WO2009037861A1 - β-グルクロニダーゼ阻害剤 - Google Patents

β-グルクロニダーゼ阻害剤 Download PDF

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Publication number
WO2009037861A1
WO2009037861A1 PCT/JP2008/002602 JP2008002602W WO2009037861A1 WO 2009037861 A1 WO2009037861 A1 WO 2009037861A1 JP 2008002602 W JP2008002602 W JP 2008002602W WO 2009037861 A1 WO2009037861 A1 WO 2009037861A1
Authority
WO
WIPO (PCT)
Prior art keywords
specific
glucuronidase inhibitor
macrocyclic
ketone
glucuronidase
Prior art date
Application number
PCT/JP2008/002602
Other languages
English (en)
French (fr)
Inventor
Ichirou Mori
Syunichi Akiba
Original Assignee
Kao Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corporation filed Critical Kao Corporation
Priority to JP2009533068A priority Critical patent/JP5548451B2/ja
Priority to KR1020107004774A priority patent/KR101530398B1/ko
Priority to EP08831650.0A priority patent/EP2192178B1/en
Priority to CN2008801080468A priority patent/CN101802189B/zh
Priority to US12/679,244 priority patent/US9200269B2/en
Publication of WO2009037861A1 publication Critical patent/WO2009037861A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

　特定の大環状ケトン、ケトン、大環状ラクトン、大環状オキサラクトン、エステル、アルデヒド、アルコール及びテルペンから選ばれる化合物からなる新規β-グルクロニダーゼ阻害剤、並びに当該-βグルクロニダーゼ阻害剤を含有する環境衛生製品及びサニタリー製品。並びにβ-グルクロニダーゼ阻害剤を使用した尿臭生成抑制用組成物及び尿臭の生成抑制方法。
PCT/JP2008/002602 2007-09-20 2008-09-19 β-グルクロニダーゼ阻害剤 WO2009037861A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2009533068A JP5548451B2 (ja) 2007-09-20 2008-09-19 β−グルクロニダーゼ阻害剤
KR1020107004774A KR101530398B1 (ko) 2007-09-20 2008-09-19 β-글루쿠로니다아제 저해제
EP08831650.0A EP2192178B1 (en) 2007-09-20 2008-09-19 B-glucuronidase inhibitor
CN2008801080468A CN101802189B (zh) 2007-09-20 2008-09-19 β-葡萄糖醛酸苷酶抑制剂
US12/679,244 US9200269B2 (en) 2007-09-20 2008-09-19 β-glucuronidase inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007243661 2007-09-20
JP2007-243661 2007-09-20

Publications (1)

Publication Number Publication Date
WO2009037861A1 true WO2009037861A1 (ja) 2009-03-26

Family

ID=40467687

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/002602 WO2009037861A1 (ja) 2007-09-20 2008-09-19 β-グルクロニダーゼ阻害剤

Country Status (6)

Country Link
US (1) US9200269B2 (ja)
EP (1) EP2192178B1 (ja)
JP (2) JP5548451B2 (ja)
KR (1) KR101530398B1 (ja)
CN (1) CN101802189B (ja)
WO (1) WO2009037861A1 (ja)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011229894A (ja) * 2010-04-06 2011-11-17 Kao Corp 尿臭生成抑制用組成物
WO2012023444A1 (ja) * 2010-08-18 2012-02-23 住友精化株式会社 吸水性樹脂組成物、吸収体及び吸収性物品
WO2012115238A1 (ja) * 2011-02-25 2012-08-30 花王株式会社 尿臭発生部の視覚的判定方法
JP2013252451A (ja) * 2013-08-29 2013-12-19 Kao Corp β−グルクロニダーゼ阻害剤
JP2014144942A (ja) * 2013-01-30 2014-08-14 Kao Corp 過活動膀胱の予防又は改善剤
JP2015211667A (ja) * 2014-04-14 2015-11-26 花王株式会社 尿臭抑制剤の探索方法
JP2015224273A (ja) * 2014-05-27 2015-12-14 花王株式会社 衣料用臭気抑制剤組成物
JP2016528318A (ja) * 2013-06-17 2016-09-15 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ 活性分子を制御放出するための化合物
JP2017039871A (ja) * 2015-08-20 2017-02-23 花王株式会社 粉末洗濯前処理剤組成物
WO2017090518A1 (ja) * 2015-11-24 2017-06-01 花王株式会社 尿臭抑制剤
JP2017101224A (ja) * 2015-11-24 2017-06-08 花王株式会社 尿臭抑制剤
JP2018051555A (ja) * 2016-09-21 2018-04-05 三洋化成工業株式会社 吸着剤組成物及びそれを用いた有害物質の吸着方法
JP2021069330A (ja) * 2019-10-31 2021-05-06 花王株式会社 インドール臭抑制剤の選択方法
WO2021106822A1 (ja) 2019-11-25 2021-06-03 花王株式会社 分岐脂肪酸の代謝制御方法

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WO2015017603A1 (en) 2013-08-01 2015-02-05 The Procter & Gamble Company Articles comprising malodor reduction compositions
US20170340905A1 (en) * 2014-12-18 2017-11-30 Firmenich Sa Macrocyclic ketone as malodor counteracting ingredient
EP3662751B1 (en) * 2015-05-26 2021-10-13 Kaohsiung Medical University Pyrazolo[4,3-c]quinoline derivatives for inhibition of b-glucuronidase
KR101822929B1 (ko) 2016-05-16 2018-01-29 윤혜진 의류 및 섬유용 탈취제 및 이의 제조방법
CN106822070A (zh) * 2017-01-22 2017-06-13 新乡医学院 一种治疗动脉粥样硬化的药物组合物与应用
JP7321809B2 (ja) * 2018-07-13 2023-08-07 花王株式会社 臭いの生成抑制方法
CN111122268A (zh) * 2019-12-31 2020-05-08 华南理工大学 一种保存液体样品中硫酸酯结合体和葡萄糖苷醛酸结合体的方法
CN111419843B (zh) * 2020-05-14 2021-07-27 浙江工业大学 氰基亚胺噻唑烷呋喃甲酰胺类化合物在制备β-葡萄糖醛酸苷酶抑制剂中的应用
CN113384562B (zh) * 2021-04-07 2022-05-24 浙江工业大学 一种二萜类化合物在制备β-葡萄糖醛酸苷酶活性抑制剂中的应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0543469A (ja) * 1991-08-09 1993-02-23 Tsumura & Co β−グルクロニダーゼ阻害剤
JPH0930944A (ja) * 1995-07-21 1997-02-04 Pola Chem Ind Inc 芳香剤及びこれを含有する衣類
JP2002255776A (ja) 2001-03-01 2002-09-11 Kao Corp デオドラント剤
JP2003501384A (ja) * 1999-06-07 2003-01-14 ペー アー ツェット アルツナイミッテルエントヴィックルングスゲゼルシャフト ミット ベシュレンクテル ハフツング ヒトの組織におけるβ−グルクロニダーゼの阻害作用を有する薬剤の製造のためのベラパミル及びベラパミル誘導体の使用
JP2005162756A (ja) 2003-11-05 2005-06-23 Katsutoshi Terasawa β−グルクロニダーゼ阻害剤
JP2006045188A (ja) * 2004-02-23 2006-02-16 Nagase & Co Ltd β−グルクロニダーゼ阻害剤
JP2007518814A (ja) * 2004-01-20 2007-07-12 ザ・スクリップス・リサーチ・インスティテュート グリコシダーゼ阻害剤によるほ乳類での変性軟骨症の治療
JP2007176868A (ja) * 2005-12-28 2007-07-12 Nagase Chemtex Corp β−グルクロニダーゼ阻害剤

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2599257B1 (fr) * 1986-05-29 1989-12-29 Robertet Sa Agent neutralisant les odeurs desagreables des excretions et excrements des animaux.
JP3265596B2 (ja) 1991-11-19 2002-03-11 松下電器産業株式会社 悪臭発生防止部材
JPH0747108A (ja) 1993-06-04 1995-02-21 Nippon Flour Mills Co Ltd ウレアーゼ阻害剤及び消臭剤
JPH0819595A (ja) 1994-07-05 1996-01-23 Maruzen Pharmaceut Co Ltd アンモニア発生防止剤
EP0958833A1 (en) 1998-05-20 1999-11-24 Erasmus Universiteit Rotterdam Methods and means for preventing or treating inflammation
US6379658B1 (en) * 1999-12-21 2002-04-30 International Flavors & Fragrances Inc. Human sweat malodor counteractant composition and process for using same
EP1201738A1 (en) * 2000-10-30 2002-05-02 Pfw Aroma Chemicals B.V. Fragrance composition comprising cyclohexadecanone
JP2003183697A (ja) * 2001-12-20 2003-07-03 Lion Corp トイレ用洗浄剤組成物
US7763238B2 (en) * 2002-01-16 2010-07-27 Monell Chemical Senses Center Olfactory adaptation and cross-adapting agents to reduce the perception of body odors
EP1342775B1 (en) 2002-03-08 2005-08-24 Firmenich Sa Hetero spiro compound as perfuming and flavoring ingredient
JP4450355B2 (ja) 2002-08-29 2010-04-14 丸善製薬株式会社 ウレアーゼ阻害剤、アンモニア臭抑制剤およびおむつかぶれ防止剤
JP2004180979A (ja) 2002-12-04 2004-07-02 Ogawa & Co Ltd 抗菌消臭剤組成物
US20040223871A1 (en) * 2003-05-05 2004-11-11 The Procter & Gamble Company Method of freshening air
BRPI0410146B8 (pt) * 2003-05-09 2021-06-22 Givaudan Sa método para neutralizar ou reduzir odores associados em uso com um artigo selecionado dentre toalhas ou absorventes higiênicos e protetores de calcinha, uso de uma composição de materiais de fragrância, artigo, e, composição de materiais de fragrância para neutralizar ou reduzir odores associados com fluidos corporais femininos
JP2005065750A (ja) 2003-08-27 2005-03-17 Takasago Internatl Corp 消臭剤含有製品
JP4808633B2 (ja) * 2004-11-12 2011-11-02 高砂香料工業株式会社 光学活性ムスコン組成物、およびそれを含有する香粧品
JP2006149893A (ja) 2004-11-30 2006-06-15 Lion Corp 尿臭抑制方法
JP2006192127A (ja) 2005-01-14 2006-07-27 Toto Ltd 防臭方法
JP2006255290A (ja) 2005-03-18 2006-09-28 Seiko Pmc Corp 界面活性剤、防臭剤、防臭材、及び防臭方法
JP4727334B2 (ja) 2005-07-22 2011-07-20 長谷川香料株式会社 透明乃至半透明ゲル状芳香剤組成物
EP1767185B2 (en) * 2005-09-23 2018-11-28 Takasago International Corporation Core shell capsules containing an oil or waxy solid
JP2008173441A (ja) 2006-12-22 2008-07-31 Kao Corp 揮発性硫黄化合物生成抑制剤

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0543469A (ja) * 1991-08-09 1993-02-23 Tsumura & Co β−グルクロニダーゼ阻害剤
JPH0798752B2 (ja) 1991-08-09 1995-10-25 株式会社ツムラ β−グルクロニダーゼ阻害剤
JPH0930944A (ja) * 1995-07-21 1997-02-04 Pola Chem Ind Inc 芳香剤及びこれを含有する衣類
JP2003501384A (ja) * 1999-06-07 2003-01-14 ペー アー ツェット アルツナイミッテルエントヴィックルングスゲゼルシャフト ミット ベシュレンクテル ハフツング ヒトの組織におけるβ−グルクロニダーゼの阻害作用を有する薬剤の製造のためのベラパミル及びベラパミル誘導体の使用
JP2002255776A (ja) 2001-03-01 2002-09-11 Kao Corp デオドラント剤
JP2005162756A (ja) 2003-11-05 2005-06-23 Katsutoshi Terasawa β−グルクロニダーゼ阻害剤
JP2007518814A (ja) * 2004-01-20 2007-07-12 ザ・スクリップス・リサーチ・インスティテュート グリコシダーゼ阻害剤によるほ乳類での変性軟骨症の治療
JP2006045188A (ja) * 2004-02-23 2006-02-16 Nagase & Co Ltd β−グルクロニダーゼ阻害剤
JP2007176868A (ja) * 2005-12-28 2007-07-12 Nagase Chemtex Corp β−グルクロニダーゼ阻害剤

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DONG-HYUN KIM ET AL., ARCH PHARM RES, vol. 24, 2001, pages 564 - 567
See also references of EP2192178A4 *
Z. WALASZEK, CANCER LETTERS, vol. 54, 1990, pages 1 - 8

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011229894A (ja) * 2010-04-06 2011-11-17 Kao Corp 尿臭生成抑制用組成物
WO2012023444A1 (ja) * 2010-08-18 2012-02-23 住友精化株式会社 吸水性樹脂組成物、吸収体及び吸収性物品
WO2012115238A1 (ja) * 2011-02-25 2012-08-30 花王株式会社 尿臭発生部の視覚的判定方法
JP2012187101A (ja) * 2011-02-25 2012-10-04 Kao Corp 尿臭発生部の視覚的判定方法
RU2598718C2 (ru) * 2011-02-25 2016-09-27 Као Корпорейшн Способ визуального определения местонахождения источника образования запаха мочи и скрининг ингибиторов образования запаха мочи
JP2014144942A (ja) * 2013-01-30 2014-08-14 Kao Corp 過活動膀胱の予防又は改善剤
JP2016528318A (ja) * 2013-06-17 2016-09-15 フイルメニツヒ ソシエテ アノニムＦｉｒｍｅｎｉｃｈ Ｓａ 活性分子を制御放出するための化合物
US10590365B2 (en) 2013-06-17 2020-03-17 Firmenich Sa Compounds for a controlled release of active molecules
JP2013252451A (ja) * 2013-08-29 2013-12-19 Kao Corp β−グルクロニダーゼ阻害剤
JP2015211667A (ja) * 2014-04-14 2015-11-26 花王株式会社 尿臭抑制剤の探索方法
JP2015224273A (ja) * 2014-05-27 2015-12-14 花王株式会社 衣料用臭気抑制剤組成物
JP2017039871A (ja) * 2015-08-20 2017-02-23 花王株式会社 粉末洗濯前処理剤組成物
WO2017090518A1 (ja) * 2015-11-24 2017-06-01 花王株式会社 尿臭抑制剤
JP2017101224A (ja) * 2015-11-24 2017-06-08 花王株式会社 尿臭抑制剤
CN108289973A (zh) * 2015-11-24 2018-07-17 花王株式会社 尿臭抑制剂
JP2018051555A (ja) * 2016-09-21 2018-04-05 三洋化成工業株式会社 吸着剤組成物及びそれを用いた有害物質の吸着方法
JP2021069330A (ja) * 2019-10-31 2021-05-06 花王株式会社 インドール臭抑制剤の選択方法
JP7383453B2 (ja) 2019-10-31 2023-11-20 花王株式会社 インドール臭抑制剤の選択方法
WO2021106822A1 (ja) 2019-11-25 2021-06-03 花王株式会社 分岐脂肪酸の代謝制御方法

Also Published As

Publication number Publication date
EP2192178A4 (en) 2010-10-27
JP5548451B2 (ja) 2014-07-16
CN101802189A (zh) 2010-08-11
JPWO2009037861A1 (ja) 2011-01-06
JP5719951B2 (ja) 2015-05-20
JP2014195696A (ja) 2014-10-16
US20100247475A1 (en) 2010-09-30
KR101530398B1 (ko) 2015-06-19
CN101802189B (zh) 2013-03-27
EP2192178A1 (en) 2010-06-02
EP2192178B1 (en) 2015-11-18
US9200269B2 (en) 2015-12-01
KR20100056484A (ko) 2010-05-27

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