WO2005000251A1 - Promoteurs de recalcification et compositions de soin buccal - Google Patents

Promoteurs de recalcification et compositions de soin buccal Download PDF

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Publication number
WO2005000251A1
WO2005000251A1 PCT/JP2004/006625 JP2004006625W WO2005000251A1 WO 2005000251 A1 WO2005000251 A1 WO 2005000251A1 JP 2004006625 W JP2004006625 W JP 2004006625W WO 2005000251 A1 WO2005000251 A1 WO 2005000251A1
Authority
WO
WIPO (PCT)
Prior art keywords
calcium
silk
remineralization
hydrolyzate
sericin
Prior art date
Application number
PCT/JP2004/006625
Other languages
English (en)
Japanese (ja)
Inventor
Koichi Okano
Kiminori Atsumi
Shuji Sakuma
Original Assignee
Kabushiki Kaisha Sangi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabushiki Kaisha Sangi filed Critical Kabushiki Kaisha Sangi
Priority to JP2005510984A priority Critical patent/JP4937583B2/ja
Publication of WO2005000251A1 publication Critical patent/WO2005000251A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds

Definitions

  • the present invention relates to a remineralization accelerator for tooth enamel, and to an oral composition produced by adding the remineralization accelerator.
  • Dental decay begins when the dental caries bacteria adhere to the tooth surface and form dental plaque, and the acid produced by the dental caries metabolizing food in the dental plaque demineralizes tooth enamel. To create an initial corrosion state. Saliva remineralizes this demineralized part by the action of calcium and phosphorus in saliva, and has the function of returning the teeth to their original state.
  • dentifrices containing hydroxyapatite which is one of fluoride and calcium phosphate and has a crystal structure similar to the inorganic component of teeth, have been manufactured. While using the saliva, fluoride and hydroxyapatite dentifrice, remineralization of the demineralized part is not enough.
  • an oral composition containing sinorek powder and dextranase JP-A-2000-63251
  • an enzyme By providing a disintegrable silk powder having immobilized thereon, it provides an oral composition excellent in plaque adhesion inhibitory effect and removal effect, and excellent in usability (Japanese Patent Laid-Open No. 2001-226243).
  • Dentifrice composition Japanese Patent Laid-Open No. 2001-278757 in which silk powder is blended with fatty acid esters and collagen compounds to enhance the UV absorption effect. Silk powder and condensed phosphate are used to prevent coloring stains on teeth.
  • Patent Document 1 JP-A-2000-63251
  • Patent Document 2 JP 2001-226243 A Patent Document 3: Japanese Patent Application Laid-Open No. 2001-278757
  • Patent Document 4 JP 2001-288061 A
  • Patent Document 5 JP-A-2002-255770
  • the present invention provides an oral composition having an excellent remineralizing effect, which effectively promotes remineralization of demineralized enamel and thereby can actively inhibit dental erosion. This is for the purpose of providing.
  • the present invention provides a method for promoting remineralization of teeth by using silk powder, sericin, a protein component of silk, and / or a hydrolyzate thereof, which is a protein component of silk. It has been found that recalcification of teeth is further promoted by using a calcium compound such as in combination, and the present invention has been accomplished.
  • composition for oral cavity of the present invention is produced by adding the above-mentioned tooth enamel remineralization accelerator.
  • the present invention relates to a composition for oral cavity comprising silk powder, serinocin which is a sinolek protein, fibrin, and Z or a hydrolyzate thereof, and silk.
  • a composition for oral cavity comprising silk powder, serinocin which is a sinolek protein, fibrin, and Z or a hydrolyzate thereof, and silk.
  • an oral composition characterized by containing powder, sericin, silk protein which is a silk protein, and a hydrolyzate thereof, and a calcium compound such as hydroxyapatite.
  • Silk powder is a powder obtained by pulverizing silk obtained from the silkworm, the silkworm moth, with 70-80% fib mouth and 30-20% sericin.
  • the used silk powder, silk protein sericin, fiber mouth, and hydrolyzate thereof can be obtained by a conventionally known method, and the production method is not limited.
  • Silk protein can be obtained as a silk extract by extracting silk fibers with a dilute sulfuric acid solution.
  • a water-insoluble protein obtained by treatment with water, hydrous alcohol, etc. which can be extracted from a solution dissolved in an aqueous solution of urea and guanidine hydrochloride. Also disclosed is a method of removing refined silk fibers from a solution of a dissolved neutral salt (JP-A-2001-54359).
  • the hydrolyzate of fiber mouth can be obtained by hydrolyzing fiber mouth using various acids, anorecali and proteolytic enzymes.
  • Sericin is a water-soluble protein obtained by treating Shinorek with hot water, cold water, hydrous alcohol, or the like, and is hydrolyzed using an alkali or a protease to obtain a hydrolyzate of sericin. .
  • the above-mentioned silk powder, silk protein and hydrolyzate thereof are dissolved or dispersed in a suitable liquid, or mixed with a suitable powder carrier or adsorbed on the powdered carrier. It is also possible to add dispersants, turbidity agents, spreading agents, penetrants, wetting agents or stabilizing agents, etc. and formulate them into emulsions, wettable powders, powders or tablets for use.
  • Calcium compounds include powders obtained by crushing natural hard tissues such as bones and eggshell shells of fish, amphibians, reptiles, birds or mammals living in seawater or freshwater, calcium chloride, calcium carbonate, and the like. , Calcium lactate, calcium dalconate, hydroxyapatite, tricalcium phosphate, calcium citrate, calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, calcium oxide, etc. Apatite is preferred.
  • Hydroxyapatite crystals constituting the enamel on the tooth surface are composed of calcium phosphate and are considered to be effective as a supply source of calcium and phosphoric acid.
  • the calcium compound in addition to those synthesized by an ordinary method, those containing abundant calcium compound as the above-mentioned natural hard tissue are used in the present invention. Examples include fish bone, pork bone, and cow bone of edible fish such as salmon.
  • Examples of the oral composition of the present invention include dentifrices such as toothpaste, powdered toothpaste, and liquid toothpaste, mouthwashes, 3DS gingival matsuzane cream, gargle tablets, troches and the like. It is difficult to determine the amount of caloric addition of sinorek powder, sinorek protein and its hydrolyzate to the oral composition, and the amount of calcium compound to be added to the oral composition depending on the form of the oral composition. 001—50.0% by weight, 0.01% —50.0% by weight is preferred.
  • the silk powder, the silk protein or its hydrolyzate, and the calcium compound may be added during the production process of the product, at an appropriate time, or by mixing the remaining ingredients. Les ,.
  • a silk powder, a silk protein or a hydrolyzate thereof, and a calcium compound may be mixed in advance and added separately, that is, separately from the silk powder.
  • a silk protein, a hydrolyzate thereof, and a calcium compound may be separately added.
  • the oral composition of the present invention may be in the form of a dentifrice such as a toothpaste, a liquid dentifrice, a powdered dentifrice, a mouthwash, a 3DS formulation gingival matsuzazi cream, a gargle tablet, a troche and the like.
  • a dentifrice such as a toothpaste, a liquid dentifrice, a powdered dentifrice, a mouthwash, a 3DS formulation gingival matsuzazi cream, a gargle tablet, a troche and the like.
  • Can be used in The oral composition of the present invention can contain additives, wetting agents, foaming agents, flavors, sweeteners, preservatives, various active ingredients and the like usually used in dentifrice compositions. Specific examples of these components are shown below.
  • Abrasives calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate and the like.
  • Wetting agent glycerin, propylene glycol, polyethylene glycol, etc.
  • Blowing agents sodium lauryl sulfate, N-lauroyl sarcosine sodium, nonionic surfactants, etc.
  • Thickeners hydroxyethylcellulose, sodium carboxymethylcellulose, carrageenan, carboxyvinyl polymer, chitansan gum and the like.
  • Preservatives paraoxybenzoate, alkyldiaminoethyldaricin hydrochloride, methylparaben, ethylparaben, sodium benzoate and the like.
  • Flavors menthol, spearmint oil, lemon oil, eucalyptus oil, etc.
  • Sweetener saccharin sodium, stevia extract, aspartame and the like.
  • the remineralizing accelerator of the present invention comprises silk powder, sericin, fibrous mouth and their carohydrates, and silk powder, sericin, fibrous inn and hydrolysates thereof, and hydroxyapatite.
  • the oral composition of the present invention which contains a calcium compound such as a calcium compound as an active ingredient and is produced by adding the above-mentioned remineralization accelerator effectively promotes remineralization of demineralized tooth enamel. However, it is advantageous for actively suppressing erosion.
  • FIG. 1 is a photograph showing a control surface and a treated surface of a crown by a contact microradiogram (CMR).
  • CMR contact microradiogram
  • FIG. 2 is a drawing in which the photograph shown in FIG. 1 is drawn using dark ink and explanation of the state of each part is attached.
  • the artificial initial caries test sample was prepared by removing the dirt and deposits on the enamel surface using the crown of human extracted teeth that had not been subjected to dental preservation and prosthesis treatment. Create a 3.5 x 3. Omm window with Nail Enamel for the test target site, and place it in 0.1 M lactate buffer (pH 4.5, 3. OmmCaCl, 1.8 mmKHPO, 0.5% CMC) 37. C, soak for 7 days It was immersed to create an artificial initial caries. As a control for the test, half of the 3.5 x 3. Omm window on the crown apex side was masked with Nail Enamel and used as a comparison target (control).
  • test solution was a dentifrice, liquid dentifrice, liquid dentifrice, and mouthwash as a suspension solution with artificial saliva.
  • the artificial initial caries test specimen prepared above was immersed in each test solution for 24 hours, and then the specimen was subjected to a micro cutter so as to be parallel to the tooth axis. The pieces were cut to a thickness of 5 OO xm, and then the sections were polished using a kneading whetstone and a natural whetstone to form parallel thin sections of about 100 ⁇ 100 ⁇ thickness under water injection. After polishing, contact microradiogram (CMR) was performed to confirm the remineralization effect of the teeth (see Fig. 1 and Fig. 2). The analysis was performed using a computer.
  • CMR contact microradiogram
  • Image analysis using a computer is based on the formula of Angmer et al. (B. Angmer, D. Carlstrom and
  • JEGlas Studies on Ultrastructure of Dental Enemei iV: The Mineralization of normal Human Enamel, J. Ultrastructure. Res. 8, 12-23, 1963) According to the method (FA Damato, R. Stang and KW Stephen: Effect of Fluoride Concentration on Remmerelization of anous Enamel: an m vitro pH-Cycling Study, Caries Res, 24, 174-180, 1990), The amount of mineral loss AZ (% volume mineral ' ⁇ m) on the treated surface was calculated. The remineralization rate was calculated by the following formula.
  • Table 5 shows the results of confirming the effect of promoting remineralization by the above-described remineralization acceleration test method.
  • Example Comparative Example 4 Example 12 Example 13 Example 14 Example 15 Liquid dentifrice Remineralization rate
  • control surface in the figure is a part for comparing the degree of the remineralization effect of the “oral compositions” in Examples and Comparative Examples. The state of "eclipse” is maintained. Half of the artificial erosion (3.5X3. Omm window) area.
  • the “processed surface” in the figure refers to a portion where the specimens of Examples and Comparative Examples acted as follows.
  • test substance was prepared using a suspension of dentifrice, mouthwash, and artificial saliva as the test solution.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne des compositions de soin buccal qui activent efficacement la recalcification d'émail décalcifié et qui empêchent activement l'apparition de caries. Une composition de soin buccal se caractérise en ce qu'elle contient de la poudre de soie, de la séricine ou de la fibroïne (c'est-à-dire des protéines de soie) et/ou des hydrolysats de ces derniers; et une composition de soin buccal qui se caractérise en ce qu'elle contient une poudre de soie, de la séricine ou de la fibroïne (c'est-à-dire des protéines de soie) et/ou des hydrolysats de ces derniers ainsi qu'un composé de calcium représenté par l'hydroxyapatite.
PCT/JP2004/006625 2003-06-30 2004-05-17 Promoteurs de recalcification et compositions de soin buccal WO2005000251A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2005510984A JP4937583B2 (ja) 2003-06-30 2004-05-17 口腔用組成物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2003187099 2003-06-30
JP2003-187099 2003-06-30
JP2003308875 2003-09-01
JP2003-308875 2003-09-01

Publications (1)

Publication Number Publication Date
WO2005000251A1 true WO2005000251A1 (fr) 2005-01-06

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/006625 WO2005000251A1 (fr) 2003-06-30 2004-05-17 Promoteurs de recalcification et compositions de soin buccal

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JP (1) JP4937583B2 (fr)
WO (1) WO2005000251A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006101268A1 (fr) * 2005-03-25 2006-09-28 Seiren Co., Ltd. Utilisation de sericine pour ameliorer la sensation d'une prothese dentaire lors de l'utilisation
JP2007176862A (ja) * 2005-12-28 2007-07-12 Lion Corp 口腔用組成物
JP2007254288A (ja) * 2005-03-25 2007-10-04 Seiren Co Ltd 義歯の表面改質剤
JP2009137860A (ja) * 2007-12-05 2009-06-25 Seiren Co Ltd 口腔ケア用組成物
JP2009155216A (ja) * 2007-12-25 2009-07-16 Lion Corp 口腔用組成物
JP2020180051A (ja) * 2019-04-23 2020-11-05 株式会社たかくら新産業 口腔ケア組成物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5683089B2 (ja) * 2009-10-20 2015-03-11 セーレン株式会社 口腔用組成物

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000063251A (ja) * 1998-08-12 2000-02-29 Lion Corp 口腔用組成物
WO2000037033A1 (fr) * 1998-12-18 2000-06-29 Henkel Kommanditgesellschaft Auf Aktien Suspensions de sels de calcium de fine dispersion et peu solubles dans l'eau et leur utilisation dans des produits d'hygiene dentaire
JP2001131042A (ja) * 1999-11-09 2001-05-15 Nippon Zettoc Co Ltd 口腔用組成物
JP2001213746A (ja) * 2000-02-01 2001-08-07 Sangi Co Ltd 口腔用組成物
JP2001226242A (ja) * 2000-02-17 2001-08-21 Lion Corp 口腔用組成物
JP2001226243A (ja) * 2000-02-17 2001-08-21 Lion Corp 口腔用組成物
JP2001278757A (ja) * 2000-03-30 2001-10-10 Kanebo Ltd 歯磨剤組成物
JP2001288061A (ja) * 2000-04-10 2001-10-16 Lion Corp 口腔用組成物
JP2002193777A (ja) * 2000-12-27 2002-07-10 Sangi Co Ltd 口腔用組成物
JP2002255770A (ja) * 2001-03-05 2002-09-11 Lion Corp 歯磨組成物

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000063251A (ja) * 1998-08-12 2000-02-29 Lion Corp 口腔用組成物
WO2000037033A1 (fr) * 1998-12-18 2000-06-29 Henkel Kommanditgesellschaft Auf Aktien Suspensions de sels de calcium de fine dispersion et peu solubles dans l'eau et leur utilisation dans des produits d'hygiene dentaire
JP2001131042A (ja) * 1999-11-09 2001-05-15 Nippon Zettoc Co Ltd 口腔用組成物
JP2001213746A (ja) * 2000-02-01 2001-08-07 Sangi Co Ltd 口腔用組成物
JP2001226242A (ja) * 2000-02-17 2001-08-21 Lion Corp 口腔用組成物
JP2001226243A (ja) * 2000-02-17 2001-08-21 Lion Corp 口腔用組成物
JP2001278757A (ja) * 2000-03-30 2001-10-10 Kanebo Ltd 歯磨剤組成物
JP2001288061A (ja) * 2000-04-10 2001-10-16 Lion Corp 口腔用組成物
JP2002193777A (ja) * 2000-12-27 2002-07-10 Sangi Co Ltd 口腔用組成物
JP2002255770A (ja) * 2001-03-05 2002-09-11 Lion Corp 歯磨組成物

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006101268A1 (fr) * 2005-03-25 2006-09-28 Seiren Co., Ltd. Utilisation de sericine pour ameliorer la sensation d'une prothese dentaire lors de l'utilisation
JP2007254288A (ja) * 2005-03-25 2007-10-04 Seiren Co Ltd 義歯の表面改質剤
EP1864644A4 (fr) * 2005-03-25 2011-06-08 Seiren Co Ltd Utilisation de sericine pour ameliorer la sensation d'une prothese dentaire lors de l'utilisation
US8097285B2 (en) 2005-03-25 2012-01-17 Seiren Co., Ltd. Use of sericin for improving the feeling in use of denture
JP2007176862A (ja) * 2005-12-28 2007-07-12 Lion Corp 口腔用組成物
JP2009137860A (ja) * 2007-12-05 2009-06-25 Seiren Co Ltd 口腔ケア用組成物
JP2009155216A (ja) * 2007-12-25 2009-07-16 Lion Corp 口腔用組成物
JP2020180051A (ja) * 2019-04-23 2020-11-05 株式会社たかくら新産業 口腔ケア組成物

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Publication number Publication date
JPWO2005000251A1 (ja) 2006-10-19
JP4937583B2 (ja) 2012-05-23

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