 |
| 535 | GATA2_1 | 0.0000032251 | 0.017443397981769932 / 0.03683753470884825 | 2.379056852862588e-07 / 7.419739232422929e-07 | 0.02714 | 2 |
| 536 | GNG4_1 | 0.0000011175 | 0.017443397981769932 / 0.03683753470884825 | 2.833288980358075e-07 / 3.0194192839021757e-06 | 0.02714 | 2 |
| 537 | GPX8_1 | 0.0000018792 | 0.017443397981769932 / 0.03683753470884825 | 1.1126780547850324e-07 / 3.7460365163269813e-07 | 0.02714 | 2 |
| 538 | LATS2_1 | 0.0000002146 | 0.017443397981769932 / 0.03683753470884825 | 8.009574761254957e-07 / 7.564366651535585e-06 | 0.02714 | 2 |
| 539 | TMEM87B_1 | 0.0000035381 | 0.046460374349346606 / 0.00986299981987636 | 2.2083608853369944e-06 / 2.6000415048116556e-06 | 0.028162 | 2 |
| 540 | NR2C1_1 | 0.0000011174 | 0.049070601469191656 / 0.00773983756525658 | 1.016347019186649e-05 / 2.9570254790683987e-05 | 0.028405 | 2 |
| 541 | CHMP4B_1 | 0.0000228401 | 0.023755415081211387 / 0.03496487724871062 | 7.568402263460558e-06 / 1.602695870510606e-06 | 0.02936 | 2 |
| 542 | HPDL_1 | 0.0000326628 | 0.04277794935005184 / 0.01886546643390927 | 2.946919779060583e-07 / 2.526544471155658e-06 | 0.030822 | 2 |
| 543 | HNRPDL_1 | 0.0000017461 | 0.029245906890336886 / 0.03496385796284249 | 5.094906510060717e-06 / 0.0005450663768553773 | 0.032105 | 2 |
| 544 | MICB_1 | 0.0000005886 | 0.03856382315007413 / 0.030649533557856844 | 3.2225183304348016e-07 / 2.082657792499939e-05 | 0.034607 | 2 |
| 545 | C17orf53_5 | 0.0056512849 | 0.03313812387988766 / 0.0369823965122664 | 1.7766971737416816e-07 / 4.945807676396787e-08 | 0.03506 | 2 |
| 546 | WDR3_1 | 0.0000063135 | 0.038526552055961574 / 0.033508173499253606 | 1.3194741430704085e-06 / 5.999026130299875e-08 | 0.036017 | 2 |
| 547 | FKBP15_1 | 0.0000015165 | 0.038665976753680685 / 0.037764618743349666 | 1.938771779561528e-07 / 8.867393316201706e-07 | 0.038215 | 2 |
| 548 | SLC22A23_1 | 0.0000002831 | 8.712601577854501e-09 | 1.4395456175321122e-06 | 8.71E-09 | 1 |
| 549 | ST6GALNAC3_1 | 0.0000002679 | 8.712601577854501e-09 | 1.7157900523441861e-07 | 8.71E-09 | 1 |
| 550 | RCAN1_3 | 0.0000000016 | 3.499510929936492e-08 | 1.26835830581151e-07 | 3.5E-08 | 1 |
| 551 | CCDC107_2 | 0.0000000001 | 6.395893878746714e-08 | 9.461935060607236e-07 | 6.4E-08 | 1 |
| 552 | PAX6_2 | 0.0000000009 | 7.077258149360326e-07 | 9.972664897230697e-08 | 7.08E-07 | 1 |
| 553 | IGSF9_5 | 0.0000000004 | 1.1979104163692412e-06 | 8.265188982147678e-06 | 1.2E-06 | 1 |
| 554 | TFAP4_2 | 0.0000000085 | 2.321730111153503e-06 | 1.7564281952911052e-07 | 2.32E-06 | 1 |
| 555 | B2M_5 | 0.0000000000 | 2.8861862169068284e-06 | 4.480381749486679e-06 | 2.89E-06 | 1 |
| 556 | ZCCHC12_1 | 0.0000002526 | 3.027796588478565e-06 | 3.463674540195252e-08 | 3.03E-06 | 1 |
| 557 | MYL12B_3 | 0.0000000860 | 3.036941140125125e-06 | 1.4602780290417217e-05 | 3.04E-06 | 1 |
| 558 | SHPRH_5 | 0.0000000003 | 5.230619502812216e-06 | 2.937677082211747e-07 | 5.23E-06 | 1 |
| 559 | NRSN1_4 | 0.0000000000 | 5.476196107524447e-06 | 2.997579133447394e-06 | 5.48E-06 | 1 |
| 560 | HNRNPR_3 | 0.0000000000 | 5.558921390245165e-06 | 3.126649204411196e-06 | 5.56E-06 | 1 |
| 561 | RRAGC_2 | 0.0000000001 | 5.618452957713235e-06 | 9.311046175034272e-06 | 5.62E-06 | 1 |
| 562 | CTSA_3 | 0.0000000013 | 6.56608104779876e-06 | 2.506639438406534e-09 | 6.57E-06 | 1 |
| 563 | DUSP26_3 | 0.0000000000 | 7.058822532691102e-06 | 4.827489564324781e-06 | 7.06E-06 | 1 |
| 564 | IFI35_2 | 0.0000000001 | 7.334382821279422e-06 | 3.030479316814345e-07 | 7.33E-06 | 1 |
| 565 | FAM163A_4 | 0.0000000000 | 9.356029087940393e-06 | 1.1664211635226015e-06 | 9.36E-06 | 1 |
| 566 | DHX15_3 | 0.0000000002 | 9.568251410073365e-06 | 2.403428814770779e-07 | 9.57E-06 | 1 |
| 567 | WDR86_3 | 0.0000000000 | 1.0462572531149967e-05 | 5.73499996685614e-06 | 1.05E-05 | 1 |
| 568 | CECR5_1 | 0.0000003529 | 1.2412020538304333e-05 | 8.265652927676646e-07 | 1.24E-05 | 1 |
| 569 | VASH2_1 | 0.0000000292 | 1.2412020538304333e-05 | 2.7260938912368544e-09 | 1.24E-05 | 1 |
| 570 | KCNH8_2 | 0.0000000001 | 1.3893428326375037e-05 | 1.025651613746495e-06 | 1.39E-05 | 1 |
| 571 | MRPS25_3 | 0.0000000000 | 1.4962982992013249e-05 | 5.883502199500679e-05 | 1.5E-05 | 1 |
| 572 | COPS7B_4 | 0.0000000000 | 1.9055379659727616e-05 | 1.8406897134601384e-06 | 1.91E-05 | 1 |
| 573 | PHYHIPL_2 | 0.0000000044 | 1.9765992682251932e-05 | 7.662073328952884e-08 | 1.98E-05 | 1 |
| 574 | ATP6V0E1_3 | 0.0000000000 | 2.1199783161506686e-05 | 3.178350125115292e-06 | 2.12E-05 | 1 |
| 575 | CEP44_5 | 0.0000000000 | 2.6817088180208884e-05 | 3.075797968981328e-07 | 2.68E-05 | 1 |
| 576 | SEC22C_1 | 0.0000126263 | 3.772462305351297e-05 | 2.5473717020986836e-06 | 3.77E-05 | 1 |
| 577 | TRIM38_2 | 0.0000000010 | 4.232307256197528e-05 | 9.004771302620853e-07 | 4.23E-05 | 1 |
| 578 | MTF2_1 | 0.0000003729 | 4.778480179883678e-05 | 3.677618476819043e-06 | 4.78E-05 | 1 |
| 579 | ZC3H15_4 | 0.0000000000 | 4.99139389651813e-05 | 8.062168588983905e-05 | 4.99E-05 | 1 |
| 580 | THOC5_2 | 0.0000000078 | 5.370663550005663e-05 | 9.265177499664469e-07 | 5.37E-05 | 1 |
| 581 | CLASP2_2 | 0.0000000009 | 5.412804644102036e-05 | 3.7830870595223054e-07 | 5.41E-05 | 1 |
| 582 | SLC18A2_2 | 0.0000000045 | 5.6390218253045825e-05 | 1.7279928388791176e-05 | 5.64E-05 | 1 |
| 583 | NDUFAF4_4 | 0.0000000000 | 5.8700155983793994e-05 | 2.5189349324309824e-08 | 5.87E-05 | 1 |
| 584 | CHD4_1 | 0.0000002613 | 6.392429369799613e-05 | 4.5917357478734616e-10 | 6.39E-05 | 1 |
| 585 | KIF5A_3 | 0.0000000388 | 6.823910763393263e-05 | 2.8021219460869213e-07 | 6.82E-05 | 1 |
| 586 | CNN2_2 | 0.0000000049 | 7.667846295453872e-05 | 4.936771116007079e-06 | 7.67E-05 | 1 |
| 587 | DCBLD1_2 | 0.0000000000 | 7.734573702217467e-05 | 2.622737549604328e-07 | 7.73E-05 | 1 |
| 588 | SPSB4_2 | 0.0000000009 | 7.736803917574157e-05 | 1.665549189503519e-06 | 7.74E-05 | 1 |
| 589 | EDIL3_1 | 0.0000003533 | 7.763485144629643e-05 | 2.106653942117265e-06 | 7.76E-05 | 1 |
| 590 | GALNT10_3 | 0.0000000000 | 8.677918268232137e-05 | 8.482412543283543e-07 | 8.68E-05 | 1 |
| 591 | H1FX_1 | 0.0000006013 | 9.000996792266372e-05 | 3.1636024561990265e-07 | 9E-05 | 1 |
| 592 | OSGIN1_4 | 0.0000001415 | 9.283230157343638e-05 | 1.9657683205901488e-07 | 9.28E-05 | 1 |
| 593 | PRRX1_1 | 0.0000004579 | 9.464090281065672e-05 | 3.3589212783746634e-09 | 9.46E-05 | 1 |
| 594 | SERF2_1 | 0.0000008582 | 9.559019073817654e-05 | 3.4428228168417093e-07 | 9.56E-05 | 1 |
| 595 | PPP1CC_3 | 0.0000000001 | 9.749181327114085e-05 | 1.7389165234639967e-07 | 9.75E-05 | 1 |
| 596 | SYDE1_2 | 0.0000000598 | 0.00010643560926875712 | 1.503089017990499e-07 | 0.000106 | 1 |
| 597 | C11orf74_2 | 0.0000000007 | 0.00010744642656817331 | 1.4631867053999944e-05 | 0.000107 | 1 |
| 598 | NEFH_1 | 0.0000000473 | 0.00011095297992729127 | 1.5371136619548915e-05 | 0.000111 | 1 |
| 599 | MPPE1_2 | 0.0000000746 | 0.00011144654065968228 | 1.6486688003824867e-06 | 0.000111 | 1 |
| 600 | RAC3_1 | 0.0000011018 | 0.00012418009082273935 | 4.416840433956102e-05 | 0.000124 | 1 |
| 601 | XRCC2_1 | 0.0000063155 | 0.0001281986995674009 | 2.3117725678541128e-08 | 0.000128 | 1 |
| 602 | PVRL2_2 | 0.0000000002 | 0.00013157696997892983 | 1.9665782290909765e-07 | 0.000132 | 1 |
| 603 | JAKMIP1_3 | 0.0000000000 | 0.0001624284911175795 | 1.3322851721010925e-05 | 0.000162 | 1 |
| 604 | RETSAT_2 | 0.0000000021 | 0.00018285567959994966 | 2.2405276167100574e-05 | 0.000183 | 1 |
| 605 | ECSIT_4 | 0.0000000000 | 0.00023954975788706846 | 7.566489045169451e-08 | 0.00024 | 1 |
| 606 | KCTD11_5 | 0.0000000000 | 0.0002424331083574083 | 3.522356648205783e-06 | 0.000242 | 1 |
| 607 | NOL4_1 | 0.0000000729 | 0.0002459835698877307 | 6.791821030730467e-07 | 0.000246 | 1 |
| 608 | PHACTR3_1 | 0.0000000457 | 0.0002459835698877307 | 0.00011686809560116665 | 0.000246 | 1 |
| 609 | RTN1_1 | 0.0000006098 | 0.0002459835698877307 | 4.222711647559608e-07 | 0.000246 | 1 |
| 610 | STMN2_1 | 0.0000012964 | 0.0002459835698877307 | 4.094884978838306e-05 | 0.000246 | 1 |
| 611 | AP2S1_2 | 0.0000000002 | 0.0002471622654017496 | 1.0198622949899072e-05 | 0.000247 | 1 |
| 612 | ZFYVE21_1 | 0.0000194549 | 0.00025234279143195943 | 5.133817635619759e-06 | 0.000252 | 1 |
| 613 | UNC13A_1 | 0.0000014726 | 0.00028614552404424633 | 2.0145584910723037e-05 | 0.000286 | 1 |
| 614 | HRH3_2 | 0.0000000245 | 0.00028947620258979817 | 6.225133521987448e-05 | 0.000289 | 1 |
| 615 | SLC46A3_1 | 0.0000004395 | 0.00029139375190295606 | 3.1273990762894294e-06 | 0.000291 | 1 |
| 616 | FANCF_1 | 0.0000011239 | 0.00029389877591584477 | 0.00014597857403495873 | 0.000294 | 1 |
| 617 | NUP188_1 | 0.0000001812 | 0.0003007412862887539 | 4.955407744532583e-06 | 0.000301 | 1 |
| 618 | RASL11B_4 | 0.0000000000 | 0.00031499165163320023 | 4.227422993905127e-06 | 0.000315 | 1 |
| 619 | RPL35A_1 | 0.0000009189 | 0.0003258993441790789 | 7.814046683768043e-08 | 0.000326 | 1 |
| 620 | MRPS34_2 | 0.0000000002 | 0.0003472766416957016 | 2.882909993280601e-07 | 0.000347 | 1 |
| 621 | GIMAP2_3 | 0.0000000036 | 0.0003570706360030332 | 0.00045579260491531034 | 0.000357 | 1 |
| 622 | CEP290_2 | 0.0000000344 | 0.00037108570224806444 | 2.0125145944135785e-07 | 0.000371 | 1 |
| 623 | GLTPD1_2 | 0.0000000118 | 0.0003718951957804949 | 0.0006320584367733676 | 0.000372 | 1 |
| 624 | GPHN_2 | 0.0000000007 | 0.0003773923191660758 | 5.22047699300538e-06 | 0.000377 | 1 |
| 625 | CASP1_1 | 0.0000000068 | 0.00037839447623271325 | 6.1495186991073225e-09 | 0.000378 | 1 |
| 626 | ZNF696_1 | 0.0000000962 | 0.00037839447623271325 | 2.4615255354876653e-06 | 0.000378 | 1 |
| 627 | PUM2_1 | 0.0000026305 | 0.0003816779304374477 | 3.3222971313684545e-07 | 0.000382 | 1 |
| 628 | MEIS1_3 | 0.0000004107 | 0.0003904462676161654 | 0.0007682186961292422 | 0.00039 | 1 |
| 629 | IFI30_1 | 0.0000012163 | 0.00040506375286474184 | 9.574423734042937e-07 | 0.000405 | 1 |
| 630 | IL11RA_1 | 0.0000001170 | 0.0004052971561229435 | 2.655673357753088e-06 | 0.000405 | 1 |
| 631 | NUCB2_1 | 0.0000013611 | 0.0004052971561229435 | 5.5618984098014e-07 | 0.000405 | 1 |
| 632 | PTP4A3_1 | 0.0000000680 | 0.0004052971561229435 | 5.887768664427049e-08 | 0.000405 | 1 |
| 633 | ADRBK2_2 | 0.0000000000 | 0.0004093391300622974 | 1.5783568509062198e-06 | 0.000409 | 1 |
| 634 | PKIG_3 | 0.0000000000 | 0.00041171580743841403 | 3.057193996659834e-08 | 0.000412 | 1 |
| 635 | SET_2 | 0.0000000001 | 0.0004229662691805196 | 1.4462314562288453e-05 | 0.000423 | 1 |
| 636 | FLII_4 | 0.0000000000 | 0.000424309729157916 | 2.721972050662147e-05 | 0.000424 | 1 |
| 637 | ARF6_1 | 0.0000010688 | 0.00044644151159829265 | 4.777162467883633e-05 | 0.000446 | 1 |
| 638 | HMGCR_1 | 0.0000039108 | 0.0004491267996311823 | 9.51430189572535e-06 | 0.000449 | 1 |
| 639 | ST8SIA3_1 | 0.0000019568 | 0.0004491267996311823 | 4.900547697748023e-06 | 0.000449 | 1 |
| 640 | UNC80_1 | 0.0000008226 | 0.0004491267996311823 | 1.005782022353512e-07 | 0.000449 | 1 |
| 641 | CCT8_3 | 0.0000000347 | 0.00045011610035894004 | 2.032003598923382e-06 | 0.00045 | 1 |
| 642 | TRIM28_1 | 0.0000148486 | 0.00045014028192995044 | 3.949110489775901e-06 | 0.00045 | 1 |
| 643 | CDC25A_2 | 0.0000000098 | 0.0004534776514099725 | 1.5512971032931264e-06 | 0.000453 | 1 |
| 644 | GLTP_2 | 0.0000000028 | 0.00046494643788992516 | 5.8185552156116945e-06 | 0.000465 | 1 |
| 645 | CCDC77_1 | 0.0000004612 | 0.0004974933526793384 | 4.507699749268401e-07 | 0.000497 | 1 |
| 646 | MCF2L_1 | 0.0000000690 | 0.0005027123562350216 | 7.202072224189724e-07 | 0.000503 | 1 |
| 647 | SLC6A2_2 | 0.0000001185 | 0.000506059688566897 | 2.28692972901338e-08 | 0.000506 | 1 |
| 648 | SYP_2 | 0.0000001356 | 0.000506059688566897 | 6.3185873271940225e-06 | 0.000506 | 1 |
| 649 | CNOT6_1 | 0.0000013898 | 0.0005152101842532016 | 1.3714419618221151e-06 | 0.000515 | 1 |
| 650 | VARS_1 | 0.0000000157 | 0.0005152101842532016 | 6.389630116189804e-11 | 0.000515 | 1 |
| 651 | IFITM3_4 | 0.0000000000 | 0.0005174358092289639 | 1.9647037009697173e-05 | 0.000517 | 1 |
| 652 | PEX5_1 | 0.0000022882 | 0.0005345944155461007 | 2.4708316986247094e-07 | 0.000535 | 1 |
| 653 | SLC31A2_2 | 0.0000000257 | 0.0005474521677410701 | 1.2568064895404654e-06 | 0.000547 | 1 |
| 654 | GRIK3_1 | 0.0000076075 | 0.0005728902408745853 | 5.005291812592071e-05 | 0.000573 | 1 |
| 655 | VN1R1_1 | 0.0000028939 | 0.0006456808009902826 | 1.5945573929220053e-06 | 0.000646 | 1 |
| 656 | TFB2M_1 | 0.0000001636 | 0.0006554884190714251 | 8.29128842666871e-07 | 0.000655 | 1 |
| 657 | MAD2L1_1 | 0.0000002657 | 0.000678865345560909 | 0.00022984708856661868 | 0.000679 | 1 |
| 658 | MCM7_1 | 0.0000003921 | 0.000678865345560909 | 2.3157502863099238e-08 | 0.000679 | 1 |
| 659 | MLF1IP_1 | 0.0000001155 | 0.000678865345560909 | 1.6356325391481808e-06 | 0.000679 | 1 |
| 660 | RFC3_1 | 0.0000001961 | 0.000678865345560909 | 1.1405622586556333e-05 | 0.000679 | 1 |
| 661 | RPL13A_5 | 0.0000000036 | 0.0006975780500730752 | 2.039076211055246e-07 | 0.000698 | 1 |
| 662 | LINGO2_5 | 0.0000000000 | 0.0007331284191550658 | 3.7702692631153038e-06 | 0.000733 | 1 |
| 663 | DNAJC22_1 | 0.0000621331 | 0.0007382242549827655 | 0.000384678461175607 | 0.000738 | 1 |
| 664 | LAPTM4B_5 | 0.0000000199 | 0.0008008831004583888 | 1.799793994988323e-08 | 0.000801 | 1 |
| 665 | MRPL21_1 | 0.0000002469 | 0.000813643911578377 | 2.155726402205982e-11 | 0.000814 | 1 |
| 666 | KBTBD6_5 | 0.0000000012 | 0.0008752905126922217 | 5.094541684026646e-07 | 0.000875 | 1 |
| 667 | ENDOD1_1 | 0.0000010618 | 0.0009656194251740187 | 1.0198902416156784e-06 | 0.000966 | 1 |
| 668 | DYNLT3_1 | 0.0000002295 | 0.0009791477447292118 | 3.4005766399654322e-06 | 0.000979 | 1 |
| 669 | FBXO33_3 | 0.0000001392 | 0.00103117959256628 | 0.0005017044994385344 | 0.001031 | 1 |
| 670 | MAGT1_3 | 0.0000000006 | 0.0011183473761450665 | 3.282773317248208e-06 | 0.001118 | 1 |
| 671 | RAP2C_1 | 0.0000000589 | 0.0012216917856767418 | 2.1738080076458742e-06 | 0.001222 | 1 |
| 672 | UNC13A_4 | 0.0000000000 | 0.0012433758358174857 | 1.4243994675867104e-05 | 0.001243 | 1 |
| 673 | MFAP5_1 | 0.0000031279 | 0.0012466841325621532 | 3.1380128368492257e-06 | 0.001247 | 1 |
| 674 | CUX2_2 | 0.0000000011 | 0.001257136009743649 | 7.431311834991675e-07 | 0.001257 | 1 |
| 675 | MED25_5 | 0.0000000204 | 0.001313200027316744 | 1.4936727700519996e-05 | 0.001313 | 1 |
| 676 | MYT1L_2 | 0.0000000108 | 0.0013890971495074075 | 1.0025847658579697e-06 | 0.001389 | 1 |
| 677 | TMEM18_2 | 0.0000076695 | 0.0013942235684900853 | 1.707287632066412e-07 | 0.001394 | 1 |
| 678 | CCT7_1 | 0.0000001734 | 0.001443320215490813 | 1.1968773859770425e-09 | 0.001443 | 1 |
| 679 | MAK16_1 | 0.0000004814 | 0.001443320215490813 | 2.3072064933343512e-09 | 0.001443 | 1 |
| 680 | MRPS21_1 | 0.0000000540 | 0.001443320215490813 | 6.719016265932361e-09 | 0.001443 | 1 |
| 681 | POLR1B_1 | 0.0000003351 | 0.001443320215490813 | 1.7793565095841775e-08 | 0.001443 | 1 |
| 682 | GTPBP1_2 | 0.0000000021 | 0.001459680524809358 | 0.00015614452037923833 | 0.00146 | 1 |
| 683 | EBF3_1 | 0.0000010072 | 0.0014691176249919573 | 8.044891819455788e-07 | 0.001469 | 1 |
| 684 | MTUS1_2 | 0.0000935307 | 0.0015509534579936969 | 1.105438193098732e-06 | 0.001551 | 1 |
| 685 | NUP133_2 | 0.0000000014 | 0.0015899100236963135 | 1.3303993388626396e-05 | 0.00159 | 1 |
| 686 | CTNND1_2 | 0.0000000000 | 0.001732526914901912 | 3.072309330628804e-05 | 0.001733 | 1 |
| 687 | NDUFB9_1 | 0.0000000238 | 0.0017523496068642189 | 5.3915212453729005e-09 | 0.001752 | 1 |
| 688 | SLC9A7_1 | 0.0000003133 | 0.0017523496068642189 | 1.2535099503914342e-05 | 0.001752 | 1 |
| 689 | EIF4ENIF1_1 | 0.0000108333 | 0.0017678348648425643 | 3.7197697739906752e-06 | 0.001768 | 1 |
| 690 | DOCK1_1 | 0.0000181948 | 0.001772102755233229 | 1.4070332453720584e-06 | 0.001772 | 1 |
| 691 | RPL32_1 | 0.0000022322 | 0.001777378099890663 | 6.225050246986396e-05 | 0.001777 | 1 |
| 692 | PRICKLE2_1 | 0.0000006847 | 0.0018473350729729212 | 2.0385221521213067e-05 | 0.001847 | 1 |
| 693 | RUFY3_1 | 0.0000070188 | 0.0018473350729729212 | 1.8701260489318547e-05 | 0.001847 | 1 |
| 694 | WNT5A_1 | 0.0000028497 | 0.0018473350729729212 | 2.708727992064078e-06 | 0.001847 | 1 |
| 695 | MPHOSPH10_2 | 0.0000000007 | 0.0018678908445817427 | 1.5239795553355398e-06 | 0.001868 | 1 |
| 696 | ARID3A_1 | 0.0000002399 | 0.0019027179320774803 | 5.715891598653691e-07 | 0.001903 | 1 |
| 697 | HBQ1_1 | 0.0000006406 | 0.0019027179320774803 | 6.157621558231056e-07 | 0.001903 | 1 |
| 698 | CAPG_5 | 0.0000000000 | 0.001947090513575717 | 7.749723393890698e-06 | 0.001947 | 1 |
| 699 | YARS2_2 | 0.0005979379 | 0.0019907006334396776 | 5.679834094373692e-07 | 0.001991 | 1 |
| 700 | KIAA0247_5 | 0.0000000008 | 0.001994915026343904 | 7.399520670189372e-07 | 0.001995 | 1 |
| 701 | ATP6V1A_1 | 0.0000002721 | 0.0020456136275657888 | 5.629476223876873e-08 | 0.002046 | 1 |
| 702 | NFXL1_3 | 0.0000000000 | 0.0020758764777589786 | 5.099976094773998e-07 | 0.002076 | 1 |
| 703 | RIOK3_3 | 0.0000000003 | 0.0021500812901470065 | 0.00030023156807518783 | 0.00215 | 1 |
| 704 | AKR7A2_4 | 0.0000000023 | 0.0021553658383185563 | 2.358890665005359e-05 | 0.002155 | 1 |
| 705 | THOC1_3 | 0.0000009047 | 0.002194182322111777 | 0.00021664763805975321 | 0.002194 | 1 |
| 706 | COPG_1 | 0.0000003427 | 0.0021961385175434875 | 8.880302868410324e-08 | 0.002196 | 1 |
| 707 | RPL13_1 | 0.0000004776 | 0.002391299161389133 | 4.361906742412738e-06 | 0.002391 | 1 |
| 708 | ARRB2_2 | 0.0000000003 | 0.0024223436617129856 | 8.170313945294133e-05 | 0.002422 | 1 |
| 709 | CCDC41_2 | 0.0000005081 | 0.0024621645703630526 | 1.7620046187445725e-05 | 0.002462 | 1 |
| 710 | WDR75_5 | 0.0000000001 | 0.0024742390938208743 | 2.813266963497791e-07 | 0.002474 | 1 |
| 711 | LRBA_4 | 0.0000000000 | 0.002519709257235862 | 0.0002137598179932144 | 0.00252 | 1 |
| 712 | BAI3_2 | 0.0000000007 | 0.002579529817958645 | 3.1862597515464765e-08 | 0.00258 | 1 |
| 713 | FKBP4_1 | 0.0000009273 | 0.0026665845796536394 | 3.954836683246733e-07 | 0.002667 | 1 |
| 714 | H3F3B_1 | 0.0000006090 | 0.0026665845796536394 | 1.0621184124507563e-07 | 0.002667 | 1 |
| 715 | LRRC45_1 | 0.0000035848 | 0.002695070404947365 | 0.005476743217592932 | 0.002695 | 1 |
| 716 | VPRBP_1 | 0.0000098159 | 0.0028451265399304145 | 0.00033046637508825843 | 0.002845 | 1 |
| 717 | KIF1A_1 | 0.0000002287 | 0.002859168680149655 | 7.313472575923523e-07 | 0.002859 | 1 |
| 718 | RPL3_1 | 0.0001386435 | 0.0028919508671728217 | 4.887776236374372e-07 | 0.002892 | 1 |
| 719 | ABI3BP_1 | 0.0000085821 | 0.003065043011644369 | 1.0951385360313097e-07 | 0.003065 | 1 |
| 720 | FBRSL1_1 | 0.0000038191 | 0.0030838618137353662 | 2.4058708516257493e-06 | 0.003084 | 1 |
| 721 | RAB3C_1 | 0.0000001743 | 0.0030838618137353662 | 2.7538671921394696e-07 | 0.003084 | 1 |
| 722 | C16orf59_1 | 0.0000000275 | 0.0031574556401693433 | 1.5986180058945153e-05 | 0.003157 | 1 |
| 723 | NUP35_1 | 0.0000004963 | 0.0031574556401693433 | 1.514239152011962e-06 | 0.003157 | 1 |
| 724 | LPIN2_1 | 0.0000098827 | 0.0034466689399791843 | 2.452952119077932e-06 | 0.003447 | 1 |
| 725 | ZNF507_2 | 0.0000000111 | 0.003820596558681088 | 0.00011453249175240676 | 0.003821 | 1 |
| 726 | ADAM10_1 | 0.0000233014 | 0.0038798255226726924 | 6.64776252928381e-06 | 0.00388 | 1 |
| 727 | FBXL18_1 | 0.0000066755 | 0.0038798255226726924 | 7.005071001453964e-05 | 0.00388 | 1 |
| 728 | TMOD3_1 | 0.0000078430 | 0.0038798255226726924 | 1.2077163895524178e-08 | 0.00388 | 1 |
| 729 | HLCS_3 | 0.0000000014 | 0.003897587461379324 | 6.778958570865246e-05 | 0.003898 | 1 |
| 730 | NYNRIN_1 | 0.0000000051 | 0.0040253432504568695 | 5.327811563265487e-06 | 0.004025 | 1 |
| 731 | PDXK_1 | 0.0000012454 | 0.0041233566091711665 | 6.342148817937973e-09 | 0.004123 | 1 |
| 732 | RPS11_3 | 0.0000000443 | 0.0043239457542860625 | 1.7167121527934926e-08 | 0.004324 | 1 |
| 733 | LCE2B_1 | 0.0000000888 | 0.004326577770871151 | 8.013095879242094e-06 | 0.004327 | 1 |
| 734 | MAP2K7_3 | 0.0000000490 | 0.004508166201072404 | 3.487700085903893e-07 | 0.004508 | 1 |
| 735 | PATZ1_1 | 0.0000004164 | 0.004557941079021841 | 3.004553790169959e-08 | 0.004558 | 1 |
| 736 | SMCR7L_1 | 0.0000000162 | 0.004557941079021841 | 1.0835431093170762e-07 | 0.004558 | 1 |
| 737 | CNTNAP2_1 | 0.0000001099 | 0.004613449756294485 | 2.310283526460759e-05 | 0.004613 | 1 |
| 738 | SLC29A3_1 | 0.0000003134 | 0.004613449756294485 | 4.496266117362092e-06 | 0.004613 | 1 |
| 739 | ZBTB34_1 | 0.0000040446 | 0.004618680063226724 | 8.498577839821885e-07 | 0.004619 | 1 |
| 740 | PRKAA1_2 | 0.0000001321 | 0.004627796941857709 | 5.55517925893019e-06 | 0.004628 | 1 |
| 741 | IRF1_2 | 0.0000000003 | 0.004777571752988573 | 6.77745840075317e-08 | 0.004778 | 1 |
| 742 | GDAP1L1_5 | 0.0000000002 | 0.004808546917289599 | 1.5091907669172042e-06 | 0.004809 | 1 |
| 743 | NUP205_2 | 0.0000009871 | 0.004863314597556403 | 0.0012109741287245038 | 0.004863 | 1 |
| 744 | NUS1_1 | 0.0000000240 | 0.005366950975922179 | 3.380290864221785e-05 | 0.005367 | 1 |
| 745 | GOLT1B_3 | 0.0000022695 | 0.005599828148522198 | 3.3515801939710514e-08 | 0.0056 | 1 |
| 746 | SEC24A_2 | 0.0000000249 | 0.005701481885121388 | 7.068590877915707e-08 | 0.005701 | 1 |
| 747 | AVEN_1 | 0.0000004065 | 0.005953586357194907 | 1.3650737340980481e-05 | 0.005954 | 1 |
| 748 | BRD3_1 | 0.0000002324 | 0.0060047412034100744 | 7.118719879444557e-05 | 0.006005 | 1 |
| 749 | CBX5_1 | 0.0000008271 | 0.0060047412034100744 | 2.073650192477865e-07 | 0.006005 | 1 |
| 750 | ZNF689_1 | 0.0000000501 | 0.006037283839286274 | 8.7110715845335e-07 | 0.006037 | 1 |
| 751 | RHOG_5 | 0.0000003561 | 0.006148753448353471 | 4.9151555577284784e-05 | 0.006149 | 1 |
| 752 | SPRY1_4 | 0.0000003345 | 0.006174801125444205 | 0.0033247321236384107 | 0.006175 | 1 |
| 753 | NR1H2_2 | 0.0000000004 | 0.006201080908802092 | 7.565957176888148e-05 | 0.006201 | 1 |
| 754 | RTKN2_1 | 0.0000066891 | 0.006287821872432228 | 2.618709167085205e-06 | 0.006288 | 1 |
| 755 | CHRNA5_1 | 0.0000056104 | 0.006387086743044337 | 1.5554788280693852e-06 | 0.006387 | 1 |
| 756 | PEBP1_1 | 0.0000011028 | 0.006389356754277303 | 3.377019522860942e-08 | 0.006389 | 1 |
| 757 | CNOT6_1 | 0.0000000995 | 0.0064218708869592965 | 1.2731573046468182e-07 | 0.006422 | 1 |
| 758 | FEM1B_1 | 0.0000014595 | 0.006512658184422679 | 1.2419959836180664e-05 | 0.006513 | 1 |
| 759 | PDCD2L_1 | 0.0000198400 | 0.006732981542919481 | 7.754024385726151e-07 | 0.006733 | 1 |
| 760 | BCCIP_2 | 0.0000000036 | 0.006993057619665846 | 1.8570072163956842e-07 | 0.006993 | 1 |
| 761 | C17orf80_2 | 0.0000003489 | 0.007022396430063894 | 9.534705566156907e-06 | 0.007022 | 1 |
| 762 | TMEM229A_1 | 0.0000014642 | 0.007033451966587178 | 4.488027198291259e-06 | 0.007033 | 1 |
| 763 | AKAP1_1 | 0.0000048789 | 0.007054606953047138 | 2.2520683380861938e-08 | 0.007055 | 1 |
| 764 | EPC2_1 | 0.0000187282 | 0.007054606953047138 | 3.1361338152693263e-06 | 0.007055 | 1 |
| 765 | FKBP14_1 | 0.0000001541 | 0.007054606953047138 | 5.2000405163879345e-08 | 0.007055 | 1 |
| 766 | HMGB1_1 | 0.0000243369 | 0.007054606953047138 | 3.5582530664664353e-06 | 0.007055 | 1 |
| 767 | TMEM167B_1 | 0.0000089984 | 0.007054606953047138 | 4.903843719615824e-08 | 0.007055 | 1 |
| 768 | FURIN_1 | 0.0000013583 | 0.007154235078360664 | 0.0024498354764936592 | 0.007154 | 1 |
| 769 | FUZ_2 | 0.0000000010 | 0.007484149048900862 | 8.06345585283052e-07 | 0.007484 | 1 |
| 770 | RAX_1 | 0.0000005607 | 0.007849325275374927 | 1.5165025207033165e-06 | 0.007849 | 1 |
| 771 | HSPA5_1 | 0.0000233798 | 0.00804650712219702 | 3.3345569936160264e-07 | 0.008047 | 1 |
| 772 | SEZ6_1 | 0.0000001552 | 0.00809133905523077 | 2.1206134094154278e-05 | 0.008091 | 1 |
| 773 | CDC7_2 | 0.0000090196 | 0.00818484412008511 | 5.21476362116686e-05 | 0.008185 | 1 |
| 774 | TIMELESS_2 | 0.0000000005 | 0.008348387787825583 | 1.1506564136074267e-05 | 0.008348 | 1 |
| 775 | FAIM2_1 | 0.0000004595 | 0.008633031029057705 | 7.868329291267168e-08 | 0.008633 | 1 |
| 776 | PKIA_1 | 0.0000117746 | 0.008813705248904322 | 1.6109769990275906e-08 | 0.008814 | 1 |
| 777 | MRFAP1L1_1 | 0.0000000173 | 0.009220967328515883 | 2.2849973360661935e-07 | 0.009221 | 1 |
| 778 | SLC4A8_1 | 0.0000432316 | 0.010311927011747773 | 2.2746479512952496e-06 | 0.010312 | 1 |
| 779 | SAMM50_1 | 0.0000040988 | 0.010582443118030336 | 5.607191574381122e-07 | 0.010582 | 1 |
| 780 | FAM129A_1 | 0.0000110292 | 0.010610163045225487 | 0.00021553454881793465 | 0.01061 | 1 |
| 781 | AFMID_5 | 0.0000000000 | 0.011037504835486236 | 6.903237042102531e-06 | 0.011038 | 1 |
| 782 | STARD7_1 | 0.0000008193 | 0.011230798403991177 | 1.4750425191704724e-06 | 0.011231 | 1 |
| 783 | GPN2_2 | 0.0000000003 | 0.011286646172223367 | 0.0002020338349948365 | 0.011287 | 1 |
| 784 | PCDH9_1 | 0.0000115514 | 0.01159836162693171 | 2.5431326048421465e-05 | 0.011598 | 1 |
| 785 | DDOST_2 | 0.0000006862 | 0.011732466260948907 | 7.712332840561586e-07 | 0.011732 | 1 |
| 786 | TMEM109_3 | 0.0000000174 | 0.01179210198130457 | 1.34476580166563e-05 | 0.011792 | 1 |
| 787 | OLA1_2 | 0.0000001004 | 0.01186517030330062 | 3.4419370304963574e-06 | 0.011865 | 1 |
| 788 | RGS3_4 | 0.0000000707 | 0.012273010269850448 | 8.926332727725615e-07 | 0.012273 | 1 |
| 789 | HMGCL_1 | 0.0000057648 | 0.013135841653707197 | 6.151145606016247e-07 | 0.013136 | 1 |
| 790 | SIPA1L1_1 | 0.0000004161 | 0.013135841653707197 | 1.518269230551228e-06 | 0.013136 | 1 |
| 791 | TMEM50A_1 | 0.0000006936 | 0.013135841653707197 | 2.3186309995661696e-05 | 0.013136 | 1 |
| 792 | AP2S1_2 | 0.0005534120 | 0.013321879037458757 | 2.1009217572593065e-05 | 0.013322 | 1 |
| 793 | NARF_1 | 0.0000001706 | 0.01356093601279795 | 7.558805657306656e-07 | 0.013561 | 1 |
| 794 | S100A2_2 | 0.0000000045 | 0.013795138693676535 | 0.0009724391668072714 | 0.013795 | 1 |
| 795 | STX8_2 | 0.0010456927 | 0.013842934358702711 | 6.244242975666368e-07 | 0.013843 | 1 |
| 796 | SLC10A4_3 | 0.0000000008 | 0.0147620266284032 | 0.00012936185099713163 | 0.014762 | 1 |
| 797 | KCNAB1_1 | 0.0000177047 | 0.014856183619266723 | 1.5321385429315337e-05 | 0.014856 | 1 |
| 798 | NUFIP1_1 | 0.0000040928 | 0.015328857071669418 | 1.4820509456787599e-05 | 0.015329 | 1 |
| 799 | PUS7_1 | 0.0002258870 | 0.015382714940475899 | 0.0003699975490667046 | 0.015383 | 1 |
| 800 | TMEM33_1 | 0.0000021939 | 0.015382714940475899 | 7.8917032520098e-05 | 0.015383 | 1 |
| 801 | SUPT4H1_1 | 0.0000076733 | 0.015545833082593517 | 3.111378512146274e-05 | 0.015546 | 1 |
| 802 | B4GALT1_2 | 0.0000000036 | 0.015866838196212218 | 4.984509522594122e-08 | 0.015867 | 1 |
| 803 | TRMT1_1 | 0.0000002555 | 0.016113877031426083 | 3.5979546226837025e-05 | 0.016114 | 1 |
| 804 | ITCH_1 | 0.0000006285 | 0.016311084928625978 | 3.67059506817032e-06 | 0.016311 | 1 |
| 805 | SLC41A2_1 | 0.0000027434 | 0.016829575684385905 | 0.0002722352435422239 | 0.01683 | 1 |
| 806 | UBXN1_1 | 0.0000006760 | 0.01695446499444467 | 2.7446548902174226e-06 | 0.016954 | 1 |
| 807 | AARS2_1 | 0.0000130548 | 0.017241329872294712 | 5.7037625716450966e-05 | 0.017241 | 1 |
| 808 | ASB13_1 | 0.0000238679 | 0.017330336075027382 | 4.6209737153601604e-07 | 0.01733 | 1 |
| 809 | CSDA_1 | 0.0000009251 | 0.017443397981769932 | 0.0011464157798244399 | 0.017443 | 1 |
| 810 | DBH_1 | 0.0000079113 | 0.017443397981769932 | 1.4347684455753113e-06 | 0.017443 | 1 |
| 811 | DOK4_1 | 0.0000231034 | 0.017443397981769932 | 6.618729332114159e-06 | 0.017443 | 1 |
| 812 | FAM57B_1 | 0.0000016227 | 0.017443397981769932 | 5.886088725233178e-06 | 0.017443 | 1 |
| 813 | GRIA4_1 | 0.0000003095 | 0.017443397981769932 | 2.302309309599117e-05 | 0.017443 | 1 |
| 814 | IGFBPL1_1 | 0.0000008576 | 0.017443397981769932 | 4.783176130914827e-07 | 0.017443 | 1 |
| 815 | NFKBIZ_1 | 0.0000162804 | 0.017443397981769932 | 3.3994720134388014e-06 | 0.017443 | 1 |
| 816 | PIEZO1_1 | 0.0000001897 | 0.017443397981769932 | 1.8246285080698113e-06 | 0.017443 | 1 |
| 817 | SCN3B_1 | 0.0000011607 | 0.017443397981769932 | 1.5135394267848417e-06 | 0.017443 | 1 |
| 818 | SNAP91_1 | 0.0000071468 | 0.017443397981769932 | 2.638244061314773e-07 | 0.017443 | 1 |
| 819 | TMEM151B_1 | 0.0000049076 | 0.017443397981769932 | 2.6430931809230297e-05 | 0.017443 | 1 |
| 820 | TRAM1_1 | 0.0000027969 | 0.017443397981769932 | 1.6694679799715998e-06 | 0.017443 | 1 |
| 821 | DLGAP2_1 | 0.0000034653 | 0.017999463759106323 | 2.855153777346279e-05 | 0.017999 | 1 |
| 822 | GFRA2_2 | 0.0000000003 | 0.018137077932381954 | 0.000951735145248877 | 0.018137 | 1 |
| 823 | C12orf44_5 | 0.0000000000 | 0.018866742690223485 | 8.109600906363036e-06 | 0.018867 | 1 |
| 824 | CPD_2 | 0.0000000009 | 0.018958927953712085 | 1.967423231238389e-05 | 0.018959 | 1 |
| 825 | UNG_3 | 0.0000000006 | 0.019815116785847253 | 0.00017623188278973096 | 0.019815 | 1 |
| 826 | AGAP2_1 | 0.0000012045 | 0.020393810250137884 | 8.442387558423992e-06 | 0.020394 | 1 |
| 827 | DPY19L4_1 | 0.0000013827 | 0.020459674602965643 | 1.4759797172005466e-06 | 0.02046 | 1 |
| 828 | UST_1 | 0.0000248242 | 0.020499190298611462 | 6.68339412744453e-08 | 0.020499 | 1 |
| 829 | MAP2K7_1 | 0.0000028217 | 0.020602652898910816 | 1.2164780555581337e-05 | 0.020603 | 1 |
| 830 | DLG1_1 | 0.0000000204 | 0.02077959376727299 | 9.890664601929713e-06 | 0.02078 | 1 |
| 831 | MAPK8IP2_1 | 0.0000001600 | 0.021209400010728994 | 1.2744882761058085e-05 | 0.021209 | 1 |
| 832 | TARDBP_3 | 0.0000000007 | 0.021265954498108135 | 6.908159765653427e-06 | 0.021266 | 1 |
| 833 | CYLD_1 | 0.0000000217 | 0.0214858173069357 | 9.879543686944467e-07 | 0.021486 | 1 |
| 834 | ATL2_1 | 0.0000013494 | 0.021736958168253658 | 8.154925885406086e-06 | 0.021737 | 1 |
| 835 | SCAMP5_1 | 0.0000005258 | 0.02223324975104475 | 6.003509085007509e-09 | 0.022233 | 1 |
| 836 | ARL6IP5_1 | 0.0000000067 | 0.02225726819150785 | 1.956141813979619e-06 | 0.022257 | 1 |
| 837 | TUBD1_1 | 0.0000003011 | 0.02263296125661172 | 7.713138636684567e-05 | 0.022633 | 1 |
| 838 | OLFM3_1 | 0.0000089344 | 0.022851610694445912 | 1.8829513375080384e-05 | 0.022852 | 1 |
| 839 | ODC1_2 | 0.0000008568 | 0.022971832631374724 | 2.7504995269216484e-06 | 0.022972 | 1 |
| 840 | EXOSC8_4 | 0.0000000000 | 0.022989772746273066 | 0.0001824993302681246 | 0.02299 | 1 |
| 841 | GEMIN5_4 | 0.0000000017 | 0.023273422660848357 | 7.022368029898661e-07 | 0.023273 | 1 |
| 842 | BCLAF1_1 | 0.0000031831 | 0.023433853775319136 | 1.6892927173134977e-06 | 0.023434 | 1 |
| 843 | ADAMTSL2_3 | 0.0000000000 | 0.02345493378746214 | 2.0324998641713588e-05 | 0.023455 | 1 |
| 844 | GSDMD_1 | 0.0003698567 | 0.02361947064385562 | 1.260266686331163e-05 | 0.023619 | 1 |
| 845 | FILIP1L_1 | 0.0000442945 | 0.02380535004803143 | 4.139244014504424e-06 | 0.023805 | 1 |
| 846 | MPP5_1 | 0.0000013996 | 0.024393557193549072 | 5.899482289097565e-07 | 0.024394 | 1 |
| 847 | ZNF781_2 | 0.0000000214 | 0.024442804805679837 | 0.0002430481092405698 | 0.024443 | 1 |
| 848 | GREB1_1 | 0.0000021946 | 0.025082579510674555 | 1.026168781803766e-06 | 0.025083 | 1 |
| 849 | MICAL2_1 | 0.0000051045 | 0.025082579510674555 | 5.460450875355455e-06 | 0.025083 | 1 |
| 850 | MLKL_1 | 0.0000245887 | 0.02520256529276301 | 1.5181921351787456e-07 | 0.025203 | 1 |
| 851 | HIATL1_1 | 0.0000001697 | 0.025698116096895575 | 0.0006037318193258467 | 0.025698 | 1 |
| 852 | POFUT2_3 | 0.0000002159 | 0.025815308401600554 | 3.356964828070045e-08 | 0.025815 | 1 |
| 853 | FSD1L_3 | 0.0000000005 | 0.026091908369487455 | 0.00039856129823143474 | 0.026092 | 1 |
| 854 | SLC22A4_1 | 0.0000007929 | 0.026358068088106524 | 5.592144002080514e-06 | 0.026358 | 1 |
| 855 | ECE1_1 | 0.0000040064 | 0.027281965933944777 | 3.1606809203074195e-06 | 0.027282 | 1 |
| 856 | FAM120C_1 | 0.0000001526 | 0.027478094280566072 | 9.440653359830993e-06 | 0.027478 | 1 |
| 857 | WDR18_1 | 0.0000002870 | 0.02811272649847224 | 2.0929795909688486e-06 | 0.028113 | 1 |
| 858 | SPAST_2 | 0.0000001330 | 0.028348027782966405 | 3.9367533477728655e-06 | 0.028348 | 1 |
| 859 | RIN2_1 | 0.0000003608 | 0.028653860870043152 | 1.4769971196556159e-05 | 0.028654 | 1 |
| 860 | RUNX2_2 | 0.0000000005 | 0.028974052520507214 | 2.14065240634782e-06 | 0.028974 | 1 |
| 861 | NOP14_2 | 0.0000005983 | 0.02901206601493043 | 9.523685001792411e-07 | 0.029012 | 1 |
| 862 | MAN2B2_1 | 0.0000027972 | 0.029245906890336886 | 1.4933063823416558e-06 | 0.029246 | 1 |
| 863 | PAIP1_1 | 0.0000007230 | 0.029320244216402155 | 2.7441426734443414e-07 | 0.02932 | 1 |
| 864 | DHX32_2 | 0.0000533846 | 0.029344624633688917 | 6.043863871216864e-07 | 0.029345 | 1 |
| 865 | PLK2_2 | 0.0002388183 | 0.029905384844343543 | 2.063197005965159e-06 | 0.029905 | 1 |
| 866 | PRCC_1 | 0.0000001861 | 0.029926219059845965 | 1.1405008131610388e-06 | 0.029926 | 1 |
| 867 | XAF1_1 | 0.0000358261 | 0.030280074734233196 | 7.286165792821834e-08 | 0.03028 | 1 |
| 868 | METAP2_1 | 0.0000087458 | 0.030556265901493518 | 3.240583308159839e-07 | 0.030556 | 1 |
| 869 | CLK2_1 | 0.0000011413 | 0.030888289103249412 | 7.675595673276064e-06 | 0.030888 | 1 |
| 870 | DPP6_1 | 0.0000000203 | 0.03100397440582499 | 5.0469470139700276e-05 | 0.031004 | 1 |
| 871 | ACSL4_3 | 0.0000020398 | 0.03149060869705135 | 1.5068270568910291e-05 | 0.031491 | 1 |
| 872 | ANKIB1_1 | 0.0000005533 | 0.032332967518234994 | 5.693423471624403e-07 | 0.032333 | 1 |
| 873 | MRPL44_1 | 0.0000004285 | 0.03320176795710607 | 7.58534516483232e-07 | 0.033202 | 1 |
| 874 | ECSIT_1 | 0.0000000613 | 0.033538144332397844 | 9.327207467647707e-06 | 0.033538 | 1 |
| 875 | UTRN_1 | 0.0000011107 | 0.033538144332397844 | 2.5789968645189164e-06 | 0.033538 | 1 |
| 876 | KLHL3_1 | 0.0000383917 | 0.0344114911006157 | 3.244555435191599e-05 | 0.034411 | 1 |
| 877 | PPP3CC_1 | 0.0004859138 | 0.03515778354911297 | 6.188875946486586e-05 | 0.035158 | 1 |
| 878 | ZNF146_2 | 0.0000000002 | 0.03744996129971014 | 0.00011861207253864054 | 0.03745 | 1 |
| 879 | ZNF561_1 | 0.0000000634 | 0.03880023351870834 | 2.016596236878262e-06 | 0.0388 | 1 |
| 880 | GABRB3_2 | 0.0000004163 | 0.03908988372883462 | 1.4145265356070185e-06 | 0.03909 | 1 |
| 881 | FUCA2_2 | 0.0000010455 | 0.040900774628950205 | 4.509971577380666e-08 | 0.040901 | 1 |
| 882 | ZNF704_1 | 0.0000003968 | 0.04141199786610875 | 3.2915671737970186e-07 | 0.041412 | 1 |
| 883 | RSRC2_1 | 0.0000006681 | 0.04263760212726399 | 8.124905418115654e-06 | 0.042638 | 1 |
| 884 | ZNF786_4 | 0.0000003689 | 0.04302185346161887 | 0.00017227082461867952 | 0.043022 | 1 |
| 885 | FAM208A_4 | 0.0000001168 | 0.04317698799820883 | 6.901563255423604e-06 | 0.043177 | 1 |
| 886 | KLC1_2 | 0.0000000029 | 0.04326421162343569 | 9.50085593569108e-05 | 0.043264 | 1 |
| 887 | C4orf46_1 | 0.0000014299 | 0.04398087969459366 | 0.0001711178965703045 | 0.043981 | 1 |
| 888 | PFDN2_1 | 0.0000002586 | 0.044291333594155616 | 1.8451067079767974e-09 | 0.044291 | 1 |
| 889 | TMEM88_1 | 0.0000001338 | 0.04436920294909983 | 3.529178026304605e-07 | 0.044369 | 1 |
| 890 | CAMKMT_1 | 0.0000058447 | 0.045390286722626634 | 3.532704674941749e-05 | 0.04539 | 1 |
| 891 | RAB3A_5 | 0.0000000000 | 0.04677739444487693 | 1.0728714113996382e-05 | 0.046777 | 1 |
| 892 | PPP1R3C_1 | 0.0000160727 | 0.046988563883468094 | 6.183139691881509e-07 | 0.046989 | 1 |
| 893 | RNPS1_1 | 0.0000017303 | 0.04934110523099186 | 2.7030460144558537e-06 | 0.049341 | 1 |
| 894 | SESN1_1 | 0.0000827949 | 0.049980571686550485 | 0.00013996827329482083 | 0.049981 | 1 |
[표 8]에는 두경부암(head&neck) 약물에 연관된 FRH 들과, 이와 연관된 두경부암 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 9] 에는 [표 8]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(Pvlaue)값을 의미하는 것으로, [표 8]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 8]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 두경부암 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 31에는 표 8에 기재된 바이오마커들 중 주요 바이오마커들의 두경부암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 32에는 주요 바이오마커들에 의해 발현된 유전자들과 두경부암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Drug | DrugType | Var(마커) |
| 1 | RAI14_2 | 60_BI-2536 / 87_GW843682X / 150_Bicalutamide / 155_AP-24534 / 269_NSC-207895 / 295_NVP-BHG712 / 341_EX-527 / 1016_Temsirolimus / 1032_Afatinib / 1036_PLX4720 / 1057_NVP-BEZ235 / 1061_SB590885 / 1175_AG-014699 / 1219_PFI-1 / 1241_CHIR-99021 / 1242_(5Z)-7-Oxozeaenol / 1371_PLX4720 (rescreen) / 1372_Trametinib / 1373_Dabrafenib / 1377_Afatinib (rescreen) | mitosis / mitosis / other / abl / p53 / rtk / other / tor / egfr / erk_mapk / pi3k / erk_mapk / g_integrity / chromatin / wnt / other / erk_mapk / erk_mapk / erk_mapk / egfr | 14_21082261_T_G / 7_140753336_A_T |
| 2 | ELK3_1 | 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 / 1526_Refametinib_3 / 1371_PLX-4720_3 / 1372_Trametinib_1 | erk_mapk / other / erk_mapk / erk_mapk / erk_mapk | 14_21082261_T_G |
| 3 | RAI14_2 | 1373_Dabrafenib_1 / 1371_PLX-4720_3 / 1242_(5Z)-7-Oxozeaenol_3 | erk_mapk / erk_mapk / other | 14_21082261_T_G / 5_94871301_T_G |
| 4 | NOTCH2_1 | 1371_PLX-4720_3 / 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 | erk_mapk / erk_mapk / other | 20_63940084_T_G |
| 5 | CATSPER1_1 | 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 | erk_mapk / other | 7_140753336_A_T |
| 6 | TNIP1_2 | 1373_Dabrafenib_1 / 1371_PLX-4720_3 | erk_mapk / erk_mapk | 5_154823483_T_G / 15_32616231_T_G |
| 7 | PTX3_2 | 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 | erk_mapk / other | 7_140753336_A_T / 14_21082261_T_G |
| 8 | ZHX3_1 | 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 | erk_mapk / other | 7_72926354_C_T |
| 9 | SH2D3A_1 | 1010_Gefitinib_1 / 1377_Afatinib_1 | egfr / egfr | 6_129475475_C_T |
| 10 | SLC39A13_5 | 1373_Dabrafenib_1 / 1242_(5Z)-7-Oxozeaenol_3 | erk_mapk / other | 14_21082261_T_G / 7_140753336_A_T / 11_85724752_T_C / 3_48790461_T_G / 17_35259011_T_G |
| 11 | GJB6_1 | 1032_Afatinib_1 / 1114_Cetuximab_1 | egfr / egfr | 1_44978366_G_A |
| 12 | PLAU_2 | 1494_SN-38_3 / 1259_Talazoparib_3 | DNArep / g_integrity | 16_2519752_T_C / 9_114307582_T_G |
| 13 | ATG7_1 | 1373_Dabrafenib_1 | erk_mapk | 7_140753336_A_T |
| 14 | CACNG4_3 | 1373_Dabrafenib_1 | erk_mapk | 7_140753336_A_T / 16_11174168_A_G / 6_5771301_A_C |
| 15 | GJB2_1 | 1032_Afatinib_1 | egfr | 1_44978366_G_A |
| 16 | DOCK4_2 | 1373_Dabrafenib_1 | erk_mapk | 9_76227464_A_G / 7_140753336_A_T |
| 17 | AP1M2_3 | 1377_Afatinib_1 | egfr | 1_2521130_T_C / 12_50718803_T_C / 1_2491175_G_A |
| 18 | RNF216_1 | 1021_Axitinib_2 | rtk | 10_45443298_C_T |
| 19 | IRX2_3 | 1373_Dabrafenib_1 | erk_mapk | 1_2562891_G_A / 12_14460981_T_A / 7_140753336_A_T |
| 20 | CXADR_4 | 1242_(5Z)-7-Oxozeaenol_3 | other | 14_21082261_T_G / 3_47333236_T_C / 18_8387094_T_G / 17_63831142_T_G |
| 21 | NEBL_1 | 1242_(5Z)-7-Oxozeaenol_3 | other | 7_72926354_C_T |
| 22 | FXYD3_1 | 1032_Afatinib_1 | egfr | 22_50625559_G_C |
| 23 | SERPINB5_1 | 1032_Afatinib_1 | egfr | 22_50625559_G_C |
| 24 | GJB3_1 | 1010_Gefitinib_1 | egfr | 6_129475475_C_T |
| 25 | GJB5_1 | 1010_Gefitinib_1 | egfr | 6_129475475_C_T |
| 26 | WNT10A_1 | 1010_Gefitinib_1 | egfr | 6_129475475_C_T |
| 27 | ACLY_1 | 255_CP724714_2 | egfr | 15_26976868_T_A |
| 28 | KRT6A_1 | 1114_Cetuximab_1 | egfr | 22_50576781_G_C |
| 29 | PRADC1_1 | 1037_BX796_2 | other | 2_53899904_C_T |
| 30 | TIMP1_1 | 1373_Dabrafenib_1 | erk_mapk | 19_9985806_C_T |
| 31 | GYLTL1B_2 | 1032_Afatinib_1 | egfr | 7_5938011_C_CCA / 7_5945090_C_T |
| 32 | PTCHD4_4 | 1373_Dabrafenib_1 | erk_mapk | 11_4102115_C_G / 11_4132537_A_G / 11_4112087_C_A / 11_4138236_G_A |
| No. | FRH | Var_Exp(pval) | Var_Drug(pval) | Exp_Drug(pval) | Ave_VarDrug(pval) | Rank |
| 1 | RAI14_2 | 1.50E-07 | 0.002427316 / 0.007905787 / 0.009050202 / 0.008885028 / 0.006973327 / 0.008993803 / 0.006448846 / 0.003370265 / 0.005536324 / 7.23E-05 / 0.008957232 / 0.006831953 / 0.007786364 / 0.009533459 / 0.002310426 / 0.006104376 / 2.92E-05 / 0.003064818 / 1.61E-05 / 0.009911234 | 0.07094644 / 0.187614118 / 0.000121399 / 0.070569119 / 0.006038396 / 0.070019258 / 0.001656899 / 0.051790523 / 0.024868194 / 0.001587975 / 0.005704322 / 0.20488317 / 0.010104768 / 0.019630304 / 0.019900005 / 1.24E-05 / 2.38E-05 / 0.00050772 / 1.09E-06 / 0.018141082 | 0.00571 | 20 |
| 2 | ELK3_1 | 0.0000051495 | 8.520565972551354e-05 / 0.015525162300909256 / 0.022555240944218617 / 9.519623606517973e-05 / 0.007329786178994242 | 1.490382050697451e-07 / 5.969489582574335e-06 / 6.8362891216619816e-06 / 9.005519185972905e-06 / 6.49148403527597e-05 | 0.009118 | 5 |
| 3 | RAI14_2 | 0.0000000017 | 0.0008802720058814783 / 4.733202001463438e-05 / 0.011225192753415226 | 1.0853407136502757e-06 / 2.4863984008159652e-05 / 1.2422979331681213e-05 | 0.004051 | 3 |
| 4 | NOTCH2_1 | 0.0003642485 | 0.0022063266509928054 / 0.0011467762666252258 / 0.03692401606377258 | 8.758068948702604e-05 / 3.0310746014375745e-05 / 1.8526402456030966e-05 | 0.013426 | 3 |
| 5 | CATSPER1_1 | 0.0000542935 | 4.909220079323596e-06 / 0.00011457004964965411 | 0.0004960672627266704 / 4.1877269236589585e-05 | 5.97E-05 | 2 |
| 6 | TNIP1_2 | 0.0000000375 | 0.001606622034643822 / 2.7862939972941576e-05 | 0.0015404489011240819 / 5.038713072540372e-05 | 0.000817 | 2 |
| 7 | PTX3_2 | 0.0000000676 | 1.211019112884484e-05 / 0.004691088270564708 | 5.3217448419493556e-05 / 4.863050561584803e-06 | 0.002352 | 2 |
| 8 | ZHX3_1 | 0.0000014893 | 0.006509687182728191 / 0.008743794449442545 | 0.0040675934215217225 / 0.00019098934171098681 | 0.007627 | 2 |
| 9 | SH2D3A_1 | 0.0000000320 | 0.00986450275259379 / 0.01796408266328998 | 7.462758949668892e-07 / 1.1020918776918554e-08 | 0.013914 | 2 |
| 10 | SLC39A13_5 | 0.0000000002 | 0.00012981264623764855 / 0.030218992308456684 | 0.0004149038678616304 / 0.00016053338154515 | 0.015174 | 2 |
| 11 | GJB6_1 | 0.0000254994 | 0.0011057846043825926 / 0.04337830840329379 | 4.1575916269860694e-08 / 1.3980763861975182e-05 | 0.022242 | 2 |
| 12 | PLAU_2 | 0.0000006538 | 0.03531794281050409 / 0.02526666710345045 | 4.043892919121399e-05 / 3.9199708585004496e-05 | 0.030292 | 2 |
| 13 | ATG7_1 | 0.0000274102 | 4.909220079323596e-06 | 0.009126969696896518 | 4.91E-06 | 1 |
| 14 | CACNG4_3 | 0.0000000067 | 0.00039102555284760144 | 0.031972846680865336 | 0.000391 | 1 |
| 15 | GJB2_1 | 0.0000006418 | 0.0011057846043825926 | 2.887574461802551e-08 | 0.001106 | 1 |
| 16 | DOCK4_2 | 0.0000000000 | 0.0011991500921208242 | 0.0022356151864022953 | 0.001199 | 1 |
| 17 | AP1M2_3 | 0.0000000001 | 0.0033347052264227745 | 1.674996902910247e-06 | 0.003335 | 1 |
| 18 | RNF216_1 | 0.0007334440 | 0.003910529109685535 | 0.013334064866138773 | 0.003911 | 1 |
| 19 | IRX2_3 | 0.0000000213 | 0.0039795105649417465 | 0.008040031167638424 | 0.00398 | 1 |
| 20 | CXADR_4 | 0.0000000000 | 0.004008851856771511 | 0.00015472825463944093 | 0.004009 | 1 |
| 21 | NEBL_1 | 0.0000067597 | 0.008743794449442545 | 1.0527193471616602e-05 | 0.008744 | 1 |
| 22 | FXYD3_1 | 0.0008131704 | 0.009811440592786477 | 6.611291968968659e-11 | 0.009811 | 1 |
| 23 | SERPINB5_1 | 0.0000043595 | 0.009811440592786477 | 6.545929986856144e-07 | 0.009811 | 1 |
| 24 | GJB3_1 | 0.0000000848 | 0.00986450275259379 | 1.9745785897164974e-07 | 0.009865 | 1 |
| 25 | GJB5_1 | 0.0000001095 | 0.00986450275259379 | 3.7414591927831155e-08 | 0.009865 | 1 |
| 26 | WNT10A_1 | 0.0000000002 | 0.00986450275259379 | 1.0155161311414058e-06 | 0.009865 | 1 |
| 27 | ACLY_1 | 0.0000197234 | 0.01038305959856784 | 0.0002073002808779262 | 0.010383 | 1 |
| 28 | KRT6A_1 | 0.0000039996 | 0.011822174156922029 | 6.092827819585888e-07 | 0.011822 | 1 |
| 29 | PRADC1_1 | 0.0000003553 | 0.01619549339490529 | 4.216127554465152e-06 | 0.016195 | 1 |
| 30 | TIMP1_1 | 0.0000442505 | 0.019824604635656325 | 0.00012088359791880537 | 0.019825 | 1 |
| 31 | GYLTL1B_2 | 0.0000000917 | 0.027132275398936593 | 1.8977666799314624e-07 | 0.027132 | 1 |
| 32 | PTCHD4_4 | 0.0003324429 | 0.04021455535799824 | 0.0022163934450957286 | 0.040215 | 1 |
[표 10]에는 폐암(lung) 약물에 연관된 FRH 들과, 이와 연관된 폐암 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 11] 에는 [표 10]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(Pvlaue)값을 의미하는 것으로, [표 10]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 10]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 폐암 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 33에는 표 10에 기재된 바이오마커들 중 주요 바이오마커들의 폐암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 34에는 주요 바이오마커들에 의해 발현된 유전자들과 폐암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Drug | DrugType | Var(마커) |
| 1 | POLR3K_5 | 290_KIN001-260 / 287_KIN001-244 / 308_XL-880 / 261_TL-1-85 / 329_QL-XI-92 / 269_NSC-207895 / 332_XMD15-27 / 1268_XAV 939 / 1495_Olaparib / 260_NG-25 / 265_Tubastatin A / 1011_ABT-263 / 310_YM201636 / 249_XL-184 / 266_Zibotentan / 273_CUDC-101 / 1021_Axitinib / 277_ABT-869 / 1008_Methotrexate / 272_AR-42 / 271_VNLG/124 / 288_KIN001-055 / 312_AV-951 / 1375_Temozolomide / 346_THZ-2-102-1 / 262_VX-11e / 150_Bicalutamide / 206_Ruxolitinib / 328_SNX-2112 / 91_KIN001-135 / 1017_Olaparib / 300_CX-5461 / 152_CP466722 / 276_CAY10603 / 252_WZ3105 / 257_NPK76-II-72-1 / 1158_XMD11-85h / 226_GSK1070916 / 254_AC220 | other / pi3k / rtk / other / rtk / p53 / other / wnt / g_integrity / other / chromatin / apop / other / rtk / other / chromatin / rtk / rtk / DNArep / chromatin / chromatin / other / rtk / DNArep / cell_cyc / erk_mapk / other / other / other / other / g_integrity / other / g_integrity / chromatin / other / mitosis / other / mitosis / rtk | 2_217847583_C_T / 2_71424561_G_GT / 2_217847883_G_A / 2_217848003_A_G / 17_81206909_A_C |
| 2 | FAM114A1_1 | 326_GSK690693_3 / 1011_Navitoclax_2 / 252_WZ3105_3 / 1248_Daporinad_3 / 299_OSI-027_2 / 269_NSC-207895_3 / 226_GSK1070916_2 / 330_XMD13-2_3 / 302_PI-103_3 / 257_NPK76-II-72-1_3 / 331_QL-X-138_3 / 312_Tivozanib_2 | pi3k / apop / other / metabol / tor / p53 / mitosis / other / pi3k / mitosis / other / rtk | 2_217847583_C_T |
| 3 | AVPI1_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 / 1007_Docetaxel_1 / 1014_Refametinib_2 / 1060_PD0325901_2 / 1114_Cetuximab_1 / 1015_CI-1040_2 / 1378_Bleomycin(50uM)_1 / 1268_XAV939_3 / 1031_Elesclomol_2 | erk_mapk / erk_mapk / other / erk_mapk / cytoskeleton / erk_mapk / erk_mapk / egfr / erk_mapk / DNArep / wnt / other | 3_157413999_A_C |
| 4 | S100A11_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1014_Refametinib_2 / 1377_Afatinib_1 / 172_Embelin_2 / 1060_PD0325901_2 / 207_AS601245_3 / 1114_Cetuximab_1 / 1378_Bleomycin(50uM)_1 / 1032_Afatinib_1 | erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / egfr / apop / erk_mapk / jnk_p38 / egfr / DNArep / egfr | 11_124145287_C_T |
| 5 | TMEM92_2 | 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 51_Dasatinib_1 / 159_HG6-64-1_3 / 201_Epothilone B_2 / 1007_Docetaxel_1 / 207_AS601245_3 / 194_Luminespib_2 / 1054_Palbociclib_2 | other / erk_mapk / erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk / cytoskeleton / cytoskeleton / jnk_p38 / other / cell_cyc | 8_1565648_A_G / 9_61104415_C_T |
| 6 | ATP6V0B_1 | 1378_Bleomycin(50uM)_1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 51_Dasatinib_1 / 1007_Docetaxel_1 / 1015_CI-1040_2 / 1498_Selumetinib_2 / 1016_Temsirolimus_1 / 172_Embelin_2 / 59_WZ-1-84_3 / 282_Pelitinib_2 / 1377_Afatinib_1 | DNArep / erk_mapk / erk_mapk / abl / cytoskeleton / erk_mapk / erk_mapk / tor / apop / other / egfr / egfr | 17_78529723_C_G |
| 7 | GBP1_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1007_Docetaxel_1 / 1015_CI-1040_2 / 182_Obatoclax Mesylate_2 / 167_OSU-03012_3 / 1062_Selumetinib_2 / 51_Dasatinib_1 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton / erk_mapk / apop / pi3k / erk_mapk / abl | 3_55480738_A_T |
| 8 | ERLEC1_1 | 326_GSK690693_3 / 1011_Navitoclax_2 / 252_WZ3105_3 / 299_OSI-027_2 / 330_XMD13-2_3 / 312_Tivozanib_2 / 302_PI-103_3 / 222_BX-912_3 / 329_QL-XI-92_3 | pi3k / apop / other / tor / other / rtk / pi3k / pi3k / rtk | 10_52768593_C_G |
| 9 | SSH3_1 | 1372_Trametinib_1 / 1377_Afatinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1114_Cetuximab_1 / 1010_Gefitinib_1 / 1015_CI-1040_2 / 1378_Bleomycin(50uM)_1 | erk_mapk / egfr / erk_mapk / erk_mapk / egfr / egfr / egfr / erk_mapk / DNArep | 3_7680310_G_A |
| 10 | TRIP10_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1378_Bleomycin(50uM)_1 / 1054_Palbociclib_2 / 1007_Docetaxel_1 | erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / erk_mapk / DNArep / cell_cyc / cytoskeleton | 14_20381224_T_G |
| 11 | MAN1B1_5 | 1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 / 1015_CI-1040_2 / 1114_Cetuximab_1 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1026_Tanespimycin_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / other | 19_57490144_T_A / 19_57473550_A_G / 19_57507480_A_G / 19_57455681_G_T / 19_57455765_G_A |
| 12 | CD151_2 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 172_Embelin_2 / 1060_PD0325901_2 / 1026_Tanespimycin_2 / 182_Obatoclax Mesylate_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / apop / erk_mapk / other / apop | 3_3845235_C_T / 3_3845163_G_C |
| 13 | PDLIM7_1 | 1007_Docetaxel_1 / 159_HG6-64-1_3 / 1026_Tanespimycin_2 / 1015_CI-1040_2 / 1372_Trametinib_1 / 1054_Palbociclib_2 / 1498_Selumetinib_2 / 1062_Selumetinib_2 | cytoskeleton / erk_mapk / other / erk_mapk / erk_mapk / cell_cyc / erk_mapk / erk_mapk | 16_84872374_G_C |
| 14 | GLIPR1_1 | 1372_Trametinib_1 / 1007_Docetaxel_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1054_Palbociclib_2 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1026_Tanespimycin_2 | erk_mapk / cytoskeleton / erk_mapk / erk_mapk / cell_cyc / erk_mapk / erk_mapk / other | 16_55398_G_T |
| 15 | GPR87_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1032_Afatinib_1 / 1378_Bleomycin(50uM)_1 | erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / egfr / DNArep | 19_15807367_G_T |
| 16 | SNAP25_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1015_CI-1040_2 / 1014_Refametinib_2 / 1032_Afatinib_1 / 1007_Docetaxel_1 | erk_mapk / erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk / egfr / cytoskeleton | 2_71424561_G_GT |
| 17 | FGFBP1_2 | 1372_Trametinib_1 / 1377_Afatinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1010_Gefitinib_1 / 1015_CI-1040_2 | erk_mapk / egfr / erk_mapk / erk_mapk / egfr / egfr / erk_mapk | 2_65069680_A_C / 17_81206909_A_C |
| 18 | CHN1_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1015_CI-1040_2 / 1010_Gefitinib_1 | erk_mapk / erk_mapk / egfr / erk_mapk / egfr / erk_mapk / egfr | 17_81206909_A_C |
| 19 | ACSF2_4 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1114_Cetuximab_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1377_Afatinib_1 / 1026_Tanespimycin_2 | erk_mapk / erk_mapk / egfr / erk_mapk / egfr / egfr / other | 2_71424561_G_GT / 2_71433365_T_TC / 2_71393433_A_G / 2_71428456_T_A |
| 20 | SNAPC3_1 | 1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 / 1060_PD0325901_2 / 1007_Docetaxel_1 | erk_mapk / other / erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton | 15_71256598_T_C |
| 21 | ZFP82_1 | 1377_Afatinib_1 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1114_Cetuximab_1 / 1526_Refametinib_3 / 1032_Afatinib_1 / 1010_Gefitinib_1 | egfr / erk_mapk / erk_mapk / egfr / erk_mapk / egfr / egfr | 3_33120406_C_T |
| 22 | OPHN1_1 | 1016_Temsirolimus_1 / 1007_Docetaxel_1 / 1372_Trametinib_1 / 1054_Palbociclib_2 / 1526_Refametinib_3 / 1019_Bosutinib_1 / 1026_Tanespimycin_2 | tor / cytoskeleton / erk_mapk / cell_cyc / erk_mapk / abl / other | 12_54002598_T_G |
| 23 | TNS3_1 | 1014_Refametinib_2 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1060_PD0325901_2 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / other / erk_mapk | 7_47967711_A_T |
| 24 | P2RY6_5 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 / 1498_Selumetinib_2 / 1032_Afatinib_1 / 1014_Refametinib_2 | erk_mapk / erk_mapk / egfr / erk_mapk / egfr / erk_mapk | 2_71424561_G_GT / 2_71399439_CTA_C / 2_71398637_G_A / 2_71393433_A_G / 2_71428456_T_A |
| 25 | SCO2_3 | 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1007_Docetaxel_1 / 1526_Refametinib_3 / 1170_CCT-018159_3 / 1014_Refametinib_2 | other / erk_mapk / cytoskeleton / erk_mapk / other / erk_mapk | X_14581235_C_G / X_14581237_T_G / X_55487442_C_G |
| 26 | KHSRP_1 | 302_PI-103_3 / 299_OSI-027_2 / 252_WZ3105_3 / 301_PHA-793887_3 / 330_XMD13-2_3 / 1248_Daporinad_3 | pi3k / tor / other / cell_cyc / other / metabol | 4_119158232_G_A |
| 27 | TTC3_1 | 1007_Docetaxel_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 / 1114_Cetuximab_1 | cytoskeleton / other / erk_mapk / erk_mapk / erk_mapk / egfr | 12_66128870_G_A |
| 28 | STEAP1_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1026_Tanespimycin_2 / 1014_Refametinib_2 / 1060_PD0325901_2 | erk_mapk / erk_mapk / erk_mapk / other / erk_mapk / erk_mapk | 17_50677651_A_G |
| 29 | RNF207_2 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1015_CI-1040_2 / 1026_Tanespimycin_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk / other | 9_134036501_T_G / 16_68564104_A_G |
| 30 | C16orf59_2 | 257_NPK76-II-72-1_3 / 1248_Daporinad_3 / 269_NSC-207895_3 / 265_Tubastatin A_3 / 275_I-BET-762_3 | mitosis / metabol / p53 / chromatin / chromatin | 2_217847583_C_T / 2_217847883_G_A |
| 31 | ICAM1_1 | 1372_Trametinib_1 / 1498_Selumetinib_2 / 1377_Afatinib_1 / 1526_Refametinib_3 / 159_HG6-64-1_3 | erk_mapk / erk_mapk / egfr / erk_mapk / erk_mapk | 8_12358868_A_G |
| 32 | POLE_1 | 1011_Navitoclax_2 / 269_NSC-207895_3 / 193_GW-2580_3 / 1012_Vorinostat_1 / 1248_Daporinad_3 | apop / p53 / rtk / chromatin / metabol | 2_217847583_C_T |
| 33 | MYT1_3 | 1011_Navitoclax_2 / 1248_Daporinad_3 / 269_NSC-207895_3 / 211_TL-2-105_3 / 326_GSK690693_3 | apop / metabol / p53 / erk_mapk / pi3k | 2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A |
| 34 | MMRN2_1 | 1377_Afatinib_1 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1114_Cetuximab_1 / 1498_Selumetinib_2 | egfr / erk_mapk / erk_mapk / egfr / erk_mapk | 19_15807367_G_T |
| 35 | ZNF420_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1007_Docetaxel_1 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / cytoskeleton | 6_53654807_C_T |
| 36 | ELOVL1_2 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1498_Selumetinib_2 / 1014_Refametinib_2 | erk_mapk / erk_mapk / other / erk_mapk / erk_mapk | 1_203683316_A_G / 1_203698281_T_C |
| 37 | CHGB_1 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 51_Dasatinib_1 / 1014_Refametinib_2 | erk_mapk / erk_mapk / erk_mapk / abl / erk_mapk | 15_67236036_T_G |
| 38 | MLKL_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1026_Tanespimycin_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / other | 17_80137479_A_T |
| 39 | FEZ2_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1007_Docetaxel_1 / 1239_YK-4-279_3 / 1060_PD0325901_2 | erk_mapk / erk_mapk / cytoskeleton / other / erk_mapk | X_108735142_T_G |
| 40 | ADNP2_1 | 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 | other / erk_mapk / erk_mapk / erk_mapk | 9_41294004_C_A |
| 41 | CES2_1 | 1498_Selumetinib_2 / 1526_Refametinib_3 / 1372_Trametinib_1 / 1010_Gefitinib_1 | erk_mapk / erk_mapk / erk_mapk / egfr | 8_17085328_C_T |
| 42 | DDR1_2 | 1377_Afatinib_1 / 1010_Gefitinib_1 / 1032_Afatinib_1 / 1372_Trametinib_1 | egfr / egfr / egfr / erk_mapk | 2_174801578_A_G / 4_89936328_G_A |
| 43 | PTGR1_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1026_Tanespimycin_2 / 1014_Refametinib_2 | erk_mapk / erk_mapk / other / erk_mapk | 19_45698914_C_T |
| 44 | LIN7A_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 13_45541596_C_A |
| 45 | SYNCRIP_1 | 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 301_PHA-793887_3 / 222_BX-912_3 | mitosis / other / cell_cyc / pi3k | 4_87340676_A_C |
| 46 | EREG_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 17_50677651_A_G |
| 47 | C12orf57_1 | 1007_Docetaxel_1 / 1114_Cetuximab_1 / 1372_Trametinib_1 / 204_Tipifarnib_2 | cytoskeleton / egfr / erk_mapk / other | 1_103082763_C_G |
| 48 | PARP9_1 | 1377_Afatinib_1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 | egfr / erk_mapk / erk_mapk / erk_mapk | 4_185267219_TA_T |
| 49 | SLITRK3_1 | 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1526_Refametinib_3 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 8_378251_A_G |
| 50 | BIRC7_2 | 1372_Trametinib_1 / 1066_AZD6482_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 | erk_mapk / pi3k / erk_mapk / erk_mapk | 17_78510525_G_A / 17_78507511_T_C |
| 51 | ID4_1 | 173_FH535_3 / 1526_Refametinib_3 / 182_Obatoclax Mesylate_2 / 1372_Trametinib_1 | other / erk_mapk / apop / erk_mapk | 4_9334816_T_C |
| 52 | NUCB2_1 | 1142_HG-5-113-01_2 / 1054_Palbociclib_2 / 182_Obatoclax Mesylate_2 / 1239_YK-4-279_3 | abl / cell_cyc / apop / other | 8_26370124_A_G |
| 53 | PDLIM1_2 | 1377_Afatinib_1 / 1372_Trametinib_1 / 1526_Refametinib_3 / 1010_Gefitinib_1 | egfr / erk_mapk / erk_mapk / egfr | 11_124186080_G_A / 11_124224942_C_A |
| 54 | RNF219_3 | 1011_Navitoclax_2 / 269_NSC-207895_3 / 230_GSK429286A_3 / 226_GSK1070916_2 | apop / p53 / cytoskeleton / mitosis | 10_31363289_T_C / 2_68528704_T_C / 16_60358945_T_C |
| 55 | CTRB2_1 | 1378_Bleomycin(50uM)_1 / 1242_(5Z)-7-Oxozeaenol_3 / 1372_Trametinib_1 / 1526_Refametinib_3 | DNArep / other / erk_mapk / erk_mapk | 4_37433902_C_T |
| 56 | RAB31_2 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | X_81277112_A_C / 6_32027037_A_C |
| 57 | INADL_2 | 1010_Gefitinib_1 / 1377_Afatinib_1 / 1032_Afatinib_1 | egfr / egfr / egfr | 3_58285236_T_C / 2_241246976_C_T |
| 58 | DPYSL4_5 | 1011_Navitoclax_2 / 269_NSC-207895_3 / 275_I-BET-762_3 | apop / p53 / chromatin | 2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A / 2_217847379_A_G / 2_217842134_T_C |
| 59 | TMEM71_1 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk | 8_12358868_A_G |
| 60 | TPD52L2_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk | 9_134036501_T_G |
| 61 | PDIA3_2 | 269_NSC-207895_3 / 1011_Navitoclax_2 / 193_GW-2580_3 | p53 / apop / rtk | 10_52768593_C_G / 15_19964850_A_G |
| 62 | KCNK6_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk | 17_81206909_A_C |
| 63 | CASP8AP2_2 | 1011_Navitoclax_2 / 326_GSK690693_3 / 269_NSC-207895_3 | apop / pi3k / p53 | 6_109431362_C_A / 10_24584658_G_C |
| 64 | LIG1_2 | 1011_Navitoclax_2 / 269_NSC-207895_3 / 193_GW-2580_3 | apop / p53 / rtk | 2_217847583_C_T / 2_217848003_A_G |
| 65 | ARVCF_1 | 1526_Refametinib_3 / 1372_Trametinib_1 / 172_Embelin_2 | erk_mapk / erk_mapk / apop | 15_71256598_T_C |
| 66 | PPP1R13L_1 | 1011_Navitoclax_2 / 211_TL-2-105_3 / 254_Quizartinib_2 | apop / erk_mapk / rtk | 7_33099535_G_A |
| 67 | ELL2_1 | 1011_Navitoclax_2 / 1248_Daporinad_3 / 269_NSC-207895_3 | apop / metabol / p53 | 6_32183680_C_G |
| 68 | TMEM74_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1378_Bleomycin(50uM)_1 | erk_mapk / erk_mapk / DNArep | 15_67236036_T_G |
| 69 | SH3KBP1_1 | 207_AS601245_3 / 172_Embelin_2 / 204_Tipifarnib_2 | jnk_p38 / apop / other | 8_12358868_A_G |
| 70 | AGXT2L2_4 | 1011_Navitoclax_2 / 193_GW-2580_3 / 269_NSC-207895_3 | apop / rtk / p53 | 2_217847583_C_T / 2_217848003_A_G / 2_217847883_G_A / 2_217848559_G_A |
| 71 | FLNA_1 | 159_HG6-64-1_3 / 153_Midostaurin_2 / 51_Dasatinib_1 | erk_mapk / rtk / abl | 3_118902653_C_T |
| 72 | EVPL_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1377_Afatinib_1 | erk_mapk / erk_mapk / egfr | 15_84798628_G_A |
| 73 | ITPRIPL1_1 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1014_Refametinib_2 | erk_mapk / erk_mapk / erk_mapk | 2_24209270_T_C |
| 74 | MFSD5_3 | 1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 | erk_mapk / other / erk_mapk | 10_96386941_T_G / 10_93374837_C_T / 12_9153310_A_C |
| 75 | IL31RA_1 | 180_Thapsigargin_3 / 1372_Trametinib_1 / 159_HG6-64-1_3 | other / erk_mapk / erk_mapk | 4_20727343_G_C |
| 76 | PTP4A3_1 | 1007_Docetaxel_1 / 1372_Trametinib_1 / 1526_Refametinib_3 | cytoskeleton / erk_mapk / erk_mapk | X_92201459_T_G |
| 77 | MMP14_1 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk | 15_99729430_G_C |
| 78 | CAND2_3 | 1372_Trametinib_1 / 1526_Refametinib_3 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk | X_101102428_CT_C / X_101102205_C_G / X_101102212_T_C |
| 79 | ZNF292_5 | 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3 | other / erk_mapk / erk_mapk | 6_32027037_A_C / 12_130357070_A_C / 20_1445690_A_C / X_116441009_T_G / 5_40853381_T_G |
| 80 | EPSTI1_1 | 167_OSU-03012_3 / 1526_Refametinib_3 / 182_Obatoclax Mesylate_2 | pi3k / erk_mapk / apop | 2_226796327_T_C |
| 81 | CD97_5 | 1026_Tanespimycin_2 / 1372_Trametinib_1 / 1526_Refametinib_3 | other / erk_mapk / erk_mapk | 7_108514148_A_C / 12_108517007_T_G / 17_80137479_A_T / 5_141193109_A_G / 4_8036186_A_G |
| 82 | POLE4_5 | 1026_Tanespimycin_2 / 1526_Refametinib_3 / 1007_Docetaxel_1 | other / erk_mapk / cytoskeleton | 2_218618671_A_C / 16_72107293_C_G / 11_47315255_C_G / 21_46116692_T_G / 1_220001162_G_T |
| 83 | ZDHHC5_2 | 1372_Trametinib_1 / 1498_Selumetinib_2 / 1526_Refametinib_3 | erk_mapk / erk_mapk / erk_mapk | 7_101136942_T_G / 16_89729370_A_C |
| 84 | CAV1_1 | 1011_Navitoclax_2 / 211_TL-2-105_3 / 193_GW-2580_3 | apop / erk_mapk / rtk | 10_133626829_C_T |
| 85 | PRDM15_1 | 1114_Cetuximab_1 / 1372_Trametinib_1 / 1526_Refametinib_3 | egfr / erk_mapk / erk_mapk | 5_181333681_C_T |
| 86 | TXNL4A_1 | 1372_Trametinib_1 / 1026_Tanespimycin_2 / 1526_Refametinib_3 | erk_mapk / other / erk_mapk | 11_124397016_A_G |
| 87 | PITX1_1 | 1268_XAV939_3 / 1372_Trametinib_1 / 1526_Refametinib_3 | wnt / erk_mapk / erk_mapk | 10_43373649_C_A |
| 88 | CDCA5_1 | 1011_Navitoclax_2 / 269_NSC-207895_3 | apop / p53 | 2_217847583_C_T |
| 89 | S100A8_1 | 1377_Afatinib_1 / 1527_Pictilisib_2 | egfr / pi3k | 19_7746529_A_C |
| 90 | ZNF345_2 | 207_AS601245_3 / 1007_Docetaxel_1 | jnk_p38 / cytoskeleton | 6_53654807_C_T / 1_153772281_T_G |
| 91 | CXXC1_2 | 51_Dasatinib_1 / 1372_Trametinib_1 | abl / erk_mapk | 3_112199369_A_G / 2_119254595_G_A |
| 92 | ANO4_1 | 1526_Refametinib_3 / 1372_Trametinib_1 | erk_mapk / erk_mapk | 9_41294004_C_A |
| 93 | STAG2_1 | 1526_Refametinib_3 / 1372_Trametinib_1 | erk_mapk / erk_mapk | 3_10819431_A_G |
| 94 | PBX4_1 | 1011_Navitoclax_2 / 269_NSC-207895_3 | apop / p53 | 1_101786406_G_A |
| 95 | RRM1_1 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 2_217847583_C_T |
| 96 | NUPL1_2 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 19_11666277_T_C / 10_31363289_T_C |
| 97 | MCFD2_2 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 1_161518073_C_T / 1_161518227_T_C |
| 98 | IKBKAP_1 | 1011_Navitoclax_2 / 269_NSC-207895_3 | apop / p53 | 10_52768593_C_G |
| 99 | KHK_2 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 2_217847583_C_T / 2_217848003_A_G |
| 100 | SEMA4B_1 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 7_92469651_G_A |
| 101 | CEP41_1 | 1526_Refametinib_3 / 1372_Trametinib_1 | erk_mapk / erk_mapk | 13_36365551_C_T |
| 102 | DTX3L_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 4_185267219_TA_T |
| 103 | SMC2_1 | 1011_Navitoclax_2 / 269_NSC-207895_3 | apop / p53 | 15_62657955_G_C |
| 104 | HDAC6_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 13_45503246_G_A |
| 105 | KDM3A_1 | 1060_PD0325901_2 / 207_AS601245_3 | erk_mapk / jnk_p38 | 9_61211264_T_G |
| 106 | DCAKD_1 | 1011_Navitoclax_2 / 1248_Daporinad_3 | apop / metabol | 6_32183680_C_G |
| 107 | DUSP5_1 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 6_32183680_C_G |
| 108 | PRPF40A_2 | 301_PHA-793887_3 / 252_WZ3105_3 | cell_cyc / other | 4_189953012_G_A / 2_237772072_T_G |
| 109 | PPIB_4 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C / 15_59207967_A_G |
| 110 | ERAP2_2 | 1372_Trametinib_1 / 1026_Tanespimycin_2 | erk_mapk / other | 5_96986715_C_T / 5_96917400_T_C |
| 111 | BAALC_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 15_67236036_T_G |
| 112 | CACNA2D2_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 15_67236036_T_G |
| 113 | CNPY4_1 | 1377_Afatinib_1 / 288_WHI-P97_3 | egfr / other | 17_48728228_G_A |
| 114 | ANO5_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 12_9427796_G_T |
| 115 | KLK6_2 | 1372_Trametinib_1 / 288_WHI-P97_3 | erk_mapk / other | 4_48170249_G_A / 4_48170201_C_T |
| 116 | TNIP2_1 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 7_33099535_G_A |
| 117 | KCNJ11_4 | 1011_Navitoclax_2 / 293_Amuvatinib_2 | apop / rtk | 2_217847583_C_T / 2_217847883_G_A / 2_217848559_G_A / 2_217848003_A_G |
| 118 | MED14_1 | 193_GW-2580_3 / 269_NSC-207895_3 | rtk / p53 | 2_95859911_C_T |
| 119 | PDGFC_3 | 1026_Tanespimycin_2 / 1016_Temsirolimus_1 | other / tor | 5_150896225_C_T / 5_150898617_C_T / 5_150903222_T_C |
| 120 | SLFN12_2 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 1_241723452_T_C / 1_241723462_A_G |
| 121 | PDP1_5 | 1372_Trametinib_1 / 1377_Afatinib_1 | erk_mapk / egfr | 15_25189495_C_T / 15_25194819_G_A / 15_25199636_G_A / 4_87811722_A_G / 15_25185507_G_A |
| 122 | IER5L_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 9_34623341_A_G |
| 123 | ABCA5_2 | 1372_Trametinib_1 / 1026_Tanespimycin_2 | erk_mapk / other | 17_50677651_A_G / 17_78529677_G_C |
| 124 | CABP7_1 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 1_46344858_A_G |
| 125 | FCRLB_5 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 2_118982373_A_G / 17_81276033_A_C / X_132085721_T_C / 15_82463815_A_C / 9_41189241_T_C |
| 126 | TIGD3_1 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 5_135888024_G_T |
| 127 | ZNF295_1 | 159_HG6-64-1_3 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 11_113854221_T_C |
| 128 | PLD2_1 | 1114_Cetuximab_1 / 288_WHI-P97_3 | egfr / other | 15_84407910_G_A |
| 129 | CD55_1 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 5_113384951_C_A |
| 130 | QKI_3 | 1242_(5Z)-7-Oxozeaenol_3 / 1007_Docetaxel_1 | other / cytoskeleton | 6_87514446_T_C / 6_87612279_G_A / 6_87511385_T_C |
| 131 | MZT1_1 | 1011_Navitoclax_2 / 269_NSC-207895_3 | apop / p53 | 10_31363289_T_C |
| 132 | SEMA7A_1 | 1372_Trametinib_1 / 182_Obatoclax Mesylate_2 | erk_mapk / apop | 22_24253656_C_G |
| 133 | ROR2_1 | 1372_Trametinib_1 / 1377_Afatinib_1 | erk_mapk / egfr | 13_44436731_C_T |
| 134 | TRIP6_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 17_78529677_G_C |
| 135 | C14orf142_1 | 1242_(5Z)-7-Oxozeaenol_3 / 1378_Bleomycin(50uM)_1 | other / DNArep | 11_66055499_T_G |
| 136 | ZEB1_2 | 1377_Afatinib_1 / 1032_Afatinib_1 | egfr / egfr | 3_58285236_T_C / 9_41905830_C_G |
| 137 | NIP7_2 | 344_THZ-2-49_3 / 1007_Docetaxel_1 | cell_cyc / cytoskeleton | 9_33529025_G_T / 9_122724363_T_G |
| 138 | GNAO1_1 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 10_133626013_G_A |
| 139 | FGF9_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 13_32131648_A_G |
| 140 | SERINC3_1 | 1114_Cetuximab_1 / 1526_Refametinib_3 | egfr / erk_mapk | 2_25980839_T_G |
| 141 | RSBN1_1 | 1026_Tanespimycin_2 / 1372_Trametinib_1 | other / erk_mapk | 2_127286836_G_C |
| 142 | ARVCF_1 | 1011_Navitoclax_2 / 193_GW-2580_3 | apop / rtk | 10_133626829_C_T |
| 143 | DTL_1 | 269_NSC-207895_3 / 326_GSK690693_3 | p53 / pi3k | 2_29239654_G_A |
| 144 | SRSF7_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 5_181333681_C_T |
| 145 | IFIT5_2 | 1526_Refametinib_3 / 1372_Trametinib_1 | erk_mapk / erk_mapk | 6_169632990_G_A / 6_169665646_G_A |
| 146 | NARF_1 | 1007_Docetaxel_1 / 1526_Refametinib_3 | cytoskeleton / erk_mapk | 12_32328439_A_C |
| 147 | CASP8_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 17_75904383_G_C |
| 148 | IL17RB_1 | 1239_YK-4-279_3 / 1526_Refametinib_3 | other / erk_mapk | 19_44506064_G_T |
| 149 | SLC15A2_1 | 1377_Afatinib_1 | egfr | 2_174801578_A_G |
| 150 | SAR1B_1 | 193_GW-2580_3 | rtk | 5_155013898_A_G |
| 151 | TTC1_1 | 1011_Navitoclax_2 | apop | 5_155013898_A_G |
| 152 | CRP_2 | 165_DMOG_3 | other | 9_129834783_A_C / 17_69536247_A_G |
| 153 | GGCX_1 | 1011_Navitoclax_2 | apop | 19_39875355_A_T |
| 154 | SOX9_1 | 1066_AZD6482_2 | pi3k | 11_1092981_A_C |
| 155 | DLX5_3 | 1011_Navitoclax_2 | apop | 2_217847883_G_A / 2_217848003_A_G / 2_217847583_C_T |
| 156 | SNRNP25_3 | 1011_Navitoclax_2 | apop | 2_217847883_G_A / 2_217847583_C_T / 2_217848003_A_G |
| 157 | UHRF1BP1L_1 | 29_AZ628_3 | erk_mapk | 2_113594958_C_G |
| 158 | PAPD4_1 | 1011_Navitoclax_2 | apop | 19_54274840_G_A |
| 159 | ADAMTS14_1 | 1011_Navitoclax_2 | apop | 19_52554226_G_A |
| 160 | FAT2_1 | 1377_Afatinib_1 | egfr | 19_15807367_G_T |
| 161 | ZNF750_2 | 1377_Afatinib_1 | egfr | 19_15807367_G_T / 19_15794719_C_A |
| 162 | BTG2_1 | 1026_Tanespimycin_2 | other | 6_34872273_T_G |
| 163 | PIGB_4 | 1011_Navitoclax_2 | apop | 15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C / 15_59207967_A_G |
| 164 | WHAMM_4 | 1011_Navitoclax_2 | apop | 15_59207967_A_G / 15_59207979_A_G / 15_59207981_C_G / 15_59207987_T_C |
| 165 | PELI2_2 | 1011_Navitoclax_2 | apop | 9_114169457_C_T / 17_68420216_C_T |
| 166 | RPS5_1 | 302_PI-103_3 | pi3k | 10_89339873_T_C |
| 167 | DALRD3_1 | 1011_Navitoclax_2 | apop | 1_244857989_TA_T |
| 168 | ANKRD22_1 | 1372_Trametinib_1 | erk_mapk | 17_81206909_A_C |
| 169 | AGBL4_5 | 1011_Navitoclax_2 | apop | 2_217847883_G_A / 2_217848003_A_G / 2_217847583_C_T / 2_217842134_T_C / 2_217847379_A_G |
| 170 | DCUN1D2_1 | 1011_Navitoclax_2 | apop | 10_31363289_T_C |
| 171 | RAP2A_1 | 1011_Navitoclax_2 | apop | 10_31363289_T_C |
| 172 | TEX30_1 | 1011_Navitoclax_2 | apop | 10_31363289_T_C |
| 173 | CPNE8_1 | 1011_Navitoclax_2 | apop | X_24055660_C_A |
| 174 | IFIT3_1 | 1011_Navitoclax_2 | apop | 18_50806833_C_G |
| 175 | KCNMB2_1 | 1011_Navitoclax_2 | apop | 18_50806833_C_G |
| 176 | TRIM21_1 | 1011_Navitoclax_2 | apop | 18_50806833_C_G |
| 177 | NAP1L4_1 | 1011_Navitoclax_2 | apop | 12_27969552_T_A |
| 178 | GALNT3_1 | 1377_Afatinib_1 | egfr | 3_7680310_G_A |
| 179 | EVL_1 | 1011_Navitoclax_2 | apop | 7_33264495_A_G |
| 180 | TSPAN8_1 | 1242_(5Z)-7-Oxozeaenol_3 | other | 14_59565278_G_A |
| 181 | RUNDC3B_1 | 1011_Navitoclax_2 | apop | 4_68236279_G_GA |
| 182 | CCDC113_1 | 1054_Palbociclib_2 | cell_cyc | 16_67199408_A_C |
| 183 | PIAS2_2 | 1526_Refametinib_3 | erk_mapk | 18_49837560_A_G / 18_49837561_G_C |
| 184 | ALG14_1 | 1023_GW441756_3 | rtk | 12_27755086_G_GA |
| 185 | TAF11_1 | 1011_Navitoclax_2 | apop | 15_84516674_T_G |
| 186 | KCNK9_1 | 193_GW-2580_3 | rtk | 10_28880454_A_G |
| 187 | LRRC8A_1 | 1377_Afatinib_1 | egfr | 5_173158713_A_G |
| 188 | TMEM151B_1 | 1372_Trametinib_1 | erk_mapk | 9_67920363_C_T |
| 189 | C10orf76_1 | 1007_Docetaxel_1 | cytoskeleton | 2_169557387_G_GA |
| 190 | NXNL2_1 | 1007_Docetaxel_1 | cytoskeleton | 12_54002598_T_G |
| 191 | TCEB3_1 | 330_XMD13-2_3 | other | 14_67333008_A_G |
| 192 | CPEB2_2 | 266_Zibotentan_2 | other | 8_22102127_A_G / 8_22102128_C_T |
| 193 | TUBB_1 | 193_GW-2580_3 | rtk | 1_101786406_G_A |
| 194 | UBE2H_1 | 1011_Navitoclax_2 | apop | 2_9279286_C_T |
| 195 | TM9SF4_1 | 1526_Refametinib_3 | erk_mapk | 9_41294004_C_A |
| 196 | ZNF250_1 | 1011_Navitoclax_2 | apop | 5_135888024_G_T |
| 197 | ARSD_1 | 269_NSC-207895_3 | p53 | 1_101786406_G_A |
| 198 | ZBED5_5 | 1026_Tanespimycin_2 | other | 5_176529597_A_C / 14_69704655_C_T / 11_62807431_T_G / 7_99486962_A_C / 5_138430313_A_C |
| 199 | TEAD3_3 | 1011_Navitoclax_2 | apop | 18_166710_TTAAAA_T / 18_166819_T_C / 18_264012_G_A |
| 200 | PAICS_1 | 1377_Afatinib_1 | egfr | 19_50637249_G_A |
| 201 | SDSL_1 | 1026_Tanespimycin_2 | other | 3_31664157_C_T |
| 202 | SP140L_1 | 1011_Navitoclax_2 | apop | 19_9857463_G_A |
| 203 | VEZF1_1 | 1011_Navitoclax_2 | apop | 4_122258745_C_T |
| 204 | TSR2_2 | 1011_Navitoclax_2 | apop | 8_109271027_T_C / 8_109271124_T_G |
| 205 | LRFN5_1 | 1011_Navitoclax_2 | apop | 10_3165440_A_G |
| 206 | HMOX1_3 | 1026_Tanespimycin_2 | other | 1_183239405_G_A / 20_39018962_A_C / 2_86785910_T_G |
| 207 | OAF_2 | 1011_Navitoclax_2 | apop | 9_83978162_A_T / 9_83976942_T_C |
| 208 | C1orf198_1 | 193_GW-2580_3 | rtk | 20_6215106_T_C |
| 209 | RNF145_1 | 193_GW-2580_3 | rtk | 15_65447029_G_A |
| 210 | TFDP1_2 | 1011_Navitoclax_2 | apop | 10_31363289_T_C / 16_60358945_T_C |
| 211 | TRIM33_5 | 1026_Tanespimycin_2 | other | 5_176575310_A_C / 6_136362716_T_G / 4_78315728_T_G / 22_42516026_A_G / 12_14806481_T_G |
| 212 | BRD1_1 | 147_NSC-87877_3 | other | 5_154002958_G_A |
| 213 | RAB18_1 | 1011_Navitoclax_2 | apop | 3_146194512_C_T |
| 214 | DOK6_1 | 1011_Navitoclax_2 | apop | 18_12840880_T_C |
| 215 | TMEM132D_1 | 1011_Navitoclax_2 | apop | 1_89592683_G_GT |
| 216 | RBKS_1 | 1011_Navitoclax_2 | apop | 7_140126550_T_A |
| 217 | SDPR_1 | 1372_Trametinib_1 | erk_mapk | 15_23364667_T_G |
| 218 | HADHB_3 | 1011_Navitoclax_2 | apop | 19_48944320_G_A / 19_48944456_G_A / 19_48942517_C_T |
| 219 | RAB2B_1 | 1011_Navitoclax_2 | apop | 15_20251568_G_A |
| 220 | CLSPN_2 | 1011_Navitoclax_2 | apop | 15_62651935_A_G / 15_62657955_G_C |
| 221 | LRCH2_1 | 1372_Trametinib_1 | erk_mapk | 19_1825787_T_TA |
| 222 | RIC8B_1 | 1011_Navitoclax_2 | apop | 3_39412024_A_G |
| 223 | SNX17_1 | 1026_Tanespimycin_2 | other | 17_43879789_T_G |
| 224 | HPS1_3 | 1026_Tanespimycin_2 | other | 9_136463607_G_A / 9_136476782_G_A / 9_136453326_A_G |
| 225 | TNNT3_1 | 1377_Afatinib_1 | egfr | 2_226796327_T_C |
| 226 | MPHOSPH9_1 | 257_NPK76-II-72-1_3 | mitosis | 14_104949986_T_C |
| 227 | PCDH7_1 | 1372_Trametinib_1 | erk_mapk | 11_64284449_A_C |
| 228 | NSL1_1 | 193_GW-2580_3 | rtk | 3_75665457_C_T |
| 229 | ALG9_1 | 1011_Navitoclax_2 | apop | 14_76498312_C_T |
| 230 | PDE12_1 | 1006_Cytarabine_1 | DNArep | 1_161518073_C_T |
| 231 | PAPSS2_1 | 173_FH535_3 | other | 1_485270_G_A |
| 232 | ZFHX2_1 | 1011_Navitoclax_2 | apop | 9_27567147_C_T |
| 233 | TFG_2 | 1011_Navitoclax_2 | apop | X_16150554_T_C / X_16150344_T_C |
| 234 | IL15RA_1 | 1011_Navitoclax_2 | apop | 22_36566306_C_G |
| 235 | MBTD1_1 | 1248_Daporinad_3 | metabol | 22_36566306_C_G |
| 236 | TMPRSS4_1 | 1372_Trametinib_1 | erk_mapk | 11_18484085_G_A |
| 237 | APBB1_1 | 1011_Navitoclax_2 | apop | 7_117548606_ATG_A |
| 238 | MAD2L2_1 | 1011_Navitoclax_2 | apop | 7_117548606_ATG_A |
| 239 | MAP4_1 | 1011_Navitoclax_2 | apop | 7_33099535_G_A |
| 240 | GLTP_1 | 1377_Afatinib_1 | egfr | 2_182994745_T_C |
| 241 | CECR2_1 | 1011_Navitoclax_2 | apop | 15_30596563_A_G |
| 242 | RUFY1_1 | 1011_Navitoclax_2 | apop | 17_73212821_T_C |
| 243 | LRRN1_3 | 1372_Trametinib_1 | erk_mapk | 10_26492426_T_C / 4_654142_G_A / 14_67347493_A_C |
| 244 | ATRIP_1 | 1026_Tanespimycin_2 | other | 19_815835_G_A |
| 245 | NADKD1_1 | 1011_Navitoclax_2 | apop | 3_16323447_C_T |
| 246 | DAPL1_5 | 1026_Tanespimycin_2 | other | 15_78923063_A_C / 1_2588455_T_G / 20_32797074_C_A / 14_69704655_C_T / 17_7701545_A_C |
| 247 | HSD17B10_1 | 1011_Navitoclax_2 | apop | 5_24511259_C_T |
| 248 | CTSL1_5 | 1526_Refametinib_3 | erk_mapk | 7_6857531_A_G / 10_62069760_A_C / 17_80137479_A_T / X_52907336_A_C / 3_62493670_T_G |
| 249 | PPM1F_2 | 1031_Elesclomol_2 | other | 14_72893955_C_G / 16_29382935_T_G |
| 250 | SERPINB8_1 | 1248_Daporinad_3 | metabol | 6_69361281_G_A |
| 251 | LEPREL4_1 | 1011_Navitoclax_2 | apop | 19_11116804_A_C |
| 252 | HIRA_1 | 225_Genentech Cpd 10_3 | mitosis | 9_41341340_C_T |
| 253 | MET_2 | 1011_Navitoclax_2 | apop | 10_133626013_G_A / 10_133626012_T_A |
| 254 | ST18_2 | 1011_Navitoclax_2 | apop | 10_133626012_T_A / 10_133626013_G_A |
| 255 | IFI35_1 | 1372_Trametinib_1 | erk_mapk | 12_15589379_GA_G |
| 256 | CNKSR3_1 | 1166_QL-VIII-58_3 | tor | 17_78539866_T_C |
| 257 | NFKBIZ_1 | 1372_Trametinib_1 | erk_mapk | 6_47579334_T_TAA |
| 258 | TFPI_1 | 1372_Trametinib_1 | erk_mapk | 6_47579334_T_TAA |
| 259 | PDIA6_1 | 1011_Navitoclax_2 | apop | 11_17498150_C_G |
| 260 | RSF1_3 | 1026_Tanespimycin_2 | other | 8_143870873_T_G / 1_54986510_A_C / 12_14806481_T_G |
| 261 | MYO1E_2 | 1372_Trametinib_1 | erk_mapk | 15_25170856_G_A / X_153670877_G_T |
| 262 | UBAP1_1 | 1372_Trametinib_1 | erk_mapk | 5_31510999_G_T |
| 263 | GFER_1 | 1026_Tanespimycin_2 | other | 2_85639407_A_C |
| 264 | C17orf75_1 | 211_TL-2-105_3 | erk_mapk | 6_32183680_C_G |
| 265 | TTC9B_1 | 1011_Navitoclax_2 | apop | 17_74541739_G_A |
| 266 | FAM198B_1 | 211_TL-2-105_3 | erk_mapk | 6_106519310_A_C |
| 267 | DCTD_1 | 1026_Tanespimycin_2 | other | 8_7429219_C_T |
| 268 | ZSCAN16_1 | 1011_Navitoclax_2 | apop | 7_26185482_G_A |
| 269 | CCDC14_2 | 1372_Trametinib_1 | erk_mapk | 7_33357933_C_A / 9_33529025_G_T |
| 270 | TRIP11_1 | 1011_Navitoclax_2 | apop | 1_230792766_C_G |
| 271 | NKAIN2_1 | 1011_Navitoclax_2 | apop | 1_169804019_T_C |
| 272 | NT5E_1 | 1011_Navitoclax_2 | apop | 1_169804019_T_C |
| 273 | PPP1R14A_5 | 196_Phenformin_3 | metabol | 15_57438247_A_C / 5_76209739_T_G / X_149774713_G_C / 1_35479062_T_G / 9_109406442_T_C |
| 274 | CDH2_1 | 1241_CHIR-99021_3 | wnt | 1_155060858_G_A |
| 275 | EMC3_1 | 151_QS11_3 | other | 1_197039467_A_C |
| 276 | NCAPG2_1 | 6_PHA-665752_3 | rtk | 1_149021276_A_C |
| 277 | OR13H1_2 | 166_FTI-277_3 | other | 2_201728736_A_G / 2_201723527_C_T |
| No. | FRH | Var_Exp(pval) | Var_Drug(pval) | Exp_Drug(pval) | Ave_VarDrug(pval) | Rank |
| 1 | POLR3K_5 | 1.67E-06 | 7.55E-05 / 9.21E-05 / 0.000406169 / 0.000572894 / 0.000596706 / 0.000830024 / 0.000897369 / 0.000943017 / 0.00100282 / 0.001405937 / 0.001436612 / 0.001463281 / 0.001585317 / 0.00161475 / 0.001676489 / 0.001964123 / 0.00196632 / 0.002055398 / 0.002082114 / 0.002155282 / 0.002396859 / 0.00278744 / 0.002914256 / 0.002947382 / 0.003272641 / 0.003463499 / 0.00367462 / 0.00367676 / 0.003769026 / 0.003782462 / 0.004059938 / 0.004512707 / 0.005161898 / 0.005787569 / 0.006314892 / 0.006945435 / 0.008072051 / 0.008410403 / 0.008931324 | 0.001531019 / 0.057569018 / 0.249595562 / 0.085576027 / 0.000387243 / 1.59E-05 / 0.059525284 / 0.863014405 / 0.249659436 / 0.124147024 / 0.000281163 / 7.11E-06 / 0.019500847 / 0.695397999 / 0.001918781 / 0.086727092 / 0.023202587 / 0.000441974 / 0.000350217 / 6.89E-05 / 0.594643715 / 0.036578315 / 0.000474321 / 0.011974306 / 0.079370245 / 0.828009563 / 0.010696272 / 0.005232793 / 0.582545022 / 0.058088741 / 0.00262003 / 0.049789754 / 0.228619231 / 0.001174198 / 7.02E-05 / 1.63E-06 / 0.295541863 / 7.79E-06 / 3.75E-05 | 2.97E-03 | 39 |
| 2 | FAM114A1_1 | 0.0000025505 | 0.0042694104092888974 / 0.00020876871631167866 / 0.0007568114081113288 / 0.0035305946391629545 / 0.008363870991709823 / 1.4383640936438872e-05 / 7.009824754153582e-05 / 0.0035938658204617215 / 0.006293754132220173 / 0.0032074496683567847 / 0.020401954406182556 / 0.0003542511072244001 | 1.985359164220784e-08 / 1.9619211144338805e-07 / 1.1786246361826978e-07 / 1.2984459856816525e-07 / 6.679222855070028e-07 / 7.60276325486698e-06 / 4.381181635105041e-08 / 3.0395531368179466e-06 / 3.92186793718892e-06 / 1.4410681857864534e-05 / 2.2310227467645046e-05 / 6.449074536371506e-07 | 0.004255434 | 12 |
| 3 | AVPI1_1 | 0.0000003933 | 0.0006396902026437372 / 0.0035535295006568564 / 0.004142441090345042 / 0.008737166819403942 / 0.005365726625203914 / 0.016265715773138612 / 0.041737910661353794 / 0.03071155447434498 / 0.012033224729341468 / 0.013915501344307473 / 0.009991096973902677 / 0.01939906554836552 | 8.724099353866297e-18 / 4.327010736165959e-17 / 8.775781672799915e-14 / 3.5651532383955547e-13 / 2.396709082503607e-12 / 5.521480171031492e-10 / 1.2559804874872373e-08 / 2.0783114956254993e-07 / 4.311397020221965e-08 / 2.2998188297812146e-05 / 5.132866263479021e-07 / 2.0389575690868755e-07 | 0.013874385 | 12 |
| 4 | S100A11_1 | 0.0000007141 | 0.0002735997430699673 / 0.006564850275482538 / 0.00042414739039363294 / 0.029067524880234556 / 0.0227837453875734 / 0.0013348733587389963 / 0.025661191456139584 / 0.030326580226023813 / 0.01355699403064558 / 0.004313726310163241 / 0.0095400572561103 / 0.04535245933148631 | 6.393329432968863e-16 / 1.2307435361378187e-13 / 2.466858890049804e-13 / 5.545342625838226e-09 / 1.0380326612394311e-08 / 2.3437239888960063e-09 / 1.3417028235666536e-07 / 4.443975040006529e-07 / 9.063384713333984e-07 / 1.1118101978147603e-06 / 2.049520010016173e-06 / 4.414454919747786e-06 | 0.015766646 | 12 |
| 5 | TMEM92_2 | 0.0000000001 | 8.127905920870596e-06 / 0.03825717382100051 / 0.03457460632857845 / 0.004853137512524773 / 0.03388689864411195 / 0.008814758212945951 / 0.03578088316319923 / 0.006217130934294085 / 0.00017355910676635736 / 0.0280335961707743 / 0.0017388474926662016 / 0.00012460830831951075 | 2.4261531255663892e-11 / 5.0311269179717914e-11 / 2.4975316917871734e-10 / 2.042638151066576e-07 / 1.5566664880019958e-10 / 5.680894385767319e-06 / 1.6699000588343938e-06 / 6.566036837900111e-06 / 3.420597261413642e-07 / 8.237906153677492e-07 / 9.263610563311242e-07 / 1.2428063696083114e-06 | 0.016038611 | 12 |
| 6 | ATP6V0B_1 | 0.0000017465 | 0.00016551876926533193 / 0.015335407229032524 / 0.0076626373197674 / 0.028777417252359768 / 0.026082796942956787 / 0.0389316131443371 / 0.0004915314263603532 / 0.0014839424825817675 / 0.022837697585243923 / 0.01178531426696526 / 0.00988329756179177 / 0.031727625216694644 | 2.401602140750141e-13 / 4.8650677089433124e-11 / 3.9493836034696935e-10 / 7.33482261725945e-09 / 2.8535418288695915e-08 / 2.096326058421669e-09 / 1.5659535702420375e-08 / 3.964614244828257e-07 / 1.7237698783914587e-07 / 3.2415943673340482e-06 / 6.164017172502494e-08 / 3.4316628105398186e-07 | 0.016263733 | 12 |
| 7 | GBP1_1 | 0.0000405829 | 0.04015481753439807 / 0.018576825788521975 / 0.01852560134227437 / 0.002373869363376313 / 0.02782754766981264 / 0.002415619395480455 / 0.011881237105466349 / 0.00033563208340305035 / 0.005055991739999371 / 0.008903270762925434 | 1.187415764241114e-11 / 6.095615889440819e-11 / 1.917288218821707e-12 / 5.619391245841771e-08 / 1.1719944005143196e-08 / 1.0794280052002033e-07 / 5.9596304962709845e-08 / 0.0004931619081689741 / 9.495988028273389e-08 / 1.1666929391578053e-06 | 0.013605041 | 10 |
| 8 | ERLEC1_1 | 0.0000005719 | 3.075536174342061e-06 / 0.012665982332335715 / 2.1913337236976437e-05 / 7.482707136703458e-05 / 2.6075431224558473e-05 / 5.690512097896811e-05 / 0.0020110917770508187 / 0.0009108241993284896 / 9.402887850421925e-06 | 8.155050086866359e-08 / 8.547376478456365e-07 / 4.650557832871856e-07 / 1.979425060398104e-07 / 9.659100942891217e-07 / 1.5727836576660756e-05 / 2.4902482384647638e-06 / 5.963679135141154e-06 / 0.0002870787007736368 | 0.001753344 | 9 |
| 9 | SSH3_1 | 0.0000007635 | 0.0035447981156988204 / 0.0020476470911988563 / 0.0043734414976099745 / 0.00442890244448457 / 0.0016646475834734644 / 0.003469684588834184 / 0.016258281480713958 / 0.007203498668728194 / 0.008481086009715616 | 1.2839817776716313e-11 / 2.1456295745112202e-09 / 7.804965919854057e-11 / 1.0846113597262452e-10 / 8.402308355591066e-09 / 4.0629325207940226e-07 / 3.407462995284017e-05 / 4.726367578576213e-06 / 2.5541465321521183e-06 | 0.00571911 | 9 |
| 10 | TRIP10_1 | 0.0000173218 | 0.008943680317061822 / 0.0013412546793620756 / 0.0015773645986452735 / 0.007477694270383053 / 0.03117319702966703 / 0.03615921936711382 / 0.0031899243253359325 / 0.01485798676987582 / 0.03709204807398679 | 2.967675338863489e-16 / 1.3369912839925863e-16 / 9.67218561771649e-13 / 1.6290794365229653e-10 / 7.687956044278108e-10 / 4.534964360985728e-09 / 5.405201490429158e-09 / 7.483583479891572e-09 / 6.363635419128828e-06 | 0.01575693 | 9 |
| 11 | MAN1B1_5 | 0.0000014304 | 0.0023856498203327875 / 7.812266726494329e-05 / 0.027952944492863622 / 0.005617959119750928 / 0.002644793270745064 / 0.012381465875087235 / 0.0074542403283965625 / 0.001546432706758083 | 1.868937111544232e-10 / 1.6531442166915098e-08 / 9.414450468098132e-09 / 7.030425208487326e-08 / 4.773344609707843e-08 / 3.1813403816802826e-08 / 1.2054478070790373e-06 / 5.5556733765270095e-06 | 0.007507701 | 8 |
| 12 | CD151_2 | 0.0000016613 | 0.002828971924250992 / 0.0020308786555996105 / 0.0037139272628794475 / 0.0008147078915095311 / 0.0027987535750038264 / 0.03156448872153919 / 0.006216893575679977 / 0.012774860953989628 | 1.3495328256839188e-12 / 1.6512296821172123e-12 / 3.6414648280531383e-13 / 2.006846342245524e-10 / 9.201808809340132e-08 / 5.931180856539697e-07 / 3.000290377999784e-07 / 5.940973440824346e-07 | 0.007842935 | 8 |
| 13 | PDLIM7_1 | 0.0000151792 | 0.0017419308016053887 / 0.01703591045996455 / 0.010263742478054323 / 0.0074877120166343125 / 0.003951752871247063 / 0.023461658690951844 / 0.0007060714810871347 / 0.00993017974219656 | 1.4890466266195927e-09 / 1.3930872632280484e-10 / 4.042121027066677e-08 / 5.515991658674008e-07 / 3.206759648352692e-09 / 7.38168534365637e-08 / 1.2279749259117268e-08 / 1.6868345203620706e-07 | 0.00932237 | 8 |
| 14 | GLIPR1_1 | 0.0000014611 | 0.008133825444941598 / 0.0005214752415830771 / 0.01773178574837757 / 0.009430350367584172 / 0.01955380058568292 / 0.003589646250229098 / 0.0015918099299812008 / 0.021268808314233105 | 1.4019555545362636e-10 / 1.3355121304727163e-10 / 5.96825464847569e-10 / 7.437295967997082e-09 / 2.751586429438836e-09 / 5.123469233147485e-08 / 4.827912592803016e-07 / 9.24174412768079e-06 | 0.010227688 | 8 |
| 15 | GPR87_1 | 0.0000006448 | 0.0076251167073391945 / 0.0028222416161458853 / 0.033262979309241485 / 0.0006381430782712855 / 0.0019094505299096247 / 0.018260880298473985 / 0.003923489922251829 / 0.014606068770244599 | 7.534055709544274e-17 / 2.585655261990035e-15 / 5.2335156402490275e-15 / 2.4905394673635635e-09 / 2.579143491051842e-10 / 3.3024470123206265e-08 / 2.0302747016952384e-07 / 3.115039621495257e-06 | 0.010381046 | 8 |
| 16 | SNAP25_1 | 0.0000076174 | 0.0018807133849514282 / 0.0021339409269866432 / 0.008547140700416327 / 0.007837425491160097 / 0.0018204809165742553 / 0.01250093546784304 / 0.029444897497836964 / 0.025484654242891817 | 1.4208036186314184e-16 / 1.5507536243084707e-13 / 1.696952191969015e-11 / 1.009604302429168e-09 / 1.0410206618966501e-09 / 1.850497353460836e-09 / 1.0634082068029867e-08 / 1.0722107820456968e-07 | 0.011206274 | 8 |
| 17 | FGFBP1_2 | 0.0000000001 | 0.00017601864871485512 / 0.0005070210241593581 / 0.004411629733717425 / 0.008689109920315017 / 0.00019506735122442717 / 0.009640097626965513 / 0.006852417553255793 | 1.9060720081271283e-13 / 3.122850645863472e-09 / 4.1994336271257894e-10 / 6.0155643158720954e-09 / 3.843362175544889e-08 / 8.712480724022447e-06 / 1.9248384673484406e-07 | 0.004353052 | 7 |
| 18 | CHN1_1 | 0.0000025565 | 0.0014573918997663137 / 0.008577741421710208 / 0.001198103041045066 / 0.001533522936452515 / 0.0033634941504627697 / 0.010785244262186303 / 0.0373128898832142 | 6.175453097411747e-15 / 1.0898537184801719e-12 / 4.243100156030503e-12 / 2.3893328777750658e-08 / 3.7113695617625286e-08 / 1.3950404315566743e-06 / 4.353340320251518e-07 | 0.009175484 | 7 |
| 19 | ACSF2_4 | 0.0000126680 | 0.002287441661560721 / 0.002739732144211229 / 0.010839213238666172 / 0.02699935544242534 / 0.006587582753649601 / 0.020104758213330888 / 0.0037867420062336647 | 1.6018264558328353e-11 / 1.350522100376996e-10 / 3.533719025417417e-08 / 9.421341247634894e-07 / 6.358471973834479e-06 / 0.0005708652264651822 / 2.8573976842147612e-05 | 0.010477832 | 7 |
| 20 | SNAPC3_1 | 0.0000014845 | 0.003808062774578335 / 0.03330161757206289 / 0.001267397044740127 / 0.025490833026200553 / 0.005752102707973715 / 0.010531169902390105 / 0.02097227539629169 | 4.138352317586387e-12 / 6.324952413663082e-12 / 2.3039595587795142e-11 / 4.135749382360492e-09 / 2.943942798609411e-09 / 4.785025404402047e-07 / 8.45468021727955e-07 | 0.014446208 | 7 |
| 21 | ZFP82_1 | 0.0000002911 | 0.026193133649308403 / 0.002880197932827539 / 0.000892065314189748 / 0.03621760269335816 / 0.001409066709832824 / 0.03632632282612366 / 0.001597966657771602 | 2.1821058503470977e-07 / 2.1345284484994668e-07 / 1.6940360882868594e-06 / 2.332116712137168e-06 / 7.078139307433867e-06 / 4.932653487474453e-06 / 5.57905665828971e-06 | 0.015073765 | 7 |
| 22 | OPHN1_1 | 0.0002612099 | 0.04894666674267963 / 0.003544372498506248 / 0.03445218818410945 / 0.029417648259261447 / 0.01144054174070861 / 0.030599292085887794 / 0.003150128220025032 | 2.2816161503286945e-09 / 5.483877356966662e-07 / 6.645530643543907e-07 / 1.1508399694576279e-07 / 2.1220867950204813e-06 / 1.0055030736784958e-05 / 8.336038812610863e-05 | 0.023078691 | 7 |
| 23 | TNS3_1 | 0.0000006277 | 0.009569659528755218 / 0.0013302955859364471 / 0.0037548210952919408 / 0.0024792131341982242 / 0.003608716025393357 / 0.002638008434399487 | 8.722976186020636e-08 / 1.7164630812419945e-08 / 1.770632094332526e-08 / 1.9486556735289747e-07 / 4.0623560474101545e-07 / 5.860863385843348e-07 | 0.003896786 | 6 |
| 24 | P2RY6_5 | 0.0000010436 | 0.0009804545262469449 / 0.0013446510229950341 / 0.003789065107490644 / 0.006218322225340153 / 0.03645229771138508 / 0.01562975702849699 | 1.576709465685621e-13 / 2.5331252718662176e-10 / 2.3521007770880894e-07 / 2.3770553645092087e-10 / 1.368096065972398e-07 / 2.5418800842381177e-07 | 0.010735758 | 6 |
| 25 | SCO2_3 | 0.0000000001 | 0.01546077257784758 / 0.001964618656338199 / 0.0033965914999294854 / 0.012145502525993949 / 0.030055718710212946 / 0.013950769826858294 | 8.014599938246778e-09 / 1.8636695061114395e-08 / 3.705794897358954e-08 / 4.2936074352856663e-07 / 5.584053250118188e-05 / 2.397206724754045e-07 | 0.012828996 | 6 |
| 26 | KHSRP_1 | 0.0000003011 | 0.010352775099646664 / 0.019182484865138457 / 0.015100022601522628 / 0.01700255170966236 / 0.023101003520372643 / 0.006776149448547382 | 2.8490498620729386e-09 / 5.206538616416615e-10 / 1.4824605802962609e-08 / 7.704856226971619e-07 / 5.512137468127689e-07 / 3.2143315687611383e-06 | 0.015252498 | 6 |
| 27 | TTC3_1 | 0.0000002043 | 0.021976203067763718 / 0.014404186233262522 / 0.010065328958198384 / 0.005185630347493037 / 0.01771094219397329 / 0.026010950792548747 | 1.903714561147216e-10 / 1.8998104659295357e-09 / 8.134060967771899e-10 / 7.905696358239668e-09 / 1.7016664284191773e-06 / 2.3041895625093597e-07 | 0.015892207 | 6 |
| 28 | STEAP1_1 | 0.0000029634 | 0.013036283678806082 / 0.015688398206555057 / 0.006349160970663491 / 0.03777942745740614 / 0.010550376036332488 / 0.017877825906191358 | 6.761435756061347e-12 / 2.4207465935628376e-11 / 3.564533224675541e-12 / 4.401553310565403e-08 / 1.2935469598692122e-07 / 1.118837878226449e-05 | 0.016880245 | 6 |
| 29 | RNF207_2 | 0.0000000000 | 0.010918237443275771 / 0.010043999800272532 / 0.007055519329675997 / 0.027127865042923947 / 0.036896549219609824 / 0.015551929442979676 | 2.026443768844747e-13 / 1.0452530817759512e-11 / 3.4953412148396826e-12 / 2.417587221451319e-08 / 4.833952724825644e-07 / 6.916720467647325e-07 | 0.01793235 | 6 |
| 30 | C16orf59_2 | 0.0000011638 | 0.0017105849166402373 / 0.008006011161483364 / 2.877198249929341e-05 / 0.00044269902702600075 / 0.0035960656357070827 | 8.710873698386588e-07 / 1.6466535184566052e-06 / 3.1826237601737307e-06 / 1.5852069704631895e-05 / 5.3568783395819636e-05 | 0.002756827 | 5 |
| 31 | ICAM1_1 | 0.0000008958 | 0.0006371740222421855 / 0.0004238045362036801 / 0.004627658102704232 / 0.0017187301776334363 / 0.0141342657951169 | 5.301958232122965e-10 / 5.691310460319534e-10 / 9.501545566679268e-08 / 7.484161653079297e-07 / 1.0741352344507851e-05 | 0.004308327 | 5 |
| 32 | POLE_1 | 0.0000006233 | 0.00020876871631167866 / 1.4383640936438872e-05 / 0.010067369603256736 / 0.012703084299864359 / 0.0035305946391629545 | 4.564149862726603e-11 / 4.031853969284765e-09 / 2.1715096143998947e-09 / 5.185675527716179e-08 / 9.417769469553245e-08 | 0.00530484 | 5 |
| 33 | MYT1_3 | 0.0000018757 | 0.0003180382059133217 / 0.008006011161483364 / 2.877198249929341e-05 / 0.022477574071905464 / 0.002087164867003088 | 1.3185457834679754e-09 / 1.0046430313676016e-07 / 8.61285349137364e-07 / 5.400726736519221e-07 / 1.926503424303301e-05 | 0.006583512 | 5 |
| 34 | MMRN2_1 | 0.0000020377 | 0.0006381430782712855 / 0.0028222416161458853 / 0.0076251167073391945 / 0.003923489922251829 / 0.033262979309241485 | 1.858452443514514e-05 / 1.5622701951466016e-05 / 3.730943185783191e-05 / 0.0001274335060935434 / 0.0007602117674326636 | 0.009654394 | 5 |
| 35 | ZNF420_1 | 0.0000000763 | 0.00765254728362311 / 0.02761664002677436 / 0.005704138976540187 / 0.0062144909889472 / 0.02210665467937813 | 2.2557919455927213e-08 / 3.8434441624955556e-08 / 4.143652073206543e-08 / 8.451473540512692e-07 / 4.161971954576053e-06 | 0.013858894 | 5 |
| 36 | ELOVL1_2 | 0.0000041883 | 0.005612639115469282 / 0.004888298105885152 / 0.008969805039998042 / 0.030404112516122277 / 0.03243772518292004 | 3.522904480656644e-10 / 4.32348036263409e-10 / 1.2293459738289953e-08 / 1.8913948776318332e-08 / 2.54997287465458e-07 | 0.016462516 | 5 |
| 37 | CHGB_1 | 0.0000004668 | 0.01797077169605779 / 0.01038558151359997 / 0.03995334833105726 / 0.001300447845463061 / 0.02829515218286432 | 1.9938343577981134e-14 / 2.978187999752288e-14 / 0.0001540200268173068 / 6.798337935097158e-05 / 2.4772197524644612e-08 | 0.01958106 | 5 |
| 38 | MLKL_1 | 0.0000005037 | 0.04557109838009256 / 0.020065293234851133 / 0.018782542562548483 / 0.0028710845896819668 / 0.0151749944268713 | 5.258350011749314e-16 / 3.5233765431361435e-16 / 1.4380692845318856e-14 / 1.6150676172067693e-09 / 2.4525625560555298e-05 | 0.020493003 | 5 |
| 39 | FEZ2_1 | 0.0000017550 | 0.031477193589555245 / 0.024379882961236787 / 0.010048470855366752 / 0.011748468267345573 / 0.03714879584420702 | 6.312935617277429e-10 / 3.7842287030008046e-08 / 2.4657689745274255e-07 / 3.08973568823383e-07 / 2.749086098138227e-07 | 0.022960562 | 5 |
| 40 | ADNP2_1 | 0.0000001922 | 0.0026926894174448815 / 0.004075435458657517 / 0.0019491268114425514 / 0.001327102464026624 | 1.2225480672529466e-06 / 3.0317781765339874e-07 / 5.119644519453932e-07 / 6.547354475139775e-07 | 0.002511089 | 4 |
| 41 | CES2_1 | 0.0000000854 | 0.0011256917008427522 / 0.00029984671915346143 / 0.0069928898567800275 / 0.0037176072866771754 | 5.386350021831899e-08 / 4.097431696633607e-08 / 3.300361146039448e-07 / 2.3865798857407134e-08 | 0.003034009 | 4 |
| 42 | DDR1_2 | 0.0000037846 | 0.005811854132542747 / 0.00015027886843801155 / 0.015373655199800797 / 0.010222251543950407 | 1.3359340041312337e-07 / 0.0004586184985847102 / 3.181191463640303e-05 / 2.4848821642062066e-05 | 0.00788951 | 4 |
| 43 | PTGR1_1 | 0.0001294867 | 0.000974029004631184 / 0.010347970561211065 / 0.0033011167578337673 / 0.017006970232444858 | 3.75794293906824e-10 / 2.742804006281166e-10 / 6.771606681956264e-10 / 4.371488301831706e-09 | 0.007907522 | 4 |
| 44 | LIN7A_1 | 0.0000001378 | 0.0003053911694309243 / 0.0008478272697591876 / 0.02960036890335299 / 0.00505471841056208 | 6.44051592787778e-15 / 1.6309672669483183e-12 / 5.867966338897064e-09 / 9.118314699470778e-11 | 0.008952076 | 4 |
| 45 | SYNCRIP_1 | 0.0000002054 | 0.00032880733436267256 / 0.011951324766386422 / 0.0027159743199694653 / 0.02902955003102947 | 3.348316142238797e-07 / 1.9514280045818426e-06 / 2.6301830086705713e-07 / 7.532993598712855e-08 | 0.011006414 | 4 |
| 46 | EREG_1 | 0.0000004009 | 0.013036283678806082 / 0.015688398206555057 / 0.010550376036332488 / 0.006349160970663491 | 3.9566088865499e-12 / 3.2858827273117755e-10 / 7.373790642942721e-08 / 1.7082322019514156e-10 | 0.011406055 | 4 |
| 47 | C12orf57_1 | 0.0000023046 | 0.028957927563687466 / 0.010155427409165514 / 0.002911658631725467 / 0.01482122652336213 | 5.418786155576515e-08 / 9.894747993886977e-09 / 1.0898528564578497e-05 / 9.693695439206281e-06 | 0.01421156 | 4 |
| 48 | PARP9_1 | 0.0000003928 | 0.014588245785000514 / 0.004624429303044866 / 0.027918024199514987 / 0.010739324225736034 | 1.0885372638586847e-06 / 2.7399829900956533e-05 / 1.1332635442176465e-05 / 0.0019394426591983717 | 0.014467506 | 4 |
| 49 | SLITRK3_1 | 0.0000015095 | 0.008527348662485085 / 0.005576784085290364 / 0.03856475377208919 / 0.017395831116316804 | 4.879058800869575e-10 / 6.089275055540338e-08 / 8.719955641574723e-08 / 1.2488572217128136e-07 | 0.017516179 | 4 |
| 50 | BIRC7_2 | 0.0000002867 | 0.007821970573183347 / 0.012845369111074686 / 0.031890899198805917 / 0.02364396066164544 | 1.415313199875648e-06 / 1.6775105441448168e-06 / 2.9271097438840027e-06 / 4.809721198171681e-07 | 0.01905055 | 4 |
| 51 | ID4_1 | 0.0000000438 | 0.003637438547469328 / 0.0035281538483017986 / 0.03136639803264472 / 0.038599008286505046 | 4.0717260162829775e-06 / 6.566951490305026e-08 / 3.5276667485857833e-07 / 7.44565437001132e-08 | 0.01928275 | 4 |
| 52 | NUCB2_1 | 0.0000017255 | 0.015046780105136083 / 0.0032323812044334427 / 0.04240343926485064 / 0.017505946985290035 | 8.68516823257589e-12 / 1.202306983296894e-07 / 1.0709464975577815e-07 / 3.127569243193228e-07 | 0.019547137 | 4 |
| 53 | PDLIM1_2 | 0.0000001037 | 0.015202424481940903 / 0.012748370693134645 / 0.04063751247586265 / 0.022091540973998933 | 3.14173143142748e-08 / 3.6190255834565276e-06 / 3.7940179795671547e-06 / 4.77087797249951e-05 | 0.022669962 | 4 |
| 54 | RNF219_3 | 0.0000000003 | 0.02634863692985202 / 0.03450099983593556 / 0.03513681089329 / 0.015137129753690677 | 7.261409909964612e-07 / 8.200694456053606e-07 / 4.0053825877934606e-07 / 8.023087556208056e-05 | 0.027780894 | 4 |
| 55 | CTRB2_1 | 0.0002930973 | 0.020496866256864702 / 0.028972592148966015 / 0.032049126216131416 / 0.03681214620084693 | 1.3405501486551371e-06 / 6.226524992191516e-06 / 1.1541305382124772e-05 / 0.003046643299819599 | 0.029582683 | 4 |
| 56 | RAB31_2 | 0.0000000104 | 0.006725175164160767 / 0.048022618740457663 / 0.04103625170396066 / 0.04997722883556261 | 8.150539694234232e-13 / 2.883168259855219e-11 / 1.4028815753928321e-09 / 3.0146813286497465e-07 | 0.036440319 | 4 |
| 57 | INADL_2 | 0.0000000214 | 0.0001704720932348638 / 0.001471900435167172 / 0.002014853091681951 | 0.00015166172573858843 / 6.189932841020127e-05 / 0.0012577263128842932 | 0.001219075 | 3 |
| 58 | DPYSL4_5 | 0.0000005775 | 0.0014690065976330497 / 0.00012135998144774518 / 0.002693760101625894 | 4.6411634719532725e-08 / 2.317754511202282e-05 / 4.294994611664571e-05 | 0.001428042 | 3 |
| 59 | TMEM71_1 | 0.0000627736 | 0.004627658102704232 / 0.0006371740222421855 / 0.0004238045362036801 | 1.0813921624882114e-08 / 2.619185841833522e-07 / 1.5188016611726219e-06 | 0.001896212 | 3 |
| 60 | TPD52L2_1 | 0.0000003037 | 0.000823176823593811 / 0.0007924860430472411 / 0.004187597686372937 | 3.758054827561048e-09 / 6.425156679903907e-10 / 1.2757355615837679e-08 | 0.00193442 | 3 |
| 61 | PDIA3_2 | 0.0000000000 | 5.0723783667581744e-05 / 0.009226267029946443 / 0.0017778259882067805 | 4.9831579429374996e-06 / 1.3486634691146526e-07 / 1.5338596718321366e-05 | 0.003684939 | 3 |
| 62 | KCNK6_1 | 0.0000030974 | 0.0014573918997663137 / 0.008577741421710208 / 0.001198103041045066 | 2.061544572083878e-08 / 3.896450174169792e-08 / 5.769947340059933e-08 | 0.003744412 | 3 |
| 63 | CASP8AP2_2 | 0.0000000219 | 0.007099092180854751 / 0.0001545053835362215 / 0.00595076253249461 | 2.3414789029943654e-08 / 6.895486056880935e-08 / 3.937778269227827e-06 | 0.004401453 | 3 |
| 64 | LIG1_2 | 0.0000029926 | 0.00035665903643679 / 2.5410658402422594e-05 / 0.014175997822512453 | 2.1508604917775794e-09 / 1.880923327455265e-08 / 1.4976701341341075e-07 | 0.004852689 | 3 |
| 65 | ARVCF_1 | 0.0000000809 | 0.001267397044740127 / 0.003808062774578335 / 0.01865963988831641 | 3.633196454799821e-07 / 1.9057080324447833e-06 / 7.799389653993747e-07 | 0.0079117 | 3 |
| 66 | PPP1R13L_1 | 0.0000006399 | 0.026512261541912406 / 8.131569425129391e-05 / 1.125309447182209e-05 | 2.5138651999817746e-07 / 6.409504618492529e-08 / 2.5997819819707715e-07 | 0.008868277 | 3 |
| 67 | ELL2_1 | 0.0000000404 | 0.0018371780594793963 / 0.02029407943779478 / 0.005548792280102234 | 2.455332869218628e-08 / 3.107620037340903e-07 / 5.894237364187611e-06 | 0.009226683 | 3 |
| 68 | TMEM74_1 | 0.0000000714 | 0.01038558151359997 / 0.01797077169605779 / 0.001300447845463061 | 1.1935648767376756e-12 / 3.737531077554552e-12 / 0.00012280075259138036 | 0.0098856 | 3 |
| 69 | SH3KBP1_1 | 0.0000012067 | 0.012901388332189151 / 0.011880485771633283 / 0.005801481063585688 | 5.030397982975877e-06 / 9.894710679501381e-06 / 3.451000359467373e-05 | 0.010194452 | 3 |
| 70 | AGXT2L2_4 | 0.0000000778 | 0.000513024270655123 / 0.030480389193308928 / 3.516928306401037e-05 | 1.0557144142948509e-10 / 9.649265913114177e-08 / 2.335866075829399e-06 | 0.010342861 | 3 |
| 71 | FLNA_1 | 0.0006415808 | 0.02547058360769006 / 0.007922064339996648 / 0.0028656541081260025 | 2.1400622545568232e-11 / 9.470548049612122e-08 / 4.4822333426382254e-07 | 0.012086101 | 3 |
| 72 | EVPL_1 | 0.0000007816 | 0.029829074750389078 / 0.0017371710506312126 / 0.008885340407261452 | 1.5237448098566468e-14 / 3.468917372397795e-07 / 8.845088917447386e-07 | 0.013483862 | 3 |
| 73 | ITPRIPL1_1 | 0.0000009682 | 0.008791850806005239 / 0.005999339290583331 / 0.02786434125186579 | 1.870754955730307e-08 / 2.8287486016651227e-07 / 2.360872288601893e-06 | 0.01421851 | 3 |
| 74 | MFSD5_3 | 0.0000006508 | 0.03071092956608319 / 0.003938218615229689 / 0.008114190972116433 | 1.5496424572725938e-08 / 3.2554288938109525e-07 / 1.0112718240540003e-07 | 0.014254446 | 3 |
| 75 | IL31RA_1 | 0.0002445888 | 0.02204380039340295 / 0.0012839803246042464 / 0.02580532183784653 | 3.674619339449928e-07 / 4.43344243632212e-07 / 1.71578946301816e-07 | 0.016377701 | 3 |
| 76 | PTP4A3_1 | 0.0000314449 | 0.020414472805311466 / 0.0014693336498995695 / 0.028891732420473607 | 4.776201023875552e-11 / 1.3766382593509082e-07 / 2.9989438068961905e-07 | 0.01692518 | 3 |
| 77 | MMP14_1 | 0.0002190770 | 0.04352684110019303 / 0.004148689189670186 / 0.007178678169977374 | 7.605828771352425e-12 / 1.360797271795892e-07 / 5.390408897387927e-06 | 0.018284736 | 3 |
| 78 | CAND2_3 | 0.0000026658 | 0.028895401482093127 / 0.0009805310391307427 / 0.027607746587453963 | 1.9907164721328134e-09 / 1.290177089971291e-07 / 1.422741749737834e-07 | 0.019161226 | 3 |
| 79 | ZNF292_5 | 0.0000000002 | 0.015104769480539766 / 0.026666883622270408 / 0.017197326894837075 | 4.1769031641265797e-11 / 1.3947688771774266e-09 / 6.03866098049317e-10 | 0.019656327 | 3 |
| 80 | EPSTI1_1 | 0.0000073158 | 0.021559234330291194 / 0.018300289055475042 / 0.02003497685558975 | 1.6504093087898275e-06 / 3.9975165582205597e-05 / 0.0030284224519400325 | 0.019964833 | 3 |
| 81 | CD97_5 | 0.0000002610 | 0.0038275409770200564 / 0.019102004865160463 / 0.037465966805106755 | 3.7683675686710715e-11 / 9.765240850418052e-10 / 9.834582681938526e-09 | 0.020131838 | 3 |
| 82 | POLE4_5 | 0.0000000093 | 0.043632422318038745 / 0.0070119701213412116 / 0.014099632537537078 | 8.269976083603455e-08 / 5.714696518125464e-08 / 1.8209465254324085e-07 | 0.021581342 | 3 |
| 83 | ZDHHC5_2 | 0.0009125715 | 0.029337781272574574 / 0.010806162088221837 / 0.028710223635555462 | 2.0943141147316446e-08 / 5.3448156529365833e-08 / 1.3376144680099656e-06 | 0.022951389 | 3 |
| 84 | CAV1_1 | 0.0000013507 | 0.026222968344836436 / 0.006833233979899956 / 0.03977242799449647 | 3.7284098504062e-09 / 1.981682163269309e-06 / 3.7034676836929953e-06 | 0.02427621 | 3 |
| 85 | PRDM15_1 | 0.0000000097 | 0.005780178191260254 / 0.0347977957945877 / 0.03765009109633616 | 4.1060665120296455e-08 / 1.8022427394306964e-06 / 1.2329107436658844e-06 | 0.026076022 | 3 |
| 86 | TXNL4A_1 | 0.0000015245 | 0.022383216654320942 / 0.019379827420147825 / 0.04981058007691468 | 1.0003973542061314e-07 / 8.318120908222264e-07 / 1.8197652803291898e-07 | 0.030524541 | 3 |
| 87 | PITX1_1 | 0.0000080593 | 0.022158530235155818 / 0.031511227848390264 / 0.04273165395476099 | 4.328726238704806e-08 / 4.785592074987919e-06 / 4.026072305691093e-05 | 0.032133804 | 3 |
| 88 | CDCA5_1 | 0.0000010967 | 0.00020876871631167866 / 1.4383640936438872e-05 | 3.9804264133636086e-05 / 7.242291833169782e-06 | 0.000111576 | 2 |
| 89 | S100A8_1 | 0.0000173360 | 0.00032665136423885464 / 0.001217467053354236 | 6.539606399624481e-07 / 3.473013871109409e-05 | 0.000772059 | 2 |
| 90 | ZNF345_2 | 0.0000000001 | 0.0027538076156700553 / 0.0004164659422400142 | 5.581451003007147e-05 / 2.582604692500973e-05 | 0.001585137 | 2 |
| 91 | CXXC1_2 | 0.0000000039 | 0.0037862695623801213 / 0.0005840830556010548 | 5.223754637766254e-09 / 5.323504510648734e-08 | 0.002185176 | 2 |
| 92 | ANO4_1 | 0.0000001136 | 0.004075435458657517 / 0.001327102464026624 | 3.235805354734205e-09 / 2.3414451573295386e-08 | 0.002701269 | 2 |
| 93 | STAG2_1 | 0.0000009873 | 0.0009656381268940972 / 0.004460012570027854 | 1.0115034206791287e-06 / 5.753841279635619e-06 | 0.002712825 | 2 |
| 94 | PBX4_1 | 0.0000007099 | 0.0037817634953029654 / 0.004617838797443333 | 2.7021040256543387e-08 / 9.484222614246193e-06 | 0.004199801 | 2 |
| 95 | RRM1_1 | 0.0000018281 | 0.00020876871631167866 / 0.010067369603256736 | 2.998747278117476e-12 / 3.3209239192147915e-07 | 0.005138069 | 2 |
| 96 | NUPL1_2 | 0.0000000000 | 0.00041289281227492434 / 0.011652453812603707 | 1.0657713091915916e-05 / 1.3751517277887033e-05 | 0.006032673 | 2 |
| 97 | MCFD2_2 | 0.0000002619 | 0.011150109007006106 / 0.0014577507615148278 | 2.5410316626468867e-07 / 2.943498549327363e-07 | 0.00630393 | 2 |
| 98 | IKBKAP_1 | 0.0000058887 | 0.012665982332335715 / 0.00011000641224999337 | 1.37456436935247e-06 / 3.934205458402021e-07 | 0.006387994 | 2 |
| 99 | KHK_2 | 0.0000008186 | 0.00035665903643679 / 0.014175997822512453 | 1.4320134905312087e-10 / 9.941441418824106e-06 | 0.007266328 | 2 |
| 100 | SEMA4B_1 | 0.0000003052 | 0.0015843420398457381 / 0.015326901145981139 | 1.468853625012769e-07 / 6.70265240601655e-08 | 0.008455622 | 2 |
| 101 | CEP41_1 | 0.0000001044 | 0.002099065390574213 / 0.015250218982745749 | 1.5608353601998867e-06 / 2.2562783101267498e-06 | 0.008674642 | 2 |
| 102 | DTX3L_1 | 0.0000012287 | 0.014588245785000514 / 0.004624429303044866 | 4.3810913690562183e-07 / 1.043509176420455e-05 | 0.009606338 | 2 |
| 103 | SMC2_1 | 0.0028804091 | 0.013707617481622131 / 0.006160764737320071 | 2.8848576349790795e-08 / 3.01310962529332e-06 | 0.009934191 | 2 |
| 104 | HDAC6_1 | 0.0009422566 | 0.010972403654712403 / 0.009810990348338811 | 1.4716710804724593e-08 / 1.7471497758357106e-07 | 0.010391697 | 2 |
| 105 | KDM3A_1 | 0.0000075561 | 0.006171913156047586 / 0.014901187095494001 | 9.834101497765351e-06 / 2.6427885077789545e-05 | 0.01053655 | 2 |
| 106 | DCAKD_1 | 0.0000000370 | 0.0018371780594793963 / 0.02029407943779478 | 2.2436458658220796e-06 / 3.459304592667202e-06 | 0.011065629 | 2 |
| 107 | DUSP5_1 | 0.0000000812 | 0.0018371780594793963 / 0.02029407943779478 | 8.010663169482405e-08 / 1.019028088460542e-05 | 0.011065629 | 2 |
| 108 | PRPF40A_2 | 0.0000001288 | 0.014088198537650237 / 0.008403090707899564 | 5.6662577214788655e-06 / 5.296682535807921e-06 | 0.011245645 | 2 |
| 109 | PPIB_4 | 0.0000014621 | 0.0009023360158888423 / 0.024925919514816482 | 4.368833166819811e-08 / 1.5361134806777145e-05 | 0.012914128 | 2 |
| 110 | ERAP2_2 | 0.0000000000 | 0.012146048132262622 / 0.016053861578409306 | 8.639554915354646e-08 / 3.070087173430692e-07 | 0.014099955 | 2 |
| 111 | BAALC_1 | 0.0000002690 | 0.01038558151359997 / 0.01797077169605779 | 1.6931423038276145e-08 / 1.1971112083511357e-08 | 0.014178177 | 2 |
| 112 | CACNA2D2_1 | 0.0000006401 | 0.01038558151359997 / 0.01797077169605779 | 3.602719217532972e-10 / 4.92697188032859e-10 | 0.014178177 | 2 |
| 113 | CNPY4_1 | 0.0000002878 | 0.013815890119720394 / 0.014734308310181646 | 1.4477884917386144e-08 / 1.2870154644475552e-06 | 0.014275099 | 2 |
| 114 | ANO5_1 | 0.0000004289 | 0.01945182673395856 / 0.010144750097293938 | 1.0116195313294412e-06 / 1.0659601228586417e-07 | 0.014798288 | 2 |
| 115 | KLK6_2 | 0.0000031514 | 0.010648596334043373 / 0.01921308313009029 | 6.133714219132002e-07 / 2.6008835809083705e-06 | 0.01493084 | 2 |
| 116 | TNIP2_1 | 0.0000070282 | 0.026512261541912406 / 0.0034616019934828575 | 1.2306882876630733e-08 / 9.976408891048964e-06 | 0.014986932 | 2 |
| 117 | KCNJ11_4 | 0.0000008906 | 0.000513024270655123 / 0.030480389193308928 | 9.976114533861802e-12 / 1.3939033644956155e-06 | 0.015496707 | 2 |
| 118 | MED14_1 | 0.0000001777 | 0.002121580446747506 / 0.02895588272033544 | 7.223100165739173e-08 / 5.7035521946275234e-06 | 0.015538732 | 2 |
| 119 | PDGFC_3 | 0.0000264872 | 0.019513649031375167 / 0.01309714342199912 | 6.270077252140188e-07 / 9.870611279741555e-05 | 0.016305396 | 2 |
| 120 | SLFN12_2 | 0.0000134765 | 0.02168635011054641 / 0.01167533043285143 | 1.966242069154016e-09 / 3.0933346339022715e-08 | 0.01668084 | 2 |
| 121 | PDP1_5 | 0.0000352407 | 0.026311459966079555 / 0.007838360079130574 | 4.024957504543219e-05 / 1.4145520941653468e-05 | 0.01707491 | 2 |
| 122 | IER5L_1 | 0.0000221943 | 0.02740923337273586 / 0.007187884748118219 | 4.3782241525162567e-08 / 1.83420306508174e-08 | 0.017298559 | 2 |
| 123 | ABCA5_2 | 0.0000000000 | 0.026787063397349216 / 0.00879535947608833 | 1.3685460854987295e-06 / 8.008743570631834e-06 | 0.017791211 | 2 |
| 124 | CABP7_1 | 0.0000019025 | 0.027796287019492286 / 0.008385988903950798 | 5.44509537364398e-08 / 4.285397797391745e-06 | 0.018091138 | 2 |
| 125 | FCRLB_5 | 0.0000000126 | 0.029561026010091924 / 0.009477250370701233 | 8.716818657445855e-09 / 3.812867727785123e-08 | 0.019519138 | 2 |
| 126 | TIGD3_1 | 0.0000185890 | 0.004581158169040506 / 0.0362634468993579 | 1.1724478296921851e-13 / 2.0363624639109813e-05 | 0.020422303 | 2 |
| 127 | ZNF295_1 | 0.0000305440 | 0.026753893459817307 / 0.01508657655367455 | 2.7477807935711586e-07 / 1.7656093493156047e-07 | 0.020920235 | 2 |
| 128 | PLD2_1 | 0.0000002785 | 0.027334357885610883 / 0.015006814582667545 | 6.430412303297122e-07 / 6.394643388050702e-07 | 0.021170586 | 2 |
| 129 | CD55_1 | 0.0000001511 | 0.0033161838556922097 / 0.04158968004878196 | 6.746452037536084e-10 / 2.2063569025007715e-08 | 0.022452932 | 2 |
| 130 | QKI_3 | 0.0000181952 | 0.005022174375240862 / 0.042671396636541896 | 3.032049011104229e-07 / 3.826421197615377e-07 | 0.023846786 | 2 |
| 131 | MZT1_1 | 0.0000022280 | 0.0014965558133177162 / 0.046327505690930644 | 5.073920441583328e-06 / 6.37180443076072e-06 | 0.023912031 | 2 |
| 132 | SEMA7A_1 | 0.0000140236 | 0.03342502222700243 / 0.015261311481267638 | 4.5276764265942424e-06 / 2.6190564781077353e-06 | 0.024343167 | 2 |
| 133 | ROR2_1 | 0.0000162778 | 0.02545372903328934 / 0.02593175339775004 | 5.907585641697503e-08 / 1.241188472253612e-06 | 0.025692741 | 2 |
| 134 | TRIP6_1 | 0.0000020904 | 0.038556379049173375 / 0.013202467191346512 | 2.7542851202738477e-08 / 5.023495130487458e-08 | 0.025879423 | 2 |
| 135 | C14orf142_1 | 0.0000007942 | 0.005868270029793827 / 0.046553563135817905 | 9.376272681986819e-08 / 4.128986695162416e-06 | 0.026210917 | 2 |
| 136 | ZEB1_2 | 0.0000468499 | 0.0213162921786289 / 0.0376737496455549 | 9.176186713429999e-08 / 2.4212534015690606e-05 | 0.029495021 | 2 |
| 137 | NIP7_2 | 0.0000000218 | 0.03316581736784557 / 0.0271384576648737 | 4.075740819100947e-06 / 5.399297858392524e-06 | 0.030152138 | 2 |
| 138 | GNAO1_1 | 0.0000005231 | 0.033760894472022615 / 0.026780216732580863 | 1.499270713634952e-09 / 1.217458355445439e-05 | 0.030270556 | 2 |
| 139 | FGF9_1 | 0.0000005137 | 0.03951670000167351 / 0.02495147370057548 | 2.989061419962864e-12 / 1.737392805769214e-09 | 0.032234087 | 2 |
| 140 | SERINC3_1 | 0.0000008268 | 0.026334033069056118 / 0.03845067832601619 | 9.100407986778662e-07 / 3.240588908989103e-07 | 0.032392356 | 2 |
| 141 | RSBN1_1 | 0.0000010033 | 0.026040435274654685 / 0.03886956807554024 | 2.221315610307105e-11 / 9.033061104976416e-08 | 0.032455002 | 2 |
| 142 | ARVCF_1 | 0.0000002829 | 0.026222968344836436 / 0.03977242799449647 | 7.483862897069276e-07 / 5.432934252510295e-07 | 0.032997698 | 2 |
| 143 | DTL_1 | 0.0000076383 | 0.039542232891747735 / 0.02707374976179199 | 3.398617522656201e-09 / 9.59460633791626e-07 | 0.033307991 | 2 |
| 144 | SRSF7_1 | 0.0000002874 | 0.0347977957945877 / 0.03765009109633616 | 6.847127318749837e-07 / 3.116230608631045e-07 | 0.036223943 | 2 |
| 145 | IFIT5_2 | 0.0004701599 | 0.0364953120948139 / 0.037232340056821626 | 4.399782821011542e-06 / 1.7393118846309304e-05 | 0.036863826 | 2 |
| 146 | NARF_1 | 0.0000022881 | 0.03953940913634625 / 0.03994379945480948 | 1.1301210005302875e-08 / 2.133257245226995e-06 | 0.039741604 | 2 |
| 147 | CASP8_1 | 0.0000198034 | 0.0464587665387115 / 0.0401631181784738 | 1.601941993185719e-16 / 2.6864531857041694e-11 | 0.043310942 | 2 |
| 148 | IL17RB_1 | 0.0000067045 | 0.04546047598682959 / 0.04334588252631349 | 3.033905276829337e-08 / 1.0262557517569413e-05 | 0.044403179 | 2 |
| 149 | SLC15A2_1 | 0.0000014155 | 5.681660863421172e-05 | 1.5961846511181405e-05 | 5.68166E-05 | 1 |
| 150 | SAR1B_1 | 0.0000005513 | 0.00013784539893700994 | 6.454907031718106e-06 | 0.000137845 | 1 |
| 151 | TTC1_1 | 0.0000004017 | 0.00013784539893700994 | 2.336682885494787e-10 | 0.000137845 | 1 |
| 152 | CRP_2 | 0.0000000078 | 0.00016321344400834376 | 5.576182275696905e-05 | 0.000163213 | 1 |
| 153 | GGCX_1 | 0.0000076825 | 0.00017247402077598097 | 1.2879118524126266e-07 | 0.000172474 | 1 |
| 154 | SOX9_1 | 0.0000013296 | 0.0001839790498817074 | 7.272296164227475e-06 | 0.000183979 | 1 |
| 155 | DLX5_3 | 0.0000326962 | 0.0003180382059133217 | 4.664951986768726e-07 | 0.000318038 | 1 |
| 156 | SNRNP25_3 | 0.0000000234 | 0.0003180382059133217 | 3.3152672324048814e-05 | 0.000318038 | 1 |
| 157 | UHRF1BP1L_1 | 0.0000001071 | 0.000349384308330678 | 2.1709474268278766e-06 | 0.000349384 | 1 |
| 158 | PAPD4_1 | 0.0000249556 | 0.0004361114375544852 | 1.8113390561602514e-06 | 0.000436111 | 1 |
| 159 | ADAMTS14_1 | 0.0000437150 | 0.0005765804746846872 | 6.590376972707598e-05 | 0.00057658 | 1 |
| 160 | FAT2_1 | 0.0000012964 | 0.0006381430782712855 | 4.603295730722451e-06 | 0.000638143 | 1 |
| 161 | ZNF750_2 | 0.0000000299 | 0.0007846622552824629 | 4.022726992390641e-05 | 0.000784662 | 1 |
| 162 | BTG2_1 | 0.0000093251 | 0.0008391695317782487 | 3.5774320349838873e-07 | 0.00083917 | 1 |
| 163 | PIGB_4 | 0.0000000787 | 0.0009023360158888423 | 2.2878500220993498e-11 | 0.000902336 | 1 |
| 164 | WHAMM_4 | 0.0000010450 | 0.0009023360158888423 | 1.1651758424474298e-06 | 0.000902336 | 1 |
| 165 | PELI2_2 | 0.0000000141 | 0.0012894304816227693 | 8.58480971255917e-08 | 0.00128943 | 1 |
| 166 | RPS5_1 | 0.0000036423 | 0.00134963344272631 | 2.405506994776735e-06 | 0.001349633 | 1 |
| 167 | DALRD3_1 | 0.0000008658 | 0.0013670815874214685 | 1.1128380015615429e-08 | 0.001367082 | 1 |
| 168 | ANKRD22_1 | 0.0000009306 | 0.0014573918997663137 | 3.138691465570034e-07 | 0.001457392 | 1 |
| 169 | AGBL4_5 | 0.0000001940 | 0.0014690065976330497 | 3.7344924411524894e-05 | 0.001469007 | 1 |
| 170 | DCUN1D2_1 | 0.0000001810 | 0.0014965558133177162 | 2.6955640062447783e-06 | 0.001496556 | 1 |
| 171 | RAP2A_1 | 0.0000043749 | 0.0014965558133177162 | 3.643928917883914e-07 | 0.001496556 | 1 |
| 172 | TEX30_1 | 0.0000077886 | 0.0014965558133177162 | 7.322882011832241e-07 | 0.001496556 | 1 |
| 173 | CPNE8_1 | 0.0000012221 | 0.0015823634728436365 | 1.0569424770637742e-11 | 0.001582363 | 1 |
| 174 | IFIT3_1 | 0.0000007653 | 0.0015904564617824036 | 2.30780238404599e-06 | 0.001590456 | 1 |
| 175 | KCNMB2_1 | 0.0000003403 | 0.0015904564617824036 | 1.6585833620905925e-08 | 0.001590456 | 1 |
| 176 | TRIM21_1 | 0.0000000854 | 0.0015904564617824036 | 2.1285881318643393e-08 | 0.001590456 | 1 |
| 177 | NAP1L4_1 | 0.0000087541 | 0.0017153185879343034 | 7.850131843413566e-06 | 0.001715319 | 1 |
| 178 | GALNT3_1 | 0.0000354752 | 0.0020476470911988563 | 2.5573822901107337e-05 | 0.002047647 | 1 |
| 179 | EVL_1 | 0.0000019885 | 0.002058130936511972 | 2.717135803874761e-09 | 0.002058131 | 1 |
| 180 | TSPAN8_1 | 0.0000003090 | 0.0021489267613823003 | 1.017187347139058e-05 | 0.002148927 | 1 |
| 181 | RUNDC3B_1 | 0.0000041888 | 0.0024846662085153902 | 1.016379726019311e-05 | 0.002484666 | 1 |
| 182 | CCDC113_1 | 0.0000076744 | 0.0025150135152389474 | 1.5032272736368673e-06 | 0.002515014 | 1 |
| 183 | PIAS2_2 | 0.0000001786 | 0.0025152679462084955 | 2.2483779303553648e-06 | 0.002515268 | 1 |
| 184 | ALG14_1 | 0.0000072016 | 0.0026041641330007506 | 0.0006233183228222267 | 0.002604164 | 1 |
| 185 | TAF11_1 | 0.0000009139 | 0.002687295907204792 | 0.00012476609977995568 | 0.002687296 | 1 |
| 186 | KCNK9_1 | 0.0011919577 | 0.0028046841261304568 | 1.376632392689302e-07 | 0.002804684 | 1 |
| 187 | LRRC8A_1 | 0.0000035240 | 0.0032327742303384166 | 6.356756636137029e-06 | 0.003232774 | 1 |
| 188 | TMEM151B_1 | 0.0000007358 | 0.0032636781607269594 | 1.8328686422960692e-06 | 0.003263678 | 1 |
| 189 | C10orf76_1 | 0.0000881113 | 0.003434642569271992 | 7.673926087001424e-06 | 0.003434643 | 1 |
| 190 | NXNL2_1 | 0.0000597168 | 0.003544372498506248 | 3.942459986260573e-08 | 0.003544372 | 1 |
| 191 | TCEB3_1 | 0.0005226535 | 0.0037150885246972363 | 0.00024989766039529933 | 0.003715089 | 1 |
| 192 | CPEB2_2 | 0.0000010060 | 0.003774743841069769 | 2.850551586644877e-06 | 0.003774744 | 1 |
| 193 | TUBB_1 | 0.0000000607 | 0.0037817634953029654 | 8.334855345042203e-07 | 0.003781763 | 1 |
| 194 | UBE2H_1 | 0.0000005261 | 0.004043548766154216 | 2.7343581965712453e-07 | 0.004043549 | 1 |
| 195 | TM9SF4_1 | 0.0000000634 | 0.004075435458657517 | 1.208568331650002e-06 | 0.004075435 | 1 |
| 196 | ZNF250_1 | 0.0001614132 | 0.004581158169040506 | 8.906742496574832e-08 | 0.004581158 | 1 |
| 197 | ARSD_1 | 0.0000007813 | 0.004617838797443333 | 4.0431258909202725e-06 | 0.004617839 | 1 |
| 198 | ZBED5_5 | 0.0000000106 | 0.005222164163583828 | 1.6160725995889468e-06 | 0.005222164 | 1 |
| 199 | TEAD3_3 | 0.0000036458 | 0.0053872635110084445 | 4.1927795302166964e-05 | 0.005387264 | 1 |
| 200 | PAICS_1 | 0.0023017121 | 0.005473511421368178 | 0.001803574650219185 | 0.005473511 | 1 |
| 201 | SDSL_1 | 0.0000016496 | 0.006403254151390212 | 7.017651789933182e-08 | 0.006403254 | 1 |
| 202 | SP140L_1 | 0.0000004574 | 0.00690906973800756 | 1.4293392545039821e-08 | 0.00690907 | 1 |
| 203 | VEZF1_1 | 0.0000006200 | 0.007512524281614588 | 4.015799360215652e-07 | 0.007512524 | 1 |
| 204 | TSR2_2 | 0.0000001115 | 0.00807009151771129 | 5.455073735317627e-08 | 0.008070092 | 1 |
| 205 | LRFN5_1 | 0.0001487507 | 0.00837748774812484 | 1.765094200227484e-07 | 0.008377488 | 1 |
| 206 | HMOX1_3 | 0.0000000049 | 0.009019901589667713 | 3.3116226812292643e-07 | 0.009019902 | 1 |
| 207 | OAF_2 | 0.0000021448 | 0.010087189185487436 | 6.611044842333954e-06 | 0.010087189 | 1 |
| 208 | C1orf198_1 | 0.0047644878 | 0.01058743988900243 | 5.33047484084318e-06 | 0.01058744 | 1 |
| 209 | RNF145_1 | 0.0000015182 | 0.010685297092225236 | 3.4948918270211384e-09 | 0.010685297 | 1 |
| 210 | TFDP1_2 | 0.0000000087 | 0.011664876607743443 | 1.0484496266632918e-06 | 0.011664877 | 1 |
| 211 | TRIM33_5 | 0.0000006448 | 0.012312852331877405 | 5.823849535285043e-07 | 0.012312852 | 1 |
| 212 | BRD1_1 | 0.0000056060 | 0.012444591121133452 | 9.00450493226787e-08 | 0.012444591 | 1 |
| 213 | RAB18_1 | 0.0000000557 | 0.012469136109983507 | 7.808669892591835e-06 | 0.012469136 | 1 |
| 214 | DOK6_1 | 0.0000225131 | 0.0126479390211753 | 2.9116700927572027e-07 | 0.012647939 | 1 |
| 215 | TMEM132D_1 | 0.0000007064 | 0.014125552794811447 | 0.00013933215110235875 | 0.014125553 | 1 |
| 216 | RBKS_1 | 0.0000039408 | 0.014510361909036783 | 1.369930658748886e-10 | 0.014510362 | 1 |
| 217 | SDPR_1 | 0.0000144016 | 0.015098577756027905 | 1.2200927403044487e-06 | 0.015098578 | 1 |
| 218 | HADHB_3 | 0.0000011607 | 0.015198702702676786 | 4.67481146425626e-06 | 0.015198703 | 1 |
| 219 | RAB2B_1 | 0.0000015355 | 0.015525342789786052 | 9.240171811293034e-08 | 0.015525343 | 1 |
| 220 | CLSPN_2 | 0.0015604856 | 0.015681284994245294 | 4.787605013931291e-06 | 0.015681285 | 1 |
| 221 | LRCH2_1 | 0.0000013499 | 0.016913586137948928 | 3.239478361523596e-06 | 0.016913586 | 1 |
| 222 | RIC8B_1 | 0.0000258855 | 0.018613210669019453 | 2.5972193291243487e-07 | 0.018613211 | 1 |
| 223 | SNX17_1 | 0.0000005150 | 0.0187791714585435 | 7.832292477544212e-06 | 0.018779171 | 1 |
| 224 | HPS1_3 | 0.0000193423 | 0.020032646836294014 | 2.651724363437782e-08 | 0.020032647 | 1 |
| 225 | TNNT3_1 | 0.0000037981 | 0.02003497685558975 | 0.0024373027878036467 | 0.020034977 | 1 |
| 226 | MPHOSPH9_1 | 0.0000010033 | 0.020273128817757814 | 5.7180542135867475e-06 | 0.020273129 | 1 |
| 227 | PCDH7_1 | 0.0000026780 | 0.020321552294661337 | 1.8717328001192637e-06 | 0.020321552 | 1 |
| 228 | NSL1_1 | 0.0000025413 | 0.020596934169840004 | 1.6439984899784691e-06 | 0.020596934 | 1 |
| 229 | ALG9_1 | 0.0001111425 | 0.022935884489828733 | 1.7377644622722088e-06 | 0.022935884 | 1 |
| 230 | PDE12_1 | 0.0000004658 | 0.0233155726865293 | 1.5807742224423866e-05 | 0.023315573 | 1 |
| 231 | PAPSS2_1 | 0.0000007706 | 0.024338654294994898 | 9.283888609188878e-08 | 0.024338654 | 1 |
| 232 | ZFHX2_1 | 0.0000004187 | 0.02464096203134193 | 2.8806779697573074e-06 | 0.024640962 | 1 |
| 233 | TFG_2 | 0.0000000179 | 0.02485916255363959 | 5.4417829495431724e-05 | 0.024859163 | 1 |
| 234 | IL15RA_1 | 0.0000004083 | 0.02498090614719385 | 2.4652810837821435e-06 | 0.024980906 | 1 |
| 235 | MBTD1_1 | 0.0000000005 | 0.02498090614719385 | 2.476481267971609e-05 | 0.024980906 | 1 |
| 236 | TMPRSS4_1 | 0.0001737302 | 0.02527275878591322 | 4.96032498878352e-07 | 0.025272759 | 1 |
| 237 | APBB1_1 | 0.0007952642 | 0.025477899370092264 | 1.1177566606698288e-07 | 0.025477899 | 1 |
| 238 | MAD2L2_1 | 0.0000650171 | 0.025477899370092264 | 7.015450869623152e-07 | 0.025477899 | 1 |
| 239 | MAP4_1 | 0.0000021567 | 0.026512261541912406 | 5.151370139997939e-07 | 0.026512262 | 1 |
| 240 | GLTP_1 | 0.0000002645 | 0.02685009566751369 | 1.2940153369292968e-05 | 0.026850096 | 1 |
| 241 | CECR2_1 | 0.0000034126 | 0.02695039496870006 | 4.8390480434201144e-06 | 0.026950395 | 1 |
| 242 | RUFY1_1 | 0.0000299227 | 0.027256120811697704 | 8.232591388149916e-11 | 0.027256121 | 1 |
| 243 | LRRN1_3 | 0.0000000006 | 0.027852483618169322 | 2.4617114447232193e-06 | 0.027852484 | 1 |
| 244 | ATRIP_1 | 0.0000459410 | 0.028297897669394324 | 3.581872487568641e-06 | 0.028297898 | 1 |
| 245 | NADKD1_1 | 0.0001614851 | 0.030463092594199083 | 9.476649004029163e-08 | 0.030463093 | 1 |
| 246 | DAPL1_5 | 0.0000001131 | 0.03247309026025267 | 1.063046591606967e-06 | 0.03247309 | 1 |
| 247 | HSD17B10_1 | 0.0000356915 | 0.03300637436842342 | 3.315891641410488e-08 | 0.033006374 | 1 |
| 248 | CTSL1_5 | 0.0000012024 | 0.033080135108199266 | 2.1760418610560375e-10 | 0.033080135 | 1 |
| 249 | PPM1F_2 | 0.0000003736 | 0.033564554983805193 | 6.023420324819565e-06 | 0.033564555 | 1 |
| 250 | SERPINB8_1 | 0.0000004020 | 0.03395639101055327 | 7.590142415124812e-06 | 0.033956391 | 1 |
| 251 | LEPREL4_1 | 0.0000031108 | 0.03517044127467462 | 9.048855093781964e-06 | 0.035170441 | 1 |
| 252 | HIRA_1 | 0.0000071773 | 0.036656389092885745 | 6.41338762201109e-06 | 0.036656389 | 1 |
| 253 | MET_2 | 0.0000048647 | 0.03675726542857143 | 4.0499324464518144e-07 | 0.036757265 | 1 |
| 254 | ST18_2 | 0.0000003070 | 0.03675726542857143 | 2.1367286772341655e-08 | 0.036757265 | 1 |
| 255 | IFI35_1 | 0.0000001142 | 0.037485659344956734 | 1.8673858169252516e-08 | 0.037485659 | 1 |
| 256 | CNKSR3_1 | 0.0000002224 | 0.0380562899913768 | 1.4065162180136549e-05 | 0.03805629 | 1 |
| 257 | NFKBIZ_1 | 0.0002437797 | 0.038514781543232596 | 2.106101897324396e-07 | 0.038514782 | 1 |
| 258 | TFPI_1 | 0.0050804078 | 0.038514781543232596 | 7.186644444797165e-08 | 0.038514782 | 1 |
| 259 | PDIA6_1 | 0.0000012653 | 0.038781900239634945 | 1.1794828467593882e-06 | 0.0387819 | 1 |
| 260 | RSF1_3 | 0.0000000002 | 0.03932106882555421 | 1.1649216389446077e-06 | 0.039321069 | 1 |
| 261 | MYO1E_2 | 0.0000209873 | 0.039881619914679374 | 4.562099888852519e-11 | 0.03988162 | 1 |
| 262 | UBAP1_1 | 0.0000010913 | 0.040258840897526606 | 2.649945837106964e-07 | 0.040258841 | 1 |
| 263 | GFER_1 | 0.0000199213 | 0.041058990270996985 | 1.013140578199153e-06 | 0.04105899 | 1 |
| 264 | C17orf75_1 | 0.0000001475 | 0.041863358380761856 | 2.011957469008045e-05 | 0.041863358 | 1 |
| 265 | TTC9B_1 | 0.0000199304 | 0.0440605439544666 | 1.3515245965925785e-06 | 0.044060544 | 1 |
| 266 | FAM198B_1 | 0.0000000398 | 0.04544630802892216 | 1.2975083762851168e-06 | 0.045446308 | 1 |
| 267 | DCTD_1 | 0.0000002300 | 0.045495607074215974 | 9.613702843960257e-08 | 0.045495607 | 1 |
| 268 | ZSCAN16_1 | 0.0000002003 | 0.04907931555044797 | 6.364155025566868e-08 | 0.049079316 | 1 |
| 269 | CCDC14_2 | 0.0000000040 | 0.049412789880137475 | 1.0956612304568067e-06 | 0.04941279 | 1 |
| 270 | TRIP11_1 | 0.0000106522 | 0.049477459520320635 | 3.616757502303368e-08 | 0.04947746 | 1 |
| 271 | NKAIN2_1 | 0.0000341788 | 0.04968678580260802 | 1.3235403934017564e-06 | 0.049686786 | 1 |
| 272 | NT5E_1 | 0.0000065065 | 0.04968678580260802 | 1.050035169104463e-10 | 0.049686786 | 1 |
| 273 | PPP1R14A_5 | 0.0000105571 | 0.00022092891960888485 | 5.27242603779648e-05 | 0.000220929 | 1 |
| 274 | CDH2_1 | 0.0001087650 | 0.0005511270416472728 | 0.0004028031199308745 | 0.000551127 | 1 |
| 275 | EMC3_1 | 0.0000000114 | 0.0006784104611363802 | 3.0652280007137936e-05 | 0.00067841 | 1 |
| 276 | NCAPG2_1 | 0.0000228504 | 0.0007900043500214932 | 0.0004768223953633258 | 0.000790004 | 1 |
| 277 | OR13H1_2 | 0.0011906247 | 0.024195410263062368 | 0.024770686509726116 | 0.02419541 | 1 |
[표 12]에는 육종암(bone) 약물에 연관된 FRH 들과, 이와 연관된 육종암 약물들 및 FRH를 정의하는 마커들이 정리되어 있다.
또한, [표 13] 에는 [표 12]에 제시된 FRH들의 반응성(P-value) 정도를 산출한 결과가 정리되어 있다.
이들 표에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(Pvlaue)값을 의미하는 것으로, [표 12]에 정리된 약물의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Exp_Drug(pval)』해당 유전자 발현이 약물 반응성이 미치는 상관도(Pvlaue)값이 [표 12]에 정리된 약물의 순서에 따라 정리되어 있고, 『Ave_VarDrug(pval)』는 『Var_Drug(pval)』산출값들의 평균값을 의미하며, 『Rank』는 해당 FRH가 유의성 있게 영향을 미치는 육종암 약물의 수를 의미한다.
이들 반응성 검증결과로부터, Var_Exp(pval)이 낮을수록, Var_Drug(pval) 및 이의 평균값인 Ave_VarDrug(pval)이 낮을수록, Exp_Drug(pval)이 낮을수록, Rank 수가 높을수록 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 35에는 표 12에 기재된 바이오마커들 중 주요 바이오마커들의 육종암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있고, 도 36에는 주요 바이오마커들에 의해 발현된 유전자들과 육종암 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Drug | DrugType | Var(마커) |
| 1 | LUC7L_5 | 263_FR-180204 / 310_YM201636 / 294_MPS-1-IN-1 / 228_KIN001-102 / 326_GSK690693 / 288_KIN001-055 / 303_PIK-93 / 1498_AZD6244 / 305_TPCA-1 / 271_VNLG/124 / 245_UNC0638 / 330_XMD13-2 / 282_EKB-569 / 1526_RDEA119 (rescreen) / 286_KIN001-236 / 344_THZ-2-49 / 256_JW-7-24-1 / 185_OSI-906 / 304_SB52334 / 265_Tubastatin A / 283_GSK2126458 / 253_XMD14-99 / 346_THZ-2-102-1 / 298_OSI-930 / 257_NPK76-II-72-1 / 1372_Trametinib / 331_QL-X-138 / 1014_RDEA119 / 290_KIN001-260 / 221_TAK-715 / 252_WZ3105 / 276_CAY10603 / 287_KIN001-244 / 306_TG101348 / 179_5-Fluorouracil / 301_PHA-793887 / 273_CUDC-101 / 291_KIN001-266 / 300_CX-5461 / 226_GSK1070916 / 1010_Gefitinib / 281_CH5424802 / 1242_(5Z)-7-Oxozeaenol / 223_ZSTK474 / 1011_ABT-263 / 292_Masitinib / 1008_Methotrexate / 175_PAC-1 / 299_OSI-027 / 238_CAL-101 / 275_I-BET-762 / 225_Genentech Cpd 10 / 328_SNX-2112 / 254_AC220 / 211_TL-2-105 / 274_Belinostat / 260_NG-25 / 279_BIX02189 / 152_CP466722 / 272_AR-42 / 136_Mitomycin C / 222_BX-912 / 208_SB-715992 / 184_BMS-754807 / 56_WH-4-023 / 1218_JQ1 / 1091_BMS-536924 / 1017_Olaparib / 341_EX-527 / 261_TL-1-85 / 1259_BMN-673 / 1060_PD-0325901 / 205_BMS-708163 / 196_Phenformin / 302_PI-103 / 309_Y-39983 / 1020_Lenalidomide / 1005_Cisplatin / 1262_UNC1215 / 329_QL-XI-92 / 1495_Olaparib / 295_NVP-BHG712 / 258_STF-62247 / 200_LAQ824 / 1026_17-AAG / 1039_SL 0101-1 / 255_CP724714 / 219_AT-7519 / 308_XL-880 / 1248_FK866 / 224_AS605240 / 235_QL-XII-47 / 203_BMS-345541 / 182_Obatoclax Mesylate / 1012_Vorinostat / 1013_Nilotinib / 1175_AG-014699 / 135_Gemcitabine / 266_Zibotentan / 178_BAY 61-3606 / 332_XMD15-27 / 1264_SGC0946 / 1166_QL-VIII-58 / 1018_ABT-888 / 1069_EHT 1864 | erk_mapk / other / mitosis / pi3k / pi3k / other / pi3k / erk_mapk / other / chromatin / chromatin / other / egfr / erk_mapk / other / cell_cyc / other / igfr / rtk / chromatin / pi3k / rtk / cell_cyc / rtk / mitosis / erk_mapk / other / erk_mapk / other / jnk_p38 / other / chromatin / pi3k / other / DNArep / cell_cyc / chromatin / other / other / mitosis / egfr / rtk / other / pi3k / apop / rtk / DNArep / apop / tor / pi3k / chromatin / mitosis / other / rtk / erk_mapk / chromatin / other / other / g_integrity / chromatin / DNArep / pi3k / mitosis / igfr / abl / chromatin / igfr / g_integrity / other / other / g_integrity / erk_mapk / other / metabol / pi3k / cytoskeleton / other / DNArep / other / rtk / g_integrity / rtk / other / chromatin / other / erk_mapk / egfr / cell_cyc / rtk / metabol / pi3k / other / other / apop / chromatin / abl / g_integrity / DNArep / other / other / other / chromatin / tor / g_integrity / cytoskeleton | 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 5_141432375_A_C / 22_18847351_G_C |
| 2 | FZD3_1 | 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 223_ZSTK474_2 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 304_SB52334_3 / 224_AS605240_3 / 282_Pelitinib_2 / 253_XMD14-99_3 / 263_FR-180204_3 / 326_GSK690693_3 / 152_CP466722_3 / 225_Genentech Cpd 10_3 / 290_KIN001-260_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 286_KIN001-236_3 / 238_Idelalisib_1 / 299_OSI-027_2 / 272_AR-42_2 / 298_OSI-930_2 / 222_BX-912_3 / 265_Tubastatin A_3 / 275_I-BET-762_3 / 306_Fedratinib_2 / 276_CAY10603_3 / 208_Ispinesib Mesylate_2 / 203_BMS-345541_3 / 256_JW-7-24-1_3 / 274_Belinostat_1 / 301_PHA-793887_3 / 219_AT-7519_2 / 303_PIK-93_3 / 252_WZ3105_3 / 329_QL-XI-92_3 / 257_NPK76-II-72-1_3 / 273_CUDC-101_2 / 1091_BMS-536924_3 / 288_WHI-P97_3 / 261_TL-1-85_3 / 211_TL-2-105_3 / 271_VNLG/124_3 | pi3k / mitosis / pi3k / pi3k / other / mitosis / other / rtk / rtk / pi3k / egfr / rtk / erk_mapk / pi3k / g_integrity / mitosis / other / other / jnk_p38 / other / pi3k / tor / chromatin / rtk / pi3k / chromatin / chromatin / other / chromatin / mitosis / other / other / chromatin / cell_cyc / cell_cyc / pi3k / other / rtk / mitosis / chromatin / igfr / other / other / erk_mapk / chromatin | 1_26457907_T_G |
| 3 | LMBR1L_3 | 261_TL-1-85_3 / 281_Alectinib_2 / 291_KIN001-266_3 / 346_THZ-2-102-1_3 / 310_YM201636_3 / 257_NPK76-II-72-1_3 / 344_THZ-2-49_3 / 303_PIK-93_3 / 286_KIN001-236_3 / 256_JW-7-24-1_3 / 328_SNX-2112_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 287_KIN001-244_3 / 294_MPS-1-IN-1_3 / 260_NG-25_3 / 290_KIN001-260_3 / 345_KIN001-270_3 / 208_Ispinesib Mesylate_2 / 301_PHA-793887_3 / 305_TPCA-1_3 / 331_QL-X-138_3 / 225_Genentech Cpd 10_3 / 299_OSI-027_2 / 273_CUDC-101_2 / 276_CAY10603_3 / 226_GSK1070916_2 / 265_Tubastatin A_3 / 292_Masitinib_1 / 263_FR-180204_3 / 272_AR-42_2 / 152_CP466722_3 / 326_GSK690693_3 / 283_Omipalisib_2 | other / rtk / other / cell_cyc / other / mitosis / cell_cyc / pi3k / other / other / other / other / other / pi3k / mitosis / other / other / cell_cyc / mitosis / cell_cyc / other / other / mitosis / tor / chromatin / chromatin / mitosis / chromatin / rtk / erk_mapk / chromatin / g_integrity / pi3k / pi3k | 20_35697711_A_C / 7_72949311_A_C / 12_109266204_T_G |
| 4 | ACTN2_3 | 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 328_SNX-2112_3 / 344_THZ-2-49_3 / 290_KIN001-260_3 / 287_KIN001-244_3 / 304_SB52334_3 / 330_XMD13-2_3 / 256_JW-7-24-1_3 / 245_UNC0638_3 / 252_WZ3105_3 / 299_OSI-027_2 / 257_NPK76-II-72-1_3 / 286_KIN001-236_3 / 152_CP466722_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 346_THZ-2-102-1_3 / 179_5-Fluorouracil_1 / 260_NG-25_3 / 253_XMD14-99_3 / 226_GSK1070916_2 / 331_QL-X-138_3 / 261_TL-1-85_3 / 279_BIX02189_3 / 223_ZSTK474_2 / 291_KIN001-266_3 / 271_VNLG/124_3 | other / erk_mapk / mitosis / other / pi3k / pi3k / other / other / cell_cyc / other / pi3k / rtk / other / other / chromatin / other / tor / mitosis / other / g_integrity / pi3k / pi3k / cell_cyc / DNArep / other / rtk / mitosis / other / other / other / pi3k / other / chromatin | 1_26457907_T_G / 22_18847351_G_C / 22_21127217_C_G |
| 5 | UBXN7_2 | 310_YM201636_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 / 256_JW-7-24-1_3 / 265_Tubastatin A_3 / 226_GSK1070916_2 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 271_VNLG/124_3 / 301_PHA-793887_3 / 185_Linsitinib_2 / 1017_Olaparib_2 / 253_XMD14-99_3 / 136_Mitomycin-C_1 / 1495_Olaparib_1 / 281_Alectinib_2 / 257_NPK76-II-72-1_3 / 292_Masitinib_1 / 1003_Camptothecin_1 / 290_KIN001-260_3 / 298_OSI-930_2 / 283_Omipalisib_2 / 300_CX-5461_3 / 304_SB52334_3 / 273_CUDC-101_2 / 223_ZSTK474_2 / 299_OSI-027_2 / 331_QL-X-138_3 | other / g_integrity / cell_cyc / other / other / mitosis / pi3k / erk_mapk / other / chromatin / mitosis / other / pi3k / chromatin / cell_cyc / igfr / g_integrity / rtk / DNArep / g_integrity / rtk / mitosis / rtk / DNArep / other / rtk / pi3k / other / rtk / chromatin / pi3k / tor / other | 22_24252424_G_C / 1_26457907_T_G |
| 6 | TRAM2_2 | 226_GSK1070916_2 / 310_YM201636_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 305_TPCA-1_3 / 299_OSI-027_2 / 228_AKT_inhibitor_VIII_3 / 256_JW-7-24-1_3 / 221_TAK-715_2 / 252_WZ3105_3 / 346_THZ-2-102-1_3 / 301_PHA-793887_3 / 222_BX-912_3 / 1259_Talazoparib_3 / 257_NPK76-II-72-1_3 / 283_Omipalisib_2 / 208_Ispinesib Mesylate_2 / 253_XMD14-99_3 / 303_PIK-93_3 / 326_GSK690693_3 / 344_THZ-2-49_3 / 304_SB52334_3 / 302_PI-103_3 / 286_KIN001-236_3 / 287_KIN001-244_3 / 223_ZSTK474_2 / 225_Genentech Cpd 10_3 / 254_Quizartinib_2 / 265_Tubastatin A_3 / 331_QL-X-138_3 | mitosis / other / erk_mapk / other / mitosis / other / other / tor / pi3k / other / jnk_p38 / other / cell_cyc / cell_cyc / pi3k / g_integrity / mitosis / pi3k / mitosis / rtk / pi3k / pi3k / cell_cyc / rtk / pi3k / other / pi3k / pi3k / mitosis / rtk / chromatin / other | 1_26457907_T_G / 22_21127217_C_G |
| 7 | CDK13_2 | 326_GSK690693_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 301_PHA-793887_3 / 331_QL-X-138_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 306_Fedratinib_2 / 275_I-BET-762_3 / 295_NVP-BHG712_3 / 279_BIX02189_3 / 256_JW-7-24-1_3 / 346_THZ-2-102-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 226_GSK1070916_2 / 286_KIN001-236_3 / 290_KIN001-260_3 / 257_NPK76-II-72-1_3 / 299_OSI-027_2 / 282_Pelitinib_2 / 223_ZSTK474_2 / 245_UNC0638_3 / 304_SB52334_3 / 302_PI-103_3 / 253_XMD14-99_3 / 328_SNX-2112_3 / 238_Idelalisib_1 | pi3k / other / cell_cyc / other / pi3k / erk_mapk / cell_cyc / other / pi3k / mitosis / other / other / chromatin / rtk / other / other / cell_cyc / other / pi3k / mitosis / other / other / mitosis / tor / egfr / pi3k / chromatin / rtk / pi3k / rtk / other / pi3k | 1_26457907_T_G / 22_30937565_T_G |
| 8 | BCL11B_3 | 310_YM201636_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 263_FR-180204_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 256_JW-7-24-1_3 / 226_GSK1070916_2 / 288_WHI-P97_3 / 257_NPK76-II-72-1_3 / 303_PIK-93_3 / 290_KIN001-260_3 / 299_OSI-027_2 / 276_CAY10603_3 / 245_UNC0638_3 / 326_GSK690693_3 / 152_CP466722_3 / 283_Omipalisib_2 / 273_CUDC-101_2 / 346_THZ-2-102-1_3 / 223_ZSTK474_2 / 274_Belinostat_1 / 304_SB52334_3 / 279_BIX02189_3 / 1259_Talazoparib_3 / 272_AR-42_2 / 286_KIN001-236_3 / 287_KIN001-244_3 | other / cell_cyc / other / erk_mapk / other / pi3k / other / mitosis / rtk / other / mitosis / other / mitosis / pi3k / other / tor / chromatin / chromatin / pi3k / g_integrity / pi3k / chromatin / cell_cyc / pi3k / chromatin / rtk / other / g_integrity / chromatin / other / pi3k | 1_26457907_T_G / 5_141432375_A_C / 22_22643666_C_G |
| 9 | LONRF1_4 | 344_THZ-2-49_3 / 288_WHI-P97_3 / 263_FR-180204_3 / 310_YM201636_3 / 330_XMD13-2_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 252_WZ3105_3 / 256_JW-7-24-1_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 299_OSI-027_2 / 303_PIK-93_3 / 291_KIN001-266_3 / 279_BIX02189_3 / 346_THZ-2-102-1_3 / 276_CAY10603_3 / 226_GSK1070916_2 / 292_Masitinib_1 / 265_Tubastatin A_3 / 273_CUDC-101_2 / 245_UNC0638_3 / 287_KIN001-244_3 / 152_CP466722_3 / 261_TL-1-85_3 / 208_Ispinesib Mesylate_2 / 1259_Talazoparib_3 | cell_cyc / other / erk_mapk / other / other / mitosis / mitosis / other / other / other / other / other / pi3k / tor / pi3k / other / other / cell_cyc / chromatin / mitosis / rtk / chromatin / chromatin / chromatin / pi3k / g_integrity / other / mitosis / g_integrity | 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 15_42142087_A_C |
| 10 | NUDT16_1 | 344_THZ-2-49_3 / 330_XMD13-2_3 / 310_YM201636_3 / 273_CUDC-101_2 / 226_GSK1070916_2 / 272_AR-42_2 / 276_CAY10603_3 / 263_FR-180204_3 / 326_GSK690693_3 / 274_Belinostat_1 / 252_WZ3105_3 / 253_XMD14-99_3 / 265_Tubastatin A_3 / 256_JW-7-24-1_3 / 208_Ispinesib Mesylate_2 / 283_Omipalisib_2 / 228_AKT_inhibitor_VIII_3 / 301_PHA-793887_3 / 225_Genentech Cpd 10_3 / 281_Alectinib_2 / 294_MPS-1-IN-1_3 / 299_OSI-027_2 / 1259_Talazoparib_3 / 292_Masitinib_1 / 305_TPCA-1_3 / 298_OSI-930_2 / 290_KIN001-260_3 / 286_KIN001-236_3 / 257_NPK76-II-72-1_3 | cell_cyc / other / other / chromatin / mitosis / chromatin / chromatin / erk_mapk / pi3k / chromatin / other / rtk / chromatin / other / mitosis / pi3k / pi3k / cell_cyc / mitosis / rtk / mitosis / tor / g_integrity / rtk / other / rtk / other / other / mitosis | 1_26457907_T_G |
| 11 | BDKRB1_1 | 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 290_KIN001-260_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 330_XMD13-2_3 / 136_Mitomycin-C_1 / 305_TPCA-1_3 / 300_CX-5461_3 / 283_Omipalisib_2 / 254_Quizartinib_2 / 221_TAK-715_2 / 226_GSK1070916_2 / 252_WZ3105_3 / 303_PIK-93_3 / 301_PHA-793887_3 / 346_THZ-2-102-1_3 / 1008_Methotrexate_1 / 304_SB52334_3 / 253_XMD14-99_3 / 257_NPK76-II-72-1_3 / 1142_HG-5-113-01_2 / 326_GSK690693_3 / 281_Alectinib_2 / 299_OSI-027_2 / 286_KIN001-236_3 | other / mitosis / erk_mapk / other / pi3k / g_integrity / cell_cyc / other / DNArep / other / other / pi3k / rtk / jnk_p38 / mitosis / other / pi3k / cell_cyc / cell_cyc / DNArep / rtk / rtk / mitosis / abl / pi3k / rtk / tor / other | 22_22643666_C_G |
| 12 | ACVR1B_1 | 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 304_SB52334_3 / 310_YM201636_3 / 290_KIN001-260_3 / 303_PIK-93_3 / 265_Tubastatin A_3 / 276_CAY10603_3 / 225_Genentech Cpd 10_3 / 272_AR-42_2 / 228_AKT_inhibitor_VIII_3 / 274_Belinostat_1 / 253_XMD14-99_3 / 226_GSK1070916_2 / 283_Omipalisib_2 / 185_Linsitinib_2 / 257_NPK76-II-72-1_3 / 223_ZSTK474_2 / 299_OSI-027_2 / 256_JW-7-24-1_3 / 281_Alectinib_2 / 273_CUDC-101_2 / 326_GSK690693_3 / 330_XMD13-2_3 / 291_KIN001-266_3 / 152_CP466722_3 / 263_FR-180204_3 | mitosis / other / rtk / other / other / pi3k / chromatin / chromatin / mitosis / chromatin / pi3k / chromatin / rtk / mitosis / pi3k / igfr / mitosis / pi3k / tor / other / rtk / chromatin / pi3k / other / other / g_integrity / erk_mapk | 1_26457907_T_G |
| 13 | FUCA2_5 | 310_YM201636_3 / 344_THZ-2-49_3 / 245_UNC0638_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 273_CUDC-101_2 / 288_WHI-P97_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 265_Tubastatin A_3 / 256_JW-7-24-1_3 / 253_XMD14-99_3 / 304_SB52334_3 / 326_GSK690693_3 / 276_CAY10603_3 / 226_GSK1070916_2 / 271_VNLG/124_3 / 346_THZ-2-102-1_3 / 257_NPK76-II-72-1_3 / 281_Alectinib_2 / 272_AR-42_2 / 274_Belinostat_1 / 306_Fedratinib_2 | other / cell_cyc / chromatin / erk_mapk / mitosis / pi3k / chromatin / other / other / other / other / pi3k / chromatin / other / rtk / rtk / pi3k / chromatin / mitosis / chromatin / cell_cyc / mitosis / rtk / chromatin / chromatin / other | 1_26457907_T_G / 5_141432375_A_C / 22_18847351_G_C / 1_219210601_T_G / 22_22643666_C_G |
| 14 | ZNF862_2 | 226_GSK1070916_2 / 346_THZ-2-102-1_3 / 310_YM201636_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 225_Genentech Cpd 10_3 / 222_BX-912_3 / 294_MPS-1-IN-1_3 / 301_PHA-793887_3 / 265_Tubastatin A_3 / 260_NG-25_3 / 290_KIN001-260_3 / 283_Omipalisib_2 / 331_QL-X-138_3 / 328_SNX-2112_3 / 299_OSI-027_2 / 287_KIN001-244_3 / 330_XMD13-2_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 256_JW-7-24-1_3 / 302_PI-103_3 / 211_TL-2-105_3 / 208_Ispinesib Mesylate_2 | mitosis / cell_cyc / other / other / mitosis / other / pi3k / mitosis / pi3k / mitosis / cell_cyc / chromatin / other / other / pi3k / other / other / tor / pi3k / other / pi3k / pi3k / other / pi3k / erk_mapk / mitosis | 1_26457907_T_G / 22_22759034_G_A |
| 15 | JAKMIP2_1 | 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 298_OSI-930_2 / 252_WZ3105_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 326_GSK690693_3 / 306_Fedratinib_2 / 253_XMD14-99_3 / 221_TAK-715_2 / 305_TPCA-1_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 301_PHA-793887_3 / 283_Omipalisib_2 / 211_TL-2-105_3 / 208_Ispinesib Mesylate_2 / 290_KIN001-260_3 / 292_Masitinib_1 / 185_Linsitinib_2 | other / pi3k / other / erk_mapk / mitosis / cell_cyc / other / rtk / other / g_integrity / mitosis / pi3k / other / rtk / jnk_p38 / other / other / rtk / cell_cyc / pi3k / erk_mapk / mitosis / other / rtk / igfr | 22_21127217_C_G |
| 16 | RHBDD2_2 | 326_GSK690693_3 / 283_Omipalisib_2 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 304_SB52334_3 / 185_Linsitinib_2 / 310_YM201636_3 / 223_ZSTK474_2 / 299_OSI-027_2 / 256_JW-7-24-1_3 / 331_QL-X-138_3 / 346_THZ-2-102-1_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 226_GSK1070916_2 / 302_PI-103_3 / 344_THZ-2-49_3 / 219_AT-7519_2 / 245_UNC0638_3 / 330_XMD13-2_3 / 225_Genentech Cpd 10_3 / 279_BIX02189_3 | pi3k / pi3k / other / mitosis / pi3k / rtk / igfr / other / pi3k / tor / other / other / cell_cyc / other / mitosis / mitosis / pi3k / cell_cyc / cell_cyc / chromatin / other / mitosis / other | 1_26457907_T_G / 22_30937565_T_G |
| 17 | NELL2_2 | 281_Alectinib_2 / 310_YM201636_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 276_CAY10603_3 / 273_CUDC-101_2 / 257_NPK76-II-72-1_3 / 274_Belinostat_1 / 252_WZ3105_3 / 265_Tubastatin A_3 / 263_FR-180204_3 / 346_THZ-2-102-1_3 / 303_PIK-93_3 / 290_KIN001-260_3 / 305_TPCA-1_3 / 272_AR-42_2 / 222_BX-912_3 / 256_JW-7-24-1_3 / 298_OSI-930_2 / 223_ZSTK474_2 | rtk / other / cell_cyc / mitosis / mitosis / other / pi3k / chromatin / chromatin / mitosis / chromatin / other / chromatin / erk_mapk / cell_cyc / pi3k / other / other / chromatin / pi3k / other / rtk / pi3k | 1_26457907_T_G / 5_141432375_A_C |
| 18 | LIPI_3_23 | 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 298_OSI-930_2 / 256_JW-7-24-1_3 / 305_TPCA-1_3 / 286_KIN001-236_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 326_GSK690693_3 / 341_Selisistat_3 / 1259_Talazoparib_3 / 271_VNLG/124_3 / 292_Masitinib_1 / 303_PIK-93_3 / 221_TAK-715_2 / 301_PHA-793887_3 / 304_SB52334_3 | erk_mapk / other / cell_cyc / mitosis / other / rtk / pi3k / other / rtk / other / other / other / other / other / pi3k / other / g_integrity / chromatin / rtk / pi3k / jnk_p38 / cell_cyc / rtk | 1_26457907_T_G / 5_141432375_A_C / 15_25177023_G_C |
| 19 | RUNX1_1 | 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 211_TL-2-105_3 / 253_XMD14-99_3 / 305_TPCA-1_3 / 225_Genentech Cpd 10_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 283_Omipalisib_2 / 221_TAK-715_2 / 223_ZSTK474_2 / 330_XMD13-2_3 / 303_PIK-93_3 / 326_GSK690693_3 / 136_Mitomycin-C_1 / 304_SB52334_3 / 301_PHA-793887_3 / 254_Quizartinib_2 / 252_WZ3105_3 / 346_THZ-2-102-1_3 | erk_mapk / other / pi3k / mitosis / other / erk_mapk / rtk / other / mitosis / cell_cyc / mitosis / pi3k / jnk_p38 / pi3k / other / pi3k / pi3k / DNArep / rtk / cell_cyc / rtk / other / cell_cyc | 1_26457907_T_G |
| 20 | UGT3A2_1 | 310_YM201636_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 252_WZ3105_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 299_OSI-027_2 / 256_JW-7-24-1_3 / 330_XMD13-2_3 / 152_CP466722_3 / 283_Omipalisib_2 / 271_VNLG/124_3 / 288_WHI-P97_3 / 1259_Talazoparib_3 / 286_KIN001-236_3 / 326_GSK690693_3 / 331_QL-X-138_3 / 223_ZSTK474_2 / 253_XMD14-99_3 / 290_KIN001-260_3 | other / erk_mapk / other / other / rtk / mitosis / cell_cyc / pi3k / pi3k / tor / other / other / g_integrity / pi3k / chromatin / other / g_integrity / other / pi3k / other / pi3k / rtk / other | 1_26457907_T_G |
| 21 | SLAIN1_2 | 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 281_Alectinib_2 / 226_GSK1070916_2 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 326_GSK690693_3 / 344_THZ-2-49_3 / 223_ZSTK474_2 / 256_JW-7-24-1_3 / 283_Omipalisib_2 / 299_OSI-027_2 / 305_TPCA-1_3 / 303_PIK-93_3 / 225_Genentech Cpd 10_3 / 346_THZ-2-102-1_3 / 152_CP466722_3 / 222_BX-912_3 | other / pi3k / erk_mapk / rtk / mitosis / other / mitosis / other / pi3k / cell_cyc / pi3k / other / pi3k / tor / other / pi3k / mitosis / cell_cyc / g_integrity / pi3k | 1_26457907_T_G / 22_21127217_C_G |
| 22 | TRPM4_3 | 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 283_Omipalisib_2 / 330_XMD13-2_3 / 1495_Olaparib_1 / 305_TPCA-1_3 / 304_SB52334_3 / 226_GSK1070916_2 / 257_NPK76-II-72-1_3 / 326_GSK690693_3 / 346_THZ-2-102-1_3 / 253_XMD14-99_3 / 271_VNLG/124_3 | erk_mapk / other / cell_cyc / other / mitosis / other / g_integrity / pi3k / pi3k / pi3k / other / g_integrity / other / rtk / mitosis / mitosis / pi3k / cell_cyc / rtk / chromatin | 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G |
| 23 | SLC24A3_1 | 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 271_VNLG/124_3 / 286_KIN001-236_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 253_XMD14-99_3 / 205_Avagacestat_2 / 281_Alectinib_2 / 326_GSK690693_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 298_OSI-930_2 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 1495_Olaparib_1 | erk_mapk / other / cell_cyc / chromatin / other / g_integrity / pi3k / other / rtk / other / rtk / pi3k / other / rtk / rtk / mitosis / pi3k / other / other / g_integrity | 22_22643666_C_G |
| 24 | NCKAP1L_1 | 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 256_JW-7-24-1_3 / 326_GSK690693_3 / 299_OSI-027_2 / 223_ZSTK474_2 / 304_SB52334_3 / 330_XMD13-2_3 / 283_Omipalisib_2 / 1259_Talazoparib_3 / 294_MPS-1-IN-1_3 / 331_QL-X-138_3 / 344_THZ-2-49_3 / 152_CP466722_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 271_VNLG/124_3 / 226_GSK1070916_2 | erk_mapk / other / pi3k / other / other / pi3k / tor / pi3k / rtk / other / pi3k / g_integrity / mitosis / other / cell_cyc / g_integrity / pi3k / other / chromatin / mitosis | 1_26457907_T_G |
| 25 | RAB32_3 | 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 326_GSK690693_3 / 252_WZ3105_3 / 222_BX-912_3 / 226_GSK1070916_2 / 290_KIN001-260_3 / 305_TPCA-1_3 / 330_XMD13-2_3 / 257_NPK76-II-72-1_3 / 263_FR-180204_3 / 281_Alectinib_2 / 256_JW-7-24-1_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 152_CP466722_3 / 254_Quizartinib_2 / 283_Omipalisib_2 | mitosis / pi3k / other / pi3k / other / pi3k / mitosis / other / other / other / mitosis / erk_mapk / rtk / other / pi3k / cell_cyc / g_integrity / rtk / pi3k | 1_26457907_T_G / 15_92992967_C_T / 5_141477711_A_G |
| 26 | E2F5_1 | 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 326_GSK690693_3 / 305_TPCA-1_3 / 226_GSK1070916_2 / 283_Omipalisib_2 / 290_KIN001-260_3 / 211_TL-2-105_3 / 304_SB52334_3 / 252_WZ3105_3 / 303_PIK-93_3 / 221_TAK-715_2 / 265_Tubastatin A_3 / 223_ZSTK474_2 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 | erk_mapk / other / mitosis / pi3k / rtk / pi3k / other / mitosis / pi3k / other / erk_mapk / rtk / other / pi3k / jnk_p38 / chromatin / pi3k / mitosis / other | 8_22080213_T_C |
| 27 | RBM11_5 | 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 226_GSK1070916_2 / 326_GSK690693_3 / 256_JW-7-24-1_3 / 1259_Talazoparib_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 223_ZSTK474_2 / 271_VNLG/124_3 / 253_XMD14-99_3 / 283_Omipalisib_2 | other / erk_mapk / cell_cyc / other / other / pi3k / mitosis / rtk / mitosis / pi3k / other / g_integrity / other / pi3k / pi3k / chromatin / rtk / pi3k | 1_26457907_T_G / 5_141432375_A_C / 12_52771095_C_G / 8_109483107_T_G / 22_18847351_G_C |
| 28 | JHDM1D_1 | 310_YM201636_3 / 279_BIX02189_3 / 252_WZ3105_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 263_FR-180204_3 / 256_JW-7-24-1_3 / 304_SB52334_3 / 286_KIN001-236_3 / 287_KIN001-244_3 / 223_ZSTK474_2 / 290_KIN001-260_3 / 288_WHI-P97_3 / 299_OSI-027_2 / 257_NPK76-II-72-1_3 / 253_XMD14-99_3 | other / other / other / other / pi3k / pi3k / erk_mapk / other / rtk / other / pi3k / pi3k / other / other / tor / mitosis / rtk | 22_21127217_C_G |
| 29 | SDC1_2 | 310_YM201636_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 211_TL-2-105_3 / 283_Omipalisib_2 / 305_TPCA-1_3 / 330_XMD13-2_3 / 290_KIN001-260_3 / 326_GSK690693_3 / 344_THZ-2-49_3 / 281_Alectinib_2 / 254_Quizartinib_2 / 263_FR-180204_3 | other / other / mitosis / mitosis / pi3k / pi3k / cell_cyc / erk_mapk / pi3k / other / other / other / pi3k / cell_cyc / rtk / rtk / erk_mapk | 1_26457907_T_G / 3_52520584_A_C |
| 30 | ENPP3_2 | 344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 303_PIK-93_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 346_THZ-2-102-1_3 / 226_GSK1070916_2 / 256_JW-7-24-1_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 281_Alectinib_2 / 331_QL-X-138_3 / 305_TPCA-1_3 | cell_cyc / other / other / erk_mapk / other / pi3k / pi3k / pi3k / cell_cyc / mitosis / other / mitosis / pi3k / rtk / other / other | 1_26457907_T_G / 22_22643666_C_G |
| 31 | RBM33_1 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 252_WZ3105_3 / 290_KIN001-260_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 346_THZ-2-102-1_3 / 305_TPCA-1_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 257_NPK76-II-72-1_3 / 299_OSI-027_2 / 331_QL-X-138_3 / 265_Tubastatin A_3 / 256_JW-7-24-1_3 / 330_XMD13-2_3 | mitosis / erk_mapk / other / other / other / cell_cyc / cell_cyc / other / pi3k / pi3k / mitosis / tor / other / chromatin / other / other | 1_26457907_T_G |
| 32 | MYOM2_1 | 263_FR-180204_3 / 310_YM201636_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 208_Ispinesib Mesylate_2 / 326_GSK690693_3 / 257_NPK76-II-72-1_3 / 221_TAK-715_2 / 290_KIN001-260_3 / 298_OSI-930_2 / 306_Fedratinib_2 / 344_THZ-2-49_3 | erk_mapk / other / mitosis / mitosis / other / other / pi3k / other / mitosis / pi3k / mitosis / jnk_p38 / other / rtk / other / cell_cyc | 1_26457907_T_G |
| 33 | ADRB1_1 | 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 326_GSK690693_3 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 290_KIN001-260_3 / 283_Omipalisib_2 / 185_Linsitinib_2 / 226_GSK1070916_2 / 305_TPCA-1_3 / 286_KIN001-236_3 / 221_TAK-715_2 | erk_mapk / other / cell_cyc / mitosis / other / pi3k / rtk / pi3k / other / other / pi3k / igfr / mitosis / other / other / jnk_p38 | 1_26457907_T_G |
| 34 | FAM19A5_1 | 310_YM201636_3 / 253_XMD14-99_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 211_TL-2-105_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 254_Quizartinib_2 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 330_XMD13-2_3 / 304_SB52334_3 / 256_JW-7-24-1_3 / 281_Alectinib_2 / 224_AS605240_3 | other / rtk / erk_mapk / pi3k / erk_mapk / pi3k / pi3k / rtk / other / mitosis / pi3k / other / rtk / other / rtk / pi3k | 22_22643666_C_G |
| 35 | CDK6_2 | 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 254_Quizartinib_2 / 211_TL-2-105_3 / 283_Omipalisib_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 223_ZSTK474_2 / 224_AS605240_3 / 306_Fedratinib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 282_Pelitinib_2 / 225_Genentech Cpd 10_3 / 281_Alectinib_2 / 221_TAK-715_2 | pi3k / rtk / rtk / erk_mapk / pi3k / mitosis / other / pi3k / pi3k / other / erk_mapk / other / egfr / mitosis / rtk / jnk_p38 | 6_31662176_A_G / 6_31662464_C_T |
| 36 | C1orf54_1 | 221_TAK-715_2 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 310_YM201636_3 / 341_Selisistat_3 / 298_OSI-930_2 / 330_XMD13-2_3 / 286_KIN001-236_3 / 346_THZ-2-102-1_3 / 328_SNX-2112_3 / 135_Gemcitabine_1 / 226_GSK1070916_2 / 260_NG-25_3 / 329_QL-XI-92_3 / 345_KIN001-270_3 / 292_Masitinib_1 | jnk_p38 / pi3k / erk_mapk / other / other / rtk / other / other / cell_cyc / other / DNArep / mitosis / other / rtk / cell_cyc / rtk | 8_22080213_T_C |
| 37 | HOOK1_1 | 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 271_VNLG/124_3 / 330_XMD13-2_3 / 304_SB52334_3 / 303_PIK-93_3 / 283_Omipalisib_2 / 226_GSK1070916_2 / 299_OSI-027_2 / 208_Ispinesib Mesylate_2 / 305_TPCA-1_3 / 1495_Olaparib_1 | erk_mapk / cell_cyc / other / other / mitosis / g_integrity / chromatin / other / rtk / pi3k / pi3k / mitosis / tor / mitosis / other / g_integrity | 1_26457907_T_G |
| 38 | EVI2A_1 | 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 221_TAK-715_2 / 283_Omipalisib_2 / 179_5-Fluorouracil_1 / 326_GSK690693_3 / 253_XMD14-99_3 / 330_XMD13-2_3 / 223_ZSTK474_2 / 238_Idelalisib_1 / 136_Mitomycin-C_1 / 305_TPCA-1_3 | pi3k / mitosis / other / mitosis / erk_mapk / jnk_p38 / pi3k / DNArep / pi3k / rtk / other / pi3k / pi3k / DNArep / other | 1_26457907_T_G |
| 39 | KDSR_1 | 310_YM201636_3 / 303_PIK-93_3 / 346_THZ-2-102-1_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 287_KIN001-244_3 / 344_THZ-2-49_3 / 328_SNX-2112_3 / 304_SB52334_3 / 330_XMD13-2_3 / 271_VNLG/124_3 / 1259_Talazoparib_3 | other / pi3k / cell_cyc / erk_mapk / other / mitosis / other / mitosis / pi3k / cell_cyc / other / rtk / other / chromatin / g_integrity | 22_21127217_C_G |
| 40 | TRIM69_1 | 310_YM201636_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 136_Mitomycin-C_1 / 179_5-Fluorouracil_1 / 300_CX-5461_3 / 305_TPCA-1_3 / 303_PIK-93_3 / 287_KIN001-244_3 / 328_SNX-2112_3 / 344_THZ-2-49_3 / 299_OSI-027_2 / 257_NPK76-II-72-1_3 / 263_FR-180204_3 / 1018_Veliparib_2 | other / mitosis / other / DNArep / DNArep / other / other / pi3k / pi3k / other / cell_cyc / tor / mitosis / erk_mapk / g_integrity | 22_21127217_C_G |
| 41 | FAM69A_1 | 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 1017_Olaparib_2 / 303_PIK-93_3 / 326_GSK690693_3 / 257_NPK76-II-72-1_3 / 304_SB52334_3 / 301_PHA-793887_3 / 253_XMD14-99_3 / 290_KIN001-260_3 / 226_GSK1070916_2 / 346_THZ-2-102-1_3 / 208_Ispinesib Mesylate_2 | other / mitosis / other / erk_mapk / g_integrity / pi3k / pi3k / mitosis / rtk / cell_cyc / rtk / other / mitosis / cell_cyc / mitosis | 4_105679196_A_C |
| 42 | MCF2_1 | 310_YM201636_3 / 344_THZ-2-49_3 / 290_KIN001-260_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 276_CAY10603_3 / 263_FR-180204_3 / 221_TAK-715_2 / 1259_Talazoparib_3 / 257_NPK76-II-72-1_3 / 274_Belinostat_1 / 253_XMD14-99_3 / 273_CUDC-101_2 / 228_AKT_inhibitor_VIII_3 | other / cell_cyc / other / mitosis / mitosis / other / chromatin / erk_mapk / jnk_p38 / g_integrity / mitosis / chromatin / rtk / chromatin / pi3k | 15_42142087_A_C |
| 43 | DNMT3A_1 | 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 286_KIN001-236_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 136_Mitomycin-C_1 / 326_GSK690693_3 / 305_TPCA-1_3 / 304_SB52334_3 / 205_Avagacestat_2 / 1091_BMS-536924_3 | erk_mapk / cell_cyc / other / other / mitosis / g_integrity / pi3k / other / other / DNArep / pi3k / other / rtk / other / igfr | 1_26457907_T_G |
| 44 | RAP1GAP_1 | 226_GSK1070916_2 / 310_YM201636_3 / 263_FR-180204_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 326_GSK690693_3 / 305_TPCA-1_3 / 252_WZ3105_3 / 290_KIN001-260_3 / 288_WHI-P97_3 / 299_OSI-027_2 | mitosis / other / erk_mapk / mitosis / other / cell_cyc / mitosis / pi3k / pi3k / other / other / other / other / tor | 1_26457907_T_G |
| 45 | GCNT1_2 | 221_TAK-715_2 / 330_XMD13-2_3 / 292_Masitinib_1 / 310_YM201636_3 / 208_Ispinesib Mesylate_2 / 301_PHA-793887_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 286_KIN001-236_3 / 298_OSI-930_2 / 263_FR-180204_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 | jnk_p38 / other / rtk / other / mitosis / cell_cyc / g_integrity / pi3k / rtk / other / rtk / erk_mapk / cell_cyc / mitosis | 22_22643666_C_G / 1_26457907_T_G |
| 46 | ACVR2B_1 | 228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 298_OSI-930_2 / 226_GSK1070916_2 / 330_XMD13-2_3 / 283_Omipalisib_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 253_XMD14-99_3 / 326_GSK690693_3 / 211_TL-2-105_3 / 208_Ispinesib Mesylate_2 / 225_Genentech Cpd 10_3 / 281_Alectinib_2 | pi3k / jnk_p38 / rtk / mitosis / other / pi3k / mitosis / other / rtk / pi3k / erk_mapk / mitosis / mitosis / rtk | 20_10639627_G_A |
| 47 | FLII_1 | 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 257_NPK76-II-72-1_3 / 263_FR-180204_3 / 226_GSK1070916_2 / 265_Tubastatin A_3 / 208_Ispinesib Mesylate_2 / 330_XMD13-2_3 / 288_WHI-P97_3 / 286_KIN001-236_3 / 252_WZ3105_3 / 305_TPCA-1_3 | mitosis / other / cell_cyc / other / mitosis / erk_mapk / mitosis / chromatin / mitosis / other / other / other / other / other | 3_52520584_A_C |
| 48 | TGS1_1 | 326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 281_Alectinib_2 / 330_XMD13-2_3 / 226_GSK1070916_2 / 253_XMD14-99_3 / 228_AKT_inhibitor_VIII_3 / 256_JW-7-24-1_3 / 279_BIX02189_3 | pi3k / erk_mapk / other / mitosis / mitosis / pi3k / other / rtk / other / mitosis / rtk / pi3k / other / other | 12_52771095_C_G |
| 49 | XG_2 | 310_YM201636_3 / 288_WHI-P97_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 304_SB52334_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 303_PIK-93_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 299_OSI-027_2 | other / other / other / erk_mapk / mitosis / other / rtk / cell_cyc / other / pi3k / pi3k / other / tor | 22_21127217_C_G / 1_26457907_T_G |
| 50 | PCDH17_2 | 344_THZ-2-49_3 / 281_Alectinib_2 / 252_WZ3105_3 / 330_XMD13-2_3 / 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 256_JW-7-24-1_3 / 326_GSK690693_3 / 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 | cell_cyc / rtk / other / other / other / erk_mapk / mitosis / pi3k / other / pi3k / mitosis / pi3k / pi3k | 1_26457907_T_G / 5_141432375_A_C |
| 51 | FCGRT_4 | 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 326_GSK690693_3 / 346_THZ-2-102-1_3 / 257_NPK76-II-72-1_3 | other / erk_mapk / cell_cyc / mitosis / other / g_integrity / pi3k / other / pi3k / other / pi3k / cell_cyc / mitosis | 1_26457907_T_G / 22_22643666_C_G / 5_141432375_A_C / 22_21127217_C_G |
| 52 | PPAPDC2_5 | 263_FR-180204_3 / 310_YM201636_3 / 1259_Talazoparib_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 1008_Methotrexate_1 / 290_KIN001-260_3 / 303_PIK-93_3 / 300_CX-5461_3 | erk_mapk / other / g_integrity / mitosis / cell_cyc / other / other / other / pi3k / DNArep / other / pi3k / other | 1_26457907_T_G / 15_42142087_A_C / 19_3179506_A_C / 8_22080213_T_C / 22_22643666_C_G |
| 53 | OTUD1_1 | 310_YM201636_3 / 252_WZ3105_3 / 306_Fedratinib_2 / 263_FR-180204_3 / 256_JW-7-24-1_3 / 254_Quizartinib_2 / 304_SB52334_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 225_Genentech Cpd 10_3 / 255_CP724714_2 / 271_VNLG/124_3 | other / other / other / erk_mapk / other / rtk / rtk / pi3k / other / other / mitosis / egfr / chromatin | 3_128992964_T_G |
| 54 | IRS2_2 | 344_THZ-2-49_3 / 310_YM201636_3 / 263_FR-180204_3 / 303_PIK-93_3 / 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 / 305_TPCA-1_3 / 304_SB52334_3 / 346_THZ-2-102-1_3 | cell_cyc / other / erk_mapk / pi3k / other / mitosis / pi3k / mitosis / other / other / rtk / cell_cyc | 1_26457907_T_G / 22_22643666_C_G |
| 55 | AKAP7_1 | 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 290_KIN001-260_3 / 305_TPCA-1_3 / 292_Masitinib_1 / 208_Ispinesib Mesylate_2 / 299_OSI-027_2 | erk_mapk / other / mitosis / cell_cyc / other / pi3k / other / other / other / rtk / mitosis / tor | 1_26457907_T_G |
| 56 | PCMTD2_1 | 304_SB52334_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 136_Mitomycin-C_1 / 252_WZ3105_3 / 152_CP466722_3 / 303_PIK-93_3 / 178_BAY-61-3606_3 | rtk / mitosis / other / pi3k / erk_mapk / other / pi3k / DNArep / other / g_integrity / pi3k / other | 1_26457907_T_G |
| 57 | ANXA11_1 | 305_TPCA-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 279_BIX02189_3 / 257_NPK76-II-72-1_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 253_XMD14-99_3 / 281_Alectinib_2 / 252_WZ3105_3 / 290_KIN001-260_3 | other / other / erk_mapk / mitosis / other / mitosis / pi3k / pi3k / rtk / rtk / other / other | 1_26457907_T_G |
| 58 | CYP4F22_1 | 310_YM201636_3 / 330_XMD13-2_3 / 211_TL-2-105_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 326_GSK690693_3 / 305_TPCA-1_3 | other / other / erk_mapk / pi3k / erk_mapk / other / mitosis / mitosis / mitosis / cell_cyc / pi3k / other | 22_21127217_C_G |
| 59 | FAH_1 | 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 288_WHI-P97_3 / 290_KIN001-260_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 252_WZ3105_3 / 303_PIK-93_3 / 291_KIN001-266_3 / 330_XMD13-2_3 | cell_cyc / mitosis / other / erk_mapk / other / other / mitosis / other / other / pi3k / other / other | 22_22643666_C_G |
| 60 | PRSS35_1 | 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 288_WHI-P97_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 305_TPCA-1_3 / 256_JW-7-24-1_3 / 1008_Methotrexate_1 / 1259_Talazoparib_3 | erk_mapk / other / pi3k / other / other / other / mitosis / cell_cyc / other / other / DNArep / g_integrity | 1_26457907_T_G |
| 61 | ARID2_1 | 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 | erk_mapk / other / mitosis / other / mitosis / cell_cyc / pi3k / pi3k / other / other / mitosis | 1_26457907_T_G |
| 62 | GBE1_2 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 226_GSK1070916_2 / 136_Mitomycin-C_1 / 330_XMD13-2_3 / 304_SB52334_3 / 303_PIK-93_3 | erk_mapk / mitosis / other / other / pi3k / pi3k / mitosis / DNArep / other / rtk / pi3k | 1_26457907_T_G / 22_22643666_C_G |
| 63 | FEZF1_2 | 310_YM201636_3 / 263_FR-180204_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 326_GSK690693_3 / 330_XMD13-2_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 | other / erk_mapk / other / g_integrity / pi3k / other / mitosis / cell_cyc / mitosis / pi3k / other | 1_26457907_T_G / 22_22643666_C_G |
| 64 | ACACB_2 | 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 263_FR-180204_3 / 1008_Methotrexate_1 / 252_WZ3105_3 / 326_GSK690693_3 / 222_BX-912_3 / 303_PIK-93_3 / 304_SB52334_3 | pi3k / other / mitosis / pi3k / erk_mapk / DNArep / other / pi3k / pi3k / pi3k / rtk | 1_26457907_T_G / 22_18847351_G_C |
| 65 | CUX2_1 | 330_XMD13-2_3 / 310_YM201636_3 / 299_OSI-027_2 / 304_SB52334_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 283_Omipalisib_2 / 331_QL-X-138_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 | other / other / tor / rtk / other / erk_mapk / pi3k / other / pi3k / pi3k / mitosis | 22_21127217_C_G |
| 66 | H2AFY2_1 | 1259_Talazoparib_3 / 263_FR-180204_3 / 310_YM201636_3 / 1495_Olaparib_1 / 136_Mitomycin-C_1 / 330_XMD13-2_3 / 271_VNLG/124_3 / 344_THZ-2-49_3 / 221_TAK-715_2 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 | g_integrity / erk_mapk / other / g_integrity / DNArep / other / chromatin / cell_cyc / jnk_p38 / mitosis / mitosis | 22_22643666_C_G |
| 67 | SCNN1G_1 | 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 252_WZ3105_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 288_WHI-P97_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 | erk_mapk / other / cell_cyc / other / g_integrity / pi3k / other / jnk_p38 / other / mitosis / pi3k | 1_26457907_T_G |
| 68 | MICAL2_1 | 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 / 310_YM201636_3 / 283_Omipalisib_2 / 211_TL-2-105_3 / 253_XMD14-99_3 / 294_MPS-1-IN-1_3 / 221_TAK-715_2 / 330_XMD13-2_3 / 263_FR-180204_3 / 254_Quizartinib_2 | pi3k / pi3k / other / pi3k / erk_mapk / rtk / mitosis / jnk_p38 / other / erk_mapk / rtk | 6_151015603_C_G |
| 69 | SWT1_2 | 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 253_XMD14-99_3 / 211_TL-2-105_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 221_TAK-715_2 / 283_Omipalisib_2 / 252_WZ3105_3 / 226_GSK1070916_2 | other / pi3k / cell_cyc / rtk / erk_mapk / erk_mapk / other / jnk_p38 / pi3k / other / mitosis | 1_26457907_T_G / 8_109483107_T_G |
| 70 | PDE6B_1 | 286_KIN001-236_3 / 263_FR-180204_3 / 1259_Talazoparib_3 / 310_YM201636_3 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 206_Ruxolitinib_1 / 1012_Vorinostat_1 / 330_XMD13-2_3 / 341_Selisistat_3 | other / erk_mapk / g_integrity / other / rtk / pi3k / mitosis / other / chromatin / other / other | 15_42142087_A_C |
| 71 | FUT11_4 | 310_YM201636_3 / 288_WHI-P97_3 / 330_XMD13-2_3 / 286_KIN001-236_3 / 291_KIN001-266_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 | other / other / other / other / other / cell_cyc / pi3k / rtk / other / mitosis | 1_26457907_T_G / 22_24252424_G_C / 22_21127217_C_G / 22_22643666_C_G |
| 72 | CRMP1_2 | 299_OSI-027_2 / 310_YM201636_3 / 256_JW-7-24-1_3 / 305_TPCA-1_3 / 274_Belinostat_1 / 263_FR-180204_3 / 276_CAY10603_3 / 330_XMD13-2_3 / 226_GSK1070916_2 / 272_AR-42_2 | tor / other / other / other / chromatin / erk_mapk / chromatin / other / mitosis / chromatin | 22_21127217_C_G / 1_26457907_T_G |
| 73 | ATP2B3_2 | 281_Alectinib_2 / 310_YM201636_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 / 305_TPCA-1_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 290_KIN001-260_3 | rtk / other / other / pi3k / mitosis / mitosis / other / erk_mapk / cell_cyc / other | 1_26457907_T_G / 17_7604041_A_C |
| 74 | KLHL23_2 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 253_XMD14-99_3 / 281_Alectinib_2 / 304_SB52334_3 / 305_TPCA-1_3 / 185_Linsitinib_2 / 326_GSK690693_3 | erk_mapk / mitosis / pi3k / other / rtk / rtk / rtk / other / igfr / pi3k | 1_26457907_T_G / 5_141432375_A_C |
| 75 | PNMAL1_1 | 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 344_THZ-2-49_3 / 346_THZ-2-102-1_3 / 283_Omipalisib_2 / 261_TL-1-85_3 / 228_AKT_inhibitor_VIII_3 | other / mitosis / mitosis / pi3k / other / cell_cyc / cell_cyc / pi3k / other / pi3k | 1_26457907_T_G |
| 76 | DPP9_1 | 263_FR-180204_3 / 1008_Methotrexate_1 / 185_Linsitinib_2 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 / 304_SB52334_3 / 326_GSK690693_3 | erk_mapk / DNArep / igfr / pi3k / mitosis / mitosis / other / other / rtk / pi3k | 22_21127217_C_G |
| 77 | GPC2_1 | 228_AKT_inhibitor_VIII_3 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 / 330_XMD13-2_3 / 283_Omipalisib_2 / 226_GSK1070916_2 / 252_WZ3105_3 | pi3k / igfr / mitosis / pi3k / erk_mapk / other / other / pi3k / mitosis / other | 5_141432375_A_C |
| 78 | RBM27_1 | 330_XMD13-2_3 / 265_Tubastatin A_3 / 344_THZ-2-49_3 / 294_MPS-1-IN-1_3 / 271_VNLG/124_3 / 326_GSK690693_3 / 273_CUDC-101_2 / 226_GSK1070916_2 / 310_YM201636_3 / 263_FR-180204_3 | other / chromatin / cell_cyc / mitosis / chromatin / pi3k / chromatin / mitosis / other / erk_mapk | 19_48617887_T_G |
| 79 | HOXD13_1 | 344_THZ-2-49_3 / 263_FR-180204_3 / 298_OSI-930_2 / 1248_Daporinad_3 / 1259_Talazoparib_3 / 1091_BMS-536924_3 / 310_YM201636_3 / 136_Mitomycin-C_1 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 | cell_cyc / erk_mapk / rtk / metabol / g_integrity / igfr / other / DNArep / pi3k / mitosis | 1_26457907_T_G |
| 80 | TFCP2_1 | 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 326_GSK690693_3 / 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 252_WZ3105_3 / 298_OSI-930_2 / 330_XMD13-2_3 | mitosis / mitosis / erk_mapk / pi3k / rtk / pi3k / other / other / rtk / other | 19_55796171_G_T |
| 81 | MLC1_2 | 310_YM201636_3 / 1011_Navitoclax_2 / 344_THZ-2-49_3 / 263_FR-180204_3 / 303_PIK-93_3 / 288_WHI-P97_3 / 228_AKT_inhibitor_VIII_3 / 346_THZ-2-102-1_3 / 252_WZ3105_3 | other / apop / cell_cyc / erk_mapk / pi3k / other / pi3k / cell_cyc / other | 1_26457907_T_G / 7_72941936_T_C |
| 82 | NUDT10_1 | 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 / 326_GSK690693_3 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 281_Alectinib_2 | other / pi3k / mitosis / pi3k / pi3k / other / mitosis / other / rtk | 1_26457907_T_G |
| 83 | ABHD6_5 | 344_THZ-2-49_3 / 310_YM201636_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 257_NPK76-II-72-1_3 / 273_CUDC-101_2 / 265_Tubastatin A_3 | cell_cyc / other / other / pi3k / mitosis / other / mitosis / chromatin / chromatin | 12_52771095_C_G / 1_26457907_T_G / 22_18847351_G_C / 5_141432375_A_C / 22_21127217_C_G |
| 84 | NDST4_2 | 310_YM201636_3 / 252_WZ3105_3 / 263_FR-180204_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 283_Omipalisib_2 | other / other / erk_mapk / other / cell_cyc / pi3k / mitosis / other / pi3k | 1_26457907_T_G / 1_219210601_T_G |
| 85 | POU3F2_5 | 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 226_GSK1070916_2 / 330_XMD13-2_3 / 263_FR-180204_3 / 346_THZ-2-102-1_3 / 257_NPK76-II-72-1_3 / 281_Alectinib_2 | cell_cyc / other / other / mitosis / other / erk_mapk / cell_cyc / mitosis / rtk | 1_26457907_T_G / 5_141432375_A_C / 1_219210601_T_G / 1_205381583_C_G / 3_52520584_A_C |
| 86 | RND2_1 | 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 305_TPCA-1_3 / 304_SB52334_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 221_TAK-715_2 / 253_XMD14-99_3 | erk_mapk / pi3k / other / other / rtk / mitosis / other / jnk_p38 / rtk | 1_26457907_T_G |
| 87 | TEKT2_1 | 263_FR-180204_3 / 185_Linsitinib_2 / 344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 271_VNLG/124_3 | erk_mapk / igfr / cell_cyc / other / other / pi3k / pi3k / mitosis / chromatin | 1_26457907_T_G |
| 88 | RCOR1_1 | 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 / 257_NPK76-II-72-1_3 / 330_XMD13-2_3 | erk_mapk / other / mitosis / cell_cyc / mitosis / pi3k / other / mitosis / other | 1_176702776_TGAGAGAGA_T |
| 89 | SH3GLB1_1 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 / 1264_SGC0946_3 / 253_XMD14-99_3 / 265_Tubastatin A_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 228_AKT_inhibitor_VIII_3 | erk_mapk / mitosis / other / chromatin / rtk / chromatin / other / other / pi3k | 22_22643666_C_G |
| 90 | ZCCHC5_1 | 294_MPS-1-IN-1_3 / 179_5-Fluorouracil_1 / 283_Omipalisib_2 / 300_CX-5461_3 / 136_Mitomycin-C_1 / 208_Ispinesib Mesylate_2 / 299_OSI-027_2 / 302_PI-103_3 / 151_QS11_3 | mitosis / DNArep / pi3k / other / DNArep / mitosis / tor / pi3k / other | 22_22643666_C_G |
| 91 | EVI2B_1 | 310_YM201636_3 / 326_GSK690693_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 298_OSI-930_2 / 228_AKT_inhibitor_VIII_3 / 136_Mitomycin-C_1 / 344_THZ-2-49_3 / 211_TL-2-105_3 | other / pi3k / g_integrity / mitosis / rtk / pi3k / DNArep / cell_cyc / erk_mapk | 10_46462341_C_A |
| 92 | EPC1_2 | 310_YM201636_3 / 263_FR-180204_3 / 1259_Talazoparib_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 303_PIK-93_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 226_GSK1070916_2 | other / erk_mapk / g_integrity / other / other / pi3k / mitosis / other / mitosis | 19_6744459_C_G / 19_42723940_A_C |
| 93 | VAX1_2 | 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 226_GSK1070916_2 | other / erk_mapk / cell_cyc / pi3k / pi3k / other / mitosis / mitosis | 1_26457907_T_G / 22_21127217_C_G |
| 94 | DLG2_3 | 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 185_Linsitinib_2 / 304_SB52334_3 / 305_TPCA-1_3 | erk_mapk / other / mitosis / pi3k / cell_cyc / igfr / rtk / other | 22_21127217_C_G / 22_18847351_G_C / 1_26457907_T_G |
| 95 | PPP1R1A_2 | 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 | other / erk_mapk / cell_cyc / pi3k / other / other / pi3k / mitosis | 1_26457907_T_G / 5_141432375_A_C |
| 96 | EFNB1_1 | 344_THZ-2-49_3 / 252_WZ3105_3 / 310_YM201636_3 / 256_JW-7-24-1_3 / 263_FR-180204_3 / 299_OSI-027_2 / 330_XMD13-2_3 / 281_Alectinib_2 | cell_cyc / other / other / other / erk_mapk / tor / other / rtk | 1_26457907_T_G |
| 97 | POU3F1_2 | 263_FR-180204_3 / 310_YM201636_3 / 1259_Talazoparib_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 303_PIK-93_3 / 330_XMD13-2_3 / 228_AKT_inhibitor_VIII_3 | erk_mapk / other / g_integrity / mitosis / mitosis / pi3k / other / pi3k | 1_26457907_T_G / 22_22643666_C_G |
| 98 | JPH1_2 | 263_FR-180204_3 / 344_THZ-2-49_3 / 185_Linsitinib_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 310_YM201636_3 / 252_WZ3105_3 / 298_OSI-930_2 | erk_mapk / cell_cyc / igfr / mitosis / pi3k / other / other / rtk | 1_26457907_T_G / 19_32643405_T_C |
| 99 | LGALS3_5 | 281_Alectinib_2 / 330_XMD13-2_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 326_GSK690693_3 / 252_WZ3105_3 / 226_GSK1070916_2 / 228_AKT_inhibitor_VIII_3 | rtk / other / other / cell_cyc / pi3k / other / mitosis / pi3k | 1_26457907_T_G / 5_141432375_A_C / 3_51333222_A_C / 7_100760409_A_C / 22_24252424_G_C |
| 100 | LRRC4B_1 | 310_YM201636_3 / 303_PIK-93_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 305_TPCA-1_3 / 283_Omipalisib_2 / 346_THZ-2-102-1_3 / 226_GSK1070916_2 | other / pi3k / erk_mapk / pi3k / other / pi3k / cell_cyc / mitosis | 22_21127217_C_G |
| 101 | ARHGAP19_1 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 330_XMD13-2_3 / 305_TPCA-1_3 / 226_GSK1070916_2 | erk_mapk / mitosis / other / pi3k / jnk_p38 / other / other / mitosis | 22_22643666_C_G |
| 102 | MYL9_1 | 310_YM201636_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 / 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 263_FR-180204_3 | other / other / cell_cyc / mitosis / mitosis / pi3k / erk_mapk | 1_26457907_T_G |
| 103 | TMEM170B_1 | 294_MPS-1-IN-1_3 / 310_YM201636_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 305_TPCA-1_3 / 326_GSK690693_3 | mitosis / other / erk_mapk / pi3k / rtk / other / pi3k | 1_26457907_T_G |
| 104 | CSAD_1 | 326_GSK690693_3 / 283_Omipalisib_2 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 257_NPK76-II-72-1_3 / 228_AKT_inhibitor_VIII_3 / 252_WZ3105_3 | pi3k / pi3k / other / mitosis / mitosis / pi3k / other | 1_26457907_T_G |
| 105 | ASGR1_5 | 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 288_WHI-P97_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 | erk_mapk / other / cell_cyc / other / pi3k / mitosis / other | 22_22643666_C_G / 1_26457907_T_G / 15_42142087_A_C / 22_21127217_C_G / 5_141432375_A_C |
| 106 | KIAA1958_1 | 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 223_ZSTK474_2 / 226_GSK1070916_2 / 305_TPCA-1_3 | other / erk_mapk / mitosis / pi3k / pi3k / mitosis / other | 1_26457907_T_G |
| 107 | NPW_2 | 310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 226_GSK1070916_2 / 288_WHI-P97_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 | other / cell_cyc / erk_mapk / mitosis / other / other / pi3k | 1_26457907_T_G / 3_52520584_A_C |
| 108 | CAP1_1 | 263_FR-180204_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 290_KIN001-260_3 / 136_Mitomycin-C_1 / 286_KIN001-236_3 | erk_mapk / other / mitosis / other / other / DNArep / other | 1_26457907_T_G |
| 109 | SIAH3_1 | 344_THZ-2-49_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 263_FR-180204_3 / 286_KIN001-236_3 / 253_XMD14-99_3 | cell_cyc / other / mitosis / other / erk_mapk / other / rtk | 1_26457907_T_G |
| 110 | PALM3_1 | 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 326_GSK690693_3 / 283_Omipalisib_2 / 271_VNLG/124_3 / 304_SB52334_3 | erk_mapk / pi3k / mitosis / pi3k / pi3k / chromatin / rtk | 22_22643666_C_G |
| 111 | STMN3_1 | 303_PIK-93_3 / 260_NG-25_3 / 300_CX-5461_3 / 287_KIN001-244_3 / 305_TPCA-1_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 | pi3k / other / other / pi3k / other / other / mitosis | 6_110102054_T_G |
| 112 | TMEM81_1 | 263_FR-180204_3 / 344_THZ-2-49_3 / 326_GSK690693_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 226_GSK1070916_2 | erk_mapk / cell_cyc / pi3k / other / mitosis / other / mitosis | 19_7056560_G_T |
| 113 | SPATA6L_2 | 263_FR-180204_3 / 1259_Talazoparib_3 / 310_YM201636_3 / 271_VNLG/124_3 / 286_KIN001-236_3 / 304_SB52334_3 / 1008_Methotrexate_1 | erk_mapk / g_integrity / other / chromatin / other / rtk / DNArep | 8_1678462_A_C / 1_26457907_T_G |
| 114 | CSRP2BP_5 | 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 326_GSK690693_3 | pi3k / other / cell_cyc / mitosis / mitosis / erk_mapk / pi3k | 1_26457907_T_G / 17_65225089_T_C / 1_205381583_C_G / 17_7318141_T_G / 16_22266423_T_C |
| 115 | MAP2K6_1 | 228_AKT_inhibitor_VIII_3 / 221_TAK-715_2 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 330_XMD13-2_3 / 253_XMD14-99_3 / 310_YM201636_3 | pi3k / jnk_p38 / erk_mapk / mitosis / other / rtk / other | 6_151015603_C_G |
| 116 | HOXB13_1 | 263_FR-180204_3 / 1008_Methotrexate_1 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 286_KIN001-236_3 | erk_mapk / DNArep / mitosis / other / pi3k / g_integrity / other | 1_26457907_T_G |
| 117 | RBM12B_1 | 326_GSK690693_3 / 294_MPS-1-IN-1_3 / 304_SB52334_3 / 263_FR-180204_3 / 290_KIN001-260_3 / 253_XMD14-99_3 / 305_TPCA-1_3 | pi3k / mitosis / rtk / erk_mapk / other / rtk / other | 8_131984112_C_T |
| 118 | ADRB3_1 | 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 / 288_WHI-P97_3 | erk_mapk / other / cell_cyc / pi3k / mitosis / other | 1_26457907_T_G |
| 119 | LUC7L_5 | 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 281_Alectinib_2 / 326_GSK690693_3 | erk_mapk / pi3k / other / mitosis / rtk / pi3k | 1_26457907_T_G / 22_22643666_C_G / 22_21127217_C_G / 15_50544697_C_A / 5_141432375_A_C |
| 120 | ITM2A_1 | 344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3 / 330_XMD13-2_3 / 256_JW-7-24-1_3 | cell_cyc / erk_mapk / other / other / other / other | 1_26457907_T_G |
| 121 | ICAM4_1 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 298_OSI-930_2 / 344_THZ-2-49_3 | erk_mapk / mitosis / other / pi3k / rtk / cell_cyc | 1_26457907_T_G |
| 122 | HMCN1_1 | 310_YM201636_3 / 252_WZ3105_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 283_Omipalisib_2 / 344_THZ-2-49_3 | other / other / erk_mapk / pi3k / pi3k / cell_cyc | 1_26457907_T_G |
| 123 | ZNF397_4 | 310_YM201636_3 / 276_CAY10603_3 / 245_UNC0638_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 303_PIK-93_3 | other / chromatin / chromatin / mitosis / erk_mapk / pi3k | 22_22643666_C_G / 22_21127217_C_G / 15_56693096_A_C / 1_26457907_T_G |
| 124 | DRAP1_1 | 305_TPCA-1_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 290_KIN001-260_3 | other / mitosis / erk_mapk / other / pi3k / other | 1_26457907_T_G |
| 125 | DTX3L_1 | 305_TPCA-1_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 / 257_NPK76-II-72-1_3 / 290_KIN001-260_3 | other / other / mitosis / erk_mapk / mitosis / other | 1_26457907_T_G |
| 126 | NUDT11_5 | 310_YM201636_3 / 281_Alectinib_2 / 344_THZ-2-49_3 / 257_NPK76-II-72-1_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 | other / rtk / cell_cyc / mitosis / other / mitosis | 1_26457907_T_G / 5_141432375_A_C / 12_52771095_C_G / 1_219210601_T_G / 22_18847351_G_C |
| 127 | ADAM19_3 | 265_Tubastatin A_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 310_YM201636_3 / 271_VNLG/124_3 | chromatin / erk_mapk / mitosis / other / other / chromatin | 22_21127217_C_G / 22_21283300_G_C / 14_68882917_A_G |
| 128 | HS3ST4_2 | 263_FR-180204_3 / 310_YM201636_3 / 326_GSK690693_3 / 228_AKT_inhibitor_VIII_3 / 330_XMD13-2_3 / 344_THZ-2-49_3 | erk_mapk / other / pi3k / pi3k / other / cell_cyc | 1_26457907_T_G / 12_52771095_C_G |
| 129 | CRIPAK_4 | 346_THZ-2-102-1_3 / 261_TL-1-85_3 / 303_PIK-93_3 / 287_KIN001-244_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 | cell_cyc / other / pi3k / pi3k / mitosis / other | 9_137101572_A_C / 4_48557504_A_G / 6_160247199_T_G / 7_44697564_T_G |
| 130 | OLFM3_1 | 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 / 330_XMD13-2_3 / 252_WZ3105_3 / 298_OSI-930_2 | erk_mapk / cell_cyc / other / other / other / rtk | 22_22643666_C_G |
| 131 | LMO2_4 | 344_THZ-2-49_3 / 263_FR-180204_3 / 281_Alectinib_2 / 310_YM201636_3 / 1259_Talazoparib_3 / 252_WZ3105_3 | cell_cyc / erk_mapk / rtk / other / g_integrity / other | 5_141432375_A_C / 1_26457907_T_G / 11_1246628_A_C / 15_25177023_G_C |
| 132 | SALL2_1 | 263_FR-180204_3 / 1008_Methotrexate_1 / 310_YM201636_3 / 294_MPS-1-IN-1_3 / 1259_Talazoparib_3 / 228_AKT_inhibitor_VIII_3 | erk_mapk / DNArep / other / mitosis / g_integrity / pi3k | 22_22643666_C_G |
| 133 | SLC35F3_1 | 1495_Olaparib_1 / 330_XMD13-2_3 / 1259_Talazoparib_3 / 344_THZ-2-49_3 / 286_KIN001-236_3 / 310_YM201636_3 | g_integrity / other / g_integrity / cell_cyc / other / other | 15_42142087_A_C |
| 134 | RHOH_1 | 310_YM201636_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 290_KIN001-260_3 / 344_THZ-2-49_3 / 305_TPCA-1_3 | other / erk_mapk / mitosis / other / cell_cyc / other | 22_21127217_C_G |
| 135 | MED23_1 | 344_THZ-2-49_3 / 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 265_Tubastatin A_3 / 310_YM201636_3 / 290_KIN001-260_3 | cell_cyc / erk_mapk / mitosis / chromatin / other / other | 15_42142087_A_C |
| 136 | ALS2CR8_2 | 310_YM201636_3 / 271_VNLG/124_3 / 228_AKT_inhibitor_VIII_3 / 1259_Talazoparib_3 / 326_GSK690693_3 / 283_Omipalisib_2 | other / chromatin / pi3k / g_integrity / pi3k / pi3k | 7_5300364_T_G / 11_64118302_A_C |
| 137 | PDS5B_1 | 226_GSK1070916_2 / 281_Alectinib_2 / 253_XMD14-99_3 / 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 / 263_FR-180204_3 | mitosis / rtk / rtk / pi3k / pi3k / erk_mapk | 19_5654163_A_C |
| 138 | POU4F1_1 | 252_WZ3105_3 / 310_YM201636_3 / 226_GSK1070916_2 / 344_THZ-2-49_3 / 222_BX-912_3 / 330_XMD13-2_3 | other / other / mitosis / cell_cyc / pi3k / other | X_149503442_T_G |
| 139 | LINGO1_4 | 263_FR-180204_3 / 310_YM201636_3 / 305_TPCA-1_3 / 288_WHI-P97_3 / 294_MPS-1-IN-1_3 | erk_mapk / other / other / other / mitosis | 22_22643666_C_G / 22_21127217_C_G / 1_26457907_T_G / 11_66624536_A_C |
| 140 | EZH2_2 | 310_YM201636_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 / 252_WZ3105_3 / 228_AKT_inhibitor_VIII_3 | other / pi3k / mitosis / other / pi3k | 1_26457907_T_G / 22_18847351_G_C |
| 141 | ZNF786_5 | 252_WZ3105_3 / 294_MPS-1-IN-1_3 / 283_Omipalisib_2 / 310_YM201636_3 / 326_GSK690693_3 | other / mitosis / pi3k / other / pi3k | 1_26457907_T_G / 17_7604041_A_C / 17_78120770_A_C / 22_30937565_T_G / 16_25177910_T_G |
| 142 | SLCO5A1_1 | 263_FR-180204_3 / 310_YM201636_3 / 304_SB52334_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 | erk_mapk / other / rtk / other / mitosis | 1_26457907_T_G |
| 143 | DKK2_1 | 310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 299_OSI-027_2 / 294_MPS-1-IN-1_3 | other / cell_cyc / erk_mapk / tor / mitosis | 1_26457907_T_G |
| 144 | ATP11C_1 | 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 273_CUDC-101_2 / 330_XMD13-2_3 | cell_cyc / other / other / chromatin / other | 1_26457907_T_G |
| 145 | KMO_1 | 310_YM201636_3 / 263_FR-180204_3 / 303_PIK-93_3 / 305_TPCA-1_3 / 294_MPS-1-IN-1_3 | other / erk_mapk / pi3k / other / mitosis | 22_21127217_C_G |
| 146 | SPOCD1_1 | 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 253_XMD14-99_3 / 286_KIN001-236_3 | erk_mapk / pi3k / other / rtk / other | 1_26457907_T_G |
| 147 | LMO3_1 | 228_AKT_inhibitor_VIII_3 / 310_YM201636_3 / 223_ZSTK474_2 / 252_WZ3105_3 / 211_TL-2-105_3 | pi3k / other / pi3k / other / erk_mapk | 1_26457907_T_G |
| 148 | SUCLG2_1 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1242_(5Z)-7-Oxozeaenol_3 / 1014_Refametinib_2 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / other / erk_mapk / erk_mapk | 3_160423378_C_T |
| 149 | CDC42EP3_1 | 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 305_TPCA-1_3 / 226_GSK1070916_2 | mitosis / pi3k / erk_mapk / other / mitosis | 22_21283300_G_C |
| 150 | VIM_2 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 / 1014_Refametinib_2 / 1060_PD0325901_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk / erk_mapk | 13_99295007_C_T / 13_99314037_A_G |
| 151 | KIAA1456_5 | 263_FR-180204_3 / 288_WHI-P97_3 / 344_THZ-2-49_3 / 310_YM201636_3 | erk_mapk / other / cell_cyc / other | 1_26457907_T_G / 22_21127217_C_G / 22_22643666_C_G / 3_52520584_A_C / 15_25177023_G_C |
| 152 | ATP1A1_1 | 344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3 | cell_cyc / erk_mapk / other / other | 1_26457907_T_G |
| 153 | EFHD2_3 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 305_TPCA-1_3 / 310_YM201636_3 | erk_mapk / mitosis / other / other | 1_26457907_T_G / 19_3179506_A_C / 12_48769033_A_C |
| 154 | NPY1R_1 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 344_THZ-2-49_3 / 310_YM201636_3 | erk_mapk / mitosis / cell_cyc / other | 1_26457907_T_G |
| 155 | PTPN13_1 | 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 / 330_XMD13-2_3 | cell_cyc / other / other / other | 1_26457907_T_G |
| 156 | SOX11_3 | 344_THZ-2-49_3 / 263_FR-180204_3 / 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 | cell_cyc / erk_mapk / other / pi3k | 1_26457907_T_G / 22_21127217_C_G / 5_141432375_A_C |
| 157 | RAVER2_1 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 226_GSK1070916_2 | erk_mapk / mitosis / other / mitosis | 1_26457907_T_G |
| 158 | CD44_3 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 / 226_GSK1070916_2 | erk_mapk / mitosis / pi3k / mitosis | 1_149813302_A_C / 1_26457907_T_G / 6_151015603_C_G |
| 159 | WIPI1_1 | 263_FR-180204_3 / 281_Alectinib_2 / 310_YM201636_3 / 305_TPCA-1_3 | erk_mapk / rtk / other / other | 1_26457907_T_G |
| 160 | MEIG1_1 | 310_YM201636_3 / 228_AKT_inhibitor_VIII_3 / 344_THZ-2-49_3 / 281_Alectinib_2 | other / pi3k / cell_cyc / rtk | 5_141636680_A_C |
| 161 | ITGAV_1 | 1526_Refametinib_3 / 1014_Refametinib_2 / 1372_Trametinib_1 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 3_180647255_T_TA |
| 162 | WASF1_2 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 / 310_YM201636_3 / 305_TPCA-1_3 | erk_mapk / mitosis / other / other | 22_22643666_C_G / 22_21127217_C_G |
| 163 | SEPT5_1 | 263_FR-180204_3 / 310_YM201636_3 / 304_SB52334_3 / 228_AKT_inhibitor_VIII_3 | erk_mapk / other / rtk / pi3k | 1_26457907_T_G |
| 164 | ZNF703_4 | 263_FR-180204_3 / 310_YM201636_3 / 344_THZ-2-49_3 / 304_SB52334_3 | erk_mapk / other / cell_cyc / rtk | 15_42142087_A_C / 19_3179506_A_C / 22_22643666_C_G / 10_71362188_T_C |
| 165 | RCAN1_1 | 310_YM201636_3 / 1259_Talazoparib_3 / 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 | other / g_integrity / erk_mapk / pi3k | 22_22643666_C_G |
| 166 | MEIS1_1 | 310_YM201636_3 / 344_THZ-2-49_3 / 263_FR-180204_3 / 330_XMD13-2_3 | other / cell_cyc / erk_mapk / other | 11_1246619_A_C |
| 167 | DOCK9_2 | 1014_Refametinib_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 / 1372_Trametinib_1 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 17_80065379_A_G / 2_87800520_G_A |
| 168 | MAP2K1_1 | 301_PHA-793887_3 / 1259_Talazoparib_3 / 263_FR-180204_3 / 330_XMD13-2_3 | cell_cyc / g_integrity / erk_mapk / other | 22_21127217_C_G |
| 169 | BAZ2A_1 | 263_FR-180204_3 / 298_OSI-930_2 / 294_MPS-1-IN-1_3 / 228_AKT_inhibitor_VIII_3 | erk_mapk / rtk / mitosis / pi3k | 19_46321845_A_C |
| 170 | TMEM70_2 | 252_WZ3105_3 / 310_YM201636_3 / 303_PIK-93_3 / 301_PHA-793887_3 | other / other / pi3k / cell_cyc | 1_26457907_T_G / 10_35032524_A_C |
| 171 | CSRP3_1 | 294_MPS-1-IN-1_3 / 328_SNX-2112_3 / 346_THZ-2-102-1_3 / 310_YM201636_3 | mitosis / other / cell_cyc / other | 2_112722995_T_G |
| 172 | MSRB3_1 | 1372_Trametinib_1 / 1060_PD0325901_2 / 1526_Refametinib_3 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk / erk_mapk | 22_37816755_A_G |
| 173 | PTGER2_1 | 263_FR-180204_3 / 253_XMD14-99_3 / 306_Fedratinib_2 / 1495_Olaparib_1 | erk_mapk / rtk / other / g_integrity | 20_49068783_G_C |
| 174 | ARHGAP44_2 | 1248_Daporinad_3 / 344_THZ-2-49_3 / 1495_Olaparib_1 / 1259_Talazoparib_3 | metabol / cell_cyc / g_integrity / g_integrity | 16_55810697_G_T / 16_55813139_C_T |
| 175 | TTC7A_2 | 326_GSK690693_3 / 310_YM201636_3 / 330_XMD13-2_3 / 254_Quizartinib_2 | pi3k / other / other / rtk | 11_92353347_C_T / 11_92353483_G_A |
| 176 | SLC35F1_1 | 310_YM201636_3 / 263_FR-180204_3 / 344_THZ-2-49_3 | other / erk_mapk / cell_cyc | 1_26457907_T_G |
| 177 | KRT25_4 | 330_XMD13-2_3 / 310_YM201636_3 / 294_MPS-1-IN-1_3 | other / other / mitosis | 22_21127217_C_G / 1_26457907_T_G / 22_22643666_C_G / 22_24658344_C_G |
| 178 | PAX7_1 | 263_FR-180204_3 / 310_YM201636_3 / 326_GSK690693_3 | erk_mapk / other / pi3k | 1_26457907_T_G |
| 179 | ENC1_1 | 263_FR-180204_3 / 310_YM201636_3 / 252_WZ3105_3 | erk_mapk / other / other | 1_26457907_T_G |
| 180 | ERO1L_3 | 281_Alectinib_2 / 263_FR-180204_3 / 326_GSK690693_3 | rtk / erk_mapk / pi3k | 1_26457907_T_G / 5_141432375_A_C / 10_6515090_A_C |
| 181 | KANSL2_2 | 281_Alectinib_2 / 226_GSK1070916_2 / 310_YM201636_3 | rtk / mitosis / other | 1_26457907_T_G / 12_94248247_C_T |
| 182 | RPN1_3 | 344_THZ-2-49_3 / 286_KIN001-236_3 / 310_YM201636_3 | cell_cyc / other / other | 22_22643666_C_G / 5_141432375_A_C / 1_26457907_T_G |
| 183 | PTGER3_2 | 344_THZ-2-49_3 / 310_YM201636_3 / 252_WZ3105_3 | cell_cyc / other / other | 1_26457907_T_G / 1_219210601_T_G |
| 184 | CACHD1_2 | 288_WHI-P97_3 / 263_FR-180204_3 / 344_THZ-2-49_3 | other / erk_mapk / cell_cyc | 1_26457907_T_G / 2_119366546_A_G |
| 185 | VPS37D_2 | 226_GSK1070916_2 / 305_TPCA-1_3 / 303_PIK-93_3 | mitosis / other / pi3k | 7_72941936_T_C / 1_26457907_T_G |
| 186 | ZDHHC17_1 | 226_GSK1070916_2 / 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / mitosis / erk_mapk | 1_26457907_T_G |
| 187 | TMEM9B_2 | 228_AKT_inhibitor_VIII_3 / 281_Alectinib_2 / 263_FR-180204_3 | pi3k / rtk / erk_mapk | 1_26457907_T_G / 11_120298301_A_C |
| 188 | HOXD10_1 | 344_THZ-2-49_3 / 298_OSI-930_2 / 310_YM201636_3 | cell_cyc / rtk / other | 1_26457907_T_G |
| 189 | ITFG2_1 | 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 / 326_GSK690693_3 | rtk / pi3k / pi3k | 1_26457907_T_G |
| 190 | EGFL7_1 | 263_FR-180204_3 / 271_VNLG/124_3 / 185_Linsitinib_2 | erk_mapk / chromatin / igfr | 22_22643666_C_G |
| 191 | PPP2R2A_5 | 310_YM201636_3 / 263_FR-180204_3 / 326_GSK690693_3 | other / erk_mapk / pi3k | 13_20189082_A_C / 12_52771095_C_G / 1_26457907_T_G / 3_126068075_T_G / 22_21127217_C_G |
| 192 | BRF2_2 | 263_FR-180204_3 / 326_GSK690693_3 / 294_MPS-1-IN-1_3 | erk_mapk / pi3k / mitosis | 22_21283300_G_C / 7_37907554_A_G |
| 193 | ATP1B2_1 | 294_MPS-1-IN-1_3 / 310_YM201636_3 / 290_KIN001-260_3 | mitosis / other / other | 16_3027533_A_G |
| 194 | PTGES3_2 | 281_Alectinib_2 / 273_CUDC-101_2 / 228_AKT_inhibitor_VIII_3 | rtk / chromatin / pi3k | 1_26457907_T_G / 1_149813302_A_C |
| 195 | NR0B1_2 | 1259_Talazoparib_3 / 344_THZ-2-49_3 / 310_YM201636_3 | g_integrity / cell_cyc / other | 1_26457907_T_G / 22_21127217_C_G |
| 196 | GALNT10_2 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk | 13_99295007_C_T / 13_99314037_A_G |
| 197 | TMEM229A_1 | 263_FR-180204_3 / 1011_Navitoclax_2 / 310_YM201636_3 | erk_mapk / apop / other | 22_22643666_C_G |
| 198 | NCEH1_1 | 263_FR-180204_3 / 185_Linsitinib_2 / 228_AKT_inhibitor_VIII_3 | erk_mapk / igfr / pi3k | 6_151015603_C_G |
| 199 | C1orf27_1 | 263_FR-180204_3 / 344_THZ-2-49_3 / 310_YM201636_3 | erk_mapk / cell_cyc / other | 15_25177023_G_C |
| 200 | TMEM14C_1 | 228_AKT_inhibitor_VIII_3 / 263_FR-180204_3 / 310_YM201636_3 | pi3k / erk_mapk / other | 6_31662464_C_T |
| 201 | DKK3_1 | 1526_Refametinib_3 / 1372_Trametinib_1 / 1014_Refametinib_2 | erk_mapk / erk_mapk / erk_mapk | 11_24729296_G_A |
| 202 | LRRC4C_1 | 263_FR-180204_3 / 344_THZ-2-49_3 / 252_WZ3105_3 | erk_mapk / cell_cyc / other | 12_52771095_C_G |
| 203 | HOXD9_1 | 263_FR-180204_3 / 344_THZ-2-49_3 / 136_Mitomycin-C_1 | erk_mapk / cell_cyc / DNArep | 5_140829601_T_G |
| 204 | SLC5A6_2 | 263_FR-180204_3 / 221_TAK-715_2 / 228_AKT_inhibitor_VIII_3 | erk_mapk / jnk_p38 / pi3k | 1_184808038_A_C / X_46860063_C_T |
| 205 | LYPD1_1 | 274_Belinostat_1 / 273_CUDC-101_2 / 276_CAY10603_3 | chromatin / chromatin / chromatin | 1_129285_G_A |
| 206 | CIB1_1 | 263_FR-180204_3 / 226_GSK1070916_2 / 305_TPCA-1_3 | erk_mapk / mitosis / other | 15_25177023_G_C |
| 207 | PDSS1_2 | 263_FR-180204_3 / 1008_Methotrexate_1 / 288_WHI-P97_3 | erk_mapk / DNArep / other | 15_89633846_A_C / 22_39376109_T_G |
| 208 | SHC2_1 | 326_GSK690693_3 / 263_FR-180204_3 / 310_YM201636_3 | pi3k / erk_mapk / other | 19_54631904_A_C |
| 209 | ATP6V0B_1 | 1060_PD0325901_2 / 1372_Trametinib_1 / 1498_Selumetinib_2 | erk_mapk / erk_mapk / erk_mapk | 1_9850602_T_G |
| 210 | SEPSECS_1 | 341_Selisistat_3 / 286_KIN001-236_3 / 1008_Methotrexate_1 | other / other / DNArep | 2_28529292_G_T |
| 211 | BHLHE22_2 | 310_YM201636_3 / 263_FR-180204_3 | other / erk_mapk | 1_26457907_T_G / 22_21127217_C_G |
| 212 | FOXC1_1 | 263_FR-180204_3 / 310_YM201636_3 | erk_mapk / other | 1_26457907_T_G |
| 213 | DMRTA1_1 | 290_KIN001-260_3 / 286_KIN001-236_3 | other / other | 7_72949311_A_C |
| 214 | CRYBG3_2 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 | erk_mapk / mitosis | 22_21127217_C_G / 1_149813302_A_C |
| 215 | ANKRD28_1 | 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 | erk_mapk / pi3k | 1_26457907_T_G |
| 216 | ZNF467_3 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / erk_mapk | 17_78120770_A_C / 22_21283300_G_C / 5_157491842_C_T |
| 217 | MCU_1 | 281_Alectinib_2 / 344_THZ-2-49_3 | rtk / cell_cyc | 1_26457907_T_G |
| 218 | ALG6_1 | 281_Alectinib_2 / 294_MPS-1-IN-1_3 | rtk / mitosis | 1_26457907_T_G |
| 219 | DST_1 | 263_FR-180204_3 / 185_Linsitinib_2 | erk_mapk / igfr | 22_22643666_C_G |
| 220 | CNOT6_1 | 263_FR-180204_3 / 294_MPS-1-IN-1_3 | erk_mapk / mitosis | 22_22643666_C_G |
| 221 | SLC25A46_1 | 283_Omipalisib_2 / 228_AKT_inhibitor_VIII_3 | pi3k / pi3k | 22_22643666_C_G |
| 222 | STRBP_3 | 263_FR-180204_3 / 1259_Talazoparib_3 | erk_mapk / g_integrity | 22_22643666_C_G / 16_55810697_G_T / 22_21127217_C_G |
| 223 | SLFN11_1 | 263_FR-180204_3 / 344_THZ-2-49_3 | erk_mapk / cell_cyc | 15_25177023_G_C |
| 224 | IL1R1_1 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / erk_mapk | 11_66624536_A_C |
| 225 | PDE9A_2 | 271_VNLG/124_3 / 263_FR-180204_3 | chromatin / erk_mapk | 19_5654163_A_C / 22_19918884_A_C |
| 226 | TXNDC11_1 | 1011_Navitoclax_2 / 344_THZ-2-49_3 | apop / cell_cyc | 19_624780_A_G |
| 227 | NRP1_2 | 1526_Refametinib_3 / 1014_Refametinib_2 | erk_mapk / erk_mapk | 3_180647255_T_TA / 15_68718780_C_T |
| 228 | QSER1_1 | 344_THZ-2-49_3 / 310_YM201636_3 | cell_cyc / other | 6_31464043_C_T |
| 229 | TNIP1_1 | 1526_Refametinib_3 / 154_CHIR-99021_3 | erk_mapk / wnt | 3_180647255_T_TA |
| 230 | LIMS1_1 | 1372_Trametinib_1 / 1526_Refametinib_3 | erk_mapk / erk_mapk | 8_138630731_T_C |
| 231 | PNISR_1 | 265_Tubastatin A_3 / 292_Masitinib_1 | chromatin / rtk | 15_42142087_A_C |
| 232 | MOAP1_1 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / erk_mapk | 20_53576113_T_G |
| 233 | KAT2B_3 | 228_AKT_inhibitor_VIII_3 / 294_MPS-1-IN-1_3 | pi3k / mitosis | 19_17618978_T_G / 19_17618863_T_TG / 22_22643666_C_G |
| 234 | NBAS_2 | 292_Masitinib_1 / 286_KIN001-236_3 | rtk / other | 1_182843301_T_G / 2_112783793_A_C |
| 235 | RPAP3_1 | 281_Alectinib_2 / 310_YM201636_3 | rtk / other | 16_3027533_A_G |
| 236 | PCDH8_1 | 263_FR-180204_3 / 310_YM201636_3 | erk_mapk / other | 12_52771095_C_G |
| 237 | NRTN_1 | 185_Linsitinib_2 / 294_MPS-1-IN-1_3 | igfr / mitosis | 1_149813302_A_C |
| 238 | NFE2L3_3 | 1242_(5Z)-7-Oxozeaenol_3 / 1014_Refametinib_2 | other / erk_mapk | 22_32394994_C_G / X_119791251_A_C / 5_113434330_T_G |
| 239 | AXL_2 | 1526_Refametinib_3 / 1372_Trametinib_1 | erk_mapk / erk_mapk | 4_42616004_T_TA / 4_42616121_A_G |
| 240 | FAM84B_1 | 263_FR-180204_3 / 344_THZ-2-49_3 | erk_mapk / cell_cyc | 13_24951498_G_C |
| 241 | SERPING1_2 | 263_FR-180204_3 / 228_AKT_inhibitor_VIII_3 | erk_mapk / pi3k | 19_4930892_T_G / 1_151048750_A_C |
| 242 | MAN2A2_1 | 294_MPS-1-IN-1_3 / 263_FR-180204_3 | mitosis / erk_mapk | 18_112338_G_A |
| 243 | PPP1R1B_2 | 1015_CI-1040_2 / 1062_Selumetinib_2 | erk_mapk / erk_mapk | 6_53899709_T_G / 7_99012221_A_C |
| 244 | LIM2_1 | 211_TL-2-105_3 / 345_KIN001-270_3 | erk_mapk / cell_cyc | 1_193249713_C_G |
| 245 | ENC1_1 | 1526_Refametinib_3 / 1372_Trametinib_1 | erk_mapk / erk_mapk | 15_69422319_A_C |
| 246 | TXNDC15_1 | 281_Alectinib_2 / 228_AKT_inhibitor_VIII_3 | rtk / pi3k | 12_121016539_T_A |
| 247 | CTGF_1 | 1372_Trametinib_1 / 1498_Selumetinib_2 | erk_mapk / erk_mapk | 10_99533046_A_G |
| 248 | EGFLAM_2 | 281_Alectinib_2 / 252_WZ3105_3 | rtk / other | 2_217818534_A_G / 2_217817751_A_G |
| 249 | ARHGAP10_2 | 263_FR-180204_3 | erk_mapk | 22_22643666_C_G / 1_26457907_T_G |
| 250 | EBF3_1 | 344_THZ-2-49_3 | cell_cyc | 1_26457907_T_G |
| 251 | PLAGL2_1 | 263_FR-180204_3 | erk_mapk | 1_26457907_T_G |
| 252 | XKR4_3 | 263_FR-180204_3 | erk_mapk | 1_26457907_T_G / 12_52771095_C_G / 22_21127217_C_G |
| 253 | HR_1 | 288_WHI-P97_3 | other | 1_26457907_T_G |
| 254 | GLB1L2_1 | 263_FR-180204_3 | erk_mapk | 22_22643666_C_G |
| 255 | GOLIM4_1 | 263_FR-180204_3 | erk_mapk | 22_22643666_C_G |
| 256 | TMEM127_1 | 263_FR-180204_3 | erk_mapk | 22_22643666_C_G |
| 257 | USP21_1 | 263_FR-180204_3 | erk_mapk | 22_22643666_C_G |
| 258 | FAIM_5 | 344_THZ-2-49_3 | cell_cyc | 5_141432375_A_C / 1_26457907_T_G / 17_49252681_A_C / 10_122983276_G_A / 15_84654249_A_C |
| 259 | COX19_2 | 326_GSK690693_3 | pi3k | 22_24658344_C_G / 1_26457907_T_G |
| 260 | LRP10_3 | 344_THZ-2-49_3 | cell_cyc | 1_26457907_T_G / 12_52771095_C_G / 22_22643666_C_G |
| 261 | ASPH_1 | 1526_Refametinib_3 | erk_mapk | 3_180647255_T_TA |
| 262 | CASP4_1 | 1526_Refametinib_3 | erk_mapk | 3_180647255_T_TA |
| 263 | PPFIBP1_1 | 1526_Refametinib_3 | erk_mapk | 3_180647255_T_TA |
| 264 | PRRX2_1 | 1526_Refametinib_3 | erk_mapk | 3_180647255_T_TA |
| 265 | TADA1_1 | 1526_Refametinib_3 | erk_mapk | 3_180647255_T_TA |
| 266 | FBXO15_2 | 288_WHI-P97_3 | other | 22_22643666_C_G / 22_21127217_C_G |
| 267 | RPRD1A_3 | 263_FR-180204_3 | erk_mapk | 15_23364657_T_G / 4_190079171_C_T / 15_64381446_G_A |
| 268 | HS3ST3B1_2 | 273_CUDC-101_2 | chromatin | 15_42142087_A_C / 5_141432375_A_C |
| 269 | RBM39_1 | 286_KIN001-236_3 | other | 1_26457907_T_G |
| 270 | MRPS34_1 | 1014_Refametinib_2 | erk_mapk | 3_180647255_T_TA |
| 271 | PPARD_1 | 263_FR-180204_3 | erk_mapk | 15_25177023_G_C |
| 272 | TRIM29_2 | 1142_HG-5-113-01_2 | abl | 12_94248247_C_T / 15_50747694_T_C |
| 273 | SLITRK3_2 | 310_YM201636_3 | other | 12_52771095_C_G / 1_26457907_T_G |
| 274 | AOX1_1 | 185_Linsitinib_2 | igfr | 6_151015603_C_G |
| 275 | WDR41_1 | 281_Alectinib_2 | rtk | 2_217818534_A_G |
| 276 | WDR60_1 | 283_Omipalisib_2 | pi3k | 1_26457907_T_G |
| 277 | ELOVL1_1 | 136_Mitomycin-C_1 | DNArep | 22_24252424_G_C |
| 278 | ISYNA1_1 | 263_FR-180204_3 | erk_mapk | 8_22080213_T_C |
| 279 | BTBD17_1 | 281_Alectinib_2 | rtk | 1_26457907_T_G |
| 280 | E2F6_1 | 281_Alectinib_2 | rtk | 1_26457907_T_G |
| 281 | REEP5_1 | 281_Alectinib_2 | rtk | 1_26457907_T_G |
| 282 | HIF3A_2 | 228_AKT_inhibitor_VIII_3 | pi3k | 1_26457907_T_G / 16_3027533_A_G |
| 283 | PLIN3_1 | 1526_Refametinib_3 | erk_mapk | 10_92024747_C_T |
| 284 | SLC25A43_1 | 1526_Refametinib_3 | erk_mapk | 10_92024747_C_T |
| 285 | NINL_2 | 185_Linsitinib_2 | igfr | 22_22643666_C_G / 1_26457907_T_G |
| 286 | ZNF232_2 | 281_Alectinib_2 | rtk | 5_141432375_A_C / 6_32040790_G_C |
| 287 | SIRT4_5 | 226_GSK1070916_2 | mitosis | 19_32862451_C_T / 19_32864163_A_G / 1_26457907_T_G / 15_89806436_T_G / 11_120298301_A_C |
| 288 | TP53BP2_1 | 228_AKT_inhibitor_VIII_3 | pi3k | 22_21127217_C_G |
| 289 | DLGAP1_1 | 263_FR-180204_3 | erk_mapk | 22_21127217_C_G |
| 290 | ELL2_1 | 228_AKT_inhibitor_VIII_3 | pi3k | 22_22643666_C_G |
| 291 | L3MBTL1_1 | 300_CX-5461_3 | other | 8_22080213_T_C |
| 292 | VCL_1 | 281_Alectinib_2 | rtk | 5_141432375_A_C |
| 293 | FOXN4_1 | 211_TL-2-105_3 | erk_mapk | 19_12391643_A_G |
| 294 | DGKD_2 | 288_WHI-P97_3 | other | 22_24252424_G_C / 11_62825464_G_C |
| 295 | UHMK1_2 | 344_THZ-2-49_3 | cell_cyc | 6_31710251_C_T / 6_31464043_C_T |
| 296 | ATG10_1 | 1091_BMS-536924_3 | igfr | 3_120173274_C_G |
| 297 | RTN4_1 | 1526_Refametinib_3 | erk_mapk | 2_87800520_G_A |
| 298 | ZBTB34_2 | 1091_BMS-536924_3 | igfr | 11_1244522_A_C / 6_151015603_C_G |
| 299 | TRAPPC1_1 | 1011_Navitoclax_2 | apop | 16_18896782_A_AAT |
| 300 | MAN1A1_1 | 263_FR-180204_3 | erk_mapk | 11_61744427_A_C |
| 301 | GPR155_1 | 281_Alectinib_2 | rtk | 22_22643666_C_G |
| 302 | NUP205_1 | 226_GSK1070916_2 | mitosis | 17_7604041_A_C |
| 303 | DFNA5_1 | 1526_Refametinib_3 | erk_mapk | 11_24729296_G_A |
| 304 | ESYT2_1 | 263_FR-180204_3 | erk_mapk | 2_119366546_A_G |
| 305 | ARRDC5_1 | 1067_CCT007093_3 | other | 1_112653574_TA_T |
| 306 | WWOX_1 | 185_Linsitinib_2 | igfr | 22_21127217_C_G |
| 307 | TTC12_1 | 344_THZ-2-49_3 | cell_cyc | 11_1246619_A_C |
| 308 | PHLDA1_1 | 263_FR-180204_3 | erk_mapk | 6_151015603_C_G |
| 309 | USP44_2 | 1526_Refametinib_3 | erk_mapk | 7_155711220_A_C / 15_69422319_A_C |
| 310 | PLTP_1 | 341_Selisistat_3 | other | 1_176800222_T_C |
| 311 | FOXK2_2 | 1526_Refametinib_3 | erk_mapk | 17_57105517_C_T / 17_57110197_C_G |
| 312 | ERRFI1_1 | 1372_Trametinib_1 | erk_mapk | 17_41820457_A_C |
| 313 | NCAPG2_2 | 1378_Bleomycin(50uM)_1 | DNArep | 17_40554659_A_G / 6_146599135_C_T |
| 314 | GNG12_2 | 1526_Refametinib_3 | erk_mapk | 4_42616004_T_TA / 4_42616121_A_G |
| 315 | GTF2IRD1_2 | 185_Linsitinib_2 | igfr | 13_99295924_C_A / 16_4823959_A_C |
| 316 | CDH13_1 | 1526_Refametinib_3 | erk_mapk | 8_108228165_T_G |
| 317 | USPL1_1 | 1218_JQ1_3 | chromatin | 11_117206249_T_G |
| 318 | C8orf33_2 | 226_GSK1070916_2 | mitosis | 1_152805392_A_G / 1_152805488_G_A |
| 319 | LARP4_1 | 344_THZ-2-49_3 | cell_cyc | 19_21767500_C_T |
| 320 | WISP2_3 | 291_KIN001-266_3 | other | 15_34382849_C_T / 15_34382220_G_A / 15_34528441_G_A |
| 321 | ACTR3B_1 | 226_GSK1070916_2 | mitosis | 19_5680513_A_C |
| 322 | CACNA1H_1 | 1091_BMS-536924_3 | igfr | 1_26457907_T_G |
| 323 | KIT_5 | 1526_Refametinib_3 | erk_mapk | 19_55181918_C_T / 19_55185911_C_T / 19_55186384_AG_A / 19_55186398_T_A / 19_55186427_G_C |
| 324 | PFKFB4_1 | 1259_Talazoparib_3 | g_integrity | 2_48582490_G_T |
| 325 | PRKCA_1 | 226_GSK1070916_2 | mitosis | 14_39074610_T_TAAG |
| 326 | PPIB_1 | 310_YM201636_3 | other | 12_31206191_C_T |
| 327 | GUK1_1 | 1239_YK-4-279_3 | other | 3_184849291_A_T |
| 328 | TOMM20_1 | 263_FR-180204_3 | erk_mapk | 6_33315732_A_C |
| 329 | MCFD2_1 | 1526_Refametinib_3 | erk_mapk | 7_102356028_T_G |
| 330 | ARL2BP_1 | 1262_UNC1215_3 | other | 10_17122761_A_AC |
| 331 | DSTN_2 | 51_Dasatinib_1 | abl | 16_24750598_A_G / 16_24806184_C_T |
| No. | FRH | Var_Exp(pval) | Var_Drug(pval) | Exp_Drug(pval) | Ave_VarDrug(pval) | Rank |
| 1 | LUC7L_5 | 1.15E-13 | 1.91E-09 / 4.67E-09 / 2.52E-08 / 4.96E-08 / 6.43E-08 / 1.09E-07 / 5.42E-07 / 5.69E-07 / 6.37E-07 / 6.61E-07 / 7.24E-07 / 8.41E-07 / 9.74E-07 / 1.12E-06 / 1.30E-06 / 1.85E-06 / 2.11E-06 / 2.61E-06 / 4.14E-06 / 4.58E-06 / 4.71E-06 / 5.01E-06 / 6.19E-06 / 6.58E-06 / 8.57E-06 / 1.05E-05 / 1.13E-05 / 1.15E-05 / 1.30E-05 / 1.46E-05 / 1.53E-05 / 1.53E-05 / 1.59E-05 / 1.84E-05 / 2.07E-05 / 2.21E-05 / 2.43E-05 / 2.46E-05 / 2.89E-05 / 3.30E-05 / 3.88E-05 / 4.17E-05 / 4.23E-05 / 4.72E-05 / 6.02E-05 / 7.09E-05 / 7.70E-05 / 8.39E-05 / 8.89E-05 / 9.55E-05 / 0.000109598 / 0.000148946 / 0.000152384 / 0.000155038 / 0.000170866 / 0.000172159 / 0.000191632 / 0.000193261 / 0.000195059 / 0.000248358 / 0.000327687 / 0.000332153 / 0.000349439 / 0.000359765 / 0.00043352 / 0.000523494 / 0.000575856 / 0.00059693 / 0.000653659 / 0.000706716 / 0.00085491 / 0.000864851 / 0.001002398 / 0.00117613 / 0.001408554 / 0.001650567 / 0.001984983 / 0.002024319 / 0.00212417 / 0.002216293 / 0.002233734 / 0.002266673 / 0.002284694 / 0.002445929 / 0.002559027 / 0.002603948 / 0.002721712 / 0.002828387 / 0.003047476 / 0.003355885 / 0.004005854 / 0.004439654 / 0.004491468 / 0.004552462 / 0.005010534 / 0.00514149 / 0.005153885 / 0.005246181 / 0.005770832 / 0.005771327 / 0.006149164 / 0.00699638 / 0.007479033 / 0.009163032 / 0.009744318 | 9.24E-10 / 7.33E-07 / 1.80E-06 / 5.58E-07 / 5.49E-06 / 8.00E-06 / 1.11E-05 / 3.59E-05 / 2.57E-05 / 1.51E-05 / 0.000278643 / 1.29E-05 / 4.04E-05 / 4.27E-07 / 6.04E-05 / 1.36E-05 / 0.00095004 / 0.000354468 / 7.37E-05 / 0.000178107 / 1.81E-05 / 9.92E-06 / 2.90E-05 / 7.60E-05 / 0.000108534 / 5.28E-06 / 0.000909895 / 0.0001216 / 3.90E-05 / 8.71E-05 / 0.000177412 / 0.000229785 / 0.000206397 / 0.001303165 / 0.000336718 / 0.000220325 / 0.000794135 / 0.005242396 / 0.000138311 / 0.00012461 / 0.002555093 / 3.34E-05 / 0.000212185 / 0.000235135 / 0.003059306 / 0.002031234 / 4.10E-05 / 0.002839464 / 0.001941941 / 0.002111014 / 0.003734935 / 0.00088133 / 0.000260418 / 0.000159567 / 0.000217979 / 0.003045665 / 0.000711377 / 0.004950231 / 0.000568103 / 0.003370008 / 0.000210216 / 0.001266072 / 0.000968439 / 0.00032227 / 0.0047926 / 0.000154025 / 0.000752605 / 0.00142213 / 0.001031722 / 0.001286562 / 0.002164935 / 0.0003112 / 0.002677139 / 0.018218112 / 0.002277549 / 0.109175833 / 0.016662693 / 0.019365546 / 0.002033578 / 0.003027991 / 0.006961933 / 0.025514886 / 0.024966968 / 0.005997059 / 0.001981323 / 0.029427464 / 0.012944297 / 0.01786683 / 0.037151491 / 0.001073091 / 0.000598838 / 0.061847574 / 0.007922021 / 0.022872712 / 0.059848402 / 0.01228946 / 0.01332271 / 0.002004364 / 0.02173673 / 0.012503551 / 0.025681208 / 0.001105028 / 0.008624497 / 0.010968462 / 0.004721309 | 1.32E-03 | 105 |
| 2 | FZD3_1 | 0.0000000028 | 2.0071481202007584e-05 / 1.3062838211579366e-05 / 0.00029640089162746337 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 4.559947241482223e-05 / 0.0003167991900078877 / 0.005510243055764825 / 2.4023375765700413e-05 / 0.0019333915490623197 / 3.2501044823812903e-07 / 5.2109649171464235e-06 / 0.0005120167928359619 / 0.0005120167928359619 / 5.1570472200670454e-05 / 5.2109649171464235e-06 / 0.0006200425273220967 / 1.615375160694009e-05 / 0.002238680629992204 / 0.0004073113752386311 / 0.004583801528895219 / 3.1219185299958266e-05 / 0.0002809149065890676 / 0.00043137964232097263 / 0.0011323441860117745 / 0.0005820808941317769 / 0.0004771627200779347 / 0.001077781567228248 / 0.005510243055764825 / 4.0242980256377906e-05 / 0.0014854545690578267 / 5.831891151164244e-05 / 0.001178242777327155 / 8.058554843717415e-06 / 6.979794879972793e-06 / 0.03195616924078522 / 3.54688199707126e-05 / 0.0004422271229621968 / 0.016412811603890378 / 9.224071980226081e-07 / 0.003763661611010697 / 0.005510243055764825 / 0.0019333915490623197 | 4.399804084045925e-11 / 4.8538578704375377e-11 / 5.819712693031694e-10 / 2.963122656898289e-09 / 4.44134906876112e-09 / 1.7977709248154422e-08 / 9.42533011316618e-09 / 1.1148075349332164e-08 / 9.89017118210351e-09 / 2.8769458288469503e-08 / 8.244633671431711e-10 / 5.45137061905865e-09 / 1.8398488800553676e-08 / 1.804720713536623e-08 / 3.173412287913158e-08 / 9.525086920943969e-09 / 8.7889354451487e-09 / 4.116637231593234e-09 / 2.9588878898633333e-08 / 4.0650948961653235e-08 / 2.8027611743995904e-07 / 6.8134604562299e-07 / 2.1399314856199655e-07 / 5.167422923449075e-08 / 5.613208935352902e-08 / 7.672478617521056e-07 / 1.6315736932712637e-07 / 2.4166361947108844e-07 / 1.451917420035471e-08 / 7.300226960704237e-07 / 1.5352094129494146e-07 / 1.2282012910353222e-06 / 3.875740564606093e-08 / 1.0494748900823875e-07 / 6.763565198781288e-08 / 5.748334030450384e-07 / 3.353627284114995e-06 / 4.936480143362891e-06 / 2.623117317143412e-06 / 5.626937405898294e-07 / 4.3859213486095075e-05 / 5.694315703855324e-08 / 1.2859395153980585e-05 / 5.4888376565657605e-06 / 2.7878746100826557e-05 | 0.001989712 | 45 |
| 3 | LMBR1L_3 | 0.0000000000 | 1.3115991775009544e-05 / 4.285325077077582e-05 / 2.6206760013115565e-05 / 8.940710288311502e-06 / 0.00023367518351846944 / 0.00013454362830845267 / 2.7344476741525248e-06 / 0.00015924703665692674 / 5.3436977682081055e-06 / 0.001425251066430146 / 7.290937080786633e-06 / 0.00014505690669972785 / 0.002708575118877282 / 0.0005354820201602493 / 0.0001891558085520366 / 0.0003390052340801507 / 0.00018791070326594343 / 5.476715755935002e-05 / 0.0006679513440066498 / 0.00027536436395942185 / 0.0007522453642716858 / 0.0004227612426053383 / 0.0006897961607062659 / 0.004578099476046143 / 9.144525988487157e-05 / 0.0002954537200985898 / 0.0003409317530540561 / 0.00022273590395933135 / 9.752428481242424e-05 / 2.7031767322445152e-06 / 0.0025088064616324564 / 0.0017094647117891196 / 0.0002960302092991554 / 0.001425251066430146 | 2.4878867617785033e-08 / 5.567969153038763e-09 / 2.2333257462478582e-06 / 1.5621435413932192e-07 / 8.122287757832368e-07 / 1.1594398210650143e-07 / 2.9535242848860537e-07 / 2.5457580110872606e-07 / 1.1054851619419285e-06 / 3.6946271417190457e-06 / 7.434545034394883e-08 / 4.865301638318462e-07 / 7.955105981028123e-06 / 1.7636078112442492e-06 / 3.8772692803359075e-06 / 4.71942956895538e-06 / 7.710653232292368e-07 / 9.824959916701546e-06 / 2.626863984658229e-06 / 1.4275291126372483e-06 / 5.610135612369372e-06 / 1.985624144436174e-06 / 5.224149339178947e-06 / 1.1780186697477374e-05 / 9.265182617395918e-07 / 7.64885082423866e-07 / 2.3462097383522345e-06 / 7.599816951433106e-06 / 9.768824284806429e-06 / 1.3141060307652716e-05 / 3.191552185410624e-05 / 8.929464106552106e-06 / 2.387431583758606e-06 / 9.679020756011901e-06 | 0.000605756 | 34 |
| 4 | ACTN2_3 | 0.0000000000 | 1.6547061876174137e-09 / 7.813308929582946e-09 / 1.3841014381780992e-08 / 7.203525855071736e-08 / 1.8450442549499973e-07 / 3.911794473620475e-08 / 1.4114679221229936e-07 / 0.00012290638155137984 / 3.925563562928499e-06 / 7.3416069286602765e-06 / 3.606677790993339e-06 / 1.4592559377242048e-06 / 3.2260283767681983e-07 / 1.193290985948489e-06 / 3.129728827401602e-07 / 5.1156576790479636e-06 / 2.2015209230331294e-05 / 9.735933136603846e-06 / 3.163985594214517e-06 / 3.935050666499894e-05 / 1.4266019809199946e-07 / 1.545453068208723e-06 / 4.094608902301485e-06 / 6.287076933306607e-05 / 8.143883852558403e-05 / 1.7745606348891978e-05 / 1.9064246508411654e-05 / 3.914526751739124e-06 / 0.0008320152992610897 / 0.00014766547542325887 / 1.0608918025365037e-05 / 1.3327004931767278e-05 / 3.456388577880954e-06 | 8.346739914919394e-10 / 2.6568139110468435e-10 / 1.4297929266679253e-08 / 1.407569556254511e-08 / 7.425827856215124e-09 / 6.044864807461728e-07 / 4.09575569135761e-08 / 2.5796549872310057e-06 / 9.727443509821518e-06 / 2.0346517301279246e-06 / 1.821337487108634e-07 / 1.1858667937809359e-06 / 3.0908955186716785e-06 / 3.9399829491464125e-06 / 7.557297698538621e-07 / 1.0224109644328716e-05 / 9.68241332215864e-06 / 5.610135612369372e-06 / 7.333671574889317e-06 / 1.6079955555468178e-06 / 1.0121247355306893e-06 / 4.744377470169944e-06 / 4.290604050280735e-06 / 4.1558712164911445e-06 / 4.452894368538964e-06 / 3.298618443622974e-05 / 5.383699135825628e-06 / 5.133532807266582e-06 / 7.79534870420108e-06 / 8.49542319812634e-06 / 7.898719458534555e-06 / 4.382658462880079e-06 / 1.2453763214764084e-05 | 4.29939E-05 | 33 |
| 5 | UBXN7_2 | 0.0000000085 | 1.2294933823319138e-07 / 0.0009528394445576896 / 2.5977106349140097e-07 / 4.438966867654239e-06 / 4.175847453807821e-05 / 2.2989177020843574e-05 / 1.0258657437467221e-05 / 6.35563211244946e-07 / 9.34271970438383e-06 / 0.00012842370411037036 / 0.00038022299535494034 / 4.732975057010584e-06 / 6.0398819534333666e-05 / 0.0008312382650131915 / 7.10198962884777e-05 / 0.000737382769650959 / 0.00010754182303257409 / 0.0008657599149476789 / 2.064971477980467e-05 / 0.0021438374376241726 / 0.00011799868875755327 / 6.713449614052975e-05 / 9.23837432003526e-05 / 0.006927717611275514 / 9.323186511449603e-05 / 6.344424772676006e-05 / 7.202281209470204e-05 / 0.0016679197649297247 / 0.0007630126686111583 / 0.00014077366120352972 / 0.0011908689867155006 / 0.00014493182389933843 / 5.074180415291073e-06 | 1.3148237968215948e-08 / 1.0058181189300685e-08 / 2.866158880903668e-07 / 3.321317019211789e-07 / 2.534746351463287e-07 / 6.649001393280087e-07 / 2.0062892730841753e-06 / 3.0760538337201583e-07 / 1.0537432811773585e-06 / 8.286284914667759e-07 / 2.5056723004222252e-05 / 1.1607897314120808e-06 / 3.6896905862079686e-06 / 2.3529977016400513e-05 / 4.07908271138199e-05 / 2.233895897066247e-05 / 3.9901071706105935e-06 / 9.246191514674586e-06 / 2.970908809716153e-05 / 1.3864656266823086e-05 / 2.7158231870787934e-06 / 2.8767737648395844e-06 / 0.00018285226698360374 / 3.2329494806633123e-06 / 4.56486535636156e-06 / 4.367493381976092e-06 / 2.3915904995124888e-05 / 4.7400303970179404e-05 / 5.693865725616807e-06 / 1.5212355293442166e-06 / 1.4981327208193748e-05 / 1.901917225424515e-05 / 9.246191514674586e-06 | 0.000537587 | 33 |
| 6 | TRAM2_2 | 0.0000000000 | 3.4192931304829014e-06 / 1.3401582342156554e-08 / 4.659755401849588e-08 / 3.633081984870721e-07 / 5.207246052888057e-07 / 1.892412103400743e-05 / 1.3942380334535833e-06 / 2.0535846739106096e-05 / 7.359704703027111e-07 / 2.225580423517811e-06 / 5.5806145526532266e-05 / 4.592877446409494e-06 / 4.592877446409494e-06 / 1.8937125547570738e-05 / 0.00021267966425080588 / 0.00095500393558891 / 1.6992771909182382e-05 / 5.326859676055172e-06 / 0.00020111609082546164 / 5.84826493375201e-05 / 1.096889887353167e-06 / 4.05395891219117e-07 / 4.835640776889601e-06 / 1.017482106342708e-05 / 0.00036820277558262876 / 2.3498756278510995e-06 / 6.031057779485052e-06 / 4.602166722353917e-05 / 4.77141612260032e-05 / 7.647399823593637e-05 / 1.3010063548672435e-05 / 5.700938644514364e-06 | 4.322589807838839e-10 / 1.0710488778074884e-09 / 2.2541585510298175e-09 / 1.567254897199143e-09 / 5.8397941769315956e-08 / 1.0411408006909947e-07 / 1.5621435413932192e-07 / 2.6273639848288776e-07 / 7.180942105428594e-08 / 2.841652507631913e-07 / 1.75722450249221e-07 / 5.273247808971176e-07 / 2.5292802828220107e-07 / 3.6227709430270065e-07 / 3.9578672189598e-07 / 7.272069346106795e-06 / 3.1693546387669756e-07 / 8.122287757832368e-07 / 6.365489980748545e-07 / 7.244824414060728e-07 / 5.5398839416627e-07 / 2.1048201026388255e-08 / 4.694603023798112e-06 / 1.2067933247814594e-06 / 1.9510165024642392e-06 / 1.228062366600316e-06 / 3.739290293217579e-07 / 2.595574803350586e-06 / 7.308783057822739e-06 / 3.561518617190357e-08 / 4.694603023798112e-06 / 1.9523949703929863e-06 | 6.76165E-05 | 32 |
| 7 | CDK13_2 | 0.0000000046 | 1.3853996990825065e-07 / 5.7745918340825286e-08 / 1.047470062062923e-07 / 3.956087072154918e-06 / 4.7520049447710837e-07 / 8.531496260442106e-08 / 7.3804316374052654e-06 / 4.47869272440367e-06 / 1.3463919058643852e-06 / 1.280613569121123e-06 / 3.6878940499153197e-07 / 0.00016082587811719362 / 0.00011322141355414124 / 0.0008207792485387008 / 0.0012079337533688077 / 2.9520572987073497e-05 / 1.140318186185745e-06 / 7.232001821345798e-06 / 8.539102875978968e-07 / 4.4499857317195853e-07 / 1.6907634798991045e-06 / 1.436764278578512e-05 / 3.9201554157572025e-06 / 0.00015124776392064736 / 8.137865842046858e-07 / 8.776477751355082e-06 / 7.3804316374052654e-06 / 2.5501614319254746e-05 / 6.930572497830363e-05 / 9.349083309404483e-05 / 3.4999466370498394e-05 / 8.383566724982507e-05 | 8.041496040856773e-10 / 1.1212152252396135e-09 / 2.2149509398591615e-09 / 6.49921859944133e-08 / 1.146609360749861e-08 / 9.315547292848514e-09 / 7.076208121664563e-08 / 1.5105555334027616e-07 / 1.4275728512486712e-07 / 3.3998096773618356e-07 / 1.7384894474420941e-07 / 1.7501056125582978e-07 / 1.6481167858879217e-07 / 7.741434363358432e-07 / 1.5033075637026901e-06 / 2.258352385302198e-06 / 1.0175118608827892e-07 / 1.054741547163592e-06 / 7.695013127009913e-07 / 7.954172678849231e-07 / 1.1584887732120262e-06 / 1.8682249268554782e-07 / 4.110133905921353e-07 / 2.4667255985252546e-05 / 5.724946196061661e-07 / 4.748434316553696e-06 / 6.535278991184282e-07 / 1.477642900652424e-06 / 3.526294982097946e-06 / 5.176376148472376e-07 / 2.387431583758606e-06 / 2.412245892896333e-05 | 8.92798E-05 | 32 |
| 8 | BCL11B_3 | 0.0000000011 | 2.1691780926743226e-07 / 8.225833660011401e-07 / 1.789237622088428e-06 / 2.0356690840892754e-08 / 3.987613565444208e-05 / 9.360516011381817e-06 / 8.9395947547362e-05 / 3.466378757720392e-06 / 1.2385647799184097e-05 / 3.6259855060459035e-05 / 0.00028446811679125046 / 4.3322170131610347e-07 / 3.6694829495818446e-05 / 1.3319185354685384e-05 / 0.0001450120364959482 / 0.0012382643384124116 / 0.00011198347385438923 / 1.2225430006781737e-05 / 2.2121210908325923e-06 / 0.004134037425943515 / 6.357933416947185e-05 / 0.0001845346362830905 / 1.1156277709036697e-05 / 0.0012012138503791107 / 0.0009113487575262121 / 0.00038512818063312726 / 0.00330460988510783 / 0.0011551309927923857 / 0.004248586177433409 / 8.696575941061198e-06 / 0.00035640811201797775 | 1.4826443090493311e-08 / 2.2740294469952764e-08 / 6.336269186082428e-09 / 3.539172375371934e-08 / 4.7609504610906553e-08 / 1.7960393747350935e-07 / 4.4916588042332195e-07 / 4.870463435270994e-07 / 2.0751734487343673e-08 / 8.867180726585433e-08 / 2.613509065423129e-07 / 4.2998193211784016e-08 / 2.9189015908569146e-07 / 7.796320698489975e-07 / 3.287953600510885e-07 / 4.184506818533476e-07 / 3.425164804138365e-07 / 2.6927928108537883e-07 / 1.5690808649462252e-07 / 6.082660419881746e-06 / 1.3924361879300207e-06 / 1.895443350505234e-06 / 2.370093060682893e-06 / 3.622834973607711e-06 / 3.7283263548613296e-06 / 6.922058937247929e-06 / 2.3405099437428686e-05 / 0.00010413370355979186 / 1.2402625610892681e-05 / 3.912517662348535e-06 / 9.101375208598654e-06 | 0.00058073 | 31 |
| 9 | LONRF1_4 | 0.0000000000 | 2.3042263304124516e-06 / 8.182623816859019e-08 / 7.449035561194172e-08 / 3.271165707863933e-07 / 3.872601102158526e-06 / 8.238465335223179e-05 / 1.020006295103392e-05 / 4.780055898330748e-05 / 6.0132262668712315e-05 / 0.00025833801594167625 / 4.823369084488708e-05 / 9.377014819070716e-08 / 1.8750944559946824e-05 / 0.0002257748867625031 / 4.61034011703085e-05 / 6.434547053133198e-06 / 0.0024160298697904117 / 6.16484303738615e-05 / 6.232941894500062e-06 / 8.832466534601092e-05 / 0.00014573543615757138 / 2.1793939320273974e-05 / 3.088478798821713e-05 / 5.3959564521511103e-05 / 8.545068477488772e-05 / 0.0010681118057163815 / 0.0006404527227598945 / 0.0010528904729959797 / 4.7004221317801894e-05 | 2.871690193004347e-09 / 7.780203727430123e-11 / 1.1090993827240565e-09 / 4.885836011088783e-09 / 4.3845626278981783e-08 / 3.800967952270995e-08 / 6.548683737212715e-07 / 9.934081050522841e-07 / 1.2258836498170386e-07 / 4.412782355372596e-07 / 9.84639797132252e-07 / 1.0962753584080669e-07 / 2.504876298772149e-06 / 4.981808633338559e-06 / 9.170385978844389e-07 / 3.2430481749669908e-06 / 5.197036451631831e-06 / 2.542113471225459e-06 / 2.116056737675851e-06 / 1.1892345151796726e-06 / 3.74526002970195e-05 / 3.3592564682108814e-06 / 6.814920333363255e-06 / 3.2430481749669908e-06 / 6.4967649552906986e-06 / 4.180561542903392e-05 / 3.3264582250052445e-05 / 8.095222217568488e-06 / 6.77844689688323e-05 | 0.000225153 | 29 |
| 10 | NUDT16_1 | 0.0000003288 | 2.7109747094287326e-07 / 5.2109649171464235e-06 / 9.224071980226081e-07 / 0.0004422271229621968 / 1.3062838211579366e-05 / 0.004583801528895219 / 0.0004771627200779347 / 3.2501044823812903e-07 / 5.2109649171464235e-06 / 0.0014854545690578267 / 6.979794879972793e-06 / 0.0019333915490623197 / 0.00043137964232097263 / 4.0242980256377906e-05 / 0.001077781567228248 / 3.54688199707126e-05 / 2.0071481202007584e-05 / 5.831891151164244e-05 / 0.0005120167928359619 / 4.559947241482223e-05 / 9.289397717877934e-06 / 0.0004073113752386311 / 0.017443989828652796 / 0.00025640470531776904 / 2.408755304649635e-05 / 3.1219185299958266e-05 / 5.1570472200670454e-05 / 1.615375160694009e-05 / 3.54688199707126e-05 | 5.385967484932456e-09 / 1.0900516853889578e-07 / 4.2678416681249765e-07 / 6.789788444310893e-08 / 5.701290417865207e-06 / 9.053292911304865e-07 / 8.186772624145206e-09 / 6.986597395696305e-07 / 9.299566826975888e-06 / 1.284325373822431e-07 / 3.519975525761359e-06 / 3.6551366345535073e-06 / 1.0585574831405579e-05 / 5.818012600528764e-06 / 8.591203793133295e-06 / 9.316488159288118e-07 / 1.764956512450499e-05 / 2.1357679726611226e-06 / 9.093604943452581e-06 / 1.5567150556965707e-05 / 3.245778635071659e-06 / 6.404889387734338e-06 / 4.079221141533871e-05 / 9.199981706216294e-06 / 4.3364053194329025e-06 / 2.601132064226823e-05 / 1.533327496967292e-05 / 2.2421339006083023e-05 / 2.984896137178954e-05 | 0.001015531 | 29 |
| 11 | BDKRB1_1 | 0.0000021162 | 2.051237402337122e-05 / 0.0002944288613709527 / 1.1263759452799203e-06 / 0.005398390884784092 / 0.00014547367344876742 / 0.0008581803853921776 / 9.971939174478468e-05 / 0.0001395680222164631 / 0.0005345324666238675 / 0.0026702661426604127 / 0.0036790499750236597 / 0.00036105139567184824 / 0.004298857351174951 / 0.0003301911422383287 / 0.006072266622156599 / 0.0028963504457353837 / 0.0008619933402586612 / 0.0014783442733670397 / 0.002082636216901017 / 0.0038265104822853674 / 0.0012393227037226365 / 0.0001249119186090808 / 0.0014783442733670397 / 0.009354429645569597 / 6.267778266652492e-05 / 0.0010353911778693099 / 0.0067509647795811235 / 0.00017366806695686554 | 7.120406194930282e-10 / 1.3196888168609393e-07 / 9.697204620602088e-09 / 1.088769714704053e-07 / 7.422682196769718e-08 / 6.17052942560377e-06 / 1.3710585742644193e-06 / 3.457696931263268e-08 / 2.6405169262238316e-06 / 1.036277076972443e-06 / 1.460759694934436e-06 / 3.8350091086392213e-07 / 1.266977339256832e-07 / 5.261863247063795e-07 / 1.698316254132078e-07 / 2.8478812173765797e-06 / 3.786868009340554e-07 / 1.8874782131634276e-06 / 5.371804546576567e-07 / 7.75343185764559e-06 / 9.483756578219822e-07 / 2.805248379242514e-07 / 2.019377115873876e-06 / 2.662855068818181e-07 / 2.339150064869274e-07 / 3.069489887698277e-07 / 2.1398422229289988e-05 / 3.835974713623205e-06 | 0.002009613 | 28 |
| 12 | ACVR1B_1 | 0.0000000083 | 9.289397717877934e-06 / 2.408755304649635e-05 / 0.0003167991900078877 / 9.224071980226081e-07 / 5.1570472200670454e-05 / 8.058554843717415e-06 / 0.00043137964232097263 / 0.0004771627200779347 / 0.0005120167928359619 / 0.004583801528895219 / 2.0071481202007584e-05 / 0.0014854545690578267 / 0.0019333915490623197 / 1.3062838211579366e-05 / 3.54688199707126e-05 / 0.00299921656722761 / 3.54688199707126e-05 / 0.00029640089162746337 / 0.0004073113752386311 / 4.0242980256377906e-05 / 4.559947241482223e-05 / 0.0004422271229621968 / 5.2109649171464235e-06 / 5.2109649171464235e-06 / 4.0242980256377906e-05 / 0.0005120167928359619 / 3.2501044823812903e-07 | 1.998372850901874e-09 / 1.0776011928357113e-07 / 5.6474630649123774e-08 / 4.2739967072439055e-08 / 5.763039230727411e-08 / 9.002284340324614e-08 / 7.938422465642845e-08 / 1.2831192229268504e-09 / 7.481479973456353e-07 / 1.5568154753866115e-07 / 1.3255462641590073e-07 / 1.2540923765124735e-08 / 1.1641859357749167e-06 / 6.487275081622067e-07 / 6.067873978076284e-07 / 4.061559955180453e-06 / 3.085926641657104e-07 / 2.1304437118144328e-07 / 1.614987656365666e-06 / 1.6505215509412846e-06 / 1.100046276296759e-07 / 7.257376518723062e-08 / 6.752087125171909e-06 / 5.013481886934968e-07 / 7.94905114529822e-06 / 2.0096587893651723e-06 / 1.4098818268841097e-06 | 0.00054563 | 27 |
| 13 | FUCA2_5 | 0.0000000000 | 7.326897656479634e-08 / 6.283050277058581e-07 / 6.33011695404466e-08 / 1.557810894407547e-08 / 1.4405701094138483e-07 / 8.973492705988831e-07 / 1.2247130912164364e-05 / 1.615099681752137e-08 / 1.0657346371809004e-06 / 2.6787796651465993e-05 / 1.9131942692024663e-06 / 1.7122549667747245e-06 / 1.8435980433182962e-05 / 1.6062625517222244e-05 / 2.1026075258297646e-05 / 4.784284498191245e-06 / 5.047975911248677e-07 / 3.7790277202725207e-05 / 0.00027096327284696815 / 4.4448750105807616e-06 / 9.795809542649757e-06 / 1.2637608316913067e-05 / 3.318559639876234e-05 / 0.00019702583169390873 / 0.0001046372470755123 / 1.6587047672491597e-05 | 2.695852819501535e-08 / 2.244217853888235e-07 / 2.1408641399345624e-09 / 4.459485961371418e-08 / 6.368941796707181e-08 / 1.6401205520911236e-06 / 9.97301936759034e-07 / 1.213349385759083e-08 / 8.60619982006544e-07 / 6.542182298700363e-07 / 2.4706785728123763e-06 / 2.8446904316163366e-07 / 3.1535389731478223e-06 / 4.116049846272149e-06 / 2.7284438670428954e-06 / 1.3028596303113042e-06 / 8.126089203342205e-06 / 1.927097516170564e-06 / 8.31845006069511e-06 / 2.632617725021655e-06 / 3.954576249334482e-06 / 2.2796504010207573e-06 / 2.8025242380326764e-05 / 3.9907455715014176e-05 / 1.0808234857902164e-05 / 1.4622833564552763e-06 | 3.05171E-05 | 26 |
| 14 | ZNF862_2 | 0.0000000000 | 5.757970402201313e-07 / 2.4029731505743387e-06 / 3.4338370713294263e-06 / 8.969803817399693e-06 / 3.673072285712733e-05 / 3.335194286983359e-06 / 9.35679667115326e-07 / 2.4638369795534228e-05 / 9.857812985592748e-06 / 4.7662233548054945e-06 / 4.252860467065013e-05 / 9.555888578983361e-05 / 2.9781866792031246e-05 / 0.0001422310318318236 / 2.0739253861638837e-06 / 2.0842424513236034e-05 / 0.0001466471398885516 / 1.960392177885001e-05 / 0.00014017916355145386 / 3.507870077084195e-05 / 2.8463522605801884e-06 / 9.490939642100406e-06 / 2.4179541415210912e-05 / 4.771691927687007e-05 / 0.0018357138624291076 / 0.0004214818735639107 | 6.669284403690585e-09 / 1.0986500719843909e-07 / 1.2920530726355395e-08 / 7.144193992690255e-07 / 8.897098518847435e-08 / 2.143448052078468e-07 / 1.1024290553572537e-07 / 1.4570264791055579e-06 / 5.394353982216976e-07 / 1.6497978521887276e-07 / 4.261784119390405e-06 / 3.913300846178839e-06 / 3.851296907021924e-07 / 1.3419887854662606e-06 / 7.36330097877341e-07 / 6.509968171609093e-06 / 6.683327596452262e-07 / 2.3915368068802614e-06 / 6.713901833795875e-06 / 1.1872388449378272e-06 / 1.4047060577114316e-06 / 1.484859827728269e-06 / 2.9956513765454837e-05 / 1.3836812552345798e-05 / 1.8400365047125074e-06 / 2.8632422146042694e-05 | 0.000119677 | 26 |
| 15 | JAKMIP2_1 | 0.0000003136 | 1.887107728600381e-05 / 0.00011602560329098725 / 0.0001432193232982916 / 0.0001432193232982916 / 0.0002441254991542676 / 0.006227948945630897 / 0.0003000003635118199 / 0.003136344446815041 / 0.0010434554869778357 / 0.001424661642376461 / 0.0004963923899259765 / 0.00011484315511043709 / 0.0011412468921657625 / 0.00033206653362091303 / 0.0011737393453168934 / 0.00021988598115354305 / 0.00019784908671616698 / 0.00033206653362091303 / 0.0007934067413946306 / 0.0007228851823325908 / 0.0003242200414121999 / 0.0033705319486407362 / 0.0020865035640383737 / 0.004284102869708787 / 0.001710012299865077 | 1.5055398107137094e-08 / 1.1317898810241505e-07 / 3.014192988473054e-07 / 6.562524735452552e-07 / 1.2620827414204395e-06 / 1.3813768678383736e-05 / 3.0528002185491916e-06 / 4.084105074757677e-06 / 1.2768262591823334e-06 / 8.84661511463528e-05 / 5.301506195235781e-06 / 3.73908096007415e-06 / 2.881552294460198e-07 / 3.7090918031637474e-06 / 8.877144806640423e-06 / 1.0731167574000379e-05 / 4.60217321009711e-06 / 3.1972497431176806e-06 / 7.72630923511333e-06 / 9.788516703431554e-06 / 1.694391766170071e-05 / 1.9122978701285485e-05 / 2.1160442665025628e-05 / 0.00012419843212817223 / 3.665339330112523e-05 | 0.001203905 | 25 |
| 16 | RHBDD2_2 | 0.0000000381 | 1.3853996990825065e-07 / 4.7520049447710837e-07 / 3.956087072154918e-06 / 1.280613569121123e-06 / 8.539102875978968e-07 / 2.5501614319254746e-05 / 0.0005420861101080113 / 5.7745918340825286e-08 / 8.776477751355082e-06 / 0.00015124776392064736 / 2.9520572987073497e-05 / 4.47869272440367e-06 / 1.140318186185745e-06 / 7.232001821345798e-06 / 3.9201554157572025e-06 / 4.4499857317195853e-07 / 6.930572497830363e-05 / 1.047470062062923e-07 / 0.00019163973853294472 / 7.3804316374052654e-06 / 3.6878940499153197e-07 / 2.2563184614877053e-05 / 0.0012079337533688077 | 1.3993846023737915e-07 / 4.7782451098120726e-08 / 1.34825995314718e-07 / 9.277238538824435e-08 / 7.956677787090288e-08 / 1.9225900129783712e-07 / 4.7263934234281247e-07 / 4.706709396786997e-07 / 6.949261184656789e-07 / 7.829247098324768e-06 / 5.071860028688062e-06 / 6.993311385406026e-06 / 1.4497257721405869e-06 / 1.0714836567004093e-06 / 1.4372683450836863e-06 / 4.455852411812759e-07 / 1.815987875798767e-05 / 5.0475687702261924e-05 / 2.8193572587039603e-05 / 1.0465678177194616e-06 / 9.053292911304865e-07 / 7.583935924635759e-06 / 9.83485693819911e-06 | 9.91481E-05 | 23 |
| 17 | NELL2_2 | 0.0000000034 | 1.6974372024295342e-05 / 6.21390552863653e-07 / 7.492219023207615e-07 / 0.00033397296479027066 / 6.419532166056714e-06 / 3.680752556412065e-06 / 2.702881264505673e-05 / 0.0001892136695208884 / 0.00013627250802194024 / 4.7592039918640816e-05 / 0.0006954055695635021 / 1.6060512405884523e-05 / 0.00020956984034738803 / 6.893999398193879e-07 / 2.7044709406151057e-06 / 1.030767276264569e-05 / 0.00011664561575068539 / 7.396819433180742e-05 / 0.0033003547134611197 / 0.0007339964856567068 / 3.212738000062656e-05 / 5.509863153367014e-05 / 0.0014134565502491926 | 1.805210992172401e-08 / 1.036277076972443e-06 / 1.6727928235519174e-05 / 1.3595686728091487e-05 / 3.109078579168171e-07 / 2.9751938937015323e-06 / 3.0194508969201275e-06 / 1.6481167858879217e-07 / 1.0183622735900536e-06 / 2.551343424529328e-06 / 8.778520319265194e-07 / 4.509011181702684e-05 / 3.1588674679295282e-06 / 4.870956378452621e-06 / 4.222740574602922e-06 / 9.393121861778026e-06 / 5.533180942415662e-06 / 2.6252332329450155e-05 / 8.461228664041275e-06 / 2.9713091532112142e-05 / 5.2787519047573424e-05 / 2.9042216064749748e-05 / 4.1781335008242154e-05 | 0.000322735 | 23 |
| 18 | LIPI_3_23 | 0.0000000000 | 8.447946079053626e-08 / 1.205208755759072e-06 / 4.854502381230392e-07 / 2.1301603555625764e-05 / 6.853246565784258e-06 / 2.1960012732279454e-05 / 2.6827365804354637e-05 / 1.2548296867935075e-05 / 0.0002009891841455023 / 4.514325991172083e-05 / 6.291115981061851e-05 / 3.312532784218011e-05 / 6.011489855493573e-07 / 0.00014831370330060418 / 1.7445373847640036e-05 / 0.004714448601828642 / 0.0032002760896811776 / 0.0004620869369249564 / 0.0003755600058949459 / 1.2884839156193493e-05 / 0.0011512736162346696 / 0.00013581452355279118 / 0.0009812281151223513 | 5.468987072460599e-10 / 2.6158726903289238e-08 / 3.565426338432271e-08 / 8.478661382630348e-07 / 3.875609327625631e-07 / 4.840300983601908e-07 / 8.703948887755087e-07 / 9.72132002734069e-07 / 6.098991982334273e-07 / 3.658889330776619e-06 / 1.739637519533283e-05 / 3.2315430831611734e-06 / 8.154288030550316e-08 / 3.3855189139433126e-06 / 1.76044274336364e-06 / 3.077281478322042e-06 / 7.717215517819916e-05 / 3.986852616595454e-05 / 0.0001488041159355547 / 4.81219243302854e-06 / 3.139552211698547e-05 / 2.5976982501110966e-05 / 1.2619626971823594e-05 | 0.000505799 | 23 |
| 19 | RUNX1_1 | 0.0000001763 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 5.1570472200670454e-05 / 0.005510243055764825 / 0.0019333915490623197 / 2.408755304649635e-05 / 0.0005120167928359619 / 2.7109747094287326e-07 / 1.3062838211579366e-05 / 3.54688199707126e-05 / 0.0006200425273220967 / 0.00029640089162746337 / 5.2109649171464235e-06 / 8.058554843717415e-06 / 5.2109649171464235e-06 / 0.0006813940301036226 / 0.0003167991900078877 / 5.831891151164244e-05 / 0.0017723102864169204 / 6.979794879972793e-06 / 4.491442887170463e-06 | 1.1641966632063906e-10 / 7.92535031547177e-09 / 5.753632350484074e-09 / 1.0677978948737271e-07 / 3.665113066608255e-07 / 1.4992785773118291e-06 / 1.2569627975426034e-06 / 4.294667785263063e-07 / 2.58629690488761e-06 / 6.186351504175007e-07 / 2.7175791335738627e-06 / 5.643067361003201e-07 / 1.7425168489071174e-06 / 1.244203208123666e-06 / 1.3319999198783528e-06 / 7.864816120590302e-08 / 1.998199593822845e-07 / 3.4658375428977435e-06 / 1.228062366600316e-06 / 1.3596443786771905e-05 / 1.714256584966273e-06 / 4.1558712164911445e-06 / 1.5033075637026901e-06 | 0.00051678 | 23 |
| 20 | UGT3A2_1 | 0.0000012269 | 9.224071980226081e-07 / 3.2501044823812903e-07 / 2.408755304649635e-05 / 6.979794879972793e-06 / 0.0003167991900078877 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 2.0071481202007584e-05 / 8.058554843717415e-06 / 0.0004073113752386311 / 4.0242980256377906e-05 / 5.2109649171464235e-06 / 0.0005120167928359619 / 3.54688199707126e-05 / 0.0019333915490623197 / 9.224071980226081e-07 / 0.017443989828652796 / 1.615375160694009e-05 / 5.2109649171464235e-06 / 5.1601659937199475e-05 / 0.00029640089162746337 / 0.0019333915490623197 / 5.1570472200670454e-05 | 1.381799790744931e-09 / 1.805210992172401e-08 / 9.694448730531385e-08 / 4.403550218821958e-07 / 2.9355105945215545e-08 / 1.045969028083387e-07 / 3.835974713623205e-06 / 2.3222021704967167e-07 / 4.773025688625418e-08 / 9.343660219128231e-07 / 3.6689667424468134e-07 / 2.4140542299703294e-06 / 3.1276785123692046e-07 / 5.018595857384795e-07 / 2.387431583758606e-06 / 1.0035560526801471e-07 / 2.2657213911761568e-05 / 1.0022702721591722e-05 / 9.972925901562962e-06 / 1.8557759701880527e-06 / 1.554298505895915e-06 / 2.5796549872310057e-06 / 4.9185008634943495e-06 | 0.001005204 | 23 |
| 21 | SLAIN1_2 | 0.0000000001 | 1.3401582342156554e-08 / 7.359704703027111e-07 / 4.659755401849588e-08 / 0.00012785013168945162 / 3.4192931304829014e-06 / 4.592877446409494e-06 / 5.207246052888057e-07 / 3.633081984870721e-07 / 4.05395891219117e-07 / 4.835640776889601e-06 / 4.602166722353917e-05 / 2.225580423517811e-06 / 5.326859676055172e-06 / 2.0535846739106096e-05 / 1.3942380334535833e-06 / 1.096889887353167e-06 / 4.77141612260032e-05 / 4.592877446409494e-06 / 0.00011487199668000062 / 0.00021267966425080588 | 7.85839937243628e-09 / 4.2881222404900966e-09 / 4.232043687265545e-08 / 4.48703162941859e-07 / 3.401659596258682e-07 / 5.695617165978249e-07 / 3.159236368559607e-07 / 1.9077743153626155e-07 / 1.305430203445936e-06 / 3.594837020072477e-05 / 1.4937326562948882e-07 / 9.345028580131548e-07 / 2.9676196803014993e-06 / 2.4190454710072306e-06 / 7.316779637097216e-06 / 2.031054374651815e-06 / 4.1261024294080975e-06 / 4.360382079203378e-06 / 1.3128908636239939e-06 / 3.4828848664424397e-06 | 2.99622E-05 | 20 |
| 22 | TRPM4_3 | 0.0000000003 | 9.196770242715937e-09 / 2.664719965991362e-08 / 3.725931030072998e-06 / 2.0944901905984007e-05 / 1.347120953229711e-06 / 1.0865942049799405e-07 / 0.00047815490214213265 / 9.236060166459222e-07 / 3.900469077615773e-06 / 8.121356876763278e-06 / 7.49526869739906e-07 / 0.0042689591705948856 / 8.209562763309459e-06 / 1.5485664592082808e-05 / 2.1196123383966528e-05 / 3.5495647595004414e-05 / 3.8020455601505727e-07 / 1.8325658404407734e-05 / 1.9521118173804467e-05 / 3.311124664582957e-06 | 2.1749725015902454e-10 / 2.0414050703934923e-08 / 3.1693546387669756e-07 / 3.0408081748624807e-06 / 9.653812249086853e-07 / 2.9355105945215545e-08 / 2.00027266182616e-05 / 2.7663883060711165e-06 / 5.405035911800092e-07 / 1.8142742683524817e-06 / 4.794639512641633e-06 / 7.1412649173752545e-06 / 1.0690993559290582e-05 / 4.620846133046724e-06 / 2.5629460029005674e-06 / 1.8751868580077024e-05 / 9.824959916701546e-06 / 6.0957425825213314e-06 / 2.2006142512020074e-05 / 3.4448329577362182e-06 | 0.000245445 | 20 |
| 23 | SLC24A3_1 | 0.0000000210 | 1.1263759452799203e-06 / 2.051237402337122e-05 / 9.971939174478468e-05 / 4.369070707050029e-05 / 0.00017366806695686554 / 0.0008581803853921776 / 0.00014547367344876742 / 0.0001395680222164631 / 0.0001249119186090808 / 0.0002944288613709527 / 0.0010353911778693099 / 6.267778266652492e-05 / 0.0006503983018257066 / 0.0012393227037226365 / 7.924407878618111e-05 / 0.0002944288613709527 / 0.0008619933402586612 / 0.0026702661426604127 / 1.7999540459370774e-05 / 0.0031060111248571412 | 6.407832325684251e-09 / 9.240926568058304e-09 / 9.966453961357818e-08 / 3.08922513577382e-07 / 8.520500454117749e-07 / 7.642146337997833e-07 / 2.5299574218373655e-07 / 7.330469554133431e-08 / 1.6814800128714516e-07 / 6.0957425825213314e-06 / 2.9345983642597263e-07 / 1.0181132930253954e-06 / 3.4215164228215663e-07 / 4.6580022097987207e-07 / 8.830988008417038e-07 / 2.65171239271242e-06 / 2.322060799489299e-06 / 9.727443509821518e-06 / 3.786868009340554e-07 / 1.0862691344015027e-05 | 0.000595951 | 20 |
| 24 | NCKAP1L_1 | 0.0000001762 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 4.0242980256377906e-05 / 5.2109649171464235e-06 / 0.0004073113752386311 / 0.00029640089162746337 / 0.0003167991900078877 / 5.2109649171464235e-06 / 3.54688199707126e-05 / 0.017443989828652796 / 9.289397717877934e-06 / 5.1601659937199475e-05 / 2.7109747094287326e-07 / 0.0005120167928359619 / 8.058554843717415e-06 / 2.408755304649635e-05 / 0.0019333915490623197 / 1.3062838211579366e-05 | 7.9904530083348e-11 / 2.4994053567542328e-09 / 9.924736193254942e-08 / 1.8132622674092954e-07 / 1.4200503117731924e-07 / 2.069668183072629e-07 / 1.2682052722257146e-06 / 2.9447437356082395e-07 / 6.313636923660506e-07 / 3.0174324318950897e-07 / 4.4682920249147006e-07 / 1.7578808963170404e-05 / 4.263423766146041e-07 / 7.92201170417271e-07 / 9.008258721422489e-07 / 2.0908224860853314e-06 / 3.056396462394648e-07 / 1.3307689369536397e-06 / 5.981606289641214e-06 / 2.3027940859808657e-06 | 0.001056536 | 20 |
| 25 | RAB32_3 | 0.0000000000 | 7.292182530573412e-05 / 0.0003225223870914812 / 2.2327691127733746e-05 / 0.00038393847007829764 / 3.886421476307484e-05 / 0.00013655060364162736 / 0.00024209823898958905 / 1.5637203423692577e-05 / 2.238208719127431e-05 / 0.0002565324608559162 / 1.0853983312684394e-05 / 3.3987574572169257e-06 / 0.003487304520950219 / 0.0014199624577438193 / 0.00016938096923286043 / 0.0003781658379275213 / 0.0039368730296373096 / 0.0023817198498238316 / 0.0021712362602544022 | 1.0130573619295235e-08 / 5.741020731646927e-08 / 9.202018333928226e-08 / 1.4025070456802076e-07 / 7.718777494211644e-07 / 7.407426548536711e-08 / 1.8556041703527292e-07 / 5.751375891322542e-07 / 9.654719902897998e-07 / 2.0179929179508126e-07 / 2.4077694825580987e-06 / 7.539024856072121e-08 / 1.4948990890785054e-06 / 3.549228834149341e-06 / 2.6963041058083467e-06 / 5.538818081011408e-06 / 9.408104215481871e-06 / 7.311276565893818e-07 / 5.17516813573647e-06 | 0.000814351 | 19 |
| 26 | E2F5_1 | 0.0000004973 | 4.335544688590604e-05 / 0.0016610593752756947 / 0.00015165886425239433 / 0.0020037138718268558 / 0.0062926107897605076 / 0.008954836987534829 / 0.0013997024178051241 / 0.0017438515808585928 / 0.005852051539088946 / 0.0013991989944309945 / 0.0037308274054686026 / 0.001807326102912818 / 0.0014458717426393303 / 0.0006825622924508404 / 0.006160732768120326 / 0.008954836987534829 / 0.004687460046810221 / 0.0001360945704417454 / 0.0072609125485500695 | 2.612437800154611e-10 / 1.5925972264030232e-08 / 3.100531350503503e-08 / 6.448536988230897e-08 / 5.466544241455998e-07 / 3.2169896739895314e-07 / 3.1906789245845806e-06 / 2.3096174786096604e-06 / 1.0141504136839242e-06 / 2.260690937267708e-06 / 9.279972919171246e-07 / 2.847754855927293e-07 / 6.680245031011018e-06 / 5.490090984753377e-06 / 1.077519353313373e-06 / 5.376695975590836e-06 / 4.7530598444137695e-06 / 2.3590259977159812e-06 / 8.340398610953811e-06 | 0.003387824 | 19 |
| 27 | RBM11_5 | 0.0000000000 | 1.4526084780295787e-06 / 5.443773486089936e-07 / 1.1971991474232777e-05 / 6.91934628205793e-05 / 2.5796294158785155e-05 / 2.552372456547772e-05 / 1.829615188324561e-05 / 0.00032472688716174674 / 0.001180151638718015 / 4.2244922676709556e-05 / 0.00017279410375636235 / 0.0051673606935049915 / 2.6544638405574182e-05 / 1.4103499755990336e-05 / 0.0008670088401703034 / 0.00038070130611975926 / 0.0007339140203518938 / 0.0002219001663689648 | 3.3998096773618356e-07 / 1.045969028083387e-07 / 8.800196900298445e-06 / 8.936798924355491e-07 / 2.208556405239799e-06 / 2.223017106257352e-06 / 4.845393516836826e-06 / 2.2421339006083023e-05 / 4.345707282768042e-05 / 1.8399624316894983e-05 / 8.025474759619109e-07 / 0.00010333461220899216 / 3.039816166758595e-05 / 1.0072708544500107e-05 / 1.0221468717522446e-05 / 0.0001719448294932468 / 8.296198213269645e-05 / 2.393187109770829e-05 | 0.000515791 | 18 |
| 28 | JHDM1D_1 | 0.0000000465 | 1.887107728600381e-05 / 0.0019194247450850443 / 0.0010434554869778357 / 0.00021988598115354305 / 0.00011602560329098725 / 0.0005437871552770366 / 0.0001432193232982916 / 0.00019784908671616698 / 0.00033206653362091303 / 0.0003000003635118199 / 8.177669445709026e-05 / 0.0019387958818788326 / 0.0020865035640383737 / 0.00019784908671616698 / 0.0003935478447180597 / 0.002087197919276702 / 0.00033206653362091303 | 5.957947041241642e-10 / 4.7213815560041737e-07 / 1.2953287867816182e-06 / 1.517275876808106e-07 / 2.0848690809316758e-07 / 2.1505701666588e-07 / 7.184717182652482e-08 / 3.4470235709692284e-07 / 6.582103467311211e-07 / 3.4690122473485e-07 / 2.581774969081794e-07 / 2.783019047305537e-07 / 2.2587138448042827e-06 / 3.436077993294023e-07 / 1.3808771629119943e-07 / 1.0777981400774649e-06 / 4.837594802084705e-06 | 0.000703078 | 17 |
| 29 | SDC1_2 | 0.0000000025 | 3.24920563754477e-05 / 1.3377106429420062e-05 / 2.286373051099475e-05 / 8.919615355047188e-05 / 0.00015487870247863725 / 0.0003070420132331339 / 6.552854468616073e-05 / 0.010204546359181573 / 0.0004579043420381389 / 0.0003133243150903811 / 1.2750924916385893e-05 / 2.9619864783219557e-05 / 0.00011623700055853398 / 1.6676618048371524e-06 / 0.0002836145894393715 / 0.0014642811488913923 / 3.349324237754571e-06 | 1.446249458351141e-08 / 1.1593366582600526e-07 / 1.8212505086597223e-07 / 2.805221831770931e-07 / 1.52555181061785e-07 / 1.3421491093673395e-07 / 5.838895464045765e-08 / 8.431612764947411e-07 / 1.4442373350859127e-06 / 2.7186262684030095e-06 / 5.355505538740775e-07 / 1.058510323843106e-06 / 6.635824670736839e-07 / 3.247865406241601e-05 / 4.51316772311888e-06 / 2.621113516811208e-07 / 1.9091723806799227e-06 | 0.000798393 | 17 |
| 30 | ENPP3_2 | 0.0000000002 | 7.220251902586713e-08 / 1.5415033312027603e-05 / 2.140496501618477e-08 / 1.0829140297466289e-09 / 4.864296167501907e-07 / 4.1398213999064624e-06 / 1.3483681400210042e-06 / 6.882770012055959e-06 / 5.9617084438303865e-06 / 3.539399887995572e-05 / 1.2072926853768964e-05 / 1.1605014260398891e-06 / 3.934765724180659e-07 / 1.3398427589553948e-05 / 2.132615896596937e-05 / 2.4103457859893014e-05 | 1.9517835933891448e-08 / 2.248231048691535e-08 / 4.830482337300574e-08 / 1.481967113051988e-07 / 4.175954165049041e-08 / 1.6171122367004618e-07 / 1.6052769492778243e-06 / 4.900800780379338e-07 / 9.924621104960267e-07 / 2.3418243309125566e-06 / 5.843072350429807e-07 / 3.2579388947351196e-06 / 1.1836495389262217e-06 / 1.1411599622062492e-05 / 2.843023304997815e-06 / 1.828727174279431e-05 | 8.88611E-06 | 16 |
| 31 | RBM33_1 | 0.0000000000 | 9.289397717877934e-06 / 3.2501044823812903e-07 / 6.979794879972793e-06 / 5.1570472200670454e-05 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 4.491442887170463e-06 / 2.408755304649635e-05 / 5.2109649171464235e-06 / 3.54688199707126e-05 / 3.54688199707126e-05 / 0.0004073113752386311 / 5.1601659937199475e-05 / 0.00043137964232097263 / 4.0242980256377906e-05 / 5.2109649171464235e-06 | 8.944918223939934e-09 / 9.053698775288811e-09 / 2.5457122572689533e-07 / 1.5628889781375459e-07 / 9.626516148430137e-08 / 4.9661337040464625e-08 / 1.4653913639914694e-07 / 9.345028580131548e-07 / 1.2202889190119188e-07 / 1.2069281833924902e-06 / 3.4985449908631084e-07 / 3.210007225110076e-06 / 3.041361665158829e-06 / 7.856862302531046e-06 / 1.7638568513415927e-06 / 8.270219208624064e-07 | 6.93645E-05 | 16 |
| 32 | MYOM2_1 | 0.0000000034 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 1.3062838211579366e-05 / 9.289397717877934e-06 / 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 0.001077781567228248 / 5.2109649171464235e-06 / 3.54688199707126e-05 / 0.0006200425273220967 / 5.1570472200670454e-05 / 3.1219185299958266e-05 / 0.0005820808941317769 / 2.7109747094287326e-07 | 7.84964801360265e-09 / 1.1586817234891624e-08 / 6.152115559989733e-07 / 1.6684003331859656e-07 / 3.958329447265834e-09 / 4.242888917541819e-08 / 2.859898115713063e-07 / 2.0425825542054087e-07 / 4.255278048064328e-06 / 4.538593419582914e-07 / 1.2927770179758555e-06 / 4.840614386607516e-07 / 6.826429036349635e-07 / 3.953740273881905e-07 / 1.6027712459664707e-07 / 1.277864202481348e-06 | 0.000153777 | 16 |
| 33 | ADRB1_1 | 0.0000010659 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 9.289397717877934e-06 / 5.2109649171464235e-06 / 5.2109649171464235e-06 / 3.1219185299958266e-05 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 5.1570472200670454e-05 / 3.54688199707126e-05 / 0.00299921656722761 / 1.3062838211579366e-05 / 2.408755304649635e-05 / 1.615375160694009e-05 / 0.0006200425273220967 | 2.5354833517437137e-10 / 1.2841215292330722e-08 / 3.315225754524024e-08 / 8.863210863839688e-09 / 2.599695216645358e-08 / 5.874422234352583e-08 / 2.2101941341811467e-07 / 9.580348649532748e-07 / 2.32003591797698e-06 / 1.3844257761317394e-06 / 2.4253616535611087e-06 / 9.891342242857947e-06 / 1.1746244916516119e-05 / 2.092495310550426e-06 / 3.681660463815629e-06 / 1.4268112459432864e-05 | 0.000239944 | 16 |
| 34 | FAM19A5_1 | 0.0000000251 | 2.051237402337122e-05 / 0.0001249119186090808 / 1.1263759452799203e-06 / 0.00014547367344876742 / 0.004362771524153584 / 6.267778266652492e-05 / 0.00036105139567184824 / 0.004298857351174951 / 0.0026702661426604127 / 0.0002944288613709527 / 0.0008619933402586612 / 0.0001395680222164631 / 0.0012393227037226365 / 0.0006503983018257066 / 0.0010353911778693099 / 0.006283046490797941 | 3.7316428195760516e-08 / 4.801672877175668e-08 / 2.2512706653969313e-08 / 2.2270178280725655e-08 / 1.1663586146149853e-07 / 5.1617837573062526e-08 / 9.920288294972892e-08 / 1.0628762332633252e-07 / 7.803934546881044e-07 / 1.2557942267792308e-06 / 3.618961161943627e-07 / 1.737206632640488e-06 / 1.114198886925796e-06 / 1.737206632640488e-06 / 4.390716794223026e-06 / 1.5851926645157727e-06 | 0.001409487 | 16 |
| 35 | CDK6_2 | 0.0000001305 | 0.00013786395373714154 / 0.00012482662815781762 / 6.30950668542991e-06 / 3.539797690840022e-05 / 0.0021106959648809795 / 0.0019402604943496325 / 0.0004050172910570013 / 0.003362553960006399 / 0.0013208680612235583 / 0.00017037141729627674 / 0.007026007804580723 / 0.0006307912742552862 / 0.006254122709575149 / 0.000452462941181013 / 0.009290134594271832 / 0.0022577052814897595 | 1.9544766970910803e-08 / 3.902848227411897e-06 / 1.1734588197031495e-06 / 1.1118487852102413e-06 / 1.8215667472555084e-06 / 1.2168005067226621e-05 / 1.2378495979370532e-05 / 1.2610279737677179e-06 / 7.585840312719431e-06 / 1.7309657386672318e-06 / 1.4962029489277431e-05 / 1.155615785434093e-05 / 9.614370500489897e-06 / 5.003114862001264e-06 / 5.28580544479192e-05 / 1.4068709149077956e-05 | 0.002220337 | 16 |
| 36 | C1orf54_1 | 0.0000004284 | 0.0014458717426393303 / 0.0020037138718268558 / 4.335544688590604e-05 / 0.0016610593752756947 / 6.184726372815994e-05 / 0.0001877376372184388 / 0.004687460046810221 / 2.6541144234526445e-05 / 0.0072609125485500695 / 0.00020855415394078816 / 2.305129761580306e-05 / 0.0017438515808585928 / 0.0003838064547253506 / 0.02641074680572614 / 0.0006215281984981403 / 0.004345907558402852 | 4.431617867534599e-08 / 9.764176338067594e-08 / 1.6551951268345963e-08 / 5.4670195572463556e-08 / 8.693119479065898e-08 / 6.467247715906918e-08 / 1.3820781181904612e-07 / 2.601353524092188e-07 / 1.4346332512235168e-06 / 9.391637246842195e-07 / 2.1381221213988253e-05 / 2.0697206630187898e-07 / 2.0216248384142136e-05 / 1.3296295127951121e-05 / 4.089595896778703e-05 / 6.182750614867968e-06 | 0.003194747 | 16 |
| 37 | HOOK1_1 | 0.0000000509 | 3.2501044823812903e-07 / 2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 9.289397717877934e-06 / 0.017443989828652796 / 0.0019333915490623197 / 5.2109649171464235e-06 / 0.0003167991900078877 / 8.058554843717415e-06 / 3.54688199707126e-05 / 1.3062838211579366e-05 / 0.0004073113752386311 / 0.001077781567228248 / 2.408755304649635e-05 / 0.03666459832926511 | 6.576012762267339e-08 / 1.4455622042691941e-06 / 4.885610187770645e-07 / 3.76701623356669e-07 / 1.8059093721170035e-06 / 2.676171176620618e-05 / 5.749753783810232e-05 / 1.1638593888237151e-05 / 8.633538811448395e-06 / 1.5664395352028368e-06 / 2.090650282526137e-06 / 2.5661246047916315e-05 / 1.5202656143498954e-05 / 9.9612781999649e-06 / 1.6231643656615e-05 / 0.00012445882667471073 | 0.003621722 | 16 |
| 38 | EVI2A_1 | 0.0000000779 | 2.0071481202007584e-05 / 1.3062838211579366e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 0.0006200425273220967 / 3.54688199707126e-05 / 0.006968336904458093 / 5.2109649171464235e-06 / 0.0019333915490623197 / 5.2109649171464235e-06 / 0.00029640089162746337 / 0.002238680629992204 / 0.0006813940301036226 / 2.408755304649635e-05 | 1.5609086500143182e-09 / 2.4274791706684804e-07 / 1.3635987406508816e-07 / 1.6189487637413584e-07 / 3.704245549261797e-08 / 5.850917111819974e-07 / 4.021754229335225e-06 / 5.99711639772174e-06 / 5.939256052201768e-07 / 5.306927531917352e-06 / 1.752058259452043e-06 / 3.3967361752805547e-06 / 1.4521128153120201e-05 / 2.839421384468485e-05 / 1.9278657989741134e-05 | 0.000856793 | 15 |
| 39 | KDSR_1 | 0.0000003143 | 1.887107728600381e-05 / 0.0005437871552770366 / 0.002087197919276702 / 0.0001432193232982916 / 0.00021988598115354305 / 0.002087197919276702 / 0.0010434554869778357 / 0.0002441254991542676 / 8.177669445709026e-05 / 0.006227948945630897 / 0.0016193402238388898 / 0.00033206653362091303 / 0.0001432193232982916 / 3.139293208316785e-05 / 0.001424661642376461 | 7.774619885339959e-09 / 9.17707137009986e-09 / 6.345932895218097e-07 / 3.824093835557216e-08 / 4.870463435270994e-07 / 1.781378071484659e-07 / 1.5486153095797136e-06 / 3.2667817640867473e-06 / 9.66394881627529e-07 / 1.054382095817476e-05 / 7.511357995471599e-06 / 2.1985427007215493e-06 / 4.469268122727537e-06 / 5.302698252478667e-06 / 5.826180628047725e-05 | 0.00108321 | 15 |
| 40 | TRIM69_1 | 0.0000000466 | 1.887107728600381e-05 / 0.0002441254991542676 / 0.0001432193232982916 / 0.0004863107130580812 / 0.0001432193232982916 / 0.00021988598115354305 / 0.00021988598115354305 / 0.0005437871552770366 / 8.177669445709026e-05 / 0.0016193402238388898 / 0.006227948945630897 / 0.0003935478447180597 / 0.002087197919276702 / 0.0001432193232982916 / 0.016123082594735844 | 1.1433357759584753e-08 / 8.836349820396399e-08 / 1.0186144265985267e-07 / 9.978329579501906e-08 / 5.327953099928334e-07 / 2.0403148485445152e-07 / 1.36202730898669e-07 / 1.8476610323825603e-07 / 1.9599293797405736e-06 / 1.3645862654437664e-06 / 4.736723443537097e-06 / 3.824375400480388e-06 / 1.7111709589036534e-06 / 5.410761494405694e-07 / 1.1672532290928993e-05 | 0.001913028 | 15 |
| 41 | FAM69A_1 | 0.0000000702 | 0.0013130417279779386 / 0.00015668136762185704 / 0.000580627296776329 / 0.00021513618339111576 / 0.0006379488254521119 / 0.0038002956245117296 / 0.00023863087793556863 / 0.009089976463332457 / 0.009732706737130784 / 0.0015596001225492795 / 0.0012028677089548085 / 0.0020078773138146426 / 0.0007003039227988429 / 0.010574324269088433 / 0.00442535226656398 | 5.207979195444387e-10 / 2.3954906890799492e-08 / 8.376642315944637e-08 / 3.029086308872845e-09 / 8.2602839443737e-08 / 4.5432680388905903e-07 / 3.4215164228215663e-07 / 3.6227709430270065e-07 / 1.1119851588379871e-06 / 9.884962787115456e-07 / 6.58864064133256e-07 / 1.9066424564105585e-07 / 1.0175118608827892e-07 / 9.736821003526402e-06 / 2.2836387735375516e-06 | 0.003082358 | 15 |
| 42 | MCF2_1 | 0.0000000950 | 0.002107325343692074 / 0.0007073001228128905 / 0.0016226906289916678 / 0.013331886853589549 / 0.004410274724633273 / 0.004410274724633273 / 3.1219185299958266e-05 / 0.0011323441860117745 / 0.005133998810813905 / 8.807499017205126e-05 / 0.008672939675174867 / 3.54688199707126e-05 / 0.0016232581034909483 / 8.11064679353273e-05 / 0.019751746709410014 | 2.8385942053147423e-07 / 7.000874559889031e-07 / 1.0191814816838582e-06 / 1.937510906526569e-06 / 1.219795851846249e-06 / 1.1273301221243648e-06 / 7.451700758866295e-08 / 4.510350188873355e-07 / 1.6503324272286632e-06 / 9.824741991349808e-05 / 7.86885268932808e-06 / 2.4523766799232255e-06 / 8.771491504288576e-06 / 4.472728712108301e-06 / 6.181222965809451e-06 | 0.004209327 | 15 |
| 43 | DNMT3A_1 | 0.0000000038 | 3.2501044823812903e-07 / 2.7109747094287326e-07 / 9.224071980226081e-07 / 1.615375160694009e-05 / 9.289397717877934e-06 / 0.017443989828652796 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 5.1570472200670454e-05 / 0.0006813940301036226 / 5.2109649171464235e-06 / 2.408755304649635e-05 / 0.0003167991900078877 / 0.04025623380130843 / 0.016412811603890378 | 8.647692450087712e-10 / 3.609830399524262e-08 / 1.0850349172583042e-07 / 4.2367786991922625e-07 / 5.547034323026097e-08 / 4.995600154079587e-06 / 9.034850264291034e-07 / 1.1942660873924224e-07 / 3.4764046668097013e-06 / 1.1899456022044518e-05 / 4.064896475030508e-06 / 5.950697198132815e-06 / 2.1639192493163854e-06 / 0.0003267886041800874 / 2.5073506475872135e-05 | 0.005016004 | 15 |
| 44 | RAP1GAP_1 | 0.0000001086 | 1.3062838211579366e-05 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 3.54688199707126e-05 / 5.2109649171464235e-06 / 2.7109747094287326e-07 / 9.289397717877934e-06 / 8.058554843717415e-06 / 5.2109649171464235e-06 / 2.408755304649635e-05 / 6.979794879972793e-06 / 5.1570472200670454e-05 / 9.224071980226081e-07 / 0.0004073113752386311 | 1.0234263973416661e-07 / 8.919463455114289e-08 / 3.3072632243081114e-08 / 1.5105555334027616e-07 / 2.5836122972488502e-08 / 1.2756238211643116e-07 / 9.299416219218907e-08 / 2.1342000804921115e-07 / 7.37724046840261e-07 / 6.300687009130246e-07 / 3.3529930477004465e-06 / 2.385355833544641e-06 / 9.364193044327943e-08 / 5.244484117278139e-06 | 4.06208E-05 | 14 |
| 45 | GCNT1_2 | 0.0000000002 | 2.78484877909426e-05 / 4.864296167501907e-07 / 9.764023441666015e-05 / 2.140496501618477e-08 / 0.00016651089487352638 / 3.0074215404236193e-05 / 0.0006617980305097352 / 1.3483681400210042e-06 / 4.031241782169131e-05 / 1.1981309904526152e-06 / 5.587185227944235e-07 / 1.0829140297466289e-09 / 7.220251902586713e-08 / 3.539399887995572e-05 | 1.8148339446273985e-07 / 6.847165231186148e-07 / 2.165545875875814e-05 / 2.3188274882197003e-07 / 6.0280690987430294e-06 / 5.2750455191025595e-06 / 4.06671138458547e-05 / 1.2997762974345022e-06 / 2.2170187832829583e-06 / 6.9576009368884445e-06 / 9.170085944984048e-06 / 1.1905756638522483e-06 / 5.8239343353291375e-06 / 2.5038906043292028e-05 | 7.59475E-05 | 14 |
| 46 | ACVR2B_1 | 0.0000024645 | 0.004342013504637762 / 0.010062997503423064 / 0.01546878234616017 / 0.0043172887751955534 / 0.004147048109487421 / 0.0027366161949255864 / 0.004302356273800125 / 0.003851105873342487 / 0.010924554738209911 / 0.0034419337702655166 / 0.0016993523409038112 / 0.008815441252326467 / 0.010035816045194686 / 0.0003588157506217931 | 4.6969645977238944e-08 / 1.0646048244254027e-06 / 2.074984122638114e-06 / 1.6464210539762824e-06 / 3.55074742901801e-07 / 8.336014361253352e-07 / 1.0819897944403119e-06 / 6.649001393280087e-07 / 1.771560615564129e-07 / 2.1882250573351623e-06 / 5.884742871708681e-07 / 1.359935106570381e-05 / 2.757047405189331e-06 / 3.7316428195760516e-08 | 0.006036009 | 14 |
| 47 | FLII_1 | 0.0000003706 | 0.013438701196916187 / 0.0013131196768949175 / 0.001313597832987636 / 0.010966427251690712 / 0.0010967995115722952 / 0.00283637665495315 / 0.020637719307260594 / 0.009544509177234737 / 0.011113919331766907 / 0.002612407689400646 / 0.00014659710165947198 / 0.011743117027967754 / 0.003613135281467632 / 0.021113557190889712 | 2.0358630016163756e-07 / 9.38178289658818e-07 / 1.5768550290633048e-06 / 4.170842922005371e-07 / 1.2667845868111258e-06 / 5.267900245960507e-07 / 1.0328138955557601e-05 / 2.5703309767846595e-06 / 9.713959639172909e-06 / 4.879856421117728e-06 / 5.689594876108628e-07 / 5.210656857814663e-06 / 2.5072452506982253e-06 / 2.1338889654131307e-06 | 0.00796357 | 14 |
| 48 | TGS1_1 | 0.0000000593 | 0.005817871625455744 / 0.001612584660708291 / 0.0053998526759721725 / 0.01862777129511709 / 0.0053998526759721725 / 0.01862777129511709 / 0.007245502894805505 / 0.0077845190703610834 / 0.006739142831934305 / 0.02903454585336941 / 0.04017463251009088 / 0.012410587219941139 / 0.022439998212103154 / 0.022439998212103154 | 1.1383417891948003e-06 / 3.9578672189598e-07 / 9.316488159288118e-07 / 1.3710585742644193e-06 / 2.6082574074268862e-06 / 1.3166677315221278e-06 / 1.7045413888506067e-06 / 3.708237186148934e-05 / 5.818012600528764e-06 / 1.560303853533272e-06 / 2.2843722976730473e-05 / 8.803523078622629e-06 / 3.9399829491464125e-06 / 3.3285882689135296e-05 | 0.014553902 | 14 |
| 49 | XG_2 | 0.0000000005 | 1.3401582342156554e-08 / 1.7203065067402312e-07 / 1.3942380334535833e-06 / 4.659755401849588e-08 / 5.207246052888057e-07 / 1.892412103400743e-05 / 1.017482106342708e-05 / 4.835640776889601e-06 / 2.3498756278510995e-06 / 1.096889887353167e-06 / 7.359704703027111e-07 / 3.633081984870721e-07 / 2.0535846739106096e-05 | 1.9199076986833634e-08 / 5.521935167514162e-09 / 3.002088015685159e-08 / 1.1673991664313873e-07 / 2.339150064869274e-07 / 7.850967660487343e-07 / 4.37609121214664e-07 / 4.313448454057681e-06 / 4.476536711400614e-06 / 4.1360359096373095e-07 / 2.1997972567339213e-06 / 1.1288300480073834e-05 / 7.933567388992601e-06 | 4.70488E-06 | 13 |
| 50 | PCDH17_2 | 0.0000000072 | 7.492219023207615e-07 / 1.6974372024295342e-05 / 1.6060512405884523e-05 / 3.680752556412065e-06 / 6.21390552863653e-07 / 6.893999398193879e-07 / 6.419532166056714e-06 / 0.00011541115360842292 / 3.212738000062656e-05 / 7.73108993011784e-06 / 0.00033397296479027066 / 2.702881264505673e-05 / 1.030767276264569e-05 | 6.224247092494593e-07 / 1.908891295970431e-06 / 1.876118975664838e-08 / 6.86071862572385e-07 / 2.666345798254567e-06 / 2.440951781485953e-06 / 1.963413625423467e-06 / 2.0652089761761355e-06 / 1.494707065464428e-06 / 8.283723353251414e-06 / 7.600283334205516e-05 / 1.3148299792014698e-05 / 1.7938478170268224e-06 | 4.39826E-05 | 13 |
| 51 | FCGRT_4 | 0.0000000001 | 1.6626318528356214e-07 / 4.1454120935946585e-08 / 1.2856777469915098e-05 / 2.655269050407992e-06 / 4.4947875774412546e-05 / 0.00076179506295693 / 8.948391869055381e-06 / 2.7424661803535043e-05 / 4.648680805728703e-06 / 1.9163242045014747e-06 / 1.4485958804049422e-06 / 2.5267554662269253e-05 / 6.405110910660664e-05 | 2.1372152215021398e-08 / 2.057088830240376e-08 / 5.269671774798225e-06 / 3.982312076585435e-06 / 2.495582032458844e-06 / 2.870333661857787e-05 / 9.483756578219822e-07 / 1.25762087754457e-05 / 9.76651146667424e-06 / 2.661769663306888e-05 / 1.3930567108132102e-05 / 1.1400150976360551e-05 / 2.349102225413189e-05 | 7.35514E-05 | 13 |
| 52 | PPAPDC2_5 | 0.0000000000 | 4.5169034086855336e-09 / 9.742548139480632e-07 / 5.217506022585185e-05 / 3.5026216529567156e-06 / 2.4673093720667337e-06 / 5.3153783898022636e-05 / 1.3937823180284198e-07 / 7.982877170487641e-08 / 6.508221395478821e-05 / 0.019956257662802263 / 6.700896966172976e-05 / 3.21116578085472e-05 / 6.01263079824308e-05 | 1.1212152252396135e-09 / 7.076208121664563e-08 / 4.726350666602277e-08 / 1.0531985708720735e-07 / 2.551343424529328e-06 / 1.7296428659338845e-05 / 2.9345983642597263e-07 / 8.883747046871617e-07 / 7.1695441364551825e-06 / 0.00011902489330085526 / 3.9052877174834575e-06 / 2.895020091940764e-06 / 9.487544302661349e-06 | 0.001561006 | 13 |
| 53 | OTUD1_1 | 0.0000066678 | 0.0001143785517442608 / 7.116374713072327e-05 / 0.0013570458512569155 / 0.002178697316418811 / 0.0038052297192277813 / 0.0007240451812165356 / 0.0019400441864677392 / 0.0023946671170695885 / 0.011483919297924996 / 0.0019400441864677392 / 0.0011976310136393364 / 8.349604404582616e-05 / 0.00782841795432341 | 2.4271728701188334e-07 / 2.716202606694871e-08 / 4.962003898295528e-07 / 1.3066402773912248e-06 / 2.94591397016505e-06 / 7.18702142240598e-07 / 1.4280279163673197e-07 / 7.547674557111806e-06 / 6.26163745905449e-06 / 6.443362593686641e-07 / 5.452589541736924e-06 / 0.00036648972212703103 / 3.720187278061506e-05 | 0.002701445 | 13 |
| 54 | IRS2_2 | 0.0000000037 | 7.220251902586713e-08 / 2.140496501618477e-08 / 1.0829140297466289e-09 / 4.1398213999064624e-06 / 1.5415033312027603e-05 / 1.1605014260398891e-06 / 3.934765724180659e-07 / 1.4279427966735553e-05 / 4.864296167501907e-07 / 2.4103457859893014e-05 / 5.7336006475198166e-05 / 5.9617084438303865e-06 | 2.2709629567530206e-06 / 2.0247353106423544e-07 / 1.3837713193741096e-07 / 1.0531985708720735e-07 / 1.1721035444282598e-06 / 5.783428499209018e-07 / 1.1344098678195103e-05 / 1.301499532725973e-06 / 8.452688032747793e-06 / 3.4078210994409503e-06 / 3.0574198226347985e-06 / 4.1558712164911445e-06 | 1.02809E-05 | 12 |
| 55 | AKAP7_1 | 0.0000000393 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 1.615375160694009e-05 / 2.0071481202007584e-05 / 5.2109649171464235e-06 / 5.1570472200670454e-05 / 2.408755304649635e-05 / 0.00025640470531776904 / 0.001077781567228248 / 0.0004073113752386311 | 1.765676819518555e-07 / 3.972296959609109e-08 / 3.2695301895520668e-06 / 1.5934388217060153e-05 / 3.721417159936691e-06 / 5.5785045280072256e-06 / 4.163536679627491e-06 / 5.719017833567702e-06 / 1.026744929609048e-05 / 2.579776719840281e-05 / 2.8764328668118886e-05 / 2.5301330015839306e-05 | 0.000155783 | 12 |
| 56 | PCMTD2_1 | 0.0000000068 | 0.0003167991900078877 / 9.289397717877934e-06 / 9.224071980226081e-07 / 3.54688199707126e-05 / 3.2501044823812903e-07 / 2.408755304649635e-05 / 2.0071481202007584e-05 / 0.0006813940301036226 / 6.979794879972793e-06 / 0.0005120167928359619 / 8.058554843717415e-06 / 0.0019333915490623197 | 5.861015607960784e-07 / 3.59230415078595e-07 / 6.529460316458851e-08 / 3.4690122473485e-07 / 8.012676260040657e-08 / 1.8059093721170035e-06 / 8.298018416641704e-07 / 9.470642017366756e-05 / 1.948928228321219e-06 / 2.3571691916825546e-06 / 2.8538696820324185e-07 / 6.729556671438922e-06 | 0.000295734 | 12 |
| 57 | ANXA11_1 | 0.0000005151 | 2.408755304649635e-05 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 9.289397717877934e-06 / 0.004410274724633273 / 3.54688199707126e-05 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 0.0019333915490623197 / 4.559947241482223e-05 / 6.979794879972793e-06 / 5.1570472200670454e-05 | 3.3435882766015197e-08 / 1.9719084534841054e-07 / 7.15064607927488e-08 / 6.417376094706333e-07 / 4.257425478509546e-06 / 1.5694978207696109e-06 / 3.888433936368708e-06 / 5.0965829347694e-07 / 3.057977557175645e-06 / 4.306237992774822e-05 / 3.6558508721641653e-06 / 2.5076660883555645e-06 | 0.000545266 | 12 |
| 58 | CYP4F22_1 | 0.0000027180 | 1.887107728600381e-05 / 0.0001432193232982916 / 0.0003242200414121999 / 0.00011602560329098725 / 0.0001432193232982916 / 0.0010434554869778357 / 0.002087197919276702 / 0.0004963923899259765 / 0.0002441254991542676 / 0.006227948945630897 / 0.00011484315511043709 / 0.00021988598115354305 | 1.855878357665062e-07 / 4.5205001853266315e-06 / 1.6230646465299277e-07 / 1.9937810791618053e-06 / 2.459173869598607e-06 / 1.418028686271357e-06 / 3.0798872921235664e-06 / 1.4638448696185004e-05 / 4.174632323174143e-06 / 6.960889474122188e-05 / 8.13226356593833e-06 / 4.0324998931408915e-06 | 0.000931617 | 12 |
| 59 | FAH_1 | 0.0000000544 | 9.971939174478468e-05 / 0.0014783442733670397 / 2.051237402337122e-05 / 1.1263759452799203e-06 / 1.7999540459370774e-05 / 0.005398390884784092 / 0.0002944288613709527 / 0.0026702661426604127 / 0.0028963504457353837 / 0.0008619933402586612 / 0.0028963504457353837 / 0.0001395680222164631 | 1.0046436835312793e-07 / 3.154681248422513e-08 / 5.394104603263994e-07 / 2.7366646890842144e-07 / 5.480720006502052e-08 / 1.6335104962830753e-06 / 1.8420227314596207e-06 / 7.083329258820255e-06 / 2.102391157291273e-06 / 1.7455247460827437e-06 / 0.00019992317018209673 / 1.9765391249129614e-06 | 0.001397921 | 12 |
| 60 | PRSS35_1 | 0.0000001503 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 2.408755304649635e-05 / 4.0242980256377906e-05 / 0.011066537502725836 / 0.017443989828652796 | 2.153587369784463e-08 / 1.0035560526801471e-07 / 1.5112245406129175e-07 / 8.734069561342572e-09 / 6.456193736055655e-07 / 1.1915844331577668e-07 / 1.2496790707220447e-06 / 5.187593428631375e-06 / 7.677479865507362e-06 / 4.694603023798112e-06 / 2.4926729322946157e-05 / 6.095320536599329e-05 | 0.002384904 | 12 |
| 61 | ARID2_1 | 0.0000000008 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 5.1570472200670454e-05 / 1.3062838211579366e-05 / 2.7109747094287326e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 6.979794879972793e-06 / 2.408755304649635e-05 / 3.54688199707126e-05 | 1.4085604923353669e-09 / 2.1559634977578997e-08 / 3.073451224470281e-08 / 6.67627891847618e-07 / 9.45287179820993e-07 / 1.6026605078229915e-06 / 2.8723110644674783e-07 / 6.593293352572093e-08 / 1.76044274336364e-06 / 2.2796504010207573e-06 / 4.083275206575873e-06 | 1.52054E-05 | 11 |
| 62 | GBE1_2 | 0.0000000002 | 1.0829140297466289e-09 / 1.1605014260398891e-06 / 2.140496501618477e-08 / 2.4103457859893014e-05 / 1.3483681400210042e-06 / 6.882770012055959e-06 / 3.539399887995572e-05 / 4.926323640851737e-05 / 4.864296167501907e-07 / 5.7336006475198166e-05 / 4.1398213999064624e-06 | 6.14215099741482e-11 / 8.633691649398072e-08 / 3.1558675335691306e-07 / 6.649001393280087e-07 / 1.5766900825696111e-06 / 4.000342337039938e-06 / 2.5158332022026807e-06 / 1.3914120255170465e-05 / 3.7817976979062494e-06 / 3.526532094488005e-06 / 1.4262192253107675e-06 | 1.63761E-05 | 11 |
| 63 | FEZF1_2 | 0.0000000048 | 2.140496501618477e-08 / 1.0829140297466289e-09 / 1.5415033312027603e-05 / 0.0006617980305097352 / 3.934765724180659e-07 / 4.864296167501907e-07 / 3.539399887995572e-05 / 7.220251902586713e-08 / 1.1605014260398891e-06 / 1.3483681400210042e-06 / 2.4103457859893014e-05 | 3.290701334443236e-08 / 5.517282972397794e-07 / 2.461670483939178e-07 / 3.7377331388541626e-05 / 5.142883274641414e-06 / 4.043272115285976e-06 / 2.938617309558263e-05 / 4.8239179614945364e-05 / 7.309372974198873e-06 / 1.022853119829971e-05 / 2.3639654167207866e-05 | 6.72904E-05 | 11 |
| 64 | ACACB_2 | 0.0000000003 | 2.135362618124217e-07 / 2.2402150648537843e-08 / 3.983245164121986e-08 / 4.136645421698625e-06 / 3.025796797872868e-08 / 0.0005588402339511055 / 8.584401402568793e-06 / 1.471749614726362e-06 / 0.0003892038851689398 / 3.8987044705871713e-07 / 8.994816753298524e-06 | 1.3484124764189522e-08 / 4.706709396786997e-07 / 9.271074896090571e-07 / 5.302698252478667e-06 / 2.0500342574990374e-06 / 1.551726788306523e-06 / 1.781550905952925e-05 / 7.047194494372442e-06 / 1.9709880947249853e-06 / 5.20649578902775e-06 / 1.1244039336708898e-05 | 8.83571E-05 | 11 |
| 65 | CUX2_1 | 0.0000000906 | 0.0001432193232982916 / 1.887107728600381e-05 / 0.0003935478447180597 / 0.00033206653362091303 / 0.00021988598115354305 / 0.0001432193232982916 / 0.0007228851823325908 / 0.00036719870368562404 / 0.00011484315511043709 / 0.00011602560329098725 / 0.0004963923899259765 | 1.1673991664313873e-07 / 1.284325373822431e-07 / 1.6698077738985942e-06 / 6.902441910511023e-07 / 3.4215164228215663e-07 / 3.007835341834974e-06 / 1.919682119213592e-06 / 1.5381709053459223e-06 / 3.6946271417190457e-06 / 6.898390776268342e-06 / 6.529025230777642e-06 | 0.000278923 | 11 |
| 66 | H2AFY2_1 | 0.0000000422 | 0.0008581803853921776 / 1.1263759452799203e-06 / 2.051237402337122e-05 / 0.0031060111248571412 / 0.0005345324666238675 / 0.0001395680222164631 / 4.369070707050029e-05 / 9.971939174478468e-05 / 0.0003301911422383287 / 0.006072266622156599 / 0.0002944288613709527 | 5.135300319990053e-08 / 7.661142091219907e-10 / 7.618409522067726e-07 / 1.0083404706814497e-06 / 8.282189290342112e-07 / 1.147296721987914e-06 / 5.029041750177964e-07 / 2.8221672702900553e-06 / 6.87678977620866e-06 / 1.6817202963510347e-06 / 1.5631172248405328e-05 | 0.001045475 | 11 |
| 67 | SCNN1G_1 | 0.0000000555 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 6.979794879972793e-06 / 0.017443989828652796 / 2.0071481202007584e-05 / 5.2109649171464235e-06 / 0.0006200425273220967 / 9.224071980226081e-07 / 9.289397717877934e-06 / 5.2109649171464235e-06 | 1.613539402686862e-07 / 3.7316428195760516e-08 / 6.371651336534961e-07 / 1.237673510094506e-06 / 6.701672901978117e-05 / 1.972791863813969e-06 / 1.1012098448593559e-06 / 1.967576698919758e-06 / 4.9444208073750495e-06 / 1.3324922817800096e-05 / 3.1007051507707384e-05 | 0.001646658 | 11 |
| 68 | MICAL2_1 | 0.0000002288 | 0.00049387566368266 / 8.019236578134864e-05 / 0.004971246918927329 / 0.004078510310946084 / 0.0004290110230937398 / 0.00043106377145357623 / 0.0006315592529035093 / 0.001914379403049941 / 0.0034656404808317003 / 0.0025176594807100345 / 0.00031707617750638764 | 2.1762204790117787e-09 / 3.2272833090138044e-07 / 7.827762172740352e-08 / 6.06643046842526e-08 / 1.3129367317358875e-07 / 4.830225730426315e-07 / 3.928902637745179e-07 / 3.9101702420209316e-06 / 9.84639797132252e-07 / 6.086458081584004e-07 / 2.1279294679682064e-06 | 0.001757292 | 11 |
| 69 | SWT1_2 | 0.0000000170 | 2.9659818641279015e-06 / 0.00029176699231122706 / 1.5046470240543167e-06 / 0.004644223206500837 / 0.010900569633432996 / 2.7522055206568103e-06 / 0.00013583448483780612 / 0.004741348922243877 / 0.0003486124797281799 / 7.371030323660905e-05 / 0.00018181245959759176 | 4.9187331773462e-08 / 2.5012881769902937e-08 / 6.268977803019969e-07 / 1.3528096310298506e-06 / 2.783451231831402e-06 / 2.565078990567409e-07 / 8.86664377274927e-07 / 5.964528017547677e-07 / 6.174004769239488e-07 / 9.308945080733071e-06 / 1.0484586327302643e-05 | 0.001938646 | 11 |
| 70 | PDE6B_1 | 0.0000013889 | 1.228676574562544e-05 / 0.0011323441860117745 / 8.807499017205126e-05 / 0.002107325343692074 / 0.0014854545690578267 / 0.019751746709410014 / 0.004410274724633273 / 0.005133998810813905 / 0.0020170234515396526 / 0.004410274724633273 / 0.0016232581034909483 | 5.065661868983875e-07 / 7.17995131525044e-07 / 4.053723016913819e-06 / 8.937583768343871e-07 / 1.1790960971280032e-06 / 4.154079216411671e-06 / 1.726041894379202e-05 / 1.0279309246897823e-05 / 0.0003143462985658359 / 8.736287586605331e-06 / 6.384516835905964e-05 | 0.003833824 | 11 |
| 71 | FUT11_4 | 0.0000000000 | 6.74235053631547e-08 / 4.771768758103407e-07 / 3.1959674906838326e-06 / 1.3575216074689785e-06 / 1.8241579597627434e-05 / 8.479913437625553e-06 / 8.284064752711457e-06 / 0.00018644210000651158 / 5.006828327534464e-05 / 8.236105425032711e-06 | 2.4685536420123714e-08 / 4.05022735179046e-08 / 8.733965575196973e-08 / 1.3604574320151334e-07 / 8.805480517015095e-07 / 2.385334687979164e-07 / 4.9124234903367736e-06 / 9.92600195563702e-06 / 3.057977557175645e-06 / 1.118638923657507e-06 | 2.8485E-05 | 10 |
| 72 | CRMP1_2 | 0.0000000000 | 2.0535846739106096e-05 / 1.3401582342156554e-08 / 2.225580423517811e-06 / 1.3942380334535833e-06 / 0.00024560379848655926 / 4.659755401849588e-08 / 2.1627385395830295e-05 / 3.633081984870721e-07 / 3.4192931304829014e-06 / 0.0006879396808549597 | 7.620811819896486e-06 / 4.382658462880079e-06 / 1.3863143636682347e-05 / 1.3319999198783528e-06 / 1.2152438530817433e-05 / 4.382658462880079e-06 / 8.241971999095359e-06 / 9.923377128421226e-06 / 6.249002717536056e-06 / 5.602552813683701e-05 | 9.83169E-05 | 10 |
| 73 | ATP2B3_2 | 0.0000000043 | 0.0003163773097135214 / 7.172518710454511e-06 / 7.245191987655973e-05 / 8.741819060152168e-05 / 5.359794419137135e-05 / 4.430782193013355e-05 / 0.00023847763377654726 / 4.824032561244295e-06 / 4.5251992585881006e-07 / 0.0004949659728438359 | 2.4865375915662647e-06 / 1.5062494177669247e-06 / 1.688540465706646e-06 / 1.6196306143315863e-06 / 2.748486185526218e-07 / 2.086193436943505e-05 / 2.6861282329371614e-06 / 5.547613575367754e-06 / 3.303970125073177e-05 / 1.1524582203343819e-05 | 0.000132005 | 10 |
| 74 | KLHL23_2 | 0.0000000192 | 6.893999398193879e-07 / 6.419532166056714e-06 / 2.702881264505673e-05 / 6.21390552863653e-07 / 0.0017884623559603927 / 1.6974372024295342e-05 / 0.001013875347197311 / 7.396819433180742e-05 / 0.0005052900676961513 / 7.73108993011784e-06 | 4.968239365259682e-09 / 1.7135370925414656e-07 / 2.932867120091765e-07 / 3.3425571794650135e-07 / 3.0548311202804935e-06 / 3.451257716664588e-06 / 2.1699721245824695e-06 / 4.163536679627491e-06 / 2.920396755301379e-05 / 6.218195828657096e-06 | 0.000344106 | 10 |
| 75 | PNMAL1_1 | 0.0000000001 | 9.224071980226081e-07 / 9.289397717877934e-06 / 3.54688199707126e-05 / 8.058554843717415e-06 / 2.408755304649635e-05 / 2.7109747094287326e-07 / 4.491442887170463e-06 / 3.54688199707126e-05 / 0.003763661611010697 / 2.0071481202007584e-05 | 2.398130659400807e-08 / 3.3728825978612466e-08 / 2.556768800894887e-07 / 1.098753545263955e-07 / 8.352881705441376e-07 / 4.562304305269522e-07 / 1.08096832891062e-06 / 1.1362044976111473e-06 / 3.965156059753076e-06 / 2.532544882586065e-07 | 0.000390179 | 10 |
| 76 | DPP9_1 | 0.0000000903 | 0.0001432193232982916 / 0.009103599585178113 / 0.001710012299865077 / 0.00011602560329098725 / 0.0004963923899259765 / 0.0002441254991542676 / 1.887107728600381e-05 / 0.00021988598115354305 / 0.00033206653362091303 / 0.00011484315511043709 | 2.8179456082348394e-09 / 2.727075953865357e-06 / 1.168813758935927e-06 / 3.371222633783479e-08 / 4.426276839356633e-07 / 7.736320976296901e-08 / 1.0399111877082387e-07 / 5.1926198984756595e-08 / 2.443030575808895e-07 / 5.2490814290897396e-08 | 0.001249904 | 10 |
| 77 | GPC2_1 | 0.0000011913 | 0.00038318838044808375 / 0.0005893191501630695 / 0.00015165886425239433 / 0.0001877376372184388 / 7.79155859315203e-05 / 3.4006794328894204e-05 / 9.771266164691155e-05 / 0.0021345675385303783 / 0.009896861713608592 / 0.00046672125625950257 | 5.8322357175018814e-08 / 3.819394841783607e-06 / 4.185755315703245e-06 / 8.9047725673033e-06 / 1.688540465706646e-06 / 1.3977429686239098e-06 / 7.632716224230066e-06 / 2.3986226430486996e-06 / 8.321983027984269e-05 / 1.1589901935051875e-05 | 0.001401969 | 10 |
| 78 | RBM27_1 | 0.0000328921 | 0.00019056149396649567 / 1.0762691116666793e-05 / 0.00016655530309410099 / 0.00014532888285824017 / 0.008666672397448167 / 0.0011926586521531122 / 8.547883129077166e-06 / 0.0005615344938163923 / 0.0009516879673421394 / 0.008666672397448167 | 3.272103105129996e-05 / 6.146543343371357e-05 / 3.6952686083686934e-05 / 1.4957676302550525e-05 / 0.00044169721387816736 / 0.0002538625473566664 / 6.352688846998858e-05 / 0.00045432042455129443 / 0.0011408393624126037 / 4.513400088366357e-05 | 0.002056098 | 10 |
| 79 | HOXD13_1 | 0.0000000916 | 2.7109747094287326e-07 / 3.2501044823812903e-07 / 3.1219185299958266e-05 / 0.0027465190930067913 / 0.017443989828652796 / 0.016412811603890378 / 9.224071980226081e-07 / 0.0006813940301036226 / 5.2109649171464235e-06 / 9.289397717877934e-06 | 1.1132672619587453e-06 / 2.168405947503928e-06 / 8.632653046332761e-07 / 2.661765393750704e-07 / 2.9706339258865287e-05 / 9.772801528529325e-07 / 6.119157345497534e-06 / 4.403524887759186e-05 / 3.9616874289254276e-05 / 1.5034368122270238e-05 | 0.003733195 | 10 |
| 80 | TFCP2_1 | 0.0000155106 | 0.0032558342640986913 / 0.003164163749771866 / 0.007834759439000943 / 0.0006574116836031526 / 0.0004120327968848806 / 0.002547330192150467 / 0.023671720746870278 / 0.01008298563196674 / 0.003825348546364798 / 0.012865293420775923 | 1.7408199559491215e-08 / 3.662770588769913e-08 / 2.4230602059049713e-09 / 7.057607420139844e-09 / 5.864919427085214e-09 / 4.067269852743229e-09 / 1.2958775867702838e-07 / 2.4061415002001486e-07 / 1.04445857509862e-08 / 8.406826338931904e-09 | 0.006831688 | 10 |
| 81 | MLC1_2 | 0.0000000000 | 2.3317798357459768e-08 / 3.950726068803937e-05 / 7.200240759113992e-08 / 6.485065795284483e-06 / 2.72061163246224e-07 / 1.0914465968113564e-09 / 8.785255275890593e-07 / 2.260908840956264e-06 / 3.4091273206128115e-06 | 3.821355197181773e-10 / 4.815234643922553e-08 / 4.880618111292151e-07 / 6.535686301472137e-07 / 5.01553847742357e-09 / 9.071527094231567e-07 / 1.561363617000177e-06 / 3.5739771593065375e-08 / 6.799019141310347e-07 | 5.87882E-06 | 9 |
| 82 | NUDT10_1 | 0.0000000252 | 5.2109649171464235e-06 / 2.0071481202007584e-05 / 1.3062838211579366e-05 / 5.2109649171464235e-06 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 6.979794879972793e-06 / 4.559947241482223e-05 | 8.543772901530404e-08 / 3.0560088249163646e-06 / 3.4630204183867344e-06 / 1.75703491771623e-06 / 8.596645616376963e-06 / 6.6659679642121145e-06 / 6.998717296179836e-06 / 6.1225414982440546e-06 / 6.176627272024636e-05 | 1.57573E-05 | 9 |
| 83 | ABHD6_5 | 0.0000000011 | 3.358358494818591e-05 / 2.9134927252228483e-07 / 2.9938150702443185e-06 / 2.052332708446901e-06 / 1.4490238008299036e-06 / 3.2017228485917034e-06 / 7.134949223903302e-05 / 9.16995079558899e-05 / 3.381829650307869e-05 | 1.889438601616299e-06 / 1.2766781385500044e-06 / 2.363524198350829e-06 / 3.917011825001329e-06 / 7.303755032082717e-06 / 1.3315374780889495e-05 / 2.4860974232140882e-05 / 1.6960856788042183e-05 / 1.807142776332772e-05 | 2.67155E-05 | 9 |
| 84 | NDST4_2 | 0.0000000040 | 2.668064610627935e-06 / 6.6526771052306895e-06 / 1.1230314579614556e-05 / 1.8473033200489925e-05 / 6.627915836434039e-07 / 8.256090054064686e-05 / 1.116884259988551e-05 / 5.25757451328789e-05 / 9.075192641901149e-05 | 9.235058235332018e-08 / 3.739290293217579e-07 / 8.778520319265194e-07 / 4.805213523603749e-07 / 9.024033737327827e-06 / 1.2463662086892492e-06 / 2.593919669520066e-06 / 1.5869215394518834e-05 / 6.9327764685965786e-06 | 3.07494E-05 | 9 |
| 85 | POU3F2_5 | 0.0000000000 | 7.323883195296019e-07 / 5.815521557860219e-06 / 1.9482696423142906e-05 / 0.0007454381092335746 / 1.161047392436168e-05 / 1.810779009958944e-06 / 4.647086083767663e-06 / 1.4526839867076841e-05 / 3.820854417705018e-05 | 4.118783678942697e-07 / 1.9018218973456198e-06 / 5.1834489629063885e-06 / 0.00016912370949213852 / 1.1280051635983909e-05 / 3.251853365907979e-06 / 6.769433778371573e-06 / 2.785132091011529e-05 / 7.035159184655411e-05 | 9.35858E-05 | 9 |
| 86 | RND2_1 | 0.0000002063 | 3.2501044823812903e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 2.408755304649635e-05 / 0.0003167991900078877 / 9.289397717877934e-06 / 9.224071980226081e-07 / 0.0006200425273220967 / 0.0019333915490623197 | 4.692355741850912e-08 / 3.057428987575251e-08 / 1.287838376941801e-06 / 6.249875151319963e-07 / 2.5823199743834396e-06 / 2.0615635366014647e-06 / 1.0191814256901842e-06 / 1.8943189562108068e-06 / 2.0339342639032117e-05 | 0.000325095 | 9 |
| 87 | TEKT2_1 | 0.0000012269 | 3.2501044823812903e-07 / 0.00299921656722761 / 2.7109747094287326e-07 / 6.979794879972793e-06 / 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 0.0019333915490623197 | 2.626807545548127e-07 / 8.972858217500653e-07 / 8.188038459526457e-05 / 1.2353713533928581e-05 / 4.657480324879461e-05 / 6.734781530483014e-06 / 3.917368514292802e-05 / 4.398198496660895e-05 / 3.85813042649088e-05 | 0.000552853 | 9 |
| 88 | RCOR1_1 | 0.0000002629 | 0.0035374364838401885 / 0.0005794708000429308 / 0.004598611207763406 / 0.00027838639004009185 / 0.00254170936910902 / 0.0007730790428095843 / 0.0008116048904747243 / 0.00028760490535839194 / 0.0006209741142612609 | 2.12095972377237e-08 / 5.371804546576567e-07 / 1.3631627975922064e-06 / 1.3930567108132102e-05 / 7.320109762709196e-06 / 3.5012227758823163e-06 / 9.972925901562962e-06 / 5.848283608879877e-06 / 1.9939940203933426e-05 | 0.001558764 | 9 |
| 89 | SH3GLB1_1 | 0.0000001142 | 1.1263759452799203e-06 / 0.0002944288613709527 / 1.7999540459370774e-05 / 0.009181416163184238 / 0.0001249119186090808 / 0.001133267650419163 / 0.0026702661426604127 / 0.005398390884784092 / 0.00014547367344876742 | 5.021137237572428e-08 / 1.412114735889678e-07 / 2.6082574074268862e-06 / 2.1694530129992346e-06 / 2.622668544008386e-06 / 1.3863143636682347e-05 / 2.2950455177001124e-05 / 8.882430105407664e-06 / 8.761908558227523e-06 | 0.002107476 | 9 |
| 90 | ZCCHC5_1 | 0.0000003387 | 0.0002944288613709527 / 0.004641723683002966 / 0.00036105139567184824 / 0.0036790499750236597 / 0.0005345324666238675 / 0.0021653473543332357 / 0.0067509647795811235 / 0.0033178709219427965 / 0.0001395680222164631 | 2.1634030409586368e-05 / 1.0447439952129488e-05 / 4.841492876651217e-06 / 8.425020418700623e-06 / 1.7550566576642783e-06 / 1.829374010437789e-05 / 0.00016237480333105512 / 2.4267895369009183e-05 / 1.021655106614923e-05 | 0.002431615 | 9 |
| 91 | EVI2B_1 | 0.0000000810 | 0.0005654433700885616 / 0.0021345675385303783 / 0.0010514734188248587 / 0.01706732677471782 / 0.00016882475928990226 / 0.0017046060667733898 / 1.7173658335771082e-06 / 0.0010760707198761224 / 0.01365229997365103 | 4.967070750533046e-07 / 9.339254057047784e-06 / 2.37004080182631e-05 / 1.7573172310813478e-05 / 4.067330085914587e-07 / 1.0577974069325492e-06 / 9.173510310512699e-06 / 1.887257789753108e-05 / 6.115093766942535e-05 | 0.004158037 | 9 |
| 92 | EPC1_2 | 0.0000000072 | 0.0034390541604176214 / 0.0002448208689788285 / 0.01617199881991826 / 0.02211371791626479 / 0.0025035638269418226 / 0.01851025775546256 / 0.006305703578524486 / 0.00515664879236201 / 0.009067920198647179 | 5.695617165978249e-07 / 1.1672960349256724e-07 / 2.840596912722915e-06 / 6.081404109618168e-06 / 2.4211525355218317e-06 / 1.1016073014221325e-05 / 1.0934695006353887e-05 / 4.4117963688512546e-05 / 2.106616906903645e-05 | 0.009279298 | 9 |
| 93 | VAX1_2 | 0.0000000005 | 1.3401582342156554e-08 / 4.659755401849588e-08 / 4.835640776889601e-06 / 7.359704703027111e-07 / 1.096889887353167e-06 / 1.3942380334535833e-06 / 5.207246052888057e-07 / 3.4192931304829014e-06 | 7.755118664932962e-08 / 9.171116579440387e-08 / 1.1013084399854174e-05 / 4.524910966526263e-06 / 1.529385415217493e-06 / 1.427223677524831e-05 / 1.4066320814267013e-05 / 2.2774582231147903e-05 | 1.50784E-06 | 8 |
| 94 | DLG2_3 | 0.0000000002 | 7.813308929582946e-09 / 1.6547061876174137e-09 / 1.3841014381780992e-08 / 3.911794473620475e-08 / 3.925563562928499e-06 / 1.0025262671531361e-05 / 1.4592559377242048e-06 / 7.203525855071736e-08 | 5.333355940483967e-07 / 2.493514693804668e-05 / 1.3553742801395556e-05 / 2.784723823441103e-05 / 0.00031844709703193725 / 3.540970687955017e-05 / 4.292537092544752e-05 / 4.4176636548796324e-05 | 1.94307E-06 | 8 |
| 95 | PPP1R1A_2 | 0.0000000058 | 6.21390552863653e-07 / 6.893999398193879e-07 / 7.492219023207615e-07 / 2.702881264505673e-05 / 3.680752556412065e-06 / 1.6060512405884523e-05 / 7.73108993011784e-06 / 6.419532166056714e-06 | 2.1597799174876656e-06 / 1.9305294911280603e-06 / 5.352949078223872e-06 / 6.799175330608916e-06 / 8.452688032747793e-06 / 1.5945569790774137e-05 / 3.22477346098806e-05 / 2.984896137178954e-05 | 7.87259E-06 | 8 |
| 96 | EFNB1_1 | 0.0000000276 | 2.7109747094287326e-07 / 6.979794879972793e-06 / 9.224071980226081e-07 / 4.0242980256377906e-05 / 3.2501044823812903e-07 / 0.0004073113752386311 / 5.2109649171464235e-06 / 4.559947241482223e-05 | 2.1957511801277782e-07 / 4.889428996554765e-08 / 2.1248474074975664e-07 / 1.7135370925414656e-07 / 3.884450294793579e-06 / 5.591633483860606e-06 / 1.8857958946421756e-06 / 2.8107942340015973e-05 | 6.33579E-05 | 8 |
| 97 | POU3F1_2 | 0.0000000002 | 1.0829140297466289e-09 / 2.140496501618477e-08 / 0.0006617980305097352 / 3.539399887995572e-05 / 1.1605014260398891e-06 / 4.1398213999064624e-06 / 4.864296167501907e-07 / 1.3483681400210042e-06 | 6.030358521257982e-09 / 1.7387409176294374e-08 / 5.254390767028075e-06 / 2.543218750177778e-06 / 1.6396573544351217e-06 / 8.529464444824402e-07 / 6.695092024209846e-06 / 8.770352824154869e-06 | 8.80437E-05 | 8 |
| 98 | JPH1_2 | 0.0000000087 | 5.556780192800504e-08 / 2.0874526624748995e-06 / 0.0012644399858917665 / 4.607960729596523e-06 / 2.1738520362230936e-05 / 1.6503521660931074e-06 / 2.1738520362230936e-05 / 0.00015574282021503215 | 3.4277179006258406e-08 / 1.490529071824182e-08 / 3.286947652963165e-05 / 8.194195146930721e-06 / 2.1888678883833245e-05 / 2.6787516426543844e-06 / 1.2909385190385643e-05 / 1.5296407537085686e-05 | 0.000184008 | 8 |
| 99 | LGALS3_5 | 0.0000000000 | 0.0003565042040229888 / 9.438944028750308e-06 / 9.04485841302387e-07 / 1.6632151970584391e-06 / 3.410158051548764e-05 / 0.0003318801877935931 / 0.0012804486516771864 / 0.00021733046754869307 | 6.677920897376901e-06 / 2.6764509283677262e-06 / 1.8682268381796687e-06 / 7.156112560189961e-06 / 5.102936564089435e-05 / 1.756292794705785e-05 / 9.025855388190028e-05 / 1.637569955003e-05 | 0.000279034 | 8 |
| 100 | LRRC4B_1 | 0.0000002709 | 1.887107728600381e-05 / 0.0005437871552770366 / 0.0001432193232982916 / 0.00011602560329098725 / 0.00021988598115354305 / 0.0007228851823325908 / 0.002087197919276702 / 0.0004963923899259765 | 5.474742848216316e-08 / 7.540000372679234e-08 / 2.4324836459725464e-07 / 1.1863961735006869e-06 / 1.582805196129757e-06 / 3.4634781029298443e-06 / 3.0574198226347985e-06 / 7.803003903662519e-07 | 0.000543533 | 8 |
| 101 | ARHGAP19_1 | 0.0000004900 | 1.1263759452799203e-06 / 0.0002944288613709527 / 2.051237402337122e-05 / 0.00014547367344876742 / 0.0003301911422383287 / 0.0001395680222164631 / 0.0026702661426604127 / 0.006072266622156599 | 8.088262923201297e-10 / 5.32512126526287e-09 / 8.298236021731966e-08 / 3.5084952233067013e-07 / 2.3265577637109093e-06 / 1.1001720936904985e-06 / 3.6392711556668255e-06 / 1.2562017250662189e-06 | 0.001209229 | 8 |
| 102 | MYL9_1 | 0.0000000778 | 9.224071980226081e-07 / 5.2109649171464235e-06 / 2.7109747094287326e-07 / 1.3062838211579366e-05 / 9.289397717877934e-06 / 5.2109649171464235e-06 / 3.2501044823812903e-07 | 2.459173869598607e-06 / 3.652101302901246e-06 / 1.2972527217084128e-05 / 8.597378090854104e-06 / 5.7833188092788925e-06 / 1.4022276300344631e-05 / 2.145854408813797e-06 | 4.89895E-06 | 7 |
| 103 | TMEM170B_1 | 0.0000002606 | 9.289397717877934e-06 / 9.224071980226081e-07 / 3.2501044823812903e-07 / 2.0071481202007584e-05 / 4.559947241482223e-05 / 2.408755304649635e-05 / 5.2109649171464235e-06 | 1.9697921819906958e-07 / 3.165978824218861e-07 / 2.2816438659720932e-06 / 2.742836199391347e-06 / 6.990510977409468e-05 / 2.9323575212698406e-06 / 8.993575247920803e-05 | 1.50723E-05 | 7 |
| 104 | CSAD_1 | 0.0000002822 | 5.2109649171464235e-06 / 3.54688199707126e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.54688199707126e-05 / 2.0071481202007584e-05 / 6.979794879972793e-06 | 6.111203426085803e-07 / 2.171879517260808e-06 / 5.854820901741727e-07 / 7.835058995288738e-07 / 2.7557290434491165e-06 / 6.817652862377265e-07 / 1.2092985656812561e-05 | 1.62017E-05 | 7 |
| 105 | ASGR1_5 | 0.0000000000 | 1.1623489088470996e-07 / 3.721066145469274e-07 / 3.333239304736607e-06 / 2.1608013080506192e-07 / 3.230485829869497e-05 / 8.060189282236343e-06 / 8.676969132083257e-05 | 7.305647078744524e-09 / 5.144455443656822e-07 / 1.4357703259269896e-06 / 1.2509260043210937e-08 / 5.934720152286974e-06 / 2.2212849303091722e-05 / 1.856219255522198e-05 | 1.87389E-05 | 7 |
| 106 | KIAA1958_1 | 0.0000014113 | 9.224071980226081e-07 / 3.2501044823812903e-07 / 9.289397717877934e-06 / 2.0071481202007584e-05 / 0.00029640089162746337 / 1.3062838211579366e-05 / 2.408755304649635e-05 | 1.7837147826607992e-06 / 6.377999497501375e-07 / 6.986597395696305e-07 / 2.0980658004722796e-06 / 1.9921322770288805e-06 / 1.773331235256366e-05 / 5.3250557763788615e-06 | 5.20228E-05 | 7 |
| 107 | NPW_2 | 0.0000000041 | 3.24920563754477e-05 / 1.6676618048371524e-06 / 3.349324237754571e-06 / 0.00026033133118006545 / 2.8198901661861037e-07 / 1.3377106429420062e-05 / 0.00015487870247863725 | 1.1216334102038042e-05 / 3.795870398901593e-05 / 2.789700527592356e-05 / 2.4370350557859375e-05 / 2.383281576252229e-06 / 1.739637519533283e-05 / 4.995051896804675e-05 | 6.66255E-05 | 7 |
| 108 | CAP1_1 | 0.0000001084 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 5.1570472200670454e-05 / 0.0006813940301036226 / 1.615375160694009e-05 | 2.3269670797546372e-09 / 2.178989287248064e-07 / 1.5690808649462252e-07 / 2.2812382420261574e-07 / 5.003267757352306e-07 / 5.854077230406485e-06 / 3.5713716118086355e-06 | 0.000111963 | 7 |
| 109 | SIAH3_1 | 0.0000003288 | 2.7109747094287326e-07 / 9.224071980226081e-07 / 9.289397717877934e-06 / 2.408755304649635e-05 / 3.2501044823812903e-07 / 1.615375160694009e-05 / 0.0019333915490623197 | 6.049342679130285e-07 / 8.815712638887937e-06 / 4.740549194395327e-06 / 9.480468782335477e-06 / 1.5820053502878103e-05 / 6.463404069739772e-06 / 1.6126637325555423e-05 | 0.000283492 | 7 |
| 110 | PALM3_1 | 0.0000000299 | 1.1263759452799203e-06 / 0.00014547367344876742 / 0.0002944288613709527 / 6.267778266652492e-05 / 0.00036105139567184824 / 4.369070707050029e-05 / 0.0012393227037226365 | 1.61127559567575e-08 / 5.017834401276047e-07 / 3.661929862620404e-06 / 1.2173443563611742e-05 / 1.1966193354414176e-05 / 2.4195118600922182e-05 / 1.7243254719929916e-05 | 0.000306824 | 7 |
| 111 | STMN3_1 | 0.0000000026 | 7.246316173948605e-05 / 3.547654313435299e-05 / 0.0009373528710364089 / 0.0006480090460888989 / 0.0006480090460888989 / 0.0006480090460888989 / 0.0003279301515605841 | 7.322406775875832e-06 / 8.942892958849265e-06 / 1.807142776332772e-05 / 2.509219654843992e-05 / 1.8505484636417077e-05 / 3.37731892462157e-05 / 9.285668025091915e-06 | 0.000473893 | 7 |
| 112 | TMEM81_1 | 0.0000008765 | 5.273896379563962e-05 / 6.356656086987109e-05 / 0.00043134694416039135 / 0.00013546030217733798 / 0.0004059772887267331 / 0.0023391751758116753 / 0.00032373731095170963 | 1.0787679920477812e-07 / 2.5789707372412023e-07 / 2.2840059569727543e-06 / 3.5876629179259e-06 / 1.224552952677817e-05 / 1.3699807790719473e-05 / 0.00010021610177229421 | 0.000536 | 7 |
| 113 | SPATA6L_2 | 0.0000000000 | 6.561438181488045e-08 / 0.0039060792371246288 / 1.2713340125393577e-06 / 4.9709559427158936e-05 / 2.9984630262222775e-05 / 2.5044323053359897e-05 / 0.0003189222745634422 | 1.1928730580085498e-07 / 1.6308994378745635e-05 / 7.252465307108788e-07 / 4.675129100784084e-05 / 2.4918595616148034e-05 / 1.2527391630040111e-05 / 0.00035139543234848433 | 0.000618725 | 7 |
| 114 | CSRP2BP_5 | 0.0000000001 | 0.0010693215114176687 / 0.0005366621924321155 / 5.114637961482107e-05 / 0.001965268902490897 / 0.0006502221049801445 / 1.6105294963590637e-05 / 0.0010730574005743563 | 3.1276785123692046e-07 / 9.71112422824034e-07 / 6.485117187559721e-06 / 9.024033737327827e-06 / 2.832326930093088e-06 / 4.687104252350739e-07 / 1.9659786069911358e-05 | 0.000765969 | 7 |
| 115 | MAP2K6_1 | 0.0000003962 | 0.00049387566368266 / 0.001914379403049941 / 0.0025176594807100345 / 0.0006315592529035093 / 0.0034656404808317003 / 0.00043106377145357623 / 0.004971246918927329 | 1.1930754029013138e-06 / 8.239304675009157e-06 / 9.456559403963851e-07 / 1.224552952677817e-05 / 1.1431401687645685e-05 / 4.3734040668837504e-05 / 2.2586038013431965e-05 | 0.002060775 | 7 |
| 116 | HOXB13_1 | 0.0000005163 | 3.2501044823812903e-07 / 0.011066537502725836 / 9.289397717877934e-06 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 0.017443989828652796 / 1.615375160694009e-05 | 2.2857725793381497e-08 / 6.58231193542836e-07 / 9.335221622816497e-07 / 5.9574734192841e-07 / 9.009609250490209e-07 / 6.752637204404786e-06 / 6.717516905544411e-06 | 0.004079613 | 7 |
| 117 | RBM12B_1 | 0.0000027010 | 0.04720120118838744 / 0.01326934306028551 / 0.016928162681653376 / 0.031078733529297287 / 0.002048221708938053 / 0.0034110277620841853 / 0.0010661050941684071 | 2.1680661197087e-06 / 2.9189015908569146e-07 / 1.1699094105987198e-06 / 7.252465307108788e-07 / 7.978099824844419e-07 / 9.884000914674844e-06 / 2.094766018419809e-07 | 0.016428971 | 7 |
| 118 | ADRB3_1 | 0.0000000110 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.7109747094287326e-07 / 2.0071481202007584e-05 / 9.289397717877934e-06 / 9.224071980226081e-07 | 4.241171654391019e-07 / 1.460759694934436e-06 / 1.0275041110630902e-05 / 2.951788675228993e-05 / 2.7256307870565235e-06 / 1.7536333634491446e-06 | 5.3003E-06 | 6 |
| 119 | LUC7L_5 | 0.0000000000 | 4.893976636572636e-08 / 4.301553480101108e-06 / 1.9454781373606418e-07 / 2.401972521996653e-06 / 2.7416809858149543e-05 / 2.126445195983224e-06 | 9.243344747900569e-10 / 5.575865427598105e-07 / 7.332853758502689e-07 / 1.804034226196658e-06 / 3.3436666464536245e-05 / 5.494452455047808e-06 | 6.08171E-06 | 6 |
| 120 | ITM2A_1 | 0.0000000846 | 2.7109747094287326e-07 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 / 4.0242980256377906e-05 | 9.57143021581257e-08 / 2.3530982511650296e-08 / 9.277238538824435e-08 / 9.772375417317643e-08 / 7.542510909686565e-07 / 5.344419818471506e-07 | 8.99204E-06 | 6 |
| 121 | ICAM4_1 | 0.0000001503 | 3.2501044823812903e-07 / 9.289397717877934e-06 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 3.1219185299958266e-05 / 2.7109747094287326e-07 | 6.095674277276536e-08 / 1.9332727891019487e-07 / 1.5381709053459223e-06 / 2.6680204178603233e-06 / 3.8772692803359075e-06 / 2.7997676176494448e-05 | 1.03498E-05 | 6 |
| 122 | HMCN1_1 | 0.0000002057 | 9.224071980226081e-07 / 6.979794879972793e-06 / 3.2501044823812903e-07 / 2.0071481202007584e-05 / 3.54688199707126e-05 / 2.7109747094287326e-07 | 2.325888657256971e-08 / 7.057956530849985e-08 / 4.408357829435433e-07 / 3.236174072045171e-07 / 2.3836720647269927e-06 / 1.2257808319403609e-05 | 1.06731E-05 | 6 |
| 123 | ZNF397_4 | 0.0000000000 | 1.1490697075516314e-07 / 5.267608369882088e-05 / 2.6997110563148354e-05 / 1.1548564870533097e-06 / 2.0333256661723552e-08 / 5.997442187105882e-06 | 1.209273134002773e-07 / 2.356993671060887e-07 / 1.889438601616299e-06 / 4.5197938838389625e-07 / 1.0616232919691243e-07 / 1.1196923674745125e-06 | 1.44935E-05 | 6 |
| 124 | DRAP1_1 | 0.0000000328 | 2.408755304649635e-05 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 2.0071481202007584e-05 / 5.1570472200670454e-05 | 1.8161954541326127e-08 / 2.3467711706414707e-08 / 7.39840605537318e-08 / 9.681901028699171e-08 / 6.251568155356543e-07 / 7.07965550831983e-07 | 1.77111E-05 | 6 |
| 125 | DTX3L_1 | 0.0000000920 | 2.408755304649635e-05 / 9.224071980226081e-07 / 9.289397717877934e-06 / 3.2501044823812903e-07 / 3.54688199707126e-05 / 5.1570472200670454e-05 | 3.2169896739895314e-07 / 6.548683737212715e-07 / 1.9632962963789034e-07 / 8.23683137309925e-07 / 1.3384906301502949e-06 / 3.688500356447034e-06 | 2.02773E-05 | 6 |
| 126 | NUDT11_5 | 0.0000000000 | 2.520077460838455e-06 / 0.00019847043212428944 / 9.212731853638905e-06 / 5.327685852957849e-05 / 7.074807022331135e-06 / 5.506319326881712e-06 | 6.030864046314226e-07 / 5.4148978375789446e-05 / 4.298503068923771e-06 / 4.6387467002391374e-07 / 3.113591613373381e-06 / 2.237597740187554e-06 | 4.60102E-05 | 6 |
| 127 | ADAM19_3 | 0.0000000000 | 0.00014925747204187325 / 2.926784989427661e-05 / 3.9436377050004215e-05 / 8.350382499334708e-05 / 9.099838750221392e-06 / 0.00012689846158790022 | 4.429367557026339e-06 / 3.859292848839367e-07 / 7.371158036631407e-06 / 3.558113101675235e-06 / 1.737907854441337e-05 / 1.0224109644328716e-05 | 7.29106E-05 | 6 |
| 128 | HS3ST4_2 | 0.0000000267 | 4.981322036893917e-06 / 2.606975599460185e-05 / 8.565659227788306e-05 / 0.0002754556536102276 / 7.209835341373319e-05 / 3.152964683173717e-05 | 1.1012098448593559e-06 / 1.1675757440124896e-05 / 1.5407255327564443e-05 / 1.049514284917264e-05 / 1.031858123131195e-05 / 0.0001438654836752122 | 8.26319E-05 | 6 |
| 129 | CRIPAK_4 | 0.0000000000 | 0.00015414987039053912 / 0.00011823367623626102 / 0.0009189200604961089 / 0.0007149452063580587 / 0.0006845676304155839 / 0.00041005648424125555 | 2.245806750816546e-06 / 4.7163754949833893e-07 / 2.309187383213676e-06 / 1.0481115140245655e-05 / 1.5648091897413959e-06 / 2.123855035553147e-06 | 0.000500145 | 6 |
| 130 | OLFM3_1 | 0.0000002915 | 1.1263759452799203e-06 / 9.971939174478468e-05 / 2.051237402337122e-05 / 0.0001395680222164631 / 0.0028963504457353837 / 7.924407878618111e-05 | 2.6837870218219574e-09 / 3.561518617190357e-08 / 1.882754136330223e-07 / 1.470434762035522e-07 / 3.069489887698277e-07 / 4.200340993458125e-06 | 0.00053942 | 6 |
| 131 | LMO2_4 | 0.0000000000 | 1.3505056742555753e-05 / 1.1618150079504721e-07 / 0.00013064212236741545 / 4.111357296377365e-06 / 0.0035192650416157674 / 4.781143220313644e-05 | 2.1639192493163854e-06 / 1.7833831305356847e-07 / 2.620411019163743e-06 / 2.1101434315006795e-06 / 2.7275081013397453e-05 / 1.3040674962690977e-06 | 0.000619242 | 6 |
| 132 | SALL2_1 | 0.0000003934 | 1.1263759452799203e-06 / 0.0038265104822853674 / 2.051237402337122e-05 / 0.0002944288613709527 / 0.0008581803853921776 / 0.00014547367344876742 | 1.6243939304465606e-09 / 9.280889011804578e-07 / 7.466764406748627e-07 / 6.300687009130246e-07 / 1.0493357935620423e-05 / 9.50907155614804e-07 | 0.000857705 | 6 |
| 133 | SLC35F3_1 | 0.0000002146 | 0.0008619727380490119 / 0.004410274724633273 / 8.807499017205126e-05 / 0.0007073001228128905 / 1.228676574562544e-05 / 0.002107325343692074 | 4.661997914978101e-07 / 8.34478701501445e-07 / 8.627333575428783e-07 / 1.0961759232568219e-05 / 1.5605455965805294e-06 / 4.962489165357357e-06 | 0.001364539 | 6 |
| 134 | RHOH_1 | 0.0000001993 | 1.887107728600381e-05 / 0.0001432193232982916 / 0.0002441254991542676 / 0.0020865035640383737 / 0.006227948945630897 / 0.00021988598115354305 | 8.908782275302052e-08 / 1.3002938709565544e-06 / 8.336014361253352e-07 / 1.0527458641807459e-06 / 1.1820153415714242e-05 / 2.4865375915662647e-06 | 0.001490092 | 6 |
| 135 | MED23_1 | 0.0000009756 | 0.0007073001228128905 / 0.0011323441860117745 / 0.004410274724633273 / 0.0010325370165401593 / 0.002107325343692074 / 0.0016226906289916678 | 1.0975653631511024e-07 / 1.045969028083387e-07 / 6.416985820926155e-07 / 1.5558825628623162e-06 / 8.122287757832368e-07 / 1.1607897314120871e-06 | 0.001835412 | 6 |
| 136 | ALS2CR8_2 | 0.0000000009 | 0.0006315082871911089 / 0.0005431426189626602 / 0.0021396275484352 / 0.026018702566094058 / 0.001000241728120363 / 0.0003308344387923977 | 1.2953287867816182e-06 / 3.495208827896601e-06 / 1.6445250431991489e-06 / 2.13746074336515e-05 / 1.4749418379777713e-06 / 1.7906341936525482e-06 | 0.005110676 | 6 |
| 137 | PDS5B_1 | 0.0000000930 | 0.009896861713608592 / 0.020827775351599746 / 0.0012471395414138215 / 0.0017014302658606788 / 0.0353590157796084 / 0.0012471395414138215 | 3.174956286948255e-05 / 2.3820952039675057e-05 / 7.64885082423866e-07 / 5.201073420332339e-07 / 3.138162419750589e-05 / 1.8874782131634276e-06 | 0.011713227 | 6 |
| 138 | POU4F1_1 | 0.0000343460 | 0.009505749235636515 / 0.01380503352362386 / 0.006032512595643146 / 0.016514991038692903 / 0.03991486389987273 / 0.023304012767638813 | 1.736820199971154e-08 / 1.0181132930253954e-06 / 0.00018045749659898887 / 7.716585431260322e-06 / 5.0799933930760124e-06 / 2.2950455177001124e-05 | 0.018179527 | 6 |
| 139 | LINGO1_4 | 0.0000000000 | 1.7973910992848286e-09 / 3.2068838263254377e-07 / 5.436354594228244e-06 / 9.44534744977059e-08 / 8.340191540542289e-07 | 4.250081788501893e-07 / 3.2784019242777824e-06 / 9.246191514674586e-06 / 6.77126904336827e-07 / 1.2203319241697544e-05 | 1.33746E-06 | 5 |
| 140 | EZH2_2 | 0.0000000004 | 2.2402150648537843e-08 / 1.471749614726362e-06 / 3.983245164121986e-08 / 8.584401402568793e-06 / 2.135362618124217e-07 | 7.330469554133431e-08 / 6.45181252176691e-06 / 2.8233957548442e-07 / 1.386977654368529e-06 / 3.4840585402585815e-07 | 2.06638E-06 | 5 |
| 141 | ZNF786_5 | 0.0000000000 | 0.00011773904137664178 / 1.3280032513820524e-05 / 9.576463103103271e-05 / 4.4014899917305675e-06 / 8.430577899747024e-06 | 2.140329000239017e-05 / 7.930355204992489e-07 / 4.145669385412816e-06 / 9.512787508368679e-07 / 2.434604498224823e-06 | 4.79232E-05 | 5 |
| 142 | SLCO5A1_1 | 0.0000008012 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 0.0003167991900078877 / 2.408755304649635e-05 / 9.289397717877934e-06 | 3.0174324318950897e-07 / 9.418668072896726e-07 / 1.6676348515768935e-05 / 3.957834622626353e-06 / 6.700293161768197e-06 | 7.02847E-05 | 5 |
| 143 | DKK2_1 | 0.0000006927 | 9.224071980226081e-07 / 2.7109747094287326e-07 / 3.2501044823812903e-07 / 0.0004073113752386311 / 9.289397717877934e-06 | 6.460209020485614e-08 / 3.59230415078595e-07 / 1.0312698979503442e-06 / 1.4199406561075603e-05 / 5.457198354391937e-06 | 8.36239E-05 | 5 |
| 144 | ATP11C_1 | 0.0000001503 | 2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 0.0004422271229621968 / 5.2109649171464235e-06 | 1.9332727891019487e-07 / 1.36409072963545e-08 / 3.1896874375468994e-07 / 4.81561728868056e-06 / 8.990145137526255e-07 | 9.11223E-05 | 5 |
| 145 | KMO_1 | 0.0000001461 | 1.887107728600381e-05 / 0.0001432193232982916 / 0.0005437871552770366 / 0.00021988598115354305 / 0.0002441254991542676 | 2.485807963409032e-07 / 1.1240339046572947e-06 / 3.782902556894412e-07 / 4.67845142282578e-06 / 3.603323688705048e-06 | 0.000233978 | 5 |
| 146 | SPOCD1_1 | 0.0000000083 | 3.2501044823812903e-07 / 2.0071481202007584e-05 / 9.224071980226081e-07 / 0.0019333915490623197 / 1.615375160694009e-05 | 7.818277659920641e-08 / 5.795083345677293e-07 / 4.4221671271015996e-06 / 9.908657729834685e-06 / 1.2284458405143113e-05 | 0.000394173 | 5 |
| 147 | LMO3_1 | 0.0000005163 | 2.0071481202007584e-05 / 9.224071980226081e-07 / 0.00029640089162746337 / 6.979794879972793e-06 / 0.005510243055764825 | 2.8303059659858582e-08 / 1.2770021336022465e-07 / 1.8886612700849868e-06 / 1.5048748666061165e-06 / 9.979708008853078e-07 | 0.001166924 | 5 |
| 148 | SUCLG2_1 | 0.0000006277 | 0.0012538224517635887 / 0.00030020193073310375 / 0.001142443802029975 / 0.0015995521116198169 / 0.0025493281320611745 | 6.010018117118236e-09 / 1.4873864874902438e-08 / 2.812059954690805e-06 / 4.5297727245223865e-07 / 1.0136268892104269e-06 | 0.00136907 | 5 |
| 149 | CDC42EP3_1 | 0.0000005053 | 0.00015668136762185704 / 0.0017937623479293012 / 0.00014067446309259184 / 0.0006379488254521119 / 0.0054623966213403945 | 4.0545605557306084e-07 / 2.0579987707958014e-06 / 6.648866334116203e-06 / 6.110689397168396e-05 / 5.05967411068452e-06 | 0.001638293 | 5 |
| 150 | VIM_2 | 0.0000150468 | 0.001194606450859983 / 0.00022458373669886374 / 0.00019944988446973612 / 0.006523673737606515 / 0.0004302878134597533 | 3.450494605886152e-11 / 2.904281074975244e-11 / 4.5432513762116924e-07 / 4.7610232918156417e-07 / 3.936782111680953e-06 | 0.00171452 | 5 |
| 151 | KIAA1456_5 | 0.0000000000 | 3.392135383479947e-09 / 1.6065108187886577e-09 / 9.157017996950809e-07 / 3.6928231492352363e-07 | 5.371804546576567e-07 / 8.674274096479547e-08 / 5.026970587223131e-06 / 3.9399829491464125e-06 | 3.22496E-07 | 4 |
| 152 | ATP1A1_1 | 0.0000003288 | 2.7109747094287326e-07 / 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 | 4.379090848715678e-06 / 3.77167172557141e-06 / 3.5551496515817035e-06 / 8.53191167142631e-06 | 2.12458E-06 | 4 |
| 153 | EFHD2_3 | 0.0000000000 | 2.621657181978166e-09 / 5.054801258373376e-07 / 9.68006271762989e-06 / 1.8365412363165977e-07 | 8.572257412643892e-07 / 1.794103459804273e-06 / 9.95075608052033e-06 / 1.2610525065949156e-05 | 2.59295E-06 | 4 |
| 154 | NPY1R_1 | 0.0000000555 | 3.2501044823812903e-07 / 9.289397717877934e-06 / 2.7109747094287326e-07 / 9.224071980226081e-07 | 3.314259306506593e-07 / 3.2811589034439775e-06 / 2.0319189662380453e-05 / 4.769447269863606e-06 | 2.70198E-06 | 4 |
| 155 | PTPN13_1 | 0.0000002820 | 2.7109747094287326e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 / 5.2109649171464235e-06 | 2.6783272230077516e-07 / 1.895295482848707e-08 / 1.8806480924583324e-07 / 9.335221622816497e-07 | 3.34607E-06 | 4 |
| 156 | SOX11_3 | 0.0000000001 | 1.2099644991608733e-05 / 2.0089868169610723e-07 / 1.0776466574906309e-07 / 4.755876859816789e-06 | 7.955105981028123e-06 / 1.0121247355306893e-06 / 3.4448329577362182e-06 / 1.4342875182087443e-05 | 4.29105E-06 | 4 |
| 157 | RAVER2_1 | 0.0000000192 | 3.2501044823812903e-07 / 9.289397717877934e-06 / 9.224071980226081e-07 / 1.3062838211579366e-05 | 3.105760909035132e-07 / 7.687495446941115e-07 / 1.1986592733451634e-06 / 9.900405822480467e-06 | 5.89991E-06 | 4 |
| 158 | CD44_3 | 0.0000000000 | 7.172707428277077e-07 / 4.481007438950932e-07 / 8.746535299915613e-07 / 2.5220058311922642e-05 | 1.7230525778249127e-07 / 2.754399275478179e-07 / 5.399255839823898e-06 / 5.404432984233412e-06 | 6.81502E-06 | 4 |
| 159 | WIPI1_1 | 0.0000000779 | 3.2501044823812903e-07 / 4.559947241482223e-05 / 9.224071980226081e-07 / 2.408755304649635e-05 | 2.847754855927293e-07 / 5.356440974504928e-05 / 3.583982029691469e-06 / 9.40961708804259e-06 | 1.77336E-05 | 4 |
| 160 | MEIG1_1 | 0.0000021159 | 2.768256422538597e-05 / 9.531965824595176e-05 / 3.738602753166595e-05 / 7.050646137918624e-07 | 3.8552589093989376e-07 / 5.403268031058945e-06 / 1.875181574291302e-06 / 3.691562617026471e-06 | 4.02733E-05 | 4 |
| 161 | ITGAV_1 | 0.0000043137 | 5.198191671140737e-06 / 2.078130544858706e-05 / 8.173042888768766e-05 / 6.124458953230731e-05 | 2.675335342140057e-08 / 5.91155167762294e-06 / 3.175137319143903e-07 / 1.4088412652065131e-05 | 4.22386E-05 | 4 |
| 162 | WASF1_2 | 0.0000000139 | 1.249810740543092e-06 / 4.033558519530211e-05 / 1.5172365718941338e-06 / 0.00016701924649532873 | 4.465170531049283e-08 / 7.347798043454918e-07 / 3.12571392342915e-07 / 2.1882250573351623e-06 | 5.25305E-05 | 4 |
| 163 | SEPT5_1 | 0.0000000779 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 0.0003167991900078877 / 2.0071481202007584e-05 | 4.6698972944525575e-06 / 2.50941550434497e-06 / 7.4466622077249586e-06 / 4.094296941956349e-06 | 8.45295E-05 | 4 |
| 164 | ZNF703_4 | 0.0000000000 | 2.212311553111884e-06 / 7.684875066256022e-06 / 1.6293260278199978e-05 / 0.0008381727818825804 | 3.314259306506593e-07 / 7.977471601458215e-07 / 1.8053474935255696e-05 / 2.523320003794371e-06 | 0.000216091 | 4 |
| 165 | RCAN1_1 | 0.0000004561 | 2.051237402337122e-05 / 0.0008581803853921776 / 1.1263759452799203e-06 / 0.00014547367344876742 | 1.151531177459646e-07 / 1.639867245393111e-05 / 1.1127380583214237e-07 / 3.9475777725155106e-07 | 0.000256323 | 4 |
| 166 | MEIS1_1 | 0.0000004303 | 0.0001249119186090808 / 0.001757554115983901 / 2.051237402337122e-05 / 0.000326206047495105 | 2.6783272230077516e-07 / 3.936737849973941e-06 / 1.6694305968259358e-06 / 7.365498385123174e-06 | 0.000557296 | 4 |
| 167 | DOCK9_2 | 0.0000000000 | 4.145085061135413e-05 / 3.702123384814164e-05 / 0.0003340879256796464 / 0.001986982649747413 | 2.7146173079304695e-06 / 2.6989667147770683e-07 / 5.081672826189643e-05 / 3.9279153945945585e-05 | 0.000599886 | 4 |
| 168 | MAP2K1_1 | 0.0000000599 | 0.0007934067413946306 / 0.001424661642376461 / 0.0001432193232982916 / 0.0001432193232982916 | 6.397852510979244e-07 / 1.229050427171932e-05 / 4.600454084913176e-07 / 1.216134119529828e-07 | 0.000626127 | 4 |
| 169 | BAZ2A_1 | 0.0000087909 | 0.0006400860846326889 / 0.00019507867134893112 / 0.0005646566395776797 / 0.0011256461353458978 | 3.4543484518327023e-07 / 2.666805309562172e-06 / 5.506146432831658e-07 / 2.9358775945182435e-06 | 0.000631367 | 4 |
| 170 | TMEM70_2 | 0.0000000042 | 0.000803532445292482 / 3.592934798967807e-05 / 2.0485173730412846e-05 / 0.002205124341612829 | 2.2344846667733606e-07 / 1.07351128025269e-06 / 3.1896874375468994e-07 / 3.0408081748624807e-06 | 0.000766268 | 4 |
| 171 | CSRP3_1 | 0.0000008027 | 0.0018449614599039168 / 0.00038686777181974065 / 0.00048368218865146016 / 0.001675382961010776 | 2.60376611739122e-06 / 2.102391157291273e-06 / 2.004512392075139e-06 / 1.2729780600591483e-06 | 0.001097724 | 4 |
| 172 | MSRB3_1 | 0.0000003307 | 2.1638869199653735e-05 / 0.0029815335281472605 / 0.0005737747064104953 / 0.007382285536659921 | 1.4806435472894142e-06 / 1.0110256424760308e-06 / 3.5361568488813283e-06 / 8.63235449098127e-05 | 0.002739808 | 4 |
| 173 | PTGER2_1 | 0.0000002152 | 0.00269524080408226 / 0.007101048391336863 / 0.00668150271306391 / 7.915379277260866e-05 | 3.584070271555361e-09 / 1.3436997812686243e-07 / 1.3606501871455058e-06 / 1.1858761514818132e-06 | 0.004139236 | 4 |
| 174 | ARHGAP44_2 | 0.0000005305 | 0.001389487072786441 / 3.911112061086556e-05 / 0.0072669444150837495 / 0.032560551569980084 | 1.5851926645157727e-06 / 5.333355940483967e-07 / 4.1196587397566423e-07 / 1.9907111943687763e-05 | 0.010314024 | 4 |
| 175 | TTC7A_2 | 0.0000431038 | 0.0034136112166290996 / 0.019663495986739683 / 0.015108389305698126 / 0.023304012767638813 | 1.9331908145550604e-07 / 2.9725508005745186e-07 / 6.456589638188038e-07 / 1.1620049901469098e-06 | 0.015372377 | 4 |
| 176 | SLC35F1_1 | 0.0000000393 | 9.224071980226081e-07 / 3.2501044823812903e-07 / 2.7109747094287326e-07 | 2.910892954811522e-06 / 2.427468480432927e-06 / 1.497883668566738e-05 | 5.06172E-07 | 3 |
| 177 | KRT25_4 | 0.0000000910 | 1.8022657475902624e-06 / 3.876432302949376e-08 / 9.243212121314035e-07 | 8.698985549478663e-06 / 1.3122203018407308e-05 / 2.3955519604051558e-05 | 9.21784E-07 | 3 |
| 178 | PAX7_1 | 0.0000004451 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 5.2109649171464235e-06 | 2.237597740187554e-06 / 4.6661224912755335e-06 / 6.814494589515358e-05 | 2.15279E-06 | 3 |
| 179 | ENC1_1 | 0.0000002820 | 3.2501044823812903e-07 / 9.224071980226081e-07 / 6.979794879972793e-06 | 1.9120440072426562e-07 / 4.6661224912755335e-06 / 2.0866430814653658e-06 | 2.7424E-06 | 3 |
| 180 | ERO1L_3 | 0.0000000002 | 4.539445950022412e-06 / 2.5790650047618876e-07 / 3.931265767356836e-06 | 8.753743400501336e-05 / 2.307172538255043e-06 / 0.0001811706174672882 | 2.90954E-06 | 3 |
| 181 | KANSL2_2 | 0.0000000036 | 5.454092964102538e-06 / 2.0483330180932313e-06 / 1.3610927050562742e-06 | 1.3993846023737915e-07 / 4.67736331535542e-05 / 3.809175259493249e-06 | 2.95451E-06 | 3 |
| 182 | RPN1_3 | 0.0000000004 | 8.225833660011401e-07 / 8.696575941061198e-06 / 2.1691780926743226e-07 | 2.5845817998249264e-07 / 2.15788202970697e-06 / 7.928931114532352e-06 | 3.24536E-06 | 3 |
| 183 | PTGER3_2 | 0.0000000653 | 6.627915836434039e-07 / 2.668064610627935e-06 / 6.6526771052306895e-06 | 4.987581945086968e-07 / 6.416985820926155e-07 / 1.042398266072424e-06 | 3.32784E-06 | 3 |
| 184 | CACHD1_2 | 0.0000000001 | 6.841823795764238e-06 / 1.1611327091078624e-06 / 3.757056495538064e-06 | 6.036905353459894e-07 / 1.7240231306506295e-06 / 2.495170691986825e-05 | 3.92E-06 | 3 |
| 185 | VPS37D_2 | 0.0000000001 | 8.999654334938381e-06 / 3.0621601602130305e-06 / 2.72061163246224e-07 | 5.620700861394285e-07 / 1.1802005266016428e-06 / 1.1362044976111473e-06 | 4.11129E-06 | 3 |
| 186 | ZDHHC17_1 | 0.0000000110 | 1.3062838211579366e-05 / 9.289397717877934e-06 / 3.2501044823812903e-07 | 1.9472709844203468e-07 / 8.64813860440053e-09 / 4.08973006429415e-08 | 7.55908E-06 | 3 |
| 187 | TMEM9B_2 | 0.0000000138 | 1.0001419899907697e-05 / 2.088214452889034e-05 / 3.1085970554200676e-07 | 7.663345318857788e-08 / 9.904773066152364e-07 / 1.645825440209025e-06 | 1.03981E-05 | 3 |
| 188 | HOXD10_1 | 0.0000000921 | 2.7109747094287326e-07 / 3.1219185299958266e-05 / 9.224071980226081e-07 | 2.565463018954012e-06 / 1.941433683772925e-06 / 4.178051372181341e-06 | 1.08042E-05 | 3 |
| 189 | ITFG2_1 | 0.0000005163 | 4.559947241482223e-05 / 2.0071481202007584e-05 / 5.2109649171464235e-06 | 3.439076468267492e-06 / 5.9260015900657735e-06 / 5.4469810926531135e-05 | 2.36273E-05 | 3 |
| 190 | EGFL7_1 | 0.0000000299 | 1.1263759452799203e-06 / 4.369070707050029e-05 / 0.00018252021476464813 | 1.8700341255096223e-09 / 5.293074654152259e-06 / 1.2852959762944565e-05 | 7.57791E-05 | 3 |
| 191 | PPP2R2A_5 | 0.0000000000 | 2.3018920608566846e-05 / 2.515879541149387e-06 / 0.00026563530537353084 | 2.892554421707878e-06 / 2.79139624836141e-06 / 0.0002549462415116326 | 9.70567E-05 | 3 |
| 192 | BRF2_2 | 0.0000000001 | 9.751314166241359e-06 / 0.0003129016625892748 / 0.00016417889880625215 | 3.759229641754634e-08 / 2.1837529883578724e-05 / 1.5455954512499827e-06 | 0.000162277 | 3 |
| 193 | ATP1B2_1 | 0.0000007792 | 8.350565572888588e-05 / 0.0003022930393277112 / 0.00012034822430170891 | 4.9185008634943495e-06 / 1.749159859965176e-05 / 1.758385056892761e-05 | 0.000168716 | 3 |
| 194 | PTGES3_2 | 0.0000000002 | 0.00028889915694293186 / 0.0004343373075467472 / 2.3874708929429098e-06 | 6.3806928808699615e-06 / 3.6976674058849736e-07 / 2.590931905512812e-06 | 0.000241875 | 3 |
| 195 | NR0B1_2 | 0.0000000017 | 0.00095500393558891 / 4.835640776889601e-06 / 1.3401582342156554e-08 | 0.00012317884029827643 / 9.41313565329906e-05 / 1.946170412794958e-05 | 0.000319951 | 3 |
| 196 | GALNT10_2 | 0.0000073319 | 0.001194606450859983 / 0.00022458373669886374 / 0.00019944988446973612 | 4.2967502063254294e-08 / 2.7580106394921852e-08 / 1.6050811528160658e-07 | 0.000539547 | 3 |
| 197 | TMEM229A_1 | 0.0000019763 | 1.1263759452799203e-06 / 0.0017875715263402634 / 2.051237402337122e-05 | 4.470056894883235e-08 / 3.212400793996756e-05 / 3.0330851096686316e-06 | 0.00060307 | 3 |
| 198 | NCEH1_1 | 0.0000021880 | 0.0025176594807100345 / 2.9249667673039124e-05 / 0.00049387566368266 | 2.9852999237846436e-07 / 3.6664065520662378e-06 / 1.4296784245243089e-06 | 0.001013595 | 3 |
| 199 | C1orf27_1 | 0.0000005347 | 2.4400796134349794e-05 / 0.00048683461556788134 / 0.004468346085026116 | 3.3728825978612466e-08 / 1.7773181504273556e-05 / 1.1552987857913018e-05 | 0.00165986 | 3 |
| 200 | TMEM14C_1 | 0.0000014171 | 0.00013494197652300576 / 0.008044269920970437 / 0.00043124882395994033 | 1.4472691259712559e-07 / 6.268977803019969e-07 / 2.4350896869975287e-07 | 0.002870154 | 3 |
| 201 | DKK3_1 | 0.0000003462 | 0.0013248126277991738 / 0.0010602701525608943 / 0.008185982685681903 | 1.5846200021034092e-07 / 9.094647997910571e-07 / 1.069596462403796e-05 | 0.003523688 | 3 |
| 202 | LRRC4C_1 | 0.0000000007 | 0.001612584660708291 / 0.008357898545557461 / 0.004641723683002966 | 5.839066787020226e-06 / 8.030484942525321e-05 / 2.874321825060119e-06 | 0.004870736 | 3 |
| 203 | HOXD9_1 | 0.0000001816 | 0.003521766194763358 / 0.009358203838825317 / 0.006565901152596447 | 8.908782275302052e-08 / 1.4262192253107675e-06 / 1.1653976873204907e-05 | 0.006481957 | 3 |
| 204 | SLC5A6_2 | 0.0000083594 | 0.00329856915210616 / 0.016629670900162985 / 0.003718378687262143 | 3.9237422990064166e-08 / 2.1675313933802943e-06 / 3.4461744463603383e-07 | 0.007882206 | 3 |
| 205 | LYPD1_1 | 0.0039884477 | 0.00561851618326168 / 0.010298037138015295 / 0.011465748499709204 | 0.00012364715000227235 / 7.610927192464296e-06 / 3.436634759679429e-05 | 0.009127434 | 3 |
| 206 | CIB1_1 | 0.0000012582 | 2.4400796134349794e-05 / 0.025949952318682364 / 0.005327800743076973 | 6.521419935683383e-08 / 0.0001508899394071643 / 2.7037258898085093e-06 | 0.010434051 | 3 |
| 207 | PDSS1_2 | 0.0000001438 | 2.087686423298029e-05 / 0.032547979119801014 / 0.0009731125399429332 | 9.181067152023525e-08 / 1.866363701474153e-07 / 7.882821468850854e-06 | 0.011180656 | 3 |
| 208 | SHC2_1 | 0.0000043527 | 0.008666672397448167 / 0.01221055371440681 / 0.023108053632132773 | 3.5046868808471237e-08 / 1.4152639674778885e-07 / 1.1044438525648634e-06 | 0.01466176 | 3 |
| 209 | ATP6V0B_1 | 0.0000652113 | 0.0017008783545293586 / 0.03338582426278086 / 0.022359654779542756 | 1.8156513888722432e-05 / 0.0006738450240411453 / 0.00015710780312305387 | 0.019148786 | 3 |
| 210 | SEPSECS_1 | 0.0000880523 | 0.03187722870624648 / 0.03280798665424235 / 0.039867021959100635 | 2.337882197149697e-08 / 1.6555950610598878e-06 / 2.8381722284939996e-06 | 0.034850746 | 3 |
| 211 | BHLHE22_2 | 0.0000000002 | 1.3401582342156554e-08 / 4.659755401849588e-08 | 1.3361783713514048e-06 / 9.916119753409963e-07 | 2.99996E-08 | 2 |
| 212 | FOXC1_1 | 0.0000001081 | 3.2501044823812903e-07 / 9.224071980226081e-07 | 2.464261525645891e-06 / 8.614020001816719e-06 | 6.23709E-07 | 2 |
| 213 | DMRTA1_1 | 0.0000001005 | 1.0687433356337492e-05 / 7.348784993241683e-08 | 1.8860719855838867e-06 / 7.505602457021459e-06 | 5.38046E-06 | 2 |
| 214 | CRYBG3_2 | 0.0000000000 | 7.842763361037193e-06 / 6.517914638754384e-06 | 1.266977339256832e-07 / 1.1569843022665961e-05 | 7.18034E-06 | 2 |
| 215 | ANKRD28_1 | 0.0000001762 | 3.2501044823812903e-07 / 2.0071481202007584e-05 | 2.0833362771380855e-07 / 1.1004838243302006e-06 | 1.01982E-05 | 2 |
| 216 | ZNF467_3 | 0.0000000000 | 1.6294904067329883e-05 / 1.3870388730546243e-05 | 7.288715501245973e-07 / 2.038126089530678e-07 | 1.50826E-05 | 2 |
| 217 | MCU_1 | 0.0000000041 | 4.559947241482223e-05 / 2.7109747094287326e-07 | 0.00014805201662727028 / 1.3235442660276658e-05 | 2.29353E-05 | 2 |
| 218 | ALG6_1 | 0.0000000034 | 4.559947241482223e-05 / 9.289397717877934e-06 | 7.757632613398362e-05 / 1.8142742683524817e-06 | 2.74444E-05 | 2 |
| 219 | DST_1 | 0.0000000354 | 1.1263759452799203e-06 / 0.00018252021476464813 | 2.5055687616812065e-08 / 7.501693754343125e-06 | 9.18233E-05 | 2 |
| 220 | CNOT6_1 | 0.0000000101 | 1.1263759452799203e-06 / 0.0002944288613709527 | 1.1075622702926509e-08 / 1.129572691211572e-06 | 0.000147778 | 2 |
| 221 | SLC25A46_1 | 0.0000002913 | 0.00036105139567184824 / 0.00014547367344876742 | 2.5994147109530116e-05 / 4.968741535651153e-06 | 0.000253263 | 2 |
| 222 | STRBP_3 | 0.0000000000 | 1.5669300524965997e-07 / 0.0005064725174938412 | 1.481967113051988e-07 / 1.3155160149040273e-05 | 0.000253315 | 2 |
| 223 | SLFN11_1 | 0.0000000685 | 2.4400796134349794e-05 / 0.00048683461556788134 | 1.0022702721591722e-05 / 9.972925901562962e-06 | 0.000255618 | 2 |
| 224 | IL1R1_1 | 0.0000016239 | 0.000617308483698201 / 6.569591094283755e-05 | 4.5432680388905903e-07 / 9.107588752182431e-08 | 0.000341502 | 2 |
| 225 | PDE9A_2 | 0.0000000400 | 0.00041731220668757806 / 0.0005855390414154741 | 1.221895236718122e-05 / 4.308375284196633e-07 | 0.000501426 | 2 |
| 226 | TXNDC11_1 | 0.0000008009 | 0.00037816990481376106 / 0.001675382961010776 | 3.35563055514752e-05 / 1.6158804956085833e-05 | 0.001026776 | 2 |
| 227 | NRP1_2 | 0.0000038002 | 0.0004994794183737504 / 0.002324394606725177 | 5.465744973286784e-06 / 7.656204640097829e-05 | 0.001411937 | 2 |
| 228 | QSER1_1 | 0.0000182809 | 0.0013570458512569155 / 0.002178697316418811 | 9.58284147411479e-06 / 8.84455021841255e-06 | 0.001767872 | 2 |
| 229 | TNIP1_1 | 0.0000036678 | 5.198191671140737e-06 / 0.004144214246475889 | 6.508715673074529e-09 / 0.00019241774459470402 | 0.002074706 | 2 |
| 230 | LIMS1_1 | 0.0000029556 | 0.0018263671837831345 / 0.0029439691339069544 | 1.6606027203704394e-06 / 2.8416546588022426e-06 | 0.002385168 | 2 |
| 231 | PNISR_1 | 0.0000015994 | 0.0010325370165401593 / 0.00423890420622936 | 1.0714836567004093e-06 / 4.211924899648025e-05 | 0.002635721 | 2 |
| 232 | MOAP1_1 | 0.0001095279 | 0.0013957283134908426 / 0.004002216537936575 | 1.439059920097413e-05 / 4.3262437480883325e-07 | 0.002698972 | 2 |
| 233 | KAT2B_3 | 0.0000000754 | 0.00036235601618888415 / 0.0056682839670987315 | 7.275549292242543e-06 / 6.222503271842437e-05 | 0.00301532 | 2 |
| 234 | NBAS_2 | 0.0001936498 | 0.002248148734104571 / 0.003937219671693211 | 5.238094547402913e-05 / 2.261642163972036e-05 | 0.003092684 | 2 |
| 235 | RPAP3_1 | 0.0000000959 | 0.006578021053153416 / 0.0003022930393277112 | 0.00010709405231539574 / 5.7996012896130105e-05 | 0.003440157 | 2 |
| 236 | PCDH8_1 | 0.0000003649 | 0.001612584660708291 / 0.0053998526759721725 | 6.979705922681422e-07 / 2.352485760414308e-06 | 0.003506219 | 2 |
| 237 | NRTN_1 | 0.0000000085 | 0.006576322331343084 / 0.000682440200485821 | 1.3872766655850854e-09 / 1.1570279948530293e-08 | 0.003629381 | 2 |
| 238 | NFE2L3_3 | 0.0000025415 | 0.006071092121717285 / 0.001441190253067779 | 0.0007954168620537718 / 2.313845386160375e-05 | 0.003756141 | 2 |
| 239 | AXL_2 | 0.0000082526 | 0.004702764394990607 / 0.0030062439789624545 | 1.694397819105341e-07 / 2.938209735715061e-06 | 0.003854504 | 2 |
| 240 | FAM84B_1 | 0.0000011219 | 0.00253490211532945 / 0.006638130601347837 | 9.817330455454356e-07 / 1.8299892086956357e-05 | 0.004586516 | 2 |
| 241 | SERPING1_2 | 0.0000000003 | 0.00029302171972017536 / 0.00899955161467775 | 5.171117305573901e-07 / 3.4719444187468846e-06 | 0.004646287 | 2 |
| 242 | MAN2A2_1 | 0.0000016596 | 0.008666656930380014 / 0.0017164152096634118 | 3.010976905505238e-07 / 1.2681089550233342e-06 | 0.005191536 | 2 |
| 243 | PPP1R1B_2 | 0.0000081910 | 0.0007369895164838126 / 0.015544944078315552 | 4.952255809431967e-06 / 0.0008507571424411441 | 0.008140967 | 2 |
| 244 | LIM2_1 | 0.0000574583 | 0.015037462614525989 / 0.0066321488107590094 | 1.3552898512014677e-07 / 1.5995954452124522e-06 | 0.010834806 | 2 |
| 245 | ENC1_1 | 0.0000008380 | 0.019200633106000394 / 0.0072430591690685955 | 9.369739248583604e-07 / 9.796657658766679e-08 | 0.013221846 | 2 |
| 246 | TXNDC15_1 | 0.0002035799 | 0.01560397243862297 / 0.026007387241751754 | 1.3487999148831977e-05 / 2.383861518054849e-06 | 0.02080568 | 2 |
| 247 | CTGF_1 | 0.0006621219 | 0.04284073842146925 / 0.004328209862304807 | 1.2802249170334234e-06 / 4.161322882701981e-06 | 0.023584474 | 2 |
| 248 | EGFLAM_2 | 0.0000009904 | 9.101668425963222e-05 / 0.04959722009227676 | 2.2688565832705132e-07 / 4.996639973079422e-06 | 0.024844118 | 2 |
| 249 | ARHGAP10_2 | 0.0000000002 | 1.0829140297466289e-09 | 3.358932763107935e-10 | 1.08291E-09 | 1 |
| 250 | EBF3_1 | 0.0000002820 | 2.7109747094287326e-07 | 1.8343370720153953e-05 | 2.71097E-07 | 1 |
| 251 | PLAGL2_1 | 0.0000000508 | 3.2501044823812903e-07 | 1.8455903922148852e-07 | 3.2501E-07 | 1 |
| 252 | XKR4_3 | 0.0000000000 | 3.984768315573071e-07 | 3.1239365009333255e-05 | 3.98477E-07 | 1 |
| 253 | HR_1 | 0.0000000121 | 9.224071980226081e-07 | 1.9179741330821166e-06 | 9.22407E-07 | 1 |
| 254 | GLB1L2_1 | 0.0000000160 | 1.1263759452799203e-06 | 7.033045636092652e-08 | 1.12638E-06 | 1 |
| 255 | GOLIM4_1 | 0.0000004900 | 1.1263759452799203e-06 | 6.007938707379104e-06 | 1.12638E-06 | 1 |
| 256 | TMEM127_1 | 0.0000000593 | 1.1263759452799203e-06 | 4.773025688625418e-08 | 1.12638E-06 | 1 |
| 257 | USP21_1 | 0.0000003387 | 1.1263759452799203e-06 | 9.225028218311642e-07 | 1.12638E-06 | 1 |
| 258 | FAIM_5 | 0.0000000000 | 1.1673685534992903e-06 | 9.826697889420593e-07 | 1.16737E-06 | 1 |
| 259 | COX19_2 | 0.0000000297 | 2.674810306988624e-06 | 6.962982384295879e-06 | 2.67481E-06 | 1 |
| 260 | LRP10_3 | 0.0000000000 | 4.146152323500948e-06 | 2.8381722284939996e-06 | 4.14615E-06 | 1 |
| 261 | ASPH_1 | 0.0000031107 | 5.198191671140737e-06 | 1.24607424448712e-09 | 5.19819E-06 | 1 |
| 262 | CASP4_1 | 0.0000231527 | 5.198191671140737e-06 | 8.920036916236078e-07 | 5.19819E-06 | 1 |
| 263 | PPFIBP1_1 | 0.0000009218 | 5.198191671140737e-06 | 2.822471900981502e-07 | 5.19819E-06 | 1 |
| 264 | PRRX2_1 | 0.0000102422 | 5.198191671140737e-06 | 1.997454040091158e-06 | 5.19819E-06 | 1 |
| 265 | TADA1_1 | 0.0000011043 | 5.198191671140737e-06 | 4.130298014547339e-06 | 5.19819E-06 | 1 |
| 266 | FBXO15_2 | 0.0000000001 | 7.752739683840974e-06 | 1.0459642383728147e-08 | 7.75274E-06 | 1 |
| 267 | RPRD1A_3 | 0.0000000001 | 1.0121621258597313e-05 | 5.117366799673119e-08 | 1.01216E-05 | 1 |
| 268 | HS3ST3B1_2 | 0.0000000001 | 1.589621421980893e-05 | 5.712322089852472e-05 | 1.58962E-05 | 1 |
| 269 | RBM39_1 | 0.0000000427 | 1.615375160694009e-05 | 1.0486585374452342e-06 | 1.61538E-05 | 1 |
| 270 | MRPS34_1 | 0.0000059445 | 2.078130544858706e-05 | 3.007629978522511e-07 | 2.07813E-05 | 1 |
| 271 | PPARD_1 | 0.0000000391 | 2.4400796134349794e-05 | 1.781378071484659e-07 | 2.44008E-05 | 1 |
| 272 | TRIM29_2 | 0.0000000342 | 2.5328503789616034e-05 | 3.171256366090173e-06 | 2.53285E-05 | 1 |
| 273 | SLITRK3_2 | 0.0000000001 | 2.606975599460185e-05 | 1.5642166542934073e-05 | 2.60698E-05 | 1 |
| 274 | AOX1_1 | 0.0000000161 | 2.9249667673039124e-05 | 1.5889876142270276e-06 | 2.92497E-05 | 1 |
| 275 | WDR41_1 | 0.0000008795 | 3.490933492066787e-05 | 0.00031815123884038185 | 3.49093E-05 | 1 |
| 276 | WDR60_1 | 0.0000000100 | 3.54688199707126e-05 | 5.069649573469536e-05 | 3.54688E-05 | 1 |
| 277 | ELOVL1_1 | 0.0000000046 | 3.613318380627543e-05 | 2.329132806551381e-05 | 3.61332E-05 | 1 |
| 278 | ISYNA1_1 | 0.0000000671 | 4.335544688590604e-05 | 1.6739811178590666e-07 | 4.33554E-05 | 1 |
| 279 | BTBD17_1 | 0.0000001085 | 4.559947241482223e-05 | 5.155148635414614e-07 | 4.55995E-05 | 1 |
| 280 | E2F6_1 | 0.0000000779 | 4.559947241482223e-05 | 1.7462091622562324e-05 | 4.55995E-05 | 1 |
| 281 | REEP5_1 | 0.0000012251 | 4.559947241482223e-05 | 4.0559240566408105e-05 | 4.55995E-05 | 1 |
| 282 | HIF3A_2 | 0.0000001724 | 5.1802263378395004e-05 | 7.343981030754773e-06 | 5.18023E-05 | 1 |
| 283 | PLIN3_1 | 0.0000007202 | 7.498301012054149e-05 | 8.715915351978061e-08 | 7.4983E-05 | 1 |
| 284 | SLC25A43_1 | 0.0000000584 | 7.498301012054149e-05 | 1.042304728724042e-06 | 7.4983E-05 | 1 |
| 285 | NINL_2 | 0.0000000000 | 8.157777488089495e-05 | 1.9047854067387114e-06 | 8.15778E-05 | 1 |
| 286 | ZNF232_2 | 0.0000000005 | 9.615096996117447e-05 | 2.7228077881606553e-05 | 9.6151E-05 | 1 |
| 287 | SIRT4_5 | 0.0000000006 | 9.759198409764184e-05 | 0.00022059348443664346 | 9.7592E-05 | 1 |
| 288 | TP53BP2_1 | 0.0000015006 | 0.00011602560329098725 | 1.0705081193459222e-06 | 0.000116026 | 1 |
| 289 | DLGAP1_1 | 0.0000000768 | 0.0001432193232982916 | 3.5620325640614317e-07 | 0.000143219 | 1 |
| 290 | ELL2_1 | 0.0000001831 | 0.00014547367344876742 | 1.8060650315234512e-06 | 0.000145474 | 1 |
| 291 | L3MBTL1_1 | 0.0000000672 | 0.00015165886425239433 | 2.7256307870565235e-06 | 0.000151659 | 1 |
| 292 | VCL_1 | 0.0000000164 | 0.00015165886425239433 | 3.3683533578357084e-06 | 0.000151659 | 1 |
| 293 | FOXN4_1 | 0.0000000718 | 0.00018648294090879803 | 6.71170895523933e-08 | 0.000186483 | 1 |
| 294 | DGKD_2 | 0.0000000001 | 0.00021891772305978252 | 3.0596605696933097e-07 | 0.000218918 | 1 |
| 295 | UHMK1_2 | 0.0000022832 | 0.0002538027145357861 | 1.287838376941801e-06 | 0.000253803 | 1 |
| 296 | ATG10_1 | 0.0000013709 | 0.00045105792374135455 | 1.9817995812370057e-05 | 0.000451058 | 1 |
| 297 | RTN4_1 | 0.0000004000 | 0.0005279514394131604 | 2.4302265052169763e-06 | 0.000527951 | 1 |
| 298 | ZBTB34_2 | 0.0000000006 | 0.000905796995991497 | 2.480782410785219e-06 | 0.000905797 | 1 |
| 299 | TRAPPC1_1 | 0.0000002410 | 0.0009321635980700065 | 5.038494138176741e-08 | 0.000932164 | 1 |
| 300 | MAN1A1_1 | 0.0000012120 | 0.0010091155669931342 | 9.89628655829039e-07 | 0.001009116 | 1 |
| 301 | GPR155_1 | 0.0000001571 | 0.0010353911778693099 | 2.456527177029259e-08 | 0.001035391 | 1 |
| 302 | NUP205_1 | 0.0000011129 | 0.0012133361599562802 | 4.618395361515403e-05 | 0.001213336 | 1 |
| 303 | DFNA5_1 | 0.0000000842 | 0.0013248126277991738 | 1.0306269703522314e-06 | 0.001324813 | 1 |
| 304 | ESYT2_1 | 0.0000000362 | 0.0014584828902455792 | 1.480537378886556e-06 | 0.001458483 | 1 |
| 305 | ARRDC5_1 | 0.0000004478 | 0.0016631235717637551 | 5.470825563951457e-06 | 0.001663124 | 1 |
| 306 | WWOX_1 | 0.0000000652 | 0.001710012299865077 | 3.466057717888151e-05 | 0.001710012 | 1 |
| 307 | TTC12_1 | 0.0000000828 | 0.001757554115983901 | 1.1207466412214644e-06 | 0.001757554 | 1 |
| 308 | PHLDA1_1 | 0.0000002242 | 0.0025176594807100345 | 2.681228774385004e-07 | 0.002517659 | 1 |
| 309 | USP44_2 | 0.0000000006 | 0.002828735395322951 | 7.615307891070635e-07 | 0.002828735 | 1 |
| 310 | PLTP_1 | 0.0000001423 | 0.0037115156714849027 | 6.256739082396771e-06 | 0.003711516 | 1 |
| 311 | FOXK2_2 | 0.0017280500 | 0.004268133535531114 | 1.124004668909467e-06 | 0.004268134 | 1 |
| 312 | ERRFI1_1 | 0.0000343124 | 0.004549100059734061 | 2.615853467480574e-06 | 0.0045491 | 1 |
| 313 | NCAPG2_2 | 0.0000096301 | 0.004679455399141524 | 3.410090272140929e-05 | 0.004679455 | 1 |
| 314 | GNG12_2 | 0.0000008966 | 0.004702764394990607 | 2.448152787066068e-07 | 0.004702764 | 1 |
| 315 | GTF2IRD1_2 | 0.0000000000 | 0.005180332874805364 | 1.0191189286267774e-05 | 0.005180333 | 1 |
| 316 | CDH13_1 | 0.0000528396 | 0.008698504315979544 | 5.505206380486848e-07 | 0.008698504 | 1 |
| 317 | USPL1_1 | 0.0000887089 | 0.008919618004927028 | 2.867060371186775e-05 | 0.008919618 | 1 |
| 318 | C8orf33_2 | 0.0000000686 | 0.012040847937930112 | 6.965053271201718e-06 | 0.012040848 | 1 |
| 319 | LARP4_1 | 0.0000539238 | 0.012598829000918008 | 1.5446384568414948e-07 | 0.012598829 | 1 |
| 320 | WISP2_3 | 0.0007560493 | 0.015549504727258205 | 4.1338081640385414e-05 | 0.015549505 | 1 |
| 321 | ACTR3B_1 | 0.0000005421 | 0.01578579910468178 | 2.8755424998338056e-06 | 0.015785799 | 1 |
| 322 | CACNA1H_1 | 0.0000005564 | 0.016412811603890378 | 2.7000252287495107e-06 | 0.016412812 | 1 |
| 323 | KIT_5 | 0.0000464952 | 0.018517123226998455 | 6.704030752101419e-08 | 0.018517123 | 1 |
| 324 | PFKFB4_1 | 0.0000652997 | 0.020508581406833964 | 3.9540280994682333e-05 | 0.020508581 | 1 |
| 325 | PRKCA_1 | 0.0000002757 | 0.022453642395359744 | 8.550515929117645e-06 | 0.022453642 | 1 |
| 326 | PPIB_1 | 0.0005395298 | 0.022633220383071653 | 1.1620529438552381e-07 | 0.02263322 | 1 |
| 327 | GUK1_1 | 0.0002165806 | 0.025889538503308045 | 0.00027733726642677973 | 0.025889539 | 1 |
| 328 | TOMM20_1 | 0.0000295101 | 0.026424697119045135 | 5.7696335620157635e-06 | 0.026424697 | 1 |
| 329 | MCFD2_1 | 0.0000296801 | 0.02889039127169977 | 5.21788791253075e-06 | 0.028890391 | 1 |
| 330 | ARL2BP_1 | 0.0009748737 | 0.03656942798482464 | 2.769366837708274e-07 | 0.036569428 | 1 |
| 331 | DSTN_2 | 0.0000209668 | 0.040590852862758056 | 0.0002808473162478281 | 0.040590853 | 1 |
다음으로, 본 발명에서 기능하플로타입을 이용한 GBLscan을 통하여 산출된, 각 약물타입 별로 약물에 대한 반응성에 영향을 미치는 바이오마커에 대하여 설명한다.
구체적으로, 약물타입(Drug Class)의 구분 별로, ABL의 바이오 마커 108개(표 15참조), CHROMATIN의 바이오 마커 132개(표 16참조), EGFR의 바이오 마커 832개(표 17참조), ERK_MAPK의 바이오 마커 42개(표 18참조), IGFR의 바이오 마커 153개(표 19참조), MITOSIS의 바이오 마커 88개(표 20참조)이다.
아래 [표 15] 내지 [표 20]에는 약물타입 별로 본 발명에 의해 발굴된 바이오 마커들이 포함되어 표시되어 있다. 여기서 바이오 마커의 형태 및 표현 방식은 전술한 암종류별로 구분된 바이오 마커와 동일하다.
| 구분 | DrugClass | Drugs | Pathway & signaling(Target gene & function) |
| 1 | ABL | Imatinib, GNF-2, Dasatinib, Saracatinib, WH-4-023, Bosutinib, Ponatinib, HG-5-113-01, Nilotinib | ABL, SRC, KIT, PDGFR, ABL1,TEC, LOK, LTK, TRCB, |
| 2 | CHROMATIN | Phenformin, AICA_Ribonucleotide, Daporinad | HDAC, RAR, HDAC inhibitor Class I, IIa, IIb, IV; HDAC6, EGFR, G9a(EHMT2), GLP(EHMT1), Q8TEK3 (DOT1L), BRD2, BRD3, BRD4 |
| 3 | EGFR | Gefitinib, Erlotinib, Cetuiximab, Lapatinib, Afatinib, HG-5-88-01, CP724714, Pelitinib | ERBB2, EGFR, ADCK4 |
| 4 | ERK_MAPK | Dabrafenib, VX-11e, AZ628, Selumetinib, CI-1040, PD0325901, Selumetinib, Refametinib, Trametinib, TL-2-105, HG6-64-1, PLX-4720, SB590885, SL0101, CMK, FMK, FR=180204 | MAP2K1 (MEK1), MAP2K2 (MEK2), BRAF, ERK, RSK, AURKB, PIM3, CRAF, BRAFV600E, TAK, MAP4K5 |
| 5 | IGFR | CSK1904529A, BMS-536924, BMS-754807, Linsitinib | IGF1R |
| 6 | MITOSIS | Dacinostat, JQ1, SGC0946, VNLG/124, UNC0638, Belinostat, CUDC-101, Vorinostat, CAY10603, AR-42, I-BET-762, Tubastatin A, PFI-1, Entinostat, JQ12 | AURKB, MPS1, KIF11, AURKA, PLK3, AURKC, FLT3, ABL1, JAK2, PLK3 |
[표 15]에는 ABL 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 15]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 37에는 [표 15]에 기재된 바이오마커들 중 주요 바이오마커들의 ABL 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Variants(마커) | Var_Drug(pval) | Var_Exp(Pval) |
| 1 | MEI1_1 | 22_41743050_G_A | 4.85E-06 | 0.048265101 |
| 2 | MYO1E_1 | 15_59223315_G_A | 9.45E-06 | 0.007356789 |
| 3 | HSPG2_1 | 1_21855190_T_G | 3.11E-05 | 0.047030976 |
| 4 | DUS1L_1 | 17_82060026_C_T | 3.91E-05 | 0.03583129 |
| 5 | ANXA2_1 | 15_60382524_A_G | 5.75E-05 | 0.01380595 |
| 6 | CDA_1 | 1_20613970_T_C | 0.000123749 | 0.01233326 |
| 7 | R3HDM1_1 | 2_135621624_GT_G | 0.000150326 | 0.007933574 |
| 8 | HMGB1_1 | 13_30465849_T_C | 0.000160907 | 1.54E-07 |
| 9 | TRIM35_1 | 8_27311444_G_A | 0.000300142 | 0.010188344 |
| 10 | NMT2_1 | 10_15119275_A_C | 0.000338877 | 0.015194231 |
| 11 | WWC1_1 | 5_168453939_T_G | 0.000400908 | 0.007809824 |
| 12 | EPB41_1 | 1_28987461_G_A | 0.000407874 | 0.032052572 |
| 13 | TGS1_1 | 8_55790504_CT_C | 0.000507403 | 0.000527822 |
| 14 | CLIP4_1 | 2_29189528_C_T | 0.000680402 | 0.012550596 |
| 15 | PPFIBP1_1 | 12_27671307_G_A | 0.000932648 | 0.043451196 |
| 16 | GNG12_1 | 1_67707581_C_T | 0.000988807 | 0.022170841 |
| 17 | MATN3_1 | 2_20002159_T_TACAC | 0.000997596 | 0.02071966 |
| 18 | LAMA5_1 | 20_62325178_T_C | 0.001153135 | 0.010970602 |
| 19 | SECISBP2_1 | 9_89319872_A_G | 0.001203729 | 0.020014055 |
| 20 | CARD10_1 | 22_37506170_T_C | 0.001543214 | 0.032625328 |
| 21 | CELF3_1 | 1_151714507_T_A | 0.001901287 | 0.026406472 |
| 22 | RPRD2_1 | 1_150470594_A_C | 0.002054115 | 0.049994398 |
| 23 | LONP1_1 | 19_5707040_C_G | 0.002145064 | 0.014919269 |
| 24 | CELSR1_1 | 22_46397746_T_G | 0.002174791 | 0.029193759 |
| 25 | AVPI1_1 | 10_97677649_A_G | 0.002288252 | 0.001581419 |
| 26 | HEATR5A_1 | 14_31321626_G_C | 0.002664426 | 0.037377577 |
| 27 | ABCC3_1 | 17_50687493_T_G | 0.002687235 | 0.008875192 |
| 28 | BCL9L_1 | 11_118897861_A_C | 0.003330363 | 0.034238861 |
| 29 | ATP9A_1 | 20_51712877_T_C | 0.003711948 | 0.007942465 |
| 30 | PPL_1 | 16_4899248_T_G | 0.003916476 | 0.036032874 |
| 31 | WTIP_1 | 19_34482571_G_A | 0.004231715 | 0.04930162 |
| 32 | SEC11C_1 | 18_59152698_T_C | 0.004414812 | 0.00225746 |
| 33 | RIN2_1 | 20_19990244_G_A | 0.004460992 | 0.013004393 |
| 34 | VPS13C_1 | 15_61910091_C_T | 0.004506626 | 0.031208891 |
| 35 | WAS_1 | X_48691219_A_C | 0.004569497 | 0.02612273 |
| 36 | ITGA2_1 | 5_53062931_TA_T | 0.005690843 | 0.016066848 |
| 37 | SNX6_1 | 14_34581380_G_T | 0.006210652 | 0.003379828 |
| 38 | ITGB5_1 | 3_124769064_T_G | 0.006500498 | 0.000658854 |
| 39 | KIF13A_1 | 6_17796543_CTT_C | 0.006766834 | 0.022643788 |
| 40 | HNRNPD_1 | 4_82373387_A_G | 0.006955259 | 0.035424294 |
| 41 | PDE7A_1 | 8_65724444_TATAA_T | 0.006982791 | 0.049491005 |
| 42 | TAB1_1 | 22_39417620_CA_C | 0.007324331 | 0.041922448 |
| 43 | TSPAN17_1 | 5_176657159_A_G | 0.009147394 | 0.031164715 |
| 44 | MYO1C_1 | 17_1484178_C_T | 0.009858187 | 0.007802374 |
| 45 | CDC42BPA_1 | 1_227318293_C_CG | 0.010493359 | 0.000358115 |
| 46 | ACTN4_1 | 19_38728028_T_G | 0.011156467 | 0.005408687 |
| 47 | MET_1 | 7_116757685_T_G | 0.012677621 | 5.06E-05 |
| 48 | GPC1_1 | 2_240451010_T_G | 0.013814172 | 0.00346274 |
| 49 | HERC1_1 | 15_63725445_C_A | 0.014048274 | 0.007901005 |
| 50 | RAB13_1 | 1_153982198_T_C | 0.015384036 | 0.007436568 |
| 51 | UBE2N_1 | 12_93411182_C_T | 0.015885474 | 1.51E-06 |
| 52 | STRBP_1 | 9_123266116_C_G | 0.017136074 | 0.001078377 |
| 53 | EZH1_1 | 17_42729015_C_CA | 0.018478925 | 0.00312166 |
| 54 | RNASEH2B_1 | 13_50956394_G_T | 0.01852788 | 0.005925233 |
| 55 | LTBP3_1 | 11_65547976_T_G | 0.019306265 | 0.001002058 |
| 56 | EGFR_1 | 7_55205662_A_C | 0.020078083 | 0.000779757 |
| 57 | LPIN3_1 | 20_41358465_C_G | 0.020089538 | 6.89E-05 |
| 58 | PHF21A_1 | 11_46079428_CT_C | 0.020895851 | 0.00265565 |
| 59 | SPR_1 | 2_72891611_A_C | 0.021434042 | 0.000101783 |
| 60 | RCHY1_1 | 4_75509142_T_A | 0.022232183 | 7.00E-06 |
| 61 | EPHA2_1 | 1_16148437_A_C | 0.023495387 | 0.003022958 |
| 62 | GMEB1_1 | 1_28690201_G_T | 0.025608914 | 0.005247117 |
| 63 | KRI1_1 | 19_10565667_A_T | 0.026306225 | 2.71E-07 |
| 64 | MADD_1 | 11_47325027_T_C | 0.027877784 | 0.001497343 |
| 65 | ITGAV_1 | 2_186622542_G_T | 0.027935094 | 0.000708467 |
| 66 | FN1_1 | 2_215384980_GA_G | 0.028277863 | 0.006411138 |
| 67 | ITGB8_1 | 7_20404676_A_G | 0.03058173 | 0.00229404 |
| 68 | MYOF_1 | 10_93341723_C_T | 0.031403296 | 1.02E-05 |
| 69 | MICALL1_1 | 22_37911902_T_C | 0.031573614 | 0.005136303 |
| 70 | TXNL4A_1 | 18_80033872_T_C | 0.035325542 | 0.000843174 |
| 71 | AHR_1 | 7_17339074_A_C | 0.036910472 | 0.009928124 |
| 72 | HCFC1_1 | X_153963207_T_G | 0.040430125 | 0.001579155 |
| 73 | TJP1_1 | 15_29761137_A_C | 0.040841908 | 0.005695684 |
| 74 | DPF1_1 | 19_38216453_A_C | 0.041618699 | 0.002769532 |
| 75 | TUFT1_1 | 1_151565936_G_A | 0.042197322 | 0.004559558 |
| 76 | CNN3_1 | 1_94903018_TA_T | 0.044343955 | 0.002044509 |
| 77 | CALD1_1 | 7_134891710_CTT_C | 0.044361406 | 0.006749784 |
| 78 | DCP1A_1 | 3_53342054_G_C | 0.044944752 | 0.003471409 |
| 79 | CNBP_1 | 3_129183756_G_T | 0.045255004 | 0.001660507 |
| 80 | CDC42BPB_1 | 14_102952453_T_G | 0.046084899 | 0.003315245 |
| 81 | ZNF557_2 | 19_7083618_A_G / 19_7083750_A_G | 0.00011707290070365984 / 6.389914683218769e-05 | 1.6329734686551152e-07 / 4.640996358288638e-07 |
| 82 | TSC22D1_2 | 13_44574373_G_T / 13_44436480_G_A | 0.00011795878001107085 / 0.0037018440403040202 | 0.0064804726533923464 / 0.03180017409101453 |
| 83 | KDM2B_2 | 12_121579943_C_CA / 12_121444386_T_G | 0.0001937979358872413 / 0.00792596940180308 | 0.01794421156168876 / 0.019501973878425127 |
| 84 | TMEM206_3 | 1_212365230_C_T / 1_212377513_G_A / 1_212377773_C_T | 0.00020121681284993422 / 0.0003349904631200686 / 5.8829810838971604e-05 | 0.015527989364148976 / 0.03220676605475732 / 0.012309846725869236 |
| 85 | CNOT10_2 | 3_32727933_TAA_T / 3_32704796_GT_G | 0.0004336510041481753 / 0.008993061026214434 | 0.009535253937430231 / 0.00725632017358903 |
| 86 | AHNAK2_6 | 14_104939818_T_C / 14_104947943_T_G / 14_104955559_A_C / 14_104949306_T_C / 14_104950989_T_C / 14_104944923_A_G | 0.0013733032135289033 / 9.993054536650758e-05 / 0.0009826292819827367 / 0.008303598761450906 / 0.009151781473220755 / 0.016815570915054142 | 0.0009255099251631373 / 0.014057846162243957 / 0.00506490504122054 / 0.005256944789299486 / 0.039201386575838416 / 0.004782218518041667 |
| 87 | HNRNPH1_2 | 5_179614784_GAAAAA_G / 5_179616992_TA_T | 0.0015622332101704927 / 0.013101283499781437 | 0.009729395921872941 / 0.006282233288170697 |
| 88 | KCTD11_2 | 17_7355768_G_A / 17_7353417_T_G | 0.0021551269324258863 / 0.011987917410278012 | 0.042125567363077016 / 0.0012683162409826913 |
| 89 | DCBLD2_2 | 3_98800637_G_A / 3_98822022_G_A | 0.002171037536345973 / 0.000251692831370466 | 0.02405283820151249 / 0.02321925017861924 |
| 90 | MICALL2_6 | 7_1434706_A_T / 7_1436884_C_A / 7_1436960_A_G / 7_1434574_G_A / 7_1438692_G_A / 7_1438940_G_A | 0.0035785281207345704 / 0.005806506395454868 / 0.0023336782590812483 / 0.003953693182824404 / 0.01322256820373324 / 0.01322256820373324 | 0.03116600791585888 / 0.020144032243767682 / 0.0387968938865376 / 0.018579241850634483 / 0.001706040259270731 / 0.001706040259270731 |
| 91 | YEATS4_3 | 12_69360050_G_A / 12_69360067_T_C / 12_69359732_G_C | 0.004863813186856697 / 0.017375818716536366 / 0.03137776422130159 | 0.00020734016607029562 / 9.576513142549652e-05 / 0.00015854860163792644 |
| 92 | FAM129B_2 | 9_127505498_C_G / 9_127507507_A_G | 0.0058285941972244645 / 0.02690463941303876 | 0.011307547073529664 / 0.009068416405751362 |
| 93 | DAZAP1_2 | 19_1432575_T_C / 19_1434836_G_C | 0.007270894232908141 / 0.04710249822900437 | 0.008783799588482919 / 0.0025498805972486143 |
| 94 | TRIO_2 | 5_14390880_CT_C / 5_14489165_TA_T | 0.008880626014071066 / 0.01650056581622358 | 7.026077789590974e-05 / 0.0025442006562780626 |
| 95 | LTBR_2 | 12_6385217_T_C / 12_6385074_A_G | 0.009079148191429435 / 0.006460458599235777 | 9.805545850814532e-05 / 0.044833733345219534 |
| 96 | CRIM1_2 | 2_36479368_G_C / 2_36441370_A_C | 0.009119609813496462 / 0.019906184227680684 | 0.012444715286562538 / 0.003648330338783967 |
| 97 | LRRC1_2 | 6_53795560_C_T / 6_53922469_G_C | 0.01198676814286411 / 0.0006843529222630762 | 0.000908035692517222 / 0.04843244804719673 |
| 98 | PLEC_3 | 8_143935900_T_G / 8_143916360_A_G / 8_143919099_A_G | 0.014640529544546175 / 0.009983558087568838 / 0.034402276881097434 | 0.0004960012901022363 / 0.00910116635228719 / 0.0010288222361061275 |
| 99 | CCAR1_4 | 10_68737725_A_G / 10_68749117_T_C / 10_68786466_C_T / 10_68747145_CT_C | 0.01483460962771855 / 0.019812419206917474 / 0.021724978822350548 / 0.012199365670034771 | 0.007861846127742463 / 0.007748422295395019 / 0.009002153564015953 / 0.007417608363424872 |
| 100 | PBRM1_10 | 3_52550415_T_TCTC / 3_52550699_A_G / 3_52576635_T_A / 3_52603470_C_G / 3_52609291_A_G / 3_52658108_G_A / 3_52658343_C_G / 3_52642048_AC_A / 3_52642050_A_T / 3_52658412_CTT_C | 0.015475400089384512 / 0.0016628718776702444 / 0.035404535122126136 / 0.013312042665148668 / 0.0242839606361519 / 0.02159841119723304 / 0.03729870903666122 / 0.025323429673084204 / 0.025323429673084204 / 0.0001941847064581337 | 0.0035430700286634563 / 0.0001926448792301472 / 0.007441673662340349 / 0.002758979013645352 / 0.0010612844220239503 / 0.004958532862731571 / 0.004683945580784586 / 0.00010786476378721626 / 0.00010786476378721626 / 0.04797045127180218 |
| 101 | EPAS1_2 | 2_46356096_C_A / 2_46375583_T_C | 0.01783131944184612 / 0.0010999393665466503 | 0.008349664569290316 / 0.024779624499683697 |
| 102 | MYL12B_2 | 18_3277079_C_A / 18_3261766_G_T | 0.02040887855273308 / 0.006963645724708455 | 0.0006636499143577351 / 0.002628020597022407 |
| 103 | ASPH_3 | 8_61578734_T_G / 8_61642872_G_A / 8_61638365_TA_T | 0.02703041744922913 / 0.04217140046834995 / 0.0037026849241301204 | 0.00027481062695969863 / 9.242250914202104e-05 / 0.0033421074285719613 |
| 104 | CTTN_2 | 11_70433765_G_C / 11_70433037_T_G | 0.028796315723836858 / 0.0215077683383786 | 0.008528354106314544 / 0.004388396641544275 |
| 105 | GBP3_2 | 1_89009135_A_G / 1_89013185_G_A | 0.03712796271516626 / 0.046403726190448136 | 2.531316619591342e-10 / 0.003766535351837685 |
| 106 | RBM6_3 | 3_50077082_C_T / 3_50066484_G_A / 3_50075273_C_A | 0.03754138190716002 / 0.009406589543431777 / 0.006286329345703225 | 4.469564601606787e-06 / 0.014325869585835831 / 0.04790544676634136 |
| 107 | GULP1_2 | 2_188589974_C_CT / 2_188569425_C_A | 0.04155742757047321 / 0.00797269939608827 | 0.004507263398919969 / 0.006203700518672077 |
| 108 | RAI14_2 | 5_34822821_T_C / 5_34795871_A_G | 6.659980942617595e-05 / 0.005987810799744655 | 0.002995737088482826 / 0.006423617908157835 |
[표 16]에는 CHROMATIN 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 16]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 38에는 [표 16]에 기재된 바이오마커들 중 주요 바이오마커들의 CHROMATIN 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Variants(마커) | Var_Drug(pval) | Var_Exp(Pval) |
| 1 | SPR_1 | 2_72891611_A_C | 1.13E-09 | 0.000101783 |
| 2 | BCL9L_1 | 11_118897861_A_C | 3.13E-08 | 0.034238861 |
| 3 | ZDHHC7_1 | 16_84981848_T_G | 1.25E-07 | 0.007398316 |
| 4 | CCDC69_1 | 5_151185396_T_C | 2.83E-07 | 0.005439839 |
| 5 | DDX60_1 | 4_168220820_G_T | 4.91E-07 | 0.047715445 |
| 6 | RASSF5_1 | 1_206507640_A_C | 6.00E-07 | 0.042432506 |
| 7 | C21orf58_1 | 21_46302477_A_G | 5.32E-06 | 0.028316032 |
| 8 | KIAA0922_1 | 4_153466445_G_C | 1.35E-05 | 0.014460739 |
| 9 | NR2F2_1 | 15_96331144_C_T | 1.41E-05 | 0.041165877 |
| 10 | WWC2_1 | 4_183261395_G_T | 2.29E-05 | 0.017749371 |
| 11 | ERRFI1_1 | 1_8013331_A_G | 3.34E-05 | 0.000188249 |
| 12 | KIAA1191_1 | 5_176361895_T_C | 4.29E-05 | 0.02279099 |
| 13 | QSOX1_1 | 1_180196892_T_G | 5.61E-05 | 0.048904626 |
| 14 | NTN4_1 | 12_95683554_A_C | 5.86E-05 | 0.007698614 |
| 15 | KIFC3_1 | 16_57765532_T_G | 6.78E-05 | 0.038497261 |
| 16 | LPP_1 | 3_188484677_T_G | 7.25E-05 | 0.027828249 |
| 17 | TUFT1_1 | 1_151565936_G_A | 8.20E-05 | 0.004559558 |
| 18 | CDC14B_1 | 9_96496393_T_TACC | 0.000102442 | 0.034844355 |
| 19 | DTX1_1 | 12_113093500_A_T | 0.000105094 | 0.02107386 |
| 20 | P4HA2_1 | 5_132227207_C_T | 0.000133282 | 0.048816114 |
| 21 | ARHGAP25_1 | 2_68818005_T_G | 0.000231771 | 0.004043302 |
| 22 | TIMM13_1 | 19_2425296_G_C | 0.000236058 | 0.025389471 |
| 23 | CAST_1 | 5_96741643_A_C | 0.000249549 | 0.007284203 |
| 24 | PTPN12_1 | 7_77627576_G_C | 0.000317226 | 0.012844299 |
| 25 | MED28_1 | 4_17614675_T_G | 0.000322999 | 0.029816577 |
| 26 | SLC35F5_1 | 2_113723196_TA_T | 0.000333219 | 0.009792442 |
| 27 | TPBG_1 | 6_82364929_T_C | 0.000334942 | 0.003828919 |
| 28 | CD79B_1 | 17_63932334_A_C | 0.000528438 | 0.048052988 |
| 29 | DIRC2_1 | 3_122856322_A_G | 0.000825084 | 0.013416691 |
| 30 | UEVLD_1 | 11_18558312_C_A | 0.000960879 | 0.026771319 |
| 31 | LRP10_1 | 14_22875577_A_C | 0.001001744 | 0.013008771 |
| 32 | UGDH_1 | 4_39504307_CA_C | 0.001468644 | 0.048378289 |
| 33 | VMP1_1 | 17_59841357_A_C | 0.001495454 | 0.00700708 |
| 34 | DOT1L_1 | 19_2190948_TTGG_T | 0.001590625 | 0.039142783 |
| 35 | OSMR_1 | 5_38933647_C_T | 0.001601244 | 0.048095084 |
| 36 | CYR61_1 | 1_85581605_TA_T | 0.001618999 | 0.000620768 |
| 37 | EMP1_1 | 12_13211531_T_G | 0.001632317 | 0.001600571 |
| 38 | PRDM2_1 | 1_13781628_C_T | 0.001853506 | 0.028812792 |
| 39 | UBE2N_1 | 12_93411182_C_T | 0.001919604 | 1.51E-06 |
| 40 | PDE7A_1 | 8_65724444_TATAA_T | 0.001930609 | 0.049491005 |
| 41 | ZNF775_1 | 7_150397765_G_A | 0.002410672 | 0.02103353 |
| 42 | ACSS2_1 | 20_34920910_T_G | 0.002415783 | 0.038456731 |
| 43 | TNRC6C_1 | 17_78049826_A_C | 0.002419277 | 0.037719795 |
| 44 | OPTN_1 | 10_13108909_T_C | 0.002658339 | 0.009854403 |
| 45 | FHL2_1 | 2_105398737_G_C | 0.002849654 | 0.020214714 |
| 46 | TSR2_1 | X_54440646_T_G | 0.003023868 | 0.016676081 |
| 47 | PON2_1 | 7_95406313_A_C | 0.003172125 | 9.37E-06 |
| 48 | RIN2_1 | 20_19990244_G_A | 0.003495398 | 0.013004393 |
| 49 | ACVR1_1 | 2_157780624_GA_G | 0.003989606 | 0.003394881 |
| 50 | ARRB2_1 | 17_4720324_T_G | 0.004024916 | 0.04522165 |
| 51 | STRBP_1 | 9_123266116_C_G | 0.005108062 | 0.001078377 |
| 52 | APLP2_1 | 11_130110790_G_A | 0.006767893 | 0.002129537 |
| 53 | PPM1D_1 | 17_60656555_C_G | 0.007483948 | 0.004279928 |
| 54 | MICALL2_1 | 7_1442358_T_G | 0.008296918 | 0.00384944 |
| 55 | SDC4_1 | 20_45330303_T_G | 0.00885313 | 0.000496261 |
| 56 | MAP4K1_1 | 19_38617327_T_G | 0.009035501 | 0.013203631 |
| 57 | DDX51_1 | 12_132144264_G_A | 0.00950629 | 0.039746501 |
| 58 | CD63_1 | 12_55725568_A_C | 0.010191282 | 0.006277176 |
| 59 | TSEN34_1 | 19_54192354_T_G | 0.015320711 | 0.001848481 |
| 60 | RND3_1 | 2_150487464_GA_G | 0.016355986 | 0.009852344 |
| 61 | DYNC1LI2_1 | 16_66723584_GTTT_G | 0.020987801 | 0.00547115 |
| 62 | ATG4D_1 | 19_10547046_A_G | 0.025677384 | 0.001170719 |
| 63 | TEAD4_1 | 12_3019250_C_T | 0.025841261 | 0.001625407 |
| 64 | SPATS2L_1 | 2_200329386_C_A | 0.025958546 | 0.003348759 |
| 65 | TCF3_1 | 19_1627423_T_C | 0.04297822 | 0.006623288 |
| 66 | GPX8_1 | 5_55164338_T_C | 0.043500083 | 0.000150103 |
| 67 | CHD7_1 | 8_60781091_A_C | 0.049386713 | 0.009144258 |
| 68 | IQCB1_1 | 3_121788568_C_T | 0.049430015 | 1.56E-06 |
| 69 | CD84_2 | 1_160549875_A_G / 1_160550877_C_G | 0.00011388443370850483 / 0.0007812325110491749 | 0.011914227680681896 / 0.04088607952168802 |
| 70 | GSN_2 | 9_121300011_T_G / 9_121321305_A_C | 0.00014939533964484881 / 0.03316947281106813 | 0.027350252864946387 / 0.0036521684936499576 |
| 71 | PTPRC_2 | 1_198703381_A_C / 1_198752063_T_C | 0.00016494389721910315 / 0.0013479983597789753 | 0.02703768662070396 / 0.04525193826667434 |
| 72 | DAG1_2 | 3_49531399_T_G / 3_49530812_A_G | 0.00020026524182288077 / 0.006009115344867996 | 0.000829773140052924 / 0.031395065099950874 |
| 73 | CLEC16A_3 | 16_11156556_C_A / 16_11060913_G_A / 16_11042191_C_G | 0.0002094249249848047 / 6.263351817687237e-07 / 0.000591215275919509 | 0.00562768771681351 / 0.001657798405900209 / 0.0008509758531100063 |
| 74 | SEMA3C_2 | 7_80748927_A_C / 7_80758439_T_G | 0.00023588106210457256 / 0.002402247845707725 | 0.04566908222348532 / 0.022537466343331126 |
| 75 | MYO1E_3 | 15_59272288_G_C / 15_59223315_G_A / 15_59138181_A_C | 0.0002531868313324391 / 0.017294701356675626 / 0.012353995820357604 | 0.006181875879725325 / 0.0073567891788311425 / 0.000506485287819266 |
| 76 | FBRSL1_2 | 12_132582046_C_T / 12_132490757_A_G | 0.0002541174963279791 / 0.0016132414574028821 | 0.017168862085872382 / 0.014332097218830869 |
| 77 | PLAUR_2 | 19_43665377_C_A / 19_43665506_A_C | 0.0004816822177162012 / 0.000329711238045009 | 0.013703989625456308 / 0.02821338934893095 |
| 78 | UPP1_2 | 7_48108129_C_G / 7_48108147_T_G | 0.0005053096271809359 / 0.032569834532674265 | 0.0002337913556195707 / 0.0015081620173450355 |
| 79 | TM4SF1_3 | 3_149375338_T_G / 3_149375342_T_G / 3_149375345_A_G | 0.0006450924297222392 / 0.00041880937510606033 / 0.0045963625050391855 | 0.00025288036755393063 / 0.005766354533635817 / 0.02993773631668 |
| 80 | ZNF430_4 | 19_21020746_C_T / 19_21022725_C_T / 19_21034405_A_G / 19_21022773_T_G | 0.0006475458714423392 / 0.0074498992574896375 / 0.001227492240630532 / 0.0008007999312255407 | 0.0014493947676260713 / 7.931044376997757e-06 / 0.043344266998276815 / 0.024171318376603662 |
| 81 | CYTIP_2 | 2_157427544_C_T / 2_157427198_A_G | 0.000837855207497095 / 0.004314698497827655 | 0.016967272956506692 / 0.0066627404504453576 |
| 82 | FAM129B_3 | 9_127531490_GA_G / 9_127525143_T_G / 9_127578821_C_G | 0.000922821517572468 / 0.0002411893320187629 / 8.276570085958934e-05 | 0.031013612085774283 / 0.010661251800502545 / 0.0009666899162254512 |
| 83 | SEC11C_2 | 18_59152698_T_C / 18_59139887_T_G | 0.0009260156067678403 / 0.049013482279269986 | 0.0022574597582570113 / 0.007830715004334495 |
| 84 | SERPINB6_3 | 6_2955641_A_C / 6_2955644_A_C / 6_2959401_A_C | 0.001043382693355795 / 0.024971781697072672 / 0.0010045092345408332 | 0.01355817950847752 / 0.003892754006925403 / 0.039976665559382514 |
| 85 | HEXB_5 | 5_74696581_T_G / 5_74696784_G_A / 5_74715459_CT_C / 5_74715716_T_A / 5_74715716_T_TA | 0.0011109425360834742 / 0.0004588063308077307 / 0.00032306189000466006 / 0.0012875359612772113 / 0.013801634858228495 | 0.0076182846696747 / 0.037654298343869685 / 0.0009700644073606587 / 0.0006894634360309071 / 0.008716125756790354 |
| 86 | CHAF1A_5 | 19_4431899_C_T / 19_4442339_C_T / 19_4443049_T_C / 19_4422720_A_G / 19_4442532_T_C | 0.0013371878989745694 / 4.704638650715319e-06 / 0.002601657035134123 / 0.00848724820837247 / 0.0008277326854784058 | 1.913287638550038e-06 / 2.142565869765625e-07 / 2.294297809586175e-06 / 0.024620616607439628 / 0.010330162535447171 |
| 87 | DTNBP1_5 | 6_15522870_T_C / 6_15662701_T_G / 6_15524467_T_C / 6_15637909_C_A / 6_15651411_GA_G | 0.00140727662017035 / 0.0007340285829190258 / 0.000563588210134313 / 0.0015365486679584585 / 0.012631556103580063 | 0.02838345350893315 / 0.001004314451212422 / 0.0038345211108275156 / 0.02038116210082405 / 0.0014349866138238813 |
| 88 | NPC1_6 | 18_23533587_A_G / 18_23531466_TG_T / 18_23543332_G_GA / 18_23556539_A_C / 18_23551637_T_C / 18_23540944_CT_C | 0.001437129484746987 / 7.150026947753571e-05 / 0.0029007221429512673 / 0.0002201554381797956 / 0.00283655966462793 / 0.003557570436749789 | 0.049542946772028126 / 0.03680603821841593 / 0.0011845211365567286 / 0.011218938268584914 / 0.00977392034448968 / 0.040822963170832685 |
| 89 | DCK_2 | 4_71023678_G_A / 4_71023683_A_T | 0.0025792753639569685 / 0.004519208391207111 | 0.0495745351142595 / 0.03292890320415958 |
| 90 | MYOF_5 | 10_93402739_A_T / 10_93341723_C_T / 10_93456833_C_T / 10_93359764_G_A / 10_93379679_T_C | 0.0031553117726987327 / 0.0003251886046767745 / 0.0012115888716542418 / 0.0011033881652818386 / 1.1152022033742226e-05 | 0.008275987890594253 / 1.0154009952651607e-05 / 4.5730649026336375e-05 / 0.04572104850464974 / 0.0006543495060757152 |
| 91 | CNOT6L_4 | 4_77720488_T_G / 4_77819455_A_C / 4_77720486_A_G / 4_77726534_A_C | 0.003413275456645043 / 0.004884718330098437 / 1.3017900050261066e-05 / 0.013675885143940456 | 0.00045440611666765506 / 0.0041059419980858354 / 0.003812687853894012 / 0.002323583718729919 |
| 92 | SNX24_2 | 5_122845530_G_A / 5_123023772_TA_T | 0.003825812212204896 / 0.005412166991196986 | 0.032851178784777335 / 0.010215103992736332 |
| 93 | SQSTM1_4 | 5_179833153_C_T / 5_179833213_G_A / 5_179822433_T_C / 5_179832842_G_C | 0.004089948495769615 / 0.007896407107059047 / 1.0391418374918043e-11 / 5.901642675392869e-07 | 0.014656854055438881 / 0.015290841042493631 / 0.0024949336391905503 / 0.0024314650981475784 |
| 94 | CTTN_7 | 11_70419876_A_C / 11_70419880_T_C / 11_70433755_A_G / 11_70433765_G_C / 11_70407283_C_T / 11_70433037_T_G / 11_70435435_C_T | 0.004793877560857165 / 0.0029267237988671235 / 0.0002662301400632249 / 2.1853977605406948e-05 / 5.710606729324503e-07 / 0.00010373335018763256 / 0.002764146814493288 | 0.00030309409522359497 / 0.003131141961303907 / 0.02047999046614251 / 0.008528354106314544 / 0.005941149857145408 / 0.004388396641544275 / 0.013709818259161087 |
| 95 | KDM2B_4 | 12_121580903_A_C / 12_121579943_C_CA / 12_121444386_T_G / 12_121580252_TG_T | 0.004804220239616889 / 5.298915204579247e-06 / 7.807472174797022e-08 / 0.024172279934987287 | 0.04290936139558865 / 0.01794421156168876 / 0.019501973878425127 / 0.004964292850525796 |
| 96 | CTNNA1_4 | 5_138812304_T_G / 5_138824633_A_C / 5_138933920_C_T / 5_138812289_C_G | 0.005041441550878414 / 0.009914746459480685 / 0.00032076772718977635 / 0.013542487211798218 | 0.013339032203366944 / 0.004284224604488671 / 0.00010488952235634391 / 0.0010251811268691103 |
| 97 | TRIOBP_2 | 22_37751927_A_C / 22_37757383_C_G | 0.0053165450762140245 / 0.0016386338499532257 | 0.008760146502383994 / 8.295724649894844e-05 |
| 98 | EGR1_2 | 5_138467153_A_C / 5_138466811_A_C | 0.005590395913285018 / 0.00018684738505679937 | 0.006707694887573882 / 0.00027393305226194143 |
| 99 | MYCBP2_8 | 13_77070727_G_A / 13_77165156_A_T / 13_77098982_T_G / 13_77051091_G_A / 13_77051098_A_C / 13_77058230_T_G / 13_77061586_T_C / 13_77267898_T_G | 0.008036895878308711 / 0.012181733375411912 / 0.0004449974043640469 / 0.0007742974469162077 / 0.004690941013903492 / 0.022811552981952272 / 0.0002327215378800939 / 0.004205585533754351 | 0.029852585169277374 / 0.00045980757332588846 / 0.0038229074053839733 / 0.00017518564876142542 / 4.397700485560215e-05 / 0.0032117224925540928 / 0.030373685856290068 / 0.00592396173483849 |
| 100 | TCF4_6 | 18_55464257_C_A / 18_55463971_TGTGTGTGA_T / 18_55275657_A_G / 18_55275664_A_G / 18_55403517_A_C / 18_55461237_G_T | 0.008090959269238968 / 0.0056178520760126974 / 0.001559758175866868 / 0.012472558742737408 / 0.0011862271176169732 / 0.006912522905586032 | 0.032420073593804284 / 0.03333184670009802 / 0.0013930308437610063 / 0.00619762753769391 / 1.5397131093463103e-06 / 0.04572000946513434 |
| 101 | LAMC1_3 | 1_183132309_A_C / 1_183131203_C_T / 1_183131172_CAA_C | 0.008181813089040216 / 3.4320876665108484e-05 / 0.02745630451997897 | 0.01655294869349123 / 0.03400723316751987 / 0.002417084109353407 |
| 102 | DCBLD2_2 | 3_98800637_G_A / 3_98822022_G_A | 0.00885632710582371 / 0.003195091628487625 | 0.02405283820151249 / 0.02321925017861924 |
| 103 | FAM114A1_2 | 4_38905545_G_A / 4_38905553_A_G | 0.008914101428030875 / 9.057397575383816e-05 | 0.004385515653682114 / 0.0017226027017899913 |
| 104 | RXRA_2 | 9_134379472_C_A / 9_134432274_T_C | 0.01212893284996885 / 0.0010613625702847742 | 0.008306707838893354 / 0.02628295923936911 |
| 105 | TXNL4A_2 | 18_80033872_T_C / 18_79988525_A_C | 0.013055851849266827 / 0.0007334523399616647 | 0.0008431735834914795 / 0.0008431735834914795 |
| 106 | PLOD1_3 | 1_11957799_T_G / 1_11958607_A_C / 1_11949823_T_G | 0.016423562694112787 / 0.0001256608005905079 / 0.00021455234639659347 | 0.008642421166450967 / 0.04289731210522306 / 0.033198246352540164 |
| 107 | ZBTB40_2 | 1_22508509_T_G / 1_22490438_G_C | 0.019306644087308318 / 0.0028404969140742 | 0.007412910007401148 / 0.034427044070664166 |
| 108 | LAMB1_4 | 7_107937003_CT_C / 7_107937011_T_C / 7_107932321_G_T / 7_107962914_G_C | 0.02001404015878396 / 0.03127808008490267 / 2.518001172595479e-05 / 0.001938778625683203 | 0.0036685711722291453 / 0.0056496711183904105 / 0.008417008915963444 / 0.03562871053322305 |
| 109 | ZNF407_2 | 18_74635526_T_C / 18_74631665_A_C | 0.02054827360868693 / 0.0027671214071800644 | 0.0030145474545959137 / 0.0007578348015755224 |
| 110 | PLK2_2 | 5_58457156_TA_T / 5_58459186_CA_C | 0.02678606136810066 / 0.011492772698233265 | 0.0067079016563832035 / 0.009712841903254471 |
| 111 | ITGAV_6 | 2_186622542_G_T / 2_186637080_T_G / 2_186637084_A_G / 2_186602110_C_T / 2_186665096_ATTT_A / 2_186665096_ATTT_AT | 0.02893229553935201 / 1.7690277512995773e-05 / 5.7650114136378393e-05 / 0.0008794014178128033 / 0.0009612996704148748 / 0.0001992070205841996 | 0.0007084667177580308 / 0.001139110475330106 / 0.032143834630956734 / 0.02901306245899837 / 0.02901306245899837 / 0.044847327779240435 |
| 112 | TPP2_4 | 13_102649187_G_T / 13_102654868_C_T / 13_102663598_G_C / 13_102663763_G_A | 0.03448812010250688 / 0.0477208297438401 / 0.019367023504440688 / 0.03879139461694567 | 0.0003388682906380855 / 0.0002674729630147893 / 5.0196213345567326e-05 / 0.0001694198597404117 |
| 113 | EGFR_2 | 7_55205133_G_A / 7_55205662_A_C | 0.03713506709789649 / 0.0018125796749231603 | 0.003745674667154008 / 0.0007797573368817686 |
| 114 | FAM57A_2 | 17_733080_T_TCTC / 17_733026_A_AGGGCC | 0.039798318296646464 / 0.015321230586696297 | 0.00016240672631849488 / 4.5958865963508443e-05 |
| 115 | RBFOX1_2 | 16_7676807_A_C / 16_7653705_T_G | 1.089283918433845e-06 / 0.009933638723622762 | 0.017746981967786752 / 0.040139058541755146 |
| 116 | PLEC_10 | 8_143935900_T_G / 8_143916360_A_G / 8_143917054_T_G / 8_143917234_T_G / 8_143918739_A_C / 8_143919099_A_G / 8_143925385_A_C / 8_143919088_C_G / 8_143927138_G_A / 8_143930017_C_T | 1.2060887811693293e-09 / 0.0045339553290741135 / 0.000104533588224814 / 1.7757593439950334e-05 / 0.00011641011921845986 / 1.9686417676937634e-05 / 0.006102754107095385 / 0.01695040934478527 / 0.039180192965724406 / 0.017591680187249745 | 0.0004960012901022363 / 0.00910116635228719 / 0.025072704488480143 / 0.013279688389245713 / 2.138708286444241e-05 / 0.0010288222361061275 / 0.0062995698781779215 / 0.009415988048366521 / 0.008162873576760793 / 0.001268625363946227 |
| 117 | ACTN1_2 | 14_68904620_A_G / 14_68879945_C_A | 2.2790061519900746e-05 / 0.002826959920374089 | 0.01924890787722053 / 0.03820518094606298 |
| 118 | YES1_2 | 18_724697_A_C / 18_732727_A_G | 2.3090624801719088e-05 / 0.007129044591559579 | 0.008883311549914912 / 0.026256278963938562 |
| 119 | SMARCC1_2 | 3_47662444_T_G / 3_47735913_C_T | 2.3383243293118917e-06 / 0.002421910157609216 | 0.0017680794934126945 / 0.01814701077813162 |
| 120 | LMNA_2 | 1_156139242_AT_A / 1_156138783_A_G | 2.3951192128687798e-05 / 0.0022551444971150103 | 0.04237931129547261 / 0.040758441980734486 |
| 121 | CCND1_2 | 11_69650913_A_G / 11_69651969_C_G | 2.86821845503723e-06 / 0.0004216841283241181 | 0.024298615321604846 / 0.021515769887785408 |
| 122 | SMARCA4_3 | 19_11025539_C_G / 19_11025639_C_T / 19_11059900_G_C | 3.0403566208171576e-05 / 9.60336281664007e-06 / 0.00028978302130045137 | 0.00029624992802644123 / 0.02706216606857304 / 0.035243495124704975 |
| 123 | KMT2C_7 | 7_152273692_G_A / 7_152235860_C_T / 7_152145265_T_G / 7_152152848_C_A / 7_152177504_T_G / 7_152236218_G_A / 7_152152869_A_G | 4.1091183934080156e-05 / 0.03814263508657298 / 0.010803753158495692 / 0.018128565763915704 / 0.001183790631102062 / 0.008327722660599219 / 0.017441444102837326 | 0.02044755694417402 / 0.00015664974968742393 / 0.0030671124260532785 / 0.00028670765106413883 / 0.0007976241891358237 / 0.0009326888762057726 / 0.008191480303636886 |
| 124 | PXN_2 | 12_120219856_A_C / 12_120219864_A_C | 4.578278108445838e-05 / 0.0074220837424624425 | 0.0003630643828121584 / 0.0023389819820739933 |
| 125 | BCOR_2 | X_40052275_A_C / X_40074609_T_G | 4.939704915952993e-09 / 0.0027449638737320047 | 0.00020414397606395237 / 0.02744186131378764 |
| 126 | FLI1_2 | 11_128810729_A_G / 11_128810736_G_C | 5.306393173162265e-05 / 0.004212940238900314 | 1.6562593178924343e-05 / 1.4658089385344776e-05 |
| 127 | LAMB2_4 | 3_49121431_A_C / 3_49126013_T_G / 3_49125146_T_G / 3_49121239_T_G | 5.5170807525836925e-05 / 0.03902097870402451 / 7.419230761410297e-05 / 0.003164093062093864 | 2.9470349723526757e-05 / 0.002569958840604656 / 0.002569958840604656 / 0.028556312248339717 |
| 128 | HMGA2_2 | 12_65841991_CT_C / 12_65838525_G_A | 5.57550946086e-05 / 0.039914434884169736 | 0.032926686839147117 / 0.00575414262140414 |
| 129 | ZNF708_3 | 19_21294577_C_T / 19_21309149_T_A / 19_21309260_G_A | 5.694223127781568e-05 / 9.010844850080123e-06 / 0.0003481251422158083 | 0.007544201865148675 / 0.008126720123629898 / 4.891895383413758e-05 |
| 130 | ASPH_2 | 8_61578734_T_G / 8_61578968_A_C | 6.56790692451237e-08 / 0.0009758798617439217 | 0.00027481062695969863 / 0.0029272870469332557 |
| 131 | CCAR1_5 | 10_68737016_C_A / 10_68736998_A_C / 10_68747386_A_C / 10_68749170_A_C / 10_68747145_CT_C | 8.229773536774104e-06 / 0.007146867657347806 / 0.0011117731660420908 / 0.0013852137674061765 / 0.003664158474067453 | 0.003954046326130957 / 0.005283569468845993 / 0.002868590533518923 / 0.044268019704288585 / 0.007417608363424872 |
| 132 | DOCK1_3 | 10_127008567_ATAACT_A / 10_127248024_G_T / 10_127414990_T_G | 9.077419985352092e-05 / 0.0002745710836507499 / 0.00705137247255559 | 0.0011610761862802675 / 0.020184142497530616 / 0.047170945666414485 |
[표 17]에는 EGRF 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 17]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 39에는 [표 17]에 기재된 바이오마커들 중 주요 바이오마커들의 EGRF 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Variants(마커) | Var_Drug(pval) | Var_Exp(Pval) |
| 1 | CWC27_1 | 5_64977191_G_A | 2.20E-08 | 0.002090721 |
| 2 | RNF217_1 | 6_125082793_A_C | 3.96E-08 | 0.0374208 |
| 3 | PTGR1_1 | 9_111597344_C_A | 8.25E-08 | 2.15E-05 |
| 4 | NTN4_1 | 12_95738117_A_G | 1.53E-07 | 0.019702457 |
| 5 | ZNF276_1 | 16_89737928_T_C | 1.72E-07 | 0.019670045 |
| 6 | THBS1_1 | 15_39587486_A_C | 2.59E-07 | 0.031233094 |
| 7 | TRIM29_1 | 11_120115474_C_A | 3.52E-07 | 0.011023929 |
| 8 | APBB1_1 | 11_6401118_A_C | 7.48E-07 | 0.04449344 |
| 9 | RASA3_1 | 13_113981629_G_A | 1.35E-06 | 0.009453296 |
| 10 | TMX3_1 | 18_68700489_TA_T | 1.39E-06 | 0.003224589 |
| 11 | RRP1_1 | 21_43791417_C_A | 1.65E-06 | 0.034182877 |
| 12 | SIT1_1 | 9_35650461_G_A | 1.75E-06 | 0.019947873 |
| 13 | FRG1_1 | 4_189955114_T_C | 2.25E-06 | 0.018901776 |
| 14 | GTF2IRD1_1 | 7_74512993_A_G | 3.54E-06 | 0.006481631 |
| 15 | DCP1A_1 | 3_53342054_G_C | 4.78E-06 | 0.003471409 |
| 16 | SNRNP70_1 | 19_49101556_A_C | 5.20E-06 | 0.016599779 |
| 17 | DDX20_1 | 1_111756207_T_C | 5.26E-06 | 0.008003234 |
| 18 | TJP2_1 | 9_69237088_T_C | 5.58E-06 | 0.04386431 |
| 19 | RHOJ_1 | 14_63269236_T_G | 6.18E-06 | 0.027885215 |
| 20 | CXCL2_1 | 4_74098975_A_C | 7.13E-06 | 0.000838562 |
| 21 | CARD8_1 | 19_48212012_T_C | 9.03E-06 | 0.00020501 |
| 22 | TRMT2A_1 | 22_20117296_A_C | 9.03E-06 | 0.048556634 |
| 23 | CRIM1_1 | 2_36479368_G_C | 9.53E-06 | 0.012444715 |
| 24 | ELF3_1 | 1_202010991_C_G | 9.65E-06 | 0.017391595 |
| 25 | UHRF2_1 | 9_6482002_G_T | 1.20E-05 | 0.007025127 |
| 26 | HDHD2_1 | 18_47115026_C_T | 1.42E-05 | 1.48E-06 |
| 27 | ZBTB17_1 | 1_15944765_G_A | 1.47E-05 | 0.010171388 |
| 28 | THRB_1 | 3_24143504_G_A | 1.80E-05 | 0.026515077 |
| 29 | DHRS3_1 | 1_12568430_G_A | 1.81E-05 | 0.043238329 |
| 30 | AGTPBP1_1 | 9_85672687_TA_T | 1.94E-05 | 0.017580094 |
| 31 | DMTF1_1 | 7_87166631_TAG_T | 1.97E-05 | 0.010040428 |
| 32 | CTBP2_1 | 10_124993226_T_G | 2.02E-05 | 0.022707139 |
| 33 | BLK_1 | 8_11543171_G_A | 2.24E-05 | 0.01145612 |
| 34 | EPCAM_1 | 2_47373742_AT_A | 2.57E-05 | 0.033377716 |
| 35 | JUN_1 | 1_58782229_T_C | 2.65E-05 | 0.037758558 |
| 36 | RBM5_1 | 3_50114164_G_T | 2.77E-05 | 0.00111984 |
| 37 | CDKN2AIP_1 | 4_183445476_T_TGCACA | 2.77E-05 | 0.002734488 |
| 38 | ZCCHC7_1 | 9_37302158_C_T | 2.93E-05 | 0.022389727 |
| 39 | RAB8B_1 | 15_63262625_GTA_G | 2.96E-05 | 0.020562837 |
| 40 | ODC1_1 | 2_10444350_A_C | 2.98E-05 | 0.031377929 |
| 41 | CLTB_1 | 5_176397682_T_C | 3.11E-05 | 0.006127908 |
| 42 | UIMC1_1 | 5_176906125_C_T | 3.66E-05 | 0.014840456 |
| 43 | HCST_1 | 19_35903545_A_C | 3.71E-05 | 0.031562304 |
| 44 | HSPA1B_1 | 6_31828722_C_G | 3.82E-05 | 0.018774385 |
| 45 | MYL12B_1 | 18_3261766_G_T | 4.16E-05 | 0.002628021 |
| 46 | RHBDF1_1 | 16_63885_G_GCC | 4.21E-05 | 0.04101508 |
| 47 | UBE2N_1 | 12_93411182_C_T | 4.29E-05 | 1.51E-06 |
| 48 | SVIL_1 | 10_29524582_A_G | 4.44E-05 | 0.010981597 |
| 49 | CCDC28B_1 | 1_32202026_A_C | 4.45E-05 | 0.031117706 |
| 50 | ADARB1_1 | 21_45182568_CT_C | 4.48E-05 | 0.049945862 |
| 51 | PPP4R1_1 | 18_9549876_A_G | 5.09E-05 | 0.004893788 |
| 52 | CHD1L_1 | 1_147294440_C_G | 5.10E-05 | 0.048656291 |
| 53 | LRP5_1 | 11_68424878_T_G | 5.20E-05 | 0.010363624 |
| 54 | RND3_1 | 2_150487464_GA_G | 5.77E-05 | 0.009852344 |
| 55 | LONRF1_1 | 8_12731670_C_A | 5.98E-05 | 0.001411904 |
| 56 | BCOR_1 | X_40052275_A_C | 6.09E-05 | 0.000204144 |
| 57 | CCT8_1 | 21_29070160_C_T | 6.54E-05 | 0.02571665 |
| 58 | ZNF330_1 | 4_141232702_CTT_C | 8.61E-05 | 0.012329326 |
| 59 | CEP128_1 | 14_80916501_C_A | 8.82E-05 | 0.001156052 |
| 60 | SH2D3A_1 | 19_6760997_A_G | 9.99E-05 | 0.028745239 |
| 61 | IRF6_1 | 1_209790735_C_T | 0.000103095 | 0.008136801 |
| 62 | ITGAL_1 | 16_30484175_C_T | 0.000109049 | 0.037227837 |
| 63 | UEVLD_1 | 11_18558312_C_A | 0.000112934 | 0.026771319 |
| 64 | RNF141_1 | 11_10530725_T_C | 0.000116417 | 0.011923468 |
| 65 | THRAP3_1 | 1_36288866_G_C | 0.000117571 | 0.000131738 |
| 66 | PIAS4_1 | 19_4028785_C_T | 0.000120052 | 0.024864531 |
| 67 | SLC22A5_1 | 5_132390655_C_A | 0.000123083 | 0.004292176 |
| 68 | JAG1_1 | 20_10648877_T_C | 0.00012714 | 0.02148436 |
| 69 | SPI1_1 | 11_47358510_A_C | 0.000133865 | 0.03491009 |
| 70 | TECPR1_1 | 7_98223587_A_G | 0.000136841 | 0.023100583 |
| 71 | ZC3HC1_1 | 7_130023656_C_T | 0.000136956 | 0.010175357 |
| 72 | PDGFA_1 | 7_518698_G_C | 0.000139135 | 0.000252407 |
| 73 | C16orf74_1 | 16_85741569_G_A | 0.000148491 | 0.001823033 |
| 74 | DOT1L_1 | 19_2226677_G_A | 0.00015451 | 0.006191812 |
| 75 | CD19_1 | 16_28937656_A_C | 0.000155088 | 0.031114669 |
| 76 | P2RY2_1 | 11_73235099_G_C | 0.000158117 | 0.045669577 |
| 77 | EHF_1 | 11_34661000_T_C | 0.000158117 | 0.017992198 |
| 78 | EPS15L1_1 | 19_16392488_A_C | 0.000158117 | 0.033272384 |
| 79 | AGTRAP_1 | 1_11750007_T_G | 0.000159275 | 0.049159238 |
| 80 | LYRM7_1 | 5_131199511_CT_C | 0.000164473 | 0.021278948 |
| 81 | EPAS1_1 | 2_46346944_T_G | 0.000170063 | 0.018667654 |
| 82 | SIX4_1 | 14_60713618_C_T | 0.000180476 | 0.049844478 |
| 83 | PROM2_1 | 2_95281185_T_G | 0.000190311 | 0.033838771 |
| 84 | CAPN1_1 | 11_65186241_T_G | 0.000194914 | 0.02936405 |
| 85 | SRRM1_1 | 1_24669380_C_A | 0.000202713 | 0.019718891 |
| 86 | KLF3_1 | 4_38689006_A_C | 0.000228896 | 0.015121455 |
| 87 | THSD4_1 | 15_71765130_A_C | 0.000239788 | 1.95E-06 |
| 88 | GPR107_1 | 9_130129853_A_G | 0.000243505 | 0.033022802 |
| 89 | TCERG1_1 | 5_146471685_A_C | 0.000246294 | 0.042046343 |
| 90 | ATG4C_1 | 1_62805167_G_T | 0.000259178 | 0.028589986 |
| 91 | SHQ1_1 | 3_72750552_C_T | 0.000259737 | 0.005940284 |
| 92 | DSG2_1 | 18_31524751_A_G | 0.000261765 | 0.009944093 |
| 93 | S100A14_1 | 1_153615226_C_T | 0.000274681 | 0.01787459 |
| 94 | CLDN4_1 | 7_73830773_C_T | 0.000293995 | 0.000682466 |
| 95 | OVOL2_1 | 20_18041767_A_G | 0.000295117 | 0.047118131 |
| 96 | CREB1_1 | 2_207577759_AT_A | 0.00029854 | 0.000463006 |
| 97 | BCLAF1_1 | 6_136278266_T_C | 0.000301864 | 6.60E-05 |
| 98 | PKP2_1 | 12_32791480_G_T | 0.000343509 | 0.006486331 |
| 99 | ADAM9_1 | 8_39082624_ATTT_A | 0.000344695 | 0.022961 |
| 100 | POLA1_1 | X_24743203_T_G | 0.000351661 | 0.028975018 |
| 101 | FBXO10_1 | 9_37537560_G_A | 0.000376887 | 0.024540631 |
| 102 | CHMP4B_1 | 20_33811394_C_G | 0.000388769 | 0.00409862 |
| 103 | NOP56_1 | 20_2657708_GT_G | 0.000405654 | 0.000313483 |
| 104 | WIPF1_1 | 2_174585550_T_G | 0.000407518 | 0.000483959 |
| 105 | SCNN1A_1 | 12_6349108_G_C | 0.00042455 | 0.003465155 |
| 106 | C11orf80_1 | 11_66828178_C_T | 0.000427492 | 0.010017428 |
| 107 | ERP27_1 | 12_14914577_T_TGTGC | 0.000433389 | 0.018734323 |
| 108 | JAG2_1 | 14_105151295_T_G | 0.000452695 | 0.00756224 |
| 109 | SMARCC1_1 | 3_47693210_A_G | 0.00046021 | 6.92E-05 |
| 110 | RNF138_1 | 18_32123591_T_C | 0.000469129 | 0.018606829 |
| 111 | THYN1_1 | 11_134248640_G_T | 0.000477172 | 0.042214253 |
| 112 | CYP24A1_1 | 20_54164725_T_C | 0.000480706 | 0.013922674 |
| 113 | SH2D3C_1 | 9_127766923_A_C | 0.000489816 | 0.042455713 |
| 114 | TGFA_1 | 2_70453242_T_G | 0.000497539 | 0.011508647 |
| 115 | CXCL16_1 | 17_4738773_T_G | 0.000507631 | 0.000457547 |
| 116 | AEN_1 | 15_88629905_A_C | 0.000523617 | 0.014580971 |
| 117 | SLC37A1_1 | 21_42534616_T_G | 0.00054592 | 0.025393921 |
| 118 | EPHA2_1 | 1_16148437_A_C | 0.000564393 | 0.003022958 |
| 119 | BCS1L_1 | 2_218660859_A_G | 0.000567546 | 0.011564609 |
| 120 | FBXO43_1 | 8_100137711_G_C | 0.000602338 | 0.026281824 |
| 121 | ADAM22_1 | 7_88075657_C_T | 0.000632153 | 0.041287227 |
| 122 | ADAMTSL1_1 | 9_18636052_G_T | 0.000649915 | 0.010200615 |
| 123 | ATXN2L_1 | 16_28834263_C_T | 0.000652099 | 0.023519932 |
| 124 | ZCCHC4_1 | 4_25313024_A_C | 0.000669769 | 0.022993547 |
| 125 | BCL2_1 | 18_63318646_T_C | 0.000676626 | 0.021320439 |
| 126 | EGR1_1 | 5_138466811_A_C | 0.000686817 | 0.000273933 |
| 127 | HS3ST1_1 | 4_11399218_T_C | 0.000704542 | 0.027639734 |
| 128 | LEF1_1 | 4_108078210_G_A | 0.000716837 | 0.012727304 |
| 129 | SRSF7_1 | 2_38748190_GT_G | 0.000734347 | 0.005863144 |
| 130 | KHSRP_1 | 19_6415784_T_C | 0.000787917 | 0.003576751 |
| 131 | YPEL1_1 | 22_21704297_T_C | 0.000796764 | 0.006311112 |
| 132 | TAPT1_1 | 4_16162866_G_A | 0.000802167 | 0.000763967 |
| 133 | SNRK_1 | 3_43348277_C_T | 0.000817875 | 0.00952899 |
| 134 | UGCG_1 | 9_111932206_A_G | 0.000846657 | 0.012775358 |
| 135 | DBF4B_1 | 17_44709262_G_C | 0.000856709 | 0.025236345 |
| 136 | HOOK1_1 | 1_59860373_C_G | 0.000856894 | 0.041888498 |
| 137 | ITGB3BP_1 | 1_63572436_G_T | 0.000871324 | 0.023830002 |
| 138 | DTX4_1 | 11_59205028_T_C | 0.000886385 | 0.025332013 |
| 139 | PPP1R13L_1 | 19_45391868_T_C | 0.000894105 | 0.005877508 |
| 140 | CBLC_1 | 19_44790103_A_C | 0.000937082 | 0.025305244 |
| 141 | B4GALT4_1 | 3_119212822_G_T | 0.000987069 | 8.97E-06 |
| 142 | HSBP1_1 | 16_83809462_C_T | 0.000990234 | 0.008673739 |
| 143 | DTX1_1 | 12_113093500_A_T | 0.001029524 | 0.02107386 |
| 144 | TMEM51_1 | 1_15219789_A_C | 0.001061315 | 0.004570596 |
| 145 | ASAP2_1 | 2_9388476_A_C | 0.001065564 | 0.013740425 |
| 146 | PPP2R3C_1 | 14_35096667_C_A | 0.001070573 | 0.008848084 |
| 147 | WWC2_1 | 4_183280995_G_T | 0.001131955 | 0.017164588 |
| 148 | DMKN_1 | 19_35505819_C_T | 0.001187435 | 0.023762682 |
| 149 | EPHX1_1 | 1_225838589_T_G | 0.001193048 | 0.015600736 |
| 150 | PRPF4B_1 | 6_4051933_C_A | 0.001231599 | 0.023843897 |
| 151 | SNRNP40_1 | 1_31267793_A_G | 0.001239539 | 0.0334327 |
| 152 | LTBP3_1 | 11_65543062_T_C | 0.00124246 | 0.027887632 |
| 153 | BAG3_1 | 10_119651803_A_C | 0.001254787 | 0.031179453 |
| 154 | ANKRD2_1 | 10_97572685_T_G | 0.001261251 | 0.014732168 |
| 155 | ZNF451_1 | 6_57147971_C_A | 0.001263762 | 0.000340137 |
| 156 | ME2_1 | 18_50920583_C_T | 0.00130336 | 2.53E-06 |
| 157 | DLG5_1 | 10_77811963_T_G | 0.001305738 | 0.016910687 |
| 158 | USP19_1 | 3_49111457_T_C | 0.001383111 | 0.008511689 |
| 159 | PDCD11_1 | 10_103433899_A_G | 0.001419074 | 0.023046171 |
| 160 | PDE1B_1 | 12_54577030_T_G | 0.0014774 | 0.000907902 |
| 161 | LONP1_1 | 19_5707040_C_G | 0.001478061 | 0.014919269 |
| 162 | KCNN3_1 | 1_154733143_A_C | 0.001483801 | 0.012755172 |
| 163 | FSD1_1 | 19_4304543_G_C | 0.001495716 | 0.036857163 |
| 164 | F2RL1_1 | 5_76832874_T_G | 0.001535054 | 0.000269192 |
| 165 | XPO4_1 | 13_20787374_T_C | 0.001546207 | 0.044182604 |
| 166 | TM4SF1_1 | 3_149375342_T_G | 0.001551483 | 0.005766355 |
| 167 | NPAS1_1 | 19_47035965_T_G | 0.001567313 | 0.037858765 |
| 168 | FAM78A_1 | 9_131260861_G_A | 0.001574494 | 0.029873205 |
| 169 | SYTL2_1 | 11_85734802_A_C | 0.001576085 | 0.007792297 |
| 170 | TMEM57_1 | 1_25431052_T_G | 0.001577095 | 0.001041181 |
| 171 | TUBA1A_1 | 12_49186397_T_C | 0.001584541 | 0.019746043 |
| 172 | ITPR3_1 | 6_33692820_C_T | 0.001625448 | 0.001333145 |
| 173 | ATM_1 | 11_108317650_T_C | 0.001633198 | 0.007926126 |
| 174 | SGTA_1 | 19_2769109_A_C | 0.001653712 | 0.041785185 |
| 175 | LCORL_1 | 4_17883673_A_AAC | 0.001662772 | 0.000314326 |
| 176 | MTDH_1 | 8_97660911_G_GATA | 0.001694886 | 0.048360283 |
| 177 | IKBKB_1 | 8_42320656_T_C | 0.00170984 | 2.52E-05 |
| 178 | HNRNPD_1 | 4_82355277_C_CA | 0.001737277 | 0.049911299 |
| 179 | RAX_1 | 18_59272671_A_C | 0.001739655 | 0.028250861 |
| 180 | ZNF775_1 | 7_150397902_A_C | 0.001751147 | 0.01910485 |
| 181 | ALDH1A3_1 | 15_100885169_T_G | 0.001758148 | 0.04003907 |
| 182 | GNAI2_1 | 3_50252193_A_C | 0.001785905 | 0.005183043 |
| 183 | ZNF740_1 | 12_53187645_C_G | 0.001788461 | 0.049202233 |
| 184 | NTM_1 | 11_132307846_G_T | 0.001796239 | 0.000193861 |
| 185 | CHN1_1 | 2_174801578_A_G | 0.001797358 | 0.038050415 |
| 186 | PAX5_1 | 9_36923611_G_A | 0.001934236 | 0.014759026 |
| 187 | VAMP3_1 | 1_7781489_A_C | 0.00200626 | 0.040313352 |
| 188 | STK4_1 | 20_44995009_C_T | 0.002049488 | 5.24E-05 |
| 189 | USP24_1 | 1_55075675_C_A | 0.002073268 | 0.008980628 |
| 190 | EXOSC10_1 | 1_11080567_C_A | 0.002083377 | 0.019692529 |
| 191 | TINAGL1_1 | 1_31585380_T_G | 0.002085646 | 0.037138102 |
| 192 | SPTLC3_1 | 20_13093456_G_T | 0.002145546 | 0.024467108 |
| 193 | PLEKHA6_1 | 1_204257921_A_C | 0.002162143 | 0.049362899 |
| 194 | PLXNC1_1 | 12_94219931_T_G | 0.002163508 | 0.043558201 |
| 195 | CAPN2_1 | 1_223717830_G_A | 0.0022465 | 0.020893773 |
| 196 | TJP1_1 | 15_29718124_TA_T | 0.002277416 | 0.026903818 |
| 197 | ASPHD2_1 | 22_26442326_G_A | 0.002296851 | 0.029916144 |
| 198 | IFT43_1 | 14_76082206_T_G | 0.002305612 | 0.012552105 |
| 199 | CASK_1 | X_41578463_T_G | 0.002309184 | 0.043343775 |
| 200 | C21orf33_1 | 21_44144829_C_T | 0.002316139 | 0.047114252 |
| 201 | AFAP1L2_1 | 10_114294856_CCTAA_C | 0.00232372 | 0.037962739 |
| 202 | MEI1_1 | 22_41699656_A_C | 0.002354824 | 0.019192604 |
| 203 | HAUS6_1 | 9_19080551_G_A | 0.002357763 | 0.027262757 |
| 204 | LRRC8E_1 | 19_7899842_G_A | 0.002381607 | 0.011668019 |
| 205 | SMARCB1_1 | 22_23787366_GGC_G | 0.002396307 | 0.000127894 |
| 206 | DUT_1 | 15_48332272_A_C | 0.002405318 | 0.00018263 |
| 207 | MON1A_1 | 3_49911902_A_G | 0.002439566 | 0.010543368 |
| 208 | SASH1_1 | 6_148440274_CT_C | 0.002448515 | 0.046157021 |
| 209 | MAP1S_1 | 19_17726640_A_C | 0.002527497 | 0.022464441 |
| 210 | TOE1_1 | 1_45340381_G_A | 0.002528538 | 0.048016234 |
| 211 | CNOT7_1 | 8_17242848_C_T | 0.002530932 | 7.40E-11 |
| 212 | CD244_1 | 1_160836124_G_A | 0.002583957 | 0.026316972 |
| 213 | EPM2AIP1_1 | 3_36992730_A_C | 0.002610713 | 0.00113706 |
| 214 | PRSS16_1 | 6_27249457_C_T | 0.002649855 | 0.041003068 |
| 215 | GPSM3_1 | 6_32192179_T_C | 0.002655487 | 0.017253689 |
| 216 | UGDH_1 | 4_39527132_G_A | 0.002672816 | 0.035973223 |
| 217 | AIG1_1 | 6_143060973_T_C | 0.002697343 | 0.001184612 |
| 218 | PMS1_1 | 2_189864380_G_A | 0.002709035 | 0.028805775 |
| 219 | PTGFR_1 | 1_78497752_G_A | 0.002814073 | 0.008690688 |
| 220 | AGPAT2_1 | 9_136674614_A_G | 0.002858165 | 0.022967509 |
| 221 | CBL_1 | 11_119278299_T_G | 0.002995636 | 0.015544213 |
| 222 | RAB37_1 | 17_74694690_G_A | 0.003050869 | 0.017656336 |
| 223 | GTPBP3_1 | 19_17338111_A_C | 0.003059974 | 0.000709713 |
| 224 | HDAC4_1 | 2_239053232_A_C | 0.003067942 | 0.036469606 |
| 225 | MBD3_1 | 19_1577118_C_T | 0.003069952 | 0.001822739 |
| 226 | CEP170_1 | 1_243164906_G_A | 0.003157617 | 0.005533907 |
| 227 | S100A16_1 | 1_153607964_A_G | 0.003160582 | 0.026054854 |
| 228 | DCK_1 | 4_71022615_CT_C | 0.003222902 | 0.021365647 |
| 229 | INF2_1 | 14_104713013_A_C | 0.003224544 | 0.022440089 |
| 230 | MYO6_1 | 6_75870526_T_C | 0.003249199 | 0.022167818 |
| 231 | CDS1_1 | 4_84635369_T_A | 0.003299427 | 0.032630939 |
| 232 | CTDSPL_1 | 3_37980672_C_T | 0.003333659 | 0.043268165 |
| 233 | EPB41L1_1 | 20_36187855_G_T | 0.003410098 | 0.042407864 |
| 234 | FGR_1 | 1_27617489_T_A | 0.003443717 | 0.014581374 |
| 235 | CAPRIN1_1 | 11_34051813_A_G | 0.003553009 | 0.001206062 |
| 236 | FOXC1_1 | 6_1612184_TA_T | 0.00358795 | 0.004712911 |
| 237 | ARHGEF6_1 | X_136685627_G_A | 0.003598733 | 0.001837929 |
| 238 | BCAR3_1 | 1_93674923_G_C | 0.003606528 | 0.049870881 |
| 239 | BCL9L_1 | 11_118897861_A_C | 0.003681075 | 0.034238861 |
| 240 | TMEM201_1 | 1_9610425_T_A | 0.003707837 | 0.025977963 |
| 241 | RPS11_1 | 19_49496985_C_T | 0.003720736 | 0.048243831 |
| 242 | GMEB1_1 | 1_28690201_G_T | 0.003734863 | 0.005247117 |
| 243 | XRCC5_1 | 2_216109182_G_C | 0.00380529 | 0.019360584 |
| 244 | IL13RA1_1 | X_118776541_G_T | 0.003874528 | 0.009303333 |
| 245 | PRR14_1 | 16_30651924_T_G | 0.003882844 | 0.041861928 |
| 246 | SH2B3_1 | 12_111418260_C_G | 0.003991404 | 0.00753988 |
| 247 | DTNBP1_1 | 6_15662698_A_G | 0.00400197 | 0.006306033 |
| 248 | PADI1_1 | 1_17228910_T_G | 0.004006843 | 0.013302935 |
| 249 | FAF1_1 | 1_50787989_A_G | 0.004030148 | 0.030848308 |
| 250 | RAB11FIP5_1 | 2_73075763_G_GGCCT | 0.004085081 | 0.024778824 |
| 251 | ZBTB40_1 | 1_22508509_T_G | 0.004115308 | 0.00741291 |
| 252 | BLCAP_1 | 20_37517746_T_C | 0.004121218 | 0.011965638 |
| 253 | KIF2A_1 | 5_62373627_T_G | 0.004150384 | 0.036674489 |
| 254 | HCFC1_1 | X_153963207_T_G | 0.004154957 | 0.001579155 |
| 255 | HINFP_1 | 11_119121467_T_C | 0.004250524 | 0.04539997 |
| 256 | PRDM2_1 | 1_13823349_T_A | 0.004303676 | 0.011003429 |
| 257 | EIF4E_1 | 4_98902074_AT_A | 0.004333629 | 0.008214508 |
| 258 | PARVG_1 | 22_44206294_C_G | 0.004424 | 0.028583204 |
| 259 | COX18_1 | 4_73064835_G_A | 0.004489575 | 0.009081073 |
| 260 | WDR33_1 | 2_127701640_C_G | 0.004497758 | 0.006721664 |
| 261 | ARHGAP9_1 | 12_57474460_G_A | 0.004523019 | 0.041357487 |
| 262 | GGCX_1 | 2_85550432_A_G | 0.004614743 | 0.015128917 |
| 263 | ZNF182_1 | X_47983350_T_G | 0.004661316 | 0.045101518 |
| 264 | ANXA6_1 | 5_151117292_C_T | 0.004727288 | 0.038173193 |
| 265 | RPL14_1 | 3_40457950_G_A | 0.004955666 | 0.001218496 |
| 266 | FCHO2_1 | 5_73082876_ATT_A | 0.004962427 | 0.029256929 |
| 267 | RAB28_1 | 4_13473790_TATC_T | 0.004968595 | 0.040901005 |
| 268 | RNGTT_1 | 6_88769645_C_T | 0.00502562 | 0.002545266 |
| 269 | NNT_1 | 5_43602611_T_C | 0.005081886 | 0.030151517 |
| 270 | CLDN1_1 | 3_190308594_C_T | 0.005105908 | 0.019956392 |
| 271 | NRN1_1 | 6_6003752_C_T | 0.005133833 | 0.006175355 |
| 272 | ZNF423_1 | 16_49635837_A_C | 0.005155281 | 0.015077717 |
| 273 | YES1_1 | 18_732727_A_G | 0.00519113 | 0.026256279 |
| 274 | RAPGEF6_1 | 5_131433731_GA_G | 0.005213959 | 0.0053626 |
| 275 | MGAT4B_1 | 5_179799918_A_G | 0.005262946 | 0.044186289 |
| 276 | GATAD2B_1 | 1_153818250_T_C | 0.005279052 | 0.026743921 |
| 277 | FCRL5_1 | 1_157518564_T_C | 0.005397526 | 0.023539142 |
| 278 | ACSS2_1 | 20_34925819_A_C | 0.00560253 | 0.016776881 |
| 279 | CTR9_1 | 11_10773884_CAAAAA_C | 0.005625384 | 0.03664895 |
| 280 | INPP5B_1 | 1_37872885_G_T | 0.005738649 | 0.010365859 |
| 281 | RPAIN_1 | 17_5421266_TTC_T | 0.005740177 | 0.041469888 |
| 282 | RCHY1_1 | 4_75509142_T_A | 0.00575286 | 7.00E-06 |
| 283 | RASSF7_1 | 11_562335_A_C | 0.005935904 | 0.018138357 |
| 284 | NKX3-2_1 | 4_13541263_A_G | 0.00596504 | 0.000419444 |
| 285 | IGFBP3_1 | 7_45917562_GT_G | 0.006141827 | 0.045400401 |
| 286 | LTBR_1 | 12_6385217_T_C | 0.006192879 | 9.81E-05 |
| 287 | GNG2_1 | 14_51950694_A_C | 0.006226032 | 0.02637487 |
| 288 | NAP1L1_1 | 12_76084896_T_C | 0.006264126 | 0.018182577 |
| 289 | GULP1_1 | 2_188589974_C_CT | 0.006362476 | 0.004507263 |
| 290 | PXDC1_1 | 6_3727577_C_G | 0.006364895 | 0.027367829 |
| 291 | WDR12_1 | 2_202897546_T_A | 0.006402216 | 0.044170968 |
| 292 | TMBIM6_1 | 12_49742405_G_A | 0.006435087 | 0.019471463 |
| 293 | PPM1D_1 | 17_60656452_CA_C | 0.006580355 | 0.01692061 |
| 294 | RPA2_1 | 1_27907061_GA_G | 0.006586873 | 0.02798096 |
| 295 | PRR3_1 | 6_30562126_T_G | 0.006592704 | 0.005676599 |
| 296 | RBM28_1 | 7_128310614_C_A | 0.006924451 | 0.019795754 |
| 297 | ENAH_1 | 1_225519569_GAAAA_G | 0.007036997 | 0.048924277 |
| 298 | KIAA0922_1 | 4_153592379_A_G | 0.0070597 | 0.048688528 |
| 299 | TRIM2_1 | 4_153276097_A_G | 0.007183471 | 0.011894098 |
| 300 | ATP8B1_1 | 18_57731374_T_C | 0.007320467 | 0.035819404 |
| 301 | QSOX1_1 | 1_180178802_A_G | 0.007420273 | 0.008203943 |
| 302 | MB_1 | 22_35607296_C_G | 0.007592955 | 0.045421658 |
| 303 | ORAI2_1 | 7_102433548_G_A | 0.007786599 | 0.035889292 |
| 304 | WNT7B_1 | 22_45931386_G_A | 0.007831858 | 0.025701725 |
| 305 | PIKFYVE_1 | 2_208330748_GT_G | 0.007852983 | 0.009816454 |
| 306 | ARHGAP32_1 | 11_128972609_T_G | 0.007895267 | 0.007875634 |
| 307 | SH3YL1_1 | 2_249571_C_T | 0.007939764 | 0.043096755 |
| 308 | DEPDC5_1 | 22_31843912_CT_C | 0.00801665 | 0.025230811 |
| 309 | VSIG10_1 | 12_118073908_T_G | 0.008024404 | 0.001976122 |
| 310 | SLX4_1 | 16_3595722_A_C | 0.008031231 | 0.013087513 |
| 311 | REEP3_1 | 10_63621980_A_G | 0.008035335 | 0.03021965 |
| 312 | FARSB_1 | 2_222571709_T_C | 0.00812224 | 0.037339824 |
| 313 | NDUFS3_1 | 11_47578800_A_G | 0.00843631 | 0.008511324 |
| 314 | HIBADH_1 | 7_27538786_G_A | 0.008437431 | 0.025866827 |
| 315 | SCLT1_1 | 4_128957191_A_C | 0.008485976 | 0.015508556 |
| 316 | SLC20A2_1 | 8_42439475_C_T | 0.008560526 | 0.001296999 |
| 317 | LMO7_1 | 13_75855483_C_A | 0.008616687 | 0.000790188 |
| 318 | SREBF2_1 | 22_41897136_G_C | 0.008665061 | 0.031235978 |
| 319 | SPAG1_1 | 8_100194395_C_A | 0.008766072 | 0.025833604 |
| 320 | NCAM1_1 | 11_113270137_A_G | 0.008796809 | 0.040540565 |
| 321 | ATP1B1_1 | 1_169111407_C_G | 0.008822814 | 0.015890801 |
| 322 | PLXNB2_1 | 22_50281752_C_G | 0.008850507 | 0.048268974 |
| 323 | PFAS_1 | 17_8269414_A_G | 0.008856682 | 0.026137416 |
| 324 | CEP152_1 | 15_48762574_G_C | 0.008866418 | 0.044026406 |
| 325 | GNRH1_1 | 8_25423267_A_G | 0.009056061 | 0.039449902 |
| 326 | CARD10_1 | 22_37508612_T_C | 0.009110799 | 0.021324272 |
| 327 | COL6A3_1 | 2_237351090_T_G | 0.00914922 | 0.009459532 |
| 328 | RBM12B_1 | 8_93733158_G_T | 0.009183374 | 0.012443278 |
| 329 | ITPKC_1 | 19_40737666_A_C | 0.009205546 | 0.045257656 |
| 330 | ARHGAP31_1 | 3_119390922_C_T | 0.009221747 | 0.042725387 |
| 331 | GRAMD1A_1 | 19_35022992_C_T | 0.00930255 | 0.030347265 |
| 332 | SAE1_1 | 19_47131056_T_G | 0.009443122 | 0.006083296 |
| 333 | MICALL1_1 | 22_37924607_T_G | 0.009460572 | 0.025017274 |
| 334 | GABRB2_1 | 5_161336809_G_A | 0.009484795 | 0.019276169 |
| 335 | SPINT2_1 | 19_38287977_A_G | 0.009500965 | 0.018521267 |
| 336 | ATXN7_1 | 3_63990247_A_C | 0.009623217 | 5.97E-05 |
| 337 | TATDN2_1 | 3_10248824_C_CT | 0.009659313 | 0.000116552 |
| 338 | AP4E1_1 | 15_50968319_T_G | 0.009752147 | 0.046599506 |
| 339 | CHST2_1 | 3_143121243_A_G | 0.009892538 | 0.040099833 |
| 340 | PRKAG2_1 | 7_151560579_A_G | 0.009896448 | 0.024618763 |
| 341 | C16orf45_1 | 16_15596596_T_G | 0.009927037 | 0.04351851 |
| 342 | SULT2B1_1 | 19_48591514_T_G | 0.009943382 | 0.006727275 |
| 343 | DSTN_1 | 20_17600864_A_G | 0.009947784 | 0.000427203 |
| 344 | TPD52L2_1 | 20_63889961_A_C | 0.010191021 | 0.005896198 |
| 345 | E2F2_1 | 1_23521217_C_G | 0.010495212 | 0.008957912 |
| 346 | TSEN34_1 | 19_54192354_T_G | 0.010854598 | 0.001848481 |
| 347 | FOXN3_1 | 14_89162512_A_C | 0.011014558 | 0.001249668 |
| 348 | MND1_1 | 4_153408912_G_GTATATA | 0.011263008 | 0.006400349 |
| 349 | ZDHHC5_1 | 11_57696028_T_C | 0.01129582 | 0.000204877 |
| 350 | ARMCX4_1 | X_101488321_C_G | 0.011422104 | 0.008157752 |
| 351 | P2RY11_1 | 19_10115376_G_A | 0.011466091 | 0.000105991 |
| 352 | C1orf198_1 | 1_230839028_T_C | 0.011890625 | 0.008759206 |
| 353 | TPTE2_1 | 13_19425773_G_A | 0.011929579 | 0.00812417 |
| 354 | TMEM206_1 | 1_212379769_G_C | 0.01195192 | 0.000739419 |
| 355 | REEP5_1 | 5_112891583_T_A | 0.012573055 | 0.001996089 |
| 356 | CNNM4_1 | 2_96798981_T_G | 0.012933399 | 0.000393837 |
| 357 | GPR65_1 | 14_88011069_C_T | 0.013002947 | 0.005376071 |
| 358 | ZDHHC7_1 | 16_84981848_T_G | 0.013133304 | 0.007398316 |
| 359 | KCNAB3_1 | 17_7925552_G_A | 0.013376003 | 0.008474756 |
| 360 | ASNSD1_1 | 2_189670812_C_T | 0.013663903 | 0.004106264 |
| 361 | LY9_1 | 1_160814485_A_C | 0.014209114 | 0.004017681 |
| 362 | SKIV2L2_1 | 5_55307994_T_C | 0.01489715 | 0.008290134 |
| 363 | MADD_1 | 11_47325027_T_C | 0.01504914 | 0.001497343 |
| 364 | ITPRIPL1_1 | 2_96325641_T_G | 0.0151793 | 0.004828474 |
| 365 | SDC4_1 | 20_45330303_T_G | 0.015973482 | 0.000496261 |
| 366 | SLC2A8_1 | 9_127398490_G_A | 0.016168742 | 0.003968261 |
| 367 | CSF2RB_1 | 22_36923285_A_C | 0.016450302 | 0.008060727 |
| 368 | WWTR1_1 | 3_149669685_C_T | 0.016674011 | 0.040303211 |
| 369 | PEX10_1 | 1_2410431_A_C | 0.017756279 | 7.19E-05 |
| 370 | SCMH1_1 | 1_41033845_T_G | 0.01786284 | 0.006455807 |
| 371 | WNT10A_1 | 2_218882471_A_C | 0.018148757 | 0.008633339 |
| 372 | SIRT4_1 | 12_120303510_G_GAA | 0.018478224 | 0.002426212 |
| 373 | SLC25A43_1 | X_119451980_A_G | 0.018546868 | 0.000927303 |
| 374 | SLC35F5_1 | 2_113723196_TA_T | 0.019332514 | 0.009792442 |
| 375 | PLEKHA5_1 | 12_19369550_A_AAAAG | 0.019740309 | 0.004535622 |
| 376 | RASEF_1 | 9_82982805_CAGAG_C | 0.019798987 | 5.81E-06 |
| 377 | RASSF2_1 | 20_4797919_T_G | 0.019937429 | 0.007153311 |
| 378 | ANKRD44_1 | 2_197099965_G_A | 0.020081182 | 0.009634061 |
| 379 | ZFYVE19_1 | 15_40812591_A_AAG | 0.020142634 | 0.000177529 |
| 380 | TMEM2_1 | 9_71704688_T_G | 0.02064031 | 0.00528138 |
| 381 | TMEM159_1 | 16_21174063_G_A | 0.020994925 | 0.001734513 |
| 382 | PEX13_1 | 2_61045783_A_T | 0.021004523 | 0.005293964 |
| 383 | BCAR1_1 | 16_75229126_T_A | 0.021029307 | 0.004775721 |
| 384 | SLC25A38_1 | 3_39389590_G_A | 0.021402491 | 5.21E-05 |
| 385 | ING5_1 | 2_241711916_A_C | 0.021779734 | 0.000297693 |
| 386 | AHR_1 | 7_17339074_A_C | 0.021825994 | 0.009928124 |
| 387 | ETV1_1 | 7_13900838_A_C | 0.022234699 | 0.00028392 |
| 388 | FUS_1 | 16_31191353_T_G | 0.022580325 | 0.000527105 |
| 389 | ELMO1_1 | 7_36986095_A_C | 0.022675843 | 0.000582138 |
| 390 | FLI1_1 | 11_128772826_T_G | 0.022696029 | 2.10E-08 |
| 391 | RBPJ_1 | 4_26321137_C_A | 0.023026755 | 0.005948758 |
| 392 | TGM1_1 | 14_24260894_A_C | 0.023877255 | 4.06E-05 |
| 393 | MAD2L2_1 | 1_11680485_C_A | 0.024343193 | 0.005401081 |
| 394 | CCDC66_1 | 3_56613771_T_C | 0.024734355 | 0.00694013 |
| 395 | E2F3_1 | 6_20402547_A_C | 0.024779926 | 0.001096854 |
| 396 | TRIM47_1 | 17_75875198_A_C | 0.025043777 | 0.006990418 |
| 397 | LACTB2_1 | 8_70657773_A_C | 0.025193805 | 0.000265188 |
| 398 | S100A13_1 | 1_153619154_A_C | 0.026872567 | 0.000285894 |
| 399 | PRKCZ_1 | 1_2059508_T_G | 0.027355157 | 0.000553783 |
| 400 | KIAA0430_1 | 16_15601202_A_G | 0.027767771 | 0.008344755 |
| 401 | PARP1_1 | 1_226377365_T_C | 0.028078591 | 0.000660394 |
| 402 | VMP1_1 | 17_59841357_A_C | 0.028144116 | 0.00700708 |
| 403 | TRPM7_1 | 15_50619668_AT_A | 0.028234282 | 0.007696192 |
| 404 | RPL11_1 | 1_23695353_C_A | 0.028842665 | 0.006999268 |
| 405 | RHPN2_1 | 19_33002924_G_A | 0.02894401 | 0.001694408 |
| 406 | MAST3_1 | 19_18107675_A_T | 0.028979003 | 0.002887665 |
| 407 | SACS_1 | 13_23354711_A_C | 0.029483838 | 0.007436264 |
| 408 | ZBTB4_1 | 17_7463332_C_G | 0.030579241 | 0.009123992 |
| 409 | SSH3_1 | 11_67309455_A_C | 0.031167208 | 0.006068708 |
| 410 | STAU1_1 | 20_49153934_T_C | 0.031695969 | 0.047157357 |
| 411 | PRSS22_1 | 16_2853046_G_C | 0.032478102 | 0.003660773 |
| 412 | SRRD_1 | 22_26488073_G_A | 0.03313164 | 0.001986837 |
| 413 | ITGB8_1 | 7_20399120_C_G | 0.033295835 | 0.000193939 |
| 414 | FLII_1 | 17_18245630_C_G | 0.033989678 | 0.00994433 |
| 415 | TMEM40_1 | 3_12769284_C_T | 0.034416268 | 0.003842868 |
| 416 | SLC19A1_1 | 21_45512453_A_C | 0.034642487 | 0.009916208 |
| 417 | FBN1_1 | 15_48425289_G_T | 0.035154355 | 0.007224526 |
| 418 | TMC4_1 | 19_54160564_G_A | 0.03557474 | 0.008695606 |
| 419 | TACC2_1 | 10_122132454_G_A | 0.036645036 | 7.09E-05 |
| 420 | HEATR5A_1 | 14_31315848_T_C | 0.037815962 | 0.000583004 |
| 421 | SLC25A24_1 | 1_108161212_C_T | 0.038139179 | 0.001625377 |
| 422 | TMEM39B_1 | 1_32091713_A_C | 0.038513492 | 0.008701631 |
| 423 | ANKRD22_1 | 10_88831974_A_C | 0.039475145 | 0.00796284 |
| 424 | SFSWAP_1 | 12_131753058_C_G | 0.039748632 | 0.004289964 |
| 425 | C1orf54_1 | 1_150279750_G_C | 0.039956255 | 0.001281485 |
| 426 | SEPT10_1 | 2_109564377_G_T | 0.040053757 | 0.00487648 |
| 427 | FOS_1 | 14_75280999_A_C | 0.04011469 | 0.001488063 |
| 428 | AARS2_1 | 6_44301927_CAGG_C | 0.041166243 | 0.004966986 |
| 429 | EMP1_1 | 12_13211531_T_G | 0.041461108 | 0.001600571 |
| 430 | FBXO2_1 | 1_11648995_C_G | 0.042445462 | 0.005932397 |
| 431 | UBE3A_1 | 15_25408653_C_A | 0.044428109 | 0.002080316 |
| 432 | GPC1_1 | 2_240451007_T_G | 0.044965723 | 0.007919222 |
| 433 | ACTN4_1 | 19_38728028_T_G | 0.045229843 | 0.005408687 |
| 434 | EPB41L4B_1 | 9_109182980_T_C | 0.045378555 | 0.002429073 |
| 435 | SERTAD3_1 | 19_40441466_GGATC_G | 0.045415799 | 0.001465832 |
| 436 | WHSC1L1_1 | 8_38315857_G_C | 0.046096872 | 0.004506209 |
| 437 | QRICH1_1 | 3_49076524_TAAA_T | 0.046339149 | 0.007356338 |
| 438 | CAMSAP3_1 | 19_7618018_A_C | 0.046801001 | 0.000416732 |
| 439 | TCHP_1 | 12_109907472_T_G | 0.047094137 | 0.003720466 |
| 440 | TUFT1_1 | 1_151565936_G_A | 0.048675231 | 0.004559558 |
| 441 | CHMP1A_1 | 16_89649256_C_T | 0.048695701 | 0.003804631 |
| 442 | LAMB2_1 | 3_49125146_T_G | 0.049754671 | 0.002569959 |
| 443 | PNRC2_1 | 1_23961290_GCTT_G | 0.049756672 | 0.006024417 |
| 444 | MARVELD2_1 | 5_69419733_A_C | 0.049786079 | 0.007668831 |
| 445 | SLC22A18_3 | 11_2919250_T_G / 11_2903361_G_A / 11_2919268_T_G | 0.00010006113410040524 / 0.0011537278855378685 / 0.03948380156101269 | 0.003253241739951185 / 0.009485355002003664 / 0.004588734004408302 |
| 446 | SH3D19_3 | 4_151148254_TACACACACACACACAC_T / 4_151122202_T_C / 4_151148202_G_T | 0.00010065962678441032 / 0.015768562077467373 / 0.0009087951468125592 | 0.016052772944150497 / 0.00026537095134489047 / 0.004030165987762314 |
| 447 | LARS2_5 | 3_45474156_T_C / 3_45476267_G_A / 3_45488909_G_A / 3_45500591_T_C / 3_45417241_A_G | 0.00010374784857743111 / 3.7424426310272928e-06 / 1.2434210249182578e-07 / 6.432927229497336e-08 / 0.004689576487598519 | 1.1453239774161183e-13 / 9.671821420877082e-13 / 6.257680298053254e-14 / 4.345853387032865e-14 / 0.022164736928693304 |
| 448 | SRGAP1_2 | 12_64142411_T_C / 12_64097222_GTT_G | 0.00010959539878441124 / 0.0011886231256692465 | 0.006505852651723906 / 0.02613509690642953 |
| 449 | ALDH3A1_3 | 17_19742310_G_A / 17_19748298_C_T / 17_19740913_C_G | 0.00011241479007533596 / 0.0023838380538555946 / 0.026511359318080838 | 0.016065461057378518 / 0.04852415829065191 / 0.0007153928676742558 |
| 450 | LPIN3_5 | 20_41345676_A_G / 20_41358461_T_G / 20_41358465_C_G / 20_41340873_C_A / 20_41350009_T_G | 0.00011710984250539265 / 0.000846270947552816 / 0.0063262440202536815 / 7.192100726008128e-05 / 0.033798727519866234 | 0.001902884670314011 / 5.712471333190794e-05 / 6.891802498643105e-05 / 0.025739865299148755 / 0.0036707505113827256 |
| 451 | LAMB3_3 | 1_209626885_C_T / 1_209626996_C_T / 1_209630438_C_T | 0.00012286163323842149 / 0.0001560650413956853 / 0.00010264198687506551 | 0.014463355479842403 / 0.005725629984184445 / 0.0254414675884508 |
| 452 | RAC1_2 | 7_6398689_A_C / 7_6401802_T_G | 0.00012312607987750062 / 0.022378677686989437 | 0.0005959472772163739 / 0.003141262984465143 |
| 453 | CERKL_2 | 2_181603835_A_C / 2_181678048_T_G | 0.00012332912254087272 / 0.00048702996607960313 | 8.976196985876391e-05 / 0.010552400468127526 |
| 454 | MTO1_2 | 6_73492090_C_T / 6_73473277_C_CAGAT | 0.0001242869571724915 / 0.027975699490295474 | 0.0009500421967262693 / 0.0034299441619718607 |
| 455 | SUMF1_2 | 3_4419885_G_A / 3_3846683_A_C | 0.00013129129316308624 / 0.007888292383663753 | 0.017506933739797337 / 0.0026519652256760252 |
| 456 | WDFY4_5 | 10_48946696_T_C / 10_48774557_A_C / 10_48823427_C_T / 10_48826590_T_A / 10_48709976_C_T | 0.00014298234740370438 / 7.877438075749654e-06 / 0.006750199117687904 / 0.008731995024502738 / 0.0057882693531272345 | 0.03553981554074815 / 0.02592605078891659 / 0.041159506689191376 / 0.03934434383747865 / 0.036092320181802036 |
| 457 | DSC2_3 | 18_31091249_T_G / 18_31093490_T_G / 18_31080273_C_T | 0.00014328639925920681 / 0.026176748525728964 / 0.004444668756137834 | 0.002053875263128439 / 3.7895626071773765e-05 / 1.9855794171946574e-05 |
| 458 | MBD1_4 | 18_50276088_C_A / 18_50276601_A_G / 18_50275492_T_G / 18_50275430_G_A | 0.00014793743904567252 / 0.01877342572270696 / 0.003092273916220477 / 0.0033406482616730533 | 0.002775832151787685 / 0.0007205116796968372 / 0.027183042271681262 / 0.047488972926164726 |
| 459 | KIAA1671_2 | 22_25029373_T_C / 22_25170874_A_C | 0.00015698694769979702 / 0.0006020288880688977 | 0.04147687852552058 / 0.03878706897291035 |
| 460 | MET_3 | 7_116740945_T_G / 7_116757685_T_G / 7_116740947_C_G | 0.00016797515698396606 / 0.002832945772163542 / 0.002231117554658809 | 0.00017295700570667475 / 5.0554093231126755e-05 / 0.0012218666498089645 |
| 461 | RCBTB1_2 | 13_49585356_T_A / 13_49533768_G_A | 0.0001756869709333519 / 0.009455073314037034 | 0.02533885676009956 / 0.019692263494698818 |
| 462 | PPL_4 | 16_4883459_A_G / 16_4894423_G_C / 16_4901058_T_G / 16_4891747_T_G | 0.0001758787943382569 / 0.0007098905861696843 / 0.0005647077594982514 / 0.011689794335935037 | 0.009286392985327631 / 0.04550405331166151 / 0.01682150071796396 / 0.0032410422551606864 |
| 463 | TMEM63A_3 | 1_225856800_GC_G / 1_225856891_C_T / 1_225845173_C_T | 0.00017631469170194104 / 0.0005047149993335916 / 1.5371108451049484e-05 | 0.04262290781357216 / 0.031894233309554584 / 0.039853481810337744 |
| 464 | KDM4B_5 | 19_5110783_A_G / 19_5047680_G_A / 19_5111856_C_T / 19_5152376_T_C / 19_5114105_T_G | 0.00018149502531503815 / 0.0011449297013059851 / 3.0255655048228253e-05 / 0.0056532335440754155 / 0.005029743152006167 | 0.0038743952075057523 / 0.0010649511420676163 / 0.008640482718151363 / 0.012419815562589162 / 0.0315424322762135 |
| 465 | TAF4B_2 | 18_26286027_C_A / 18_26293570_AT_A | 0.0001933876544072626 / 0.0006065453361074753 | 0.005234163638807017 / 0.02416136973363145 |
| 466 | MAP2K7_3 | 19_7905750_A_G / 19_7911231_T_C / 19_7910579_A_C | 0.00020437876506728577 / 5.172101478935253e-05 / 6.985639899444967e-05 | 0.026466975715454883 / 0.014436739312155004 / 0.014559538606612087 |
| 467 | EGFR_5 | 7_55160480_C_T / 7_55170771_T_G / 7_55205133_G_A / 7_55181370_G_A / 7_55205662_A_C | 0.00020841604787297526 / 0.00045465182013688124 / 0.02209047666362801 / 0.00015707737069901731 / 0.0019734565993096485 | 0.042584839287283 / 0.004588325394927623 / 0.003745674667154008 / 0.030349772078527886 / 0.0007797573368817686 |
| 468 | MED4_2 | 13_48079728_CAAA_C / 13_48077399_A_AT | 0.00021592440051490123 / 0.00970359638804136 | 0.028274397927711425 / 0.04285821577494423 |
| 469 | PSMG1_2 | 21_39183425_G_C / 21_39175728_T_C | 0.00022608775731841645 / 0.012584465994979182 | 0.00513068025831651 / 0.006708397725563725 |
| 470 | SYMPK_3 | 19_45823908_G_A / 19_45835234_G_A / 19_45842628_T_C | 0.0002277738548719044 / 7.560389488032653e-05 / 0.007665716537369837 | 0.03948007686982654 / 0.026714512477614062 / 0.0420060391850977 |
| 471 | CNKSR1_6 | 1_26180299_A_G / 1_26181802_G_A / 1_26181989_T_C / 1_26183270_A_C / 1_26184255_A_C / 1_26180691_T_G | 0.00022855371657961118 / 0.000553633072814145 / 0.004976293349453925 / 0.0012311577321858017 / 0.00011380023959208459 / 2.366839986118124e-05 | 0.0031268776228605263 / 0.042309660108738684 / 0.031585176815995236 / 0.007340521806393782 / 0.03620130672603948 / 0.0014019419704167026 |
| 472 | LGR4_3 | 11_27373900_C_T / 11_27380156_G_A / 11_27368981_G_A | 0.00022889582425503487 / 0.00022889582425503487 / 7.68908468665983e-05 | 0.02925705779271898 / 0.02925705779271898 / 0.007261247877037425 |
| 473 | VTCN1_3 | 1_117157003_C_T / 1_117172345_T_C / 1_117172578_ATTT_A | 0.0002510217205927707 / 8.944919469827468e-06 / 0.016016251707355836 | 0.03055768777478911 / 0.023227355162109414 / 0.001594504991034824 |
| 474 | CRBN_6 | 3_3151010_G_T / 3_3152273_A_C / 3_3154589_AT_A / 3_3175444_AT_A / 3_3179746_C_T / 3_3150840_A_ATAAC | 0.0002626503373527541 / 0.013274951670738794 / 7.062286693324899e-05 / 0.0004048382754165016 / 0.003012811333138018 / 3.124023410218089e-05 | 0.0018118056645904023 / 0.00018124433406194467 / 2.1732312542326866e-07 / 7.214198132928058e-05 / 1.1224125713318842e-06 / 3.115850854605648e-06 |
| 475 | SMCHD1_5 | 18_2707621_G_A / 18_2724932_A_T / 18_2763699_C_T / 18_2656105_T_G / 18_2795854_A_G | 0.00026503656166190905 / 0.009320150621080624 / 0.0042306245640629115 / 0.025865035105419227 / 0.0001080554536414254 | 7.290016375189198e-05 / 0.03677531412547839 / 0.02250972081801197 / 3.289863234127764e-05 / 0.037011899642268684 |
| 476 | HDAC11_2 | 3_13496579_C_G / 3_13496863_T_TG | 0.00027757125208069643 / 0.00015267586088891374 | 0.0271728892750038 / 0.0149184097594151 |
| 477 | PIK3CD_4 | 1_9720778_T_G / 1_9721354_C_G / 1_9722498_C_T / 1_9710297_C_T | 0.00030314689537509136 / 7.877458405180158e-05 / 2.4181398805762395e-05 / 0.002966501395718009 | 0.0012148539768169404 / 0.04037203630033394 / 0.011926248274336807 / 0.011351289482054416 |
| 478 | GCDH_3 | 19_12891586_G_C / 19_12891749_T_G / 19_12899706_A_G | 0.000306793254674835 / 0.0003686903209515677 / 0.009343822168831345 | 0.0326186066813529 / 0.03376530749875928 / 0.00026130883839357806 |
| 479 | SEC11C_2 | 18_59152698_T_C / 18_59158845_T_C | 0.00030911539588566946 / 0.00956493460787828 | 0.0022574597582570113 / 0.029955010760308976 |
| 480 | SAFB_2 | 19_5667193_AC_A / 19_5668433_GT_G | 0.0003098805881779707 / 0.044739771014985504 | 0.002063538258127222 / 0.0026106809691974946 |
| 481 | ATP6V1B2_3 | 8_20212278_G_C / 8_20218183_C_A / 8_20214681_A_G | 0.0003172005709671975 / 1.980177091110716e-06 / 7.277973285376886e-05 | 0.001539493748390498 / 0.02168738622123026 / 0.025450124159694176 |
| 482 | PUS3_4 | 11_125896149_C_A / 11_125896278_A_C / 11_125896309_G_C / 11_125896312_C_T | 0.00031902172789162014 / 0.0016768215144890312 / 0.00019026344698916655 / 0.0006367828673033801 | 0.02249427642441209 / 0.03343255062895107 / 0.0192679955094738 / 0.02546202950317841 |
| 483 | XDH_2 | 2_31383804_G_A / 2_31398732_T_C | 0.00033628525023115955 / 0.007506095065621764 | 0.04221528923752448 / 0.006330815240399064 |
| 484 | WDR7_4 | 18_56679573_T_G / 18_56781547_G_A / 18_56815915_A_G / 18_57027330_A_ACGGC | 0.00034150498667130327 / 3.859660027634848e-06 / 0.002362739963128272 / 0.006245785108127786 | 1.7583606026050092e-08 / 0.0071713352600959014 / 0.003286339206119661 / 0.04783850584421885 |
| 485 | GJB2_2 | 13_20189503_C_T / 13_20189241_T_C | 0.00035796332888395017 / 0.008815817126700895 | 0.005240901157790961 / 0.03930064243744275 |
| 486 | NFATC1_5 | 18_79486406_T_G / 18_79486978_G_A / 18_79449015_A_G / 18_79451175_T_C / 18_79467476_A_G | 0.0003603073768446487 / 5.049273733042917e-05 / 0.02785434119032008 / 0.02220634088861789 / 0.0002507020345223831 | 0.018612271205492262 / 0.026732897678207176 / 0.0006549922975230749 / 0.0005874163668026321 / 0.003817175702412812 |
| 487 | TMEM141_2 | 9_136791905_T_C / 9_136791680_A_G | 0.0004169452454367874 / 3.984588209897019e-05 | 0.03333885281311693 / 0.020229651998436324 |
| 488 | GON4L_3 | 1_155750010_A_G / 1_155813972_C_T / 1_155826993_A_G | 0.0004229050700030183 / 0.009903573910672052 / 0.002653632924091959 | 0.014960076537640884 / 0.0034455240142541605 / 0.03840390796922083 |
| 489 | THOC1_4 | 18_218753_C_A / 18_259800_G_GA / 18_264012_G_A / 18_260303_A_C | 0.00043864187590166915 / 3.026788938964173e-05 / 6.794818264684467e-06 / 0.0036079810571773866 | 0.01174777561883113 / 0.04550027828580569 / 0.038030003830584136 / 0.031572528408919984 |
| 490 | MOCOS_3 | 18_36268700_A_ATACAT / 18_36195408_G_A / 18_36195416_C_T | 0.00045986586717034416 / 0.0014799368107284092 / 0.001731239408871138 | 3.5975000177046293e-13 / 0.007257645332317387 / 0.011340791435594116 |
| 491 | TBC1D1_2 | 4_37920795_A_T / 4_38102880_CA_C | 0.000488440493483436 / 0.0003703609091265926 | 0.005935046245136817 / 0.0040311926239692975 |
| 492 | MYOF_6 | 10_93402739_A_T / 10_93335910_A_G / 10_93341723_C_T / 10_93349980_G_A / 10_93456833_C_T / 10_93379679_T_C | 0.0005166123667663002 / 0.008644559399569549 / 0.030314897647199957 / 0.007378711399757192 / 0.014254715712501044 / 0.03684609798869681 | 0.008275987890594253 / 0.013383779511641422 / 1.0154009952651607e-05 / 0.013694532403103154 / 4.5730649026336375e-05 / 0.0006543495060757152 |
| 493 | RBBP5_4 | 1_205096605_G_T / 1_205105296_C_T / 1_205121757_C_G / 1_205101436_A_G | 0.0005227440198400762 / 0.00526416157273805 / 0.0030657012636972646 / 0.0013099169827028106 | 0.015139833707904771 / 0.008644227461685475 / 0.012113677398994695 / 0.04046396583686459 |
| 494 | CLASP2_2 | 3_33577059_G_GA / 3_33684322_GA_G | 0.0005299045117610777 / 0.035952102365944434 | 0.0005875510468728085 / 0.0001503619637647613 |
| 495 | PHACTR1_2 | 6_13206050_C_T / 6_12749854_G_C | 0.0005337924756049767 / 0.004317442990912475 | 0.00039532970764163586 / 0.035334891294853864 |
| 496 | ANAPC4_3 | 4_25396670_G_C / 4_25396674_T_G / 4_25405734_A_G | 0.0005663311621920986 / 0.0013075373037905336 / 0.0465779350486673 | 0.000361328058170187 / 0.03220079967613157 / 0.0019550422066677508 |
| 497 | PSMD5_2 | 9_120820914_A_G / 9_120824459_T_G | 0.0005809565738534683 / 0.0007453253514985393 | 0.02520354146772891 / 0.030923039758435706 |
| 498 | ABCC3_4 | 17_50677651_A_G / 17_50687493_T_G / 17_50677654_A_G / 17_50661130_G_A | 0.0006252991041556168 / 0.01577297864138986 / 0.003896335000953405 / 0.0010188260367160796 | 0.031817085633522264 / 0.0088751921752167 / 0.04421726142800319 / 0.010430910480796323 |
| 499 | PDS5A_8 | 4_39826222_A_G / 4_39908552_GA_G / 4_39920322_A_G / 4_39928282_TCA_T / 4_39874433_GT_G / 4_39902522_ATT_A / 4_39922752_TAA_T / 4_39849438_CAA_C | 0.0006804734038066716 / 0.0008478404674630213 / 0.0026866381085943365 / 0.00132808107004332 / 0.004772686052629922 / 0.0001500621143076567 / 0.007431666608049384 / 0.000683239660165417 | 0.013430761436295064 / 0.011566738826207195 / 0.012551712088653194 / 0.04498488242774648 / 0.0069892257136405615 / 0.002775620894064112 / 0.00845393532716467 / 0.015679705858385958 |
| 500 | ARID1B_3 | 6_157084627_G_A / 6_157084796_G_A / 6_156779262_G_GCGC | 0.0006899056725067633 / 0.00012305812201489173 / 0.003772804433314189 | 0.002480449952777213 / 0.003319459056638543 / 0.0297382920893214 |
| 501 | ATP6V1D_2 | 14_67347484_T_C / 14_67347517_C_T | 0.0006971003770886628 / 0.004311412775348075 | 0.0458931703260112 / 0.04673425843690365 |
| 502 | TSPAN15_2 | 10_69506088_T_G / 10_69506076_T_C | 0.0007322830521084773 / 0.005306461981362982 | 0.002401654647845401 / 0.00014212528801531312 |
| 503 | MLH1_3 | 3_37007142_A_G / 3_37012077_A_G / 3_37042249_A_G | 0.000740971042730754 / 0.00173625605182141 / 0.0001471514352872128 | 0.0011032555560560838 / 0.0188504234858543 / 0.00278116952700519 |
| 504 | MCPH1_10 | 8_6563013_A_G / 8_6414878_G_T / 8_6415022_A_C / 8_6442011_A_G / 8_6444662_G_C / 8_6621439_C_G / 8_6621761_G_T / 8_6643023_C_T / 8_6643230_C_G / 8_6445504_G_A | 0.0007930301578494862 / 0.00783515709942311 / 0.0010653421345075958 / 0.01109994940299345 / 0.01748605668447073 / 0.014338437252537204 / 0.004071842491061435 / 0.0006919647053001271 / 0.012376440045340064 / 4.6837103256950894e-05 | 0.013491192511465546 / 0.00030214631498362885 / 1.4308699249286362e-06 / 0.000801511853950485 / 0.0006599247173344139 / 0.00022140087416861568 / 6.162352636469756e-05 / 4.2830362262517274e-05 / 0.0016916243554951818 / 0.00023822828634849838 |
| 505 | APLP2_2 | 11_130110790_G_A / 11_130141602_T_C | 0.0008186783504663072 / 0.005144250183511083 | 0.0021295365540794004 / 0.003817157441436617 |
| 506 | GDF11_2 | 12_55743444_T_G / 12_55743453_A_G | 0.0008261007388543191 / 0.03983988128537546 | 0.0038399667498981156 / 0.009308695658692865 |
| 507 | DHRS1_2 | 14_24296416_G_A / 14_24296478_G_A | 0.0008309168215997886 / 0.0004203355659529219 | 0.0011625249597744401 / 0.0009759887418146756 |
| 508 | HMBOX1_2 | 8_29019076_C_G / 8_29049138_T_G | 0.0008669919525569822 / 0.03171806222754735 | 0.004301459569275475 / 0.002544858829830765 |
| 509 | FAM129B_3 | 9_127525147_A_C / 9_127531490_GA_G / 9_127578821_C_G | 0.0008771327036108232 / 0.0021288478614580747 / 0.0022519852618096852 | 0.020053464930431048 / 0.031013612085774283 / 0.0009666899162254512 |
| 510 | SQRDL_3 | 15_45676245_C_G / 15_45659211_A_T / 15_45659215_T_A | 0.0008907771597097484 / 0.0020094614120517293 / 0.009204846533756823 | 0.014234174047984662 / 0.023564046281648054 / 0.01334902621156353 |
| 511 | PAWR_3 | 12_79621127_A_T / 12_79621127_A_C / 12_79690012_G_C | 0.0008953392161992621 / 4.018282599405261e-05 / 0.00946824676498348 | 0.00916697548400727 / 0.004195646894367022 / 0.04023621560178265 |
| 512 | ZMYM4_2 | 1_35386039_A_G / 1_35398970_A_G | 0.0009255268514009688 / 0.0010268025209398274 | 0.047414902378186935 / 0.03220211892803819 |
| 513 | PNISR_3 | 6_99400577_G_T / 6_99400380_A_T / 6_99400680_T_C | 0.0009649647745143484 / 0.0007159697124499053 / 0.04773876660712681 | 0.00024058514444646938 / 0.04850971607266792 / 4.045878429706501e-05 |
| 514 | KCTD1_2 | 18_26455686_TTTTG_T / 18_26455824_G_A | 0.0009651254517760071 / 0.00044897282981570764 | 0.011878660133524677 / 0.022677959399150814 |
| 515 | YEATS4_4 | 12_69360050_G_A / 12_69360067_T_C / 12_69365771_AT_A / 12_69359732_G_C | 0.0009657838134951767 / 0.010865427433622845 / 0.00010196861904854136 / 0.004781622790417561 | 0.00020734016607029562 / 9.576513142549652e-05 / 0.005769237544482665 / 0.00015854860163792644 |
| 516 | MYH14_4 | 19_50257459_C_G / 19_50268152_A_C / 19_50223372_A_C / 19_50210705_A_C | 0.0009907478792200786 / 0.00031027234534027856 / 0.009603188672713292 / 8.610623849100771e-05 | 0.003155642857162157 / 0.02679430539669753 / 0.04503905394492344 / 0.01011266806040028 |
| 517 | TNRC6B_3 | 22_40246081_G_A / 22_40322746_C_G / 22_40270313_CTT_C | 0.0010055560691593062 / 0.007906209412661305 / 0.009164202590452458 | 0.0005779404176446281 / 0.0047436478866502065 / 0.0364705418337816 |
| 518 | INTS9_7 | 8_28780706_C_T / 8_28787754_C_T / 8_28793781_A_C / 8_28793783_A_C / 8_28835266_C_T / 8_28775581_A_C / 8_28775811_A_C | 0.0010081741289715016 / 0.004592362992120706 / 0.0005120698884621372 / 0.0002773767656391789 / 0.02714848429874154 / 0.00020236348372473448 / 2.4854306942254155e-05 | 3.2138156864211546e-07 / 5.188443093736729e-09 / 4.024976616918393e-06 / 2.0930318384840388e-05 / 1.818850464108077e-06 / 3.257318543578891e-07 / 0.018623738854211223 |
| 519 | SLC9A2_2 | 2_102708404_T_C / 2_102683152_T_C | 0.0010228970665369316 / 0.0005020081620733607 | 0.009615984790689362 / 0.009480536166577638 |
| 520 | CABYR_2 | 18_24159761_T_C / 18_24143046_A_T | 0.0010567833091170056 / 0.0014968601112293539 | 0.005047158957377522 / 0.04396847891686953 |
| 521 | GTF3A_3 | 13_27435783_G_C / 13_27434894_G_C / 13_27424632_T_C | 0.0011190222584791265 / 0.004681955550098893 / 0.007918207229892667 | 6.8305505569380366e-06 / 4.651074413645253e-05 / 0.009084963551764854 |
| 522 | C17orf80_2 | 17_73243051_A_T / 17_73243095_T_G | 0.0011654886198261731 / 0.004494422448579687 | 0.010085515976883222 / 0.004743723689710052 |
| 523 | SMU1_3 | 9_33042147_G_GC / 9_33048282_A_C / 9_33062151_T_C | 0.0011669696398791268 / 7.696816352170192e-06 / 0.01499894245869885 | 0.04706645923394905 / 0.031220105263435657 / 0.0036210535474734524 |
| 524 | APP_3 | 21_25881669_T_G / 21_25982373_C_A / 21_26053118_T_G | 0.0011674640267523098 / 9.245713138747127e-05 / 0.004308340981093568 | 0.0009005203285702301 / 0.013334900192842466 / 0.04036723851049838 |
| 525 | SF3A2_2 | 19_2247907_A_C / 19_2248684_C_T | 0.0012266864812599976 / 0.002990131415570729 | 0.0030981828107111728 / 0.0468855780292127 |
| 526 | MCM3AP_14 | 21_46242985_CA_C / 21_46245202_GAAGA_G / 21_46254361_G_A / 21_46256797_G_A / 21_46257020_T_C / 21_46258860_A_G / 21_46261213_T_C / 21_46265873_T_C / 21_46266025_A_G / 21_46266238_C_T / 21_46266260_T_C / 21_46272884_C_T / 21_46275481_C_G / 21_46285323_T_C | 0.0012527393891514607 / 0.00036535930217642055 / 0.0024609384326425487 / 0.04643229751040803 / 2.118510728826028e-05 / 2.887414182548247e-06 / 1.05276826358399e-07 / 0.00025970635193207507 / 0.0005620952054741439 / 5.716570824504117e-07 / 2.4174995461629513e-07 / 0.005818667124032619 / 0.0467983305638919 / 8.653902898907501e-05 | 0.0002736694696369044 / 1.7616074069549246e-05 / 1.3003369428929314e-06 / 2.3123117180340123e-05 / 2.0562643179742515e-06 / 8.354163607590267e-05 / 0.00029806921327546384 / 5.3648509797744586e-06 / 1.5227506753175702e-05 / 7.251148442399709e-05 / 0.00010743801329645878 / 1.1615547532865214e-07 / 1.858126949270524e-05 / 3.8129306546053804e-06 |
| 527 | CLIP4_2 | 2_29160508_G_A / 2_29167435_A_G | 0.001256177781998004 / 0.0032393618837062445 | 0.004054702946614456 / 0.02363327883448803 |
| 528 | TSC22D1_3 | 13_44574373_G_T / 13_44574380_T_G / 13_44573675_A_G | 0.001377124084836583 / 0.015722049040498624 / 0.02470162730235456 | 0.0064804726533923464 / 0.0020304861527569297 / 5.907708401459935e-06 |
| 529 | PKP3_3 | 11_403980_G_A / 11_404317_C_T / 11_397331_G_C | 0.0013876622699982295 / 0.016481995505848203 / 3.1228708373215485e-07 | 0.018674886861837936 / 0.009799627021991927 / 0.04880244320980319 |
| 530 | CASP8AP2_4 | 6_89867828_C_A / 6_89846678_CT_C / 6_89854793_T_G / 6_89867387_T_G | 0.0013957399418989352 / 0.0012351347166879073 / 0.01485793169450881 / 0.029929799896047743 | 0.004638447540709211 / 0.00012650141154496166 / 0.0049509957510286366 / 0.007919221858804896 |
| 531 | SUGP1_3 | 19_19297181_T_G / 19_19320614_T_G / 19_19321154_G_T | 0.001497727430536191 / 0.0019392453885837852 / 1.1604792778575085e-06 | 0.004713359874536658 / 0.0005015062282813169 / 2.8690586178505662e-05 |
| 532 | MTMR14_2 | 3_9701714_TGGAG_T / 3_9688859_C_T | 0.0015228522402605245 / 0.0034777774244127892 | 0.0064175485415249155 / 0.007328897092709648 |
| 533 | RIOK2_2 | 5_97167674_T_C / 5_97179013_C_G | 0.0015264299232640686 / 0.0009434563320843556 | 0.018107759921786072 / 0.01839083931192911 |
| 534 | HCLS1_5 | 3_121631746_C_A / 3_121642799_G_A / 3_121642940_G_A / 3_121647276_C_T / 3_121647530_A_G | 0.001531370286315401 / 0.007140010061027548 / 0.0056491920403494 / 0.0056491920403494 / 0.0033035345652737084 | 0.008666157872154578 / 0.028236059065420614 / 0.02925717871219745 / 0.02925717871219745 / 0.035251625940568736 |
| 535 | USP20_2 | 9_129868385_TGAC_T / 9_129868775_T_C | 0.001542609843192008 / 0.006644626432996628 | 0.028200134219961023 / 0.0362382211673806 |
| 536 | OGT_3 | X_71555839_AT_A / X_71555852_A_G / X_71556880_G_A | 0.0015512975406232336 / 0.0006090442157279421 / 3.794330620993244e-05 | 0.03251106613283236 / 0.03051485289420325 / 0.02757062507023744 |
| 537 | ILF3_4 | 19_10677068_C_G / 19_10683073_A_G / 19_10683954_G_T / 19_10689074_T_C | 0.0015595887966999382 / 0.0008443307208163777 / 0.0014177004651836508 / 0.006992884477782401 | 0.02905299869911714 / 0.023662506952371584 / 0.024462171404793464 / 0.04401306590016355 |
| 538 | AKAP17A_6 | X_1593528_G_T / X_1593824_T_C / X_1593829_A_C / X_1593416_T_G / X_1599467_G_A / X_1601004_C_G | 0.0016145426205006856 / 0.006626142886833432 / 0.0006549722036186197 / 1.3622821646377586e-09 / 1.4367220837077828e-05 / 0.0013113963664485734 | 1.7500984806304813e-06 / 0.004424305821371996 / 0.031339887946813465 / 0.0002164120997390045 / 0.0019808227552202268 / 0.022975239267281157 |
| 539 | HLA-DPB1_25 | 6_33084838_T_C / 6_33086094_A_G / 6_33086100_G_A / 6_33086430_A_G / 6_33086431_C_T / 6_33086458_T_G / 6_33086503_T_C / 6_33086504_G_A / 6_33086525_T_C / 6_33084940_A_C / 6_33084942_G_A / 6_33084946_C_G / 6_33084959_G_A / 6_33086548_G_C / 6_33086623_T_C / 6_33086627_A_G / 6_33086636_T_G / 6_33086637_T_A / 6_33084934_T_C / 6_33086390_G_A / 6_33086399_T_A / 6_33086400_T_C / 6_33086554_T_C / 6_33086565_T_A / 6_33084918_T_G | 0.0016170360777901915 / 0.035517335536449965 / 0.03859616732889496 / 0.0050484605719981115 / 0.006920322099559346 / 0.04723136941351201 / 0.01042058063158112 / 0.01982161136592692 / 0.004676661817713314 / 9.909297446240884e-05 / 0.00013864663028350917 / 0.0002553757712440544 / 0.00010148054048444211 / 0.0005733999890735651 / 0.001447191231242919 / 0.0006504207970493822 / 0.0014159972834331574 / 0.0011151099996242373 / 1.670066308093462e-07 / 0.002181120675090949 / 0.001551134422399547 / 0.001551134422399547 / 0.00018558558739674276 / 0.00027961484945332547 / 0.04098305035004495 | 0.01738899621763897 / 0.0071970972262367875 / 0.0015085198751619124 / 0.009855204235078744 / 0.009159540445250336 / 0.0034148006003537623 / 0.0007725393378843376 / 0.00046914802311591013 / 0.0002211234236168895 / 0.01812705600921171 / 0.02551712776803155 / 0.02768815887474311 / 0.01961732896362046 / 0.00424548612011435 / 0.03272474670019398 / 0.034386513937956574 / 0.03829938821939845 / 0.02718298788851184 / 0.0008766728067700178 / 0.0010412174325617669 / 0.00027430911944352433 / 0.00027430911944352433 / 0.007068880728833383 / 0.0015589855961860727 / 0.0023729962607638784 |
| 540 | ERBB2_7 | 17_39723335_A_G / 17_39725167_A_G / 17_39727303_T_G / 17_39723531_A_C / 17_39728154_A_C / 17_39709434_A_C / 17_39728753_A_G | 0.0016350878443782172 / 4.136237081824547e-05 / 0.046602377151608726 / 0.0033861558195955052 / 0.0037588249676302338 / 0.03412502593916668 / 0.0037443415073794024 | 0.030443197190865717 / 0.016249088634527818 / 0.0009745478853255011 / 0.014043142620610086 / 0.002489169967351341 / 0.005151661954164628 / 0.0238332618696792 |
| 541 | CNOT10_5 | 3_32773739_A_T / 3_32705030_A_G / 3_32717271_G_A / 3_32727933_TAA_T / 3_32704796_GT_G | 0.0016526003311275095 / 0.0001231320148601887 / 0.00017728596732259782 / 0.009536795008099045 / 0.003991838672618705 | 0.0019461949221222566 / 0.0007110070373588129 / 0.0032142136890770555 / 0.009535253937430231 / 0.00725632017358903 |
| 542 | BTAF1_3 | 10_91959744_A_G / 10_91959746_A_G / 10_92024732_G_GTTTTTTTGTT | 0.0016639394777511788 / 0.017417232932444852 / 0.002725136934144748 | 0.0011854132574195902 / 0.002486161819230707 / 0.02294891315626264 |
| 543 | KDM2B_2 | 12_121579961_G_A / 12_121444386_T_G | 0.0016808767205032673 / 0.0018129427277068664 | 0.04715734536774355 / 0.019501973878425127 |
| 544 | OSBPL8_3 | 12_76371622_A_G / 12_76459031_C_T / 12_76389816_G_A | 0.001685976661542144 / 0.0019376612844524102 / 0.00034069060776455845 | 0.010145024239484482 / 0.023570151478943115 / 0.01081801975958232 |
| 545 | SPATS2L_4 | 2_200477598_G_T / 2_200412421_T_G / 2_200477943_T_G / 2_200473083_GAA_G | 0.0017077762924250339 / 0.005542406637614594 / 0.008957206491580714 / 0.02371288438579117 | 0.021972245787165747 / 0.03547678698863923 / 0.016080388811817628 / 0.0009052273948575811 |
| 546 | KMT2C_2 | 7_152273692_G_A / 7_152177504_T_G | 0.0017215770748878 / 0.0257040166730586 | 0.02044755694417402 / 0.0007976241891358237 |
| 547 | C3_8 | 19_6679370_G_T / 19_6679500_C_T / 19_6679552_T_C / 19_6693625_A_G / 19_6710771_G_T / 19_6713164_G_C / 19_6713251_G_A / 19_6718376_G_C | 0.0017242987096359706 / 0.011130009901872313 / 0.01112305118572054 / 0.03308700773309592 / 0.0007547726119911367 / 2.8401856724118085e-05 / 9.337374703033051e-05 / 0.00015757450123976866 | 0.021139612203482698 / 0.001328408206242609 / 0.0024788445051524576 / 0.009567716450671235 / 0.00949274728217466 / 0.015144191214707904 / 0.01135067374028043 / 0.013151961372936128 |
| 548 | NFX1_3 | 9_33290534_A_G / 9_33290690_G_C / 9_33344254_T_A | 0.0017340354418381332 / 0.00213071003554307 / 0.0008944872419168263 | 0.004533123491706767 / 0.03459515757598255 / 0.005356381351212509 |
| 549 | KATNAL2_4 | 18_46963135_T_TGC / 18_46969062_T_TGC / 18_47028569_T_TGC / 18_47069438_A_T | 0.0017826363249020844 / 0.0002158210829164119 / 0.002959998960433205 / 1.0166082620431142e-06 | 0.023566439092900897 / 0.042581318341999685 / 0.01792891562738572 / 0.04594422713064072 |
| 550 | PLRG1_8 | 4_154538042_A_T / 4_154539961_T_C / 4_154540535_A_C / 4_154540996_A_T / 4_154544383_A_G / 4_154545783_T_C / 4_154546035_A_G / 4_154548807_G_GA | 0.0017837327552204187 / 0.0022747756662197635 / 0.013232282684609756 / 0.006089524083842604 / 0.023466965037692716 / 0.011286717487280188 / 0.015766497021373137 / 0.001132424851953552 | 0.0025156591482322463 / 0.003876861205834139 / 0.008064183834782563 / 0.004736898325652559 / 0.004629934695328492 / 0.00625636632504058 / 0.006403275082048386 / 0.0051675452547446255 |
| 551 | EDN1_2 | 6_12295840_T_G / 6_12295843_T_G | 0.00181409210724337 / 0.0002763328454078789 | 0.024241257142762068 / 0.012273310260196891 |
| 552 | RABEP1_2 | 17_5381248_TAA_T / 17_5361621_C_T | 0.0018150712755665734 / 0.004152920156402154 | 0.007056745600928623 / 0.01880219353285387 |
| 553 | RUNX3_2 | 1_24907301_T_G / 1_24907326_T_G | 0.001835528705698884 / 0.0008816631461578386 | 0.0479402881785652 / 0.03367486268556343 |
| 554 | ARID3A_2 | 19_929678_G_A / 19_965056_A_C | 0.001844502898018781 / 0.0038221459346221604 | 0.0024448512910076343 / 0.038475803182823655 |
| 555 | SETD2_6 | 3_47037622_G_A / 3_47083895_G_A / 3_47084411_A_C / 3_47084426_CT_C / 3_47101417_TCC_T / 3_47121171_A_G | 0.0018886443163515503 / 0.0005724676673950148 / 0.0018507014329319895 / 0.002298087295161151 / 0.0018577181187481573 / 0.000573845912909288 | 0.000977617083994294 / 0.008205866594339892 / 0.008011204119723829 / 0.009083566444260623 / 0.0015764712914139378 / 0.0002475067417184235 |
| 556 | MYO1E_4 | 15_59272288_G_C / 15_59223315_G_A / 15_59178167_C_T / 15_59138181_A_C | 0.0019255092745879315 / 0.027929898310990055 / 0.00031389151980896725 / 0.04411515555617615 | 0.006181875879725325 / 0.0073567891788311425 / 0.014590984354000915 / 0.000506485287819266 |
| 557 | SUGP2_5 | 19_19024510_A_G / 19_19025732_C_T / 19_18994964_G_A / 19_19026233_T_A / 19_19010089_T_G | 0.001983285518752092 / 0.002941993796204625 / 0.01284029709782453 / 0.0020741831309949127 / 0.0008037924072482433 | 0.040831519054544435 / 0.008182273259557721 / 0.005749298256034085 / 0.007605074821863024 / 0.027745888328438603 |
| 558 | KLHL18_3 | 3_47319581_T_G / 3_47344095_C_A / 3_47322481_G_T | 0.0021891626387678365 / 0.0006911454072889093 / 0.0001458644297550943 | 0.013218876001835087 / 0.0063137500959640856 / 0.018113274866617776 |
| 559 | TYSND1_2 | 10_70138599_C_T / 10_70140172_G_A | 0.002210990629147794 / 0.0039640911222843436 | 0.009659099597965872 / 0.027700702531791875 |
| 560 | EIF1B_5 | 3_40309993_C_T / 3_40311393_C_T / 3_40311934_CAG_C / 3_40311768_T_G / 3_40309649_C_G | 0.0022271726409335488 / 7.503385234156634e-05 / 3.177548305907501e-05 / 2.1365604310883664e-06 / 0.006831469965345718 | 0.005496962588873379 / 0.0028348307389023737 / 0.0036905138907599726 / 3.949648255514959e-06 / 0.04857611284248277 |
| 561 | C14orf79_2 | 14_104991443_T_G / 14_104992803_A_C | 0.0022393155386724074 / 0.009479451263550959 | 1.7720854995940125e-07 / 7.586102006604381e-07 |
| 562 | SLC52A3_2 | 20_761203_A_G / 20_763790_T_G | 0.002271842149158581 / 0.0019785326127115858 | 0.0003747217630289052 / 0.003089764091274667 |
| 563 | HDAC5_2 | 17_44087216_A_G / 17_44077102_A_G | 0.0022775299741103626 / 0.009100177186215046 | 0.03161998848113075 / 0.021561030479614426 |
| 564 | TCF7L2_4 | 10_112951117_C_T / 10_113165703_A_C / 10_113165557_GA_G / 10_113141157_T_G | 0.0023062734857754803 / 0.006196689121801137 / 0.00015949311848004983 / 0.01042058063158112 | 0.01060529288873283 / 0.008309178089758909 / 0.04233413143117931 / 0.004504822920252362 |
| 565 | DSP_2 | 6_7577915_A_C / 6_7581379_A_G | 0.002345981327408041 / 0.02625851263459552 | 0.0018316675069518392 / 0.005935959963292785 |
| 566 | GAS7_3 | 17_9943314_G_A / 17_9943407_C_A / 17_9940079_A_C | 0.0024862474118096554 / 0.02161659825841676 / 0.01209844734945125 | 0.014304203615809547 / 0.007643530014898026 / 0.02182596122662912 |
| 567 | ARHGEF5_5 | 7_144365079_A_C / 7_144371121_T_C / 7_144371117_T_G / 7_144364997_T_C / 7_144365475_T_C | 0.0024945926126355923 / 0.02354548207827752 / 0.006211748094610735 / 0.002934715516170928 / 1.727507617843059e-06 | 0.02343547139067424 / 0.007520412833757487 / 3.130275501973943e-06 / 0.02778730920062768 / 0.003065464879158348 |
| 568 | PTPRU_3 | 1_29275579_A_C / 1_29310715_T_G / 1_29255395_A_C | 0.002539773248455689 / 0.0077226993558171956 / 0.0009778041944005973 | 0.007805553893565897 / 0.021084479691732515 / 0.046498222792818684 |
| 569 | TTC39A_2 | 1_51288088_T_G / 1_51295930_G_T | 0.002570863553329518 / 3.4909921895622464e-05 | 0.0009000808652072745 / 0.009859747746545187 |
| 570 | KRT15_3 | 17_41516910_C_A / 17_41518370_T_G / 17_41518744_A_C | 0.002573274763251264 / 0.011567941016623695 / 0.003420135618507444 | 0.005435309336568784 / 0.004600527769071169 / 0.020891294013713143 |
| 571 | UBXN8_5 | 8_30744093_TC_T / 8_30744288_C_T / 8_30751256_A_G / 8_30751544_T_G / 8_30751561_A_T | 0.002591192476579632 / 0.0006909486125387932 / 0.02443874890142141 / 0.03582659928743899 / 0.03582659928743899 | 1.0603773748192244e-05 / 4.865545060608271e-05 / 6.152112049146202e-05 / 3.811929186552625e-05 / 3.811929186552625e-05 |
| 572 | SMARCA4_3 | 19_11003321_G_T / 19_11010261_C_T / 19_11026459_T_C | 0.002630441388397466 / 0.010463060303081006 / 0.010088756192701873 | 0.010970724428159849 / 0.007818649393052565 / 0.008366105586796981 |
| 573 | PSMD6_2 | 3_64018733_C_CA / 3_64023832_T_C | 0.0026976125076584256 / 0.009878175034845338 | 0.010870617478385693 / 0.0044822108745555264 |
| 574 | CCDC18_7 | 1_93226524_AAT_A / 1_93232665_C_G / 1_93180876_T_C / 1_93221838_T_C / 1_93239253_G_A / 1_93226314_TG_T / 1_93180563_T_G | 0.0027123682464393244 / 0.0016657739488188466 / 0.0033797977817805816 / 0.0015978624867728733 / 0.002134999320804664 / 0.013590020119742256 / 0.003793743444563949 | 0.04835531632243841 / 0.0045740699346053185 / 0.00032147121850177287 / 0.0017542576026547778 / 0.0017542576026547778 / 0.003812032810040999 / 0.0440564257256616 |
| 575 | MKRN2_2 | 3_12572367_T_C / 3_12576770_C_T | 0.0027864675750747985 / 7.698740851570175e-06 | 0.0004133954800997532 / 0.00023875055451781275 |
| 576 | POU2F2_2 | 19_42122415_A_C / 19_42116791_T_G | 0.002831354927429977 / 0.00132487414614545 | 0.0009318465407261826 / 0.03195305321524156 |
| 577 | CSNK1G2_2 | 19_1941300_C_CG / 19_1978367_A_C | 0.002838297409364801 / 0.002057750736247525 | 0.0019266812436141687 / 0.04165592627236607 |
| 578 | NADK_4 | 1_1754601_G_T / 1_1755504_T_C / 1_1755523_C_T / 1_1757030_C_G | 0.0029196774804306136 / 0.0022487075080235863 / 0.0010425578675322944 / 0.004582127513664698 | 0.031872533533518106 / 0.005752610352558396 / 0.0031781335571060463 / 0.03556781287056178 |
| 579 | CD151_2 | 11_837662_TG_T / 11_835877_C_T | 0.003028852216804449 / 0.04104019245722205 | 3.3851264417503082e-06 / 0.005759250847020773 |
| 580 | ATP5A1_9 | 18_46098069_T_C / 18_46086016_C_T / 18_46086895_T_C / 18_46086986_C_A / 18_46087562_T_C / 18_46088355_G_T / 18_46090014_T_C / 18_46098295_T_G / 18_46090084_G_T | 0.0030434677700528394 / 0.0004952827031339936 / 0.007810554102540824 / 0.000648733348082285 / 0.013897849420604671 / 0.002385765549363269 / 0.0010062790676919331 / 0.005315177457540565 / 0.01959258956571804 | 0.0003047097440701736 / 0.0142075393191002 / 0.036323160579493724 / 0.013872652612254888 / 0.0036567482317310593 / 0.02085147005163321 / 0.01507674177782532 / 0.03454712220311499 / 0.007087269321528623 |
| 581 | ACTR8_2 | 3_53876892_G_GT / 3_53876872_GA_G | 0.003050264516832101 / 0.008934315374097621 | 5.979539416096826e-07 / 0.005988354207232076 |
| 582 | KDM4C_3 | 9_7105548_G_C / 9_7170165_G_A / 9_7174813_T_A | 0.003056285777006115 / 3.848309807154845e-06 / 0.028252899669062883 | 0.04853749604959928 / 0.04549941716484139 / 0.006907446061910031 |
| 583 | AZI2_2 | 3_28331971_C_CA / 3_28340396_A_T | 0.0031048857689516462 / 0.003592307504254993 | 0.014552320913166257 / 0.004305743220750069 |
| 584 | SERTAD4_2 | 1_210241533_TC_T / 1_210241536_T_C | 0.003132119859215549 / 0.009639231593611885 | 0.019963608830813308 / 0.006491338228956634 |
| 585 | USP15_4 | 12_62302696_T_G / 12_62383784_G_T / 12_62404146_G_T / 12_62335441_G_C | 0.0031338510061822643 / 0.014094139089898441 / 0.0031672583932668176 / 0.002293994252085232 | 0.00033081922207003954 / 0.0033557619531166464 / 0.00033479875073063453 / 0.039619833047337696 |
| 586 | DOCK1_3 | 10_127012556_G_A / 10_127444251_G_A / 10_127248024_G_T | 0.0031585127425178675 / 0.027688640963832358 / 0.0004879172723173928 | 0.004938898221400919 / 0.007801850145866487 / 0.020184142497530616 |
| 587 | ITGB4_4 | 17_75736347_G_A / 17_75739839_G_A / 17_75742534_T_C / 17_75754823_A_C | 0.003162157220078509 / 0.008328692436238487 / 0.007894779942929558 / 0.009860822677928005 | 0.01217344559335353 / 0.002457354260511787 / 0.01159864028497844 / 0.005496381411893582 |
| 588 | ZDHHC17_2 | 12_76843188_G_A / 12_76815330_A_G | 0.0032793703796479517 / 0.0004434027342669209 | 0.011228793208829205 / 0.0047926477879100746 |
| 589 | STEAP4_2 | 7_88282586_G_A / 7_88283906_C_T | 0.003287923696320924 / 0.0091566014690908 | 0.020956268813510096 / 0.020511289316670928 |
| 590 | SON_2 | 21_33553093_A_C / 21_33553095_T_C | 0.003287986051022628 / 0.0002182856164179604 | 0.023262781799198717 / 0.04085529307129965 |
| 591 | SUZ12_2 | 17_31937449_T_G / 17_31937443_C_G | 0.0032919118028606463 / 5.6901277653871055e-05 | 0.001414433092115542 / 0.02301260051890533 |
| 592 | ZNF708_5 | 19_21294577_C_T / 19_21309149_T_A / 19_21309260_G_A / 19_21294601_T_G / 19_21310453_A_T | 0.003305225750188495 / 0.0035049021956979373 / 0.004520698246333428 / 0.0002495831365867789 / 0.0067675270617948155 | 0.007544201865148675 / 0.008126720123629898 / 4.891895383413758e-05 / 0.0371668734968966 / 0.010566885319869566 |
| 593 | NPAT_3 | 11_108173261_C_T / 11_108188273_T_C / 11_108222481_A_T | 0.003344965508099712 / 0.00917775939993597 / 0.039703241026176714 | 0.002496786878352684 / 0.04574657942913745 / 0.0037813176541691743 |
| 594 | HSPG2_4 | 1_21848107_A_G / 1_21857246_A_G / 1_21854055_T_C / 1_21885485_A_C | 0.003347609104205378 / 0.0006068526113653472 / 0.003704007084337551 / 0.00357256954025205 | 0.02697977272492986 / 0.03734459078034153 / 0.0018455746031783011 / 0.028105372966297285 |
| 595 | TOP2B_6 | 3_25618603_G_GT / 3_25620066_T_TA / 3_25630287_C_T / 3_25632344_A_C / 3_25632600_C_A / 3_25638247_T_C | 0.0033763968792717173 / 0.008450908635462133 / 0.0012336549489001688 / 0.00024044846753362568 / 0.0010363758807633305 / 0.0007533307901546944 | 0.009406841430847504 / 0.006029442482514222 / 0.011303133266640238 / 0.01883862996744124 / 0.018119501937010576 / 0.00877690000990295 |
| 596 | MUC16_3 | 19_8894929_A_T / 19_8979498_T_G / 19_8957088_C_T | 0.0034029575974152395 / 0.00041258558252529193 / 0.001514661605616884 | 0.03041637790901308 / 0.002432253712629655 / 0.03213344574711092 |
| 597 | TMEM144_3 | 4_158244471_A_C / 4_158253356_T_G / 4_158253361_T_G | 0.0034876691228988683 / 0.0005647077594982514 / 0.0008326481477321537 | 8.607739077270522e-05 / 6.799118981257274e-05 / 0.0018072956471693355 |
| 598 | SDC1_2 | 2_20204203_T_G / 2_20202279_A_C | 0.003538404752618725 / 0.0156379764488537 | 0.012274967718012342 / 0.005607450656810002 |
| 599 | RBM6_7 | 3_50054242_G_T / 3_50054246_C_T / 3_50054250_C_T / 3_50054257_G_T / 3_50054263_T_G / 3_50075177_T_G / 3_50066484_G_A | 0.0035570559373772188 / 0.00580221866025999 / 6.528791603289091e-07 / 0.001554315699435568 / 0.0007276852324929738 / 0.008508212434548797 / 0.002518709860742996 | 0.0124136469122058 / 0.0004024483543288937 / 3.272618868931358e-05 / 5.8729619078742086e-05 / 0.00033057063887385755 / 0.000930075295183941 / 0.014325869585835831 |
| 600 | FIP1L1_2 | 4_53377738_T_C / 4_53414538_G_GA | 0.003618394551763958 / 0.000808630514933739 | 0.020612870650917825 / 0.014620279830838013 |
| 601 | BAZ1A_6 | 14_34773800_G_A / 14_34761774_C_T / 14_34761902_A_T / 14_34771458_C_G / 14_34780118_A_G / 14_34862082_G_A | 0.003674207621815091 / 0.00048794862757524084 / 0.0004529362621637724 / 0.00048794862757524084 / 0.0004529362621637724 / 0.0008633899521319537 | 0.020819109086183382 / 0.029434275834813995 / 0.038030144241646684 / 0.029434275834813995 / 0.038030144241646684 / 0.029434275834813995 |
| 602 | ABLIM1_2 | 10_114468289_G_T / 10_114613516_C_T | 0.003679575880821695 / 2.068694569003633e-05 | 0.013324532381057309 / 0.007365229118612223 |
| 603 | KCTD11_3 | 17_7356629_G_T / 17_7356036_T_C / 17_7353417_T_G | 0.003754571069046404 / 0.00017366868689943718 / 0.0012390848435611386 | 0.04600482755406116 / 0.034157938547959045 / 0.0012683162409826913 |
| 604 | MICALL2_5 | 7_1442358_T_G / 7_1448634_T_G / 7_1438692_G_A / 7_1438940_G_A / 7_1434765_T_C | 0.0037969325863282813 / 0.03384278289950645 / 0.029060946696468106 / 0.029060946696468106 / 0.0032003913710269877 | 0.003849439864891702 / 0.00957207447144348 / 0.001706040259270731 / 0.001706040259270731 / 0.009156797658911076 |
| 605 | RFC1_4 | 4_39304977_A_C / 4_39317086_A_G / 4_39327482_G_A / 4_39366034_T_C | 0.003804607068014229 / 0.002653298567768597 / 3.2670263647126826e-05 / 0.042208647376131 | 0.0020300192179148733 / 0.00027426635734190813 / 0.008638827908989666 / 0.0022061266378501725 |
| 606 | AP1M2_5 | 19_10572926_C_T / 19_10579645_C_T / 19_10587097_A_G / 19_10587125_G_T / 19_10579014_TC_T | 0.0038087692058226532 / 8.991675208563765e-05 / 1.1792724900645332e-05 / 5.261102684897293e-05 / 0.001877531631940374 | 0.02140839327697613 / 0.010527568877864577 / 0.0015316982164778213 / 0.023908631854345174 / 0.00821632833656041 |
| 607 | RPS23_2 | 5_82278173_C_T / 5_82278363_C_T | 0.003957786808705407 / 0.0008315075457503006 | 7.911328672036997e-05 / 2.402875788954321e-05 |
| 608 | BARX2_2 | 11_129436792_A_C / 11_129436677_C_T | 0.004015743982394933 / 3.8908364285059496e-05 | 0.0011297752143511178 / 0.006988734279853065 |
| 609 | LRRC1_3 | 6_53913863_T_G / 6_53920478_C_A / 6_53899709_T_G | 0.004131339558552957 / 0.0030469251357492584 / 1.3663885062737747e-07 | 0.02863343366704425 / 0.016849492489466617 / 0.0009777953947081833 |
| 610 | POGZ_3 | 1_151423306_T_C / 1_151407350_A_C / 1_151459156_T_C | 0.0041738932600083895 / 8.993795886819927e-07 / 0.008612349643764727 | 0.020015181832936737 / 0.02909488569964382 / 0.009809035888391762 |
| 611 | PRKCI_2 | 3_170275187_CTTT_C / 3_170263168_CAAAAA_C | 0.00425052374891476 / 0.002760121279997125 | 0.00012798467543814748 / 0.021989752739530143 |
| 612 | PGBD1_2 | 6_28296652_T_G / 6_28298177_A_T | 0.004288328285551539 / 0.00932669296817631 | 0.005702673764439882 / 0.020264770709017343 |
| 613 | LGALS8_3 | 1_236537373_GAGC_G / 1_236539197_AGTTT_A / 1_236551447_T_C | 0.00435552243438307 / 0.02490692830672263 / 0.005408439057885871 | 0.0007287918934518675 / 0.002689054589007359 / 0.013132223069499007 |
| 614 | CYP4F11_7 | 19_15913852_G_C / 19_15914366_C_T / 19_15924707_G_A / 19_15927524_G_A / 19_15927580_G_T / 19_15929482_A_G / 19_15929663_T_C | 0.004494422448579687 / 0.004118655653677505 / 0.009014030424870815 / 0.007737694175519336 / 0.005296914283554929 / 0.006573618747648885 / 0.0045029584577228 | 0.01037304937937457 / 0.022954596803030098 / 0.0124267741256932 / 0.011141708950444295 / 0.011312909542474079 / 0.016341169913201302 / 0.013422572430360932 |
| 615 | ZNF24_3 | 18_35337816_G_GA / 18_35337680_T_C / 18_35344446_G_A | 0.004517003572403403 / 0.00020451573869716152 / 0.02552298264953765 | 0.012709161524744772 / 0.04404021168973007 / 0.008269738810110396 |
| 616 | ANKS6_2 | 9_98796162_G_A / 9_98778486_A_C | 0.0045700537784898465 / 0.009257993261520582 | 0.047044500480316616 / 0.03370066145919663 |
| 617 | POLR2B_6 | 4_56995192_C_T / 4_57010789_G_A / 4_57015549_G_A / 4_57025073_G_A / 4_57005234_AT_A / 4_57023798_AT_A | 0.004738473697291275 / 0.00020500907676743697 / 0.0003428363180097953 / 0.00033030198738810576 / 0.000896266309671023 / 0.010078450270635015 | 0.00041802227600176717 / 0.03709404459710368 / 0.03851787302536296 / 0.03254648423802934 / 0.03704331970217288 / 0.007472844031288456 |
| 618 | CDC42BPB_3 | 14_102939620_T_G / 14_102952453_T_G / 14_102945931_T_C | 0.0049774861882444345 / 0.0002680622756333545 / 0.004938189506165365 | 4.775637628078603e-05 / 0.003315245095495249 / 0.001918499391114136 |
| 619 | WDR62_3 | 19_36058788_C_T / 19_36084743_G_A / 19_36094002_C_T | 0.005088637492213912 / 0.016915078735087723 / 0.007443859285838674 | 0.0005331846126391098 / 0.000415677937125236 / 0.0005211199976091131 |
| 620 | PLCB2_2 | 15_40298884_T_G / 15_40297623_G_A | 0.005308041472208479 / 0.0013941969299030182 | 0.025458039339188058 / 0.04960868971387879 |
| 621 | ZEB1_4 | 10_31461157_A_C / 10_31521191_A_C / 10_31521414_A_T / 10_31461247_AT_A | 0.005342806393282525 / 0.01137703502325166 / 0.0014780611664163069 / 5.800757504246017e-05 | 0.013618649263675358 / 0.006377825075174489 / 0.011119739548999731 / 0.0019400920584000448 |
| 622 | NDUFAF4_2 | 6_96891399_CA_C / 6_96896910_G_A | 0.005489763925784804 / 0.0005269475943804068 | 0.01909002509011261 / 0.009369364198285348 |
| 623 | PHIP_9 | 6_78947674_G_A / 6_78954723_T_C / 6_78955031_T_C / 6_78955493_T_A / 6_78969860_A_G / 6_78985312_C_T / 6_78998206_C_T / 6_79043075_T_C / 6_78947709_T_C | 0.005530164992886238 / 0.00548954353554207 / 0.01455660590235654 / 1.6913729880297845e-05 / 0.0035647193470514853 / 0.005289398736036421 / 0.001837097400913216 / 0.004209432623363282 / 0.02442132743404569 | 0.0010048550446085317 / 0.00648756713202656 / 0.0009432749408838033 / 0.009594339103514994 / 0.0017203137452171692 / 0.0007527047164367361 / 0.006763071535609179 / 0.0016364259457283912 / 0.0006553233953188175 |
| 624 | C6orf203_2 | 6_107044172_C_T / 6_107051038_GTTTTC_G | 0.005594780806642859 / 0.010350958813062314 | 1.8543097341742985e-05 / 4.7416804336943046e-05 |
| 625 | RIOK1_2 | 6_7390137_G_T / 6_7410502_GT_G | 0.0056620989198510035 / 0.009940460227242327 | 0.004558417307934729 / 0.0007644747214841657 |
| 626 | STX2_3 | 12_130796169_T_C / 12_130821769_C_G / 12_130827084_G_A | 0.0057763908603848755 / 0.0026232291323331123 / 0.0017127068028307182 | 0.03019238327054641 / 0.01065610617547119 / 0.004236660791662807 |
| 627 | DOCK9_6 | 13_98797273_A_G / 13_98888796_T_A / 13_98848509_C_T / 13_98902701_G_A / 13_98883901_TA_T / 13_98977850_C_T | 0.005927598026328671 / 1.199291147137571e-06 / 0.00025790841294325934 / 0.0030628908663900517 / 0.003688722979152048 / 1.1373148571396284e-05 | 0.006004783016582045 / 0.01781055671478815 / 0.005840989451706359 / 0.025244747630348088 / 0.020609371467392473 / 0.01526774575825921 |
| 628 | ADAM15_4 | 1_155056046_G_A / 1_155058081_A_C / 1_155058900_C_T / 1_155053372_T_G | 0.005983172351155387 / 0.003608774130493322 / 0.02011005006826893 / 0.013070176515727179 | 0.02587883400458268 / 0.038829781369162535 / 0.006114928575864872 / 0.005438593481843924 |
| 629 | ZNF430_3 | 19_21020746_C_T / 19_21033730_G_A / 19_21022725_C_T | 0.006039060973644978 / 0.0017404412233575466 / 0.0032443389741318627 | 0.0014493947676260713 / 3.875366882434858e-05 / 7.931044376997757e-06 |
| 630 | SLC41A2_2 | 12_104866497_A_G / 12_104805360_A_C | 0.006042414055759166 / 0.003878181222682689 | 0.04584324420776458 / 0.01814258498012539 |
| 631 | ARHGAP5_2 | 14_32092970_T_C / 14_32154828_T_C | 0.006122997092230283 / 0.00899034241039037 | 0.000109609141495362 / 0.0028505632724505807 |
| 632 | CTSB_5 | 8_11848168_C_G / 8_11853379_G_C / 8_11847933_G_T / 8_11852665_T_C / 8_11848361_G_A | 0.006170091093918575 / 0.013883502523880249 / 0.013105854756963943 / 9.23481096080534e-05 / 0.0030280965583678638 | 0.010885538500044391 / 0.006363373856765906 / 0.00949712914495799 / 0.00465817682934427 / 0.02101769256107376 |
| 633 | INTS10_7 | 8_19824136_G_A / 8_19825034_A_G / 8_19825081_A_G / 8_19832122_T_C / 8_19823225_T_C / 8_19823468_C_T / 8_19820404_G_A | 0.006249656348718163 / 9.755626466214517e-05 / 0.0032595992956769558 / 1.3994534854585697e-05 / 0.01825573585413804 / 0.0007017951945376175 / 0.0019656324021710553 | 0.004251571736144285 / 0.006724158153343274 / 0.02600076241538477 / 0.015595096037435119 / 0.0063513471360198154 / 0.004329630966639476 / 0.012844960200188478 |
| 634 | CHAF1A_3 | 19_4406163_G_A / 19_4442339_C_T / 19_4422720_A_G | 0.0064074940660708 / 3.653207387854824e-06 / 1.4819698101788669e-05 | 0.0008752119921859383 / 2.142565869765625e-07 / 0.024620616607439628 |
| 635 | MDC1_2 | 6_30711769_A_C / 6_30704316_T_G | 0.006463206071893797 / 0.0019882207404644673 | 0.0020262441930086923 / 0.0013599597266763966 |
| 636 | DYRK1A_3 | 21_37420484_TGGG_T / 21_37506256_A_C / 21_37505200_T_G | 0.006470184695707864 / 0.007166152604563953 / 0.0018009306683812387 | 0.004141112427822946 / 0.023367448843283026 / 0.006729513952629108 |
| 637 | SMPDL3B_2 | 1_27949055_T_G / 1_27956116_T_G | 0.00686332660241626 / 0.005864140422713154 | 0.0015905760666496795 / 0.0137996143213625 |
| 638 | EVPL_2 | 17_76023471_A_C / 17_76023459_T_G | 0.007000637494837062 / 0.0007672223327735785 | 0.005291001652021031 / 0.010508474240463184 |
| 639 | TOM1L1_5 | 17_54914767_TA_T / 17_54930294_T_G / 17_54936619_A_G / 17_54936871_A_ATTAAG / 17_54949462_TAAAAG_T | 0.007038383297527345 / 0.0050109411285773646 / 0.00021710780579647815 / 0.00028231096361921765 / 0.00012667235189768908 | 0.04878127910267323 / 0.03275406093703293 / 0.014250045450198362 / 0.01731618533169237 / 0.009468652758198769 |
| 640 | PPP6R2_6 | 22_50437806_T_C / 22_50444323_CT_C / 22_50438097_C_G / 22_50439767_G_A / 22_50444161_G_A / 22_50435068_C_T | 0.007051784222833177 / 0.023269327181446267 / 3.439001444964778e-05 / 7.581666224780631e-05 / 3.643039740627613e-05 / 0.0008291832461198612 | 0.0008491344323951777 / 6.519259302157606e-08 / 0.02539141451283096 / 0.0453099522882128 / 0.048741469250829166 / 0.04553862958411738 |
| 641 | DAB2IP_2 | 9_121772524_T_G / 9_121760326_A_C | 0.0070915742180131395 / 0.007778717869708281 | 0.02191587566106909 / 0.01751891495836218 |
| 642 | WRN_8 | 8_31096749_C_T / 8_31124455_G_T / 8_31141606_C_T / 8_31167122_C_T / 8_31068263_T_G / 8_31096728_GT_G / 8_31081188_G_A / 8_31154721_C_G | 0.0071839350828315045 / 1.9744778112725726e-06 / 3.7195190403966525e-05 / 0.0005948019596535545 / 1.4689350346055224e-05 / 0.009117602293234885 / 4.455137121499956e-06 / 0.015467137724934844 | 0.015593392890488516 / 0.0002318154176456728 / 0.000309347551379363 / 0.008293074145156037 / 0.01874901447901884 / 0.0010432049093381938 / 0.02919802325158393 / 0.008229549817641594 |
| 643 | SEC63_2 | 6_107876794_A_G / 6_107876670_C_A | 0.007209006342709896 / 0.0019416198580565237 | 0.0015670897229372802 / 0.02957724273333363 |
| 644 | MAU2_6 | 19_19336127_G_A / 19_19338794_G_A / 19_19338877_G_T / 19_19342712_T_G / 19_19342751_C_A / 19_19344019_G_A | 0.007212671514055286 / 0.000960361991019274 / 0.0009059794395416026 / 0.0008876467494768484 / 0.0008876467494768484 / 0.001002378802893851 | 3.528738486135461e-07 / 1.9278481053706903e-06 / 3.174590417336852e-07 / 1.942933711490239e-07 / 1.942933711490239e-07 / 3.6691446641905493e-07 |
| 645 | CDCP1_3 | 3_45091085_A_T / 3_45091145_T_C / 3_45095296_A_G | 0.007224118191596861 / 0.003521903825993761 / 7.820303910973087e-07 | 0.01528693636083844 / 0.0025128061409562703 / 0.034457598045182634 |
| 646 | NKTR_2 | 3_42630618_G_C / 3_42636885_C_A | 0.007397151891706983 / 0.004629789663279317 | 0.0027059941965995107 / 3.766470432445502e-05 |
| 647 | GSN_3 | 9_121321305_A_C / 9_121326911_A_C / 9_121282717_C_T | 0.00754758939906495 / 9.99197364773904e-05 / 0.008701863324990747 | 0.0036521684936499576 / 0.014858234163842209 / 0.04144642618836994 |
| 648 | MTR_3 | 1_236885200_A_G / 1_236897645_CT_C / 1_236812798_T_G | 0.007571674596968512 / 0.00019121697493807043 / 0.006559116282295972 | 0.013876029031175869 / 0.019195378846888603 / 0.028819324921187783 |
| 649 | DNAH1_4 | 3_52395506_T_G / 3_52398167_T_C / 3_52375405_A_G / 3_52394972_C_A | 0.007807586400497246 / 5.188940804112937e-07 / 0.028701683809333287 / 0.04830043674512241 | 0.020152041638368784 / 0.04601002692990365 / 0.006840623405991567 / 0.005200470677837818 |
| 650 | NDUFS7_6 | 19_1388539_C_T / 19_1389518_C_A / 19_1390758_C_A / 19_1391101_A_C / 19_1387920_T_G / 19_1387934_A_G | 0.007902298175424828 / 0.01802139597834927 / 0.005968824663343653 / 2.816150837753928e-07 / 0.0031818920109542336 / 0.02651542479567508 | 0.004445598304300863 / 0.004267266689815653 / 0.007929745168935362 / 0.02277060279294577 / 0.0061684138287453226 / 0.0002841985871883526 |
| 651 | TLN1_4 | 9_35711809_G_T / 9_35712826_G_A / 9_35700530_A_AGTTT / 9_35707057_C_T | 0.008212937465719947 / 4.3027034258145176e-05 / 6.892028990051384e-06 / 1.5583116688212289e-06 | 0.03705209858981909 / 0.019628446580987526 / 0.03215388610263167 / 0.026823292872806558 |
| 652 | PARPBP_3 | 12_102164766_G_C / 12_102165930_A_C / 12_102195841_T_TTAAAAA | 0.008239841603573375 / 0.048432585939195916 / 0.009577111829889028 | 9.259289657162176e-05 / 0.0008692851756599481 / 4.1069065265654646e-06 |
| 653 | FZD6_2 | 8_103300204_A_G / 8_103318860_G_C | 0.008531191339496548 / 0.00031326302687667253 | 0.02679919317294273 / 0.01810032651868897 |
| 654 | ITPR1_10 | 3_4651972_C_T / 3_4673329_A_C / 3_4712028_A_G / 3_4814550_G_A / 3_4645814_T_A / 3_4652327_G_A / 3_4653996_G_A / 3_4717319_C_T / 3_4652159_T_G / 3_4516699_C_T | 0.00859416859519535 / 0.0036591352908788796 / 0.002472562485621646 / 0.0007540687837519184 / 1.174056333280529e-06 / 1.6973582056331476e-05 / 0.00018073915749960563 / 0.025102582779245618 / 0.0060202139881954326 / 0.01485572695651343 | 0.02221500748211688 / 0.028276024726866744 / 0.031417032356405285 / 0.020003750528966732 / 0.02165052204755015 / 0.04826424992681114 / 0.04219875731949733 / 0.00956347809995603 / 0.032544122080128725 / 0.04748127629652489 |
| 655 | LAMA5_11 | 20_62307035_T_C / 20_62308863_T_C / 20_62315711_A_C / 20_62325178_T_C / 20_62327158_G_A / 20_62327540_T_G / 20_62310033_T_G / 20_62327738_A_C / 20_62332572_T_G / 20_62327734_A_C / 20_62345568_A_G | 0.008632920752406494 / 0.014295751572041776 / 0.02909024968748458 / 3.555862255130917e-08 / 2.9240346346210547e-06 / 0.00712140384613043 / 1.5666190990300454e-05 / 0.019613193736301028 / 0.03355260503997278 / 0.034148373295335904 / 1.0743773421509558e-05 | 0.008839994985818419 / 0.003401604212977075 / 0.0003409731985327621 / 0.010970601799299722 / 0.037454561614064526 / 0.04839717926265442 / 0.00011553533752570969 / 0.00016041497097470358 / 0.00634985461358608 / 0.00014957483336764524 / 0.02125937044218393 |
| 656 | MAPRE2_2 | 18_35132001_G_GT / 18_35070377_A_G | 0.008697538540744818 / 0.0008936827603968188 | 0.027950082818089944 / 0.013874344261478143 |
| 657 | PCM1_14 | 8_17938873_A_G / 8_17938874_C_T / 8_17947156_G_A / 8_17957171_G_C / 8_17962063_C_T / 8_17962252_A_G / 8_17972247_C_CAA / 8_17993739_C_A / 8_18010736_C_A / 8_18014089_T_A / 8_18014110_A_C / 8_18027462_G_A / 8_18027582_T_C / 8_17963329_A_C | 0.008797381653836422 / 0.008797381653836422 / 8.592105380343799e-09 / 9.956680768337928e-13 / 6.195811157969624e-08 / 1.8937727055349602e-07 / 0.012906783621554044 / 0.00024859599240286334 / 0.0005752822575338514 / 1.5559989504674227e-05 / 2.7991275648315256e-08 / 1.0617795138512517e-06 / 1.3096196909220091e-08 / 0.013270249004941498 | 0.0286880097933444 / 0.0286880097933444 / 0.005755604603604279 / 0.003664181277087841 / 0.003941798080137453 / 0.000146676782393952 / 0.003377252281952908 / 0.0004892784845984415 / 0.01725609483145887 / 0.00016889400218637822 / 0.0005696202104790463 / 5.9466930864771254e-05 / 0.0032089265919612235 / 0.004113314671783447 |
| 658 | LAMC2_2 | 1_183207851_G_T / 1_183207864_G_T | 0.0090311817049441 / 0.0010913836051824374 | 0.02500420336879176 / 0.034260068788679536 |
| 659 | FAT1_2 | 4_186706505_TAAAAAA_T / 4_186628213_A_C | 0.009108698459398929 / 0.008101657943453211 | 0.02585265305545377 / 0.01860566173117391 |
| 660 | SQSTM1_3 | 5_179833009_G_A / 5_179822433_T_C / 5_179832842_G_C | 0.0096926694417795 / 0.004856219591816439 / 0.0277352874184494 | 0.03979973429187952 / 0.0024949336391905503 / 0.0024314650981475784 |
| 661 | CCDC25_3 | 8_27736133_T_C / 8_27740525_GA_G / 8_27740655_A_G | 0.009721303652590912 / 0.0012870249285031976 / 0.019736174159448082 | 0.012214514779241077 / 3.013644227200994e-08 / 0.009242113446549792 |
| 662 | PTGFRN_2 | 1_116949272_C_G / 1_116985006_T_C | 0.009786238032301352 / 0.0007152254747991232 | 0.04386987327886 / 0.015007302908998025 |
| 663 | CUEDC1_2 | 17_57872703_C_T / 17_57873465_G_A | 0.010263213673294223 / 0.0029406902030506186 | 0.0013582824059236026 / 0.00965828204249475 |
| 664 | POLR3D_5 | 8_22247989_T_C / 8_22247116_G_A / 8_22247770_T_C / 8_22250473_A_G / 8_22245170_T_G | 0.010361813952662016 / 0.040760845043798406 / 0.010265363996485286 / 0.010265363996485286 / 0.03202227743017228 | 0.0015081231813274575 / 0.0005996811951877831 / 0.0014851724380103976 / 0.0014851724380103976 / 0.0034846025589736784 |
| 665 | MDN1_10 | 6_89661483_G_A / 6_89662267_C_T / 6_89680724_C_A / 6_89712908_G_C / 6_89728912_G_T / 6_89745710_T_C / 6_89819438_A_G / 6_89819440_C_G / 6_89819446_A_G / 6_89656810_T_C | 0.011142557737209857 / 0.019733545814518076 / 0.00671054318104286 / 0.009319633314546674 / 0.029067614736169964 / 0.014718502010945343 / 0.03726926768860217 / 4.658109373380921e-05 / 0.00043794075690144836 / 0.001077236984005633 | 8.702195141061847e-05 / 4.241840867716095e-05 / 3.792323014139115e-05 / 0.002381685713249437 / 0.003051989681616468 / 0.0024784505977437274 / 0.002315253787970113 / 0.00030565312846269634 / 0.0005358395597195241 / 0.045388379703494304 |
| 666 | ZNF407_5 | 18_74635526_T_C / 18_74881076_C_G / 18_74881080_A_C / 18_75064165_G_A / 18_74881141_G_A | 0.01132130975657727 / 0.03691411059827635 / 0.002564188916256107 / 0.00027018930993972406 / 0.0024107982547803396 | 0.0030145474545959137 / 0.009890224680183182 / 0.03975077518004473 / 0.0037574487440396095 / 0.018926593122392126 |
| 667 | C18orf21_2 | 18_35977490_T_C / 18_35973023_A_G | 0.011570265284110644 / 0.04350573719131977 | 8.814319140246499e-05 / 0.009001638536085271 |
| 668 | DNHD1_2 | 11_6566998_G_A / 11_6502909_T_C | 0.01157615377505105 / 0.024706472106323003 | 0.003441011845932656 / 0.0051368432267910715 |
| 669 | KCNQ5_2 | 6_72622312_C_G / 6_73194868_A_C | 0.011667048329227513 / 0.008556892857902195 | 0.005821769162034106 / 0.002035847347947271 |
| 670 | USP7_3 | 16_8916969_T_TA / 16_8921401_T_C / 16_8919178_A_G | 0.011921515809972538 / 0.0007259106255980508 / 0.00985787434616614 | 0.007935686984078177 / 0.03489258945527392 / 0.01271404693174776 |
| 671 | KRT19_2 | 17_41524128_T_G / 17_41524420_C_T | 0.012145831162385651 / 0.02329208372328466 | 0.006794604788851329 / 0.0075159453943370955 |
| 672 | CHD4_2 | 12_6598281_A_C / 12_6596093_T_C | 0.0122076861217219 / 0.004382346617449564 | 0.0023450404288739924 / 0.005341196474657028 |
| 673 | TRIO_5 | 5_14270972_A_C / 5_14380924_T_A / 5_14287139_AT_A / 5_14485052_GTTTT_G / 5_14304660_GA_G | 0.01228372579415868 / 3.324291735916414e-05 / 0.01866091088461598 / 0.0021188750196952637 / 0.001000539371629746 | 0.0041763005884629285 / 0.009266068007448034 / 4.1269944199248776e-05 / 0.00011802420018250479 / 0.0066869864395857175 |
| 674 | NR2F6_3 | 19_17232488_A_G / 19_17240807_T_C / 19_17240813_T_C | 0.012426826069594731 / 0.008405600723765323 / 0.0104569397340928 | 0.0005711072972571918 / 0.006907234943082266 / 1.728226736131038e-05 |
| 675 | HNRNPH1_2 | 5_179621204_T_C / 5_179614784_GAAAAA_G | 0.012466319116509934 / 0.03611121611218025 | 0.0008981889773064157 / 0.009729395921872941 |
| 676 | POLDIP3_2 | 22_42585672_T_C / 22_42585502_A_C | 0.012811765150489051 / 0.04394982419601543 | 3.6252104008481515e-06 / 0.004353728585767742 |
| 677 | CASKIN2_4 | 17_75501358_G_A / 17_75501713_T_C / 17_75503616_T_C / 17_75508335_T_C | 0.01313679969802845 / 0.0005650477736965628 / 0.0014275310574789414 / 0.004128633364054907 | 0.002427426610400476 / 0.00023272703416067725 / 0.00689117538932749 / 0.024705224854909082 |
| 678 | ZNF557_3 | 19_7083618_A_G / 19_7083750_A_G / 19_7074861_G_A | 0.014332802500416091 / 0.016198364111666076 / 0.009991664044269358 | 1.6329734686551152e-07 / 4.640996358288638e-07 / 0.019872633283012617 |
| 679 | BPTF_2 | 17_67825365_C_T / 17_67911547_C_G | 0.01437455334956587 / 0.027807620738219758 | 2.5754103071800682e-05 / 0.006958200054189394 |
| 680 | UGGT2_3 | 13_95833163_A_G / 13_95853698_T_C / 13_95860933_T_C | 0.015116310313098947 / 0.037400522782126695 / 0.007496186466991611 | 0.000224596103770692 / 0.0011686091908779301 / 0.002068524896740717 |
| 681 | FNDC3B_3 | 3_172362611_AT_A / 3_172328905_GT_G / 3_172286041_CTTTT_C | 0.015509630370521969 / 0.002266663581871069 / 0.0003779941256659541 | 0.0007669696976411361 / 1.7757436099968484e-05 / 0.031871180713847265 |
| 682 | CLIP1_3 | 12_122328152_A_C / 12_122328157_C_T / 12_122328162_C_T | 0.01554438347868009 / 0.004768276278894758 / 0.002667521200669866 | 0.002481037749459045 / 0.041472618812521435 / 0.048511002649469816 |
| 683 | TNKS_6 | 8_9680125_G_A / 8_9720284_A_AT / 8_9720294_C_A / 8_9735571_A_C / 8_9751720_A_C / 8_9766458_A_C | 0.015553063070783985 / 0.021640953132470588 / 0.009525586921605824 / 0.006640140033620625 / 0.006977786341777385 / 0.032727629530903864 | 1.1196019412041484e-09 / 6.428366457977679e-07 / 9.234432766615335e-08 / 4.809045747636942e-06 / 0.019396751254115357 / 9.650265166072016e-07 |
| 684 | NAA15_2 | 4_139349721_G_A / 4_139349435_AT_A | 0.01573160679440035 / 0.003429044586968857 | 0.0002098904518747522 / 0.002911064627846368 |
| 685 | RANBP3_5 | 19_5928023_T_G / 19_5928174_T_C / 19_5915583_A_G / 19_5925847_A_C / 19_5978199_C_T | 0.01583040778996785 / 4.474815722770587e-05 / 5.7769976083466666e-05 / 0.0026896515436457035 / 0.007526230369901563 | 0.009045897483820205 / 0.0004179910655369823 / 0.03657225828634877 / 0.013386174688145538 / 0.043887995871297616 |
| 686 | CCP110_6 | 16_19536035_A_G / 16_19536181_C_T / 16_19545945_C_T / 16_19541861_T_C / 16_19536052_C_A / 16_19548016_T_G | 0.016159655378318708 / 0.04502177918333454 / 0.008022125809200288 / 4.851993209582035e-06 / 0.0004153878057481152 / 0.025513237898367132 | 0.00016378049017362915 / 0.0005567133937571787 / 0.0006179187799490345 / 0.015929257083152543 / 0.0007996357401027085 / 0.009536820248258198 |
| 687 | ANXA11_2 | 10_80166029_C_T / 10_80161797_T_C | 0.016605419991514502 / 0.0051164435438795204 | 0.007800123858178394 / 0.0013053025194313356 |
| 688 | PLEC_5 | 8_143935900_T_G / 8_143916360_A_G / 8_143918739_A_C / 8_143929244_A_C / 8_143934289_T_G | 0.01665471808934805 / 0.0034243187807631525 / 0.0018067465091272969 / 0.0008521926558447601 / 0.0001319263889148404 | 0.0004960012901022363 / 0.00910116635228719 / 2.138708286444241e-05 / 0.04249632659180479 / 0.008202162742211878 |
| 689 | PDHB_5 | 3_58429863_C_A / 3_58427942_G_T / 3_58430808_C_T / 3_58431043_T_TTTA / 3_58431689_C_T | 0.016694590509161198 / 0.0034915452482365546 / 0.0014468501934601355 / 0.00012132584593612988 / 0.0014468501934601355 | 1.9636106867401007e-06 / 9.607912469556515e-06 / 1.1215690852590127e-06 / 4.480434017438887e-06 / 1.1215690852590127e-06 |
| 690 | ABHD12_3 | 20_25307869_C_T / 20_25297964_G_A / 20_25301097_T_C | 0.017594886478281925 / 0.043687457267011516 / 0.004129132243776882 | 8.56668297363822e-06 / 0.00227969505884927 / 0.0004270759204191932 |
| 691 | TRAPPC8_10 | 18_31858057_A_C / 18_31913653_A_G / 18_31900873_G_A / 18_31900876_C_A / 18_31867505_T_G / 18_31907633_T_A / 18_31846589_A_C / 18_31871211_T_A / 18_31901115_GT_G / 18_31858058_CT_C | 0.01811627325789324 / 0.0017149077087971164 / 0.007882909715425471 / 0.0003097530865800165 / 0.0017696529343949547 / 0.003408008625421304 / 0.0025767772792916893 / 0.020052128513604172 / 0.0014872998913138286 / 0.009626844127190594 | 0.006180390175955454 / 0.009898646981541573 / 3.5402082656175115e-05 / 2.004341589623153e-05 / 0.00036773660587014015 / 0.0008596942505949141 / 0.0019258630221215085 / 0.0005317253240119541 / 0.03754796616685669 / 0.003048367023556882 |
| 692 | NARF_2 | 17_82488071_A_G / 17_82485433_G_A | 0.018611831902577654 / 0.0032741374426950077 | 0.0015678226483248074 / 0.03776328708562675 |
| 693 | RPL9_3 | 4_39454772_G_A / 4_39458104_T_C / 4_39457622_A_G | 0.01872028096022281 / 0.038040018913816906 / 0.013766563241610607 | 0.004161577416808298 / 0.004570198384291764 / 4.793806278603332e-07 |
| 694 | SENP7_2 | 3_101347873_T_A / 3_101513249_C_A | 0.01892010828896953 / 0.027162288974149237 | 4.432034386075619e-05 / 0.00843965290168897 |
| 695 | HERC1_4 | 15_63666001_A_C / 15_63666004_T_C / 15_63754569_A_C / 15_63706823_T_C | 0.018947416114520832 / 0.012801946597404643 / 0.009094911651776984 / 0.0001905333488051304 | 0.0009552551098417773 / 0.0050390069990103115 / 0.007343118479360836 / 0.005050957906342418 |
| 696 | DOCK11_2 | X_118627539_A_C / X_118580020_T_G | 0.019238892996198773 / 0.002446966159681028 | 0.00012436903410890539 / 0.02379391735060052 |
| 697 | KLF5_3 | 13_73063987_G_T / 13_73062772_A_AGTGT / 13_73063986_TG_T | 0.019354403860496208 / 0.037567154465037694 / 0.006314572274949971 | 0.008502737493358522 / 0.0008455054702052634 / 0.045197394376435635 |
| 698 | FERMT1_2 | 20_6119441_A_G / 20_6076305_T_G | 0.01953104506649206 / 1.5328575507414378e-05 | 0.003951008923557318 / 0.005589077504505465 |
| 699 | CGGBP1_2 | 3_88056114_A_C / 3_88058700_T_G | 0.019690640293771062 / 0.0001488078729312028 | 0.0013325718879930134 / 7.124415972693971e-06 |
| 700 | CEP85L_4 | 6_118511157_T_C / 6_118565452_T_C / 6_118565798_G_T / 6_118652790_A_G | 0.019951442705337254 / 3.4006295145334306e-05 / 0.006640489210238536 / 0.005690521125333515 | 0.0019936945989450267 / 0.031500707148776626 / 0.011376444437361329 / 0.01248838915032558 |
| 701 | TCF4_7 | 18_55585157_G_A / 18_55464257_C_A / 18_55463971_TGTGTGTGA_T / 18_55275657_A_G / 18_55403517_A_C / 18_55461237_G_T / 18_55234488_T_G | 0.02005132938992895 / 9.139603483849228e-07 / 0.003907248287482544 / 0.04979553061082194 / 0.027277557605803925 / 0.004036463102105114 / 0.0005592100190603741 | 0.002362550141751555 / 0.032420073593804284 / 0.03333184670009802 / 0.0013930308437610063 / 1.5397131093463103e-06 / 0.04572000946513434 / 0.005926553123167896 |
| 702 | DQX1_2 | 2_74518953_C_T / 2_74519195_A_T | 0.02016550460713128 / 0.02345411840768387 | 0.001543466936969916 / 0.0012259823356569838 |
| 703 | UBR5_3 | 8_102327653_A_C / 8_102288240_T_C / 8_102311353_A_G | 0.02158342295983112 / 0.000182245886028422 / 0.002891650419980013 | 0.0014448817758050778 / 0.041616237854309936 / 0.00926532742682097 |
| 704 | UBR7_2 | 14_93227076_C_T / 14_93227060_C_A | 0.021764228343538142 / 0.00036547494521639036 | 5.580051554471299e-12 / 0.004489348973894868 |
| 705 | PRDM15_6 | 21_41804523_A_G / 21_41857170_C_CT / 21_41878737_C_T / 21_41878845_C_CG / 21_41879218_C_A / 21_41860296_C_G | 0.022209828018085867 / 0.0016831430872538335 / 0.001963497325920565 / 4.181886700329235e-07 / 0.0008539747138144563 / 0.003762939149636617 | 0.0024789131706555692 / 0.04559041805735448 / 0.004333100546220035 / 0.0014981405701937028 / 0.007033127481264185 / 0.003918924565748825 |
| 706 | HPS4_3 | 22_26464303_G_C / 22_26466187_C_A / 22_26466246_T_C | 0.023338960947810374 / 0.0034082024391394804 / 0.008599880725164986 | 0.00049975228288003 / 0.013660798942983977 / 0.013660798942983977 |
| 707 | KIF13A_2 | 6_17759921_G_T / 6_17779691_GA_G | 0.02351576585497226 / 0.0016700241845674759 | 0.005082432403932738 / 0.03874282920193672 |
| 708 | SLC35B4_8 | 7_134294793_A_T / 7_134294800_C_T / 7_134294826_A_G / 7_134295043_T_C / 7_134296475_G_A / 7_134299375_A_G / 7_134300126_G_A / 7_134304791_A_G | 0.02373113198705864 / 0.01698627709999008 / 0.006372984518535906 / 0.02196618128109366 / 0.0003440877501955943 / 0.006567115319239084 / 3.4006295145334306e-05 / 0.005046500727253695 | 0.007700956159853255 / 0.0033988992551489622 / 0.003846947305778054 / 0.003846947305778054 / 0.0005322435434420271 / 0.004732359355015072 / 0.00026123770283039777 / 0.0007109966209961128 |
| 709 | L3MBTL2_6 | 22_41213686_C_T / 22_41221314_G_C / 22_41217184_C_T / 22_41217299_C_T / 22_41221156_T_TG / 22_41214238_A_G | 0.02384699817673188 / 0.036506965435244586 / 0.00046243520821700383 / 0.0014542660494230402 / 0.0048712846790899276 / 0.009223190722677185 | 0.0010787186334203051 / 0.0001832674707524145 / 0.0038205423576211455 / 0.004209694792725524 / 4.2157738222413464e-06 / 0.04965109007915304 |
| 710 | RAI14_6 | 5_34810866_G_A / 5_34811689_T_C / 5_34812303_A_G / 5_34812384_A_G / 5_34814795_A_G / 5_34826376_A_C | 0.02398248389974741 / 0.003021738485801497 / 0.03016889098915158 / 0.04699754955019005 / 0.007276272312251042 / 0.03015590631046501 | 0.005930385895234786 / 0.02067007422009637 / 0.008963944637711066 / 0.0075054618188784596 / 0.002646842318515723 / 0.006485048570616563 |
| 711 | ARHGEF10L_2 | 1_17632421_T_G / 1_17581112_C_T | 0.02441616386812752 / 0.008405600723765323 | 0.00740919250255517 / 0.019746113249432044 |
| 712 | WFS1_2 | 4_6300580_T_G / 4_6301666_T_G | 0.024665242803626187 / 0.008957131401361508 | 0.0005139212842413073 / 0.005931412638336574 |
| 713 | TPP2_5 | 13_102645085_CT_C / 13_102649187_G_T / 13_102629949_C_G / 13_102634223_C_T / 13_102645085_CTT_C | 0.024741402723073853 / 0.028415295283801194 / 0.001061432461116305 / 0.03296472481201721 / 0.00032041277623460525 | 0.0017617933204615989 / 0.0003388682906380855 / 2.491492385425685e-05 / 0.0010859815068279958 / 0.04128722708381896 |
| 714 | DPY19L3_3 | 19_32480317_C_T / 19_32482171_C_T / 19_32457979_A_AT | 0.02575962131883935 / 0.041529928834727996 / 8.068330723796263e-08 | 0.00488668851811109 / 0.00656763144792808 / 0.0003669711749463792 |
| 715 | SYNE1_13 | 6_152149487_A_G / 6_152310394_A_C / 6_152302141_A_G / 6_152350340_A_C / 6_152350418_A_G / 6_152350784_G_GA / 6_152350840_A_G / 6_152354719_A_G / 6_152373049_T_C / 6_152416413_T_G / 6_152352408_C_CT / 6_152326359_G_A / 6_152167902_T_G | 0.02589202251594358 / 0.0068225672761204 / 0.018111885168250186 / 0.001534088782688901 / 0.00015349542079229654 / 0.003947934300958396 / 0.009039115199453142 / 0.0032281218393380826 / 0.034085027891066176 / 0.0074217808535962425 / 0.0003084243419514754 / 0.04013949097321684 / 0.007925318609942202 | 0.0022312687521415984 / 0.000300569048618415 / 0.000916091757381376 / 0.04334315784101184 / 0.025133645776259043 / 0.015037738599618973 / 0.049886685026608805 / 0.04777964311542563 / 0.003302156741579197 / 0.012499408296212235 / 0.002950466518563949 / 0.002843434249435789 / 0.025194372743123864 |
| 716 | BAIAP2L1_2 | 7_98312162_T_G / 7_98310492_T_G | 0.02645273506751201 / 0.017881464475754172 | 0.002108350377110309 / 3.1631490207583316e-05 |
| 717 | CXXC1_4 | 18_50283881_C_G / 18_50283981_A_G / 18_50282775_A_C / 18_50285505_A_G | 0.02700492420991353 / 0.00030830634455756233 / 0.00020363998830215009 / 0.024668590953954232 | 0.0054045514118498715 / 0.0069760254674185035 / 0.00041677651706905364 / 1.2396826716404366e-06 |
| 718 | ITGB5_3 | 3_124769064_T_G / 3_124796789_C_T / 3_124809087_T_G | 0.027271474201973192 / 0.0030628908663900517 / 0.02459057498205289 | 0.0006588536356118503 / 0.03655295537599197 / 5.4585187494895796e-05 |
| 719 | BRD4_2 | 19_15255220_T_G / 19_15264730_T_G | 0.02738257500091704 / 0.0024688743871748233 | 0.003128882089479218 / 0.012931811845921107 |
| 720 | TUBGCP6_3 | 22_50218683_C_T / 22_50226183_A_G / 22_50216669_A_G | 0.02873848846989375 / 1.7193787546395546e-05 / 0.001425645880342349 | 0.0032493001194240914 / 0.004608803965780261 / 0.0053976890998902035 |
| 721 | SH2D4A_2 | 8_19373444_G_GTA / 8_19373444_G_A | 0.029078590360841292 / 0.0012205889084294006 | 0.0029847738366696104 / 0.03439931765423256 |
| 722 | UPP1_3 | 7_48088999_G_A / 7_48108129_C_G / 7_48108147_T_G | 0.029144965782620207 / 0.015833254501378846 / 0.01682115524692246 | 0.0003765748447247093 / 0.0002337913556195707 / 0.0015081620173450355 |
| 723 | WDR48_5 | 3_39068755_C_T / 3_39069649_C_A / 3_39066494_T_A / 3_39077046_G_A / 3_39052175_T_A | 0.030420442989910295 / 0.044145461001922535 / 5.492585713676155e-05 / 0.00014207366024108895 / 0.015418219237359813 | 0.00013091692663621323 / 1.1291180538837308e-09 / 0.030704581537927867 / 0.04365312343408456 / 0.002516254064872987 |
| 724 | PDS5B_5 | 13_32741072_A_T / 13_32758091_C_T / 13_32675925_C_A / 13_32710010_G_T / 13_32652145_GT_G | 0.030726392282429425 / 0.00123879071402958 / 0.0006856670147522433 / 0.002121608222392312 / 0.0007921211551638221 | 0.001639201016530517 / 0.0023301391981286807 / 0.004241708828197667 / 0.017388913859398773 / 0.002787725341881676 |
| 725 | AHNAK2_13 | 14_104948863_G_C / 14_104950348_C_G / 14_104952007_T_G / 14_104952054_C_T / 14_104954590_A_G / 14_104955559_A_C / 14_104949306_T_C / 14_104950948_C_T / 14_104946565_A_C / 14_104949318_G_C / 14_104953856_A_C / 14_104944923_A_G / 14_104945888_T_G | 0.0308328381135858 / 0.016748316074642184 / 0.03839823545317707 / 0.03874915731384604 / 0.0072096008154851265 / 1.5768275144985015e-05 / 0.006402387188591212 / 0.006209224175079767 / 0.02197650841839336 / 0.005813098445302893 / 0.024214266407806717 / 0.0185888935199706 / 0.0006623043768660483 | 0.0037872773041585602 / 0.0010008042001551844 / 4.242877237542688e-05 / 4.758634079373864e-05 / 0.044213954062984784 / 0.00506490504122054 / 0.005256944789299486 / 0.009057439080581924 / 0.006657596405885244 / 0.015474300784924832 / 0.003500316527332319 / 0.004782218518041667 / 0.009471254952683202 |
| 726 | PSIP1_4 | 9_15469426_TA_T / 9_15472613_GA_G / 9_15478664_T_C / 9_15473904_C_CA | 0.03090002089985741 / 0.010885733995064931 / 0.0036412739882121493 / 0.019522544533840024 | 0.0021167351616768765 / 0.002781333210996778 / 0.04454350703768868 / 0.047598542315053116 |
| 727 | ANK3_2 | 10_60140286_C_G / 10_60140292_G_T | 0.031415751059474716 / 0.004915637551152243 | 0.006334167714527676 / 0.025015110862319518 |
| 728 | PLEK_3 | 2_68380987_A_C / 2_68388306_A_G / 2_68380161_C_G | 0.0317726416239668 / 0.008640427676032429 / 0.003025481684231003 | 0.0018651167043750433 / 0.012112306050675708 / 0.004442991541746456 |
| 729 | HMGB1_2 | 13_30463652_C_G / 13_30465849_T_C | 0.03226480417721332 / 0.0001648093940653516 | 0.0005823170484383475 / 1.5385023502599213e-07 |
| 730 | ACTN1_2 | 14_68890121_A_G / 14_68904620_A_G | 0.032894585296185316 / 0.002540635063275344 | 0.0030504600602986385 / 0.01924890787722053 |
| 731 | FAM193A_2 | 4_2662705_A_G / 4_2659865_A_C | 0.033419216681695084 / 0.04113816735227994 | 0.006119225115333783 / 0.002421422710409682 |
| 732 | ALS2CL_3 | 3_46688267_C_G / 3_46671861_C_A / 3_46683906_C_A | 0.03379224538431711 / 2.315014453759593e-05 / 0.005940717099935289 | 0.0010458636942191153 / 0.016517080453509674 / 0.048512125386189216 |
| 733 | SMARCA5_3 | 4_143521582_C_T / 4_143514027_G_A / 4_143513907_T_G | 0.03389913212461259 / 0.0005336701932334038 / 0.00047650766195259835 | 0.009752627346239709 / 0.0006586181076668231 / 0.004556295949163353 |
| 734 | TMBIM1_4 | 2_218278506_G_A / 2_218278604_T_C / 2_218279426_G_A / 2_218282145_T_C | 0.03396031249525595 / 0.02844679337110864 / 0.0068961961974542295 / 0.0018492744109954121 | 0.002273449490648745 / 0.0012042001777173455 / 0.0022480783740468167 / 0.030530266212098117 |
| 735 | ZNF236_5 | 18_76959812_T_C / 18_76968158_T_C / 18_76968252_C_T / 18_76936580_G_T / 18_76968514_A_G | 0.034863364756142684 / 0.00544264119615534 / 0.007385442293655849 / 1.258127500782992e-05 / 0.001396157570840323 | 0.004671655781344212 / 3.359123080186937e-06 / 3.816383122507129e-05 / 2.2508576141383803e-05 / 0.00014020410621502926 |
| 736 | DMAP1_3 | 1_44213884_A_G / 1_44219323_T_C / 1_44214487_A_C | 0.03508585380179657 / 0.0001543183975019544 / 0.000996146741984629 | 2.797176359518221e-05 / 0.04898236049763705 / 0.041077293102317024 |
| 737 | GIT2_2 | 12_109951210_A_C / 12_109952676_A_C | 0.038020170939281527 / 0.044654978525331915 | 0.0015711134341594402 / 0.0073535263645836966 |
| 738 | PBRM1_4 | 3_52642049_CA_C / 3_52642048_AC_A / 3_52642050_A_T / 3_52658412_CTT_C | 0.03826328245790342 / 0.003417708183485354 / 0.003417708183485354 / 0.004371631368875628 | 0.0014123627803440367 / 0.00010786476378721626 / 0.00010786476378721626 / 0.04797045127180218 |
| 739 | SEMA4B_3 | 15_90230550_C_T / 15_90219735_T_G / 15_90223369_T_C | 0.0382907038385724 / 0.00014017436078508742 / 0.003606528003523896 | 0.003576989974401659 / 0.0196110620734337 / 0.012423711849739305 |
| 740 | CDH1_2 | 16_68823310_T_G / 16_68810107_C_G | 0.03866739925480673 / 2.3568872507011226e-05 | 0.0025541666878341144 / 0.0045199561560194616 |
| 741 | PAK4_3 | 19_39176740_T_C / 19_39178411_T_C / 19_39178960_A_ATG | 0.03964657176847531 / 0.0031968419187330646 / 0.00031366512220605466 | 0.0005253339462112416 / 0.012050619287225093 / 0.04112372072532399 |
| 742 | KDM5A_2 | 12_310904_G_A / 12_323658_C_A | 0.040083104628847975 / 0.03485434053230182 | 8.99232571405919e-08 / 4.775460326696479e-06 |
| 743 | CHMP7_4 | 8_23249152_A_G / 8_23260130_T_C / 8_23260642_T_C / 8_23255149_C_T | 0.040858161657175214 / 0.0021955959993491484 / 0.001347026932454516 / 0.005979199546716722 | 0.00985156252549634 / 0.007951126415472621 / 0.005852678740537498 / 2.528028640474925e-05 |
| 744 | FASTKD1_2 | 2_169557305_CA_C / 2_169557305_CAA_C | 0.04142328785089491 / 0.016746895905411573 | 0.00016945881737810868 / 0.003864236188058555 |
| 745 | MRPL39_5 | 21_25587877_T_G / 21_25588774_T_C / 21_25594005_A_G / 21_25603938_A_G / 21_25607316_G_A | 0.04194490101459973 / 0.01937493996228174 / 0.01845646940649424 / 0.02800309093409305 / 0.00630118834188515 | 5.7418126731545284e-08 / 3.6929628125728576e-08 / 2.5701269842959545e-08 / 1.0577675519010665e-08 / 3.688861166466308e-08 |
| 746 | PON2_2 | 7_95406313_A_C / 7_95406317_T_C | 0.04295809677939748 / 0.03518057074232925 | 9.367508145310504e-06 / 9.041805671182428e-07 |
| 747 | ATP9A_2 | 20_51608625_A_C / 20_51627544_T_G | 0.0453107586125816 / 0.0033064577154371753 | 0.0016205979394364285 / 0.046011362965187 |
| 748 | SYNE2_3 | 14_64189964_AT_A / 14_64022731_CT_C / 14_64122119_G_A | 0.04554515566635235 / 0.0259958042872378 / 0.005029743152006167 | 6.34029580306576e-05 / 0.003556496243260812 / 0.031891035954103614 |
| 749 | EXD2_2 | 14_69236592_C_T / 14_69236597_G_T | 0.045815872520569866 / 0.007261223228798206 | 0.006743325380355538 / 0.009984452523516405 |
| 750 | USP22_9 | 17_21002832_G_C / 17_21002938_C_T / 17_21002944_A_G / 17_21005012_T_C / 17_21018179_C_T / 17_21021210_G_A / 17_21021307_T_C / 17_21028347_G_T / 17_21043080_T_C | 0.04602479247359704 / 0.008276359973551 / 0.0003145539245206166 / 0.00013159988064048868 / 0.00017641068386537028 / 0.00018037842009303046 / 0.002766843921558569 / 0.00965100020152009 / 0.0021915580128042123 | 5.2405530742318296e-05 / 0.0001522332352001979 / 0.0010200867803667195 / 0.0002608036035294038 / 0.0002258154609608441 / 0.00012857609143244398 / 4.777859944106238e-06 / 0.001140393407840919 / 0.01642994041963463 |
| 751 | R3HDM1_2 | 2_135621624_GT_G / 2_135661361_A_C | 0.04643229751040803 / 0.01096218490346052 | 0.007933574405897037 / 0.00075038338644858 |
| 752 | LAIR1_2 | 19_54364274_T_C / 19_54364717_T_C | 0.04672350230262375 / 0.015465209925053043 | 0.008257714587898193 / 0.006617848488520711 |
| 753 | EVL_5 | 14_100126634_T_G / 14_100132827_G_A / 14_100126622_G_A / 14_100132645_T_G / 14_100135917_A_C | 0.047372429474904484 / 0.0016660544745078804 / 0.004134369004838065 / 0.00016640135361204822 / 0.0031029134247096963 | 4.756430435799507e-06 / 0.00563219201718044 / 0.01997007957497231 / 0.026704266687616097 / 0.006469582595095918 |
| 754 | RNF123_2 | 3_49714152_C_T / 3_49700145_G_T | 0.047756940070976237 / 1.1366734297895966e-06 | 0.00816572334990732 / 0.0037608177292696564 |
| 755 | DNMT1_2 | 19_10162649_G_A / 19_10143809_G_C | 0.04804143143713783 / 0.022663915935835485 | 0.0013474327860987167 / 0.0054179883970128856 |
| 756 | BTBD16_4 | 10_122275013_G_T / 10_122275188_T_C / 10_122285973_C_T / 10_122291060_G_A | 0.04876523124872777 / 0.04476796806488366 / 0.00874169822078938 / 0.03049550442980961 | 0.0003520007001970831 / 0.00020893956494733148 / 0.0013169765604353282 / 0.0026073441109972398 |
| 757 | FUCA2_2 | 6_143504166_C_A / 6_143507227_A_G | 0.049200639651661375 / 0.029895339238934462 | 0.00639339868461808 / 0.0054745403112583324 |
| 758 | PPIP5K2_3 | 5_103201499_T_G / 5_103201584_A_G / 5_103201656_T_C | 0.04957254295359858 / 0.00015517194478671765 / 9.016600091479696e-05 | 0.00015030812167049831 / 0.020151832289907558 / 0.029631285544831236 |
| 759 | TIMM44_3 | 19_7932571_A_G / 19_7932574_T_G / 19_7932577_T_G | 1.3167297251695571e-05 / 0.0003422957438462025 / 0.0005904858316322034 | 0.02845639919448445 / 0.006688970144575634 / 0.006057634937627619 |
| 760 | MEX3C_2 | 18_51196847_C_T / 18_51196775_CGCCGCCGCG_C | 1.329885109524148e-10 / 0.0022225090338153708 | 5.249784413332885e-07 / 0.01963887463995091 |
| 761 | MTUS1_3 | 8_17754377_G_A / 8_17755366_A_G / 8_17721812_A_C | 1.3576985363683765e-05 / 1.972258766974004e-08 / 0.02629101974751153 | 0.001701316781434502 / 0.026616233857667596 / 0.002181030051469235 |
| 762 | CTSH_2 | 15_78922969_A_C / 15_78939184_A_AG | 1.4037598311677378e-05 / 0.0001924278188105154 | 0.010345021977573308 / 0.0344244477250216 |
| 763 | IL18_3 | 11_112150193_T_G / 11_112155193_G_C / 11_112155192_T_C | 1.461260124702572e-05 / 7.96641505141555e-07 / 0.03134154150698633 | 0.012472744364369587 / 0.011978242096605442 / 0.007248539214372238 |
| 764 | ZNF654_2 | 3_88139270_G_A / 3_88140191_T_C | 1.4751691487034687e-06 / 2.0819038805248358e-07 | 0.0018019171147236148 / 0.0019048877551503765 |
| 765 | ZNF589_6 | 3_48241161_TGCGC_T / 3_48241205_A_G / 3_48257949_T_C / 3_48268338_C_G / 3_48286239_T_C / 3_48286261_G_A | 1.6889590876869102e-06 / 1.1715920482680521e-06 / 7.920379942105592e-05 / 2.8491798121821795e-05 / 1.5027613326502343e-05 / 7.796162715352446e-06 | 0.0007986098597650371 / 0.0010457901523321454 / 4.006095509659407e-05 / 0.0020191705610664206 / 0.001627877596998014 / 0.0011919391649323414 |
| 766 | EPS15_6 | 1_51361249_T_C / 1_51405766_G_GACTC / 1_51440277_CTGTG_C / 1_51463832_TA_T / 1_51472751_T_G / 1_51461237_G_A | 1.6925862398730225e-06 / 4.1443509369940415e-05 / 0.031894015484001656 / 3.0950467922083264e-06 / 0.02951071302033457 / 0.01032478965873057 | 0.0002615744055786565 / 0.0005725418098281438 / 0.00017362501014406024 / 0.0002615744055786565 / 0.0045422702652321255 / 0.0029577065864897127 |
| 767 | ZNF266_2 | 19_9413509_A_G / 19_9420011_TG_T | 1.7177250175637761e-06 / 0.04040969628183889 | 2.6110373221371133e-14 / 0.004948136499581445 |
| 768 | BCAM_2 | 19_44820881_G_A / 19_44811510_C_T | 1.7938533698319987e-05 / 0.0006276370995178965 | 0.006588412083819078 / 0.021875016141096045 |
| 769 | C3orf38_3 | 3_88150029_T_C / 3_88150035_T_TC / 3_88150148_T_C | 1.7996666116084316e-06 / 0.00014178936922186315 / 2.595905755446793e-06 | 6.57647003118834e-05 / 4.649030455483649e-05 / 7.105213671060247e-05 |
| 770 | ERICH1_8 | 8_659132_C_G / 8_657766_C_G / 8_658018_C_T / 8_666590_T_A / 8_673593_G_A / 8_715858_C_T / 8_659879_A_C / 8_659039_G_A | 1.8121573621263876e-05 / 0.0010420319235614432 / 0.04660176454698252 / 0.004834244365989843 / 0.007260620745344446 / 0.04859602375702362 / 0.0025352106440479803 / 0.002455544576447661 | 0.0054140514901705895 / 0.043640948824396286 / 0.0013028832620993098 / 0.018154111038570942 / 0.01865482112843118 / 0.00034437810537597347 / 0.0461414202945825 / 0.014420687330437538 |
| 771 | LSR_2 | 19_35267372_G_GGGA / 19_35267177_A_C | 1.823380047726112e-06 / 0.03651632235421607 | 0.0021105674130373147 / 0.0028831204631532326 |
| 772 | PIK3C3_3 | 18_41955191_C_G / 18_41955194_A_G / 18_42043978_A_G | 1.9440372522869497e-06 / 0.0006320335833085862 / 0.023735103370508225 | 1.065744821934887e-06 / 0.0001342557450694381 / 0.00031280032152652704 |
| 773 | TAF3_4 | 10_7824594_T_C / 10_8013652_G_C / 10_8013913_G_A / 10_8014532_C_T | 2.0664435570944493e-05 / 0.004655883072306037 / 0.00943383216960874 / 0.0009463104379838767 | 0.03748233778862958 / 0.008249411816346357 / 0.004857051949006447 / 0.0014732747867095904 |
| 774 | FNBP1_2 | 9_129909080_T_TG / 9_129923982_A_G | 2.1184979283245958e-05 / 5.268485267589101e-05 | 0.013989753243576588 / 0.019443664939858312 |
| 775 | SACM1L_14 | 3_45719623_G_C / 3_45722143_A_G / 3_45722754_A_G / 3_45723052_T_C / 3_45731250_T_C / 3_45731280_G_A / 3_45732240_G_A / 3_45737644_A_T / 3_45705344_A_G / 3_45706937_G_A / 3_45713257_G_A / 3_45712995_C_A / 3_45689454_T_G / 3_45739488_A_G | 2.2026676208492585e-06 / 9.443816831049491e-07 / 0.0022018800476893614 / 3.5837125763699036e-08 / 4.4397997289151143e-07 / 1.2227532248856571e-06 / 1.3468374724431254e-06 / 7.150800554712763e-07 / 0.013551678428059705 / 0.0062092789567569535 / 0.0035804098855498063 / 0.005851841559996625 / 0.0028202119918153247 / 0.030877901512994674 | 2.7990310927885382e-05 / 2.6591646486392756e-05 / 0.006779520290921261 / 3.962907852818685e-05 / 1.1237814806460453e-05 / 4.359294069545172e-05 / 5.1558332133000766e-05 / 3.496973226569382e-05 / 0.0006684767742569695 / 7.302437009455565e-05 / 9.003284436221187e-05 / 0.005848457401461229 / 0.03994336344384322 / 5.7399601602553275e-06 |
| 776 | TXNL1_3 | 18_56602813_A_T / 18_56626612_C_T / 18_56651278_A_T | 2.210469276189849e-06 / 0.022001595468935316 / 0.02149358538709261 | 4.0417773765221675e-09 / 2.767068005468822e-10 / 1.7102012334179478e-05 |
| 777 | PTPN3_2 | 9_109436866_A_G / 9_109406452_T_G | 2.248398882883789e-05 / 0.008436388558613016 | 0.022560149794550868 / 0.025748841495573487 |
| 778 | LAMA3_9 | 18_23861753_C_T / 18_23915519_T_C / 18_23946123_C_T / 18_23949758_G_A / 18_23954737_C_A / 18_23954739_C_T / 18_23939340_A_C / 18_23713905_CT_C / 18_23846109_T_G | 2.2546401848550504e-07 / 0.0006963202810397933 / 1.582829210028338e-05 / 1.6534066895813288e-06 / 2.6769400746243374e-05 / 1.9933398900670928e-05 / 0.0008881294144847822 / 3.0126882423530804e-05 / 3.5426816292959363e-05 | 0.033914720695717084 / 0.013114315448110179 / 0.03066224880164858 / 0.025703076793439833 / 0.042551605063568684 / 0.030472466536971138 / 0.013225085724631118 / 0.01613050085470659 / 0.04009682047166014 |
| 779 | MTMR9_3 | 8_11284836_T_G / 8_11309724_G_A / 8_11322815_A_C | 2.349458678158868e-06 / 0.0004653758499732343 / 0.008022838484344897 | 2.4088220462781546e-11 / 0.0074905636429132404 / 0.008917788804222488 |
| 780 | ITGA6_4 | 2_172427981_A_G / 2_172427985_C_T / 2_172484735_A_G / 2_172490965_G_T | 2.55642040821661e-05 / 1.1751587238624405e-05 / 0.002854965230943433 / 0.025550057038402886 | 0.021886276374067117 / 0.023752544661456654 / 5.351259734935356e-06 / 0.007174810273459709 |
| 781 | KRI1_8 | 19_10557707_T_C / 19_10558277_G_A / 19_10560316_C_T / 19_10565667_A_T / 19_10565747_G_A / 19_10561817_C_T / 19_10562664_C_T / 19_10565811_G_GCC | 2.6474598014609052e-05 / 9.523794655306364e-05 / 0.00011786607794266038 / 0.0001616270444439651 / 3.4012624242046115e-05 / 1.477271100442178e-06 / 1.0798436673597302e-06 / 6.316959826240111e-06 | 0.00012897741560140272 / 3.792910022705542e-05 / 2.0569928046658807e-05 / 2.711645177509063e-07 / 3.211054485740389e-07 / 1.8153836897508705e-05 / 0.0002329401807770252 / 0.0008450486067550477 |
| 782 | GBP3_2 | 1_89007941_G_A / 1_89011034_A_T | 2.713567196210831e-05 / 0.047917709012617486 | 1.221534419837023e-06 / 2.259902209453749e-08 |
| 783 | FGFR2_2 | 10_121487530_T_C / 10_121520352_C_T | 2.796050535454376e-05 / 9.346629403777272e-05 | 0.015364585786772819 / 0.004955596968571121 |
| 784 | TNRC6C_2 | 17_78049826_A_C / 17_78067796_A_G | 2.865420177578161e-05 / 0.003859622145256892 | 0.03771979541922566 / 0.03295200627528048 |
| 785 | PDGFRB_2 | 5_150135511_G_A / 5_150129967_A_C | 2.9565587793102473e-05 / 0.0011142332419287124 | 0.007951396082365123 / 0.010884978116376998 |
| 786 | ASPH_2 | 8_61578734_T_G / 8_61638365_TA_T | 3.0349566769525607e-06 / 0.014784455717628972 | 0.00027481062695969863 / 0.0033421074285719613 |
| 787 | MRPS25_2 | 3_15065217_A_C / 3_15065038_A_C | 3.231333497421803e-05 / 0.03913000849637771 | 0.0017607662142123156 / 0.008302391831822605 |
| 788 | CNIH4_2 | 1_224356827_A_G / 1_224379302_G_A | 3.345540294148141e-05 / 1.3298114540105321e-05 | 8.270232693194595e-06 / 0.004957072960670954 |
| 789 | STAT5B_2 | 17_42212246_T_A / 17_42218217_T_TG | 3.457612678303974e-05 / 0.009108698459398929 | 0.049805612849012526 / 0.041598649064757576 |
| 790 | NRF1_5 | 7_129690176_C_G / 7_129709261_G_A / 7_129710330_A_C / 7_129711604_C_G / 7_129717099_T_G | 3.514964941916984e-05 / 0.0012574856804500286 / 0.0029569614211133396 / 0.0009106050710647207 / 0.0008333980926761285 | 0.0008588680251565 / 0.0020358531276104324 / 0.001863531871592876 / 0.00048643171799331433 / 0.006420212881434713 |
| 791 | C21orf58_2 | 21_46302477_A_G / 21_46322980_A_AG | 3.600317129022087e-06 / 0.000178616399448272 | 0.028316032350682373 / 0.0464048927112107 |
| 792 | EBF1_2 | 5_159099526_TA_T / 5_159099526_T_TA | 3.7020844162640586e-06 / 0.0061991425888554795 | 6.309766911659592e-06 / 0.009920112112628023 |
| 793 | PCNT_10 | 21_46438359_T_C / 21_46440304_C_T / 21_46442711_A_G / 21_46444647_CTTT_C / 21_46444900_C_T / 21_46444910_G_C / 21_46355631_G_C / 21_46425893_A_C / 21_46444675_T_G / 21_46444677_T_G | 3.8924131898677556e-05 / 0.00010294155569212726 / 0.00442543345514155 / 0.0007255960816556072 / 2.666879695038341e-05 / 2.666879695038341e-05 / 0.045239341586552524 / 0.0052653795831940926 / 0.011583428163992472 / 0.0012373038631552345 | 0.0007850146452497258 / 0.0011784720417395535 / 0.0010237263069919882 / 0.01824823490083048 / 0.00036147873774628185 / 0.00036147873774628185 / 0.0004512031541319047 / 0.01998375792506145 / 0.009046665740785187 / 0.01284951528238673 |
| 794 | RFT1_3 | 3_53104238_T_C / 3_53120116_ATTAACTGCAC_A / 3_53120127_T_G | 4.1039519054300644e-05 / 0.010916191776172972 / 0.0009241739865608092 | 0.019143884189355254 / 0.0012736601162827682 / 0.0003755806923286365 |
| 795 | NGLY1_4 | 3_25733865_A_C / 3_25736073_G_T / 3_25764388_T_C / 3_25732334_A_C | 4.193690016854428e-05 / 1.0629890346566115e-06 / 0.00018111373229034528 / 0.000337635257557846 | 0.004048589804059987 / 0.0001003348545752524 / 0.008193558074218642 / 0.0008517116761761035 |
| 796 | SHPRH_2 | 6_145955343_T_G / 6_145922945_GT_G | 4.197525341776357e-06 / 0.02497921302813516 | 0.0019437040989644704 / 0.0032085441168495693 |
| 797 | PSAP_4 | 10_71817510_G_A / 10_71820222_G_A / 10_71823763_G_C / 10_71825769_A_G | 4.253559292570684e-05 / 1.4584188008395623e-05 / 0.0007450217858733059 / 7.15024619363838e-07 | 0.005989723973244358 / 0.004815444492138627 / 0.005093191498317171 / 0.001137729147313085 |
| 798 | EPG5_4 | 18_45907942_A_G / 18_45860332_T_G / 18_45967161_TG_T / 18_45949582_G_A | 4.41056482155363e-05 / 0.0325761410753079 / 5.0265150457437094e-08 / 0.0009686733993730644 | 0.00018099150138285703 / 5.454441871402812e-06 / 0.0031405068156816515 / 0.04928013785599337 |
| 799 | GRB7_2 | 17_39746744_A_C / 17_39737973_T_C | 4.445333626793725e-06 / 3.7814817628535414e-05 | 0.015646545098240962 / 0.0275943135807812 |
| 800 | TBC1D5_5 | 3_17233681_G_C / 3_17238034_T_C / 3_17258641_A_C / 3_17428395_ATG_A / 3_17238102_T_G | 4.500069192335354e-07 / 5.287266410953234e-06 / 1.0934340959097885e-06 / 0.00038136339583758066 / 0.0015374412890621536 | 0.034850654424783314 / 0.048246561657752436 / 0.034850654424783314 / 9.180133184684152e-05 / 0.00428366923460265 |
| 801 | TTLL3_5 | 3_9825941_C_T / 3_9826893_A_G / 3_9829346_T_G / 3_9832986_G_A / 3_9835303_G_A | 4.506908857236149e-08 / 9.62440960091469e-07 / 6.721794266994746e-08 / 3.966565971028462e-07 / 0.047234941799100816 | 0.004512931116648239 / 0.009182452462015591 / 0.0016666988915567758 / 0.005845443747610279 / 0.00549007437147901 |
| 802 | HAUS1_4 | 18_46118343_C_T / 18_46123257_C_G / 18_46122767_C_T / 18_46118217_A_T | 4.791384820535998e-09 / 9.485176947904584e-06 / 0.0008672645013724843 / 0.00028116915718734436 | 0.0017369506644946814 / 0.009435638863427392 / 0.00147832294217736 / 0.0031860563996751264 |
| 803 | FGD4_3 | 12_32640343_A_C / 12_32640545_A_C / 12_32582270_A_C | 4.811506604588182e-07 / 0.027930843946287982 / 0.032681639982183666 | 0.0008756223675282764 / 0.0092856233481216 / 0.0015384650399147507 |
| 804 | PPDPF_2 | 20_63522320_T_G / 20_63521771_A_C | 5.287951236043515e-05 / 0.00689972604034751 | 0.043695255169413805 / 0.0005655672033991309 |
| 805 | ITGA2_2 | 5_53091493_C_T / 5_53042183_A_C | 5.4531358390517686e-05 / 0.03919199794742103 | 0.043791975990725485 / 0.0012604443318972665 |
| 806 | SLC44A3_5 | 1_94839884_A_G / 1_94865029_A_C / 1_94857210_T_G / 1_94857357_C_G / 1_94892383_G_T | 5.602338522082008e-05 / 0.046411065532556 / 0.007150508797521116 / 0.017457449518246654 / 0.009632517735858792 | 0.038972716080465035 / 0.008550555716824466 / 0.016460335501241437 / 0.008036938687219244 / 0.029740691948763408 |
| 807 | USP4_5 | 3_49284594_T_A / 3_49305742_G_A / 3_49324936_C_T / 3_49335612_A_G / 3_49302213_T_A | 5.782019897669962e-06 / 7.19205729889027e-06 / 1.709904241092868e-05 / 7.19205729889027e-06 / 5.51522445922424e-05 | 0.0014702427553570136 / 0.0018428609815186782 / 0.0024991863535684788 / 0.0018428609815186782 / 0.0003850173954240535 |
| 808 | CCDC12_4 | 3_46922012_T_C / 3_46923707_C_G / 3_46941247_T_C / 3_46923591_T_G | 5.914685515407129e-06 / 0.0018228664081414493 / 0.005309522612383735 / 0.004983454832882268 | 0.030142804350997518 / 0.03284103078371856 / 0.032410896819240385 / 0.04034475330385405 |
| 809 | TRIOBP_4 | 22_37723206_G_A / 22_37734378_A_C / 22_37765828_T_TG / 22_37750578_C_T | 5.971478816203375e-05 / 0.00027985715683595134 / 0.00029261375791339014 / 0.0030808446512811693 | 0.0051569691660451255 / 0.009407307485487609 / 0.022947122514129482 / 0.01009941891139795 |
| 810 | RAF1_2 | 3_12603508_C_T / 3_12606048_T_TG | 6.128646872671697e-07 / 0.0039523881023646075 | 0.0022616226810353037 / 8.653379217936721e-05 |
| 811 | FMNL1_5 | 17_45241411_G_C / 17_45241412_C_G / 17_45243751_T_G / 17_45232440_T_G / 17_45244864_G_C | 6.171874985510183e-05 / 0.00015929956646855425 / 0.003538404752618725 / 0.004784366369409091 / 3.9901595948387376e-05 | 0.0020906187745857413 / 0.0076474907511281205 / 0.013884774496511404 / 0.006430399709476225 / 0.0024365462048673877 |
| 812 | RIPK4_2 | 21_41746606_T_G / 21_41746170_T_C | 6.423837221659731e-05 / 0.00010177497615683857 | 0.014247426375762309 / 0.03297049438127817 |
| 813 | AGPAT5_2 | 8_6724964_A_C / 8_6757085_A_G | 6.429038885162565e-07 / 0.00364477408851887 | 1.266950151869815e-06 / 0.001321765776974001 |
| 814 | USP48_3 | 1_21703696_T_C / 1_21706077_T_G / 1_21706735_G_A | 6.450311033122228e-05 / 0.00028299304853152363 / 0.00012669514216415802 | 0.007845997236531468 / 0.01309954874203597 / 0.004449445235290158 |
| 815 | AP1M1_8 | 19_16206608_T_TG / 19_16226612_T_C / 19_16227721_G_A / 19_16228258_G_A / 19_16228904_C_T / 19_16233717_C_G / 19_16234288_T_C / 19_16228794_T_G | 6.528413032668653e-05 / 0.0064557081074910596 / 0.0024361725049911105 / 0.01837918810861549 / 0.025114292331133558 / 6.165054004198194e-05 / 0.002051667150159714 / 0.0008804072022582094 | 0.0008868669473225051 / 0.01491435109247843 / 0.00492438514382162 / 0.0030213758122107693 / 0.00454785100704076 / 6.396974124132157e-05 / 0.007302514064743812 / 0.008904488847639608 |
| 816 | DAZAP1_2 | 19_1432575_T_C / 19_1432578_A_C | 6.972933286419396e-09 / 0.00010616832462214354 | 0.008783799588482919 / 0.004625103934387489 |
| 817 | PACSIN3_2 | 11_47180569_G_A / 11_47182508_A_C | 7.134768403726839e-05 / 0.04020981298829434 | 0.021285924311691296 / 0.004000006496631303 |
| 818 | R3HCC1_4 | 8_23288582_A_G / 8_23291465_G_T / 8_23293365_T_G / 8_23290051_G_A | 7.2991599811489e-05 / 5.994421359171259e-05 / 0.012526023152146196 / 0.010041573920909331 | 0.02377854438814787 / 0.02377854438814787 / 9.39093538138813e-05 / 0.0033896878620269183 |
| 819 | SERPINB5_10 | 18_63486810_T_C / 18_63487155_C_T / 18_63489373_G_C / 18_63493054_T_C / 18_63493152_T_C / 18_63503267_T_C / 18_63503488_T_C / 18_63503549_A_G / 18_63503234_G_A / 18_63504446_A_T | 7.512909343200293e-07 / 1.61367941078967e-12 / 0.0017661748524282887 / 0.00358191163139034 / 1.15283914089761e-08 / 3.707481964958598e-05 / 3.699707858963291e-05 / 1.4974781606492456e-10 / 8.547425345240158e-05 / 0.001617719369677095 | 0.002310192116365421 / 0.0001900079796436893 / 0.0024982561142762962 / 0.004570527834506507 / 2.6119929305428517e-05 / 0.004811319593060203 / 0.00038813827261946135 / 0.0001894559075360232 / 0.008723212833525323 / 0.023248521588281557 |
| 820 | U2AF1_2 | 21_43107500_A_C / 21_43107485_A_C | 7.700487442691808e-05 / 0.0006563940756543221 | 3.5456060624197415e-05 / 0.0031649133811599275 |
| 821 | LLGL2_4 | 17_75569181_T_A / 17_75558442_C_G / 17_75573695_C_CCT / 17_75575074_T_C | 7.971949158890872e-06 / 3.785506483286314e-07 / 0.0064833437780985005 / 0.00395910816955325 | 0.018355040177942674 / 0.0004418073280201704 / 0.047670437975331784 / 0.004283559000108913 |
| 822 | PPFIA1_4 | 11_70365468_A_G / 11_70375250_G_T / 11_70337631_C_G / 11_70331778_TCAAAAA_T | 8.1777600824213e-05 / 2.2154751602898654e-10 / 0.007683460638024795 / 2.733195536548977e-07 | 0.01601938240153477 / 1.0104020665663723e-05 / 0.008528354106314544 / 0.002219921170959074 |
| 823 | STAG3_2 | 7_100197862_A_C / 7_100182660_G_A | 8.238419261021031e-05 / 0.008737491145039442 | 0.0017528283507844654 / 0.035261037489752685 |
| 824 | MYO5B_13 | 18_49837561_G_C / 18_49875910_A_C / 18_49937217_A_G / 18_49954290_G_A / 18_49847096_G_A / 18_49849562_C_G / 18_49849733_C_G / 18_49880543_A_G / 18_49880568_T_C / 18_49929553_C_T / 18_49929610_GA_G / 18_49954528_T_C / 18_49962255_A_G | 8.380774951798238e-06 / 0.006905476699523033 / 2.4263131433880795e-10 / 1.7494996128043332e-06 / 5.5387782704635815e-05 / 3.8985071268389133e-07 / 7.81858565470932e-07 / 1.54439656564615e-07 / 2.371423829111085e-08 / 8.182928222668989e-13 / 1.4176493799349745e-07 / 2.0981325041460703e-11 / 3.691444258026264e-11 | 0.03791686668587351 / 0.011592306302894794 / 0.0007689742137758647 / 0.011825548378506088 / 0.024802045476053625 / 0.0005688441791387698 / 0.0007265409595720793 / 0.010189243521059816 / 0.00680321425888459 / 7.83580041933832e-07 / 0.004868666362089778 / 9.442141848800156e-05 / 0.00020102188598339758 |
| 825 | ZNF441_2 | 19_11767280_T_G / 19_11778532_C_T | 8.6437303626739e-08 / 3.655373741478951e-07 | 0.00119501780413069 / 0.007941778018462287 |
| 826 | FAM83H_3 | 8_143728128_T_G / 8_143725596_G_C / 8_143730455_T_G | 9.215742981089235e-05 / 0.005987749784597274 / 0.0009621524329080232 | 0.005904909381665708 / 0.003207570177222234 / 0.011128551580065676 |
| 827 | KCNAB2_4 | 1_6085319_C_T / 1_6095272_T_C / 1_6085347_G_A / 1_6094357_C_T | 9.311243022811629e-05 / 0.0002214464879819671 / 0.007488052354416149 / 0.0004024482530986694 | 0.04271710391545418 / 0.04289813943359165 / 0.010697792728178102 / 0.030197643178852058 |
| 828 | MMP15_4 | 16_58038249_C_T / 16_58042518_A_G / 16_58045261_G_A / 16_58037634_A_C | 9.375120301838935e-05 / 1.005487978512005e-05 / 0.00013842386491697844 / 0.035127559966572304 | 0.006545735139458929 / 0.008269298799745639 / 0.016496855574598585 / 3.732680793190984e-05 |
| 829 | PKNOX1_3 | 21_43028653_G_C / 21_43028665_G_A / 21_43029807_G_A | 9.45086875135022e-05 / 9.45086875135022e-05 / 0.0028391505331848486 | 0.02993846952653303 / 0.02993846952653303 / 0.04630035756513505 |
| 830 | CNOT6L_3 | 4_77720488_T_G / 4_77720486_A_G / 4_77726534_A_C | 9.499774295611595e-07 / 0.0011515987198065605 / 1.5337206523072135e-05 | 0.00045440611666765506 / 0.003812687853894012 / 0.002323583718729919 |
| 831 | C1orf109_4 | 1_37683521_C_T / 1_37689469_G_GGT / 1_37689593_G_C / 1_37684175_A_G | 9.499906971175951e-07 / 3.357943291134777e-07 / 2.4786643546299445e-07 / 0.03129818295251388 | 0.0019238150218027989 / 0.005985910424044681 / 0.004025869106193675 / 0.0047335795687796075 |
| 832 | MAP7_2 | 6_136361034_G_A / 6_136411526_G_A | 9.631600220201912e-05 / 0.00020915694169969668 | 0.004233710215813943 / 0.03701019146859175 |
[표 18]에는 ERK_MAPK 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 18]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 40에는 [표 18]에 기재된 바이오마커들 중 주요 바이오마커들의 ERK_MAPK 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Variants(마커) | Var_Drug(pval) | Var_Exp(Pval) |
| 1 | INHBE_1 | 12_57456335_T_G | 5.77E-14 | 0.023018015 |
| 2 | SMAP1_1 | 6_70773272_G_A | 1.18E-08 | 0.029985176 |
| 3 | SPRY4_1 | 5_142319698_T_G | 6.07E-08 | 0.000420223 |
| 4 | THEM4_1 | 1_151909409_A_C | 8.56E-08 | 0.035981352 |
| 5 | SERPINB1_1 | 6_2837820_C_G | 1.44E-07 | 0.008676416 |
| 6 | EIF2B3_1 | 1_44926782_G_C | 7.36E-06 | 0.00572911 |
| 7 | DUSP6_1 | 12_89350540_G_A | 8.18E-06 | 0.001102792 |
| 8 | TOLLIP_1 | 11_1295591_A_C | 1.13E-05 | 0.041990571 |
| 9 | CDC5L_1 | 6_44387945_G_A | 0.000100417 | 0.000850114 |
| 10 | PAPD7_1 | 5_6746131_C_G | 0.000186035 | 0.046879537 |
| 11 | ABHD2_1 | 15_89199849_C_A | 0.000373834 | 0.002565266 |
| 12 | PLEKHM1_1 | 17_45436185_C_G | 0.002692591 | 0.035787973 |
| 13 | SMC6_1 | 2_17731999_A_C | 0.003115924 | 0.045907596 |
| 14 | RNF38_1 | 9_36400965_C_G | 0.004214532 | 0.007012003 |
| 15 | METTL16_1 | 17_2415256_G_C | 0.007239539 | 0.043637945 |
| 16 | PARP2_5 | 14_20351190_T_A / 14_20354336_G_T / 14_20344985_T_C / 14_20354983_A_C / 14_20354994_T_C | 0.0003461397642250317 / 0.008144629651779057 / 1.6511185678613746e-06 / 9.423861936900617e-06 / 4.248961897732616e-05 | 0.0026213592391782425 / 0.0343587058197046 / 0.0388723494826529 / 0.009448771221863612 / 0.035110640891692815 |
| 17 | CRYL1_6 | 13_20439533_A_G / 13_20439514_CA_C / 13_20404113_C_G / 13_20404176_A_C / 13_20489466_A_C / 13_20512438_C_G | 0.0007457569282103447 / 0.04490288969730257 / 5.4112288097843236e-05 / 0.0004125161353078136 / 7.340308839823958e-10 / 0.0008144017559447111 | 0.02254568941445808 / 0.006925654927699 / 0.014412490268573512 / 0.0358490969666835 / 0.0036810252474824734 / 0.0005690585314639865 |
| 18 | MBD2_2 | 18_54222304_G_C / 18_54224621_A_C | 0.0009174927734817775 / 0.003370522943374522 | 0.041746449937120685 / 0.0024467066581282037 |
| 19 | NUCKS1_3 | 1_205727543_G_A / 1_205720599_G_C / 1_205719615_A_C | 0.0019226380117114328 / 5.15182042228384e-07 / 5.169743185885884e-06 | 0.007966391204853542 / 0.0020116543690140926 / 1.829062095579077e-05 |
| 20 | TMEM8A_4 | 16_377516_T_C / 16_374277_G_A / 16_377010_C_T / 16_375326_T_G | 0.0022458300017618115 / 0.0004991219763661549 / 0.008152821570691773 / 0.00033905970470333573 | 0.02280191742379471 / 0.008448241096869875 / 0.02464199505583077 / 0.03164430214292932 |
| 21 | MCM8_5 | 20_5950428_T_C / 20_5954739_T_C / 20_5967525_G_A / 20_5963301_T_G / 20_5983067_T_G | 0.002650766144390827 / 0.0020883309843753076 / 7.538671246466503e-12 / 0.0005138671174250025 / 0.00032159758644408336 | 0.02450503355623649 / 0.0030061115573713558 / 0.02006455848870967 / 0.0209284066776318 / 0.012878505995892143 |
| 22 | COPS3_3 | 17_17280719_G_T / 17_17249049_GAA_G / 17_17280660_A_C | 0.0027601645216709264 / 0.0055818454987667495 / 0.009754104106729505 | 0.019538058668087298 / 0.04875712280071096 / 0.02319033941785423 |
| 23 | NEDD1_2 | 12_96937308_A_C / 12_96936634_A_G | 0.004287874507177774 / 0.0016187072229015974 | 0.019399114812349873 / 0.02229964139566365 |
| 24 | HDAC6_3 | X_48803171_T_G / X_48817284_T_G / X_48817251_CAA_C | 0.007173863496387051 / 0.0004972749557463768 / 0.0027277691674834114 | 0.008701773238861378 / 3.6233113107314475e-06 / 0.00929153924222002 |
| 25 | MRPL39_6 | 21_25592759_G_A / 21_25601549_G_T / 21_25603910_C_T / 21_25603925_C_T / 21_25604009_G_A / 21_25599683_T_C | 0.007753577611892022 / 0.0015571108862256187 / 0.005054758659783033 / 0.00740873550689033 / 0.005591788896050463 / 0.03750113388472616 | 0.033844596383331746 / 0.005711821633941189 / 0.043198910460816656 / 0.020407458243495952 / 0.026357543170222462 / 0.002961561939886723 |
| 26 | ZBTB8OS_2 | 1_32621836_G_A / 1_32634036_A_G | 0.010623328091650126 / 0.005807902867508034 | 0.00035085154745507385 / 0.001609648081432905 |
| 27 | SNRPC_3 | 6_34767901_T_C / 6_34767875_CT_C / 6_34767875_C_CT | 0.016258858934554518 / 0.0255807459946655 / 0.008409734593854818 | 0.0021977163744789038 / 0.005833052025345314 / 0.047890724740450176 |
| 28 | SH3TC2_5 | 5_149010200_G_A / 5_149026823_T_C / 5_149040673_A_C / 5_149040676_A_C / 5_149004975_C_T | 0.036452606469764885 / 7.993368579087101e-05 / 1.313354358475822e-12 / 1.6742742304793365e-07 / 3.0188094863269486e-08 | 0.005163368200425915 / 0.02459748424962984 / 0.04603790254373362 / 0.03254802106345967 / 0.01898788013634638 |
| 29 | NUP188_7 | 9_128970680_G_T / 9_128981422_CT_C / 9_128999694_A_C / 9_128993243_C_G / 9_129003287_A_C / 9_128952722_CAAAA_C / 9_128981422_CTT_C | 0.03889727834709586 / 5.679744903985549e-07 / 0.00015792708806478532 / 0.00011477857081826123 / 0.006528287639189813 / 1.3483326927899365e-05 / 0.001011406252669107 | 0.006235319995753044 / 0.0026090470755132837 / 0.04562376131737803 / 0.034372383646284414 / 0.006351306341421021 / 0.030396670064505107 / 0.0486576378436576 |
| 30 | PDCD5_2 | 19_32581360_T_C / 19_32581212_C_G | 1.0613555124907784e-06 / 0.01707686442489131 | 1.930613826710712e-05 / 0.00963168433129465 |
| 31 | PCDH1_5 | 5_141865023_A_C / 5_141864261_A_C / 5_141864335_T_G / 5_141854096_T_G / 5_141864895_A_C | 1.146087693284126e-13 / 2.954523514000492e-06 / 1.2399540998886776e-05 / 6.010776449757326e-05 / 1.3125365237964413e-06 | 0.00022379266342278662 / 0.0017861354200376558 / 0.02539846277902666 / 0.023845011173266668 / 0.014684779508972238 |
| 32 | ARL6IP6_3 | 2_152718606_T_G / 2_152718941_T_G / 2_152718947_T_G | 2.1444201135699293e-06 / 3.4179740940841686e-10 / 5.150737082224498e-05 | 1.916382486428584e-05 / 0.0014347496711839814 / 0.0018772601891545288 |
| 33 | TPP1_3 | 11_6616021_T_G / 11_6619456_A_C / 11_6616207_T_G | 3.898164047661344e-05 / 6.206193500590457e-06 / 7.13357999675385e-06 | 0.03721832122361987 / 0.0021180587349231865 / 0.022734527785541702 |
| 34 | SLC35B2_2 | 6_44253096_A_C / 6_44255584_T_G | 4.1264755521968e-08 / 2.206940612751773e-06 | 0.045514675788588387 / 0.0354190738183241 |
| 35 | ETV5_6 | 3_186057145_T_G / 3_186057158_T_G / 3_186105591_G_A / 3_186064432_A_G / 3_186057367_T_G / 3_186057421_A_C | 4.28224233645744e-14 / 2.8538105380699127e-12 / 3.537860306738235e-07 / 3.53456731728789e-05 / 8.933112160257351e-07 / 2.0618345030808515e-05 | 0.000899440048018852 / 5.426858809490545e-05 / 0.008678217049363252 / 0.012387170842740151 / 0.01078700094209001 / 0.04370939373064901 |
| 36 | DUSP4_2 | 8_29340229_A_C / 8_29337473_A_C | 4.4035389796360024e-07 / 0.0013351841168008725 | 0.01853773742959819 / 0.013684370845169195 |
| 37 | ST3GAL4_3 | 11_126408340_T_G / 11_126406566_A_C / 11_126424657_A_G | 4.582342844339244e-12 / 1.1939071093750443e-06 / 6.212889562458534e-09 | 7.802484819683297e-05 / 0.006286854884921811 / 0.03738872157996522 |
| 38 | SKP2_3 | 5_36183922_T_C / 5_36168236_A_G / 5_36168246_T_G | 4.974059042110084e-09 / 2.3219549423702208e-12 / 1.6076332463417848e-08 | 0.008092624659189506 / 0.01597032245832584 / 0.022784487945753537 |
| 39 | GPBP1_3 | 5_57230956_G_A / 5_57231420_T_C / 5_57251232_G_A | 4.99115882517327e-06 / 1.8819931578981247e-06 / 2.491196233571318e-05 | 0.038048986044057084 / 0.04556667822911722 / 0.018325268985280727 |
| 40 | CMTM7_2 | 3_32441841_T_G / 3_32454197_C_G | 5.20316947282785e-11 / 1.865488768400554e-06 | 0.022587609002975642 / 0.027278626571090647 |
| 41 | LRP5_2 | 11_68429633_T_G / 11_68448944_A_C | 8.179359573414423e-10 / 2.733681134387847e-06 | 0.01579807768279053 / 0.024681714140317668 |
| 42 | ETV4_2 | 17_43544973_A_C / 17_43533230_T_G | 8.216801793356959e-07 / 9.218453009083366e-06 | 0.025227174262734704 / 0.0007956602344066278 |
[표 19]에는 IGFR 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 19]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 41에는 [표 19]에 기재된 바이오마커들 중 주요 바이오마커들의 IGFR 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Variants(마커) | Var_Drug(pval) | Var_Exp(Pval) |
| 1 | SEPT6_1 | X_119618658_T_G | 1.08E-09 | 0.00240717 |
| 2 | EPHA2_1 | 1_16148437_A_C | 2.39E-08 | 0.003022958 |
| 3 | VRK1_1 | 14_96853031_T_G | 3.01E-06 | 0.034233405 |
| 4 | ACTR3_1 | 2_113934245_G_T | 4.92E-06 | 0.01245207 |
| 5 | FOS_1 | 14_75280999_A_C | 6.24E-06 | 0.001488063 |
| 6 | FCHO2_1 | 5_73082876_ATT_A | 1.08E-05 | 0.029256929 |
| 7 | RAC1_1 | 7_6401802_T_G | 2.22E-05 | 0.003141263 |
| 8 | CXCR5_1 | 11_118886492_C_G | 6.30E-05 | 0.044645013 |
| 9 | KCNQ5_1 | 6_72622312_C_G | 8.39E-05 | 0.005821769 |
| 10 | ACSS2_1 | 20_34920910_T_G | 8.92E-05 | 0.038456731 |
| 11 | CRLF3_1 | 17_30792416_T_G | 0.000107788 | 0.014789711 |
| 12 | TSEN34_1 | 19_54192354_T_G | 0.000113175 | 0.001848481 |
| 13 | GTF2IRD1_1 | 7_74512993_A_G | 0.000122837 | 0.006481631 |
| 14 | CECR1_1 | 22_17188516_G_C | 0.000127223 | 0.003052868 |
| 15 | MAP4K1_1 | 19_38617327_T_G | 0.000134054 | 0.013203631 |
| 16 | PAPSS2_1 | 10_87727355_T_G | 0.000165034 | 0.012652487 |
| 17 | LAMC1_1 | 1_183131172_CAA_C | 0.000221332 | 0.002417084 |
| 18 | TBX21_1 | 17_47742656_A_C | 0.000232988 | 0.004538883 |
| 19 | PNRC2_1 | 1_23961703_G_C | 0.000287734 | 0.015853081 |
| 20 | HSPG2_1 | 1_21885485_A_C | 0.00029294 | 0.028105373 |
| 21 | CD72_1 | 9_35610848_A_C | 0.000296281 | 0.049937736 |
| 22 | KLF3_1 | 4_38689006_A_C | 0.000348148 | 0.015121455 |
| 23 | ZNRF3_1 | 22_29048501_A_C | 0.000348188 | 0.024970519 |
| 24 | ASAP2_1 | 2_9399979_T_G | 0.000416146 | 0.021780475 |
| 25 | CCDC69_1 | 5_151185396_T_C | 0.000422551 | 0.005439839 |
| 26 | EPS15_1 | 1_51472751_T_G | 0.000562256 | 0.00454227 |
| 27 | CBR1_1 | 21_36071267_G_C | 0.000703843 | 0.005777456 |
| 28 | CST3_1 | 20_23634133_A_C | 0.000813367 | 0.047435887 |
| 29 | IGF1R_1 | 15_98934682_T_G | 0.00081535 | 0.004668174 |
| 30 | MEI1_1 | 22_41699656_A_C | 0.000847426 | 0.019192604 |
| 31 | PTPN6_1 | 12_6946697_T_C | 0.000924277 | 0.002400753 |
| 32 | PMEPA1_1 | 20_57700062_A_G | 0.000939285 | 0.036764657 |
| 33 | WASL_1 | 7_123692324_GA_G | 0.001014849 | 0.000396379 |
| 34 | ARHGAP15_1 | 2_143228433_T_C | 0.001096444 | 0.039221572 |
| 35 | CLDN12_1 | 7_90413108_T_G | 0.00113931 | 0.004520847 |
| 36 | UACA_1 | 15_70669470_GA_G | 0.001211403 | 0.03571568 |
| 37 | TRIM2_1 | 4_153276097_A_G | 0.001260338 | 0.011894098 |
| 38 | RCC2_1 | 1_17413487_C_A | 0.001306044 | 0.02349276 |
| 39 | CD48_1 | 1_160711863_GA_G | 0.001708644 | 0.04718285 |
| 40 | GLCE_1 | 15_69261053_A_G | 0.001722968 | 0.004293961 |
| 41 | C21orf91_1 | 21_17793434_T_G | 0.001758128 | 0.044828498 |
| 42 | SIGLEC10_1 | 19_51417063_T_G | 0.00177184 | 0.045299996 |
| 43 | NCKAP1_1 | 2_182967372_CA_C | 0.001831659 | 0.004822611 |
| 44 | CD86_1 | 3_122103557_A_C | 0.001895858 | 0.046671667 |
| 45 | ERRFI1_1 | 1_8013331_A_G | 0.001920351 | 0.000188249 |
| 46 | PTPRC_1 | 1_198703381_A_C | 0.001955402 | 0.027037687 |
| 47 | CTDSPL_1 | 3_37957127_T_G | 0.002306486 | 0.04933152 |
| 48 | TAF4B_1 | 18_26286027_C_A | 0.00252716 | 0.005234164 |
| 49 | CDC42BPB_1 | 14_102939620_T_G | 0.002756257 | 4.78E-05 |
| 50 | CTBP2_1 | 10_125026073_A_G | 0.002878802 | 0.03391949 |
| 51 | RASAL3_1 | 19_15458567_G_C | 0.003342618 | 0.038134018 |
| 52 | HLA-DOB_1 | 6_32813293_A_C | 0.003408106 | 0.048853006 |
| 53 | WAS_1 | X_48691219_A_C | 0.00381355 | 0.02612273 |
| 54 | HBS1L_1 | 6_134965300_CA_C | 0.004012929 | 0.010966837 |
| 55 | FCRL5_1 | 1_157518564_T_C | 0.004367637 | 0.023539142 |
| 56 | UHRF2_1 | 9_6482002_G_T | 0.004387102 | 0.007025127 |
| 57 | SPR_1 | 2_72891611_A_C | 0.005381455 | 0.000101783 |
| 58 | DHX32_1 | 10_125867071_T_C | 0.006025442 | 0.015306739 |
| 59 | DAG1_1 | 3_49531399_T_G | 0.006122816 | 0.000829773 |
| 60 | RAVER2_1 | 1_64768580_T_G | 0.007604338 | 0.049067483 |
| 61 | KIAA0922_1 | 4_153635457_C_T | 0.007681106 | 0.042172485 |
| 62 | ITGAV_1 | 2_186637080_T_G | 0.0079744 | 0.00113911 |
| 63 | MSL3_1 | X_11772199_A_C | 0.00797531 | 0.040182738 |
| 64 | LAPTM5_1 | 1_30733959_T_C | 0.008095451 | 0.005337526 |
| 65 | TPBG_1 | 6_82364929_T_C | 0.009219323 | 0.003828919 |
| 66 | CD52_1 | 1_26320120_TAA_T | 0.009857578 | 0.041028395 |
| 67 | APOBEC3G_1 | 22_39086265_G_T | 0.009915615 | 0.042244805 |
| 68 | ZNF107_1 | 7_64708051_G_A | 0.010400777 | 0.013846694 |
| 69 | PALLD_1 | 4_168691310_GT_G | 0.011706523 | 0.009714355 |
| 70 | WTAP_1 | 6_159753424_T_G | 0.01384856 | 0.00215073 |
| 71 | HCLS1_1 | 3_121634273_T_G | 0.019280657 | 2.45E-06 |
| 72 | AVPI1_1 | 10_97677649_A_G | 0.021081758 | 0.001581419 |
| 73 | FAM129B_1 | 9_127578987_C_T | 0.021421759 | 0.016089528 |
| 74 | SH3RF1_1 | 4_169096709_G_A | 0.024084182 | 0.008799276 |
| 75 | DR1_1 | 1_93361899_T_A | 0.025156433 | 4.48E-05 |
| 76 | CTTNBP2NL_1 | 1_112457049_C_A | 0.028077079 | 0.00620874 |
| 77 | PPP3CC_1 | 8_22539268_TC_T | 0.032546359 | 0.004572653 |
| 78 | WIPF1_1 | 2_174585550_T_G | 0.037854213 | 0.000483959 |
| 79 | RNGTT_1 | 6_88769645_C_T | 0.04013553 | 0.002545266 |
| 80 | CUEDC1_1 | 17_57873465_G_A | 0.046175827 | 0.009658282 |
| 81 | TMEM106A_2 | 17_43216747_A_C / 17_43216763_T_C | 0.00010599595448116978 / 0.0011257303404920308 | 0.0005249300563644175 / 0.0005036765332449491 |
| 82 | ARHGAP9_2 | 12_57474996_G_A / 12_57474460_G_A | 0.00010627135291362362 / 0.0006872861852919692 | 0.036897912823510064 / 0.04135748735535435 |
| 83 | ARHGAP25_3 | 2_68775067_A_G / 2_68818005_T_G / 2_68818023_T_G | 0.00011953760418312583 / 1.4150706205617486e-06 / 0.0059084060389890105 | 0.04538887525617117 / 0.0040433016624282225 / 0.00032630206809361283 |
| 84 | LMNA_2 | 1_156134461_T_G / 1_156139242_AT_A | 0.00013744315797654898 / 0.021258069595818274 | 0.029742625031540286 / 0.04237931129547261 |
| 85 | DAGLA_2 | 11_61734985_A_C / 11_61728297_A_C | 0.00016688573126791192 / 8.09952511657234e-05 | 0.004132304336839055 / 0.025660366426589504 |
| 86 | NR2F6_2 | 19_17240636_T_G / 19_17232479_A_C | 0.0002005112664246795 / 0.004658617789678825 | 0.0007905076911971658 / 0.04560309985715085 |
| 87 | PLEKHA1_2 | 10_122406608_C_A / 10_122426897_T_G | 0.0002168843436880945 / 0.005333013480801039 | 0.013835632948640248 / 0.02718721223708819 |
| 88 | APP_2 | 21_25881669_T_G / 21_25881706_A_T | 0.00025836883792981226 / 0.012490170798802495 | 0.0009005203285702301 / 0.007363278374314075 |
| 89 | ATP1B1_2 | 1_169127312_A_G / 1_169131404_A_C | 0.0002769045008439269 / 0.0004647954716516378 | 0.009381431280957959 / 0.04764456683437238 |
| 90 | IL10RA_2 | 11_117999603_A_C / 11_117999569_T_G | 0.0003635149788055047 / 0.002791509228208489 | 0.033136103226175016 / 0.042909053419655285 |
| 91 | ERICH1_7 | 8_658279_A_G / 8_659132_C_G / 8_659777_T_G / 8_666991_A_G / 8_673593_G_A / 8_659879_A_C / 8_664843_G_C | 0.00036987702944603015 / 5.389836081615414e-05 / 0.042347501906470714 / 0.03423827293146818 / 0.002457155038695027 / 0.005217531740497581 / 0.03193881349739397 | 0.004174871941240723 / 0.0054140514901705895 / 0.007294372779032101 / 0.0012649483439199085 / 0.01865482112843118 / 0.0461414202945825 / 0.005281332497371782 |
| 92 | ITGB5_4 | 3_124769064_T_G / 3_124809087_T_G / 3_124817591_T_G / 3_124859372_A_C | 0.0004279586059829587 / 0.0005503781084358106 / 2.8998064871450438e-05 / 0.007293322508081707 | 0.0006588536356118503 / 5.4585187494895796e-05 / 0.004666117329251896 / 6.144253538463827e-06 |
| 93 | RFTN1_4 | 3_16357670_G_A / 3_16369972_C_G / 3_16433938_A_G / 3_16316966_A_C | 0.0005124144917873522 / 0.0007740692582134723 / 0.02739900235302105 / 1.3310696006188425e-05 | 0.014764917085914387 / 4.009218111239421e-08 / 9.30606513108498e-07 / 0.008243705342181723 |
| 94 | RBFOX2_4 | 22_35759903_A_G / 22_35746471_A_C / 22_35761128_GA_G / 22_35745982_A_C | 0.0005772251529531363 / 0.0026032665751075587 / 0.0005990432899641425 / 0.00370365047461572 | 0.0021501446732444386 / 0.003606660377686972 / 0.04845122900481105 / 0.009865449869643949 |
| 95 | VSIG10_3 | 12_118095590_T_G / 12_118073908_T_G / 12_118095640_G_C | 0.0006180518934147943 / 0.000288504312752602 / 0.003668316042902092 | 0.013058144491121623 / 0.0019761216603789984 / 0.03443934455659579 |
| 96 | PLEKHG3_2 | 14_64741663_T_G / 14_64743474_T_G | 0.0007814263254356411 / 0.001157048611523175 | 5.022222887595109e-05 / 0.0004341351157000161 |
| 97 | ATP11A_7 | 13_112832759_A_G / 13_112871823_T_C / 13_112860417_A_C / 13_112810736_A_C / 13_112856140_A_C / 13_112832768_A_C / 13_112860332_A_C | 0.0007951918344761818 / 0.0005482830943215422 / 0.0008173410245384687 / 0.00028609539850556404 / 0.0005652380914145368 / 0.01755140978606275 / 0.0026211055327575693 | 0.03593739412008719 / 0.030074291108272512 / 0.013638179892540932 / 0.02325523862538697 / 0.008605914805152383 / 0.0022773790348338983 / 0.006067631423556552 |
| 98 | RUNX3_2 | 1_24907301_T_G / 1_24907326_T_G | 0.0008468237773895464 / 0.006925491973632575 | 0.0479402881785652 / 0.03367486268556343 |
| 99 | CTTN_3 | 11_70419876_A_C / 11_70419880_T_C / 11_70407283_C_T | 0.000966697322875658 / 3.5345921815367516e-05 / 0.005641133258474765 | 0.00030309409522359497 / 0.003131141961303907 / 0.005941149857145408 |
| 100 | CCDC28A_2 | 6_138785343_A_C / 6_138792859_T_C | 0.0013622718680866052 / 0.005185054082793079 | 0.011499421256994664 / 0.046299906365056015 |
| 101 | CD63_3 | 12_55725557_A_C / 12_55725568_A_C / 12_55727027_A_C | 0.0015370519252913715 / 4.143328592583745e-05 / 0.0004442658715243917 | 0.006833645667760305 / 0.006277176385590093 / 0.0005016030317793939 |
| 102 | SCARB2_2 | 4_76179751_A_C / 4_76179754_T_C | 0.0016868597515864868 / 0.0015619118205883007 | 0.009508010711643462 / 0.003674712454161551 |
| 103 | TJP1_4 | 15_29737354_A_C / 15_29761137_A_C / 15_29761418_A_C / 15_29718609_T_G | 0.001722668303128766 / 0.001802650233952311 / 0.0039948883415691075 / 0.0004981143114140755 | 0.03635480241931981 / 0.005695684405240236 / 0.0032087876676378537 / 0.035918560945748516 |
| 104 | CD84_2 | 1_160549875_A_G / 1_160550877_C_G | 0.0018095916002787247 / 0.0007689474612337844 | 0.011914227680681896 / 0.04088607952168802 |
| 105 | IKZF1_3 | 7_50368194_A_C / 7_50382645_A_C / 7_50387420_G_C | 0.0018105241430139086 / 0.014707321465940356 / 0.001698752501804824 | 0.008403541889994377 / 0.009343110426337882 / 0.005840601801883746 |
| 106 | LCP1_3 | 13_46143111_T_C / 13_46143326_T_G / 13_46143333_A_T | 0.0018838737568387656 / 0.0030138622548272647 / 0.002533014213361492 | 0.004087453394348643 / 0.0014213406956657436 / 0.005160539969200112 |
| 107 | FAM177A1_2 | 14_35081207_T_C / 14_35081218_T_C | 0.0021562993680550448 / 0.0011900365723686852 | 0.020934419309292008 / 0.02682119468565008 |
| 108 | WDR91_2 | 7_135211631_T_C / 7_135187272_A_C | 0.0024692334154964657 / 0.032950442555311085 | 5.806021129546451e-05 / 0.006217596359933296 |
| 109 | KLHL6_3 | 3_183492078_A_C / 3_183508233_G_T / 3_183508495_A_C | 0.0026331756981726236 / 0.022647868110278375 / 7.774725762863598e-05 | 0.03828309904439229 / 0.005722620392157443 / 0.025101287121564474 |
| 110 | ZNF543_2 | 19_57329179_A_G / 19_57328339_A_C | 0.002905904571144909 / 0.0017155256244295665 | 0.0030296713890405878 / 0.0008395371531401164 |
| 111 | PLEK_6 | 2_68380987_A_C / 2_68380990_A_C / 2_68386526_T_G / 2_68388306_A_G / 2_68388311_A_G / 2_68395610_G_T | 0.0029347945425916644 / 0.002463266314490245 / 0.0008850637706738338 / 9.333617954680645e-06 / 0.0006950651263355477 / 0.0073361864658662125 | 0.0018651167043750433 / 0.004434568689990568 / 0.0232360676072928 / 0.012112306050675708 / 0.028732570109628937 / 0.04207168924285536 |
| 112 | KDM4C_2 | 9_6990364_G_T / 9_7103596_C_T | 0.0029959320396048127 / 0.031190087077651845 | 0.01165227785409256 / 0.0003043755324224803 |
| 113 | STAG3_6 | 7_100197862_A_C / 7_100197337_A_T / 7_100197348_T_C / 7_100201126_G_C / 7_100180467_A_G / 7_100202616_A_T | 0.003032352954227882 / 0.0003006428065929603 / 0.0015227072304436168 / 7.395320763427399e-05 / 2.7805601294277643e-05 / 0.0008727651283899594 | 0.0017528283507844654 / 0.0366941229125814 / 0.023320205307304158 / 0.027602097077102532 / 0.04660308396540184 / 0.020109594472644786 |
| 114 | WDFY4_2 | 10_48733932_A_G / 10_48709976_C_T | 0.00343399726598083 / 0.014958425459696244 | 0.04160917875360734 / 0.036092320181802036 |
| 115 | PEX3_2 | 6_143462894_AT_A / 6_143468044_A_T | 0.0038068988591272368 / 0.004816984657632503 | 0.01772831437707046 / 0.001265609891969809 |
| 116 | FERMT3_2 | 11_64207498_T_G / 11_64220073_T_G | 0.004734854868796705 / 0.0003860702269228193 | 6.601869405274685e-06 / 0.034308160983635066 |
| 117 | ARHGAP5_3 | 14_32092970_T_C / 14_32154828_T_C / 14_32092963_G_C | 0.00497062236861118 / 0.0024371349542205195 / 0.03352695059876293 | 0.000109609141495362 / 0.0028505632724505807 / 0.007275592799482284 |
| 118 | NGLY1_3 | 3_25733762_T_C / 3_25736073_G_T / 3_25732334_A_C | 0.0050051985544428655 / 0.00013354579539043645 / 0.00040433124284776166 | 0.0004571643127465467 / 0.0001003348545752524 / 0.0008517116761761035 |
| 119 | NCKAP1L_3 | 12_54532103_A_T / 12_54509948_A_C / 12_54542688_G_C | 0.005115130095563281 / 0.006142923665719964 / 0.003395761947631717 | 0.006178462220094093 / 0.01506335399115959 / 0.04657402586559346 |
| 120 | DCK_2 | 4_71023692_C_A / 4_71022615_CTT_C | 0.00551147320732032 / 0.003204858946259472 | 0.03456399228988244 / 0.04731976901534782 |
| 121 | CNOT10_2 | 3_32705030_A_G / 3_32717271_G_A | 0.005986207049477181 / 0.010027593265925021 | 0.0007110070373588129 / 0.0032142136890770555 |
| 122 | ZNF430_2 | 19_21033730_G_A / 19_21022773_T_G | 0.0060011071152059935 / 0.001269711279469131 | 3.875366882434858e-05 / 0.024171318376603662 |
| 123 | DIRC2_2 | 3_122795117_A_C / 3_122856322_A_G | 0.006254194164645703 / 0.003207873756680403 | 0.006533610459085206 / 0.013416690563532 |
| 124 | DENND1C_2 | 19_6469618_A_C / 19_6466439_T_G | 0.0067186287718049645 / 0.0016600261620732227 | 0.03949757317188018 / 0.022653353998851232 |
| 125 | MRPL39_3 | 21_25592788_C_A / 21_25601549_G_T / 21_25599683_T_C | 0.007244177399862964 / 0.02581153853071456 / 0.006446955687932745 | 0.0040263096113157286 / 0.005711821633941189 / 0.002961561939886723 |
| 126 | POLH_2 | 6_43587207_T_G / 6_43587205_A_G | 0.007282790737761695 / 0.004119102235979657 | 0.002197498680435875 / 0.0001905626583652103 |
| 127 | LTBP3_4 | 11_65547976_T_G / 11_65547974_A_G / 11_65541348_A_C / 11_65543270_A_C | 0.008230993013661442 / 0.002905381602762654 / 3.41563836791927e-05 / 0.000404704876316852 | 0.0010020580443514707 / 0.013780067605462305 / 0.02423580877660449 / 0.030868539513201374 |
| 128 | CCND1_2 | 11_69650913_A_G / 11_69643258_A_C | 0.009099246706999426 / 0.0062885656582625715 | 0.024298615321604846 / 0.0008578909246964013 |
| 129 | CTNNA1_4 | 5_138812304_T_G / 5_138933920_C_T / 5_138932696_A_G / 5_138812295_G_A | 0.009367597372283164 / 6.3503870330673816e-06 / 0.025253708380473885 / 0.0007665667912501635 | 0.013339032203366944 / 0.00010488952235634391 / 0.007557173168109447 / 0.014548265287747147 |
| 130 | WDR7_2 | 18_56679573_T_G / 18_56781547_G_A | 0.00936770621562205 / 0.0029337854053434692 | 1.7583606026050092e-08 / 0.0071713352600959014 |
| 131 | RCL1_5 | 9_4844704_T_C / 9_4844778_A_C / 9_4849647_T_C / 9_4860917_G_GT / 9_4860980_G_A | 0.01015934986765833 / 0.008166765063815772 / 0.013723578341305795 / 0.006228375621470136 / 0.0009546809601140933 | 0.001687161016128972 / 0.0053342789487147045 / 0.004306767506877943 / 1.3652309819438526e-05 / 0.014590769537426704 |
| 132 | ZCCHC14_5 | 16_87414470_A_C / 16_87411666_T_C / 16_87412604_T_G / 16_87412609_T_G / 16_87407905_T_G | 0.01093006007749231 / 0.004904074942282202 / 0.0043682847900583565 / 0.00032200703750807235 / 0.00016922609654741882 | 0.007871655864135534 / 0.012673355773035487 / 0.00292819630706063 / 0.0093411624607831 / 0.04674575207321762 |
| 133 | TOM1L1_3 | 17_54937096_G_T / 17_54937101_G_T / 17_54947274_A_C | 0.011389249245863157 / 0.02378503173158879 / 6.37493870407225e-05 | 0.0005351253630963304 / 4.7382046214109506e-05 / 0.0003719570020930906 |
| 134 | SVIL_2 | 10_29532000_A_C / 10_29486218_G_T | 0.014203541816552456 / 3.6685991514458535e-06 | 0.005199248570547408 / 0.02127330473082788 |
| 135 | TEAD4_2 | 12_3019250_C_T / 12_3022032_A_C | 0.02289390603064881 / 0.0001066489771189534 | 0.0016254072731388984 / 0.0001892435681560084 |
| 136 | ARHGAP30_2 | 1_161052161_T_G / 1_161069551_T_G | 0.026797750313656932 / 0.0002673414213531623 | 0.0011705834898046734 / 0.030642225735204174 |
| 137 | FMNL1_3 | 17_45232440_T_G / 17_45238511_T_G / 17_45238503_C_G | 0.02756877460315332 / 0.0011473580213809565 / 0.0021134470829949274 | 0.006430399709476225 / 1.3130360508344227e-05 / 0.014111760701313713 |
| 138 | CD151_3 | 11_836023_C_T / 11_836227_A_G / 11_835877_C_T | 0.031310628277621426 / 0.01189492161114428 / 0.0465236859230004 | 0.004311678571283407 / 0.001633994415617101 / 0.005759250847020773 |
| 139 | MBD2_2 | 18_54204938_G_A / 18_54224621_A_C | 0.032527518290623295 / 0.02387217907579878 | 0.007481293790069707 / 0.0024467066581282037 |
| 140 | ACAP1_2 | 17_7350305_C_T / 17_7343627_T_G | 0.03440244080220003 / 9.989468867792128e-05 | 0.009955377908509965 / 0.02484432576482206 |
| 141 | RHPN2_4 | 19_33002924_G_A / 19_33044231_A_G / 19_33044540_A_C / 19_33011638_C_G | 0.03758598191114063 / 6.498164345874758e-05 / 0.0019234652198936038 / 0.0005607094271426628 | 0.001694407500706198 / 0.0003445437417821702 / 0.0007353894363862997 / 0.0002119158667786005 |
| 142 | RASSF2_3 | 20_4797919_T_G / 20_4784304_T_C / 20_4784247_T_G | 0.037902749156553485 / 0.011694257494444695 / 0.00032929741865870437 | 0.007153311060028534 / 0.0020239510039769416 / 0.0013542591543729706 |
| 143 | MYO1G_4 | 7_44965836_A_C / 7_44970706_A_C / 7_44964431_G_T / 7_44979051_A_C | 0.04191223689634028 / 0.01979144289427551 / 0.00017645318680118606 / 0.041733273291402466 | 0.007221347246269528 / 0.002699507313002306 / 0.005180419499391653 / 0.0010403929060933288 |
| 144 | PIK3CD_4 | 1_9720778_T_G / 1_9720785_A_G / 1_9719895_T_G / 1_9718938_A_G | 1.0253516427976307e-05 / 0.0046476512085552105 / 0.00011802831952668278 / 0.006759908616419049 | 0.0012148539768169404 / 0.0398063487615097 / 0.0044497374818740715 / 0.04703097613769788 |
| 145 | PTGR1_2 | 9_111594107_A_G / 9_111578959_GAA_G | 1.5065359948490627e-06 / 0.005936401163136037 | 0.00764869645742515 / 0.03809849817293055 |
| 146 | SH3D19_3 | 4_151122202_T_C / 4_151148202_G_T / 4_151175208_T_G | 2.2029420860104835e-05 / 0.0016057485146252267 / 0.0049299501495510155 | 0.00026537095134489047 / 0.004030165987762314 / 0.036616308047703286 |
| 147 | DTNBP1_2 | 6_15662698_A_G / 6_15662701_T_G | 2.9366152452741533e-06 / 0.0006517798782510246 | 0.0063060334020981846 / 0.001004314451212422 |
| 148 | ZNRD1_3 | 6_30062280_G_A / 6_30062358_G_A / 6_30062412_T_A | 3.654974597084793e-05 / 1.1618445697892011e-05 / 0.0003334426304369216 | 0.006713962039550535 / 0.011500969330972352 / 0.02821821301850212 |
| 149 | SPATS2L_7 | 2_200329386_C_A / 2_200412288_CT_C / 2_200329511_A_C / 2_200412421_T_G / 2_200412425_T_G / 2_200477943_T_G / 2_200473083_GAA_G | 4.207550681496029e-05 / 0.0004415561732387749 / 2.0249110903712733e-05 / 6.324482115669083e-05 / 0.00042055460201680485 / 1.4403669192542887e-05 / 0.007061797305907755 | 0.0033487592228469143 / 0.011019446375268936 / 0.02491924164389806 / 0.03547678698863923 / 0.024316311222524558 / 0.016080388811817628 / 0.0009052273948575811 |
| 150 | ELOVL5_4 | 6_53295600_A_G / 6_53295602_T_G / 6_53291875_T_C / 6_53291854_T_G | 4.333948606334787e-05 / 9.154580881914281e-06 / 0.002303807174924029 / 0.010895023484809672 | 0.0008036056664569972 / 0.0007993551420952537 / 0.0030362229822457412 / 0.005396507263205953 |
| 151 | AGER_6 | 6_32183680_C_G / 6_32183336_A_C / 6_32180626_G_C / 6_32182537_A_C / 6_32182532_A_C / 6_32180983_T_G | 4.3474785520824183e-07 / 0.0008401867950240421 / 0.00012577188862559035 / 7.864018103130946e-05 / 0.0001383347487645318 / 0.0006412069737516832 | 0.026487158302874552 / 0.0008365781303084246 / 0.018710849801424196 / 0.024237923466307005 / 0.005092878554310726 / 0.028565251544064637 |
| 152 | KLHL18_3 | 3_47319581_T_G / 3_47344095_C_A / 3_47319585_T_G | 5.8893512793953086e-05 / 0.003560559459732024 / 0.0014314792247920815 | 0.013218876001835087 / 0.0063137500959640856 / 0.0442868915202707 |
| 153 | RBM6_6 | 3_50054242_G_T / 3_50054246_C_T / 3_50054250_C_T / 3_50054257_G_T / 3_50054263_T_G / 3_50066429_G_T | 9.610797412978416e-06 / 0.0004692267600390496 / 0.001169115137001947 / 0.016014825049119413 / 0.00038946159538077817 / 6.545113568163317e-06 | 0.0124136469122058 / 0.0004024483543288937 / 3.272618868931358e-05 / 5.8729619078742086e-05 / 0.00033057063887385755 / 0.0016854676901857401 |
[표 20]에는 MITOSIS 약물에 연관된 바이오마커와 이에 의한 약물의 반응성(P-value) 정도가 표로 도시되어 있다.
[표 20]에서 FRH는 『FRH명칭_포함된 마커수』형태로 표시되었고, 『Var_Drug(pval)』는 해당 마커가 약물의 반응성에 미치는 상관도(P-vlaue)값을 의미하는 것으로, 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있으며, 『Var_Exp(pval)』는 각 마커가 해당 유전자 발현에 미치는 상관도(Pvlaue)값을 의미하는 것으로, 이 역시 마커의 순서에 따라 각 약물에 대한 반응성 상관도 값이 구분인자 『/』로 구분되어 정리되어 있다.
이들 반응성 검증결과로부터, Var_Drug(pval) 및 Var_Exp(pval)이 낮을수록, 해당 마커가 약물 반응성을 판단하기 위한 바이오마커로 실효성이 높은 것으로 판단할 수 있다.
한편, 도 42에는 [표 20]에 기재된 바이오마커들 중 주요 바이오마커들의 MITOSIS 약물들에 대한 상관도(P-vlaue)값들이 그래프로 표시되어 있다.
| No. | FRH | Variants(마커) | Var_Drug(pval) | Var_Exp(Pval) |
| 1 | CYR61_1 | 1_85581605_TA_T | 5.27E-05 | 0.000620768 |
| 2 | MYB_1 | 6_135201764_A_C | 0.000110474 | 0.008038119 |
| 3 | MYH9_1 | 22_36302635_A_C | 0.000236116 | 0.040823397 |
| 4 | SNX24_1 | 5_123023772_TA_T | 0.00028033 | 0.010215104 |
| 5 | CHAF1A_1 | 19_4442532_T_C | 0.000284751 | 0.010330163 |
| 6 | CASP8AP2_1 | 6_89846678_CT_C | 0.000313931 | 0.000126501 |
| 7 | MTF2_1 | 1_93137118_TA_T | 0.000462823 | 0.036903175 |
| 8 | EGFR_1 | 7_55170771_T_G | 0.000668389 | 0.004588325 |
| 9 | ACVR1_1 | 2_157799371_CA_C | 0.000905558 | 0.016548442 |
| 10 | MED12_1 | X_71132797_T_C | 0.000941588 | 0.024279673 |
| 11 | TRA2B_1 | 3_185921167_T_C | 0.001087771 | 0.003158761 |
| 12 | CYB5R3_1 | 22_42619486_G_T | 0.001094814 | 0.002582708 |
| 13 | NFX1_1 | 9_33303208_A_G | 0.001100893 | 0.023431449 |
| 14 | UACA_1 | 15_70669470_GA_G | 0.001412253 | 0.03571568 |
| 15 | MOK_1 | 14_102304907_T_C | 0.001776612 | 0.001629205 |
| 16 | RNF138_1 | 18_32123591_T_C | 0.001798779 | 0.018606829 |
| 17 | NMT2_1 | 10_15119275_A_C | 0.002227268 | 0.015194231 |
| 18 | DLG2_1 | 11_83980458_A_G | 0.002667354 | 0.014824348 |
| 19 | RIN2_1 | 20_19990244_G_A | 0.002695061 | 0.013004393 |
| 20 | DHX15_1 | 4_24540080_CT_C | 0.003782084 | 0.012007783 |
| 21 | CD276_1 | 15_73702902_T_G | 0.00386155 | 0.020273648 |
| 22 | HDAC2_1 | 6_113944423_T_C | 0.004344928 | 0.041935697 |
| 23 | PIAS4_1 | 19_4039058_G_C | 0.005375712 | 0.037776153 |
| 24 | ARHGAP15_1 | 2_143216291_G_A | 0.005719356 | 0.035966273 |
| 25 | STRBP_1 | 9_123266116_C_G | 0.006459968 | 0.001078377 |
| 26 | MYO1C_1 | 17_1484178_C_T | 0.007569353 | 0.007802374 |
| 27 | EPB41_1 | 1_29015578_GA_G | 0.007616579 | 0.046541231 |
| 28 | PRDM2_1 | 1_13823349_T_A | 0.00796288 | 0.011003429 |
| 29 | MDM4_1 | 1_204536848_GA_G | 0.008010095 | 0.021420681 |
| 30 | C1R_1 | 12_7091679_A_C | 0.00873535 | 0.0246229 |
| 31 | RGS16_1 | 1_182600365_T_G | 0.009039587 | 0.036240935 |
| 32 | KIFC3_1 | 16_57765532_T_G | 0.009062011 | 0.038497261 |
| 33 | NOTCH2_1 | 1_119922384_T_A | 0.009876287 | 0.022769433 |
| 34 | PRPF38A_1 | 1_52416794_T_G | 0.012365097 | 0.004382879 |
| 35 | U2AF1_1 | 21_43093000_GT_G | 0.018718881 | 0.003527509 |
| 36 | FNDC3B_1 | 3_172328905_GT_G | 0.019450759 | 1.78E-05 |
| 37 | ITPRIPL1_1 | 2_96325641_T_G | 0.024457637 | 0.004828474 |
| 38 | PRKCB_1 | 16_24174494_CT_C | 0.029704271 | 0.000670802 |
| 39 | GMEB1_1 | 1_28702335_T_A | 0.031116839 | 0.003887013 |
| 40 | IL6ST_1 | 5_55960635_CT_C | 0.045023867 | 0.00567988 |
| 41 | SRGAP1_1 | 12_64142411_T_C | 0.046097342 | 0.006505853 |
| 42 | DNMT1_1 | 19_10162649_G_A | 0.048749303 | 0.001347433 |
| 43 | NPC1_2 | 18_23540944_CT_C / 18_23539283_G_A | 0.00011218638512848764 / 6.166244499849825e-05 | 0.040822963170832685 / 0.020956228007299703 |
| 44 | KDM2B_2 | 12_121579943_C_CA / 12_121534367_T_A | 0.0002469480356989407 / 0.00024928370737718086 | 0.01794421156168876 / 0.01671856514998881 |
| 45 | MET_3 | 7_116740945_T_G / 7_116757685_T_G / 7_116795676_T_G | 0.00037055097855276256 / 0.003772251227706767 / 0.04454843008676103 | 0.00017295700570667475 / 5.0554093231126755e-05 / 0.0006156874780574698 |
| 46 | WWTR1_2 | 3_149669685_C_T / 3_149669894_G_A | 0.0006147608436462098 / 0.0050779807840600905 | 0.040303211258058205 / 0.014886977556994025 |
| 47 | RPRD2_2 | 1_150470594_A_C / 1_150473591_C_T | 0.0006254084658607492 / 0.029513176305296374 | 0.04999439760188915 / 0.008299610316019734 |
| 48 | PHIP_9 | 6_78946845_A_T / 6_78965984_A_G / 6_78947674_G_A / 6_78954723_T_C / 6_78955493_T_A / 6_78969860_A_G / 6_78985312_C_T / 6_78998206_C_T / 6_79043075_T_C | 0.0007025290839441325 / 0.0008446291153155781 / 0.010121938819521418 / 0.017201835088518632 / 0.014930588444064525 / 0.02454094082336056 / 0.009915783788926756 / 0.0023583595976247713 / 0.011026610846676282 | 0.0325055100647953 / 0.0325055100647953 / 0.0010048550446085317 / 0.00648756713202656 / 0.009594339103514994 / 0.0017203137452171692 / 0.0007527047164367361 / 0.006763071535609179 / 0.0016364259457283912 |
| 49 | USP37_2 | 2_218485635_CAAAA_C / 2_218455538_T_G | 0.0008931966771009113 / 0.00047307780771944745 | 0.04869664909579453 / 0.006248282014078397 |
| 50 | RRAS_3 | 19_49636811_C_T / 19_49636835_G_A / 19_49636989_C_A | 0.0012180086241795427 / 0.0008453114718541902 / 0.00389443225116509 | 0.011066495702872568 / 0.008806050890865063 / 0.010977696307794636 |
| 51 | SHPRH_7 | 6_145910334_C_A / 6_145922445_C_T / 6_145923607_A_G / 6_145947487_T_A / 6_145948270_A_C / 6_145955343_T_G / 6_145922945_GT_G | 0.0015751671472739686 / 0.008305307007300559 / 0.003356044877090312 / 0.00413644978183887 / 0.009574107378650136 / 0.0002467850170635296 / 0.0028322412885894953 | 0.0007641881109242402 / 0.0008695206428685066 / 0.0004025103622500861 / 0.0002754715942379004 / 0.020534325332750382 / 0.0019437040989644704 / 0.0032085441168495693 |
| 52 | LAMB2_2 | 3_49132472_A_C / 3_49126013_T_G | 0.0017423458459882547 / 0.041025181157896495 | 0.0019625130257961386 / 0.002569958840604656 |
| 53 | THRAP3_2 | 1_36288866_G_C / 1_36282396_ATTT_A | 0.0020512788997300887 / 0.0016248690625818355 | 0.0001317384338547229 / 0.04220913139330165 |
| 54 | CTNNA1_2 | 5_138932696_A_G / 5_138932714_T_G | 0.002692413567981528 / 0.005472909098268261 | 0.007557173168109447 / 0.0016091365079487266 |
| 55 | TAPT1_2 | 4_16162866_G_A / 4_16202603_GA_G | 0.002918386893883101 / 0.000914379509289869 | 0.000763966557961968 / 0.0004886648390188492 |
| 56 | SLC35F5_3 | 2_113717856_GA_G / 2_113742699_CA_C / 2_113723196_TA_T | 0.003014076668232333 / 0.005012402765669162 / 0.0170410099009839 | 0.01701812431912492 / 6.159712513106605e-06 / 0.009792441988171948 |
| 57 | CCAR1_3 | 10_68737016_C_A / 10_68747145_CT_C / 10_68760969_CT_C | 0.00325467857819848 / 0.025692165325181263 / 0.0016743825966123902 | 0.003954046326130957 / 0.007417608363424872 / 0.007417608363424872 |
| 58 | TADA1_2 | 1_166858437_T_C / 1_166869276_TA_T | 0.003257661220538658 / 0.007643004397209361 | 0.012600985482671512 / 0.00358370659710894 |
| 59 | SAFB_2 | 19_5668433_GT_G / 19_5653276_T_G | 0.0039066263073592 / 0.0014480393694902619 | 0.0026106809691974946 / 0.018733735357902476 |
| 60 | LEPROTL1_2 | 8_30105682_AT_A / 8_30156243_A_C | 0.005708636597504029 / 0.014522072472209685 | 0.02256500634957293 / 3.3209275234199355e-06 |
| 61 | SQSTM1_3 | 5_179833009_G_A / 5_179822433_T_C / 5_179832842_G_C | 0.005980563650762417 / 9.139203270628232e-06 / 0.04751023288058377 | 0.03979973429187952 / 0.0024949336391905503 / 0.0024314650981475784 |
| 62 | PLEC_10 | 8_143935900_T_G / 8_143916360_A_G / 8_143917054_T_G / 8_143918739_A_C / 8_143919099_A_G / 8_143975295_A_G / 8_143919088_C_G / 8_143925285_C_T / 8_143927138_G_A / 8_143930017_C_T | 0.006797512530240399 / 0.023847093097519808 / 0.003689478164571844 / 0.04007075765894598 / 0.03700251313887589 / 0.004544202282444686 / 0.03720602259473315 / 0.00047050570860322235 / 4.768364655899894e-05 / 0.0001893462141118206 | 0.0004960012901022363 / 0.00910116635228719 / 0.025072704488480143 / 2.138708286444241e-05 / 0.0010288222361061275 / 0.039226625991533134 / 0.009415988048366521 / 0.005460087145469642 / 0.008162873576760793 / 0.001268625363946227 |
| 63 | CTSA_2 | 20_45893486_C_CT / 20_45894873_G_C | 0.006806775220314732 / 0.009189197205389115 | 0.0011092438036515453 / 2.1137755776974608e-05 |
| 64 | RND3_2 | 2_150471770_GA_G / 2_150487464_GA_G | 0.006850825677580675 / 0.002608896214858801 | 0.004413096667547799 / 0.009852344084866441 |
| 65 | DOCK1_3 | 10_127409601_G_A / 10_127248143_T_C / 10_127248024_G_T | 0.0069346786852210966 / 0.001954876992257982 / 0.00010052759289672492 | 0.021839153568346648 / 0.030500963727912844 / 0.020184142497530616 |
| 66 | MYOF_2 | 10_93341723_C_T / 10_93379679_T_C | 0.007420864833221702 / 0.007547951219247403 | 1.0154009952651607e-05 / 0.0006543495060757152 |
| 67 | PDS5B_2 | 13_32758091_C_T / 13_32675925_C_A | 0.0075589035603876795 / 0.0017607048342993868 | 0.0023301391981286807 / 0.004241708828197667 |
| 68 | HEXB_3 | 5_74696784_G_A / 5_74715459_CT_C / 5_74715716_T_A | 0.007745014587458687 / 4.786425040147315e-06 / 8.479985392616748e-06 | 0.037654298343869685 / 0.0009700644073606587 / 0.0006894634360309071 |
| 69 | TANC1_2 | 2_159136061_C_T / 2_159174959_G_C | 0.00802472531176929 / 0.006460757964179747 | 0.017357470848779515 / 0.02749828370491698 |
| 70 | ASPH_2 | 8_61642872_G_A / 8_61638365_TA_T | 0.009092096160092012 / 2.1941312888430133e-05 | 9.242250914202104e-05 / 0.0033421074285719613 |
| 71 | GSN_2 | 9_121326794_T_G / 9_121318750_T_C | 0.009209877230841344 / 0.005427091425517584 | 0.014858234163842209 / 0.01549301533305157 |
| 72 | ZNF292_3 | 6_87258847_A_G / 6_87260583_C_G / 6_87257934_G_C | 0.0095880085401273 / 0.002653056510702511 / 0.037301685006945806 | 0.03664575782437445 / 0.02762172574455939 / 1.3565314335396872e-05 |
| 73 | DTNBP1_2 | 6_15662660_G_A / 6_15651411_GA_G | 0.016540725603977957 / 0.0034858875216863218 | 0.005994085134454578 / 0.0014349866138238813 |
| 74 | SUGP2_2 | 19_19025732_C_T / 19_19008374_A_C | 0.023033529177264773 / 0.0007995182905667767 | 0.008182273259557721 / 0.003040780848236827 |
| 75 | ARID1B_5 | 6_157084627_G_A / 6_157084796_G_A / 6_156935454_GT_G / 6_156779132_C_G / 6_157206255_A_C | 0.023572130650620228 / 0.0065953837312734045 / 0.00024483625735866694 / 0.0017474661626312965 / 0.008386743713695547 | 0.002480449952777213 / 0.003319459056638543 / 0.031030935390966245 / 0.0436791475273224 / 0.02302848816217332 |
| 76 | DAZAP1_3 | 19_1432575_T_C / 19_1432578_A_C / 19_1421326_T_G | 0.025717426655995912 / 0.012380456372647609 / 0.005697517435006497 | 0.008783799588482919 / 0.004625103934387489 / 0.03399063425366008 |
| 77 | FAM76B_2 | 11_95786079_T_C / 11_95787545_T_C | 0.026712661661121014 / 0.007093482411673812 | 0.008842917440325095 / 0.006738523037696958 |
| 78 | CNTRL_3 | 9_121175323_T_C / 9_121167492_C_T / 9_121123912_AT_A | 0.02777922136116125 / 0.03429035595633583 / 0.009987376618823514 | 0.008182636643218607 / 0.0016137010941682265 / 0.04001035208622377 |
| 79 | IQCB1_4 | 3_121788384_A_T / 3_121807190_T_G / 3_121781663_A_T / 3_121781662_C_A | 0.02873631298848243 / 0.04311975747619515 / 0.0034541658078948746 / 0.0008249500332497977 | 0.0011523884052119758 / 0.0035712731344638405 / 0.03680371502100786 / 0.031208890653500118 |
| 80 | RRBP1_2 | 20_17636886_T_C / 20_17643440_G_A | 0.03507251839152679 / 0.01991260739356573 | 1.9056892828600246e-06 / 0.0037236305333221867 |
| 81 | ZNF84_2 | 12_133048690_A_T / 12_133048009_C_G | 0.037210990330289934 / 0.040160599243354515 | 0.0028259388562976405 / 0.008314464537214374 |
| 82 | MYCBP2_2 | 13_77098982_T_G / 13_77061586_T_C | 0.03744183774757608 / 0.00310540257860121 | 0.0038229074053839733 / 0.030373685856290068 |
| 83 | CALD1_3 | 7_134933124_A_G / 7_134891710_CTT_C / 7_134941283_GAAA_G | 1.0681523332046643e-06 / 0.0055155972985149685 / 0.0008159520917689481 | 0.034156156662500686 / 0.006749784168432884 / 0.007042501841739691 |
| 84 | RBMX_5 | X_136874303_G_C / X_136874308_C_T / X_136876571_C_A / X_136880660_G_A / X_136879426_ATG_A | 5.449363562924237e-05 / 3.4887046700057416e-07 / 6.172396284131506e-05 / 0.0054727241117358974 / 0.005573036956662709 | 0.0383480406291467 / 0.029837740684056712 / 0.015245783387880662 / 0.03540981223032282 / 0.0056729536604581 |
| 85 | POLR2B_3 | 4_57005538_CA_C / 4_57023798_AT_A / 4_57024870_CT_C | 5.482928793734288e-06 / 0.02167722586394588 / 0.0009543180256774695 | 0.018564114826717992 / 0.007472844031288456 / 0.0012756499136273938 |
| 86 | SECISBP2_3 | 9_89319872_A_G / 9_89325866_A_T / 9_89348180_T_G | 6.195560569127674e-05 / 0.0006584940331716795 / 0.0021577193257759702 | 0.020014055406942226 / 0.00642217291639139 / 0.01739212501206905 |
| 87 | FBXO41_2 | 2_73258961_C_G / 2_73264474_A_C | 7.08184621839895e-05 / 0.008886058285019023 | 0.010646018841909207 / 0.014910469893708134 |
| 88 | TSPAN4_2 | 11_844057_C_G / 11_865650_C_G | 8.251559449584364e-05 / 0.0042898689776822594 | 0.04166717005266338 / 0.02401170518473186 |
한편, 도 23에는 [표 1]에서 정리한 6개 암타입과 [표 14]에서 정리한 6개 약물타입에 대한 약물의 동반진단을 위한 바이오마커 검출에 사용되는 검사칩을 제작하는 방법이 도시되어 있다.
도 23에 도시된 바와 같이, 제1단계에서, [표 1] 및 [표 14]에 특정된 암타입 및 약물타입에 대한 각 바이오마커들에 대한 진단칩을 제작하거나, 상기 암타입 및 약물타입에 대한 모든 바이오마커만들거나 혹은 전체 을 모두 하나의 칩을 제작하고, 환자로부터 약물타입 또는 암타입과 관련된 FRH 마커에 대하여, 도 18의 도시된 실시예(혈액암의 약물타입 중의 하나인 EGFR pathway) 약물반응과 연관이 높은 한 세트의 FRH 및 특정암에 연관성이 높은 전체 FRH를 사용하여, 도 20의 Linear Regression 예측모델을 생성하는 형식으로 약물반응성을 예측할 수 있다. 따라서, 본 특허에서 정리한 6개 암타입(CancerClass) 및 6개 약물타입(DrugClass)에 특이한 FRH 바이오마커들을 이용하여 다양한 암 및 암약물 동반진단 칩을 도 23처럼 제작하여 활용할 수 있다.
마지막으로, 본 발명의 대상인 CHROMATIN 약물에 대한 반응성 판단을 위한, 바이오 마커 조성물에 대하여 요약하면, [표 16]에 개시된 각각의 마커들이 유의성 있는 것으로 산출되었고, 이들 마커 중 SPR 유전자 발현과 연관된 마커 2_72891611_A_C 및 ERRFI1 유전자 발현과 연관된 마커 1_8013331_A_G 가 주요한 마커 조합으로 판단되었다.
물론, 본 발명에 의한 바이오 마커 조성물은 이와 더불어 [표 21]에 정리된 추가적인 주요 바이오 마커들을 더 포함하여 다양한 조합에 의해 구성될 수 있다.
| No. | FRH | Variants(마커) |
| 1 | BCL9L_1 | 11_118897861_A_C |
| 2 | ZDHHC7_1 | 16_84981848_T_G |
| 3 | CCDC69_1 | 5_151185396_T_C |
| 4 | DDX60_1 | 4_168220820_G_T |
| 5 | RASSF5_1 | 1_206507640_A_C |
| 6 | C21orf58_1 | 21_46302477_A_G |
| 7 | KIAA0922_1 | 4_153466445_G_C |
| 8 | NR2F2_1 | 15_96331144_C_T |
| 9 | WWC2_1 | 4_183261395_G_T |
| 10 | KIAA1191_1 | 5_176361895_T_C |
| 11 | QSOX1_1 | 1_180196892_T_G |
| 12 | NTN4_1 | 12_95683554_A_C |
| 13 | KIFC3_1 | 16_57765532_T_G |
| 14 | LPP_1 | 3_188484677_T_G |
| 15 | TUFT1_1 | 1_151565936_G_A |
| 16 | CDC14B_1 | 9_96496393_T_TACC |
| 17 | DTX1_1 | 12_113093500_A_T |
| 18 | P4HA2_1 | 5_132227207_C_T |
| 19 | ARHGAP25_1 | 2_68818005_T_G |
| 20 | TIMM13_1 | 19_2425296_G_C |
| 21 | CAST_1 | 5_96741643_A_C |
| 22 | PTPN12_1 | 7_77627576_G_C |
| 23 | MED28_1 | 4_17614675_T_G |
| 24 | SLC35F5_1 | 2_113723196_TA_T |
| 25 | TPBG_1 | 6_82364929_T_C |
| 26 | CD79B_1 | 17_63932334_A_C |
| 27 | DIRC2_1 | 3_122856322_A_G |
| 28 | UEVLD_1 | 11_18558312_C_A |
| 29 | LRP10_1 | 14_22875577_A_C |
| 30 | UGDH_1 | 4_39504307_CA_C |
| 31 | VMP1_1 | 17_59841357_A_C |
| 32 | DOT1L_1 | 19_2190948_TTGG_T |
| 33 | OSMR_1 | 5_38933647_C_T |
| 34 | CYR61_1 | 1_85581605_TA_T |
| 35 | EMP1_1 | 12_13211531_T_G |
| 36 | PRDM2_1 | 1_13781628_C_T |
| 37 | UBE2N_1 | 12_93411182_C_T |
| 38 | PDE7A_1 | 8_65724444_TATAA_T |
| 39 | ZNF775_1 | 7_150397765_G_A |
| 40 | ACSS2_1 | 20_34920910_T_G |
| 41 | TNRC6C_1 | 17_78049826_A_C |
| 42 | OPTN_1 | 10_13108909_T_C |
| 43 | FHL2_1 | 2_105398737_G_C |
| 44 | TSR2_1 | X_54440646_T_G |
| 45 | PON2_1 | 7_95406313_A_C |
| 46 | RIN2_1 | 20_19990244_G_A |
| 47 | ACVR1_1 | 2_157780624_GA_G |
| 48 | ARRB2_1 | 17_4720324_T_G |
| 49 | STRBP_1 | 9_123266116_C_G |
| 50 | APLP2_1 | 11_130110790_G_A |
| 51 | PPM1D_1 | 17_60656555_C_G |
| 52 | MICALL2_1 | 7_1442358_T_G |
| 53 | SDC4_1 | 20_45330303_T_G |
| 54 | MAP4K1_1 | 19_38617327_T_G |
| 55 | DDX51_1 | 12_132144264_G_A |
| 56 | CD63_1 | 12_55725568_A_C |
| 57 | TSEN34_1 | 19_54192354_T_G |
| 58 | RND3_1 | 2_150487464_GA_G |
| 59 | DYNC1LI2_1 | 16_66723584_GTTT_G |
| 60 | ATG4D_1 | 19_10547046_A_G |
| 61 | TEAD4_1 | 12_3019250_C_T |
| 62 | SPATS2L_1 | 2_200329386_C_A |
| 63 | TCF3_1 | 19_1627423_T_C |
| 64 | GPX8_1 | 5_55164338_T_C |
| 65 | CHD7_1 | 8_60781091_A_C |
| 66 | IQCB1_1 | 3_121788568_C_T |
| 67 | CD84_2 | 1_160549875_A_G / 1_160550877_C_G |
| 68 | GSN_2 | 9_121300011_T_G / 9_121321305_A_C |
| 69 | PTPRC_2 | 1_198703381_A_C / 1_198752063_T_C |
| 70 | DAG1_2 | 3_49531399_T_G / 3_49530812_A_G |
| 71 | CLEC16A_3 | 16_11156556_C_A / 16_11060913_G_A / 16_11042191_C_G |
| 72 | SEMA3C_2 | 7_80748927_A_C / 7_80758439_T_G |
| 73 | MYO1E_3 | 15_59272288_G_C / 15_59223315_G_A / 15_59138181_A_C |
| 74 | FBRSL1_2 | 12_132582046_C_T / 12_132490757_A_G |
| 75 | PLAUR_2 | 19_43665377_C_A / 19_43665506_A_C |
| 76 | UPP1_2 | 7_48108129_C_G / 7_48108147_T_G |
| 77 | TM4SF1_3 | 3_149375338_T_G / 3_149375342_T_G / 3_149375345_A_G |
| 78 | ZNF430_4 | 19_21020746_C_T / 19_21022725_C_T / 19_21034405_A_G / 19_21022773_T_G |
| 79 | CYTIP_2 | 2_157427544_C_T / 2_157427198_A_G |
| 80 | FAM129B_3 | 9_127531490_GA_G / 9_127525143_T_G / 9_127578821_C_G |
| 81 | SEC11C_2 | 18_59152698_T_C / 18_59139887_T_G |
| 82 | SERPINB6_3 | 6_2955641_A_C / 6_2955644_A_C / 6_2959401_A_C |
| 83 | HEXB_5 | 5_74696581_T_G / 5_74696784_G_A / 5_74715459_CT_C / 5_74715716_T_A / 5_74715716_T_TA |
| 84 | CHAF1A_5 | 19_4431899_C_T / 19_4442339_C_T / 19_4443049_T_C / 19_4422720_A_G / 19_4442532_T_C |
| 85 | DTNBP1_5 | 6_15522870_T_C / 6_15662701_T_G / 6_15524467_T_C / 6_15637909_C_A / 6_15651411_GA_G |
| 86 | NPC1_6 | 18_23533587_A_G / 18_23531466_TG_T / 18_23543332_G_GA / 18_23556539_A_C / 18_23551637_T_C / 18_23540944_CT_C |
| 87 | DCK_2 | 4_71023678_G_A / 4_71023683_A_T |
| 88 | MYOF_5 | 10_93402739_A_T / 10_93341723_C_T / 10_93456833_C_T / 10_93359764_G_A / 10_93379679_T_C |
| 89 | CNOT6L_4 | 4_77720488_T_G / 4_77819455_A_C / 4_77720486_A_G / 4_77726534_A_C |
| 90 | SNX24_2 | 5_122845530_G_A / 5_123023772_TA_T |
| 91 | SQSTM1_4 | 5_179833153_C_T / 5_179833213_G_A / 5_179822433_T_C / 5_179832842_G_C |
| 92 | CTTN_7 | 11_70419876_A_C / 11_70419880_T_C / 11_70433755_A_G / 11_70433765_G_C / 11_70407283_C_T / 11_70433037_T_G / 11_70435435_C_T |
| 93 | KDM2B_4 | 12_121580903_A_C / 12_121579943_C_CA / 12_121444386_T_G / 12_121580252_TG_T |
| 94 | CTNNA1_4 | 5_138812304_T_G / 5_138824633_A_C / 5_138933920_C_T / 5_138812289_C_G |
| 95 | TRIOBP_2 | 22_37751927_A_C / 22_37757383_C_G |
| 96 | EGR1_2 | 5_138467153_A_C / 5_138466811_A_C |
| 97 | MYCBP2_8 | 13_77070727_G_A / 13_77165156_A_T / 13_77098982_T_G / 13_77051091_G_A / 13_77051098_A_C / 13_77058230_T_G / 13_77061586_T_C / 13_77267898_T_G |
| 98 | TCF4_6 | 18_55464257_C_A / 18_55463971_TGTGTGTGA_T / 18_55275657_A_G / 18_55275664_A_G / 18_55403517_A_C / 18_55461237_G_T |
| 99 | LAMC1_3 | 1_183132309_A_C / 1_183131203_C_T / 1_183131172_CAA_C |
| 100 | DCBLD2_2 | 3_98800637_G_A / 3_98822022_G_A |
| 101 | FAM114A1_2 | 4_38905545_G_A / 4_38905553_A_G |
| 102 | RXRA_2 | 9_134379472_C_A / 9_134432274_T_C |
| 103 | TXNL4A_2 | 18_80033872_T_C / 18_79988525_A_C |
| 104 | PLOD1_3 | 1_11957799_T_G / 1_11958607_A_C / 1_11949823_T_G |
| 105 | ZBTB40_2 | 1_22508509_T_G / 1_22490438_G_C |
| 106 | LAMB1_4 | 7_107937003_CT_C / 7_107937011_T_C / 7_107932321_G_T / 7_107962914_G_C |
| 107 | ZNF407_2 | 18_74635526_T_C / 18_74631665_A_C |
| 108 | PLK2_2 | 5_58457156_TA_T / 5_58459186_CA_C |
| 109 | ITGAV_6 | 2_186622542_G_T / 2_186637080_T_G / 2_186637084_A_G / 2_186602110_C_T / 2_186665096_ATTT_A / 2_186665096_ATTT_AT |
| 110 | TPP2_4 | 13_102649187_G_T / 13_102654868_C_T / 13_102663598_G_C / 13_102663763_G_A |
| 111 | EGFR_2 | 7_55205133_G_A / 7_55205662_A_C |
| 112 | FAM57A_2 | 17_733080_T_TCTC / 17_733026_A_AGGGCC |
| 113 | RBFOX1_2 | 16_7676807_A_C / 16_7653705_T_G |
| 114 | PLEC_10 | 8_143935900_T_G / 8_143916360_A_G / 8_143917054_T_G / 8_143917234_T_G / 8_143918739_A_C / 8_143919099_A_G / 8_143925385_A_C / 8_143919088_C_G / 8_143927138_G_A / 8_143930017_C_T |
| 115 | ACTN1_2 | 14_68904620_A_G / 14_68879945_C_A |
| 116 | YES1_2 | 18_724697_A_C / 18_732727_A_G |
| 117 | SMARCC1_2 | 3_47662444_T_G / 3_47735913_C_T |
| 118 | LMNA_2 | 1_156139242_AT_A / 1_156138783_A_G |
| 119 | CCND1_2 | 11_69650913_A_G / 11_69651969_C_G |
| 120 | SMARCA4_3 | 19_11025539_C_G / 19_11025639_C_T / 19_11059900_G_C |
| 121 | KMT2C_7 | 7_152273692_G_A / 7_152235860_C_T / 7_152145265_T_G / 7_152152848_C_A / 7_152177504_T_G / 7_152236218_G_A / 7_152152869_A_G |
| 122 | PXN_2 | 12_120219856_A_C / 12_120219864_A_C |
| 123 | BCOR_2 | X_40052275_A_C / X_40074609_T_G |
| 124 | FLI1_2 | 11_128810729_A_G / 11_128810736_G_C |
| 125 | LAMB2_4 | 3_49121431_A_C / 3_49126013_T_G / 3_49125146_T_G / 3_49121239_T_G |
| 126 | HMGA2_2 | 12_65841991_CT_C / 12_65838525_G_A |
| 127 | ZNF708_3 | 19_21294577_C_T / 19_21309149_T_A / 19_21309260_G_A |
| 128 | ASPH_2 | 8_61578734_T_G / 8_61578968_A_C |
| 129 | CCAR1_5 | 10_68737016_C_A / 10_68736998_A_C / 10_68747386_A_C / 10_68749170_A_C / 10_68747145_CT_C |
| 130 | DOCK1_3 | 10_127008567_ATAACT_A / 10_127248024_G_T / 10_127414990_T_G |
여기서, FRH는 발현 유전자를 나타내고, FRH에 부가되어 표시된 숫자는 각 발현 유전자에 연관된 마커의 개수를 의미한다.
용어의 설명
본 발명에서 약물타입(DrugClass)에 대한 정의는 약물 표적들의 타입(type) 및 약물의 관능기적 유사한 기능 타입, 혹은, 약물이 영향을 주는 범주의 유전자그룹, 약물 패스웨이(drug pathway) 혹은 약물 시그널링 패스웨이(drug signaling pathway), 등은 모두 하나의 통칭 약물타입(DrugClass)로 설명 하는 용어이다. FRH는 기능하프로타입(functionally related relative haplotype)을 나타내는 용어이고, eQTL은 발현에 대한 양적형질위치 (expression quantitative trait loci)을 나타내는 용어이며, FRH(Exp|IC50)는 과/저(over/under) 발현된 군집에 대한 IC50의 평균값을 나타내는 용어이고, FRH(CNV|IC50)는 증폭/삭제(amplification/deletion) 군집에 대한 IC50의 평균값을 나타내는 용어이며, FRH(loci|IC50)는 주어딘 loci타입 군집에 대한 IC50의 평균값을 나타내는 용어이고, GDSC는 Genomics of Drug Sensitivity in Cancer을 나타내는 용어이며, CCLP는 COSMIC Cell Lines Project을 나타내는 용어로 웹페이지 http://cancer.sanger.ac.uk/cell_lines로부터 확인할 수 있고, CNV는 복제수변이(Copy number variation)을 나타내는 용어이며, GBLscan는 암동반진단마커 스켄(Cancer Biomarker Labeling Scan)을 나타내는 용어이고, ISCT는 가상임상(In Silico Clinical Trial)을 나타내는 용어이다.
본 발명의 권리는 위에서 설명된 실시예에 한정되지 않고 청구범위에 기재된 바에 의해 정의되며, 본 발명의 분야에서 통상의 지식을 가진 자가 청구범위에 기재된 권리범위 내에서 다양한 변형과 개작을 할 수 있다는 것은 자명하다.
본 발명은 암을 포함하는 질병 관련 특이 유전자 변이 지문 (Genetic Variation Fingerprints)과 약물의 분자 약리관능기의 결합분석에 의해 약물의 반응성을 신뢰성 있게 예측할 수 있는 새로운 선형 회귀 모델인 약물 적응증 및 반응 예측 시스템 및 방법인 GBLscan (Genetic Biomarker Scan)에 관한 것으로, 본 발명에 의하면, 본 발명에서는 체외 및 체내 임상시험으로부터 수집되는 유전체에 대한 약물의 반응성 결과들로부터, 약리 효과가 밝혀지지 않은 유전체와 약물의 반응성 정도를 예측할 수 있는 효과가 있다.
Claims (9)
- CHROMATIN 약물에 대한 반응성 판단을 위하여, 유전자 발현을 조절하는 변이가 포함된 마커들의 조합으로 구성되는 바이오 마커 조성물에 있어서,
상기 바이오 마커 조성물은,
2_72891611_A_C(마커1) 및 1_8013331_A_G(마커2)를 포함하여 구성됨을 특징으로 하는 CHROMATIN 약물 반응성 판단을 위한 바이오 마커 조성물.
- 제 1 항에 있어서,
상기 바이오 마커 조성물은,
표 21에 기재된 마커들 중에서 어느 하나 이상의 마커를 더 포함하여 구성됨을 특징으로 하는 CHROMATIN 약물 반응성 판단을 위한 바이오 마커 조성물.
- 제 1 항 또는 제 2 항에 있어서,
상기 CHROMATIN 약물은,
Phenformin, AICA_Ribonucleotide 또는 Daporinad 중 어느 하나 이상을 포함함을 특징으로 하는 CHROMATIN 약물 반응성 판단을 위한 바이오 마커 조성물.
- CHROMATIN 약물에 대한 반응성 판단을 위하여, 유전자 발현을 조절하는 변이가 포함된 마커들의 조합으로 구성되는 바이오 마커 조성물을 검출하여, CHROMATIN 약물에 대한 반응성을 판단하는 방법에 있어서,
상기 바이오 마커 조성물은,
2_72891611_A_C(마커1) 및 1_8013331_A_G(마커2)를 포함하여 구성됨을 특징으로 하는 바이오 마커 조성물을 이용한 CHROMATIN 약물 반응성 판단 방법.
- 제 4 항에 있어서,
상기 바이오 마커 조성물은,
표 21에 기재된 마커들 중에서 어느 하나 이상의 마커를 더 포함하여 구성됨을 특징으로 하는 바이오 마커 조성물을 이용한 CHROMATIN 약물 반응성 판단 방법.
- 제 4 항 또는 제 5 항에 있어서,
상기 CHROMATIN 약물은,
Phenformin, AICA_Ribonucleotide 또는 Daporinad 중 어느 하나 이상을 포함함을 특징으로 하는 바이오 마커 조성물을 이용한 CHROMATIN 약물 반응성 판단 방법.
- CHROMATIN 약물에 대한 반응성 판단을 위하여, 유전자 발현을 조절하는 변이가 포함된 마커들의 조합으로 구성되는 바이오 마커 조성물을 검출하는 진단칩에 있어서,
검출대상인, 상기 바이오 마커 조성물은,
2_72891611_A_C(마커1) 및 1_8013331_A_G(마커2)를 포함하여 구성됨을 특징으로 하는 CHROMATIN 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩.
- 제 7 항에 있어서,
상기 바이오 마커 조성물은,
표 21에 기재된 마커들 중에서 어느 하나 이상의 마커를 더 포함하여 구성됨을 특징으로 하는 CHROMATIN 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩.
- 제 7 항 또는 제 8 항에 있어서,
상기 CHROMATIN 약물은,
Phenformin, AICA_Ribonucleotide 또는 Daporinad 중 어느 하나 이상을 포함함을 특징으로 하는 CHROMATIN 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20180124512 | 2018-10-18 | ||
| KR1020180124512 | 2018-10-18 | ||
| KR1020190096410A KR20200044677A (ko) | 2018-10-18 | 2019-08-07 | 암 약물 반응성 판단을 위한 바이오 마커, 이를 이용한 암 약물 반응성 판단 방법 및 이를 위한 암 약물 반응성 진단칩 |
| KR1020190096410 | 2019-08-07 | ||
| KR1020190098165A KR20200054058A (ko) | 2018-10-18 | 2019-08-12 | 암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 암 약물 반응성 판단 방법 및 암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
| KR1020190098165 | 2019-08-12 |
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| KR1020190098492A Division KR20200054059A (ko) | 2018-10-18 | 2019-08-13 | 암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 암 약물 반응성 판단 방법 및 암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
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| KR1020190098551A KR20200044680A (ko) | 2018-10-18 | 2019-08-13 | Chromatin 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 chromatin 약물 반응성 판단 방법 및 chromatin 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
| KR1020190098517A KR20200043891A (ko) | 2018-10-18 | 2019-08-13 | 두경부암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 두경부암 약물 반응성 판단 방법 및 두경부암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
| KR1020190098498A KR20200044678A (ko) | 2018-10-18 | 2019-08-13 | 여성암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 여성암 약물 반응성 판단 방법 및 여성암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
| KR1020190098577A KR20200044681A (ko) | 2018-10-18 | 2019-08-13 | Erk_mapk 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 erk_mapk 약물 반응성 판단 방법 및 erk_mapk 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
| KR1020190098597A KR20200044683A (ko) | 2018-10-18 | 2019-08-13 | Mitosis 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 mitosis 약물 반응성 판단 방법 및 mitosis 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
| KR1020190098585A KR20200044682A (ko) | 2018-10-18 | 2019-08-13 | Igfr 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 igfr 약물 반응성 판단 방법 및 igfr 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
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| KR1020190098517A KR20200043891A (ko) | 2018-10-18 | 2019-08-13 | 두경부암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 두경부암 약물 반응성 판단 방법 및 두경부암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
| KR1020190098498A KR20200044678A (ko) | 2018-10-18 | 2019-08-13 | 여성암 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 여성암 약물 반응성 판단 방법 및 여성암 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
| KR1020190098577A KR20200044681A (ko) | 2018-10-18 | 2019-08-13 | Erk_mapk 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 erk_mapk 약물 반응성 판단 방법 및 erk_mapk 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
| KR1020190098597A KR20200044683A (ko) | 2018-10-18 | 2019-08-13 | Mitosis 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 mitosis 약물 반응성 판단 방법 및 mitosis 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
| KR1020190098585A KR20200044682A (ko) | 2018-10-18 | 2019-08-13 | Igfr 약물 반응성 판단을 위한 바이오 마커 조성물, 바이오 마커 조성물을 이용한 igfr 약물 반응성 판단 방법 및 igfr 약물 반응성 판단을 위한 바이오 마커 조성물 검출용 진단칩 |
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| KR102222520B1 (ko) * | 2020-09-04 | 2021-03-05 | 연세대학교 산학협력단 | 약물 반응성 예측용 조성물 및 이의 용도 |
| KR102222521B1 (ko) * | 2020-09-04 | 2021-03-05 | 연세대학교 산학협력단 | 약물 반응성을 예측하는 방법 |
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2019
- 2019-08-13 KR KR1020190098551A patent/KR20200044680A/ko not_active Application Discontinuation
- 2019-08-13 KR KR1020190098517A patent/KR20200043891A/ko not_active Application Discontinuation
- 2019-08-13 KR KR1020190098498A patent/KR20200044678A/ko not_active Application Discontinuation
- 2019-08-13 KR KR1020190098577A patent/KR20200044681A/ko not_active Application Discontinuation
- 2019-08-13 KR KR1020190098597A patent/KR20200044683A/ko not_active Application Discontinuation
- 2019-08-13 KR KR1020190098585A patent/KR20200044682A/ko not_active Application Discontinuation
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| (001) Forbes, S. A., et al. COSMIC: somatic cancer genetics at high-resolution. Nucleic Acids Research. 45, 777-783 (2017). |
| (002) Williams SP, & McDermott U. The pursuit of therapeutic biomarkers with high-throughput cancer cell drug screens. Cell Chemical Biology. 24, 1066-1074 (2017). |
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20200043891A (ko) | 2020-04-28 |
| KR20200044683A (ko) | 2020-04-29 |
| KR20200044681A (ko) | 2020-04-29 |
| KR20200044678A (ko) | 2020-04-29 |
| KR20200044682A (ko) | 2020-04-29 |
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