WO2009041062A1 - 血漿中動態が改善されたグリピカン３抗体 - Google Patents

血漿中動態が改善されたグリピカン３抗体 Download PDF

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Publication number
WO2009041062A1
WO2009041062A1 PCT/JP2008/002690 JP2008002690W WO2009041062A1 WO 2009041062 A1 WO2009041062 A1 WO 2009041062A1 JP 2008002690 W JP2008002690 W JP 2008002690W WO 2009041062 A1 WO2009041062 A1 WO 2009041062A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
glypican
plasma
life
pharmaceutical composition
Prior art date
Application number
PCT/JP2008/002690
Other languages
English (en)
French (fr)
Inventor
Tomoyuki Igawa
Taichi Kuramochi
Hirotake Shiraiwa
Hiroyuki Tsunoda
Tatsuhiko Tachibana
Takahiro Ishiguro
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40510966&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009041062(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP08834671A priority Critical patent/EP2196541B1/en
Priority to KR1020157030933A priority patent/KR20150126724A/ko
Priority to CA2700986A priority patent/CA2700986A1/en
Priority to BRPI0817637A priority patent/BRPI0817637A2/pt
Priority to DK08834671.3T priority patent/DK2196541T3/da
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to MX2010003158A priority patent/MX2010003158A/es
Priority to NZ584769A priority patent/NZ584769A/en
Priority to ES08834671T priority patent/ES2394471T3/es
Priority to CN2008801091960A priority patent/CN101809162B/zh
Priority to JP2009534190A priority patent/JP4535406B2/ja
Priority to AU2008305851A priority patent/AU2008305851B2/en
Priority to US12/733,933 priority patent/US8497355B2/en
Priority to CL2009000647A priority patent/CL2009000647A1/es
Priority to BRPI0911147A priority patent/BRPI0911147A2/pt
Priority to JP2010505322A priority patent/JP5306327B2/ja
Priority to SG2013025549A priority patent/SG189754A1/en
Priority to EP09727052A priority patent/EP2275135A4/en
Priority to MX2010010954A priority patent/MX2010010954A/es
Priority to CA2720359A priority patent/CA2720359A1/en
Priority to PE2009000413A priority patent/PE20091655A1/es
Priority to PCT/JP2009/001249 priority patent/WO2009122667A1/ja
Priority to TW98108942A priority patent/TWI468175B/zh
Priority to UAA201013035A priority patent/UA103614C2/uk
Priority to KR1020107024691A priority patent/KR101612139B1/ko
Priority to CN200980119069.3A priority patent/CN102046200B/zh
Priority to ARP090100996A priority patent/AR071003A1/es
Priority to NZ588913A priority patent/NZ588913A/xx
Priority to RU2010145177/15A priority patent/RU2523897C2/ru
Priority to AU2009233301A priority patent/AU2009233301B2/en
Publication of WO2009041062A1 publication Critical patent/WO2009041062A1/ja
Priority to IL204754A priority patent/IL204754A0/en
Priority to MA32777A priority patent/MA31780B1/fr
Priority to ZA2010/02741A priority patent/ZA201002741B/en
Priority to IL208451A priority patent/IL208451A0/en
Priority to CO10133385A priority patent/CO6300964A2/es
Priority to CR11769A priority patent/CR11769A/es
Priority to MA33323A priority patent/MA32360B1/fr
Priority to EC2010010589A priority patent/ECSP10010589A/es
Priority to HK10111189.6A priority patent/HK1144702A1/xx
Priority to JP2010291590A priority patent/JP5506654B2/ja
Priority to HK11105940.7A priority patent/HK1151734A1/xx
Priority to US13/924,957 priority patent/US20130295612A1/en
Priority to US14/629,967 priority patent/US20150315278A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

【課題】　グリピカン３抗体の血漿中半減期を制御する方法、血漿中半減期が制御されたグリピカン３抗体を有効成分として含有する医薬組成物、並びに、当該グリピカン３抗体および当該グリピカン３抗体を有効成分として含む医薬組成物の製造方法を提供すること。 【解決手段】 　グリピカン３抗体の表面に露出するアミノ酸残基の改変により、グリピカン３抗体の血漿中半減期を制御する方法、アミノ酸残基の改変により血漿中半減期が制御されたグリピカン３抗体、当該抗体を有効成分として含む医薬組成物、並びに、それらの医薬組成物の製造方法が開示される。
PCT/JP2008/002690 2007-09-28 2008-09-26 血漿中動態が改善されたグリピカン３抗体 WO2009041062A1 (ja)

Priority Applications (42)

Application Number Priority Date Filing Date Title
US12/733,933 US8497355B2 (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
NZ584769A NZ584769A (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
CA2700986A CA2700986A1 (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
BRPI0817637A BRPI0817637A2 (pt) 2007-09-28 2008-09-26 anticorpo anti-glipican-3 tendo cinéticas aperfeiçoadas no plasma
DK08834671.3T DK2196541T3 (da) 2007-09-28 2008-09-26 Anti-glypican-3-antistof med forbedret kinetik i plasmaet
EP08834671A EP2196541B1 (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
MX2010003158A MX2010003158A (es) 2007-09-28 2008-09-26 Anticuerpo anti-glipicano-3 que tiene cinetica mejorada en plasma.
KR1020157030933A KR20150126724A (ko) 2007-09-28 2008-09-26 혈장 중 반응속도가 개선된 항-글리피칸-3 항체
ES08834671T ES2394471T3 (es) 2007-09-28 2008-09-26 Anticuerpo Anti-Glipicano 3 que tiene una cinética mejorada en plasma
CN2008801091960A CN101809162B (zh) 2007-09-28 2008-09-26 血浆中动力学被改善的磷脂酰肌醇蛋白聚糖3抗体
JP2009534190A JP4535406B2 (ja) 2007-09-28 2008-09-26 血漿中動態が改善されたグリピカン３抗体
AU2008305851A AU2008305851B2 (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
CL2009000647A CL2009000647A1 (es) 2008-04-04 2009-03-18 Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.
UAA201013035A UA103614C2 (uk) 2008-04-04 2009-03-19 Лікарський засіб, що містить комбінацію інгібітора кінази та анти-гліпікан 3-антитіла, для лікування раку печінки
PCT/JP2009/001249 WO2009122667A1 (ja) 2008-04-04 2009-03-19 肝癌治療剤
AU2009233301A AU2009233301B2 (en) 2008-04-04 2009-03-19 Liver cancer drug
SG2013025549A SG189754A1 (en) 2008-04-04 2009-03-19 Liver cancer drug
EP09727052A EP2275135A4 (en) 2008-04-04 2009-03-19 THERAPY FOR HEPATIC CANCER
MX2010010954A MX2010010954A (es) 2008-04-04 2009-03-19 Farmaco contra cancer de higado.
CA2720359A CA2720359A1 (en) 2008-04-04 2009-03-19 Liver cancer drug
PE2009000413A PE20091655A1 (es) 2008-04-04 2009-03-19 Farmaco para el cancer de higado
BRPI0911147A BRPI0911147A2 (pt) 2008-04-04 2009-03-19 fármaco contra câncer de fígado
TW98108942A TWI468175B (zh) 2008-04-04 2009-03-19 Liver cancer treatment
JP2010505322A JP5306327B2 (ja) 2008-04-04 2009-03-19 肝癌治療剤
KR1020107024691A KR101612139B1 (ko) 2008-04-04 2009-03-19 간암 치료제
CN200980119069.3A CN102046200B (zh) 2008-04-04 2009-03-19 肝癌治疗剂
ARP090100996A AR071003A1 (es) 2008-04-04 2009-03-19 Farmaco contra cancer de higado
NZ588913A NZ588913A (en) 2008-04-04 2009-03-19 Liver cancer drug
RU2010145177/15A RU2523897C2 (ru) 2008-04-04 2009-03-19 Лекарственное средство для лечения рака печени
IL204754A IL204754A0 (en) 2007-09-28 2010-03-25 Anti-glypican - 3 - antibody having improved kinetics in plasma
MA32777A MA31780B1 (fr) 2007-09-28 2010-04-14 Anticorps anti-glypican-3 dont la cinétique dans le plasma est améliorée
ZA2010/02741A ZA201002741B (en) 2007-09-28 2010-04-19 Anti-glypican-3 antibody having improved kinetics in plasma
IL208451A IL208451A0 (en) 2008-04-04 2010-10-03 Pharmaceutical compositions comprising a chemotherapeutic agent and an anti-glypican 3 antibody for use in treating hepatic cancer
CO10133385A CO6300964A2 (es) 2008-04-04 2010-10-27 Una composicion farmaceutica que comprende una combinacion de un agente quimioterapeutico y un anticuerpo 3 antiglipicano
CR11769A CR11769A (es) 2008-04-04 2010-11-01 Farmaco contra el cancer de higado
MA33323A MA32360B1 (fr) 2008-04-04 2010-11-03 Thérapie pour cancer hépatique
EC2010010589A ECSP10010589A (es) 2008-04-04 2010-11-04 Farmaco contra el cancer de higado
HK10111189.6A HK1144702A1 (en) 2007-09-28 2010-12-01 Anti-glypican-3 antibody having improved kinetics in plasma
JP2010291590A JP5506654B2 (ja) 2008-04-04 2010-12-28 肝癌治療剤
HK11105940.7A HK1151734A1 (en) 2008-04-04 2011-06-13 Therapeutic for hepatic cancer
US13/924,957 US20130295612A1 (en) 2007-09-28 2013-07-25 Anti-glypican-3 antibody having improved kinetics in plasma
US14/629,967 US20150315278A1 (en) 2007-09-28 2015-02-24 Anti-Glypican-3 Antibody Having Improved Kinetics in Plasma

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007256063 2007-09-28
JP2007-256063 2007-09-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/733,933 A-371-Of-International US8497355B2 (en) 2007-09-28 2008-09-26 Anti-glypican-3 antibody having improved kinetics in plasma
US13/924,957 Division US20130295612A1 (en) 2007-09-28 2013-07-25 Anti-glypican-3 antibody having improved kinetics in plasma

Publications (1)

Publication Number Publication Date
WO2009041062A1 true WO2009041062A1 (ja) 2009-04-02

Family

ID=40510966

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002690 WO2009041062A1 (ja) 2007-09-28 2008-09-26 血漿中動態が改善されたグリピカン３抗体

Country Status (26)

Country Link
US (3) US8497355B2 (ja)
EP (3) EP2617736A1 (ja)
JP (3) JP4535406B2 (ja)
KR (2) KR20100085067A (ja)
CN (1) CN101809162B (ja)
AR (1) AR066172A1 (ja)
AU (1) AU2008305851B2 (ja)
BR (1) BRPI0817637A2 (ja)
CA (1) CA2700986A1 (ja)
CL (1) CL2008002873A1 (ja)
CO (1) CO6270266A2 (ja)
CR (1) CR11369A (ja)
DK (1) DK2196541T3 (ja)
EC (1) ECSP10010135A (ja)
ES (1) ES2394471T3 (ja)
HK (1) HK1144702A1 (ja)
IL (1) IL204754A0 (ja)
MA (1) MA31780B1 (ja)
MX (1) MX2010003158A (ja)
MY (1) MY148637A (ja)
NZ (1) NZ584769A (ja)
PE (1) PE20091218A1 (ja)
RU (2) RU2445366C2 (ja)
TW (1) TWI418363B (ja)
WO (1) WO2009041062A1 (ja)
ZA (1) ZA201002741B (ja)

Cited By (55)

* Cited by examiner, † Cited by third party
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WO2009077569A1 (en) * 2007-12-19 2009-06-25 General Electric Company Biokinetics of fast-clearing polypeptides
US20110104157A1 (en) * 2008-04-04 2011-05-05 Chugai Seiyaku Kabushiki Kaisha Liver cancer drug
US8124725B2 (en) 2007-12-19 2012-02-28 General Electric Company PDGF-Rβ binders
WO2012115241A1 (ja) 2011-02-25 2012-08-30 中外製薬株式会社 FcγRIIb特異的Fc抗体
WO2012133782A1 (ja) 2011-03-30 2012-10-04 中外製薬株式会社 抗原結合分子の血漿中滞留性と免疫原性を改変する方法
WO2013002362A1 (ja) 2011-06-30 2013-01-03 中外製薬株式会社 ヘテロ二量化ポリペプチド
JPWO2011108714A1 (ja) * 2010-03-04 2013-06-27 中外製薬株式会社 抗体定常領域改変体
WO2013100120A1 (ja) 2011-12-28 2013-07-04 中外製薬株式会社 ヒト化抗Epiregulin抗体および当該抗体を有効成分として含む癌治療剤
JP2013539361A (ja) * 2010-07-29 2013-10-24 ゼンコア インコーポレイテッド 改変された等電点を有する抗体
WO2013187495A1 (ja) 2012-06-14 2013-12-19 中外製薬株式会社 改変されたFc領域を含む抗原結合分子
KR20140015501A (ko) * 2011-03-30 2014-02-06 추가이 세이야쿠 가부시키가이샤 항원 결합 분자의 혈장 체류성과 면역원성을 개변하는 방법
WO2014030728A1 (ja) 2012-08-24 2014-02-27 中外製薬株式会社 FcγRIIb特異的Fc領域改変体
JPWO2012073992A1 (ja) * 2010-11-30 2014-05-19 中外製薬株式会社 複数分子の抗原に繰り返し結合する抗原結合分子
WO2014097648A1 (ja) 2012-12-21 2014-06-26 中外製薬株式会社 Gpc3標的治療剤療法が有効である患者に投与されるgpc3標的治療剤
WO2014104165A1 (ja) 2012-12-27 2014-07-03 中外製薬株式会社 ヘテロ二量化ポリペプチド
WO2014208482A1 (ja) 2013-06-24 2014-12-31 中外製薬株式会社 ヒト化抗Ｅｐｉｒｅｇｕｌｉｎ抗体を有効成分として含む腺癌以外の非小細胞肺癌の治療剤
US9228017B2 (en) 2009-03-19 2016-01-05 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
KR20170003972A (ko) 2014-05-08 2017-01-10 추가이 세이야쿠 가부시키가이샤 Gpc3 표적 치료제 요법이 유효한 환자에게 투여되는 gpc3 표적 치료제
US9670269B2 (en) 2006-03-31 2017-06-06 Chugai Seiyaku Kabushiki Kaisha Methods of modifying antibodies for purification of bispecific antibodies
US9688762B2 (en) 2007-09-26 2017-06-27 Chugai Sciyaku Kabushiki Kaisha Modified antibody constant region
US9765135B2 (en) 2014-12-19 2017-09-19 Chugai Seiyaku Kabushiki Kaisha Anti-C5 antibodies
WO2017159699A1 (en) 2016-03-15 2017-09-21 Chugai Seiyaku Kabushiki Kaisha Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies
US9828429B2 (en) 2007-09-26 2017-11-28 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in CDR
US9868948B2 (en) 2008-04-11 2018-01-16 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
EP2467400B1 (en) 2009-08-21 2018-01-24 Lonza Biologics plc. Variant immunoglobulins with improved manufacturability
WO2018038046A1 (ja) 2016-08-22 2018-03-01 中外製薬株式会社 ヒトｇｐｃ３ポリペプチドを発現する遺伝子改変非ヒト動物
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US10011858B2 (en) 2005-03-31 2018-07-03 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
WO2018155611A1 (ja) 2017-02-24 2018-08-30 中外製薬株式会社 薬学的組成物、抗原結合分子、治療方法、およびスクリーニング方法
US10118959B2 (en) 2005-10-14 2018-11-06 Chugai Seiyaku Kabushiki Kaisha Anti-glypican-3 antibody
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US11608374B2 (en) 2017-01-30 2023-03-21 Chugai Seiyaku Kabushiki Kaisha Anti-sclerostin antibodies and methods of use
US11649262B2 (en) 2015-12-28 2023-05-16 Chugai Seiyaku Kabushiki Kaisha Method for promoting efficiency of purification of Fc region-containing polypeptide
WO2023091909A1 (en) 2021-11-16 2023-05-25 Sotio Biotech Inc. Treatment of myxoid/round cell liposarcoma patients
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US11827699B2 (en) 2011-09-30 2023-11-28 Chugai Seiyaku Kabushiki Kaisha Methods for producing antibodies promoting disappearance of antigens having plurality of biological activities
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils
WO2024038144A1 (en) 2022-08-18 2024-02-22 Tribune Therapeutics Ab Agents that inhibit ccn ligand-induced signalling for treating disease

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US20230203177A1 (en) * 2020-05-18 2023-06-29 Bristol-Myers Squibb Company Antibody Variants with Improved Pharmacokinetic Properties
JPWO2022025030A1 (ja) 2020-07-28 2022-02-03
WO2023030539A1 (en) * 2021-09-06 2023-03-09 Nanjing Legend Biotech Co., Ltd. Anti-gpc3 chimeric antigen receptor and methods of use thereof
WO2024011186A2 (en) * 2022-07-08 2024-01-11 Imaginab, Inc. Antibodies and methods of making and using same

Citations (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125023A1 (en) 1983-04-08 1984-11-14 Genentech, Inc. Recombinant immunoglobulin preparations, methods for their preparation, DNA sequences, expression vectors and recombinant host cells therefor
EP0239400A2 (en) 1986-03-27 1987-09-30 Medical Research Council Recombinant antibodies and methods for their production
JPS6459878A (en) 1987-08-31 1989-03-07 Matsushita Electric Ind Co Ltd Semiconductor laser protective circuit
JPH0228200A (ja) * 1988-02-17 1990-01-30 Neorx Corp 電荷調整によるタンパク質の薬物動力学の変更
WO1992001047A1 (en) 1990-07-10 1992-01-23 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1992003918A1 (en) 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1992020791A1 (en) 1990-07-10 1992-11-26 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1993019172A1 (en) 1992-03-24 1993-09-30 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1994002602A1 (en) 1992-07-24 1994-02-03 Cell Genesys, Inc. Generation of xenogeneic antibodies
WO1995001438A1 (en) 1993-06-30 1995-01-12 Medical Research Council Sbp members with a chemical moiety covalently bound within the binding site; production and selection thereof
WO1995015388A1 (en) 1993-12-03 1995-06-08 Medical Research Council Recombinant binding proteins and peptides
WO1995015393A1 (fr) 1993-12-03 1995-06-08 Asahi Kasei Kogyo Kabushiki Kaisha Nouveau vecteur de detection d'expression
WO1996002576A1 (fr) 1994-07-13 1996-02-01 Chugai Seiyaku Kabushiki Kaisha Anticorps humain reconstitue contre l'interleukine-8 humaine
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1998013388A1 (fr) 1996-09-26 1998-04-02 Chugai Seiyaku Kabushiki Kaisha Anticorps contre les peptides lies a la parathormone humaine
WO1998046777A1 (fr) 1997-04-11 1998-10-22 Centre National De La Recherche Scientifique (Cnrs) Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
WO1999018212A1 (fr) 1997-10-03 1999-04-15 Chugai Seiyaku Kabushiki Kaisha Anticorps humain naturel
WO2003000883A1 (en) 2001-06-22 2003-01-03 Chugai Seiyaku Kabushiki Kaisha Cell proliferation inhibitors containing anti-glypican 3 antibody
WO2006046751A1 (ja) 2004-10-26 2006-05-04 Chugai Seiyaku Kabushiki Kaisha 糖鎖改変抗グリピカン３抗体
WO2006067913A1 (ja) 2004-12-22 2006-06-29 Chugai Seiyaku Kabushiki Kaisha フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法
WO2007005612A2 (en) * 2005-07-01 2007-01-11 Medimmune, Inc. An integrated approach for generating multidomain protein therapeutics
JP2007256063A (ja) 2006-03-23 2007-10-04 Seiko Epson Corp 表示装置、および、電子機器
JP2008504970A (ja) 2004-07-06 2008-02-21 エス・エム・エス・デマーク・アクチエンゲゼルシャフト 多段圧延スタンド、特に２０ロール送り圧延機構において冷間圧延の特殊鋼ストリップ或いは特殊鋼箔の平坦度及びストリップ応力又はそのいずれかの一方を測定制御する方法と装置

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127872A0 (en) * 1996-07-19 1999-10-28 Amgen Inc Analogs of cationic proteins
DK2270147T4 (da) * 1999-04-09 2020-08-31 Kyowa Kirin Co Ltd Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
US7317091B2 (en) * 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US20060088899A1 (en) * 2002-05-31 2006-04-27 Alvarez Vernon L Combination chemotherapy with chlorotoxin
AU2002330482A1 (en) * 2002-09-04 2004-03-29 Perseus Proteomics Inc. Method of diagnosing cancer by detecting gpc3
DK1553975T3 (da) * 2002-09-27 2012-05-07 Xencor Inc Optimerede Fc-varianter og fremgangsmåder til generering heraf.
US7217797B2 (en) * 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
PT1562972E (pt) 2002-10-15 2010-11-10 Facet Biotech Corp Alteração de afinidades de ligação ao fcrn ou semi-vidas séricas de anticorpos por mutagénese
CA2569277A1 (en) 2004-06-04 2005-12-15 Pfizer Products Inc. Method for treating abnormal cell growth
DE602005024502D1 (de) * 2004-07-09 2010-12-16 Chugai Pharmaceutical Co Ltd Anti-glypican-3-antikörper
CN102698267B (zh) 2004-08-24 2017-07-21 中外制药株式会社 使用抗磷脂酰肌醇蛋白聚糖‑3抗体的辅助疗法
JP4455236B2 (ja) * 2004-09-02 2010-04-21 本田技研工業株式会社 芝刈機
US20070087005A1 (en) * 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
WO2007053573A2 (en) 2005-10-31 2007-05-10 Bayer Pharmaceuticals Corporation Treatment of cancer with sorafenib
WO2007059111A2 (en) * 2005-11-14 2007-05-24 Entremed, Inc. Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
WO2007059782A1 (en) * 2005-11-28 2007-05-31 Genmab A/S Recombinant monovalent antibodies and methods for production thereof
KR20080101888A (ko) 2006-02-09 2008-11-21 다이이찌 산쿄 가부시키가이샤 항암 의약 조성물
WO2007099988A1 (ja) 2006-02-28 2007-09-07 Kyowa Hakko Kogyo Co., Ltd. α-1,6-フコシルトランスフェラーゼ変異体とその用途
CN104761637B (zh) * 2006-03-31 2021-10-15 中外制药株式会社 调控抗体血液动力学的方法
EP3345616A1 (en) * 2006-03-31 2018-07-11 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for purifying bispecific antibody
WO2007137170A2 (en) 2006-05-20 2007-11-29 Seattle Genetics, Inc. Anti-glypican-3 antibody drug conjugates
AU2008275985B2 (en) * 2007-07-17 2013-09-19 E. R. Squibb & Sons, L.L.C. Monoclonal antibodies against Glypican-3
EP3127921A1 (en) * 2007-09-26 2017-02-08 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substition in cdr
CL2009000647A1 (es) * 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.

Patent Citations (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125023A1 (en) 1983-04-08 1984-11-14 Genentech, Inc. Recombinant immunoglobulin preparations, methods for their preparation, DNA sequences, expression vectors and recombinant host cells therefor
EP0239400A2 (en) 1986-03-27 1987-09-30 Medical Research Council Recombinant antibodies and methods for their production
EP0239400B1 (en) 1986-03-27 1994-08-03 Medical Research Council Recombinant antibodies and methods for their production
JPS6459878A (en) 1987-08-31 1989-03-07 Matsushita Electric Ind Co Ltd Semiconductor laser protective circuit
JPH0228200A (ja) * 1988-02-17 1990-01-30 Neorx Corp 電荷調整によるタンパク質の薬物動力学の変更
WO1992020791A1 (en) 1990-07-10 1992-11-26 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1992001047A1 (en) 1990-07-10 1992-01-23 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1992003918A1 (en) 1990-08-29 1992-03-19 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1993019172A1 (en) 1992-03-24 1993-09-30 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1994002602A1 (en) 1992-07-24 1994-02-03 Cell Genesys, Inc. Generation of xenogeneic antibodies
WO1995001438A1 (en) 1993-06-30 1995-01-12 Medical Research Council Sbp members with a chemical moiety covalently bound within the binding site; production and selection thereof
WO1995015388A1 (en) 1993-12-03 1995-06-08 Medical Research Council Recombinant binding proteins and peptides
WO1995015393A1 (fr) 1993-12-03 1995-06-08 Asahi Kasei Kogyo Kabushiki Kaisha Nouveau vecteur de detection d'expression
WO1996002576A1 (fr) 1994-07-13 1996-02-01 Chugai Seiyaku Kabushiki Kaisha Anticorps humain reconstitue contre l'interleukine-8 humaine
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1998013388A1 (fr) 1996-09-26 1998-04-02 Chugai Seiyaku Kabushiki Kaisha Anticorps contre les peptides lies a la parathormone humaine
WO1998046777A1 (fr) 1997-04-11 1998-10-22 Centre National De La Recherche Scientifique (Cnrs) Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
WO1999018212A1 (fr) 1997-10-03 1999-04-15 Chugai Seiyaku Kabushiki Kaisha Anticorps humain naturel
WO2003000883A1 (en) 2001-06-22 2003-01-03 Chugai Seiyaku Kabushiki Kaisha Cell proliferation inhibitors containing anti-glypican 3 antibody
JP2008504970A (ja) 2004-07-06 2008-02-21 エス・エム・エス・デマーク・アクチエンゲゼルシャフト 多段圧延スタンド、特に２０ロール送り圧延機構において冷間圧延の特殊鋼ストリップ或いは特殊鋼箔の平坦度及びストリップ応力又はそのいずれかの一方を測定制御する方法と装置
WO2006046751A1 (ja) 2004-10-26 2006-05-04 Chugai Seiyaku Kabushiki Kaisha 糖鎖改変抗グリピカン３抗体
WO2006067913A1 (ja) 2004-12-22 2006-06-29 Chugai Seiyaku Kabushiki Kaisha フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法
WO2007005612A2 (en) * 2005-07-01 2007-01-11 Medimmune, Inc. An integrated approach for generating multidomain protein therapeutics
JP2007256063A (ja) 2006-03-23 2007-10-04 Seiko Epson Corp 表示装置、および、電子機器

Non-Patent Citations (68)

* Cited by examiner, † Cited by third party
Title
"A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
"Current Protocols in Immunology, Chapter 7, Immunologic studies in humans", 1993, JOHN WILEY & SONS, INC.
"Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS, pages: 9.1 - 9.9
"Current Protocols in Molecular Biology", 1987, PUBLISH. JOHN WILEY & SONS, pages: 11.4 - 11.11
"Strategies for Protein Purification and Characterization: A Laboratory Course Manual", 1996, COLD SPRING HARBOR LABORATORY PRESS
"These methods are described in a common textbook, Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
ABHINANDAN K. R.; MARTIN C. R., J. MOL. BIOL., vol. 369, 2007, pages 852 - 862
ADAMS C. W.; ALLISON D. E.; FLAGELLA K.; PRESTA L.; CLARKE J.; DYBDAL N.; MCKEEVER K.; SLIWKOWSKI M. X.: "Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab", CANCER IMMUNOL IMMUNOTHER, vol. 55, no. 6, 2006, pages 717 - 27
ALBINA NESTEROVA; PAUL J. CARTER; LEIA M. SMITH, GLYPICAN 3 AS A NOVEL TARGET FOR AN ANTIBODY-DRUG CONJUGATE, AACR ABSTRACT NO. 656, 4 April 2007 (2007-04-04)
AMIT ET AL., SCIENCE, vol. 233, 1986, pages 747 - 53
BIGGE J. C. ET AL., ANALYTICAL BIOCHEMISTRY, vol. 230, no. 2, 1995, pages 229 - 238
BINZ H. K.; AMSTUTZ P.; PLUCKTHUN A.: "Engineering novel binding proteins from nonimmunoglobulin domains", NAT. BIOTECHNOL., vol. 23, no. 10, 2005, pages 1257 - 68
BIOTECHNOL. BIOENG., vol. 87, no. 5, 2004, pages 614 - 22
BIOTECHNOL. BIOENG., vol. 93, no. 5, 2006, pages 851 - 61
CHOTHIA ET AL., J. MOL. BIOL., vol. 196, 1987, pages 901 - 17
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 8
COUTO J. R.; BLANK E. W.; PETERSON J. A.; CERIANI R. L.: "Anti-BA46 monoclonal antibody Mc3: humanization using a novel positional consensus and in vivo and in vitro characterization", CANCER RES., vol. 55, no. 8, 1995, pages 1717 - 22
COX K. M. ET AL., NAT. BIOTECHNOL., vol. 24, no. 12, 2006, pages 1591 - 7
DALL'ACQUA W. F.; DAMSCHRODER M. M.; ZHANG J.; WOODS R. M.; WIDJAJA L.; YU J.; WU H.: "Antibody humanization by framework shuffling", METHODS, vol. 36, no. 1, 2005, pages 43 - 60
EBERT ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
EWERT S.; HONEGGER A.; PLUCKTHUN A.: "Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure- based framework engineering", METHODS, vol. 34, no. 2, 2004, pages 184 - 99
G. KOHLER; C. MILSTEIN, METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
GHETIE V.; POPOV S.; BORVAK J.; RADU C.; MATESOI D.; MEDESAN C.; OBER R. J.; WARD E. S.: "Increasing the serum persistence of an IgG fragment by random mutagenesis", NAT. BIOTECHNOL., vol. 15, no. 7, 1997, pages 637 - 40
GHETIE V.; POPOV S.; BORVAK J.; RADU C.; MATESOI D.; MEDESAN C.; OBER R. J; WARD E. S.: "Increasing the serum persistence of an IgG fragment by random mutagenesis", NAT. BIOTECHNOL., vol. 15, no. 7, 1997, pages 637 - 40
GOBBURU J. V.; TENHOOR C.; ROGGE M. C.; FRAZIER D. E. JR.; THOMAS D.; BENJAMIN C.; HESS D. M.; JUSKO W. J.: "Pharmacokinetics/dynamics of 5c8, a monoclonal antibody to CD154 (CD40 ligand) suppression of an immune response in monkeys", J. PHARMACOL. EXP. THER., vol. 286, no. 2, 1998, pages 925 - 30
GODING: "Monoclonal Antibodies: Principles and Practice", 1986, ACADEMIC PRESS, pages: 59 - 103
GRAVES S. S.; GOSHORN S. C.; STONE D. M.; AXWORTHY D. B.; RENO J. M.; BOTTINO B.; SEARLE S.; HENRY A.; PEDERSEN J.; REES A. R.: "Molecular modeling and preclinical evaluation of the humanized NR-LU-13 antibody", CLIN. CANCER RES., vol. 5, no. 4, 1999, pages 899 - 908
GRIFFITHS ET AL., EMBO J., vol. 13, 1994, pages 3245 - 60
HE X. Y.; XU Z.; MELROSE J.; MULLOWNEY A.; VASQUEZ M.; QUEEN C.; VEXLER V.; KLINGBEIL C.; CO M. S.; BERG E. L.: "Humanization and pharmacokinetics of a monoclonal antibody with specificity for both E- and P-selectin", J. IMMUNOL., vol. 160, no. 2, 1998, pages 1029 - 35
HINTON P. R.; XIONG J. M.; JOHLFS M. G.; TANG M. T.; KELLER S.; TSURUSHITA N.: "An engineered human IgG1 antibody with longer serum half-life", J. IMMUNOL., vol. 176, no. 1, 2006, pages 346 - 56
J. EXP. MED., vol. 108, 1995, pages 945
JANICE M. REICHERT; CLARK J. ROSENSWEIG; LAURA B. FADEN; MATTHEW C. DEWITZ: "Monoclonal antibody successes in the clinic", NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 1073 - 8
JANICE M. REICHERT; VIIA E. VALGE-ARCHER: "Development trends for monoclonal antibody cancer therapeutics", NAT. REV. DRUG DISC., vol. 6, 2007, pages 349 - 356
K. SATO ET AL., CANCER RES., vol. 53, 1993, pages 851 - 856
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, NATIONAL INSTITUTE OF HEALTH
KASHMIRI S. V.; SHU L.; PADLAN E. A.; MILENIC D. E.; SCHLOM J.; HAND P. H.: "Generation, characterization, and in vivo studies of humanized anticarcinoma antibody CC49", HYBRIDOMA, vol. 14, no. 5, 1995, pages 461 - 73
KATAYOSE Y.; KUDO T.; SUZUKI M.; SHINODA M.; SAIJYO S.; SAKURAI N.; SAEKI H.; FUKUHARA K.; IMAI K.; MATSUNO S.: "MUCl-specific targeting immunotherapy with bispecific antibodies: inhibition of xenografted human bile duct carcinoma growth", CANCER RES., vol. 56, no. 18, 1996, pages 4205 - 12
KIM S. J.; PARK Y.; HONG H. J.: "Antibody engineering for the development of therapeutic antibodies", MOL. CELLS, vol. 20, no. 1, 2005, pages 17 - 29
KUNKEL, PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
LINKSOBER RJ; RADU CG; GHETIE V; WARD ES: "Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies", INT IMMUNOL., vol. 13, no. 12, 2001, pages 1551 - 9
LOBO E. D.; HANSEN R. J.; BALTHASAR J. P: "Antibody pharmacokinetics and pharmacodynamics", J. PHARM. SCI., vol. 93, no. 11, 2004, pages 2645 - 68
MA ET AL., EUR. J. IMMUNOL., vol. 24, 1994, pages 131 - 8
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581 - 97
MENDEZ ET AL., NAT. GENET., vol. 15, 1997, pages 146 - 56
MOL. CELL BIOL., vol. 8, 1988, pages 466 - 472
NATURE BIOTECHNOLOGY, vol. 24, 2006, pages 1591 - 7
NATURE BIOTECHNOLOGY, vol. 24, 2006, pages 210 - 5
ONO K.; OHTOMO T.; YOSHIDA K.; YOSHIMURA Y.; KAWAI S.; KOISHIHARA Y.; OZAKI S.; KOSAKA M.; TSUCHIYA M.: "The humanized anti-HM1.24 antibody effectively kills multiple myeloma cells by human effector cell-mediated cytotoxicity", MOL. IMMUNOL., vol. 36, no. 6, 1999, pages 387 - 395
PARDRIDGE W. M.; BUCIAK J.; YANG J.; WU D.: "Enhanced endocytosis in cultured human breast carcinoma cells and in vivo biodistribution in rats of a humanized monoclonal antibody after cationization of the protein", J PHARMACOL EXP THER., vol. 286, no. 1, 1998, pages 548 - 54
PAVLOU A. K.; BELSEY M. J.: "The therapeutic antibodies market to 2008", EUR. J. PHARM. BIOPHARM., vol. 59, no. 3, 2005, pages 389 - 96
PODUSLO J. F.; CURRAN G. L.: "Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers", NEUROCHEM, vol. 66, no. 4, 1996, pages 1599 - 609
POPO H., BIOCHEMICAL GENETICS, vol. 28, 1990, pages 299 - 308
RAJPAL A.; BEYAZ N.; HABER L.; CAPPUCCILLI G.; YEE H.; BHATT R. R.; TAKEUCHI T.; LERNER R. A.; CREA R.: "A general method for greatly improving the affinity of antibodies by using combinatorial libraries", PROC. NATL. ACAD. SCI. USA, vol. 102, no. 24, 2005, pages 8466 - 71
RODOLFO ET AL., IMMUNOLOGY LETTERS, 1999, pages 47 - 52
SATO ET AL., CANCER RES., vol. 53, 1993, pages 851 - 6
SCHENK B. ET AL., THE JOURNAL OF CLINICAL INVESTIGATION, vol. 108, no. 11, 2001, pages 1687 - 95
See also references of EP2196541A4
SUSUMU ET AL., NATURE, vol. 315, 1985, pages 592 - 4
TSURUSHITA N.; HINTON P. R.; KUMAR S.: "Design of humanized antibodies: from anti-Tac to Zenapax", METHODS, vol. 36, no. 1, 2005, pages 69 - 83
VAISITTI T.; DEAGLIO S.; MALAVASI F.: "Cationization of monoclonal antibodies: another step towards the "magic bullet"", J. BIOL. REGUL HOMOEST. AGENTS, vol. 19, no. 3-4, 2005, pages 105 - 12
VALLE ET AL., NATURE, vol. 291, 1981, pages 338 - 340
VAUGHAN ET AL., NATURE BIOTECHNOLOGY, vol. 14, 1996, pages 309 - 14
WATERHOUSES ET AL., NUCLEIC ACIDS RES., vol. 21, 1993, pages 2265 - 6
WEITZHANDLER M. ET AL., JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 83, no. 12, 1994, pages 1670 - 5
YAGI T., PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 9918 - 22
YAMASAKI Y.; SUMIMOTO K.; NISHIKAWA M.; YAMASHITA F.; YAMAOKA K.; HASHIDA M.; TAKAKURA Y.: "Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: importance of molecular size and negative charge density for in vivo recognition by receptors", PHARMACOL. EXP. THER., vol. 301, no. 2, 2002, pages 467 - 77
ZUCKIER L. S.; CHANG C. J.; SCHARFF M. D.; MORRISON S. L.: "Chimeric human-mouse IgG antibodies with shuffled constant region exons demonstrate that multiple domains contribute to in vivo half-life", CANCER RES., vol. 58, no. 17, 1998, pages 3905 - 8

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US20150315278A1 (en) 2015-11-05
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