WO2006075558A1 - 卵由来の骨強化組成物 - Google Patents
卵由来の骨強化組成物 Download PDFInfo
- Publication number
- WO2006075558A1 WO2006075558A1 PCT/JP2006/300082 JP2006300082W WO2006075558A1 WO 2006075558 A1 WO2006075558 A1 WO 2006075558A1 JP 2006300082 W JP2006300082 W JP 2006300082W WO 2006075558 A1 WO2006075558 A1 WO 2006075558A1
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- WO
- WIPO (PCT)
- Prior art keywords
- bone
- egg yolk
- protein hydrolyzate
- egg
- yolk protein
- Prior art date
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- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
- A47J37/00—Baking; Roasting; Grilling; Frying
- A47J37/12—Deep fat fryers, e.g. for frying fish or chips
- A47J37/1223—Deep fat fryers, e.g. for frying fish or chips with means for filtering the frying liquid
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
- A47J37/00—Baking; Roasting; Grilling; Frying
- A47J37/12—Deep fat fryers, e.g. for frying fish or chips
- A47J37/1266—Control devices, e.g. to control temperature, level or quality of the frying liquid
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
- A47J37/00—Baking; Roasting; Grilling; Frying
- A47J37/12—Deep fat fryers, e.g. for frying fish or chips
- A47J37/1271—Accessories
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
- A47J37/00—Baking; Roasting; Grilling; Frying
- A47J37/12—Deep fat fryers, e.g. for frying fish or chips
- A47J37/1276—Constructional details
- A47J37/1285—Valves or arrangements to drain used oil or food particles settled at the bottom of the frying vessel
Definitions
- Patent Document 1 a chicken egg (Patent Document 1) reinforced with vitamins and an oyster extract (Patent Document 2) reinforced with zinc are used, a milk-derived basic protein. Products that use quality (Patent Documents 3 and 4) have been developed.
- Patent Document 2 JP 2002-80380 A
- the present invention provides a novel food material that has a bone strengthening action, is safe and inexpensive, and can be widely used in foods and drinks as a bone strengthening agent that can be ingested on a daily basis. This is an issue.
- FIG. 4 is a diagram showing the results of molecular weight analysis of gel yolk protein hydrolyzate obtained in Example 2 by gel filtration chromatography. The shaded area indicates the molecular weight of 500 to 20,000.
- the egg yolk protein hydrolyzate obtained as described above is subjected to molecular weight distribution analysis by gel filtration chromatography and has a molecular weight of 500 or more to the total area ratio of protein / peptide / amino acid. It is important that the area ratio of the portion of 000 or less occupies 50% or more, and it is more preferable that the area ratio occupies 55% or more. In particular, the area ratio occupies 65% or more. If the molecular weight distribution is out of the above range, the effect will be reduced or lost, and denaturation or aggregation due to heating will easily occur. However, as long as the distribution satisfies the above range, 10 to 20% by mass of undegraded egg yolk protein may remain.
- the present bone strengthening composition will be added to the food at a high concentration. Since it affects the sex, it is not preferable.
- the bone-strengthening composition of the present invention is not only added to food and drink, but also prepared in various forms according to the dosage form, and can also be used as a powder (or granule), a drink, a tablet, a capsule, and the like.
- eggs are safe ingredients that have been eaten for a long time, they can be used in medicines or feeds as ingredients without any side-effect problems even if they are used continuously.
- Figure 3 shows the bone elongation rate (%) obtained when egg yolk protein hydrolyzate was administered with the yolk protein hydrolyzate administered as a force (control). Shown in From FIG. 3, it was confirmed that when egg yolk protein hydrolyzate was administered, there was a bone growth promoting effect in which the interval between the two fluorescent bands was 31% wider than that of the control.
- Test 2 (calcification promoting effect)
- Mouse osteoblast MC3T3-E1 cells are cultured in ⁇ -MEM culture medium containing 10% FBS at 37 ° C under 5% CO -95% air until confluent, then trypsin
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Animal Husbandry (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006552899A JP5213332B2 (ja) | 2005-01-11 | 2006-01-06 | 卵由来の骨強化組成物 |
| CN2006800020935A CN101188949B (zh) | 2005-01-11 | 2006-01-06 | 源自蛋的骨强化组合物 |
| KR1020077017967A KR101156703B1 (ko) | 2005-01-11 | 2006-01-06 | 계란유래의 뼈 강화 조성물 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005003628 | 2005-01-11 | ||
| JP2005-003628 | 2005-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2006075558A1 true WO2006075558A1 (ja) | 2006-07-20 |
Family
ID=36677583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2006/300082 WO2006075558A1 (ja) | 2005-01-11 | 2006-01-06 | 卵由来の骨強化組成物 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP5213332B2 (ko) |
| KR (2) | KR20060082015A (ko) |
| CN (1) | CN101188949B (ko) |
| WO (1) | WO2006075558A1 (ko) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011122127A1 (ja) * | 2010-03-31 | 2011-10-06 | 株式会社ファーマフーズ | 骨芽細胞増殖促進活性を有するペプチドおよびその利用 |
| WO2014007318A1 (ja) * | 2012-07-06 | 2014-01-09 | 株式会社ファーマフーズ | 軟骨細胞増殖促進剤 |
| KR20170045275A (ko) | 2014-10-31 | 2017-04-26 | 가부시키 가이샤 파마푸즈 | 발모 및 육모 촉진제 및 이들의 이용 |
| WO2018003817A1 (ja) * | 2016-06-27 | 2018-01-04 | 株式会社ファーマフーズ | 骨形成不全症等の予防及び／又は治療剤 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090246319A1 (en) * | 2008-03-31 | 2009-10-01 | Kraft Foods Holdings, Inc. | Process And Formulation For Making An Egg Product With Increased Functionality And Flavor |
| CN102578360A (zh) * | 2011-01-06 | 2012-07-18 | 盐城市方圆食品有限公司 | 一种高水解低胆固醇鸡蛋蛋白质氨基酸液的制备方法 |
| CN103114117B (zh) * | 2013-01-24 | 2015-08-05 | 中国海洋大学 | 一种具有抗骨质疏松症作用的鱼卵糖蛋白的制备方法 |
| CN107969649A (zh) * | 2017-11-28 | 2018-05-01 | 广州白云山汉方现代药业有限公司 | 一种补钙组合物及制备方法 |
| CN109125704A (zh) * | 2018-11-01 | 2019-01-04 | 北京市蜂业公司 | 蜂王浆牦牛骨小分子肽及其制备方法和应用 |
| KR20230131437A (ko) * | 2022-03-04 | 2023-09-13 | (주)메디언스 | 난황 단백질 유래 키 성장 및 골 밀도 증가용 조성물 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08256698A (ja) * | 1995-03-24 | 1996-10-08 | Taiyo Kagaku Co Ltd | 易吸収性ミネラル含有飲食物 |
| JPH10279595A (ja) * | 1997-04-02 | 1998-10-20 | Taiyo Kagaku Co Ltd | 卵黄低分子ペプチド |
| JP2000106843A (ja) * | 1998-10-02 | 2000-04-18 | Q P Corp | カロチノイド系色素含有材料の退色防止剤及び退色防止方法 |
| JP2001061445A (ja) * | 1999-08-31 | 2001-03-13 | Taiyo Kagaku Co Ltd | 蛋白酵素分解物 |
| JP2005021087A (ja) * | 2003-07-03 | 2005-01-27 | Pharmafoods Kenkyusho:Kk | 卵由来の骨強化組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0453471A (ja) * | 1990-06-22 | 1992-02-21 | Snow Brand Milk Prod Co Ltd | 骨強化食品、飼料及び医薬 |
| JP2001328919A (ja) * | 2000-05-19 | 2001-11-27 | Pharmafoods Kenkyusho:Kk | 抗酸化組成物及びそれを含有する化粧料 |
| CN1451729A (zh) * | 2003-03-25 | 2003-10-29 | 江南大学 | 一种利用酶水解－溶剂萃取法提取蛋黄油脂的方法 |
-
2005
- 2005-03-28 KR KR1020050025622A patent/KR20060082015A/ko not_active Application Discontinuation
-
2006
- 2006-01-06 CN CN2006800020935A patent/CN101188949B/zh active Active
- 2006-01-06 JP JP2006552899A patent/JP5213332B2/ja active Active
- 2006-01-06 WO PCT/JP2006/300082 patent/WO2006075558A1/ja not_active Application Discontinuation
- 2006-01-06 KR KR1020077017967A patent/KR101156703B1/ko active IP Right Grant
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08256698A (ja) * | 1995-03-24 | 1996-10-08 | Taiyo Kagaku Co Ltd | 易吸収性ミネラル含有飲食物 |
| JPH10279595A (ja) * | 1997-04-02 | 1998-10-20 | Taiyo Kagaku Co Ltd | 卵黄低分子ペプチド |
| JP2000106843A (ja) * | 1998-10-02 | 2000-04-18 | Q P Corp | カロチノイド系色素含有材料の退色防止剤及び退色防止方法 |
| JP2001061445A (ja) * | 1999-08-31 | 2001-03-13 | Taiyo Kagaku Co Ltd | 蛋白酵素分解物 |
| JP2005021087A (ja) * | 2003-07-03 | 2005-01-27 | Pharmafoods Kenkyusho:Kk | 卵由来の骨強化組成物 |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011122127A1 (ja) * | 2010-03-31 | 2011-10-06 | 株式会社ファーマフーズ | 骨芽細胞増殖促進活性を有するペプチドおよびその利用 |
| JP2011211979A (ja) * | 2010-03-31 | 2011-10-27 | Pharma Foods International Co Ltd | 骨芽細胞増殖促進活性を有するペプチドおよびその利用 |
| WO2014007318A1 (ja) * | 2012-07-06 | 2014-01-09 | 株式会社ファーマフーズ | 軟骨細胞増殖促進剤 |
| US20150164973A1 (en) * | 2012-07-06 | 2015-06-18 | Pharma Foods International Co., Ltd. | Chondrocyte proliferation promoting agent |
| JPWO2014007318A1 (ja) * | 2012-07-06 | 2016-06-02 | 株式会社ファーマフーズ | 軟骨細胞増殖促進剤 |
| US10034911B2 (en) | 2012-07-06 | 2018-07-31 | Pharma Foods International Co., Ltd. | Chondrocyte proliferation promoting agent |
| KR20170045275A (ko) | 2014-10-31 | 2017-04-26 | 가부시키 가이샤 파마푸즈 | 발모 및 육모 촉진제 및 이들의 이용 |
| JPWO2016068338A1 (ja) * | 2014-10-31 | 2017-09-07 | 株式会社ファーマフーズ | 発毛及び育毛促進剤並びにそれらの利用 |
| US10154684B2 (en) | 2014-10-31 | 2018-12-18 | Pharma Foods International Co., Ltd. | Hair regrowth and growth promoter and use thereof |
| WO2018003817A1 (ja) * | 2016-06-27 | 2018-01-04 | 株式会社ファーマフーズ | 骨形成不全症等の予防及び／又は治療剤 |
| US11241475B2 (en) | 2016-06-27 | 2022-02-08 | Pharma Foods International Co., Ltd. | Preventive and/or therapeutic agent for osteogenesis imperfecta and other diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101188949A (zh) | 2008-05-28 |
| JPWO2006075558A1 (ja) | 2008-08-07 |
| KR101156703B1 (ko) | 2012-06-14 |
| KR20060082015A (ko) | 2006-07-14 |
| JP5213332B2 (ja) | 2013-06-19 |
| KR20070121639A (ko) | 2007-12-27 |
| CN101188949B (zh) | 2012-03-28 |
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