WO2009044426A1 - 分取精製装置 - Google Patents

分取精製装置 Download PDF

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Publication number
WO2009044426A1
WO2009044426A1 PCT/JP2007/001070 JP2007001070W WO2009044426A1 WO 2009044426 A1 WO2009044426 A1 WO 2009044426A1 JP 2007001070 W JP2007001070 W JP 2007001070W WO 2009044426 A1 WO2009044426 A1 WO 2009044426A1
Authority
WO
WIPO (PCT)
Prior art keywords
water
target compound
dichloromethane
eluate
trap column
Prior art date
Application number
PCT/JP2007/001070
Other languages
English (en)
French (fr)
Inventor
Yutaka Kono
Masayuki Nishimura
Bob Boughtflower
Przemyslaw Stasica
Original Assignee
Shimadzu Corporation
Glaxosmithkline
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corporation, Glaxosmithkline filed Critical Shimadzu Corporation
Priority to GB1006547.2A priority Critical patent/GB2465954B/en
Priority to JP2009535886A priority patent/JP4840511B2/ja
Priority to PCT/JP2007/001070 priority patent/WO2009044426A1/ja
Priority to US12/681,276 priority patent/US8607620B2/en
Publication of WO2009044426A1 publication Critical patent/WO2009044426A1/ja

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/203—Equilibration or regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/24—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/08—Preparation using an enricher
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

　カラムラック（８）により略垂直起立状に保持されたトラップカラム（７）内の吸着剤に目的化合物が捕集され、洗浄のために内部が水で置換された後に、水よりも比重が大きく、水と相溶性がないジクロロメタンを送液ポンプ（５）により下端の入口端（７ａ）からゆっくりと導入する。トラップカラム（７）内の水はジクロロメタンにより押し上げられ、出口端（７ｂ）から流出し、二方切替バルブ（１２）、廃液流路（１４）を経て廃棄される。ジクロロメタンは捕集されている目的化合物を溶出させるため、トラップカラム（７）からの溶出液が水、エマルジョンを経てジクロロメタンに変化すると、十分な濃度の目的化合物が溶出液に含まれているから、二方切替バルブ（１２）を分取流路（１３）に切り替える。これにより、水を十分に除去し、目的化合物が含まれる溶出液を回収容器（１７）に回収し、迅速に固形状の目的化合物を得ることができる。
PCT/JP2007/001070 2007-10-02 2007-10-02 分取精製装置 WO2009044426A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB1006547.2A GB2465954B (en) 2007-10-02 2007-10-02 Preparative separation/ purification system
JP2009535886A JP4840511B2 (ja) 2007-10-02 2007-10-02 分取精製装置
PCT/JP2007/001070 WO2009044426A1 (ja) 2007-10-02 2007-10-02 分取精製装置
US12/681,276 US8607620B2 (en) 2007-10-02 2007-10-02 Preparative separation/purification system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/001070 WO2009044426A1 (ja) 2007-10-02 2007-10-02 分取精製装置

Publications (1)

Publication Number Publication Date
WO2009044426A1 true WO2009044426A1 (ja) 2009-04-09

Family

ID=40525860

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/001070 WO2009044426A1 (ja) 2007-10-02 2007-10-02 分取精製装置

Country Status (4)

Country Link
US (1) US8607620B2 (ja)
JP (1) JP4840511B2 (ja)
GB (1) GB2465954B (ja)
WO (1) WO2009044426A1 (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011164049A (ja) * 2010-02-15 2011-08-25 Shimadzu Corp 分取精製装置
JP2015178967A (ja) * 2014-03-18 2015-10-08 株式会社島津製作所 ガス吹付式液体試料注入装置及びそれに用いられる注入容器
JP2016061691A (ja) * 2014-09-18 2016-04-25 株式会社島津製作所 試料回収容器の搭載加熱機構
US9630125B2 (en) 2015-06-08 2017-04-25 Shimadzu Corporation Gas-blowing liquid sample infusing device and infusion container used for the same
CN108139369A (zh) * 2015-10-02 2018-06-08 株式会社岛津制作所 分离纯化装置
WO2018167910A1 (ja) * 2017-03-16 2018-09-20 株式会社島津製作所 分取液体クロマトグラフ
US10124270B2 (en) 2011-07-26 2018-11-13 Shimadzu Corporation Gas blowing vaporizing and drying device
US10184918B2 (en) 2016-10-07 2019-01-22 Shimadzu Corporation Gas-spouting liquid-sample injector and injection container for the same
US10434436B2 (en) 2012-08-22 2019-10-08 Shimadzu Co. Gas-blowing vaporizing and drying device
US10722893B2 (en) 2017-01-13 2020-07-28 Shimadzu Corporation Mounting and heating mechanism of sample collection containers

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009044426A1 (ja) 2007-10-02 2009-04-09 Shimadzu Corporation 分取精製装置
WO2009044425A1 (ja) * 2007-10-02 2009-04-09 Shimadzu Corporation 分取精製装置
US20090158820A1 (en) * 2007-12-20 2009-06-25 Schlumberger Technology Corporation Method and system for downhole analysis
JP5880269B2 (ja) * 2012-05-15 2016-03-08 株式会社島津製作所 分取精製装置
JP5799889B2 (ja) * 2012-05-15 2015-10-28 株式会社島津製作所 分取精製装置
JP5821773B2 (ja) * 2012-05-15 2015-11-24 株式会社島津製作所 往復動型ポンプの制御装置及び制御方法
US9884266B2 (en) * 2013-07-08 2018-02-06 Orlab Chromatography, Llc Fluoropolymer pneumatically/hydraulically actuated liquid chromatographic system for use with harsh reagents
WO2016021715A1 (ja) * 2014-08-08 2016-02-11 株式会社島津製作所 分取液体クロマトグラフ装置及び分取条件探索方法
EP3343217A4 (en) * 2015-08-24 2018-09-26 Shimadzu Corporation Separation/purification apparatus
CN110251993B (zh) * 2019-07-19 2023-04-28 扬州罗素生物技术有限公司 一种基于大孔树脂吸附的中药多组分分离的集成装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02122260A (ja) * 1988-10-31 1990-05-09 Shimadzu Corp 分取用液体クロマトグラフ
JP2006349356A (ja) * 2005-06-13 2006-12-28 Showa Denko Kk 分離処理用の充填材の製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6219758A (ja) 1985-07-18 1987-01-28 Kagakuhin Kensa Kyokai 液体クロマトグラフイ−用試料濃縮装置
JPH07318545A (ja) * 1994-05-30 1995-12-08 Hitachi Ltd 自動前処理機能付ガスクロマトグラフ
JPH1194812A (ja) * 1997-09-22 1999-04-09 Asahi Breweries Ltd 飲料中のジオール類の検出法
JP2002257807A (ja) * 2000-12-15 2002-09-11 Mitsubishi Heavy Ind Ltd 有機ハロゲン化物の検出装置及び方法
JP3719407B2 (ja) 2001-11-13 2005-11-24 株式会社島津製作所 分取液体クロマトグラフ
JP4194081B2 (ja) * 2003-03-05 2008-12-10 株式会社サタケ ポリ塩化ジベンゾ−ｐ−ダイオキシン又は／及びポリ塩化ジベンゾフランの微量分析法
ITMI20032399A1 (it) * 2003-12-09 2005-06-10 Zambon Spa Composizione farmaceutica contenente gabapentina.
JP2005172758A (ja) * 2003-12-15 2005-06-30 Miura Co Ltd ダイオキシン類の分析用試料調製方法および調製装置
CN101253406A (zh) * 2005-08-30 2008-08-27 财团法人杂贺技术研究所 有机化学物质的分析前处理装置及其分析前处理方法
WO2009044426A1 (ja) 2007-10-02 2009-04-09 Shimadzu Corporation 分取精製装置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02122260A (ja) * 1988-10-31 1990-05-09 Shimadzu Corp 分取用液体クロマトグラフ
JP2006349356A (ja) * 2005-06-13 2006-12-28 Showa Denko Kk 分離処理用の充填材の製造方法

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2365328A1 (en) * 2010-02-15 2011-09-14 Shimadzu Corporation Preparative separation/purification system
US8932460B2 (en) 2010-02-15 2015-01-13 Shimadzu Corporation Preparative separation/purification system
JP2011164049A (ja) * 2010-02-15 2011-08-25 Shimadzu Corp 分取精製装置
US10124270B2 (en) 2011-07-26 2018-11-13 Shimadzu Corporation Gas blowing vaporizing and drying device
US10434436B2 (en) 2012-08-22 2019-10-08 Shimadzu Co. Gas-blowing vaporizing and drying device
JP2015178967A (ja) * 2014-03-18 2015-10-08 株式会社島津製作所 ガス吹付式液体試料注入装置及びそれに用いられる注入容器
JP2016061691A (ja) * 2014-09-18 2016-04-25 株式会社島津製作所 試料回収容器の搭載加熱機構
US9630125B2 (en) 2015-06-08 2017-04-25 Shimadzu Corporation Gas-blowing liquid sample infusing device and infusion container used for the same
CN108139369A (zh) * 2015-10-02 2018-06-08 株式会社岛津制作所 分离纯化装置
US20180238841A1 (en) * 2015-10-02 2018-08-23 Shimadzu Corporation Preparative separation and purification device and preparative separation and purification method
US10184918B2 (en) 2016-10-07 2019-01-22 Shimadzu Corporation Gas-spouting liquid-sample injector and injection container for the same
US10722893B2 (en) 2017-01-13 2020-07-28 Shimadzu Corporation Mounting and heating mechanism of sample collection containers
WO2018167910A1 (ja) * 2017-03-16 2018-09-20 株式会社島津製作所 分取液体クロマトグラフ
US11774413B2 (en) 2017-03-16 2023-10-03 Shimadzu Corporation Preparative liquid chromatograph

Also Published As

Publication number Publication date
GB2465954A (en) 2010-06-09
GB2465954B (en) 2012-04-04
US8607620B2 (en) 2013-12-17
US20100281958A1 (en) 2010-11-11
JPWO2009044426A1 (ja) 2011-01-27
GB201006547D0 (en) 2010-06-02
JP4840511B2 (ja) 2011-12-21

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