WO2003072094A1 - Ambroxol für die behandlung von schmerzhaften zuständen im mund und rachenraum - Google Patents
Ambroxol für die behandlung von schmerzhaften zuständen im mund und rachenraum Download PDFInfo
- Publication number
- WO2003072094A1 WO2003072094A1 PCT/EP2003/001886 EP0301886W WO03072094A1 WO 2003072094 A1 WO2003072094 A1 WO 2003072094A1 EP 0301886 W EP0301886 W EP 0301886W WO 03072094 A1 WO03072094 A1 WO 03072094A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ambroxol
- mouth
- pain
- pharmaceutical composition
- throat
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Definitions
- the invention relates to the use of ambroxol and its pharmacologically acceptable salts for the manufacture of a medicament for the treatment of painful conditions in the mouth and throat.
- ambroxol trans-4- (2-amino-3,5-dibromobenzylamino) cyclohexanol
- ambroxol is a known expectorant and mucolytic. It is used in peroral forms such as juices, capsules, tablets, inhalation solutions, drops or lozenges.
- ambroxol in suitable doses or concentrations at local application in addition to a very good compatibility has a very good analgesic effect in the mouth and throat.
- the invention therefore relates to the use of ambroxol or one of its pharmacologically tolerable salts for the manufacture of a medicament for the treatment of pain in the oral and / or pharyngeal cavity, selected from the group consisting of acute sore throats, aphthae, gingivitis, periodontal diseases, prosthesis pressure points, pain after oro-pharyngeal interventions, mucosal lesions in the oropharynx and herpes simplex in the oropharynx, in particular aphthae, gingivitis, periodontal diseases, Denture pressure points, pain after oro-pharyngeal surgery, mucosal lesions in the mouth and throat and herpes simplex in the mouth and throat, particularly preferred for the treatment of acute sore throat.
- Acute sore throat means severe sore throat, for example sore throat with difficulty swallowing or burning in the throat.
- Another object of the invention is a pharmaceutical composition containing ambroxol or one of its pharmacologically acceptable salts and one or more active ingredients selected from the group consisting of
- Antiseptics vitamins, corticoids, antiphlogistics, antivirals, antibiotics,
- Suitable antiseptics are, for example, cetylpyridinium Cl, dequalinium Cl,
- Chlorhexidine digluconate, benzalkonium Cl or ethacridine lactate Suitable vitamins are, for example, dexpanthenol (pantothenic acid) or
- Suitable corticoids are, for example, triamcinolone or prednisolone acetate.
- Suitable antiphlogistics are, for example, benzydamine-Cl or choline-salicylate.
- Suitable antivirals are, for example, acyclovir or idoxuridine.
- Suitable antibiotics are, for example, thyrotricin or bacitracin.
- Suitable antimycotics are, for example, amphotericin B or nystatin.
- a suitable proteolytic enzyme is, for example, lysozyme.
- Suitable essential oils are, for example, peppermint oil, thyme or sage.
- Another object of the invention is a pharmaceutical composition containing ambroxol or one of its pharmacologically acceptable salts and one or more active ingredients selected from the group consisting of lysozyme hydrochloride, dipotassium glycyrrhizinat, ammonium glycyrrhizinat, cetylpyridinium chlorides, chlorpheniramine maleate, noscapine, dequalinium chlorides, dextromethorphan phenolphthalinate , Potassium guaiacol sulfonate, dl-methylephedrine hydrochloride, chlorhexidine hydrochloride, and potassium cresolsulfonate.
- Ambroxol is a metabolite of the secretolytic bromhexine. Both active ingredients represent a very well-tolerated active ingredient combination, which positively influences the dual action of ambroxol.
- Another object of the invention is therefore a pharmaceutical composition consisting of ambroxol, bromhexine or its pharmacologically acceptable salts and pharmaceutical excipients, preferably having an ambroxol: bromhexine ratio in a range from 4: 1 to 6: 1, particularly preferably 5: 1.
- compositions wherein the single dose contains 15 to 50 mg ambroxol, preferably 20 mg ambroxol.
- Another object of the invention is a solid, lutschbare or slowly dissolving dosage form of a pharmaceutical composition containing ambroxol and one or more active ingredients selected from the group consisting of antiseptics, vitamins, corticoids, anti-inflammatory drugs, antibiotics, antimycotics and proteolytic enzymes.
- Another object of the invention is the use of a pharmaceutical composition described above for the preparation of a
- Medicament for the treatment of pain in the mouth or pharynx selected from the group consisting of acute sore throats, aphthae, gingivitis, periodontal diseases, denture pressure points, pain after oropharyngeal interventions, mucosal lesions in the oropharyngeal area, and herpes simplex im Oral and pharyngeal area, particularly preferred for the treatment of acute sore throat.
- Another object of the invention is the use of a pharmaceutical composition consisting of ambroxol hydrochloride, a flavoring agent, a lubricant, a matrix material, a sweetener and a polyethylene glycol for the manufacture of a medicament for the treatment of pain in the mouth or / and pharynx selected from the group from acute sore throat, aphthous ulcers, gingivitis, periodontal disease, prosthesis pressure sores, pain after oro-pharyngeal surgery, mucosal Lesions in the oropharynx, and herpes simplex in the oropharynx, particularly preferred for the treatment of acute sore throat.
- Suitable flavorings are, for example, peppermint, eucalyptus or lemon, preferably peppermint flavor.
- Suitable matrix materials are, for example, calcium carbonate, calcium phosphate or sorbitol, preferably sorbitol.
- Suitable sweeteners are, for example, saccharin, saccharin sodium, cyclamate, glycerol or sugar, preferably saccharin sodium.
- Suitable tablet lubricants are, for example, polyethylene glycols, preferably Macrogol 6000.
- Suitable lubricants are, for example, talcum or magnesium stearate, preferably talcum.
- Another object of the invention is the use of an ambroxol-containing lozenge based on sugar alcohols as a matrix material characterized by a content of a pharmaceutically tolerable phyllosilicate and a polyethylene glycol optionally in addition to other pharmaceutical auxiliaries, flavorings for the preparation of a medicament for the treatment of pain in the Oral and / or pharyngeal cavity selected from the group consisting of acute sore throat, aphthous ulcers, gingivitis, periodontal disease, prosthesis pressure, pain after oro-pharyngeal surgery, mucosal lesions in the oropharynx and herpes simplex in the oropharynx, especially preferred for the treatment of acute sore throat.
- Another object of the invention is the use of ambroxol for the manufacture of a medicament having an analgesic effect over a period of at least 3 hours, preferably over 3 hours, after an application.
- the invention likewise relates to the use of a pharmaceutical composition containing ambroxol for the manufacture of a medicament having an analgesic action over a period of at least 3 hours, preferably over 3 hours, after an application. Preference is given to administering the pharmaceutical composition according to the invention 1 to 6 times, preferably 2 to 4 times daily.
- Suitable acids for sacculating ambroxol are, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, nitric acid, oxalic acid, malonic acid, fumaric acid, maleic acid, tartaric acid, citric acid, ascorbic acid and methanesulfonic acid, preferably hydrochloric acid.
- ambroxol according to the invention is to be illustrated by the following examples of clinical studies examining the efficacy of ambroxol lozenges of different strengths. These serve only to illustrate the invention and are not to be regarded as limiting.
- a multicentre, prospective, placebo-controlled, randomized, double-blind study was conducted over two days of treatment with up to 6 lozenges containing ambroxol hydrochloride per day.
- the intent-to-treat (ITT) population consisted of 208 patients (105 with ambroxol treatment and 103 with appropriate placebo administration); 196 patients formed the per-protocol (PP) population (97 with Verum and 99 with placebo, respectively).
- ITT intent-to-treat
- PP per-protocol
- Double-blind treatment with up to 6 lozenges per day, each containing either 20 mg ambroxol or a placebo (lozenge without the active ingredient, but also with a verum comparable - pronounced taste of peppermint)
- Endpoints the time-weighted average pain reduction during the first 3 hours after administration of the first lozenge, normalized to the degree of baseline pain (SPID norm ); furthermore, the evaluation of efficacy and tolerability by the patient at the end of each treatment day. Results: In both treatment groups, a reduction in pain intensity was observed; the mean SPID norm ( ⁇ SD) after the first one
- Lozenge was 0.39 ⁇ 0.27 for 20 mg ambroxol hydrochloride and 0.28 ⁇ 0.25 for placebo.
- Figure 1 shows the time course of the mean change in pain intensity (PID) for the period before ingestion (baseline) up to 3 hours after ingestion of the first lozenge with 20 mg ambroxol hydrochloride and placebo.
- Double-blind treatment with up to 6 lozenges per day containing either 20 mg or 30 mg ambroxol hydrochloride or a placebo (lozenge without the active substance but also with a pronounced peppermint flavor similar to the verum)
- Endpoints the time-weighted average pain reduction during the first 3 hours after administration of the first lozenge, normalized to the degree of baseline pain (SPID norm ); Furthermore, the assessment of efficacy and tolerability by the patient at the end of each treatment day. Results: All treatments resulted in a reduction of pain intensity, the mean ( ⁇ SD) SPID norm after ingestion of the first lozenge was 0.53
- Ambroxol may be used alone or in combination with other pharmacologically active substances.
- dosage forms all types of preparations that are suitable for local use can be used.
- compresses or candies based on sugar or sugar substitutes are suitable or pasty-like products with a gum arabic or gelatine base.
- Suitable semi-solid preparations for application to the oral mucosa are gels, in particular gels based on cellulose or acrylate.
- Suitable spraying, gargling and rinsing solutions are aqueous preparations, advantageously with the addition of viscosity-increasing substances, such as modified celluloses, acrylic acid derivatives or polyvinyl compounds.
- the semi-solid and liquid forms may contain sweeteners and humectants, for example glycols and sugar alcohols. All forms are usually flavored, e.g. by adding essential oils.
- the dosage forms can be prepared by methods known in the pharmaceutical art.
- Peppermint oil 6.0 mg light anhydrous silicic acid 1.0 mg talc 1.0 mg magnesium stearate 1.5 mg
- Cetylpyridinium chlorides 1.0 mg sucrose (purified) 869.7 mg peppermint flavor 16.0 mg corn starch 30.0 mg polyvinylpyrrolidone 20.0 mg
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Nutrition Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Physiology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002477105A CA2477105A1 (en) | 2002-02-27 | 2003-02-25 | Ambroxol for the treatment of painful conditions in the mouth and pharyngeal cavity |
BR0308038-2A BR0308038A (pt) | 2002-02-27 | 2003-02-25 | Ambroxol para o tratamento de estados doloridos na cavidade bucal e faringe |
KR10-2004-7013393A KR20040084944A (ko) | 2002-02-27 | 2003-02-25 | 구강 및 인두강의 통증 상태 치료용 암브록솔 |
EP03742955A EP1480626A1 (de) | 2002-02-27 | 2003-02-25 | Ambroxol für die behandlung von schmerzhaften zuständen im mund und rachenraum |
AU2003210345A AU2003210345B2 (en) | 2002-02-27 | 2003-02-25 | Ambroxol for treating painful conditions in the mouth and pharyngeal cavity |
JP2003570840A JP2005518435A (ja) | 2002-02-27 | 2003-02-25 | 口腔及び咽頭腔における疼痛状態の治療用アンブロキソール |
MXPA04008220A MXPA04008220A (es) | 2002-02-27 | 2003-02-25 | Ambroxol para tratamiento de estados dolorosos en cavidad bucal y faringea. |
IS7417A IS7417A (is) | 2002-02-27 | 2004-08-19 | Ambroxól til að meðhöndla kvalafullt ástand í munni og koki |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10208313A DE10208313A1 (de) | 2002-02-27 | 2002-02-27 | Ambroxol für die Behandlung von schmerzhaften Zuständen im Mund und Rachenraum |
DE10208313.4 | 2002-02-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003072094A1 true WO2003072094A1 (de) | 2003-09-04 |
Family
ID=27740434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/001886 WO2003072094A1 (de) | 2002-02-27 | 2003-02-25 | Ambroxol für die behandlung von schmerzhaften zuständen im mund und rachenraum |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1480626A1 (de) |
JP (1) | JP2005518435A (de) |
KR (1) | KR20040084944A (de) |
CN (1) | CN1638749A (de) |
AR (1) | AR038698A1 (de) |
AU (1) | AU2003210345B2 (de) |
BR (1) | BR0308038A (de) |
CA (1) | CA2477105A1 (de) |
DE (1) | DE10208313A1 (de) |
EC (1) | ECSP045242A (de) |
IS (1) | IS7417A (de) |
MX (1) | MXPA04008220A (de) |
MY (1) | MY144781A (de) |
PE (1) | PE20030830A1 (de) |
PL (1) | PL371584A1 (de) |
RU (1) | RU2311176C2 (de) |
TW (1) | TW200306804A (de) |
UA (1) | UA86741C2 (de) |
UY (1) | UY27679A1 (de) |
WO (1) | WO2003072094A1 (de) |
ZA (1) | ZA200405635B (de) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005007149A1 (de) * | 2003-07-16 | 2005-01-27 | Boehringer Ingelheim International Gmbh | Ambroxol für die behandlung akuter schmerzen |
JP2005120063A (ja) * | 2003-10-14 | 2005-05-12 | Boehringer Ingelheim Pharma Gmbh & Co Kg | 咽頭における炎症の治療のためのアンブロキソール |
EP1550438A2 (de) * | 2003-12-16 | 2005-07-06 | Advance Holdings Limited | Verfahren zur Herstellung von medizinischen Bonbons enthaltend Ambroxol und so erhaltene Bonbons |
WO2005107732A1 (de) * | 2004-05-03 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Topische zubereitung enthaltend ambroxol |
EP2015761A4 (de) * | 2006-03-29 | 2009-07-29 | Naveh Pharma 1996 Ltd | Verfahren und zusammensetzung zur behandlung von halsentzündung |
US10265280B2 (en) | 2016-11-14 | 2019-04-23 | Mingwu Wang | Formulations for the treatment of ocular surface diseases and related methods |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007084471A (ja) * | 2005-09-21 | 2007-04-05 | Sunstar Inc | 口腔用組成物および口腔用製品の選択方法 |
JP5765934B2 (ja) * | 2009-12-28 | 2015-08-19 | サンスター株式会社 | 口腔用組成物 |
JP6171683B2 (ja) * | 2012-08-03 | 2017-08-02 | 大正製薬株式会社 | 固形製剤 |
CN105769908B (zh) * | 2016-05-06 | 2019-03-01 | 湖北凤凰白云山药业有限公司 | 一种化痰止咳的药物及其制备方法 |
CN106727621A (zh) * | 2016-11-22 | 2017-05-31 | 郑州仁宏医药科技有限公司 | 一种治疗牙痛的西药散剂 |
JP6844394B2 (ja) * | 2017-04-14 | 2021-03-17 | 大正製薬株式会社 | 固形組成物 |
EP3415143A1 (de) * | 2017-06-16 | 2018-12-19 | Kai-Uwe Kern | Bromhexin zur behandlung von schmerz |
Citations (4)
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US5122540A (en) * | 1986-02-28 | 1992-06-16 | W. Keith R. Watson | Method and composition for treating warts and throat soreness with DMSO and citric acid |
EP0896815A1 (de) * | 1996-05-02 | 1999-02-17 | Taisho Pharmaceutical Co. Ltd | Suspension eines wenig wasserloeslichen sauren arzeneistoffes |
WO2001005378A1 (de) * | 1999-07-20 | 2001-01-25 | Boehringer Ingelheim International Gmbh | Ambroxolhaltige lutschtablette |
JP2001151677A (ja) * | 1999-11-26 | 2001-06-05 | Taisho Pharmaceut Co Ltd | 咽頭用組成物 |
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DE3432411A1 (de) * | 1983-09-17 | 1985-04-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Antiadhaesive prohylactica und arzneimittel, enthaltend ein sekretolytisch wirksames benzylaminderivat |
DE3445226A1 (de) * | 1983-12-14 | 1985-08-01 | Reifenrath, Rainer Richard Otto, Dr.med., 7920 Heidenheim | Pharmazeutisches erzeugnis zur behandlung und prophylaxe von infektionen sowie von husten und obstruktiven atemwegserkrankungen |
DE4415553A1 (de) * | 1994-05-03 | 1995-11-09 | Behringwerke Ag | Verwendung von Deoxyspergualin zur Herstellung eines Arzneimittels zur Behandlung von entzündlich-hyperreaktiven Erkrankungen |
DE20102817U1 (de) * | 2000-02-23 | 2001-06-07 | Bolder Arzneimittel Gmbh | Lutsch- und Kaupastillen mit Cyclodextrin |
US6391886B1 (en) * | 2000-12-04 | 2002-05-21 | The Procter & Gamble Company | Oral compositions having improved consumer aesthetics |
-
2002
- 2002-02-27 DE DE10208313A patent/DE10208313A1/de not_active Withdrawn
-
2003
- 2003-02-25 AU AU2003210345A patent/AU2003210345B2/en not_active Ceased
- 2003-02-25 WO PCT/EP2003/001886 patent/WO2003072094A1/de active Application Filing
- 2003-02-25 CA CA002477105A patent/CA2477105A1/en not_active Abandoned
- 2003-02-25 UA UA20040907789A patent/UA86741C2/ru unknown
- 2003-02-25 KR KR10-2004-7013393A patent/KR20040084944A/ko active Search and Examination
- 2003-02-25 PL PL03371584A patent/PL371584A1/xx not_active Application Discontinuation
- 2003-02-25 MY MYPI20030651A patent/MY144781A/en unknown
- 2003-02-25 TW TW092103899A patent/TW200306804A/zh unknown
- 2003-02-25 JP JP2003570840A patent/JP2005518435A/ja active Pending
- 2003-02-25 BR BR0308038-2A patent/BR0308038A/pt not_active Expired - Fee Related
- 2003-02-25 UY UY27679A patent/UY27679A1/es not_active Application Discontinuation
- 2003-02-25 MX MXPA04008220A patent/MXPA04008220A/es not_active Application Discontinuation
- 2003-02-25 EP EP03742955A patent/EP1480626A1/de not_active Ceased
- 2003-02-25 RU RU2004129284/15A patent/RU2311176C2/ru not_active IP Right Cessation
- 2003-02-25 CN CNA038047683A patent/CN1638749A/zh active Pending
- 2003-02-26 AR ARP030100619A patent/AR038698A1/es not_active Suspension/Interruption
- 2003-02-26 PE PE2003000187A patent/PE20030830A1/es not_active Application Discontinuation
-
2004
- 2004-07-15 ZA ZA200405635A patent/ZA200405635B/en unknown
- 2004-08-19 IS IS7417A patent/IS7417A/is unknown
- 2004-08-20 EC EC2004005242A patent/ECSP045242A/es unknown
Patent Citations (4)
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---|---|---|---|---|
US5122540A (en) * | 1986-02-28 | 1992-06-16 | W. Keith R. Watson | Method and composition for treating warts and throat soreness with DMSO and citric acid |
EP0896815A1 (de) * | 1996-05-02 | 1999-02-17 | Taisho Pharmaceutical Co. Ltd | Suspension eines wenig wasserloeslichen sauren arzeneistoffes |
WO2001005378A1 (de) * | 1999-07-20 | 2001-01-25 | Boehringer Ingelheim International Gmbh | Ambroxolhaltige lutschtablette |
JP2001151677A (ja) * | 1999-11-26 | 2001-06-05 | Taisho Pharmaceut Co Ltd | 咽頭用組成物 |
Non-Patent Citations (5)
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2005007149A1 (de) * | 2003-07-16 | 2005-01-27 | Boehringer Ingelheim International Gmbh | Ambroxol für die behandlung akuter schmerzen |
JP2005120063A (ja) * | 2003-10-14 | 2005-05-12 | Boehringer Ingelheim Pharma Gmbh & Co Kg | 咽頭における炎症の治療のためのアンブロキソール |
EP1550438A2 (de) * | 2003-12-16 | 2005-07-06 | Advance Holdings Limited | Verfahren zur Herstellung von medizinischen Bonbons enthaltend Ambroxol und so erhaltene Bonbons |
EP1550438A3 (de) * | 2003-12-16 | 2005-08-10 | Advance Holdings Limited | Verfahren zur Herstellung von medizinischen Bonbons enthaltend Ambroxol und so erhaltene Bonbons |
WO2005107732A1 (de) * | 2004-05-03 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Topische zubereitung enthaltend ambroxol |
JP2007536296A (ja) * | 2004-05-03 | 2007-12-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アンブロキソール含有局所用製剤 |
MD4093B1 (ro) * | 2004-05-03 | 2011-02-28 | Boehringer Ingelheim International Gmbh | Utilizare a compoziţiei farmaceutice topice cu conţinut de ambroxol |
EP2015761A4 (de) * | 2006-03-29 | 2009-07-29 | Naveh Pharma 1996 Ltd | Verfahren und zusammensetzung zur behandlung von halsentzündung |
US10265280B2 (en) | 2016-11-14 | 2019-04-23 | Mingwu Wang | Formulations for the treatment of ocular surface diseases and related methods |
Also Published As
Publication number | Publication date |
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DE10208313A1 (de) | 2003-09-11 |
ZA200405635B (en) | 2005-05-31 |
KR20040084944A (ko) | 2004-10-06 |
BR0308038A (pt) | 2004-12-28 |
JP2005518435A (ja) | 2005-06-23 |
MXPA04008220A (es) | 2004-11-26 |
CN1638749A (zh) | 2005-07-13 |
TW200306804A (en) | 2003-12-01 |
IS7417A (is) | 2004-08-19 |
CA2477105A1 (en) | 2003-09-04 |
AU2003210345B2 (en) | 2009-01-29 |
AU2003210345A1 (en) | 2003-09-09 |
UY27679A1 (es) | 2003-09-30 |
AR038698A1 (es) | 2005-01-26 |
PE20030830A1 (es) | 2003-10-31 |
UA86741C2 (ru) | 2009-05-25 |
ECSP045242A (es) | 2004-09-28 |
RU2311176C2 (ru) | 2007-11-27 |
EP1480626A1 (de) | 2004-12-01 |
MY144781A (en) | 2011-11-15 |
PL371584A1 (en) | 2005-06-27 |
RU2004129284A (ru) | 2005-06-10 |
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