WO2006072196A1 - Appareil et procede therapeutiques a ultrasons focalises a haute intensite - Google Patents
Appareil et procede therapeutiques a ultrasons focalises a haute intensite Download PDFInfo
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- WO2006072196A1 WO2006072196A1 PCT/CN2005/001175 CN2005001175W WO2006072196A1 WO 2006072196 A1 WO2006072196 A1 WO 2006072196A1 CN 2005001175 W CN2005001175 W CN 2005001175W WO 2006072196 A1 WO2006072196 A1 WO 2006072196A1
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- focused ultrasound
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- 238000002604 ultrasonography Methods 0.000 title claims abstract description 48
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims description 18
- 238000012545 processing Methods 0.000 claims abstract description 28
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 16
- 230000000694 effects Effects 0.000 claims abstract description 8
- 238000009210 therapy by ultrasound Methods 0.000 claims description 12
- 238000002203 pretreatment Methods 0.000 claims description 8
- 241001270131 Agaricus moelleri Species 0.000 claims description 3
- 238000005070 sampling Methods 0.000 abstract 3
- 210000001519 tissue Anatomy 0.000 description 17
- 206010028980 Neoplasm Diseases 0.000 description 10
- 238000011287 therapeutic dose Methods 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 6
- 238000004364 calculation method Methods 0.000 description 3
- 230000001112 coagulating effect Effects 0.000 description 3
- 210000005228 liver tissue Anatomy 0.000 description 3
- 230000017074 necrotic cell death Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000012805 animal sample Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
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- 238000012806 monitoring device Methods 0.000 description 1
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- 238000010361 transduction Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
Definitions
- the present invention relates to a high intensity focused ultrasound therapy apparatus and method, and more particularly to an apparatus and method for controlling the firing and stopping of therapeutic ultrasound waves based on grayscale changes in the ultrasound image. Background technique
- the high-intensity focused ultrasound tumor treatment system is based on the characteristics of tumor cells. With ultrasound as the energy source, the penetrating and focusing ability of the probe is used to couple the ultrasonic waves with lower average sound intensity emitted by the probe through the medium.
- the B-ultrasound devices in the existing ultrasound treatment equipment are mainly used for the localization and observation of tumors before treatment, but After treatment, whether the target treatment area has reached the required therapeutic dose, whether the target tissue has formed coagulative necrosis.
- the existing equipment is based on MRI or CT examination after a period of time.
- the therapeutic effect cannot be observed in time, the therapeutic dose can only be controlled by experience. If the dose is insufficient, the diseased tissue cannot be effectively killed, and the therapeutic effect is not achieved. If necessary, it may damage the normal tissue, which has a great safety factor. Therefore, it is necessary to evaluate the therapeutic effect in real time during the treatment. Summary of the invention
- the high-intensity focused ultrasound therapy apparatus of the present invention has: an ultrasonic transducer for transmitting high-intensity focused ultrasound to a treatment target; an image acquisition device for positioning a treatment target and collecting an image of the treatment target a driving unit, coupled to the ultrasonic transducer, driving the ultrasonic transducer to emit ultrasonic waves to the therapeutic target region; and a moving mechanism coupled to the ultrasonic transducer to move the ultrasonic transducer together with the image capturing device Scanning the treatment target area
- the high-intensity focused ultrasound treatment device further comprises: a signal processing unit connected to the image collection device, receiving and storing the original image of the target area collected by the image acquisition device before the treatment, Receiving and storing the image of the target area collected by the image acquisition device at a certain moment in the process of high-intensity focused ultrasound therapy, and determining the treatment effect according to the stored pre-treatment image and the post-treatment image; and the control unit, respectively, and the
- the high-intensity focused ultrasound treatment method of the present invention includes the following steps: an original image collection step, receiving and collecting an original image of a treatment target area before treatment; a treatment step, emitting high-intensity focused ultrasound, for treating The target area is treated; the therapeutic effect judging step is to collect and store the target area image at a specific moment in the high-intensity focused ultrasound treatment process, and judge the treatment effect according to the stored pre-treatment image and the post-treatment image, when judging When the treatment request has been met, the treatment of the treatment target area is stopped, and when it is judged that the treatment requirement has not been reached, the treatment target area is treated.
- Figure 1 is a block diagram showing the structure of the present invention.
- Figure 2 is a flow chart showing the operation of the present invention.
- Figure 3 shows a B-ultrasound image of the tissue before treatment.
- Figure 4 shows a B-ultrasound image of the tissue after treatment.
- Figure 5 shows a B-ultrasound image of the tissue before treatment.
- Figure 6 shows a B-ultrasound image of the tissue after treatment.
- the high-intensity focused ultrasound therapy apparatus of the present invention has a conventional ultrasonic transducer 1, an image collecting device 2, a driving unit 6, and a moving mechanism 7. Furthermore, in order to achieve the object of the present invention, a signal processing unit 4 and a control unit 5 are also provided. Among them, the ultrasonic transducer 1 is used to emit high-intensity focused ultrasound waves to the target area.
- the image pickup device 2 is mounted on the ultrasonic transducer 1 for positioning the tumor and collecting images of the treatment target area, and an existing imaging device can be used.
- the B-mode device is taken as an example for description.
- the signal processing unit 4 is connected to the B-mode 2 for receiving and storing the image acquired by the B-mode 2, and then calculating and evaluating the gray-scale change of the current target image based on the original image data before the treatment.
- the indicator 3 is connected to the signal processing unit 4 for displaying an image output by the signal processing unit 4.
- the drive unit 6 is connected to the ultrasonic transducer 1 and, under the control of the control unit 5, drives the ultrasonic transducer 1 to emit ultrasonic waves to the treatment target area.
- the motion mechanism 7 is connected to the ultrasonic transducer 1 and, under the control of the control unit 5, causes the ultrasonic transducer 1 and the B-super device 2 to move together.
- the control unit 5 is connected to the signal processing unit 4, the driving unit 6, and the motion mechanism 7, respectively, and receives the calculation evaluation result of the grayscale change of the target image output by the signal processing unit 4, and then controls the driving unit 6 and the motion according to the calculation evaluation result.
- the B-ultrasound device 2 collects the original image of the target area and transmits the original image of the target area to the signal processing unit 4, and the signal processing unit 4 calculates the original gray of the target area image. The degree value is then stored as the basis for subsequent evaluation.
- step S2 the control unit 5 controls the driving unit 6 and the motion mechanism 7 to cause the ultrasonic transducer 1 to emit high-intensity focused ultrasound and scan the target region to target the tumor in the target region.
- the cells are treated.
- the B-ultrasound device 2 collects the target area image again and transmits the target area image to the signal processing unit 4, and the signal processing unit 4 calculates the gray value of the target image after the treatment, and then according to the stored original gray value, The grayscale change value of the target area image after treatment is calculated.
- step S4 the signal processing unit 4 determines whether the calculated grayscale change value of the target image exceeds a certain value. If the grayscale change value of the target image exceeds the specified value, it means that the ultrasonic treatment of the target region has reached the therapeutic dose, and the high intensity focused ultrasound can be stopped. Conversely, if the target image grayscale change value does not exceed the specified value, it means that the ultrasound treatment of the target region has not reached the therapeutic dose, and high intensity focused ultrasound should continue to be used for treatment.
- the inventors have conducted a large number of experiments on animal samples, and the gray-scale changes before and after the sonogram of the target area are related to the radiation intensity, the radiation time, the radiation depth, the tissue structure, the tissue function state, and the treatment mode, but The gray scale changes more than 5-10 gray scales, and coagulative necrosis occurs in the tumor tissue of the target area.
- the present invention distributes the gray values evenly over the spatial range [0 to 255], with 0 being all black and 255 being all white.
- the calculation method of the gray value and the gray scale change value is that the computer collects the image at a specific moment from the monitoring device B, such as a static image before and after the treatment.
- the computer system automatically records the position, energy, and equipment parameters when the image was acquired.
- the comparison area can be points, lines (straight lines, curves, treatment tracks, etc.), faces (rectangles, manual sketches), and so on.
- step S4 Calculate grayscale eigenvalues in the set area according to the position of the image processing trajectory before and after, such as grayscale total value, grayscale average value, grayscale weighting value (sum, average, etc.), regional center grayscale value, etc.; Compare grayscale feature values before and after, such as difference operations, convolutions, and so on. If it is determined in step S4 that the target area grayscale change value exceeds the prescribed value, the signal processing unit 4 sends a stop command to the control unit 5, and the control unit 5 controls the drive unit 6 and the motion mechanism 7 to perform ultrasonic transduction according to the stop command.
- the device 1 stops emitting high intensity focused ultrasound and scanning, ie ends the treatment.
- step S4 If it is determined in step S4 that the grayscale change value of the target image does not exceed the prescribed value, then The signal processing unit 4 transmits a continuation therapy command to the control unit 5, returning to step S2.
- the control unit 5 controls the drive unit 6 and the motion mechanism 7 in accordance with the instruction to cause the ultrasonic transducer 1 to continue to emit high-intensity focused ultrasound and scanning to continue treatment of the target zone.
- Fig. 3 and Fig. 4 are comparative B-ultrasound images of the same animal liver tissue before and after treatment
- Fig. 3 is the pre-treatment image
- Fig. 4 is the treatment image after high-intensity focused ultrasound treatment, and the focus of the target area can be clearly seen.
- the gray scale has changed. Through dissection, this part of the liver tissue has formed coagulative necrosis, which meets the requirements of treatment. This also proves that this method is effective in evaluating the efficacy.
- Figure 5 and Figure 6 are comparative B-ultrasound images of liver tissue of another animal before and after treatment
- Figure 5 is the pre-treatment image
- Figure 6 is the treatment image after high-intensity focused ultrasound treatment
- the results and phenomena and Figure 3 is the same, no longer repeat here.
- the therapeutic effect can be evaluated in real time during the treatment process, and the therapeutic dose of the high-intensity focused ultrasound can be adjusted according to the evaluation result, and the therapeutic dose can be avoided once and can not be avoided. Effectively kill tumor tissue, or treat tissues that are too large to damage normal tissues.
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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Description
高强度聚焦超声治疗装置和方法 技术领域
本发明涉及一种高强度聚焦超声治疗装置和方法， 尤其涉及根 据超声图像的灰度变化来控制治疗超声波的发射和停止的装置和方 法。 背景技术
医学研究发现肿瘤细胞的耐热性比正常细胞要差， 在 42. 5°C以 上的温度环境下， 30 分钟内肿瘤细胞死亡， 而正常细胞损伤较轻且 可逆转。 高强度聚焦超声肿瘤治疗系统就是根据肿瘤细胞的这一特 点， 以超声波为能量源， 利用其穿透性和可聚焦性， 将探头发射出的 平均声强较低的超声波通过介质耦合， 经过皮肤进入人体肿瘤组织， 聚焦或者汇聚到一个空间点， 形成一个平均声强在 lOOOW/m2以上的 焦域 （焦域大小： Φ 3 ram X 8mm ) ， 使该焦域瞬时 （0. 1 秒到 5秒） 产生强烈的温度升高 （高于 70 °C ) , 加上其空化作用 （即强超声在 液体中产生类似雾状的气泡，其形成和消失可以产生极高的温度和压 力，从而使组织受到严重破坏）和机械振荡作用，破坏焦域处的组织。 通过对肿瘤进行如此由点到线、 由线到面、 由面到体逐点扫描的固化 治疗， 从而使整个肿瘤组织固化， 实现治疗的目的。
随着超声治疗技术的发展， 超声波联合 B超装置等成像设备来 检测治疗肿瘤也取得了长足的进步，现有超声治疗设备中的 B超装置 主要用于治疗前对肿瘤的定位和观察，但是治疗后靶区是否达到了所 需的治疗剂量， 靶区组织是否形成了凝固性坏死， 对于术后的疗效评 价， 现有设备采用的方法是靠术后过一段时间进行核磁共振或 CT检 查来进行的， 这样就存在很多缺点， 由于不能及时观察治疗效果， 治 疗剂量只能凭经验控制，如果是剂量不足， 就不能有效地杀死病变组 织， 达不到治疗的效果， 而如果是剂量超过所需， 则可能损伤到正常 的组织， 这样就存在很大的安全因素。 因此治疗过程中对治疗效果进 行实时评价就非常必要。
发明内容
为了解决上述问题， 本发明的高强度聚焦超声治疗装置具有： 超声换能器，用于向治疗靶区发射高强度聚焦超声波；图像采集装置， 用来定位治疗靶区并且采集治疗靶区的图像； 驱动单元， 与上述超声 换能器连接， 驱动上述超声换能器向治疗靶区发射超声波； 以及运动 机构， 与上述超声换能器连接， 使上述超声换能器和上述图像采集装 置一同移动， 对治疗靶区进行扫描， 其特征在于， 该高强度聚焦超声 治疗装置还具有： 信号处理单元， 与图像釆集装置连接， 在治疗前接 收并存储图像采集装置采集的靶区原始图像，在高强度聚焦超声治疗 过程中的某一特定时刻， 接收并存储图像采集装置采集的靶区图像， 并根据所存储的治疗前图像和治疗后图像来判断治疗效果；以及控制 单元， 分别与信号处理单元、 驱动单元和运动机构连接， 当信号处理 单元判断已达到治疗要求时， 控制驱动单元和运动机构， 使超声换能 器停止工作， 当信号处理单元判断还没有达到治疗要求时， 控制驱动 单元和运动机构， 使超声换能器继续工作。
另外， 本发明的高强度聚焦超声治疗方法， 其特征在于， 包括 以下步骤： 原始图像釆集步骤， 在治疗前接收并采集治疗靶区的原始 图像； 治疗步骤， 发射高强度聚焦超声， 对治疗靶区进行治疗； 治疗 效果判断步骤， 在高强度聚焦超声治疗过程中的某一特定时刻， 采集 并存储靶区图像，并根据所存储的治疗前图像和治疗后图像来判断治 疗效果， 当判断已达到治疗要求时， 停止对治疗靶区的治疗， 当判断 还没有达到治疗要求时， 进行对治疗靶区进行治疗。
根据上述本发明的高强度聚焦超声治疗装置和方法， 就能够在 治疗过程中实时地对治疗靶区的治疗效果进行评价，并根据评价结果 来决定是对靶区继续进行治疗， 还是停止治疗。从而能够准确地掌握 治疗剂量， 达到最佳的治疗效果。 附图说明
图 1所示为本发明的结构框图。
图 2所示为本发明的工作流程图。
图 3所示为治疗前组织的 B超图像。
图 4所示为治疗后组织的 B超图像。
图 5所示为治疗前组织的 B超图像。
图 6所示为治疗后组织的 B超图像。 具体实施方式
以下参照图 1， 对本发明的结构进行说明。 如图 1所示， 本发明 的高强度聚焦超声治疗装置具有通常的超声换能器 1、 图像釆集装置 2、 驱动单元 6、 运动机构 7。 此外， 为了实现本发明的目的， 还设置 有信号处理单元 4和控制单元 5。 其中， 超声换能器 1用于向靶区发 射高强度聚焦超声波。 图像采集装置 2安装在超声换能器 1上， 用来 定位肿瘤并且采集治疗靶区的图像， 可以采用现有的成像设备， 在本 发明中， 以 B超装置为例进行说明。 信号处理单元 4与 B超装置 2 连接， 用来接收并存储 B超装置 2采集的图像， 然后根据治疗前原始 图像数据来计算评价当前靶区图像的灰阶变化。 示器 3与信号处理 单元 4连接， 用于显示信号处理单元 4输出的图像。驱动单元 6与超 声换能器 1连接， 在控制单元 5的控制下， 驱动超声换能器 1向治疗 靶区发射超声波。 运动机构 7 与超声换能器 1 连接， 在控制单元 5 的控制下， 使超声换能器 1和 B超装置 2—同移动。控制单元 5分别 与信号处理单元 4、 驱动单元 6和运动机构 7连接， 接收信号处理单 元 4输出的靶区图像灰阶变化的计算评价结果，然后根据该计算评价 结果来控制驱动单元 6和运动机构 7的工作。
以下参照图 2，对本发明高强度聚焦超声治疗装置的工作流程进 行说明。 如图 2所示， 在开始治疗后， 进入步骤 S l， B超装置 2采集 靶区原始图像并将靶区原始图像传送给信号处理单元 4， 信号处理单 元 4计算出靶区图像的原始灰度值， 然后存储该原始灰度值， 作为随 后计算评价的依据。
在步骤 S2中， 控制单元 5控制驱动单元 6和运动机构 7， 使超 声换能器 1发射高强度聚焦超声并对靶区进行扫描，来对靶区的肿瘤
细胞进行治疗。
在某一特定时刻， 例如进行至少一次扫描运动之后， 进入步骤
S3， B超装置 2再次采集靶区图像并将靶区图像传送给信号处理单元 4， 信号处理单元 4计算治疗后的靶区图像的灰度值， 然后根据所存 储的原始灰度值， 来计算治疗后的靶区图像的灰阶变化值。
然后进入步骤 S4， 信号处理单元 4判断所计算出的靶区图像灰 阶变化值是否超过某一规定值。 如果靶区图像灰阶变化值超过规定 值， 则意味着对靶区的超声治疗已经达到了治疗剂量， 这时可以停止 发射高强度聚焦超声。相反， 如果靶区图像灰阶变化值没有超过规定 值， 则意味着对靶区的超声治疗还没有达到治疗剂量， 应继续发射高 强度聚焦超声进行治疗。 本发明人对动物样本进行了大量的实验发 现， 靶区声像图前后灰阶变化除了与超声功率、 辐射时间有关外， 还 与辐射深度、 组织结构、 组织功能状态和治疗方式有关， 但只要灰阶 变化超过 5— 10个灰阶， 靶区的肿瘤组织就发生了凝固性坏死。本发 明将灰度值平均分布在 [0〜255]空间范围内， 0表示全黑， 255表示 全白。
灰度值和灰阶变化值的计算方法是计算机从监控设备 B超上釆 集特定时刻的图像， 如治疗前、 治疗后的静态图像。 计算机系统自动 记录采集图像时的位置、 能量及设备参数。 利用计算机图形学算法， 比如差运算、 卷积等操作， 比较指定位置的灰阶变化。 比较区域可以 是点、 线 （直线、 曲线、 治疗轨迹等） 、 面 （矩形、 手动勾画） 等等。 根据前后图像治疗轨迹的位置， 计算设定区域内的灰阶特征值， 比如 灰阶总值、 灰阶平均值、 灰阶加权值 （总和、 平均等） 、 区域中心灰 阶值等等；再将前后的灰阶特征值进行比较， 比如差运算、卷积等等。 如果在步骤 S4中判断靶区图像灰阶变化值超过规定值， 则信号 处理单元 4向控制单元 5发送停止指令， 控制单元 5根据停止指令， 控制驱动单元 6和运动机构 7， 使超声换能器 1停止发射高强度聚焦 超声和扫描， 即结束治疗。
如果在步骤 S4中判断靶区图像灰阶变化值没有超过规定值， 则
信号处理单元 4 向控制单元 5发送继续治疗指令， 返回步骤 S2。 在 步骤 S2中， 控制单元 5根据该指令， 控制驱动单元 6和运动机构 7， 使超声换能器 1继续发射高强度聚焦超声和扫描，对靶区继续进行治 疗。
图 3和图 4为同一个动物肝脏组织在治疗前后的对比 B超图像， 图 3为治疗前图像， 图 4为经过高强度聚焦超声治疗后的治疗图像， 可明显看出靶区的焦点处的灰度产生了变化，通过解剖， 这部分肝脏 组织形成了凝固性坏死， 达到了治疗的要求。这也证明了此方法对疗 效进行评价是行之有效的。
图 5和图 6为另一个动物肝脏组织在治疗前后的对比 B超图像， 图 5为治疗前图像， 图 6为经过高强度聚焦超声治疗后的治疗图像， 此结果和现象与图 3、 图 4相同， 这里就不再赘述。
综上所述， 通过计算靶区图像灰阶变化值， 可以在治疗过程中 实时地对治疗效果进行评价，并根据评价结果来调整高强度聚焦超声 的治疗剂量， 一次可以避免治疗剂量不足而不能有效地杀死肿瘤组 织， 或者治疗剂量过大而损伤到正常的组织。
以上所述仅为本发明具体实施例， 并非用以限定本发明的保护 范围， 凡其它未脱离本发明所揭示的精神下所完成的等效改变或变 形， 均应包含在所述的专利申请的范围内。
Claims
1. 一种高强度聚焦超声治疗装置， 具有： 超声换能器， 用于向 治疗靶区发射高强度聚焦超声波； 图像采集装置， 用来定位治疗靶区 并且采集治疗靶区的图像； 驱动单元， 与上述超声换能器连接， 驱动 上述超声换能器向治疗靶区发射超声波； 以及运动机构， 与上述超声 换能器连接， 使上述超声换能器和上述图像采集装置一同移动， 对治 疗靶区进行扫描， 其特权征在于，
该高强度聚焦超声治疗装置还具有：
信号处理单元， 与图像采集装置连接， 在治疗前接收并存储图 像釆集装置采集的靶区原始图像，在高强度聚焦超声治疗过程中的某 一特定时刻， 接收并存储图像采集装置采集的靶区图像， 并根据所存 储的治疗前图像和治疗后图像来判断治疗书效果； 以及
控制单元， 分别与信号处理单元、 驱动单元和运动机构连接， 当信号处理单元判断已达到治疗要求时， 控制驱动单元和运动机构， 使超声换能器停止工作， 当信号处理单元判断还没有达到治疗要求 时， 控制驱动单元和运动机构， 使超声换能器继续工作。
2. 根据权利要求 1所述的高强度聚焦超声治疗装置， 其特征在 于，上述信号处理单元分别计算上述治疗前图像和治疗后图像的灰度 值， 进而计算治疗前后的靶区图像灰阶变化值， 当治疗前后的灰阶变 化值超过某一规定值时， 则判断已达到治疗要求， 当灰阶变化值没有 超过上述规定值时， 则判断还没有达到治疗要求。
3. 根据权利要求 2所述的高强度聚焦超声治疗装置， 其特征在 于， 上述灰阶变化值的规定值为 5个灰阶。
4. 根据权利要求 1至 3任意一项所述的高强度聚焦超声治疗装 置， 其特征在于，上述特定时刻指超声换能器对治疗靶区进行至少一 次扫描运动之后的时刻。
5. 一种高强度聚焦超声治疗方法， 其特征在于， 包括以下步骤： 原始图像采集步骤， 在治疗前接收并采集治疗靶区的原始图像； 治疗步骤， 发射高强度聚焦超声， 对治疗靶区进行治疗； 治疗效果判断步骤， 在高强度聚焦超声治疗过程中的某一特定 时刻， 采集并存储靶区图像， 并根据所存储的治疗前图像和治疗后图 像来判断治疗效果， 当判断已达到治疗要求时， 停止对治疗靶区的治 疗， 当判断还没有达到治疗要求时， 进行对治疗靶区进行治疗。
6. 根据权利要求 5所述的高强度聚焦超声治疗方法， 其特征在 于，
在上述治疗效果判断步骤中， 分别计算上述治疗前图像和治疗 后图像的灰度值，进而计算治疗前后的靶区图像灰阶变化值， 当治疗 前后的灰阶变化值超过某一规定值时， 则判断已达到治疗要求， 当灰 阶变化值没有超过上述规定值时， 则判断还没有达到治疗要求。
7. 根据权利要求 6所述的高强度聚焦超声治疗方法， 其特征在 于， 上述灰阶变化值的规定值为 5个灰阶。
8. 根据权利要求 5至 7任意一项所述的高强度聚焦超声治疗方 法， 其特征在于， 上述特定时刻指对治疗靶区进行至少一次扫描运动 之后的时刻。
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| JP2007549778A JP4833997B2 (ja) | 2005-01-10 | 2005-08-02 | 高強度集束超音波療法のための方法および装置 |
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| KR102645074B1 (ko) | 2023-08-09 | 2024-03-08 | (주)웨버인스트루먼트 | 4세대형 선형포커스방식의 고강도 집속형 초음파 시스템 |
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| CN2551208Y (zh) * | 2002-05-10 | 2003-05-21 | 绵阳索尼克电子有限责任公司 | 肿瘤治疗超声聚焦刀 |
| US20030153961A1 (en) * | 2000-12-22 | 2003-08-14 | Eilaz Babaev | Wound treatment method and device with combination of ultrasound and laser energy |
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| DE19506363A1 (de) * | 1995-02-24 | 1996-08-29 | Frost Lore Geb Haupt | Verfahren zur nicht-invasiven Thermometrie in Organen unter medizinischen Hyperthermie- und Koagulationsbedingungen |
| US6154560A (en) * | 1996-08-30 | 2000-11-28 | The Cleveland Clinic Foundation | System and method for staging regional lymph nodes using quantitative analysis of endoscopic ultrasound images |
| CN1058905C (zh) * | 1998-01-25 | 2000-11-29 | 重庆海扶(Hifu)技术有限公司 | 高强度聚焦超声肿瘤扫描治疗系统 |
| US6540700B1 (en) * | 1998-10-26 | 2003-04-01 | Kabushiki Kaisha Toshiba | Ultrasound treatment apparatus |
| JP2000229098A (ja) * | 1998-12-09 | 2000-08-22 | Toshiba Corp | 超音波治療装置 |
| US6157854A (en) * | 1999-01-13 | 2000-12-05 | Bales Scientific Inc. | Photon irradiation human pain treatment monitored by thermal imaging |
| US7510536B2 (en) * | 1999-09-17 | 2009-03-31 | University Of Washington | Ultrasound guided high intensity focused ultrasound treatment of nerves |
| JP4380863B2 (ja) * | 1999-12-14 | 2009-12-09 | 株式会社東芝 | 超音波治療装置 |
| AU2001255724A1 (en) * | 2000-04-29 | 2001-11-12 | Focus Surgery, Inc. | Non-invasive tissue characterization |
| US7054474B1 (en) * | 2001-07-25 | 2006-05-30 | 3D Sharp, Inc. | Image noise reduction |
| NL1025780C2 (nl) * | 2004-03-22 | 2005-09-26 | Smart Medical Solutions B V | Katheter en werkwijze voor gebruik van een dergelijke katheter voor het verwijderen van een stenose uit een vat. |
| KR20070015883A (ko) * | 2005-08-01 | 2007-02-06 | 바이오센스 웹스터 인코포레이티드 | 경피 판막 성형술의 모니터링 |
| KR100868483B1 (ko) * | 2005-10-07 | 2008-11-12 | 주식회사 메디슨 | 초음파영상 디스플레이 방법 |
-
2005
- 2005-01-10 CN CNB2005100003513A patent/CN100542635C/zh active Active
- 2005-08-02 EP EP05771731A patent/EP1837051B1/en active Active
- 2005-08-02 KR KR1020077015736A patent/KR100895358B1/ko active IP Right Grant
- 2005-08-02 JP JP2007549778A patent/JP4833997B2/ja active Active
- 2005-08-02 WO PCT/CN2005/001175 patent/WO2006072196A1/zh active Application Filing
- 2005-08-02 ES ES05771731T patent/ES2396362T3/es active Active
- 2005-08-02 BR BRPI0518496-7A patent/BRPI0518496A2/pt not_active IP Right Cessation
- 2005-08-02 CA CA002591270A patent/CA2591270C/en active Active
- 2005-08-02 RU RU2007126074/14A patent/RU2359721C2/ru active
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030153961A1 (en) * | 2000-12-22 | 2003-08-14 | Eilaz Babaev | Wound treatment method and device with combination of ultrasound and laser energy |
| CN2551208Y (zh) * | 2002-05-10 | 2003-05-21 | 绵阳索尼克电子有限责任公司 | 肿瘤治疗超声聚焦刀 |
Non-Patent Citations (1)
| Title |
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| See also references of EP1837051A4 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008526326A (ja) | 2008-07-24 |
| RU2359721C2 (ru) | 2009-06-27 |
| EP1837051B1 (en) | 2012-06-13 |
| EP1837051A1 (en) | 2007-09-26 |
| US20080188745A1 (en) | 2008-08-07 |
| AU2005324269A1 (en) | 2006-07-13 |
| CA2591270A1 (en) | 2006-07-13 |
| RU2007126074A (ru) | 2009-02-20 |
| CN1803224A (zh) | 2006-07-19 |
| KR20070098856A (ko) | 2007-10-05 |
| KR100895358B1 (ko) | 2009-04-29 |
| CN100542635C (zh) | 2009-09-23 |
| ES2396362T3 (es) | 2013-02-21 |
| BRPI0518496A2 (pt) | 2008-11-25 |
| EP1837051A4 (en) | 2009-09-09 |
| CA2591270C (en) | 2009-09-01 |
| AU2005324269B2 (en) | 2009-09-10 |
| JP4833997B2 (ja) | 2011-12-07 |
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