WO2010058902A3 - 열감응성 조직 유착 방지 조성물 및 이의 제조 방법 - Google Patents

열감응성 조직 유착 방지 조성물 및 이의 제조 방법 Download PDF

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Publication number
WO2010058902A3
WO2010058902A3 PCT/KR2009/005280 KR2009005280W WO2010058902A3 WO 2010058902 A3 WO2010058902 A3 WO 2010058902A3 KR 2009005280 W KR2009005280 W KR 2009005280W WO 2010058902 A3 WO2010058902 A3 WO 2010058902A3
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WO
WIPO (PCT)
Prior art keywords
composition
tissue adhesion
linking
cross
preventing tissue
Prior art date
Application number
PCT/KR2009/005280
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English (en)
French (fr)
Other versions
WO2010058902A2 (ko
Inventor
최진석
이영우
이윤기
김준호
이진호
Original Assignee
주식회사 바이오레인
한남대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 바이오레인, 한남대학교 산학협력단 filed Critical 주식회사 바이오레인
Priority to DK09827667.8T priority Critical patent/DK2366409T3/en
Priority to CN200980149694.2A priority patent/CN102245212B/zh
Priority to EP09827667.8A priority patent/EP2366409B1/en
Priority to US13/129,765 priority patent/US9095643B2/en
Priority to PL09827667T priority patent/PL2366409T3/pl
Priority to JP2011537345A priority patent/JP5604440B2/ja
Priority to ES09827667.8T priority patent/ES2526453T3/es
Publication of WO2010058902A2 publication Critical patent/WO2010058902A2/ko
Publication of WO2010058902A3 publication Critical patent/WO2010058902A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Polymers & Plastics (AREA)

Abstract

본 발명은 열감응성 조직 유착 방지 조성물 및 그 제조방법에 관한 것으로서, 보다 상세하게는 조직유착 억제성능을 지니는 폴리에틸렌옥사이드 블록을 함유하는 블록 공중합체 및 상기 공중합체와 혼합될 수 있는 분자량 10,000 내지 1,000,000 g/mol인 고분자를 포함하는 수용액에 가교제를 가하여 화학반응이 일어나도록 하여 제조되며, 선택적으로 염증반응을 억제시킬 수 있는 약물을 더 포함하는 조성물로서, 상기 조성물을 원심분리하였을 때 상층액과 하층액의 점도, 가시광선 영역의 흡광도 및 안정성의 차이가 10% 이내인 것을 특징으로 하는 열감응성 조직 유착 방지 조성물에 관한 것이며, 또한 상기 조성물을 제조함에 있어서 반응속도 지연제를 첨가하지 않고 스프레이 방법 및 교반 방법을 동시에 사용하여 가교의 균일화 및 점도의 안정성이 우수하게 되는 것을 특징으로 하는 열감응성 조직유착 방지 조성물의 제조방법에 관한 것이다. 본 발명에 따르면, 가교가 고르게 되지 않아 생기는 섬유상의 부유물을 방지할 수 있을 뿐만 아니라, 가교의 균일화와 점도의 안정화를 높일 수 있어 인체 내 상처부위에 매우 고르게 도포 가능하며 안정성 및 조직 유착 방지 효과가 우수한 열감응성 조직 유착 방지용 조성물을 제공하는 효과가 있다.
PCT/KR2009/005280 2008-11-19 2009-09-17 열감응성 조직 유착 방지 조성물 및 이의 제조 방법 WO2010058902A2 (ko)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DK09827667.8T DK2366409T3 (en) 2008-11-19 2009-09-17 Thermosensitive composition as PREVENTING tissue adhesion AND MANUFACTURING METHOD THEREOF
CN200980149694.2A CN102245212B (zh) 2008-11-19 2009-09-17 防止组织粘连的热敏组合物及其制造方法
EP09827667.8A EP2366409B1 (en) 2008-11-19 2009-09-17 Thermosensitive composition preventing tissue adhesion and preparation method thereof
US13/129,765 US9095643B2 (en) 2008-11-19 2009-09-17 Composition preventing tissue adhesion and preparation method thereof
PL09827667T PL2366409T3 (pl) 2008-11-19 2009-09-17 Termowrażliwa kompozycja zapobiegająca zrastaniu się tkanek i sposób jej wytwarzania
JP2011537345A JP5604440B2 (ja) 2008-11-19 2009-09-17 熱感応性組織癒着防止用組成物およびその製造方法
ES09827667.8T ES2526453T3 (es) 2008-11-19 2009-09-17 Composición termosensible que previene la adhesión de los tejidos y método para su preparación

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080114946A KR101125934B1 (ko) 2008-11-19 2008-11-19 열감응성 조직 유착 방지 조성물 및 이의 제조 방법
KR10-2008-0114946 2008-11-19

Publications (2)

Publication Number Publication Date
WO2010058902A2 WO2010058902A2 (ko) 2010-05-27
WO2010058902A3 true WO2010058902A3 (ko) 2010-07-15

Family

ID=42198618

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/005280 WO2010058902A2 (ko) 2008-11-19 2009-09-17 열감응성 조직 유착 방지 조성물 및 이의 제조 방법

Country Status (10)

Country Link
US (1) US9095643B2 (ko)
EP (1) EP2366409B1 (ko)
JP (1) JP5604440B2 (ko)
KR (1) KR101125934B1 (ko)
CN (1) CN102245212B (ko)
DK (1) DK2366409T3 (ko)
ES (1) ES2526453T3 (ko)
PL (1) PL2366409T3 (ko)
PT (1) PT2366409E (ko)
WO (1) WO2010058902A2 (ko)

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WO2013015579A2 (ko) * 2011-07-26 2013-01-31 (주)차바이오앤디오스텍 콜라겐 및 히알루론산 유도체를 포함하는 의료용 복합 생체 소재
KR101330652B1 (ko) * 2012-02-28 2013-11-18 (주)시지바이오 성장인자 담지 가능한 유착방지용 고분자 조성물
KR101389831B1 (ko) * 2012-05-25 2014-05-07 한남대학교 산학협력단 온도 감응형 유착방지제
US20150209481A1 (en) * 2012-08-16 2015-07-30 Nipro Corporation Antiadhesive Material
CN104027850A (zh) * 2014-06-03 2014-09-10 陈凯 一种术后冲洗剂及其制备方法
US10105387B2 (en) 2014-07-24 2018-10-23 Medytox Inc. Temperature sensitive adhesion prevention composition and use thereof
PL409231A1 (pl) * 2014-08-21 2016-02-29 Warszawski Uniwersytet Medyczny Sposób wytwarzania gwoździ śródszpikowych z chitozanu do leczenia złamań kości długich
KR101852718B1 (ko) * 2017-04-04 2018-05-18 주식회사 제네웰 외과수술 후 절개부위 통증 감소를 위한 키트
KR101923734B1 (ko) 2017-04-13 2018-11-29 영남대학교 산학협력단 유착 방지용 가교 필름
KR101981562B1 (ko) * 2017-05-04 2019-05-24 주식회사 테라시온 바이오메디칼 유착방지용 조성물의 제조방법
CN108159508B (zh) * 2018-01-03 2021-01-26 东南大学 一种防粘连医用水凝胶材料的制备方法
KR101902956B1 (ko) 2018-03-13 2018-10-02 주식회사 제네웰 외과수술 후 절개부위 통증 감소를 위한 키트
KR102065016B1 (ko) 2018-04-17 2020-01-10 주식회사 제네웰 외과수술 후 절개부위 통증 감소 또는 치료를 위한 키트
KR102144479B1 (ko) * 2018-05-24 2020-08-13 주식회사 덱스레보 조직 수복용 조성물 및 이의 제조방법
KR102251192B1 (ko) * 2020-08-07 2021-05-13 주식회사 덱스레보 조직 수복용 조성물 및 이의 제조방법

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Also Published As

Publication number Publication date
CN102245212A (zh) 2011-11-16
WO2010058902A2 (ko) 2010-05-27
PL2366409T3 (pl) 2015-03-31
KR20100056009A (ko) 2010-05-27
EP2366409B1 (en) 2014-12-10
JP5604440B2 (ja) 2014-10-08
US9095643B2 (en) 2015-08-04
KR101125934B1 (ko) 2012-03-21
US20110229432A1 (en) 2011-09-22
DK2366409T3 (en) 2015-01-12
ES2526453T3 (es) 2015-01-12
JP2012509129A (ja) 2012-04-19
CN102245212B (zh) 2014-06-18
PT2366409E (pt) 2015-01-13
EP2366409A4 (en) 2013-07-31
EP2366409A2 (en) 2011-09-21

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