WO2008009053A1 - Agent de nettoyage à faible moussage - Google Patents

Agent de nettoyage à faible moussage Download PDF

Info

Publication number
WO2008009053A1
WO2008009053A1 PCT/AU2007/000999 AU2007000999W WO2008009053A1 WO 2008009053 A1 WO2008009053 A1 WO 2008009053A1 AU 2007000999 W AU2007000999 W AU 2007000999W WO 2008009053 A1 WO2008009053 A1 WO 2008009053A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition according
liquid composition
hydrotrope
glycol ether
cleaning
Prior art date
Application number
PCT/AU2007/000999
Other languages
English (en)
Inventor
Steven Kritzler
Alex Sava
Original Assignee
Novapharm Research (Australia) Pty Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2006903863A external-priority patent/AU2006903863A0/en
Priority to EP20070763784 priority Critical patent/EP2052069B1/fr
Priority to ES07763784T priority patent/ES2450742T3/es
Priority to AU2007276698A priority patent/AU2007276698B2/en
Priority to KR1020097003285A priority patent/KR101399218B1/ko
Priority to CN2007800271529A priority patent/CN101490233B/zh
Priority to BRPI0713197A priority patent/BRPI0713197B1/pt
Priority to US12/374,157 priority patent/US9023778B2/en
Application filed by Novapharm Research (Australia) Pty Limited filed Critical Novapharm Research (Australia) Pty Limited
Priority to JP2009519747A priority patent/JP5479894B2/ja
Priority to DK07763784T priority patent/DK2052069T3/da
Priority to MX2009000564A priority patent/MX2009000564A/es
Priority to CA2657820A priority patent/CA2657820C/fr
Publication of WO2008009053A1 publication Critical patent/WO2008009053A1/fr
Priority to IL19654909A priority patent/IL196549A/en
Priority to ZA2009/01117A priority patent/ZA200901117B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38618—Protease or amylase in liquid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0026—Low foaming or foam regulating compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/34—Organic compounds containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/40—Products in which the composition is not well defined
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/50—Solvents
    • C11D7/5004—Organic solvents
    • C11D7/5022—Organic solvents containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/14—Hard surfaces
    • C11D2111/20—Industrial or commercial equipment, e.g. reactors, tubes or engines
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
    • C11D7/22—Organic compounds
    • C11D7/26—Organic compounds containing oxygen
    • C11D7/263—Ethers

Definitions

  • This invention relates to a composition for use for general cleaning, and in particular for use in cleaning medical instruments and which is effective for soil removal and protein digestion while remaining low foaming.
  • a preparation For effective cleaning of medical instruments a preparation should be effective for soil removal, effective for protein digestion and resist foaming. In addition, the products are required to have stability and a long shelf life.
  • Foaming is undesirable because it blocks the visualization of instruments in manual cleaning baths, impedes access of washing liquor to soils during manual cleaning and blocks water jets and washing liquor circulation in automated washers (e.g. tunnel washers).
  • the foams tend to block the lumens of instruments preventing effective cleaning of the lumen interior.
  • enzyme based cleaners have been used in reprocessing machinery the foam tends to fill the volume thus impeding the cleaning cycle by disrupting jets and agitation.
  • Cheetham (Australian Infection Control, Sept 2005, 10, 3, p103-109) compared 17 market leading enzyme based medical instrument cleaners from eight manufacturers (Table 1).
  • a further area where low foaming cleaning compositions are desirable is in the area of air conditioning and cooling.
  • fresh food cool rooms have their temperature controlled by a refrigeration unit fitted with fans which is integral with the room.
  • the fans draw environmental air through a refrigerated cooling coil heat exchanger into the room.
  • the process of cooling the air results in a lowering of humidity with the moisture being condensed onto the cold surfaces of the heat exchanger.
  • biofilm not only reduces heat exchange efficiency, but is a very significant potential source of microbiological contamination into the room and is therefore undesirable.
  • the biofilm may be removed with abrasive brushes or high pressure water. This has proved to be problematic because the spaces between the cooling fins are insufficient to allow efficient brushing and the surface areas so extensive as to make this brushing an extremely tedious process. High pressure water has proven to be undesirable because it damages the cooling fins which are made of thin aluminium sections.
  • the heat exchange coil may be washed with strong alkali or strong acid. This has proved to be problematic because the alkali or acid, whilst eventually removing the biofilm both causes significant corrosive damage to the aluminium fins and the copper refrigeration tubes to which they are attached. This corrosion severely limits the service life of the heat exchange coil.
  • the present invention provides liquid compositions which provide high levels of soil removal, exhibit superior protease stability, and minimize foaming to acceptable levels without leaving undesirable levels of residues.
  • the compositions exhibit very high enzyme shelf life stability.
  • the invention provides a liquid for cleaning, said composition excluding surfactants and comprising one or more enzymes including a protease, a solvent system including a water soluble glycol ether solvent, at least one anionic hydrotrope, and wherein the molar ratio of said at least one hydrotrope to said glycol ether in the composition is selected to preserve the activity of said one or more enzymes.
  • the invention provides a liquid composition for cleaning medical instruments, said composition excluding surfactants and comprising one or more enzymes including a protease, a solvent system including a water soluble glycol ether solvent, at least one anionic hydrotrope, and wherein the molar ratio of said at least one hydrotrope to said glycol ether in the composition is selected to preserve the activity of said one or more enzymes.
  • composition includes several additional hydrolase enzymes in addition to a protease or proteases, said hydrolase enzymes including but not limited to lipases, cellulases and amylases.
  • the hydrotrope is an anionic hydrotrope selected from the group consisting of water soluble anionic hydrotropes of the formula:
  • R 1 and R 2 are independently alkyl groups of from 1 to six carbons, although R 1 or R 2 may optionally be hydrogen.
  • Preferred hydrotropes have a short chain (less than six, and preferably from one to four carbons, and more preferably from one to two carbons).
  • Very highly preferred hydrotropes are water soluble xylene sulfonate (R 1 is methyl, R 2 is methyl) and cumene sulfonate (R 1 is isopropyl, R 2 is hydrogen) salts.
  • compositions according to the invention possess all the above desiderata:
  • the invention provides a composition according to the first aspect wherein the molar ratio of hydrotope: glycol ether is selected to be greater than 1.1 : 1. More preferably the weight ratio of hydrotope: glycol ether is greater than 1.2: 1or better still is greater than 1.5:1.
  • the invention provides a composition according to the first or second aspect in a concentrate adapted to be diluted for use by at least 20 parts of water to 1 part of the concentrate (100 to 1000 parts of water to 1 part of concentrate in preferred embodiments) and wherein the hydrotrope is selected from the group comprising of water soluble aromatic sulfonates with one or more short (C1-C6) side alkyl chains.
  • the invention provides a composition according to the first or second aspect wherein the solvent comprises in combination at least one glycol ether, at least one polyhydric alcohol, and water containing boron or borate ions.
  • the invention provides a composition according to any one of the preceding aspects wherein each component of the composition is selected so as to exclude compounds incorporating an alkyl chain of longer than six carbons.
  • the concentration ratios are critical for prevention of enzyme deterioration on storage.
  • the weight ratio of hydrotrope to proteolytic enzyme to should be between 400:1 and 200:1 , more preferably 300:1 and 350:1 and the concentration of hydrotrope should not exceed 25 %.
  • the molar ratio of glycol ether to polyhydric alcohols is preferably between 0.2:1 and 1 :1
  • compositions of the present invention are particularly suited to cleaning medical instruments, and have been principally described with reference to that use, however, it will be appreciated that the cleaning compositions of the present invention are by no means limited to that use. They may be used in any circumstances where it is desired to clean biological matter from surfaces, including industrial and domestic applications, for example, in cleaning down any wet surface contaminated with proteinaceous materials, or cleaning refrigeration coils.
  • the compositions of the present invention have been found to be especially efficacious for cleaning the interior of cooling towers and the heat exchange surfaces of heat exchange equipment involving water.
  • compositions according to the invention are shown in examples 1 , 2, 3.
  • Example 1 (molar ratio hydrotrope to glycol ether 1.1:1)
  • Comparative examples 4, 5 are similar to example 1 except that the mole ratio of hydrotrope to glycol ether is 1.0:1.0 in example 4; and is 0.9:1 in example 5
  • compositions according to the invention may be stored as concentrates for periods of at least 18 months at 25 0 C and should be diluted by tap water from 20:1 to 1000:1 before use.
  • Table 2 below summarises the performance of the best of the compositions evaluated by Cheetham as referred to above and identified in table 1.
  • Table 2 compares in summary form 12 commercially available cleaners in terms of shelf life protease stability (columns 2 and 3), soil removal efficacy (column 4), residual foam height (column 5) and presence of potential residue.
  • the three most effective commercially available compositions in terms of soil removal were Cidezyme, 3M Rapid 70505 and 3M 70500 all of which scored 10. However, of these 3M Rapid 70500 produced a residual foam height of 500 ml which is unacceptable, while 3M rapid 70505 left an oily residue which is also unsatisfactory.
  • the Cidezyme passed the residual foam height test without any residue. However Cidezyme failed on both the stable and unstable proteases shelf life stability tests.
  • In comparison formulations according to examples 1 , 2, 3 of the invention achieved excellent soil removal and passed each of the tests.
  • Table 3 below shows the results for comparative examples 4 and 5. These examples differ from examples 1 to 3 in that the molar ratio of hydrotrope to glycol ether is not selected to preserve the activity of said one or more enzymes, and is below 1.0:1 and 0.9:1 respectively. This shows that to achieve stability for the compositions exemplified the mole ratio of hydrotrope to glycol ether should be selected to be above 1.1 :1. However the ratio required to be selected could be determined for other compositions within the scope of the invention having regard to the teachings herein disclosed. Table 3
  • Scope This method allows for a qualitative and/or quantitative assessment of the relative efficacy of cleaners and detergents in removing a simulated medical soil.
  • Browne indicator strips STF load check indicators (Albert Browne Ltd Leicester UK) - are designed to ensure and assist in documenting the cleaning efficacy of tunnel washers, single chamber washer-disinfectors, etc.
  • the indicator consists of a plastic substrate, with a patch of protein-based soil applied to both sides. This simulates a very difficult to remove medical soil. The amount of soil remaining on the strip after detergent treatment can be assessed visually.
  • the strips are carefully removed with clean tweezers ensuring that no contact is made with the soiled patch on either side of the strip.
  • the strips were then dipped in clean tap water briefly and then allowed to drip dry. After drying the strips are placed on white paper and photographed for visual assessment.
  • the degree of soil removal is generally measured on a scale of 0 to 10, with 0 being the lowest degree (No visible soil removal) and 10 being the highest degree (complete soil removal).
  • Scope The test allows comparison of ingredients of enzymatic formulations in respect of their ability to preserve protease activity during storage. Enzymatic activity is known to decrease over time due to protein denaturing and auto-proteolysis (self-digestion). These processes are dramatically accelerated by increase in temperature - each 10 degrees temperature rise increases the rate of denaturing by up to 8 times. The loss of proteolytic activity over time is quantified for each product and expressed as percentage for each formulation.
  • Test protease a stable protease (Savinase Ultra 16XL, from Novozymes) is used.
  • Teest B a relatively unstable enzyme (Savinase 16L, from Novazyrnes) is used. If practical, both the well stabilised and a poorly stabilised enzyme are used in the same assay - e.g. Savinase Ultra 16XL AND Savinase 16L from Novozymes.
  • a loss of 5% or less of initial protease activity for both stable and unstable proteases in table 5 is regarded as a "pass".
  • An increase in foam volume was determined by blending for 30 sees using a commercial type blender with glass jar at 25 ⁇ 1°C agitated at ⁇ 6000 rpm, and then measuring the increase in total volume of test fluid including foam.
  • Blender A Moulinex commercial blender was used. The glass jar was volume graduated (20-25mL marks).
  • test liquid into a clean glass bottle or jar and store it at 25° ⁇ 1°C for a minimum of 1 h and a maximum of 2 h in the constant temperature water bath deep enough so that the water level is at least 10 mm above the air/test fluid interface.
  • a residual foam height of less than 100 is accepted as a "pass".
  • Residue Presence Test Scope Report oily residues, if present. Method: Oily residues can be easily observed on glass slides using dissecting microscope and lateral lighting.
  • appended figures 1 - 4 illustrate differences in foaming/residue properties.
  • Figures 1 - 4 simulate normal usage procedures in which a concentrate is measured into a container and then the required amount of water is added. The result is photographed without stirring.
  • Figure 1 shows medical instruments in a container filled with 3M Rapid Multi enzyme Cleaner 70500 - one of the two best performers in the Cheetham study. The instruments are hardly visible because of foam.
  • Figure 2 shows the same product (3M Rapid Multi enzyme Cleaner 70500) in a beaker with a stable volume of foam above the liquid.
  • Figure 3 shows the other of the best performers (3M Rapid 70505). A visible undesirable milky residue is suspended in the cloudy liquid.
  • Figure 4 corresponds to figure 1 when a composition according to the invention (example 2) is employed.
  • the low foaming compositions of the present invention was used to clean a heat exchanger. A two step process was employed.
  • the heat exchanger was sprayed with the enzymatic cleaner of the present invention such as described in Examples 1-3 above.
  • the enzymatic cleaner is typically diluted at a rate of 50 parts water to 1 part enzymatic cleaner for very dirty heat exchangers and up to 100 parts of water to 1 part of enzymatic cleaner for less severely soiled heat exchangers.
  • the cleaner is allowed to soak into the contaminated surface in order to penetrate and digest biological matter.
  • the soaking period is typically between 10 and 20 minutes depending on the depth of soil on the heat exchange surfaces.
  • the heat exchanger was sprayed with low pressure water to remove the digested contaminants without physical damage to the fins.
  • the digested contaminants were readily removed as the amount of foam obstruction of the coils was minimal.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Detergent Compositions (AREA)

Abstract

L'invention concerne des compositions liquides pour le nettoyage, en particulier d'instruments médicaux et de surfaces de conditionnement d'air, ladite composition étant exempte d'agents tensioactifs et contenant une ou plusieurs enzymes comprenant une protéase et facultativement une hydrolase, un système solvant comprenant un solvant éther de glycol soluble dans l'eau, au moins un hydrotrope anionique, le rapport molaire dudit hydrotrope audit éther de glycol dans la composition étant choisi pour conserver l'activité de ladite ou desdites enzymes. L'hydrotrope est avantageusement un hydrotrope anionique choisi dans le groupe constitué par les hydrotropes anioniques solubles dans l'eau de la formule (I) et n'ayant pas de chaîne latérale alkyle de plus de 6 atomes de carbone de longueur, par exemple un sel sulfonate de xylène ou sulfonate de cumène.
PCT/AU2007/000999 2006-07-18 2007-07-18 Agent de nettoyage à faible moussage WO2008009053A1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CA2657820A CA2657820C (fr) 2006-07-18 2007-07-18 Agent de nettoyage a faible moussage
US12/374,157 US9023778B2 (en) 2006-07-18 2007-07-18 Low foaming cleaner
AU2007276698A AU2007276698B2 (en) 2006-07-18 2007-07-18 Low foaming cleaner
KR1020097003285A KR101399218B1 (ko) 2006-07-18 2007-07-18 저 거품 세정제
CN2007800271529A CN101490233B (zh) 2006-07-18 2007-07-18 低泡清洁剂
BRPI0713197A BRPI0713197B1 (pt) 2006-07-18 2007-07-18 composição líquida para a limpeza, método de limpeza de um instrumento médico com necessidade da mesma e método de limpeza de um componente de ar condicionado com necessidade da mesma
JP2009519747A JP5479894B2 (ja) 2006-07-18 2007-07-18 低発泡性洗浄剤
EP20070763784 EP2052069B1 (fr) 2006-07-18 2007-07-18 Agent de nettoyage à faible moussage
ES07763784T ES2450742T3 (es) 2006-07-18 2007-07-18 Detergente poco espumoso
DK07763784T DK2052069T3 (da) 2006-07-18 2007-07-18 Lavt skummende rengøringsmiddel
MX2009000564A MX2009000564A (es) 2006-07-18 2007-07-18 Limpiador de baja espuma.
IL19654909A IL196549A (en) 2006-07-18 2009-01-15 Low-grade foam detergent
ZA2009/01117A ZA200901117B (en) 2006-07-18 2009-02-17 Low foaming cleaner

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AU2006903863A AU2006903863A0 (en) 2006-07-18 Low foaming cleaner for medical instruments
AU2006903863 2006-07-18
AU2007900582 2007-02-07
AU2007900582A AU2007900582A0 (en) 2007-02-07 Low foaming cleaner

Publications (1)

Publication Number Publication Date
WO2008009053A1 true WO2008009053A1 (fr) 2008-01-24

Family

ID=38956429

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2007/000999 WO2008009053A1 (fr) 2006-07-18 2007-07-18 Agent de nettoyage à faible moussage

Country Status (17)

Country Link
US (1) US9023778B2 (fr)
EP (1) EP2052069B1 (fr)
JP (1) JP5479894B2 (fr)
KR (1) KR101399218B1 (fr)
CN (1) CN101490233B (fr)
AR (1) AR061906A1 (fr)
AU (1) AU2007276698B2 (fr)
BR (1) BRPI0713197B1 (fr)
CA (1) CA2657820C (fr)
DK (1) DK2052069T3 (fr)
ES (1) ES2450742T3 (fr)
IL (1) IL196549A (fr)
MX (1) MX2009000564A (fr)
MY (1) MY154966A (fr)
TW (1) TWI485244B (fr)
WO (1) WO2008009053A1 (fr)
ZA (1) ZA200901117B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009121890A1 (fr) * 2008-04-01 2009-10-08 Novozymes A/S Procédé de préparation de pains de savon de ménage avec une stabilité au stockage améliorée
CN102071113A (zh) * 2011-02-05 2011-05-25 徐宏汇 浓缩多酶医疗清洗剂
JP2011519995A (ja) * 2008-05-09 2011-07-14 ノヴァファーム・リサーチ・（オーストラリア）・ピーティーワイ・リミテッド 器具クリーナー
US20130084626A1 (en) * 2010-01-20 2013-04-04 Ecolab Usa Inc. Low and high temperature enzymatic system

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010043934A1 (de) 2010-11-15 2012-05-16 Henkel Ag & Co. Kgaa Stabilisierte flüssige enzymhaltige Tensidzubereitung
CN106488976A (zh) * 2014-05-02 2017-03-08 凯斯医疗有限公司 用于处理潜在的感染性蛋白质污染物的组合物和方法
AU2016218935B2 (en) 2015-02-12 2018-12-20 Whiteley Corporation Pty Ltd Detergent for medical instrumentation
US10183087B2 (en) * 2015-11-10 2019-01-22 American Sterilizer Company Cleaning and disinfecting composition
SG11201806124QA (en) * 2016-01-22 2018-08-30 Novapharm Res Australia Pty Ltd Sanitising composition
JP7219583B2 (ja) 2018-10-19 2023-02-08 大日本除蟲菊株式会社 殺菌剤組成物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1286054A (en) * 1970-05-28 1972-08-16 Colgate Palmolive Co Foam control systems
US5082585A (en) * 1989-02-02 1992-01-21 Lever Brothers Company, Division Of Conopco, Inc. Enzymatic liquid detergent compositions containing nonionic copolymeric stabilizing agents for included lipolytic enzymes
US6083897A (en) * 1998-08-28 2000-07-04 Huntsman Petrochemical Corporation Solubilization of low 2-phenyl alkylbenzene sulfonates
EP1081215A1 (fr) 1999-09-02 2001-03-07 CHEMISCHE FABRIK DR. WEIGERT (GMBH & CO.) Concentré enzymatique et procédé de nettoyage de surfaces

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1590445A (en) * 1976-11-01 1981-06-03 Unilever Ltd Enzymatic liquid composition
DE3639322A1 (de) 1986-11-17 1988-05-26 Henkel Kgaa Verfahren zur reinigung und desinfektion von endoskopen und mittel zur durchfuehrung des verfahrens
US4959179A (en) * 1989-01-30 1990-09-25 Lever Brothers Company Stabilized enzymes liquid detergent composition containing lipase and protease
JPH073733A (ja) 1991-08-26 1995-01-06 Hideo Mori 白線引きロボット
US5437686A (en) * 1994-05-18 1995-08-01 Colgate-Palmolive Co. Peroxygen bleach composition activated by bi and tricyclic diketones
DE19603977A1 (de) 1996-02-05 1997-08-07 Henkel Ecolab Gmbh & Co Ohg Verfahren zur Reinigung und Desinfektion von empfindlichen medizinischen Geräten
DE69813368T2 (de) * 1997-05-16 2004-02-26 The Procter & Gamble Company, Cincinnati Gelförmiges oder flüssiges, mildes Geschirrspülmittel auf der Basis von Mikroemulsionen mit vorteilhaftem Lösevermögen für fettige Speisereste und Schaumverhalten
US5997764A (en) * 1997-12-04 1999-12-07 The B.F. Goodrich Company Thickened bleach compositions
JP2002535439A (ja) 1999-01-20 2002-10-22 ザ、プロクター、エンド、ギャンブル、カンパニー 改質アルキルベンゼンを含む皿洗い用組成物
JP2001031999A (ja) 1999-07-19 2001-02-06 Clean Chemical Kk 洗浄剤組成物
AUPQ679100A0 (en) 2000-04-07 2000-05-11 Novapharm Research (Australia) Pty Ltd Process and composition for cleaning medical instruments
US7569532B2 (en) * 2000-06-29 2009-08-04 Ecolab Inc. Stable liquid enzyme compositions
US6916773B2 (en) * 2002-07-31 2005-07-12 Ecolab, Inc. Non-surfactant solubilizing agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1286054A (en) * 1970-05-28 1972-08-16 Colgate Palmolive Co Foam control systems
US5082585A (en) * 1989-02-02 1992-01-21 Lever Brothers Company, Division Of Conopco, Inc. Enzymatic liquid detergent compositions containing nonionic copolymeric stabilizing agents for included lipolytic enzymes
US6083897A (en) * 1998-08-28 2000-07-04 Huntsman Petrochemical Corporation Solubilization of low 2-phenyl alkylbenzene sulfonates
EP1081215A1 (fr) 1999-09-02 2001-03-07 CHEMISCHE FABRIK DR. WEIGERT (GMBH & CO.) Concentré enzymatique et procédé de nettoyage de surfaces

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEETHAM, AUSTRALIAN INFECTION CONTROL, vol. 10, no. 3, September 2005 (2005-09-01), pages 103 - 109
See also references of EP2052069A4

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009121890A1 (fr) * 2008-04-01 2009-10-08 Novozymes A/S Procédé de préparation de pains de savon de ménage avec une stabilité au stockage améliorée
JP2011519995A (ja) * 2008-05-09 2011-07-14 ノヴァファーム・リサーチ・（オーストラリア）・ピーティーワイ・リミテッド 器具クリーナー
US20130084626A1 (en) * 2010-01-20 2013-04-04 Ecolab Usa Inc. Low and high temperature enzymatic system
CN102071113A (zh) * 2011-02-05 2011-05-25 徐宏汇 浓缩多酶医疗清洗剂

Also Published As

Publication number Publication date
CN101490233B (zh) 2013-07-10
EP2052069A4 (fr) 2010-11-03
US9023778B2 (en) 2015-05-05
ES2450742T3 (es) 2014-03-25
CA2657820A1 (fr) 2008-01-24
TWI485244B (zh) 2015-05-21
IL196549A (en) 2013-05-30
AR061906A1 (es) 2008-10-01
AU2007276698B2 (en) 2012-09-06
EP2052069B1 (fr) 2013-12-11
DK2052069T3 (da) 2014-03-17
MX2009000564A (es) 2009-06-30
IL196549A0 (en) 2009-11-18
BRPI0713197B1 (pt) 2017-03-14
CA2657820C (fr) 2015-09-01
KR101399218B1 (ko) 2014-05-27
KR20090050057A (ko) 2009-05-19
BRPI0713197A2 (pt) 2012-03-20
CN101490233A (zh) 2009-07-22
EP2052069A1 (fr) 2009-04-29
JP2009543904A (ja) 2009-12-10
ZA200901117B (en) 2010-02-24
US20100009884A1 (en) 2010-01-14
MY154966A (en) 2015-08-28
AU2007276698A1 (en) 2008-01-24
TW200811283A (en) 2008-03-01
JP5479894B2 (ja) 2014-04-23

Similar Documents

Publication Publication Date Title
AU2007276698B2 (en) Low foaming cleaner
CA2768903C (fr) Compositions detergentes anticorrosion et leur utilisation dans le nettoyage d'instruments dentaires et medicaux
JP4444463B2 (ja) 食器洗浄方法
CA2991407A1 (fr) Detergent acide
JP5584613B2 (ja) 医療器具の洗浄方法
US20150147802A1 (en) Cleaning agent composition for medical-instrument cleaner
JP5856411B2 (ja) アルマイト用洗浄剤組成物
JP2008535967A (ja) 物品の機械的消毒
WO2008121115A1 (fr) Détergeant enzymatique amélioré
CA2474776C (fr) Nettoyage et desinfection d'instruments et d'appareils chirurgicaux et medicaux
JP2004500472A (ja) タンパク質物質を除去するのに適当な組成物
US8420584B2 (en) Enzymatic detergent
JP2016535110A (ja) 医療機器および器具を洗浄および消毒するためのキットおよび方法
CN103865684A (zh) 医疗器械清洗用复合酶制剂及其制备方法
JP2016210943A (ja) 自動洗浄機用液体洗浄剤組成物および洗浄方法
JPH0920606A (ja) 医療検査用マイクロプレート除菌洗浄剤
US9045718B2 (en) Residue cleaning composition and method
CN116286209A (zh) 一种多酶低泡沫医疗器械清洗剂及其制备方法
JPH04359097A (ja) 洗浄剤組成物
US20150225670A1 (en) Residue cleaning composition and method

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780027152.9

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07763784

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2657820

Country of ref document: CA

Ref document number: MX/A/2009/000564

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 12374157

Country of ref document: US

Ref document number: 2009519747

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007276698

Country of ref document: AU

Ref document number: 574490

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2007763784

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 612/KOLNP/2009

Country of ref document: IN

NENP Non-entry into the national phase

Ref country code: RU

WWE Wipo information: entry into national phase

Ref document number: 1020097003285

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2007276698

Country of ref document: AU

Date of ref document: 20070718

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: PI0713197

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20090119