WO2003057733A1 - Anticorps diriges contre le facteur de croissance 23 des fibroblastes - Google Patents

Anticorps diriges contre le facteur de croissance 23 des fibroblastes Download PDF

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Publication number
WO2003057733A1
WO2003057733A1 PCT/JP2003/000017 JP0300017W WO03057733A1 WO 2003057733 A1 WO2003057733 A1 WO 2003057733A1 JP 0300017 W JP0300017 W JP 0300017W WO 03057733 A1 WO03057733 A1 WO 03057733A1
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WIPO (PCT)
Prior art keywords
ferm
acid sequence
amino acid
growth factor
fibroblast growth
Prior art date
Application number
PCT/JP2003/000017
Other languages
English (en)
French (fr)
Inventor
Yuji Yamazaki
Takashi Shimada
Takeyoshi Yamashita
Original Assignee
Kirin Beer Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Beer Kabushiki Kaisha filed Critical Kirin Beer Kabushiki Kaisha
Priority to AU2003202472A priority Critical patent/AU2003202472B2/en
Priority to US10/500,296 priority patent/US7923012B2/en
Priority to KR1020047010142A priority patent/KR101016476B1/ko
Priority to AT03701009T priority patent/ATE441666T1/de
Priority to DE60329070T priority patent/DE60329070D1/de
Priority to EP03701009A priority patent/EP1466925B1/en
Priority to JP2003558047A priority patent/JP4527982B2/ja
Priority to CA2471656A priority patent/CA2471656C/en
Publication of WO2003057733A1 publication Critical patent/WO2003057733A1/ja
Priority to HK05110064.5A priority patent/HK1078093A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
PCT/JP2003/000017 2001-12-28 2003-01-06 Anticorps diriges contre le facteur de croissance 23 des fibroblastes WO2003057733A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2003202472A AU2003202472B2 (en) 2001-12-28 2003-01-06 Antibodies against fibroblast growth factor 23
US10/500,296 US7923012B2 (en) 2001-12-28 2003-01-06 Antibody against fibroblast growth factor-23
KR1020047010142A KR101016476B1 (ko) 2001-12-28 2003-01-06 섬유아세포 증식 인자-23에 대한 항체
AT03701009T ATE441666T1 (de) 2001-12-28 2003-01-06 Antikírper gegen den fibroblastenwachstumsfaktor 23
DE60329070T DE60329070D1 (de) 2001-12-28 2003-01-06 Antikörper gegen den fibroblastenwachstumsfaktor 23
EP03701009A EP1466925B1 (en) 2001-12-28 2003-01-06 Antibodies against fibroblast growth factor 23
JP2003558047A JP4527982B2 (ja) 2001-12-28 2003-01-06 線維芽細胞増殖因子−２３に対する抗体
CA2471656A CA2471656C (en) 2001-12-28 2003-01-06 Antibody against fibroblast growth factor-23
HK05110064.5A HK1078093A1 (en) 2001-12-28 2005-11-10 Antibodies against fibroblast growth factor 23

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001401689 2001-12-28
JP2001-401689 2001-12-28
JP2002-262020 2002-09-06
JP2002262020 2002-09-06

Publications (1)

Publication Number Publication Date
WO2003057733A1 true WO2003057733A1 (fr) 2003-07-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/000017 WO2003057733A1 (fr) 2001-12-28 2003-01-06 Anticorps diriges contre le facteur de croissance 23 des fibroblastes

Country Status (12)

Country Link
US (1) US7923012B2 (ja)
EP (1) EP1466925B1 (ja)
JP (1) JP4527982B2 (ja)
KR (1) KR101016476B1 (ja)
CN (1) CN100519584C (ja)
AT (1) ATE441666T1 (ja)
AU (1) AU2003202472B2 (ja)
CA (1) CA2471656C (ja)
DE (1) DE60329070D1 (ja)
ES (1) ES2331414T3 (ja)
HK (1) HK1078093A1 (ja)
WO (1) WO2003057733A1 (ja)

Cited By (8)

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Publication number Priority date Publication date Assignee Title
WO2008099969A1 (ja) 2007-02-14 2008-08-21 Kyowa Hakko Kirin Co., Ltd. 抗fgf23抗体及びそれを含む医薬組成物
WO2009133905A1 (ja) * 2008-04-28 2009-11-05 協和発酵キリン株式会社 ヒト線維芽細胞増殖因子23（ヒトfgf23)の作用を抑制するペプチドおよびそれを含む医薬組成物
US7981419B2 (en) 2000-08-11 2011-07-19 Kyowa Hakko Kirin Co., Ltd. Method for treating hypophosphatemic bone diseases using FGF-23 antibody
WO2012029837A1 (ja) * 2010-08-31 2012-03-08 協和メデックス株式会社 線維芽細胞増殖因子－２３の測定方法及び測定試薬
WO2012147670A1 (ja) 2011-04-25 2012-11-01 協和メデックス株式会社 腎不全の予後判定方法
WO2017159473A1 (ja) * 2016-03-14 2017-09-21 協和メデックス株式会社 慢性腎臓病患者における高リン血症の発症のしやすさを試験する方法
WO2018221544A1 (ja) 2017-05-31 2018-12-06 協和メデックス株式会社 線維芽細胞増殖因子－２３の測定方法、測定試薬及び測定キット
WO2019026918A1 (ja) * 2017-08-01 2019-02-07 株式会社国際電気通信基礎技術研究所 皮膚のバイオマーカー

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ES2331414T3 (es) 2001-12-28 2010-01-04 Kyowa Hakko Kirin Co Ltd Anticuerpos contra el factor 23 de crecimiento de fibroblastos.
CA2636367A1 (en) * 2005-07-18 2007-01-25 Trustees Of Boston University Method to inhibit proliferation and growth of metastases
US20090247647A1 (en) * 2006-03-28 2009-10-01 Brian Genge Method of Stimulating Proteoglycan Synthesis in Cells
WO2008092019A1 (en) * 2007-01-25 2008-07-31 Mayo Foundation For Medical Education And Research Fgf-23 polypeptides
BR112012025047A2 (pt) 2010-03-31 2016-06-21 Stabilitech Ltd formulações líquidas estabilizadas
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WO2012055096A1 (zh) * 2010-10-27 2012-05-03 温州医学院生物与天然药物开发中心有限公司 抗fgf-23抗体的制备方法及用途
GB201117233D0 (en) * 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
US20140273031A1 (en) * 2013-03-15 2014-09-18 The Cleveland Clinic Foundation In-vitro method for monoclonal antibody production
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
ES2851674T3 (es) 2014-06-09 2021-09-08 Ultragenyx Pharmaceutical Inc Control efectivo y eficaz de fosfato sérico para una formación ósea óptima
CN104502596A (zh) * 2014-12-23 2015-04-08 温州医科大学 一种慢性肾病诊断试剂盒
CN105699664A (zh) * 2015-04-13 2016-06-22 陈柏龄 Fgf23检测试剂盒及其制备方法
WO2016208776A1 (ja) 2015-06-25 2016-12-29 株式会社国際電気通信基礎技術研究所 多器官連関システムを基盤とした予測装置、及び予測プログラム
CL2015003047A1 (es) * 2015-10-15 2016-06-17 Univ Chile Método ex vivo para detectar precozmente injuria renal aguda en pacientes críticos, que comprende la mediciom en una muestra de tres proteinas como biomarcadores, factor de crecimiento fibroblástico 23, klotho y eritropoyetina
CN114778845A (zh) * 2016-03-29 2022-07-22 无限生物制药公司 药物组合物或食品组合物及评价活性成分体内效果的方法
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions
WO2021128065A1 (zh) * 2019-12-25 2021-07-01 广州菲康生物技术有限公司 人fgf-23的荧光免疫层析试纸和人fgf-23的荧光免疫层析检测试剂盒

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Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7981419B2 (en) 2000-08-11 2011-07-19 Kyowa Hakko Kirin Co., Ltd. Method for treating hypophosphatemic bone diseases using FGF-23 antibody
JP4800396B2 (ja) * 2007-02-14 2011-10-26 協和発酵キリン株式会社 抗ｆｇｆ２３抗体及びそれを含む医薬組成物
EP2502996A3 (en) * 2007-02-14 2013-04-10 Kyowa Hakko Kirin Co., Ltd. Anti-FGF23 antibody and pharmaceutical composition comprising the same
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AU2003202472B2 (en) 2009-11-26
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US7923012B2 (en) 2011-04-12
CA2471656C (en) 2012-07-31
EP1466925A4 (en) 2006-01-04
CN100519584C (zh) 2009-07-29
US20050048058A1 (en) 2005-03-03
CN1639193A (zh) 2005-07-13
EP1466925B1 (en) 2009-09-02
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CA2471656A1 (en) 2003-07-17
JP4527982B2 (ja) 2010-08-18
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