JP5213332B2 - 卵由来の骨強化組成物 - Google Patents
卵由来の骨強化組成物 Download PDFInfo
- Publication number
- JP5213332B2 JP5213332B2 JP2006552899A JP2006552899A JP5213332B2 JP 5213332 B2 JP5213332 B2 JP 5213332B2 JP 2006552899 A JP2006552899 A JP 2006552899A JP 2006552899 A JP2006552899 A JP 2006552899A JP 5213332 B2 JP5213332 B2 JP 5213332B2
- Authority
- JP
- Japan
- Prior art keywords
- egg yolk
- bone
- protein hydrolyzate
- molecular weight
- area ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000000988 bone and bone Anatomy 0.000 title claims description 34
- 238000005728 strengthening Methods 0.000 title claims description 18
- 239000000203 mixture Substances 0.000 title description 18
- 102000002322 Egg Proteins Human genes 0.000 claims description 67
- 108010000912 Egg Proteins Proteins 0.000 claims description 67
- 239000003531 protein hydrolysate Substances 0.000 claims description 40
- 210000002969 egg yolk Anatomy 0.000 claims description 28
- 235000013345 egg yolk Nutrition 0.000 claims description 28
- 235000013305 food Nutrition 0.000 claims description 15
- 150000001413 amino acids Chemical class 0.000 claims description 7
- 238000009826 distribution Methods 0.000 claims description 7
- 238000001641 gel filtration chromatography Methods 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 5
- 239000003960 organic solvent Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000005238 degreasing Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 description 15
- 230000001737 promoting effect Effects 0.000 description 14
- 210000000963 osteoblast Anatomy 0.000 description 13
- 230000035755 proliferation Effects 0.000 description 13
- 239000000843 powder Substances 0.000 description 11
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- 230000008468 bone growth Effects 0.000 description 9
- 229940088598 enzyme Drugs 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 208000001132 Osteoporosis Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 241000194108 Bacillus licheniformis Species 0.000 description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 7
- 239000011575 calcium Substances 0.000 description 7
- 229910052791 calcium Inorganic materials 0.000 description 7
- 235000013601 eggs Nutrition 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 108091005804 Peptidases Proteins 0.000 description 6
- 230000002308 calcification Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 210000002997 osteoclast Anatomy 0.000 description 6
- 230000003014 reinforcing effect Effects 0.000 description 6
- 230000012010 growth Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 208000020084 Bone disease Diseases 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 102000035195 Peptidases Human genes 0.000 description 4
- 239000004098 Tetracycline Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229960002180 tetracycline Drugs 0.000 description 4
- 229930101283 tetracycline Natural products 0.000 description 4
- 235000019364 tetracycline Nutrition 0.000 description 4
- 150000003522 tetracyclines Chemical class 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 102000004157 Hydrolases Human genes 0.000 description 3
- 108090000604 Hydrolases Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 235000013361 beverage Nutrition 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 102000005158 Subtilisins Human genes 0.000 description 2
- 108010056079 Subtilisins Proteins 0.000 description 2
- 208000035896 Twin-reversed arterial perfusion sequence Diseases 0.000 description 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 2
- 230000037180 bone health Effects 0.000 description 2
- 210000002798 bone marrow cell Anatomy 0.000 description 2
- 229940036811 bone meal Drugs 0.000 description 2
- 239000002374 bone meal Substances 0.000 description 2
- 230000004097 bone metabolism Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 235000013330 chicken meat Nutrition 0.000 description 2
- 210000001612 chondrocyte Anatomy 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000013365 molecular weight analysis method Methods 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000007065 protein hydrolysis Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 2
- 238000012453 sprague-dawley rat model Methods 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- 210000002303 tibia Anatomy 0.000 description 2
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 1
- VUDQSRFCCHQIIU-UHFFFAOYSA-N 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one Chemical compound CCCCCC(=O)C1=C(O)C(Cl)=C(OC)C(Cl)=C1O VUDQSRFCCHQIIU-UHFFFAOYSA-N 0.000 description 1
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 1
- AZKSAVLVSZKNRD-UHFFFAOYSA-M 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Chemical compound [Br-].S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 AZKSAVLVSZKNRD-UHFFFAOYSA-M 0.000 description 1
- 102000013563 Acid Phosphatase Human genes 0.000 description 1
- 108010051457 Acid Phosphatase Proteins 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 241000272517 Anseriformes Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- 101000993347 Gallus gallus Ciliary neurotrophic factor Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 101000942967 Homo sapiens Leukemia inhibitory factor Proteins 0.000 description 1
- 102100032352 Leukemia inhibitory factor Human genes 0.000 description 1
- 241000237502 Ostreidae Species 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 102000010498 Receptor Activator of Nuclear Factor-kappa B Human genes 0.000 description 1
- 108010038036 Receptor Activator of Nuclear Factor-kappa B Proteins 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- PPWHTZKZQNXVAE-UHFFFAOYSA-N Tetracaine hydrochloride Chemical compound Cl.CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 PPWHTZKZQNXVAE-UHFFFAOYSA-N 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 150000004663 bisphosphonates Chemical class 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229940037448 calcitonin preparations Drugs 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 210000000991 chicken egg Anatomy 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 230000037319 collagen production Effects 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 235000015140 cultured milk Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 210000003278 egg shell Anatomy 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000002745 epiphysis Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 235000013611 frozen food Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000009422 growth inhibiting effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000031787 nutrient reservoir activity Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000004072 osteoblast differentiation Effects 0.000 description 1
- 230000001582 osteoblastic effect Effects 0.000 description 1
- 235000020636 oyster Nutrition 0.000 description 1
- -1 pH adjusters Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
- A47J37/00—Baking; Roasting; Grilling; Frying
- A47J37/12—Deep fat fryers, e.g. for frying fish or chips
- A47J37/1276—Constructional details
- A47J37/129—Frying vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
- A47J37/00—Baking; Roasting; Grilling; Frying
- A47J37/12—Deep fat fryers, e.g. for frying fish or chips
- A47J37/1223—Deep fat fryers, e.g. for frying fish or chips with means for filtering the frying liquid
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
- A47J37/00—Baking; Roasting; Grilling; Frying
- A47J37/12—Deep fat fryers, e.g. for frying fish or chips
- A47J37/1266—Control devices, e.g. to control temperature, level or quality of the frying liquid
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
- A47J37/00—Baking; Roasting; Grilling; Frying
- A47J37/12—Deep fat fryers, e.g. for frying fish or chips
- A47J37/1271—Accessories
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
- A47J37/00—Baking; Roasting; Grilling; Frying
- A47J37/12—Deep fat fryers, e.g. for frying fish or chips
- A47J37/1276—Constructional details
- A47J37/1285—Valves or arrangements to drain used oil or food particles settled at the bottom of the frying vessel
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Animal Husbandry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006552899A JP5213332B2 (ja) | 2005-01-11 | 2006-01-06 | 卵由来の骨強化組成物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005003628 | 2005-01-11 | ||
| JP2005003628 | 2005-01-11 | ||
| PCT/JP2006/300082 WO2006075558A1 (ja) | 2005-01-11 | 2006-01-06 | 卵由来の骨強化組成物 |
| JP2006552899A JP5213332B2 (ja) | 2005-01-11 | 2006-01-06 | 卵由来の骨強化組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2006075558A1 JPWO2006075558A1 (ja) | 2008-08-07 |
| JP5213332B2 true JP5213332B2 (ja) | 2013-06-19 |
Family
ID=36677583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006552899A Active JP5213332B2 (ja) | 2005-01-11 | 2006-01-06 | 卵由来の骨強化組成物 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP5213332B2 (ko) |
| KR (2) | KR20060082015A (ko) |
| CN (1) | CN101188949B (ko) |
| WO (1) | WO2006075558A1 (ko) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090246319A1 (en) * | 2008-03-31 | 2009-10-01 | Kraft Foods Holdings, Inc. | Process And Formulation For Making An Egg Product With Increased Functionality And Flavor |
| JP2011211979A (ja) * | 2010-03-31 | 2011-10-27 | Pharma Foods International Co Ltd | 骨芽細胞増殖促進活性を有するペプチドおよびその利用 |
| CN102578360A (zh) * | 2011-01-06 | 2012-07-18 | 盐城市方圆食品有限公司 | 一种高水解低胆固醇鸡蛋蛋白质氨基酸液的制备方法 |
| WO2014007318A1 (ja) * | 2012-07-06 | 2014-01-09 | 株式会社ファーマフーズ | 軟骨細胞増殖促進剤 |
| CN103114117B (zh) * | 2013-01-24 | 2015-08-05 | 中国海洋大学 | 一种具有抗骨质疏松症作用的鱼卵糖蛋白的制备方法 |
| US10154684B2 (en) | 2014-10-31 | 2018-12-18 | Pharma Foods International Co., Ltd. | Hair regrowth and growth promoter and use thereof |
| JPWO2018003817A1 (ja) * | 2016-06-27 | 2019-05-23 | 株式会社ファーマフーズ | 骨形成不全症等の予防及び／又は治療剤 |
| CN107969649A (zh) * | 2017-11-28 | 2018-05-01 | 广州白云山汉方现代药业有限公司 | 一种补钙组合物及制备方法 |
| CN109125704A (zh) * | 2018-11-01 | 2019-01-04 | 北京市蜂业公司 | 蜂王浆牦牛骨小分子肽及其制备方法和应用 |
| KR20230131437A (ko) * | 2022-03-04 | 2023-09-13 | (주)메디언스 | 난황 단백질 유래 키 성장 및 골 밀도 증가용 조성물 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0453471A (ja) * | 1990-06-22 | 1992-02-21 | Snow Brand Milk Prod Co Ltd | 骨強化食品、飼料及び医薬 |
| JPH08256698A (ja) * | 1995-03-24 | 1996-10-08 | Taiyo Kagaku Co Ltd | 易吸収性ミネラル含有飲食物 |
| JPH10279595A (ja) * | 1997-04-02 | 1998-10-20 | Taiyo Kagaku Co Ltd | 卵黄低分子ペプチド |
| JP2000106843A (ja) * | 1998-10-02 | 2000-04-18 | Q P Corp | カロチノイド系色素含有材料の退色防止剤及び退色防止方法 |
| JP2001061445A (ja) * | 1999-08-31 | 2001-03-13 | Taiyo Kagaku Co Ltd | 蛋白酵素分解物 |
| JP2001328919A (ja) * | 2000-05-19 | 2001-11-27 | Pharmafoods Kenkyusho:Kk | 抗酸化組成物及びそれを含有する化粧料 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1451729A (zh) * | 2003-03-25 | 2003-10-29 | 江南大学 | 一种利用酶水解－溶剂萃取法提取蛋黄油脂的方法 |
| JP2005021087A (ja) * | 2003-07-03 | 2005-01-27 | Pharmafoods Kenkyusho:Kk | 卵由来の骨強化組成物 |
-
2005
- 2005-03-28 KR KR1020050025622A patent/KR20060082015A/ko not_active Application Discontinuation
-
2006
- 2006-01-06 JP JP2006552899A patent/JP5213332B2/ja active Active
- 2006-01-06 WO PCT/JP2006/300082 patent/WO2006075558A1/ja not_active Application Discontinuation
- 2006-01-06 KR KR1020077017967A patent/KR101156703B1/ko active IP Right Grant
- 2006-01-06 CN CN2006800020935A patent/CN101188949B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0453471A (ja) * | 1990-06-22 | 1992-02-21 | Snow Brand Milk Prod Co Ltd | 骨強化食品、飼料及び医薬 |
| JPH08256698A (ja) * | 1995-03-24 | 1996-10-08 | Taiyo Kagaku Co Ltd | 易吸収性ミネラル含有飲食物 |
| JPH10279595A (ja) * | 1997-04-02 | 1998-10-20 | Taiyo Kagaku Co Ltd | 卵黄低分子ペプチド |
| JP2000106843A (ja) * | 1998-10-02 | 2000-04-18 | Q P Corp | カロチノイド系色素含有材料の退色防止剤及び退色防止方法 |
| JP2001061445A (ja) * | 1999-08-31 | 2001-03-13 | Taiyo Kagaku Co Ltd | 蛋白酵素分解物 |
| JP2001328919A (ja) * | 2000-05-19 | 2001-11-27 | Pharmafoods Kenkyusho:Kk | 抗酸化組成物及びそれを含有する化粧料 |
Non-Patent Citations (2)
| Title |
|---|
| JPN6011046149; Ｂｒ． Ｊ． Ｎｕｔｒ． ｖｏｌ．８０, 1998, ｐ．４７７-８４ * |
| JPN6011046150; 日本農芸化学会２００４年度（平成１６年度）大会講演要旨集 , 20040305, ｐ．２００， ３Ａ１５ｐ１８ * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101188949A (zh) | 2008-05-28 |
| KR20070121639A (ko) | 2007-12-27 |
| CN101188949B (zh) | 2012-03-28 |
| KR20060082015A (ko) | 2006-07-14 |
| WO2006075558A1 (ja) | 2006-07-20 |
| JPWO2006075558A1 (ja) | 2008-08-07 |
| KR101156703B1 (ko) | 2012-06-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5213332B2 (ja) | 卵由来の骨強化組成物 | |
| JP2974604B2 (ja) | 塩基性タンパク質組成物、塩基性ペプチド組成物及びその利用 | |
| JP3929088B2 (ja) | 骨形成促進及び骨吸収防止剤 | |
| US20070264311A1 (en) | Cysteine Protease from Ginger (Zingiber) as a Food Improver and Anti-Inflammatory | |
| EP0791601B1 (en) | An agent promoting bone formation and inhibiting bone resorption | |
| US20190292242A1 (en) | Hydrolyzed Jellyfish Collagen Types I, II, and V and Use Thereof | |
| JP4447789B2 (ja) | 食物誘導される卵黄中の抗分泌タンパク質 | |
| JP2015070855A (ja) | 発酵乳および抗ウイルス剤の製造方法 | |
| WO2014007318A1 (ja) | 軟骨細胞増殖促進剤 | |
| JPH05176715A (ja) | 乳清由来の骨芽細胞増殖・骨強化画分及び該画分を含有する骨強化食品、飼料、薬品類 | |
| KR101418968B1 (ko) | ＣＨＰ(ｃｙｃｌｏ(Ｈｉｓ-Ｐｒｏ))를 고농도로 함유한 대두 가수분해물을 포함하는 혈당 조절용 조성물 | |
| JPH0453471A (ja) | 骨強化食品、飼料及び医薬 | |
| JP7286335B2 (ja) | 骨密度改善用食品組成物、骨密度改善剤、前駆骨芽細胞増殖用食品組成物、骨分化促進用食品組成物、骨強化用食品組成物、抗骨粗鬆症用食品組成物、前駆骨芽細胞増殖剤、骨分化促進剤、骨強化剤、抗骨粗鬆症剤、骨密度改善剤の製造方法、前駆骨芽細胞増殖剤の製造方法、骨分化促進剤の製造方法、骨強化剤の製造方法及び抗骨粗鬆症剤の製造方法 | |
| KR20050003989A (ko) | 난유래 골강화 조성물 | |
| KR101322282B1 (ko) | 젤라틴 유래 효소분해물을 함유하는 골 성장 촉진용 조성물 | |
| JP6083085B2 (ja) | アンジオテンシン変換酵素阻害剤およびその用途 | |
| WO2009064035A1 (en) | Growth-enhancing yeast hydrolysate and health food comprising the same | |
| JP6243777B2 (ja) | ヒアルロン酸合成促進剤 | |
| TWI574696B (zh) | 新穎蛋白質素材 | |
| TWI804459B (zh) | 乳過氧化酶、胱抑素、ｈｍｇ樣蛋白質及/或它們之分解物之用途 | |
| JP2024511909A (ja) | 卵黄タンパク質由来の身長成長及び骨密度増加用組成物 | |
| JP4659405B2 (ja) | 骨形成促進剤 | |
| KR20060101576A (ko) | 난황유래 골강화 조성물 분리 | |
| JP2012180368A (ja) | 骨吸収抑制剤 | |
| KR20140022232A (ko) | 젤라틴의 가수분해물을 포함하는 발효유 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090106 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20100901 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20100902 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110906 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111107 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20120517 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20120521 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120626 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120924 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130219 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130226 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5213332 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160308 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |