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  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2/00—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms
  • C07C2/02—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons
  • C07C2/42—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by addition between unsaturated hydrocarbons homo- or co-oligomerisation with ring formation, not being a Diels-Alder conversion
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  • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
  • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
• • C—CHEMISTRY; METALLURGY
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  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2/00—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms
  • C07C2/86—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by condensation between a hydrocarbon and a non-hydrocarbon
  • C07C2/861—Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by condensation between a hydrocarbon and a non-hydrocarbon the non-hydrocarbon contains only halogen as hetero-atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C253/00—Preparation of carboxylic acid nitriles
  • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
  • C07C29/32—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of -OH groups
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
  • C07C41/01—Preparation of ethers
  • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
  • C07C41/01—Preparation of ethers
  • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
  • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C43/00—Ethers; Compounds having groups, groups or groups
  • C07C43/02—Ethers
  • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
  • C07C43/04—Saturated ethers
  • C07C43/115—Saturated ethers containing carbocyclic rings
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C67/00—Preparation of carboxylic acid esters
  • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
  • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
  • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
  • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
  • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
  • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
  • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
  • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
  • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2602/00—Systems containing two condensed rings
  • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
  • C07C2602/14—All rings being cycloaliphatic
  • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Definitions

• This invention relates to a process of preparing cyclopropanated compounds.
• a common cyclopropanation reaction is the Simmons-Smith reaction (see Simmons, H. E; Cairns, T. L.; Vladuchick, S. A.; Hoiness, C. M. Org. React. (N. Y.) 1973, 20, 1 - 131), which utilises diiodomethane and Zn(Cu).
• the invention therefore provides a process for the cyclopropanation of a substituted alkene, comprising the reaction of the alkene with a carbenoide, generated from dibromomethane and a tri-(C 2 - C 8 )-alkyl aluminium compound in the presence of a catalytic amount of a metal compound selected from the group consisting of Lewis acids other than tri-(C 2 - C 8 )-alkyl aluminium compounds, metallocenes and metal carbonyl complexes.
• catalytic amount is meant an amount of less than one molar equivalent of metal compound with more than one molar equivalent of reactant with the result that more than one molar equivalent of product is obtained.
• This method not only gives good yields of the product but is also free from the generation of zinc- and copper-containing residues.
• the advantage gained by the metal compounds is that the reaction rate of the cyclopropanation reaction is enhanced, thus allowing the use of less dibromomethane and trialkyl aluminum as well as a significantly decreased reaction temperatures.
• the C 2 - C 8 alkyl moieties may include alkanes, substituted alkanes, cycloalkanes and substituted cycloalkanes.
• the (C 2 - C 8 ) alkyl aluminium compound is preferably triisobutyl aluminium (TIBA).
• the method is applicable to electron-rich alkenes.
• alkenes include mono-, di- , tri- or tetra-substituted alkenes.
• the substituents may be selected from saturated and unsaturated alkyl and aryl groups, which themselves may be substituted with functional groups, such as (but not limited to) acids, esters, alcohols, ethers, allyl alcohols, allyl ethers, amines, allyl amines, imines, alkenes, aldehydes, cyclopropanes and ketones.
• Alkenes with which the invention works especially well are alkenes bearing at least three substituents including alkenes embedded in ring structures with ring sizes of 3 to 20 carbon- or hetero- atoms, which rings themselves can be substituted, for example, with the same substituents as hereinabove described.
• alkenes that undergo the cyclopropanation reaction of this invention including combinations of reactive alkenes and unreactive alkenes in the same molecule, include those with the following structures:
• alkenes may also include in the same molecule alkene moieties that are not electron-rich or alkenes that contain functional groups in their allylic position, which undergo complex formation with the alkyl aluminium compound, e.g.
• alkenes sterically against cyclopropanation.
• unreactive alkenes are allylic alcohols, allylic amines, as well as electron-deficient alkenes such as conjugated carbonyl compounds, conjugated nitriles, conjugated imines and conjugated oximes. If these unreactive alkenes are combined in the same molecule with electron-rich reactive ones, only the latter will undergo cyclopropanation, with high chemoselectivity.
• the metal compounds whose presence is essential to the working of the invention are selected from the group consisting of metallocenes, metal carbonyl complexes and Lewis acids other than tri-(C 2 - C 8 )-alkyl aluminium compounds.
• metallocenes metal carbonyl complexes
• Lewis acids other than tri-(C 2 - C 8 )-alkyl aluminium compounds One or more of these metal compounds can be used.
• tri-(C 2 - C 8 )-alkyl aluminium compounds are themselves weak Lewis acids, it has been found that they alone do not give the benefits of the invention, and when Lewis acids are desired as the metal compounds, Lewis acids other than these tri-(C 2 - C 8 )-alkyl aluminium compounds must be added.
• Examples of efficient Lewis acids include FeCl 2 and FeCl 3 , which are preferably used at a concentration of 0.01 - 30%, preferably 1 - 10%, with respect to the alkene to be cyclopropanated (the starting material).
• Examples of efficient metallocenes are those with at least one cyclopentadienyl-ligand, e.g. cyclopentadienyltitanium trichloride CpTiCl 3 or cyclopentadienyliron dicarbonyl dimer [CpFe(CO) 2 ] 2 , which are used at the concentrations hereinabove described.
• An example of a metal carbonyl complex is iron pentacarbonyl Fe(CO) 5 .
• the addition has the advantage of allowing the reaction to be carried out in less dibromomethane, typically 20 molar equivalents instead of 30 eq, and at lower temperatures, thus increasing the margin of safety, because above 85°C an exothermic decomposition of the reaction mass is possible.
• this reaction proceeds as follows:
• the excess dibromomethane is recovered.
• a recovery reduces costs and makes the process more industrially viable. The recovery is carried out by the steps of:
• recovery may be achieved.by the following steps:
• reaction mixture is added to aqueous base (preferably 25% NaOH) at a temperature of from -10° - 0°C.
• aqueous base preferably 25% NaOH
• Isobutane is cleaved from the isobutyl aluminium reagent and remains liquefied in the target vessel.
• the resulting two-phase mixture is slowly and under stirring warmed to room temperature. This causes the release of gaseous isobutane, which is collected in a cooling device;
• phase separation and addition of isopropanol to the organic phase the organic phase is dried azeotropically and the excess dibromomethane is evaporated under reduced pressure 5 and finally purified by distillation.
• the process described in this invention permits the cyclopropanation of electron-rich olefins in a cheap and efficient manner.
• the aluminium- and iron-containing wastes are environmentally of relatively low concern, the solvent dibromomethane can be recycled, and the collected 10 isobutane can be used for other purposes or can be burned.
• the process has many uses, including the relatively easy and inexpensive manufacture of flavour and fragrance ingredients.
• Campholene alcohol (EP 0 116 903) (8 g, 50 mmol) in dibromomethane (72 ml) is treated under cooling (10° - 2O 0 C) with neat TIBA (6.5 ml, 25 mmol) via syringe. After 15 min stirring anhydrous FeCl 3 (0.5 g, 3 mmol) is added followed by neat TIBA (39 ml, 0.15 mol).
• Example 2 trans-[ 1 -Methyl-2-(l ,2,2,5-tetramethyl-bicyclo[3.1.0]hex-3-ylmethyl)-cyclopropyl]methanol.
• the mixture is stirred for 4.5 h at 25 0 C, then cooled to -10° - 0 0 C and pumped via double needle on to cooled (-10° - O 0 C) 25% NaOH. Under stirring (Caution ! the biphasic mixture is 5 slowly warmed to room temperature. The evolving isobutane is collected in a cooling trap at -78 0 C. The phases are separated. The organic phase is washed with 4% oxalic acid, then with cone. NaHCO 3 until pH ⁇ 8. Isopropanol (HO g, 1.8 mol) is added to the organic phase and the water is removed azeotropically under reduced pressure.
• To Nor-Radjaldehyde (US 4,052,341) (192 g, 1 mol) is added at 0 0 C and stirring neat DIBAH (179 ml, 1 mol) via double needle, The solution is stirred for 30 min at.25°C ⁇ Dibromomethane, (2.1 1, 30 mol) is added and the solution heated to 6O 0 C, where neat TIBA (595 g, 3 mol) is 25 added over 2 h via double-needle. The reaction temperature is maintained by slight external cooling at 65 - 75°C for another 2 - 4 h, until complete conversion is detected by GC.
• Example 2 In comparison with Example 1, it can be seen that, without FeCl 3 , more TIBA and dibromomethane are required and that a higher reaction temperature is necessary. The use of FeCl 3 allows a better, more economic process.
• Linalool 5-(2,2-Dimethyl-cyclopropyl)-3-methyl-pent-l- en-3-ol
• FeCl 3 (0.5 g, 3 mmol) is added under stirring to 6-Methyl-hept-5-en-2-one (6.3 g, 50 mmol) in dibromomethane (70 ml, 1 mol) at 10° - 20°C, followed by slow addition of neat TIBA (38 ml, 0.15 mol) at this temperature. The mixture is stirred for 7 h at 25 0 C, then poured carefully on to 25% NaOH at -10° - 0°C. Work-up as described in example 1 and distillation (bp 50 0 C / 0.07 Torr) gives 4.8 g (67%) of a colorless oil (80% GC-purity, dr - 1:1).
• the analytical data (NMR, MS, IR) are consistent with the ones described in the literature (Perraud, R; Arnaud, P. Bull. Chem. Soc. Chim. Fr. 1968, 1540 - 1542).
• GC/MS 210 (0.1%, M + ), 195 (4%, [M - 15] + ), 153 (10%), 136 (35%), 82 (45%), 55 (100%).
• IR (film) 2925 (m), 2869 (m), 1719 (s), 1648 (m), 1453 (m), 10 1366 (m), 1219 (m), 1147 (s), 1042 (m), 970 (w), 859 (w).
• Example 13 Cyclopropanation of NirvanolideTM: ezs-3-Methyl-6-oxa-bicyclo[13.1.0]hexadecan-7-one.
• Example 14 trans-3 -(2-Ethoxymethyl-2-methyl-cyclopropylmethyl)- 1 ,2,2-trimethyl-bicyclo- [3.1. OJhexane.

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