WO2009020093A1 - デスドメイン含有受容体発現細胞にアポトーシスを誘導するイムノリポソーム - Google Patents

デスドメイン含有受容体発現細胞にアポトーシスを誘導するイムノリポソーム Download PDF

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Publication number
WO2009020093A1
WO2009020093A1 PCT/JP2008/063958 JP2008063958W WO2009020093A1 WO 2009020093 A1 WO2009020093 A1 WO 2009020093A1 JP 2008063958 W JP2008063958 W JP 2008063958W WO 2009020093 A1 WO2009020093 A1 WO 2009020093A1
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WO
WIPO (PCT)
Prior art keywords
immunoliposome
cell expressing
death domain
containing receptor
inducing apoptosis
Prior art date
Application number
PCT/JP2008/063958
Other languages
English (en)
French (fr)
Inventor
Koji Morita
Takako Niwa
Kimihisa Ichikawa
Hiroko Yoshida
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Priority to EP08792162A priority Critical patent/EP2177230A4/en
Priority to JP2009526446A priority patent/JPWO2009020093A1/ja
Priority to CN200880110766A priority patent/CN101820913A/zh
Priority to CA2695991A priority patent/CA2695991A1/en
Priority to US12/672,870 priority patent/US20100209490A1/en
Publication of WO2009020093A1 publication Critical patent/WO2009020093A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A61K47/6913—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

　本発明は、癌、自己免疫疾患または炎症性疾患に対して治療効果を有するイムノリポソーム製剤に関する。すなわち、本発明は、デスドメイン含有受容体発現細胞にアポトーシスを誘導可能な抗体を構成成分とするイムノリポソームに関する。
PCT/JP2008/063958 2007-08-09 2008-08-04 デスドメイン含有受容体発現細胞にアポトーシスを誘導するイムノリポソーム WO2009020093A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08792162A EP2177230A4 (en) 2007-08-09 2008-08-04 IMMUNOLIPOSOM AS INDUCTOR OF APOPTOSIS INTO DEATH DOMAIN-CONTAINING RECEPTOR EXPRESSING CELL
JP2009526446A JPWO2009020093A1 (ja) 2007-08-09 2008-08-04 デスドメイン含有受容体発現細胞にアポトーシスを誘導するイムノリポソーム
CN200880110766A CN101820913A (zh) 2007-08-09 2008-08-04 在表达含死亡结构域的受体的细胞中诱导细胞凋亡的免疫脂质体
CA2695991A CA2695991A1 (en) 2007-08-09 2008-08-04 Immunoliposome inducing apoptosis into cell expressing death domain-containing receptor
US12/672,870 US20100209490A1 (en) 2007-08-09 2008-08-04 Immunoliposome inducing apoptosis into cell expressing death domain-containing receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007208664 2007-08-09
JP2007-208664 2007-08-09

Publications (1)

Publication Number Publication Date
WO2009020093A1 true WO2009020093A1 (ja) 2009-02-12

Family

ID=40341326

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2008/063959 WO2009020094A1 (ja) 2007-08-09 2008-08-04 疎水性分子で修飾した抗体
PCT/JP2008/063958 WO2009020093A1 (ja) 2007-08-09 2008-08-04 デスドメイン含有受容体発現細胞にアポトーシスを誘導するイムノリポソーム

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/063959 WO2009020094A1 (ja) 2007-08-09 2008-08-04 疎水性分子で修飾した抗体

Country Status (8)

Country Link
US (2) US20110269942A1 (ja)
EP (2) EP2184355A4 (ja)
JP (2) JPWO2009020094A1 (ja)
KR (1) KR20100046185A (ja)
CN (1) CN101820913A (ja)
CA (1) CA2695991A1 (ja)
TW (2) TW200916477A (ja)
WO (2) WO2009020094A1 (ja)

Cited By (11)

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Publication number Priority date Publication date Assignee Title
US20100209490A1 (en) * 2007-08-09 2010-08-19 Daiichi Sankyo Company, Limited Immunoliposome inducing apoptosis into cell expressing death domain-containing receptor
JP2011032264A (ja) * 2009-07-06 2011-02-17 Canon Inc 標識タンパク質及びその取得方法
WO2014050779A1 (ja) * 2012-09-25 2014-04-03 第一三共株式会社 Ｇｓｋ３阻害剤と抗ｄｒ５抗体の組み合わせ
JPWO2012093733A1 (ja) * 2011-01-07 2014-06-09 セイコーエプソン株式会社 抗シグナルペプチド抗体の製造方法
EP2480230A4 (en) * 2009-09-24 2015-06-10 Seattle Genetics Inc LIGAND-DRUG CONJUGATES DR5
US9238796B2 (en) 2010-06-04 2016-01-19 Toagosei Co. Ltd. Cell growth-promoting peptide and use thereof
US9370182B2 (en) 2012-05-28 2016-06-21 Toagosei Co., Ltd. Antimicrobial peptide and use thereof
US9480727B2 (en) 2012-10-18 2016-11-01 Toagosei Co. Ltd. Synthetic peptide for inhibiting expression of type 2 TNF receptor and use thereof
CN107753434A (zh) * 2017-12-06 2018-03-06 西南交通大学 一种包载亲疏水性不同药物的载药脂质体及其制备方法与应用
JP2021514945A (ja) * 2018-02-26 2021-06-17 アイジーエム バイオサイエンシズ インコーポレイテッド がんを治療するための、化学療法剤と併用した多量体抗ｄｒ５結合分子の使用
WO2023204290A1 (ja) * 2022-04-21 2023-10-26 愛知県 多重特異性ナノ粒子

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CA3008392C (en) 2015-12-17 2021-11-09 The Johns Hopkins University Ameliorating systemic sclerosis with death receptor agonists
JP7281795B2 (ja) 2016-04-07 2023-05-26 ザ・ジョンズ・ホプキンス・ユニバーシティー 膵炎および疼痛をデス受容体アゴニストで処置するための組成物および方法
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WO2019032585A1 (en) * 2017-08-09 2019-02-14 The Regents Of The University Of Michigan STRUCTURES IMITATING APOPTOSIS
CN112292138A (zh) 2018-01-22 2021-01-29 西雅图儿童医院（Dba西雅图儿童研究所） Car t细胞的使用方法
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Cited By (16)

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US20110269942A1 (en) * 2007-08-09 2011-11-03 Daiichi Sankyo Company, Limited Antibodies modified with hydrophobic molecule
US20100209490A1 (en) * 2007-08-09 2010-08-19 Daiichi Sankyo Company, Limited Immunoliposome inducing apoptosis into cell expressing death domain-containing receptor
JP2011032264A (ja) * 2009-07-06 2011-02-17 Canon Inc 標識タンパク質及びその取得方法
US8993715B2 (en) 2009-07-06 2015-03-31 Canon Kabushiki Kaisha Labeled protein and method for obtaining the same
EP2480230A4 (en) * 2009-09-24 2015-06-10 Seattle Genetics Inc LIGAND-DRUG CONJUGATES DR5
US9238796B2 (en) 2010-06-04 2016-01-19 Toagosei Co. Ltd. Cell growth-promoting peptide and use thereof
JP5855583B2 (ja) * 2011-01-07 2016-02-09 セイコーエプソン株式会社 抗シグナルペプチド抗体の製造方法
JPWO2012093733A1 (ja) * 2011-01-07 2014-06-09 セイコーエプソン株式会社 抗シグナルペプチド抗体の製造方法
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WO2014050779A1 (ja) * 2012-09-25 2014-04-03 第一三共株式会社 Ｇｓｋ３阻害剤と抗ｄｒ５抗体の組み合わせ
US9480727B2 (en) 2012-10-18 2016-11-01 Toagosei Co. Ltd. Synthetic peptide for inhibiting expression of type 2 TNF receptor and use thereof
CN107753434A (zh) * 2017-12-06 2018-03-06 西南交通大学 一种包载亲疏水性不同药物的载药脂质体及其制备方法与应用
JP2021514945A (ja) * 2018-02-26 2021-06-17 アイジーエム バイオサイエンシズ インコーポレイテッド がんを治療するための、化学療法剤と併用した多量体抗ｄｒ５結合分子の使用
JP7358365B2 (ja) 2018-02-26 2023-10-10 アイジーエム バイオサイエンシズ インコーポレイテッド がんを治療するための、化学療法剤と併用した多量体抗ｄｒ５結合分子の使用
WO2023204290A1 (ja) * 2022-04-21 2023-10-26 愛知県 多重特異性ナノ粒子

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Publication number Publication date
KR20100046185A (ko) 2010-05-06
EP2184355A1 (en) 2010-05-12
EP2184355A4 (en) 2011-04-27
US20110269942A1 (en) 2011-11-03
TW200914064A (en) 2009-04-01
TW200916477A (en) 2009-04-16
EP2177230A1 (en) 2010-04-21
US20100209490A1 (en) 2010-08-19
EP2177230A4 (en) 2011-04-27
CA2695991A1 (en) 2009-02-12
WO2009020094A1 (ja) 2009-02-12
JPWO2009020094A1 (ja) 2010-11-04
JPWO2009020093A1 (ja) 2010-11-04
CN101820913A (zh) 2010-09-01

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