WO2004020415A1 - 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12. - Google Patents

2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12. Download PDF

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Publication number
WO2004020415A1
WO2004020415A1 PCT/SE2003/001328 SE0301328W WO2004020415A1 WO 2004020415 A1 WO2004020415 A1 WO 2004020415A1 SE 0301328 W SE0301328 W SE 0301328W WO 2004020415 A1 WO2004020415 A1 WO 2004020415A1
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WIPO (PCT)
Prior art keywords
dioxoimidazolidin
acetamide
ethyl
methyl
phenyl
Prior art date
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PCT/SE2003/001328
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English (en)
French (fr)
Inventor
Krister Henriksson
Magnus Munck af Rosenschöld
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority to NZ538443A priority Critical patent/NZ538443A/en
Priority to UAA200501189A priority patent/UA81635C2/ru
Priority to HK05109053.0A priority patent/HK1077061B/en
Priority to DE60310582T priority patent/DE60310582T2/de
Priority to AU2003253557A priority patent/AU2003253557B2/en
Priority to CA002495853A priority patent/CA2495853A1/en
Priority to JP2004532506A priority patent/JP2006503019A/ja
Priority to US10/525,640 priority patent/US7354940B2/en
Priority to SI200330661T priority patent/SI1542977T1/sl
Priority to MXPA05002066A priority patent/MXPA05002066A/es
Priority to BR0313635-3A priority patent/BR0313635A/pt
Priority to DK03791528T priority patent/DK1542977T3/da
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to EP03791528A priority patent/EP1542977B1/en
Publication of WO2004020415A1 publication Critical patent/WO2004020415A1/en
Priority to IL166826A priority patent/IL166826A/en
Priority to IS7767A priority patent/IS2415B/is
Priority to NO20051540A priority patent/NO20051540L/no
Priority to US11/500,207 priority patent/US7662845B2/en
Priority to CY20071100216T priority patent/CY1106027T1/el

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Definitions

  • the present invention relates to novel compounds, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
  • Metalloproteinases are a superfamily of proteinases (enzymes) whose numbers in recent years have increased dramatically. Based on structural and functional considerations these enzymes have been classified into families and subfamilies as described in N.M. Hooper (1994) FEBS Letters 354: 1-6.
  • metalloproteinases examples include the matrix metalloproteinases (MMPs) such as the collagenases (MMPl, MMP8, MMP13), the gelatinases (MMP2, MMP9), the stromelysins (MMP3, MMP10, MMPl 1), matrilysin (MMP7), metalloelastase (MMP12), enamelysin (MMP19), the MT-MMPs (MMP14, MMPl 5, MMPl 6, MMPl 7); the reprolysin or adamalysin or MDC family which includes the secretases and sheddases such as TNF converting enzymes (ADAM 10 and TACE); the astacin family which include enzymes such as procollagen processing proteinase (PCP); and other metalloproteinases such as aggrecanase, the endothelin converting enzyme family and the angiotensin converting enzyme family.
  • MMPs matrix metalloproteinases
  • Metalloproteinases are believed to be important in a plethora of physiological disease processes that involve tissue remodelling such as embryonic development, bone formation and uterine remodelling during menstruation. This is based on the ability of the metalloproteinases to cleave a broad range of matrix substrates such as collagen, * proteoglycan and fibronectin. Metalloproteinases are also believed to be important in the processing, or secretion, of biological important cell mediators, such as tumour necrosis factor (TNF); and the post translational proteolysis processing, or shedding, of biologically important membrane proteins, such as the low affinity IgE receptor CD23 (for a more complete list see N. M. Hooper et al, (1997) Biochem J. 321:265-279).
  • TNF tumour necrosis factor
  • Metalloproteinases have been associated with many diseases or conditions. Inhibition of the activity of one or more metalloproteinases may well be of benefit in these diseases or conditions, for example: various inflammatory and allergic diseases such as, inflammation of the joint (especially rheumatoid arthritis, osteoarthritis and gout), inflammation of the gastro-intestinal tract (especially inflammatory bowel disease, ulcerative colitis and gastritis), inflammation of the skin (especially psoriasis, eczema, dermatitis); in tumour metastasis or invasion; in disease associated with uncontrolled degradation of the extracellular matrix such as osteoarthritis; in bone resorptive disease (such as osteoporosis and Paget's disease); in diseases associated with aberrant angiogenesis; the enhanced collagen remodelling associated with diabetes, periodontal disease (such as gingivitis), corneal ulceration, ulceration of the skin, post-operative conditions (such as colonic anastomosis) and dermal wound healing; demyelinating diseases of
  • MMP12 also known as macrophage elastase or metalloelastase
  • MMPl 2 is preferentially expressed in activated macrophages, and has been shown to be secreted from alveolar macrophages from smokers [Shapiro et al, 1993, Journal of Biological Chemistry, 268: 23824] as well as in foam cells in atherosclerotic lesions [Matsumoto et al, 1998, Am J Pathol 153: 109].
  • a mouse model of COPD is based on challenge of mice with cigarette smoke for six months, two cigarettes a day six days a week. Wildtype mice developed pulmonary emphysema after this treatment. When MMPl 2 knock-out mice were tested in this model they developed no significant emphysema, strongly indicating that MMPl 2 is a key enzyme in the COPD pathogenesis.
  • MMPs such as MMP12 in COPD (emphysema and bronchitis) is discussed in Anderson and Shinagawa, 1999, Current Opinion in Anti-inflammatory and Immunomodulatory Investigational Drugs 1(1): 29-38.
  • R , R , R , R , R , R and R are broadly defined.
  • the derivatives are said, in general terms, to act as inhibitors of metalloproteinases, in particular TACE, MMPs and/or aggrecanase, although no data demonstrating biological activity is included in the application.
  • X represents an oxygen atom or a group NR ' or CH2;
  • Y represents NH or N-methyl
  • Either R represents hydrogen or a group selected from -Cg alkyl and a saturated or unsaturated 3- to 10-membered ring system which may comprise at least one ring heteroatom selected from nitrogen, oxygen and sulphur, each group being optionally substituted with at least one substituent selected from halogen, hydroxyl, cyano, carboxyl, -NR R , -CONR R , C ⁇ -C 6 alkyl, -C6 alkoxy, - alkylcarbonyl(oxy), -S(O) m C ⁇ -C6 alkyl where m is 0, 1 or 2, Ci-Cg alkylsulphonylamino, Ci-Cg alkoxycarbonyl(amino), benzyloxy and a saturated or unsaturated 5- to 6- membered ring which may comprise at least one ring heteroatom selected from nitrogen, oxygen and sulphur, the ring in turn being optionally substituted with at least one substituent selected from halogen, hydroxyl, oxo
  • Ci-Cg alkoxycarbonyl and C ⁇ -Cg hydroxyalkyl Ci-Cg alkoxycarbonyl and C ⁇ -Cg hydroxyalkyl
  • R represents hydrogen or Cj-Cg alkyl
  • R represents hydrogen or C -Cs alkyl
  • 5- to 6-membered ring optionally comprising a ring heteroatom selected from nitrogen,
  • 5- to 6-membered ring optionally comprising a ring heteroatom selected from nitrogen, oxygen and sulphur, and R is as defined above;
  • R represents hydrogen or -Cg alkyl
  • f-i ⁇ R R , R , R and R each independently represent hydrogen or -Cg alkyl optionally substituted by at least one substituent selected from hydroxyl, halogen and Ci-Cg alkoxy;
  • L represents -CH 2 C(O)- or -C(O)CH 2 -, or
  • L represents a C2-C6 alkyl or C2-Cg alkynyl group optionally interrupted or terminated by at least one moiety selected from O, NH, S, SO, SO2 and C(O), or L represents a C3-C6 cycloalkyl, methylC3-C6 cycloalkyl or C3-C6 cycloalkylmethyl group, each of the recited groups being optionally substituted with at least one substituent selected from hydroxyl, halogen, C1-C4 alkyl, C1-C4 haloalkyl, -C4 alkoxy and
  • L represents a C3-C4 alkylene chain, the ends of which are attached to adjacent ring
  • 2 G represents a saturated or unsaturated 5- to 10-membered ring system which may comprise at least one ring heteroatom selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted with at least one substituent selected from halogen, hydroxyl, cyano, nitro, Cj-Cg alkyl (optionally substituted by one or more of cyano, halogen, hydroxyl and methoxy), C2-C6 alkenyl, alkoxy (optionally substituted by one or more halogen atoms), -S(O) n C ⁇ -C6 alkyl where n is 0, 1 or 2,
  • R alkyl optionally substituted by at least one substituent selected from hydroxyl, halogen and C j -C ⁇ alkoxy;
  • M represents a bond or -O-, -S-, -C ⁇ C-, -CH2O- or -OCH 2 -;
  • 3 G represents an unsaturated 5- to 10-membered ring system which may comprise at least one ring heteroatom selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted with at least one substituent selected from halogen, hydroxyl, cyano, nitro, Ci-Cg alkyl (optionally substituted by one or more of cyano, halogen, hydroxyl and methoxy), C2-Cg alkenyl, C ⁇ -Cg alkoxy (optionally substituted by one or more halogen atoms), -S(O)tC ⁇ -C6 alkyl where t is 0, 1 or 2,
  • R and R each independently represent hydrogen or Cj-Cg alkyl optionally substituted by at least one substituent selected from hydroxyl, halogen and Ci-Cg alkoxy.
  • an alkyl, alkenyl or alkynyl substituent group or an alkyl moiety in a substituent group may be linear or branched.
  • a haloalkyl or haloalkoxy substituent group will comprise at least one halogen atom, e.g. one, two, three or four halogen atoms.
  • a hydroxyalkyl substituent may contain one or more hydroxyl groups but preferably contains one or two hydroxyl groups.
  • R and R form a ring
  • the ring may comprise up to one ring heteroatom only.
  • R it should be noted that each of the saturated or unsaturated 3- to 10-membered ring system and the saturated or unsaturated 5- to 6-membered ring may have alicyclic or aromatic properties. The same comment applies
  • An unsaturated ring system will be partially or fully unsaturated.
  • L represents a
  • C2-C6 alkyl or C2-Cg alkynyl group optionally interrupted or terminated by more than one moiety (e.g. two moieties) selected from O, NH, S, SO, SO2 and C(O), it may in some instances be possible for the two moieties to be adjacent to one another but otherwise the moieties will need to be separated by one or more carbon atoms.
  • moieties selected from O, NH, S, SO, SO2 and C(O)
  • X represents an oxygen atom or a group NR where R represents hydrogen or Ci-C ⁇ , preferably C1-C4, alkyl (e.g. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl or n-hexyl).
  • R represents hydrogen or Ci-C ⁇ , preferably C1-C4, alkyl (e.g. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl or n-hexyl).
  • X represents NH or N-methyl. In a further embodiment, X represents NH.
  • Z and Z both represent an oxygen atom.
  • R represents hydrogen or a group selected from preferably C1-C4, alkyl (e.g. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl or n-hexyl) and a saturated or unsaturated 3- to 10-membered ring system which may comprise at least one ring heteroatom (e.g. one, two, three or four ring heteroatoms independently) selected from nitrogen, oxygen and sulphur, each group being optionally substituted with at least one substituent (e.g. one, two, three or four substituents independently) selected from halogen (e.g.
  • Ci-Cg methylcarbonyl(oxy), ethylcarbonyl(oxy), n-propylcarbonyl(oxy), isopropylcarbonyl(oxy), n-butylcarbonyl(oxy), n-pentylcarbonyl(oxy) or n-hexylcarbonyl(oxy)), -S(O) m Ci-Cg, preferably -C4, alkyl where m is 0, 1 or 2 (e.g.
  • Ci-Cg preferably C1-C4, alkylsulphonylamino (e.g.
  • Cj-Cg preferably C1-C4, alkyl (e.g. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl or n-hexyl), Cj-Cg, preferably C1-C4, alkoxycarbonyl (e.g. methoxycarbonyl or ethoxycarbonyl) and C -Cg, preferably
  • hydroxyalkyl e.g. -CH 2 OH, -CH 2 CH 2 OH, -CH 2 CH2CH 2 OH or -CH(OH)CH 3 );
  • R represents hydrogen or CJ-CO, preferably C1-C4, alkyl (e.g. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl or n-hexyl); and
  • saturated or unsaturated 3- to 10-membered ring systems that may be used, which may be monocyclic or polycyclic (e.g. bicyclic) in which the two or more rings are fused, include one or more (in any combination) of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[2.2.1]heptyl, cyclopentenyl, cyclohexenyl, phenyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, diazabicyclo[2.2.1]hept-2-yl, naphthyl, benzofuranyl, benzothienyl, benzodioxolyl, quinolinyl,
  • Preferred ring systems include phenyl, pyridinyl and tetrahydropyranyl.
  • saturated or unsaturated 5- to 6-membered ring substituents in R include cyclopentyl, cyclohexyl, phenyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, tetrahydropyranyl, thiomorpholinyl, pyrazolyl, pyrazinyl, pyridazinyl, thiazolidinyl, thienyl, isoxazolyl, pyrimidinyl, thiadiazolyl, pyrrolyl, furanyl, thiazolyl, imidazolyl, triazolyl, tetrazolyl and pyridinyl.
  • Preferred rings include morpholinyl, pyrimidinyl, phenyl, imidazolyl, piperidinyl, tetrahydropyranyl and triazolyl.
  • R Particular values for R include the following
  • R represents hydrogen or a group selected from C1-C4 alkyl and a saturated or unsaturated 5- to 10-membered ring system which may comprise at least one ring heteroatom (e.g. one, two, three or four ring heteroatoms independently) selected from nitrogen, oxygen and sulphur, each group being optionally substituted with at least one substituent (e.g.
  • substituents independently selected from halogen, hydroxyl, cyano, carboxyl, -NR R , -CONR R , C1-C4 alkyl, -C4 alkoxy, -C4 alkylcarbonyl(oxy), -S(O) m C ⁇ -C4 alkyl where m is 0, l or 2, C1-C4 alkylsulphonylamino, C1-C4 alkoxycarbonyl(amino), benzyloxy and a saturated or unsaturated 5- to 6-membered ring which may comprise at least one ring heteroatom (e.g.
  • substituent e.g. one, two or three substituents independently
  • R represents hydrogen or C1-C4 alkyl
  • R represents hydrogen or C 1-C4 alkyl.
  • R represents hydrogen or C1-C4 alkyl, particularly methyl
  • R represents hydrogen; and R represents hydrogen.
  • R and R may together with the carbon atoms to which they are attached form a saturated 5- to 6-membered ring optionally comprising a ring heteroatom selected from nitrogen, oxygen and sulphur (e.g. cyclopentyl, cyclohexyl, pyrrolidinyl, piperidinyl,
  • R and R may together with the carbon atom to which they are attached form a saturated 5- to 6-membered ring optionally comprising a ring heteroatom selected from nitrogen, oxygen and sulphur (e.g. cyclopentyl, cyclohexyl, pyrrolidinyl, piperidinyl, tetrahydrofuranyl or tetrahydrothiophenyl), and R is as previously defined. 5 6 7 8
  • R , R , R and R each independently represent hydrogen or -Cg, preferably
  • alkyl e.g. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl or n-hexyl
  • substituent e.g. one, two or three substituents independently
  • halogen e.g. chlorine, fluorine, bromine or iodine
  • C1-C6 preferably C ⁇ -C4, alkoxy (e.g. methoxy, ethoxy, n-propoxy or n-butoxy).
  • R , R , R and R each independently represent hydrogen or Ci-C ⁇ , preferably -C4, alkyl. In another embodiment, R , R , R and R each independently represent hydrogen.
  • L represents -CH 2 C(O)- or -C(O)CH 2 -, or
  • L represents a C 2 -C6, preferably C2-C4, alkyl or C2-Cg, preferably C2-C4, alkynyl group optionally interrupted or terminated by at least one moiety (e.g. one or two moieties independently) selected from O, NH, S, SO, SO2 and C(O) (for example, -(CH 2 ) 2 -, -(CH 2 ) 3 -, -(CH 2 ) 4 -, -(CH 2 ) 5 -, -(CH 2 )6-, "C ⁇ C-, -CH 2 -C ⁇ C-, -C ⁇ C-CH 2 -, -O-(CH 2 ) 3 -NH-, -NH-(CH 2 ) 3 -O-, -CH(CH 3 K -(CH 2 ) 2 -C(O)-, -C(O)-(CH 2 ) 2 -, -CH 2 CH(CH 3 )-, -CH(CH 3
  • methylcyclopropyl or C3-C6 cycloalkylmethyl (e.g. cyclopropylmethyl) group, each of the recited groups being optionally substituted with at least one substituent (e.g. one, two or three substituents independently) selected from hydroxyl, halogen (e.g. chlorine, fluorine, bromine or iodine), -C4, preferably C ⁇ -C 2 , alkyl (e.g. methyl, ethyl, n-propyl, isopropyl, n-butyl or t-butyl), C1-C4, preferably C ⁇ C 2 , haloalkyl (e.g.
  • trifluoromethoxy such as -CH 2 OCH(R)CH 2 NH- or -NHCH 2 CH( )OCH 2 - where R represents methyl, hydroxyl or methoxy, -CH(CH 3 )-CH(OH)-, -CH(OH)-CH(CH 3 )-, -CH 2 CH(OH)-, -CH(OH)CH 2 -, -CH 2 CH(OCH 3 )- or -CH(OCH 3 )CH 2 -), or
  • L represents a C3-C4 alkylene chain, the ends of which are attached to adjacent ring carbon
  • L represents -C(O)CH2-
  • L represents C2-C4 alkyl optionally interrupted or terminated by an oxygen atom, cyclopropyl or cyclopropylmethyl, each of which is optionally substituted with one or two substituents independently selected from hydroxyl, halogen, methyl, trifluoromethyl, methoxy and trifluoromethoxy, or L represents a C3-C4 alkylene chain, the ends of which are attached to adjacent ring carbon
  • L represents (reading from left to right in formula (I)) -C(O)CH 2 -, -(CH 2 ) 2 -, -CH(CH 3 )-, -CH(CH 3 )CH 2 -, -CH(OH)-CH(CH 3 )-, -CH(OH)CH 2 -, -CH(OCH 3 )CH 2 -, -CH 2 -O-(CH 2 )2, cyclopropyl, cyclopropylmethyl, or
  • L represents a C3 alkylene chain, the ends of which are attached to adjacent ring carbon
  • 2 G represents a saturated or unsaturated 5- to 10-membered ring system which may comprise at least one ring heteroatom (e.g. one, two, three or four ring heteroatoms independently) selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted with at least one substituent (e.g. one, two, three or four substituents independently) selected from halogen (e.g.
  • Ci-Cg preferably C1-C4, alkyl such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl or n-hexyl (optionally substituted by one or more, e.g. one, two or three, substituents independently selected from cyano, halogen such as chlorine, fluorine, bromine or iodine, hydroxyl and methoxy), C2-Cg, preferably C2-C4, alkenyl (e.g.
  • ethenyl prop-1-enyl, prop-2-enyl, but-1-enyl, pent-1-enyl, hex-1-enyl or 2-methyl-pent-2-enyl
  • Cj-Cg preferably C1-C4, alkoxy such as methoxy, ethoxy, n- propoxy or n-butoxy (optionally substituted by one or more, e.g. one, two or three, halogen atoms such as chlorine, fluorine, bromine or iodine), -S(O) n C ⁇ -C6, preferably C1-C4, alkyl where n is 0, 1 or 2 (e.g.
  • Ci-Cg preferably C1-C4, alkylcarbonyl(amino) (e.g.
  • 2 G which may be monocyclic or polycyclic (e.g. bicyclic) in which the two or more rings are fused, include one or more (in any combination) of cyclopentyl, cyclohexyl, bicyclo[2.2.1]heptyl, cyclopentenyl, cyclohexenyl, phenyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, diazabicyclo[2.2.1]hept-2-yl, naphthyl, benzofuranyl, benzothienyl, benzodioxolyl, quinolinyl, 2,3-dihydrobenzofuranyl, tetrahydropyranyl, pyrazolyl, pyrazinyl, thiazolidinyl, indanyl, thienyl, isoxazolyl*, pyridazinyl, thiadiazolyl
  • R and R each independently represent hydrogen or Ci-Cg, preferably C1-C4, alkyl (e.g. methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-pentyl or n-hexyl) optionally substituted by at least one substituent (e.g. one, two or three substituents independently) selected from hydroxyl, halogen (e.g. chlorine, fluorine, bromine or iodine) and Ci-Cg, preferably C1-C4, alkoxy (e.g. methoxy, ethoxy, n-propoxy or n-butoxy).
  • substituent e.g. one, two or three substituents independently
  • Ci-Cg preferably C1-C4, alkoxy (e.g. methoxy, ethoxy, n-propoxy or n-butoxy).
  • G represents a saturated or unsaturated 5- to 9- membered ring system which may comprise one ring heteroatom selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted with one or two substituents independently selected from halogen, hydroxyl, cyano, nitro, C1-C4 alkyl (optionally substituted by one or more, e.g. one, two or three, substituents independently selected from cyano, halogen such as chlorine, fluorine, bromine or iodine, hydroxyl and methoxy), C 2 -C4 alkenyl, C1-C4 alkoxy (optionally substituted by one or more, e.g. one, two or three, halogen atoms such as chlorine, fluorine, bromine or iodine),
  • n 0, 1 or 2
  • G represents a saturated or unsaturated 5- to 9-membered ring system which may comprise one ring heteroatom selected from nitrogen and sulphur (e.g. phenyl, indolyl, thienyl or piperidinyl), the ring system being optionally substituted with one or two substituents independently selected from halogen, C1-C4 alkyl and a group of formula
  • M represents a bond, -O- or -C ⁇ C-. In a further embodiment, M represents a bond.
  • 3 G represents an unsaturated 5- to 10-membered ring system which may comprise at least one ring heteroatom (e.g. one, two, three or four ring heteroatoms independently) selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted with at least one substituent (e.g. one, two, three or four substituents independently) selected from halogen (e.g.
  • Ci-C preferably C1-C4, alkyl such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert- butyl, n-pentyl or n-hexyl (optionally substituted by one or more, e.g. one, two or three, substituents independently selected from cyano, halogen such as chlorine, fluorine, bromine or iodine, hydroxyl and methoxy), C 2 -Cg, preferably C 2 -C4, alkenyl (e.g.
  • ethenyl prop-1-enyl, prop-2-enyl, but-1-enyl, pent-1-enyl, hex-1-enyl or 2-methyl- pent-2-enyl
  • C1-C5, preferably -C4, alkoxy such as methoxy, ethoxy, n-propoxy or n-butoxy (optionally substituted by one or more, e.g. one, two or three, halogen atoms such as chlorine, fluorine, bromine or iodine), -S(O) t C ⁇ -C6, preferably -C4, alkyl where t is 0, 1 or 2 (e.g.
  • Cj-Cg preferably C1-C4, alkylcarbonyloxy (e.g.
  • G methylcarbonyloxy, ethylcarbonyloxy, n-propylcarbonyloxy, isopropylcarbonyloxy, n-butylcarbonyloxy, n-pentylcarbonyloxy or n-hexylcarbonyloxy), phenyl, benzyloxy and -NR R . 3
  • unsaturated 5- to 10-membered ring systems that may be used in G , which may be monocyclic or polycyclic (e.g.
  • bicyclic in which the two or more rings are fused, include one or more (in any combination) of cyclopentenyl, cyclohexenyl, phenyl, naphthyl, benzofuranyl, benzothienyl, benzodioxolyl, quinolinyl, 2,3- dihydrobenzofuranyl, pyrazolyl, pyrazinyl, thiazolidinyl, indanyl, thienyl, isoxazolyl, pyridazinyl, thiadiazolyl, pyrrolyl, furanyl, thiazolyl, indolyl, imidazolyl, pyrimidinyl, benzimidazolyl, triazolyl, tetrazolyl and pyridinyl.
  • Preferred ring systems include phenyl, thienyl, naphthyl, benzofuranyl, benzothienyl, pyridinyl, pyrrolyl, furanyl, benzodioxolyl, quinolinyl and 2,3-dihydrobenzofuranyl.
  • R and R each independently represent hydrogen or Ci-C , preferably C1-C4, alkyl
  • substituent e.g. one, two or three substituents independently
  • substituent e.g. one, two or three substituents independently
  • hydroxyl e.g. halogen (e.g. chlorine, fluorine, bromine or iodine) and Ci-Cg, preferably -C4, alkoxy (e.g. methoxy, ethoxy, n-propoxy or n-butoxy).
  • G represents an unsaturated 5- to 10-membered ring system which may comprise one or two ring heteroatoms independently selected from nitrogen, oxygen and sulphur (e.g. phenyl, thienyl, naphthyl, benzofuranyl, benzothienyl, pyridinyl, pyrrolyl, furanyl, benzodioxolyl, quinolinyl and 2,3-dihydrobenzofuranyl), the ring system being optionally substituted with one or two substituents independently selected from halogen, hydroxyl, cyano, nitro, C1-C4 alkyl (optionally substituted by one or more, e.g. one, two or three, substituents independently selected from cyano, halogen such as chlorine, fluorine, bromine or iodine, hydroxyl and methoxy), C 2 -C4 alkenyl, C1-C4 alkoxy
  • halogen atoms such as chlorine, fluorine, bromine or iodine
  • -S(O)tC ⁇ -C4 alkyl where t is 0, 1 or 2
  • G represents an unsaturated 5- to 10-membered ring system which may comprise one or two ring heteroatoms independently selected from nitrogen, oxygen and sulphur (e.g.
  • G represents an unsaturated 5- to 10-membered ring system which may comprise one or two ring heteroatoms independently selected from nitrogen, oxygen and sulphur (e.g. phenyl, thienyl, naphthyl, benzofuranyl, benzothienyl, pyridinyl, pyrrolyl, furanyl, benzodioxolyl, quinolinyl and 2,3-dihydrobenzofuranyl), the ring system being optionally substituted with one or two substituents independently selected from fluorine, chlorine, cyano, nitro, methyl, cyanomethyl, trifluoromethyl, methoxy, trifluoromethoxy, methylthio, methylcarbonyl (acetyl), methylcarbonylamino
  • nitrogen, oxygen and sulphur e.g. phenyl, thienyl, naphthyl, benzofuranyl, benzothienyl, pyridinyl, pyrroly
  • X represents -NH- or -N(CH 3 )-;
  • Y represents NH
  • R represents hydrogen or methyl
  • R represents hydrogen;
  • L represents -C(O)CH 2 -, -(CH 2 )2", -CH(CH 3 )-, -CH(CH 3 )CH 2 -, -CH(OH)-CH(CH 3 )-, -CH(OH)CH 2 -, -CH(OCH 3 )CH 2 -, -CH 2 -O-(CH 2 ) 2 , cyclopropyl, cyclopropylmethyl, or
  • L represents a C3 alkylene chain, the ends of which are attached to adjacent ring
  • 2 G represents represents a saturated or unsaturated 5- to 9-membered ring system which may comprise one ring heteroatom selected from nitrogen and sulphur, the ring system being optionally substituted with one or two substituents independently selected from halogen, C1-C4 alkyl and a group of formula
  • M represents a bond, -O- or -C ⁇ C-
  • 3 G represents an unsaturated 5- to 10-membered ring system which may comprise one or two ring heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted with one or two substituents independently selected from fluorine, chlorine, cyano, nitro, methyl, cyanomethyl, trifluoromethyl, methoxy, trifluoromethoxy, methylthio, methylcarbonyl, methylcarbonylamino, phenyl and benzyloxy.
  • Examples of compounds of the invention include: 2-(2,5-Dioxoimidazolidin-4-yl)-N-[2-(4'-fluoro-biphenyl-4-yl)-ethyl]-acetamide,
  • each exemplified compound represents a particular and independent aspect of the invention.
  • the compounds according to the invention may contain one or more asymmetrically substituted carbon atoms.
  • the presence of one or more of these asymmetric centres (chiral centres) in compounds according to the invention can give rise to stereoisomers, and in each case the invention is to be understood to extend to all such stereoisomers, including enantiomers and diastereomers, and mixtures including racemic mixtures thereof.
  • Racemates may be separated into individual optically active forms using known procedures (cf. Advanced Organic Chemistry: 3rd Edition: author J March, pi 04- 107) including for example the formation of diastereomeric derivatives having convenient optically active auxiliary species followed by separation and then cleavage of the auxiliary species.
  • optically active centres exist in the compounds of the invention, we disclose all individual optically active forms and combinations of these as individual specific embodiments of the invention, as well as their corresponding racemates.
  • the compounds of the invention may be provided as pharmaceutically acceptable salts or solvates.
  • These include acid addition salts such as hydrochloride, hydrobromide, citrate, tosylate and maleate salts and salts formed with phosphoric and sulphuric acid.
  • suitable salts are base salts such as an alkali metal salt for example sodium or potassium, an alkaline earth metal salt for example calcium or magnesium, or organic amine salt for example triethylamine.
  • suitable salts include hydrates.
  • the compounds of formula (I) have activity as pharmaceuticals.
  • the compounds of the invention are metalloproteinase inhibitors, in particular they are inhibitors of MMP12 and may be used in the treatment of diseases or conditions mediated by MMP12 such as asthma, rhinitis, chronic obstructive pulmonary diseases (COPD), arthritis (such as rheumatoid arthritis and osteoarthritis), atherosclerosis and restenosis, cancer, invasion and metastasis, diseases involving tissue destruction, loosening of hip joint replacements, periodontal disease, fibrotic disease, infarction and heart disease, liver and renal fibrosis, endometriosis, diseases related to the weakening of the extracellular matrix, heart failure, aortic aneurysms, CNS related diseases such as Alzheimer's disease and Multiple Sclerosis (MS), and hematological disorders.
  • MMP12 chronic obstructive pulmonary diseases
  • COPD chronic obstructive pulmonary diseases
  • arthritis such as rheumato
  • the compounds of the invention show a favourable selectivity profile. Whilst we do not wish to be bound by theoretical considerations, the compounds of the invention are believed to show selective inhibition for any one of the above indications relative to any MMPl inhibitory activity, by way of non-limiting example they may show 100-1000 fold selectivity over any MMPl inhibitory activity.
  • the present invention provides a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, as hereinbefore defined for use in therapy.
  • the invention provides the use of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, as hereinbefore defined in the manufacture of a medicament for use in therapy.
  • the term “therapy” also includes “prophylaxis” unless there are specific indications to the contrary.
  • the terms “therapeutic” and “therapeutically” should be construed accordingly.
  • the invention further provides a method of treating a disease or condition mediated by MMP 12 which comprises administering to a patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof as hereinbefore defined.
  • the invention also provides a method of treating an obstructive airways disease (e.g. asthma or COPD) which comprises administering to a patient a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof as hereinbefore defined.
  • an obstructive airways disease e.g. asthma or COPD
  • the dosage administered will, of course, vary with the compound employed, the mode of administration, the treatment desired and the disorder indicated.
  • the daily dosage of the compound of formula (I)/salt/solvate (active ingredient) may be in the range from 0.001 mg/kg to 75 mg/kg, in particular from 0.5 mg/kg to 30 mg/kg. This daily dose may be given in divided doses as necessary.
  • unit dosage forms will contain about 1 mg to 500 mg of a compound of this invention.
  • the compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof may be used on their own but will generally be administered in the form of a pharmaceutical composition in which the formula (I) compound/salt/solvate (active ingredient) is in association with a pharmaceutically acceptable adjuvant, diluent or carrier.
  • the pharmaceutical composition will preferably comprise from 0.05 to 99 w (per cent by weight), more preferably from 0.10 to 70 w, of active ingredient, and, from 1 to 99.95 %w, more preferably from 30 to 99.90 %w, of a pharmaceutically acceptable adjuvant, diluent or carrier, all percentages by weight being based on total composition.
  • the present invention also provides a pharmaceutical composition
  • a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof as hereinbefore defined in association with a pharmaceutically acceptable adjuvant, diluent or carrier.
  • the invention further provides a process for the preparation of a pharmaceutical composition of the invention which comprises mixing a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof as hereinbefore defined with a pharmaceutically acceptable adjuvant, diluent or carrier.
  • compositions of this invention may be administered in standard manner for the disease or condition that it is desired to treat, for example by oral, topical, parenteral, buccal, nasal, vaginal or rectal adminstration or by inhalation.
  • the compounds of this invention may be formulated by means known in the art into the form of, for example, tablets, capsules, aqueous or oily solutions, suspensions, emulsions, creams, ointments, gels, nasal sprays, suppositories, finely divided powders or aerosols for inhalation, and for parenteral use (including intravenous, intramuscular or infusion) sterile aqueous or oily solutions or suspensions or sterile emulsions.
  • composition of this invention may also contain, or be co-administered (simultaneously or sequentially) with, one or more pharmacological agents of value in treating one or more diseases or conditions referred to hereinabove such as "Symbicort" (trade mark) product.
  • the present invention further provides a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof as defined above which comprises,
  • Hal represents a halogen atom such as chlorine or bromine and L and G are as defined in formula (I); or
  • LG represents a leaving group such as halogen or sulphonate (e.g.
  • L and G are as defined in formula (I), in the presence of a strong base (e.g. sodium hydride or lithium diisopropylamide); and optionally after (a), (b) or (c) forming a pharmaceutically acceptable salt or solvate.
  • a strong base e.g. sodium hydride or lithium diisopropylamide
  • reaction between the compounds of formulae (III) and (IV) represents a simple amide or ester coupling well known to those skilled in the art.
  • the carboxylic acid of formula (IV) must be activated in some way, for example as the acid halide, anhydride, acyl urea or acyl derivative of N-hydroxysuccinimide.
  • amides and esters see, for example, Carey, F.A. and Sundberg, J., Advanced Organic Chemistry, 3rd Edition, pp 144-152, 1990.
  • PEG polyethylene glycol
  • the BOC-protected amine was dissolved in a mixture of lOmL toluene, 2.5mL ethanol and 2.5mL 2M Na 2 CO 3 /aq.
  • PdCl 2 (dppf) (0.03eq, 50mg) was added together with a corresponding boronic acid (1.05eq, 2.1mmol).
  • the s.olution was degassed with nitrogen and the vessel was sealed before it was stirred overnight at 80°C.
  • the reaction mixture was diluted with 50mL toluene and 50mL water. After mixing, the organic layer was transferred directly on to a silica column and purified by chromatography (toluene- ethylacetate).
  • Example 36 N. ⁇ [l-(4-Chlorophenyl)cyclopropyl]methyl ⁇ -2-(2,5-dioxoimidazolidin-4-yl)acetamide 1H NMR (400MHz,DMSO-d 6 ): ⁇ 10.53(1H, d); 7.95 (IH, t); 7.73 (IH, s); 7.33-7.25 (4H, m); 4.18-4.15 (IH, m); 3.39-3.22 (2H, m); 2.54-2.37 (2H, m); 0.90-0.88 (2H, m); 0.76- 0.73 (2H, m) APCI-MS m/z: 322.3 [MH + ]
  • Example 62 2-(2,5-Dioxoimidazolidin-4-yl)-N- ⁇ 2-[3'-(methylthio)biphenyl-4-yl]propyl ⁇ -acetamide APCI-MS m/z: 398.4 [MH + ]
  • Example 63 2-(2,5-Dioxoimidazolidin-4-yl)-N- ⁇ 2-[3'-(methylthio)biphenyl-4-yl]propyl ⁇ -acetamide APCI-MS m/z: 398.4 [MH + ]
  • Example 63 2-(2,5-Dioxoimidazolidin-4-yl)-N- ⁇ 2-[3'-(methylthio)biphenyl-4-yl]propyl ⁇ -acetamide APCI-MS m/z: 398.4 [MH + ]
  • the BOC-group was removed by stirring the compound obtained in b) above in hydrochloric acid/THF (0.5mL cone. HC1 /1.5mL THF) for 2 hours at room temperature before it was made basic by adding 10.5mL 1M NaOH/aq.
  • the free amine was extracted with 3xl0mL dichloromethane that was dried over Na 2 SO 4 , filtrated and evaporated to dryness. Yield 0.32 mmol (62%).
  • Triethylamine was evaporated and the mixture was purified by silica gel chromatography (75 mL) using heptane/ethyl acetate (4 + 1) as eluant. Evaporation of pure fractions gave 0.497 g (73 %) of N-BOC-4- (phenylethynyl)piperidine.
  • the protected piperidine, 0.497 g (1.74 mmol) was dissolved in dichloromethane and trifluoroacetic acid (1 mL) was added. The reaction was completed within 20 hours and the mixture was evaporated to give an oil.
  • NMR analysis showed pure ammonium trifluoroacetate, contaminated with trifluoroacetic acid.
  • Hydantoin acetic acid 109 mg, 0.69 mmol
  • 2-bromo-4'-phenylacetophenone (191 mg, 0.69 mmol)
  • N-ethyl-diisopropylamine 120 ⁇ l, 0.70 mmol
  • Evaporation and chromatography on silica afforded 123 mg of the title compound in 50.1 % yield.
  • Recombinant human MMP 12 catalytic domain may be expressed and purified as described by Parkar A.A. et al, (2000), Protein Expression and Purification, 20: 152.
  • the purified enzyme can be used to monitor inhibitors of activity as follows: MMP12 (50 ng/ml final concentration) is incubated for 60 minutes at room temperature with the synthetic substrate Mac-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH 2 in assay buffer (0.1M "Tris-HCl” (trade mark) buffer, pH 7.3 containing 0.1M NaCl, 20mM CaCl 2 , 0.020 mM ZnCl and 0.05% (w/v) "Brij 35" (trade mark) detergent) in the presence (5 concentrations) or absence of inhibitors.
  • assay buffer 0.1M "Tris-HCl” (trade mark) buffer, pH 7.3 containing 0.1M NaCl, 20mM CaCl 2 , 0.020 mM ZnCl and
  • % Inhibition is equal to the [Fluorescence ⁇ inhibitor - Fluo ⁇ &scence background ] divided by the [rluorescence r ⁇ ' WH j inhibitor ⁇ ⁇ l ⁇ ° ⁇ CQ ⁇ CQ backgroundl •
  • the following table shows the IC 50 figures for a representative selection of compounds according to the invention when tested in the MMP12 enzyme assay.

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PCT/SE2003/001328 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12. WO2004020415A1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
UAA200501189A UA81635C2 (en) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12.
HK05109053.0A HK1077061B (en) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12
DE60310582T DE60310582T2 (de) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-ylacetamide und analoga als inhibitoren von metalloproteinase mmp12
AU2003253557A AU2003253557B2 (en) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase MMP12
CA002495853A CA2495853A1 (en) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12
JP2004532506A JP2006503019A (ja) 2002-08-27 2003-08-26 メタロプロテイナーゼｍｍｐ１２のインヒビターとしての２，５−ジオキソイミダゾリジン−４−イルアセトアミドおよび類似体
US10/525,640 US7354940B2 (en) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-yl acetamines and analogues as inhibitors of metalloproteinase mmp12
MXPA05002066A MXPA05002066A (es) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-il acetamidas y analogos como inhibidores de la metaloproteinasa mmp12.
SI200330661T SI1542977T1 (sl) 2002-08-27 2003-08-26 2,5-dioksoimidazolidin-4-il acetamidi in analogi kot inhibitorji metaloproteinaze MMP12
NZ538443A NZ538443A (en) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase MMP12
DK03791528T DK1542977T3 (da) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-ylacetamider og analoger som inhibitorer af metalloproteinase MMP12
BR0313635-3A BR0313635A (pt) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-5-il acetamidas e análogos como inibidores da metaloproteinase mmp12
EP03791528A EP1542977B1 (en) 2002-08-27 2003-08-26 2,5-dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12.
IL166826A IL166826A (en) 2002-08-27 2005-02-10 2,5 - dioxoimidazolidin-4-yl acetamides and analogues as inhibitors of metalloproteinase mmp12
IS7767A IS2415B (is) 2002-08-27 2005-03-22 2,5-díoxóimídasólídín-4-ýl asetamíð og hliðstæð efni sem tálmar málmpróteinasa MMP12
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US7662845B2 (en) 2010-02-16
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