WO2022224454A1 - 光治療装置、光治療方法および光治療プログラム - Google Patents
光治療装置、光治療方法および光治療プログラム Download PDFInfo
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Definitions
- the present invention relates to a phototherapy device, a phototherapy method, and a phototherapy program.
- photoimmunotherapy is used to treat cancer by specifically binding antibody drugs to the proteins of cancer cells and activating the antibody drugs by irradiation with near-infrared light, which is therapeutic light, to destroy cancer cells.
- Photoimmunotherapy (PIT) research is in progress (see, for example, Patent Document 1).
- the antibody drug irradiated with near-infrared light absorbs light energy, causes molecular vibration, and generates heat. This heat destroys cancer cells.
- the antibody drug emits fluorescence when excited. The intensity of this fluorescence is used as an index of therapeutic efficacy.
- the therapeutic effect is considered to have the following three effects. 1. 1. direct destructive effect on cancer cells; 3. Indirect injury caused by changes in blood flow; Indirect Damage Caused by Immune Activation It is also known that when cancer expands, capillaries increase and the mucosal surface becomes intricately patterned. Due to the indirect injury caused by the change in blood flow described in 2 above, the capillaries on the surface of the mucous membrane and the micropattern of the mucous membrane change around the therapeutic light irradiation site. Therefore, changes in capillaries on the mucosal surface and changes in mucosal micropatterns are important indicators for confirming therapeutic effects.
- Patent Document 1 evaluates the therapeutic effect based on the amount of decrease in fluorescence, it may not be possible to appropriately evaluate the therapeutic effect.
- fluorescent reagents attenuate their light intensity over time, so it is difficult to determine whether the attenuation of light intensity is due to the treatment or to changes in the drug over time.
- the present invention has been made in view of the above, and aims to provide a phototherapy device, a phototherapy method, and a phototherapy program that can appropriately confirm the therapeutic effect.
- the phototherapy device includes a therapeutic light emitting unit that emits therapeutic light that causes a drug to react, and light in a part of the visible light range.
- a narrowband light emitting unit that emits narrowband light
- a narrowband light image acquiring unit that acquires a narrowband light image obtained by the narrowband light irradiated to the irradiation position of the therapeutic light, and irradiation of the therapeutic light
- a narrow-band light image change calculator that calculates a temporal change in the narrow-band light images before and after; and a display image generator that generates a display image including information based on the change in the narrow-band light images.
- the narrowband light consists of a wavelength band of 390 nm or more and 445 nm or less and a wavelength band of 530 nm or more and 550 nm or less
- the narrow band light image change calculation unit A blood vessel structure is extracted from the narrow-band light image, and a temporal change in contrast of the extracted blood vessel structure is calculated.
- the narrowband light consists of a wavelength band of 390 nm or more and 445 nm or less and a wavelength band of 530 nm or more and 550 nm or less
- the narrow band light image change calculation unit The structure of the mucosal surface is extracted from the narrow-band light image, and the temporal change in clarity of the extracted structure of the mucosal surface is calculated.
- the narrowband light consists of a wavelength band of 390 nm or more and 445 nm or less and a wavelength band of 530 nm or more and 550 nm or less
- the narrow band light image change calculation unit The structure of the mucosal surface is extracted from the narrow-band light image, and the temporal change in uniformity of the structure of the extracted mucosal surface is calculated.
- the phototherapy apparatus further comprises a control unit that controls emission of the therapeutic light and the narrowband light at different timings and at timings that do not overlap each other.
- the narrowband light image change calculation unit divides the narrowband light image into a plurality of regions, and calculates the amount of change in the image in each of the divided regions. calculate.
- the display image generation unit arranges a narrowband light image before irradiation with the therapeutic light and a narrowband light image after irradiation with the therapeutic light. Generate a display image.
- the display image generation unit superimposes a narrowband light image before irradiation with the therapeutic light and a narrowband light image after irradiation with the therapeutic light. Generate a display image.
- the phototherapy apparatus further includes an estimation unit that estimates the output of the therapeutic light based on the change in the image calculated by the narrow-band light image change calculation unit.
- the phototherapy apparatus further includes an estimation unit that estimates the irradiation time of the therapeutic light based on the change in the image calculated by the narrow-band light image change calculation unit.
- the phototherapy method according to the present invention is a phototherapy method for confirming the therapeutic effect by irradiating a treatment site with therapeutic light that causes a drug to react
- the treatment site before irradiation with the therapeutic light is a first narrow-band light image acquisition step of acquiring a first narrow-band light image obtained by irradiating narrow-band light composed of light in a wavelength band of a part of the visible light range; a second narrowband light image acquiring step of acquiring a second narrowband light image obtained by irradiating the treatment site with the narrowband light; and a temporal change of the first and second narrowband light images.
- a display image generating step of generating a display image including information based on the change in the narrowband light image.
- the phototherapy program according to the present invention provides a phototherapy device that generates information for confirming the therapeutic effect by irradiating a therapeutic light to a treatment site with therapeutic light that causes a drug to react.
- a narrowband light image change calculating step of calculating a change and a display image generating step of generating a display image including information based on the change in the narrowband light image are executed.
- FIG. 1 is a diagram showing a schematic configuration of an endoscope system according to Embodiment 1 of the present invention.
- FIG. 2 is a block diagram showing a schematic configuration of the endoscope system according to Embodiment 1 of the present invention.
- FIG. 3 is a diagram for explaining the configuration of the distal end of the endoscope according to the first embodiment of the present invention;
- FIG. 4 is a diagram for explaining an example of the wavelength band of light used as narrowband light.
- FIG. 7 is a diagram illustrating tissue in a normal state.
- FIG. 1 is a diagram showing a schematic configuration of an endoscope system according to Embodiment 1 of the present invention.
- FIG. 2 is a block diagram showing a schematic configuration of the endoscope system according to
- FIG. 8A is a diagram (part 1) explaining a tissue containing cancer cells.
- FIG. 8B is a diagram (part 2) explaining a tissue containing cancer cells.
- FIG. 8C is a diagram (part 3) explaining a tissue containing cancer cells.
- FIG. 9 is a diagram for explaining the state of tissue before and after treatment.
- FIG. 10A is a diagram (Part 1) in which the structure is extracted for the state of tissue before and after treatment.
- FIG. 10B is a diagram (No. 2) in which the structure is extracted with respect to the state of the tissue before and after treatment.
- FIG. 11 is a diagram (No. 1) showing an example of a display screen in which images showing tissue states before and after treatment are displayed side by side.
- FIG. 12 is a diagram (part 2) showing an example of a display screen in which images showing tissue states before and after treatment are superimposed and displayed.
- FIG. 13 is a diagram for explaining treatment effect determination processing according to the second embodiment of the present invention.
- FIG. 14 is a block diagram showing a schematic configuration of an endoscope system according to Embodiment 3 of the present invention.
- FIG. 15A is a diagram (part 1) for explaining estimation processing according to the fourth embodiment of the present invention.
- FIG. 15B is a diagram (part 2) for explaining estimation processing according to the fourth embodiment of the present invention.
- FIG. 16A is a diagram (part 1) for explaining estimation processing according to the fifth embodiment of the present invention.
- FIG. 16B is a diagram (part 2) for explaining estimation processing according to the fifth embodiment of the present invention.
- FIG. 17 is a block diagram showing a schematic configuration of an endoscope system according to Embodiment 6 of the present invention.
- FIG. 1 is a diagram showing a schematic configuration of an endoscope system according to Embodiment 1 of the present invention.
- FIG. 2 is a block diagram showing a schematic configuration of the endoscope system according to the first embodiment.
- FIG. 3 is a diagram for explaining the configuration of the distal end of the endoscope according to the first embodiment.
- An endoscope system 1 shown in FIGS. 1 and 2 includes an endoscope 2 that captures an in-vivo image of a subject by inserting its distal end into the subject, and illumination light emitted from the distal end of the endoscope 2.
- a light source device 3 that generates a signal
- a processing device 4 that performs predetermined signal processing on an imaging signal captured by the endoscope 2 and controls the overall operation of the endoscope system 1, and a signal from the processing device 4
- a display device 5 for displaying an in-vivo image generated by processing and a treatment instrument device 6 are provided.
- the endoscope 2 includes an insertion section 21 having a flexible and elongated shape, an operation section 22 connected to the proximal end side of the insertion section 21 and receiving input of various operation signals, and an operation section 22 to the insertion section. and a universal cord 23 extending in a direction different from the direction in which 21 extends and containing various cables connected to the light source device 3 and the processing device 4 .
- the insertion section 21 is a flexible bendable body composed of a distal end section 24 containing an imaging device 244 in which pixels for generating signals by receiving and photoelectrically converting light are arranged two-dimensionally, and a plurality of bending pieces. It has a bending portion 25 and an elongated flexible tubular portion 26 connected to the base end side of the bending portion 25 and having flexibility.
- the insertion section 21 is inserted into the body cavity of the subject, and the imaging element 244 captures an image of a subject such as living tissue at a position where external light cannot reach.
- the operation unit 22 includes a bending knob 221 for bending the bending portion 25 in the vertical direction and the horizontal direction, and a treatment for inserting treatment tools such as a therapeutic light irradiation device, a biopsy forceps, an electric scalpel, and an examination probe into the body cavity of the subject. It has an instrument inserting portion 222 and a plurality of switches 223 as an operation input portion for inputting operation instruction signals for peripheral devices such as air supply means, water supply means, and screen display control in addition to the processing device 4 .
- a treatment instrument inserted from the treatment instrument insertion portion 222 is exposed from the opening via a treatment instrument channel (not shown) of the distal end portion 24 (see FIG. 3).
- the universal cord 23 incorporates at least a light guide 241 and a collective cable 245 that collects one or more signal lines.
- the universal cord 23 is branched at the end opposite to the side connected to the operating portion 22 .
- a connector 231 detachable from the light source device 3 and a connector 232 detachable from the processing device 4 are provided at the branch ends of the universal cord 23 .
- a part of the light guide 241 extends from the end of the connector 231 .
- the universal cord 23 propagates the illumination light emitted from the light source device 3 to the distal end portion 24 via the connector 231 (light guide 241 ), the operating portion 22 and the flexible tube portion 26 .
- the universal cord 23 transmits an image signal captured by the imaging device 244 provided at the distal end portion 24 to the processing device 4 via the connector 232 .
- the assembly cable 245 includes signal lines for transmitting imaging signals, signal lines for transmitting drive signals for driving the imaging element 244, and information including unique information about the endoscope 2 (imaging element 244). including signal lines for sending and receiving
- an electric signal is transmitted using a signal line. It may transmit a signal between them.
- the distal end portion 24 includes a light guide 241 made of glass fiber or the like and forming a light guide path for light emitted by the light source device 3, an illumination lens 242 provided at the distal end of the light guide 241, and an optical system for condensing light. It has a system 243 and an imaging element 244 which is provided at an image forming position of the optical system 243 and receives light condensed by the optical system 243, photoelectrically converts the light into an electric signal, and performs predetermined signal processing.
- the optical system 243 is configured using one or more lenses.
- the optical system 243 forms an observation image on the light receiving surface of the imaging device 244 .
- the optical system 243 may have an optical zoom function that changes the angle of view and a focus function that changes the focus.
- the imaging element 244 photoelectrically converts the light from the optical system 243 to generate an electric signal (image signal).
- the imaging element 244 is formed by arranging a plurality of pixels in a matrix, each having a photodiode that accumulates electric charge according to the amount of light and a capacitor that converts the electric charge transferred from the photodiode into a voltage level.
- the imaging element 244 photoelectrically converts light incident on each pixel through the optical system 243 to generate an electric signal, and sequentially reads out the electric signals generated by the pixels arbitrarily set as readout targets among the plurality of pixels. , are output as image signals.
- the imaging element 244 is implemented using, for example, a CCD (Charge Coupled Device) image sensor or a CMOS (Complementary Metal Oxide Semiconductor) image sensor.
- the endoscope 2 has a memory (not shown) that stores an execution program and a control program for the imaging element 244 to perform various operations, and data including identification information of the endoscope 2 .
- the identification information includes unique information (ID) of the endoscope 2, model year, spec information, transmission method, and the like.
- the memory may also temporarily store image data and the like generated by the imaging device 244 .
- the configuration of the light source device 3 will be described.
- the light source device 3 includes a light source section 31 , an illumination control section 32 and a light source driver 33 . Under the control of the illumination control unit 32, the light source unit 31 sequentially switches and emits illumination light to a subject (subject).
- the light source unit 31 is configured using a light source, one or more lenses, etc., and emits light (illumination light) by driving the light source.
- the light generated by the light source section 31 is emitted from the tip of the tip section 24 toward the subject via the light guide 241 .
- the light source section 31 has a white light source 311 and a narrow band light source 312 .
- Each light source unit, light guide 241 and illumination lens 242 constitute an emission unit.
- the narrow band light source 312, the light guide 241 and the illumination lens 242 constitute a narrow band light emitting section.
- the white light source 311 emits light (white light) having a wavelength band in the visible light range.
- the white light source 311 is implemented using any light source such as an LED light source, a laser light source, a xenon lamp, or a halogen lamp.
- the narrow-band light source 312 emits light (narrow-band light) having a partial wavelength or a wavelength band in the visible light range.
- FIG. 4 is a diagram for explaining an example of the wavelength band of light used as narrowband light.
- the narrow-band light is, for example, light L B in a wavelength band of 390 nm or more and 445 nm or less, or light L G in a wavelength band of 530 nm or more and 550 nm or less, or a combination thereof.
- Narrowband light includes, for example, light composed of light LB and light LG used for NBI (Narrow Band Imaging) observation. In this embodiment, an example of using light composed of light L B and light L G as narrow-band light will be described.
- the narrow band light source 312 is implemented using an LED light source, a laser light source, or the like.
- near-infrared light with a center wavelength of 690 nm (for example, light L P in the wavelength band of 660 nm or more and 710 nm or less shown in FIG. 4) is used.
- the blood vessels on the mucosal surface layer can be visualized with high contrast.
- the surface layer of the mucous membrane can be relatively Deep blood vessels can be visualized with high contrast.
- the lighting control unit 32 controls the amount of power supplied to the light source unit 31 based on the control signal (light control signal) from the processing device 4, and also controls the light source to emit light and the driving timing of the light source.
- the light source driver 33 supplies current to the light source to emit light, thereby causing the light source unit 31 to emit light.
- the processing device 4 includes an image processing section 41 , a synchronization signal generation section 42 , an input section 43 , a control section 44 and a storage section 45 .
- the image processing unit 41 receives image data of illumination light of each color imaged by the imaging element 244 from the endoscope 2 .
- the image processing unit 41 performs A/D conversion to generate a digital imaging signal.
- image data is received as an optical signal from the endoscope 2, the image processing unit 41 performs photoelectric conversion to generate digital image data.
- the image processing unit 41 performs predetermined image processing on the image data received from the endoscope 2 to generate an image and outputs the image to the display device 5, or sets an enhancement region determined based on the image. , and to calculate changes in fluorescence intensity over time.
- the image processor 41 has a white light image generator 411 , a narrowband light image generator 412 , a narrowband light image change calculator 413 , and a display image generator 414 .
- the white light image generation unit 411 generates a white light image based on an image formed by white light.
- the narrowband light image generator 412 generates a narrowband light image based on the image formed by the narrowband light.
- the optical system 243, the imaging element 244, and the image generation section constitute an image acquisition section.
- the optical system 243, the imaging device 244, and the narrow-band light image generation unit 412 constitute a narrow-band light image acquisition unit.
- the narrowband light image change calculation unit 413 calculates temporal changes in the narrowband light images generated by the narrowband light image generation unit 412 and captured at different times.
- the narrowband light image change calculator 413 calculates the amount of change in the subject in the image.
- a display image generation unit 414 generates an image to be displayed on the display device 5 .
- the images include images based on white light, narrowband light, and images showing changes in narrowband light images.
- the white light image generation unit 411, the narrowband light image generation unit 412, and the display image generation unit 414 generate images by performing predetermined image processing.
- the predetermined image processing includes synchronization processing, gradation correction processing, color correction processing, and the like.
- Synchronization processing is processing for synchronizing image data of each color component of RGB.
- Gradation correction processing is processing for correcting the gradation of image data.
- Color correction processing is processing for performing color tone correction on image data.
- the white light image generation unit 411, the narrowband light image generation unit 412, and the display image generation unit 414 may perform gain adjustment according to the brightness of the image.
- the image processing unit 41 is configured using a general-purpose processor such as a CPU (Central Processing Unit) or a dedicated processor such as various arithmetic circuits that execute specific functions such as an ASIC (Application Specific Integrated Circuit). Note that the image processing unit 41 may be configured to have a frame memory that holds the R image data, the G image data and the B image data.
- a general-purpose processor such as a CPU (Central Processing Unit) or a dedicated processor such as various arithmetic circuits that execute specific functions such as an ASIC (Application Specific Integrated Circuit).
- the image processing unit 41 may be configured to have a frame memory that holds the R image data, the G image data and the B image data.
- the synchronization signal generation unit 42 generates a clock signal (synchronization signal) that serves as a reference for the operation of the processing device 4, and transmits the generated synchronization signal to the light source device 3, the image processing unit 41, the control unit 44, and the endoscope 2.
- the synchronizing signal generated by the synchronizing signal generator 42 includes a horizontal synchronizing signal and a vertical synchronizing signal. Therefore, the light source device 3, the image processing section 41, the control section 44, and the endoscope 2 operate in synchronization with each other by the generated synchronization signal.
- the input unit 43 is implemented using a keyboard, a mouse, a switch, and a touch panel, and receives inputs of various signals such as operation instruction signals for instructing the operation of the endoscope system 1 .
- the input unit 43 may include a switch provided in the operation unit 22 or a portable terminal such as an external tablet computer.
- the control unit 44 performs drive control of each component including the imaging element 244 and the light source device 3, input/output control of information to each component, and the like.
- the control unit 44 refers to control information data (for example, readout timing) for imaging control stored in the storage unit 45, and performs imaging as a drive signal via a predetermined signal line included in the collective cable 245. It is transmitted to the element 244 and switches between a normal observation mode in which an image obtained by illumination with white light is observed and a narrow-band light observation mode in which an image obtained by illumination with narrow-band light is observed.
- the control unit 44 is configured using a general-purpose processor such as a CPU or a dedicated processor such as various arithmetic circuits that execute specific functions such as an ASIC.
- the storage unit 45 stores data including various programs for operating the endoscope system 1 and various parameters necessary for operating the endoscope system 1 .
- the storage unit 45 also stores identification information of the processing device 4 .
- the identification information includes unique information (ID) of the processing device 4, model year, specification information, and the like.
- the storage unit 45 also stores various programs including an image acquisition processing program for executing the image acquisition processing method of the processing device 4 .
- Various programs can be recorded on computer-readable recording media such as hard disks, flash memories, CD-ROMs, DVD-ROMs, flexible disks, etc., and can be widely distributed.
- the various programs described above can also be obtained by downloading via a communication network.
- the communication network here is realized by, for example, an existing public line network, LAN (Local Area Network), WAN (Wide Area Network), etc., and it does not matter whether it is wired or wireless.
- the storage unit 45 having the above configuration is implemented using a ROM (Read Only Memory) in which various programs etc. are pre-installed, and a RAM, hard disk, etc. for storing calculation parameters, data, etc. for each process.
- ROM Read Only Memory
- the display device 5 displays a display image corresponding to the image signal received from the processing device 4 (image processing unit 41) via the video cable.
- the display device 5 is configured using a monitor such as liquid crystal or organic EL (Electro Luminescence).
- the treatment instrument device 6 has a treatment instrument operation section 61 and a flexible treatment instrument 62 extending from the treatment instrument operation section 61 .
- the treatment instrument 62 used for PIT emits light for treatment (hereinafter referred to as treatment light).
- the treatment instrument operation section 61 controls emission of therapeutic light from the treatment instrument 62 .
- the treatment instrument operation section 61 has an operation input section 611 .
- the operation input unit 611 is composed of, for example, switches.
- the treatment instrument operating section 61 causes the treatment instrument 62 to emit therapeutic light in response to an input to the operation input section 611 (for example, pressing a switch).
- the light source that emits the therapeutic light may be provided in the treatment instrument 62 or may be provided in the treatment instrument operation section 61 .
- a light source is implemented using a semiconductor laser, an LED, or the like.
- therapeutic light is light in a wavelength band of 680 nm or more, for example, light with a central wavelength of 690 nm (for example, light L P shown in FIG. 4).
- the illumination optical system provided in the treatment instrument 62 may be configured to change the irradiation range of the treatment light.
- the treatment instrument operation unit 61 it is composed of an optical system capable of changing the focal length, a DMD (Digital Micromirror Device), etc., and changes the spot diameter of the light irradiated to the subject and the shape of the irradiation range. can do.
- FIG. 5 is a diagram showing an example of the flow of treatment using the endoscope according to the first embodiment of the present invention
- FIG. 5 is a diagram showing an example of implementation of PIT, in which treatment is performed by inserting the insertion portion 21 into the stomach ST.
- the operator inserts the insertion portion 21 into the stomach ST (see (a) in FIG. 5).
- the operator causes the light source device 3 to irradiate white light, and searches for the treatment position while observing the white light image inside the stomach ST displayed by the display device 5 .
- tumors B 1 and B 2 are to be treated as targets of treatment.
- the antibody drug is administered to the tumors B 1 and B 2 that are the sites to be treated. Administration of the antibody drug may be performed using the endoscope 2, may be performed using other equipment, or may be performed by having the patient swallow the drug.
- the operator observes the white light image and determines the regions containing the tumors B 1 and B 2 as irradiation regions. In addition, if necessary, the irradiation area is irradiated with narrow-band light to obtain a narrow-band light image.
- the operator directs the distal end portion 24 toward the tumor B1, protrudes the treatment tool 62 from the distal end of the endoscope 2 , and irradiates the tumor B1 with therapeutic light (see (b) of FIG. 5). Irradiation of the therapeutic light causes the antibody drug bound to the tumor B1 to react, and the tumor B1 is treated.
- the operator directs the distal end portion 24 toward the tumor B2, protrudes the treatment tool 62 from the distal end of the endoscope 2 , and irradiates the tumor B2 with therapeutic light (see (c) of FIG . 5). Irradiation of the therapeutic light causes the antibody drug bound to the tumor B2 to react, and the tumor B2 is treated.
- the operator directs the distal end portion 24 toward the tumor B 1 and irradiates the tumor B 1 with narrow-band light from the distal end of the endoscope 2 (see FIG. 5(d)).
- the operator confirms the therapeutic effect on tumor B 1 by acquiring post-treatment narrow-band light images. Confirmation of the therapeutic effect is determined by the operator based on changes in the image, which will be described later.
- the operator directs the distal end portion 24 toward the tumor B 2 and irradiates the tumor B 2 with narrow band light from the distal end of the endoscope 2 (see FIG. 5(e)).
- the operator confirms the therapeutic effect on Tumor B2 by acquiring post - treatment narrow-band light images.
- the operator repeats additional irradiation of therapeutic light and confirmation of therapeutic effects as necessary.
- FIG. 6 is a flowchart illustrating an example of processing of the processing apparatus according to the first embodiment
- narrow-band light is irradiated from the distal end portion 24 to the treatment position, and a narrow-band light image (first narrow-band light image) before treatment is acquired (step S101: narrow-band light image acquisition step).
- the control unit 44 causes the light source device 3 to emit narrow-band light and causes the endoscope 2 to capture an image of the narrow-band light.
- the narrowband optical image generator 412 After imaging, the narrowband optical image generator 412 generates a narrowband optical image.
- step S102 drug reaction step.
- a treatment that destroys cancer cells by activating the antibody drug by irradiation with near-infrared light, which is therapeutic light, is performed.
- step S103 narrow-band light image acquisition step.
- the control unit 44 causes the light source device 3 to emit narrowband light and causes the endoscope 2 to capture an image of the narrowband light in the same manner as in step S101.
- steps S101 and S102 or steps S102 and S103 may be performed at the same time.
- the narrowband light image change calculation unit 413 calculates changes in the narrowband light images before and after the treatment (step S104: narrowband light image change calculation step).
- the narrow-band light image change calculator 413 compares the images to calculate, as image changes, values indicating clarity and uniformity of surface tissue patterns, uniformity of blood vessel thickness, visibility, and the like.
- FIG. 7 is a diagram illustrating tissue in a normal state.
- the microstructure O S is uniformly structureless throughout and the microvessels (illustrated in dashed lines as microvessels M V in FIG. 7) are invisible.
- FIGS. 8A to 8C are diagrams illustrating tissues containing cancer cells.
- the tissue containing cancer cells differs from the normal state shown in FIG. 7 in the surface pattern of the fine structure OS and the state of blood vessels.
- a blood vessel B V surrounds each microstructure (see FIG. 8A)
- a blood vessel B V surrounds each microstructure. It may have a mesh-like blood vessel pattern (see FIG. 8B), or the microstructure pattern may be unclear and the thickness of the blood vessel B V may be uneven (see FIG. 8C).
- FIG. 9 is a diagram for explaining the state of tissue before and after treatment.
- FIG. 9(a) shows a narrowband light image acquired by NBI observation before treatment.
- FIG. 9(b) shows a narrowband light image acquired by NBI observation after treatment. The operator irradiates the tissue with therapeutic light from the state shown in (a) of FIG. 9 and confirms the transition to the state shown in (b) of FIG. to decide.
- the narrow-band light image change calculator 413 individually calculates the change in the state of either the blood vessel structure or the fine structure OS in the obtained narrow-band light image.
- the target of change calculation can be set and can be selected from vascular structure only, fine structure only, and vascular structure and fine structure.
- the narrow-band light image change calculator 413 extracts the feature points of the image, and compares the positional changes, sizes, and distributions of the feature points to calculate changes.
- FIGS. 10A and 10B are diagrams extracting various structures of tissue states before and after treatment.
- FIG. 10A shows an image when blood vessels are extracted.
- FIG. 10B shows an image when the fine structure is extracted.
- the narrowband light image change calculation unit 413 extracts the blood vessel BV from the narrowband light images before and after the treatment, respectively, calculates the contrast value of the blood vessel, and then calculates the contrast ratio between the blood vessel BV and its surroundings. do. After that, the narrow-band light image change calculator 413 calculates the difference in contrast ratio between the narrow-band light images before and after treatment as an image change (see FIG. 10A).
- the narrow-band light image change calculation unit 413 extracts the fine structure OS of the mucosal surface layer from the narrow-band light images before and after the treatment, and calculates the clarity of the fine structure OS. After that, the narrow-band light image change calculator 413 calculates the difference in clarity between the narrow-band light images before and after the treatment as an image change (see FIG. 10B). At this time, in the narrow-band light image, the microstructure after treatment is depicted more clearly than the microstructure before treatment. Note that the narrow-band light image change calculator 413 may, for example, extract the fine structure OS and calculate the degree of matching of the fine structure OS between images as the change.
- the display image generation unit 414 generates an image to be displayed on the display device 5 (step S105: display image generation step).
- the display image generator 414 generates an image that visually expresses the narrowband light image change.
- the display image generation unit 414 generates a display image including, for example, an image obtained by arranging or superimposing the narrow band light images before and after the treatment, and visual information indicating changes in the image.
- the control unit 44 causes the display device 5 to display the image generated in step S105 (step S106: display step). By displaying an image on the display device 5, the operator can confirm the therapeutic effect.
- the operator refers to the image to confirm the therapeutic effect, determines whether to additionally irradiate the therapeutic light, and determines the portion to be irradiated with the therapeutic light.
- the operator operates the input unit 43 to input the judgment result.
- the display device 5 includes, for example, a first narrowband light image display unit W11 that displays a narrowband light image before treatment and a second narrowband light image display unit W12 that displays a narrowband light image after treatment.
- a display image W 1 (see FIG. 11) having an information display portion W 13 that displays changes in the narrowband light image before and after treatment (for example, the contrast value described above) is displayed.
- a display image W2 ( Fig . 12) is displayed on the display device 5. At this time, the size of each image of the narrow-band light images arranged in parallel and the transmittance of each image when the narrow-band light images are superimposed can be appropriately set.
- step S107 determines whether or not to additionally irradiate the therapeutic light. If the control unit 44 determines that additional irradiation of therapeutic light is unnecessary based on the input determination result (step S107: No), the process ends. On the other hand, when the control unit 44 determines that additional irradiation of therapeutic light is to be performed (step S107: Yes), the process proceeds to step S108.
- additional irradiation for example, in the illumination optical system, the shape of the irradiation range of light is controlled to match the boundary region, or the operator adjusts the spot diameter to irradiate therapeutic light.
- the control unit 44 determines whether or not the amount of irradiated light in the region where additional therapeutic light irradiation is performed is within the allowable range (step S108).
- the allowable range is a preset amount of light, and at least an upper limit value is set. This upper limit is a value set to suppress tissue damage due to excessive irradiation.
- the control unit 44 determines whether or not the amount of light (accumulated light amount value) that has been applied to the target region specified by the operator or the like exceeds the upper limit value.
- control unit 44 determines that the amount of light that has been irradiated is below the allowable range (upper limit) (step S108: Yes), it returns to step S102 and repeats the above-described processing.
- the control unit 44 determines that the amount of light that has been irradiated is below the allowable range (upper limit) (step S108: Yes)
- the latest narrow-band light image is used as the first narrow-band light image before treatment
- the narrow-band light image acquired after the drug reaction step is used.
- the band light image be the second narrow band light image.
- step S108 determines that the amount of light that has been irradiated exceeds the allowable range (upper limit) (step S108: No).
- the process proceeds to step S110.
- step S109 the control unit 44 outputs an alert to the effect that the irradiation light amount exceeds the allowable range.
- This alert may be displayed as character information on the display device 5, may be configured to emit sound or light, or may be combined. After displaying on the display device 5, the control unit 44 terminates the process.
- the change in tissue before and after treatment is calculated using a narrow-band light image, and the change is displayed, thereby allowing the operator to determine whether additional irradiation of therapeutic light is necessary.
- changes in tissues and blood vessels before and after treatment are calculated on a tissue level based on narrow-band optical images that depict tissues and blood vessels. can be irradiated with light.
- the cumulative light amount of the therapeutic light to the area is compared with the allowable range, and the cumulative light amount exceeds the allowable range. If it exceeds, an alert is output to the effect that the cumulative amount of light exceeds the allowable range. According to the first embodiment, it is possible to suppress tissue damage due to excessive irradiation of therapeutic light.
- the imaging device 244 may be configured using a multi-band image sensor to individually acquire light in a plurality of wavelength bands different from each other. For example, scattered light and returned light in a wavelength band of 380 nm to 440 nm and scattered light and returned light in a wavelength band of 530 nm to 550 nm are separately acquired by a multiband image sensor, and each narrow By generating a band light image, it is possible to individually generate blood vessel images with different depths from the mucosal surface layer, and use images of blood vessels and tissues at each depth to calculate image changes with higher accuracy. can be done.
- Embodiment 2 Next, Embodiment 2 will be described with reference to FIG. Since the endoscope system according to the second embodiment is the same as the endoscope system 1 according to the first embodiment, description thereof will be omitted. Processing different from that of the first embodiment will be described below.
- the narrowband light image change calculator 413 divides the narrowband light image into a plurality of regions and calculates the image change in each region.
- FIG. 13 is a diagram for explaining treatment effect determination processing according to the second embodiment of the present invention.
- the narrowband light image change calculator 413 divides the narrowband light image before and after treatment into four, and calculates the image change of each region (regions R A to R D ).
- the tissues in regions RA and RB are in a normal state after treatment, and the tissues in regions RC and RD contain cancer cells even after treatment. The operator observes the narrow-band image and image changes, and determines whether or not additional irradiation is necessary for each region.
- the change in the tissue before and after the treatment is calculated using the narrow-band light image, and the change is displayed so that the operator can receive additional irradiation of the treatment light.
- changes in tissues and blood vessels before and after treatment are calculated at the tissue level based on narrow-band optical images that depict tissues and blood vessels. can be irradiated with light.
- the narrow-band light is divided into a plurality of regions, and the image change in each region is calculated.
- FIG. 18 is a block diagram showing a schematic configuration of an endoscope system according to Embodiment 3 of the present invention.
- An endoscope system 1A according to the third embodiment includes a processing device 4A instead of the processing device 4 of the endoscope system 1 according to the first embodiment. Since the configuration other than the processing device 4A is the same as that of the endoscope system 1, the description is omitted.
- the processing device 4A includes an image processing unit 41A, a synchronization signal generation unit 42, an input unit 43, a control unit 44, and a storage unit 45.
- the image processing unit 41A has a white light image generation unit 411, a narrow band light image generation unit 412, a narrow band light image change calculation unit 413, a display image generation unit 414, and an estimation unit 415.
- the estimation unit 415 estimates the therapeutic effect based on the image change calculated by the narrowband light image change calculation unit 413 .
- the estimating unit 415 calculates the difference between the contrast values calculated as the image change of the narrowband light images before and after the treatment, compares the difference with a preset threshold value, and estimates the therapeutic effect. .
- the estimation unit 415 estimates that additional irradiation is necessary if the difference is smaller than the threshold.
- the estimation unit 415 estimates that the treatment is completed if the difference is equal to or greater than the threshold.
- This estimation process may be the process of step S107 in FIG. 6, or may be performed as part of the change calculation process in step S104, and the estimation result may be displayed in the display process of step S106.
- the display image generation unit 414 estimates the information to be displayed in the information display units W13 and W22 in the display images W1 and W2 shown in FIG . 11 or FIG. Generates an image transformed into a result. Note that an image that displays both the estimation result and the information on the image change may be used.
- the change in the tissue before and after treatment is calculated using the narrow-band light image, and information based on the change is displayed. to judge whether additional irradiation is necessary.
- changes in tissues and blood vessels before and after treatment are calculated at the tissue level based on narrow-band optical images that depict tissues and blood vessels. can be irradiated with light.
- the therapeutic effect is estimated from changes in the narrow-band light image, and the estimation result is used by the operator to determine the therapeutic effect from observation of the narrow-band image and image changes. It can be a suitable judgment material when doing.
- Embodiment 4 will be described with reference to FIGS. 15A and 15B. Since the endoscope system according to the fourth embodiment is the same as the endoscope system 1A according to the third embodiment, description thereof is omitted. Processing different from that of the third embodiment will be described below.
- the narrowband light image change calculator 413 calculates changes in the narrowband light image before and after treatment, or between the narrowband light image before treatment and the narrowband light image of normal tissue acquired in advance. Calculate the image change.
- the estimation unit 415 estimates the therapeutic light output (irradiation intensity) based on the image change calculated by the narrowband light image change calculation unit 413 .
- 15A and 15B are diagrams for explaining estimation processing according to the fourth embodiment of the present invention.
- the estimation unit 415 estimates the intensity of therapeutic light based on the magnitude of image change. For example, in the narrow-band image shown in (a) of FIG. 15A , if the image change from normal tissue is large, the estimating unit 415 sets the therapeutic light output to the maximum value P MAX ((b) of FIG. 15A reference). In addition, in the narrow band image shown in (a) of FIG.
- the estimating unit 415 sets the therapeutic light output to a value smaller than the maximum value P MAX ( See (b) in FIG. 15B). At this time, a threshold associated with the output value is set in advance for the image change. This estimation processing is performed before the drug reaction step in step S102 of FIG. 6 or after it is determined in step S107 that additional irradiation is to be performed (step S107: Yes).
- the display image generation unit 414 When displaying the estimation result, the display image generation unit 414 displays information indicating the therapeutic light output as the estimation result in the information display units W13 and W22 in the display images W1 and W2 shown in FIG . 11 or FIG. Generates an image that displays It should be noted that an image that displays both the estimation result and the information on the image change may be used. The operator observes the narrow-band image and image changes, and refers to the estimated therapeutic light output value to determine whether or not additional irradiation is necessary for each region and the output (energy) of the therapeutic light.
- a change in tissue before and after treatment is calculated using a narrow-band light image, and information based on the change is displayed, thereby providing the operator with therapeutic light. to judge whether additional irradiation is necessary.
- changes in tissues and blood vessels before and after treatment are calculated at the tissue level based on narrow-band optical images that depict tissues and blood vessels. can be irradiated with light.
- the output of therapeutic light is estimated based on the narrow-band light image, and the estimation result is a suitable material for the operator to make a judgment when irradiating the therapeutic light. can be.
- Embodiment 5 will be described with reference to FIGS. 16A and 16B. Since the endoscope system according to the fifth embodiment is the same as the endoscope system 1A according to the third embodiment, description thereof will be omitted. Processing different from that of the third embodiment will be described below.
- the narrow-band light image change calculator 413 calculates changes in the narrow-band light image before and after treatment, or between the narrow-band light image before treatment and the narrow-band light image of normal tissue acquired in advance. Calculate the image change.
- the estimation unit 415 estimates the required irradiation intensity of therapeutic light based on the image change calculated by the narrowband light image change calculation unit 413 .
- 16A and 16B are diagrams for explaining estimation processing according to the fifth embodiment of the present invention.
- the estimation unit 415 estimates the irradiation time of the therapeutic light based on the magnitude of the image change. At this time, it is assumed that the therapeutic light has a preset output. For example, in the narrowband image shown in (a) of FIG. 16A , if the image change from normal tissue is large, the estimation unit 415 sets the irradiation time, for example, 70 minutes, according to the magnitude of the image change. In addition, in the narrow band image shown in (a) of FIG.
- the estimation unit 415 sets, for example, 15 minutes. At this time, a threshold associated with the irradiation time is set in advance with respect to the image change. This estimation processing is performed before the drug reaction step in step S102 of FIG. 6 or after it is determined in step S107 that additional irradiation is to be performed (step S107: Yes).
- the display image generation unit 414 When displaying the estimation result, the display image generation unit 414 indicates the irradiation time of the therapeutic light as the estimation result in the information display portions W13 and W22 in the display images W1 and W2 shown in FIG . 11 or FIG. An image for displaying information (see, for example, (b) of FIG. 16A and (b) of FIG. 16B) is generated. Note that an image that displays both the estimation result and the information on the image change may be used. The operator observes the narrow-band image and image changes, refers to the estimated irradiation time of the therapeutic light, and judges whether or not additional irradiation is necessary for each region and the irradiation time of the therapeutic light.
- a narrow-band optical image is used to calculate changes in tissue before and after treatment, and information based on the changes is displayed, thereby providing the operator with therapeutic light. to judge whether additional irradiation is necessary.
- changes in tissues and blood vessels before and after treatment are calculated based on narrow-band optical images in which tissues and blood vessels are visualized, and the treatment effect is calculated at the tissue level. can be irradiated with light.
- the configuration is such that the irradiation time of the therapeutic light is estimated based on the narrow-band light image.
- the fifth embodiment may be combined with the fourth embodiment to output an estimation result obtained by combining the therapeutic light output and the irradiation time.
- the estimation unit 415 prepares in advance a narrow-band light image for comparison associated with the therapeutic light output and irradiation time, and the narrow-band light image for comparison is prepared in advance. and the feature amount of the narrow-band light image to be processed may be compared to estimate the therapeutic light output and irradiation time.
- FIG. 17 is a block diagram showing a schematic configuration of an endoscope system according to Embodiment 6 of the present invention.
- An endoscope system 1B according to the fourth embodiment has the same configuration as the endoscope system 1 according to the first embodiment.
- the processing device 4 is electrically connected to the treatment instrument device 6 , and the controller 44 controls emission of therapeutic light from the treatment instrument 62 .
- the processing device 4 performs processing according to the flow of FIG. 6 when performing PIT.
- the control unit 44 controls the irradiation range, irradiation timing, and irradiation time of the therapeutic light. Specifically, the control unit 44 sets, for example, the light intensity (output value) and the irradiation time corresponding to the preset irradiation light amount for the irradiation range set by the operator.
- the control unit 44 starts irradiation control of the treatment light with the pressing of the switch of the operation input unit 611 as a trigger.
- control unit 44 when performing additional irradiation, sets the shape of the irradiation range of the therapeutic light emitted from the treatment instrument 62 according to the boundary region of the target, and presses the switch of the operation input unit 611 as a trigger. Irradiation control of therapeutic light is started. Further, in the sixth embodiment, the control unit 44 performs control to alternately emit the narrowband light and the therapeutic light according to the flowchart of FIG. The narrowband light and therapeutic light may be emitted simultaneously.
- the light source device 3 is separate from the processing device 4 in the first to sixth embodiments described above, the light source device 3 and the processing device 4 may be integrated.
- the light source device 3 may be configured to emit therapeutic light.
- the light source device 3 includes an excitation light source realized using a light source such as an LED light source or a laser light source.
- the excitation light and the treatment light may be in the same wavelength band (same center wavelength) or different wavelength bands (center wavelength).
- the treatment light (excitation light) may be emitted from the treatment tool 62 or the excitation light source, and either the excitation light source or the treatment tool 62 may be omitted.
- exciting the PIT antibody drug for example, near-infrared light L P with a central wavelength of 690 nm is used.
- the endoscope system is the endoscope system 1 using the flexible endoscope 2 whose observation target is a biological tissue in the subject.
- the camera head is connected to the eyepiece of an optical endoscope such as a rigid endoscope, an industrial endoscope that observes the properties of materials, a fiberscope, or an optical viewing tube. It can also be applied to the endoscope system used.
- the phototherapy device, phototherapy method, and phototherapy program according to the present invention are useful for appropriately confirming therapeutic effects.
- Reference Signs List 1 1A endoscope system 2 endoscope 3 light source device 4, 4A processing device 5 display device 6 treatment instrument device 21 insertion section 22 operation section 23 universal cord 24 tip section 25 bending section 26 flexible tube section 31 light source section 32 Illumination control section 33 Light source driver 41 Image processing section 42 Synchronization signal generation section 43 Input section 44 Control section 45 Storage section 61 Treatment instrument operation section 62 Treatment instrument 241 Light guide 242 Illumination lens 243 Optical system 244 Imaging device 311 White light source 312 Narrow band Light source 411 White light image generator 412 Narrowband light image generator 413 Narrowband light image change calculator 414 Display image generator 415 Estimator
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Abstract
Description
1.癌細胞への直接傷害作用
2.血流変化に起因する間接傷害作用
3.免疫活性化に起因する間接障害作用
また、癌が拡大すると、毛細血管が増え粘膜表面が込み入った模様に変わることが知られている。上記2の血流変化に起因する間接傷害作用によって、治療光照射部位周辺では、粘膜表層の毛細血管と粘膜微細模様とが変化する。そのため、粘膜表層の毛細血管および粘膜微細模様の変化は、治療効果を確認するのに重要な指標となる。
図1は、本発明の実施の形態1に係る内視鏡システムの概略構成を示す図である。図2は、本実施の形態1に係る内視鏡システムの概略構成を示すブロック図である。図3は、本実施の形態1にかかる内視鏡の先端構成を説明する図である。
なお、PITの抗体薬剤を励起させる場合、例えば690nmを中心波長とする近赤外光(例えば図4に示す660nm以上710nm以下の波長帯域の光LP)が用いられる。
ここで、光学系243、撮像素子244および画像生成部によって、画像取得部が構成される。例えば、狭帯域光の照明によって形成される像を取得する場合、光学系243、撮像素子244および狭帯域光画像生成部412は狭帯域光画像取得部を構成する。
このため、光源装置3、画像処理部41、制御部44、内視鏡2は、生成された同期信号によって、互いに同期をとって動作する。
ここで、処置具62が備える照明光学系は、治療光の照射範囲を変更できる構成としてもよい。例えば、処置具操作部61の制御のもと、焦点距離を変更可能な光学系や、DMD(Digital Micromirror Device)等によって構成され、被写体に照射する光のスポット径や、照射範囲の形状を変更することができる。
術者は、白色光画像を観察して腫瘍B1、B2を含む領域を照射領域として決定する。また、必要に応じて、照射領域に狭帯域光を照射して、狭帯域光画像を取得する。
ここで、ステップS101~S103の順で狭帯域光と治療光とを交互に切り替えて照明することによって、漏れ光等を抑制して取得する画像の画質を向上させることができる。なお、治療前後の状態を確認するうえでは治療前、治療後にそれぞれ狭帯域光を照射することが好ましいが、ステップS101およびS102、または、ステップS102およびS103を同時に実施してもよい。
追加照射を行う際には、例えば照明光学系において、光の照射範囲の形状を境界領域に合わせる制御を行ったり、術者がスポット径を調整したりして治療光の照射を行う。
次に、実施の形態2について、図13を参照して説明する。本実施の形態2にかかる内視鏡システムは、実施の形態1にかかる内視鏡システム1と同じであるため、説明を省略する。以下、実施の形態1とは異なる処理について説明する。
次に、実施の形態3について、図18および図19を参照して説明する。図18は、本発明の実施の形態3にかかる内視鏡システムの概略構成を示すブロック図である。本実施の形態3にかかる内視鏡システム1Aは、実施の形態1にかかる内視鏡システム1の処理装置4に代えて処理装置4Aを備える。処理装置4A以外の構成は内視鏡システム1と同じであるため、説明を省略する。
次に、実施の形態4について、図15A、15Bを参照して説明する。本実施の形態4にかかる内視鏡システムは、実施の形態3にかかる内視鏡システム1Aと同じであるため、説明を省略する。以下、実施の形態3とは異なる処理について説明する。
術者は、狭帯域画像や画像変化を観察するとともに、治療光の推定出力値を参照し、各領域について追加照射が必要か否か、および、治療光の出力(エネルギー)を判断する。
次に、実施の形態5について、図16A、16Bを参照して説明する。本実施の形態5にかかる内視鏡システムは、実施の形態3にかかる内視鏡システム1Aと同じであるため、説明を省略する。以下、実施の形態3とは異なる処理について説明する。
術者は、狭帯域画像や画像変化を観察するとともに、治療光の推定照射時間を参照し、各領域について追加照射が必要か否か、および、治療光の照射時間を判断する。
次に、実施の形態6について、図17を参照して説明する。図17は、本発明の実施の形態6にかかる内視鏡システムの概略構成を示すブロック図である。本実施の形態4にかかる内視鏡システム1Bは、実施の形態1にかかる内視鏡システム1と同じ構成を備える。内視鏡システム1Bでは、処理装置4が、処置具装置6と電気的に接続し、制御部44によって、処置具62からの治療光の出射制御を行う。
また、本実施の形態6において、制御部44は、図7のフローチャートにしたがって、狭帯域光と治療光とを交互に出射する制御を行う。なお、狭帯域光と治療光を同時に出射してもよい。
治療対象部位に光治療用の薬剤を投与する工程と、
前記治療対象部位に狭帯域光を照射して、治療前の狭帯域光画像を取得する工程と、
前記治療対象部位に治療光を照射して、治療対象部位に結合させた薬剤を反応させる工程と、
前記治療対象部位に狭帯域光を照射して、治療後の狭帯域光画像を取得する工程と、
前記治療前後の前記狭帯域光画像の時間的な変化を算出する工程と、
前記狭帯域光画像の時間的な変化を用いて、治療光の照射を継続するか否かを判断する工程と、
を含む光治療方法。
2 内視鏡
3 光源装置
4、4A 処理装置
5 表示装置
6 処置具装置
21 挿入部
22 操作部
23 ユニバーサルコード
24 先端部
25 湾曲部
26 可撓管部
31 光源部
32 照明制御部
33 光源ドライバ
41 画像処理部
42 同期信号生成部
43 入力部
44 制御部
45 記憶部
61 処置具操作部
62 処置具
241 ライトガイド
242 照明レンズ
243 光学系
244 撮像素子
311 白色光源
312 狭帯域光源
411 白色光画像生成部
412 狭帯域光画像生成部
413 狭帯域光画像変化算出部
414 表示画像生成部
415 推定部
Claims (12)
- 薬剤を反応させる治療光を出射する治療光出射部と、
可視光域の一部の波長帯域の光からなる狭帯域光を出射する狭帯域光出射部と、
前記治療光の照射位置に照射された狭帯域光によって得られる狭帯域光画像を取得する狭帯域光画像取得部と、
前記治療光の照射前後の前記狭帯域光画像の時間的な変化を算出する狭帯域光画像変化算出部と、
前記狭帯域光画像の変化に基づく情報を含む表示画像を生成する表示画像生成部と、
を備える光治療装置。 - 前記狭帯域光は、390nm以上445nm以下の波長帯域、および530nm以上550nm以下の波長帯域からなり、
前記狭帯域光画像変化算出部は、前記狭帯域光画像から血管構造を抽出し、該抽出した血管構造のコントラストの時間変化を算出する、
請求項1に記載の光治療装置。 - 前記狭帯域光は、390nm以上445nm以下の波長帯域、および530nm以上550nm以下の波長帯域からなり、
前記狭帯域光画像変化算出部は、前記狭帯域光画像から粘膜表面の構造を抽出し、該抽出した粘膜表面の構造の明瞭度の時間変化を算出する、
請求項1に記載の光治療装置。 - 前記狭帯域光は、390nm以上445nm以下の波長帯域、および530nm以上550nm以下の波長帯域からなり、
前記狭帯域光画像変化算出部は、前記狭帯域光画像から粘膜表面の構造を抽出し、該抽出した粘膜表面の構造の均一性の時間変化を算出する、
請求項1に記載の光治療装置。 - 前記治療光と、前記狭帯域光とを互いに異なるタイミング、かつ互いに重複しないタイミングでの出射を制御する制御部、
をさらに備える請求項1に記載の光治療装置。 - 前記狭帯域光画像変化算出部は、前記狭帯域光画像を複数の領域に分割し、該分割したそれぞれの領域における画像の変化量を算出する、
請求項1に記載の光治療装置。 - 前記表示画像生成部は、前記治療光の照射前の狭帯域光画像と、前記治療光の照射後の狭帯域光画像とを並べた表示画像を生成する、
請求項1に記載の光治療装置。 - 前記表示画像生成部は、前記治療光の照射前の狭帯域光画像と、前記治療光の照射後の狭帯域光画像とを重ねた表示画像を生成する、
請求項1に記載の光治療装置。 - 前記狭帯域光画像変化算出部が算出した画像の変化に基づいて、前記治療光の出力を推定する推定部、
をさらに備える請求項1に記載の光治療装置。 - 前記狭帯域光画像変化算出部が算出した画像の変化に基づいて、前記治療光の照射時間を推定する推定部、
をさらに備える請求項1に記載の光治療装置。 - 薬剤を反応させる治療光を、治療部位に照射して治療効果を確認するための光治療方法であって、
前記治療光照射前の前記治療部位に対して、可視光域の一部の波長帯域の光からなる狭帯域光を照射して得られる第1狭帯域光画像を取得する第1狭帯域光画像取得ステップと、
前記治療光照射後の前記治療部位に対して、前記狭帯域光を照射して得られる第2狭帯域光画像を取得する第2狭帯域光画像取得ステップと、
前記第1および第2狭帯域光画像の時間的な変化を算出する狭帯域光画像変化算出ステップと、
前記狭帯域光画像の変化に基づく情報を含む表示画像を生成する表示画像生成ステップと、
を含む光治療方法。 - 薬剤を反応させる治療光を、治療部位に照射して治療効果を確認するため情報を生成する光治療装置に、
前記治療光照射前の前記治療部位に対して、可視光域の一部の波長帯域の光からなる狭帯域光を照射して得られる第1狭帯域光画像を取得する第1狭帯域光画像取得ステップと、
前記治療光照射後の前記治療部位に対して、前記狭帯域光を照射して得られる第2狭帯域光画像を取得する第2狭帯域光画像取得ステップと、
前記第1および第2狭帯域光画像の時間的な変化を算出する狭帯域光画像変化算出ステップと、
前記狭帯域光画像の変化に基づく情報を含む表示画像を生成する表示画像生成ステップと、
を実行させる光治療プログラム。
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JP2012024283A (ja) * | 2010-07-22 | 2012-02-09 | Fujifilm Corp | 内視鏡診断装置 |
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