WO2003042185A1 - Inhibiteurs de la xanthine oxydase - Google Patents

Inhibiteurs de la xanthine oxydase Download PDF

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Publication number
WO2003042185A1
WO2003042185A1 PCT/JP2002/011893 JP0211893W WO03042185A1 WO 2003042185 A1 WO2003042185 A1 WO 2003042185A1 JP 0211893 W JP0211893 W JP 0211893W WO 03042185 A1 WO03042185 A1 WO 03042185A1
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WO
WIPO (PCT)
Prior art keywords
xanthine oxidase
oxidase inhibitors
halogeno
carboxyl
alkyl
Prior art date
Application number
PCT/JP2002/011893
Other languages
English (en)
French (fr)
Inventor
Shinichi Yoshida
Atsushi Tendo
Kunio Kobayashi
Nobutaka Mochiduki
Tomio Yamakawa
Yoriko Shinohara
Original Assignee
Nippon Chemiphar Co.,Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co.,Ltd. filed Critical Nippon Chemiphar Co.,Ltd.
Priority to DK02780099T priority Critical patent/DK1452528T3/da
Priority to KR1020047007333A priority patent/KR100919147B1/ko
Priority to JP2003544021A priority patent/JP4634037B2/ja
Priority to US10/495,844 priority patent/US7253154B2/en
Priority to DE60228316T priority patent/DE60228316D1/de
Priority to EP02780099A priority patent/EP1452528B1/en
Publication of WO2003042185A1 publication Critical patent/WO2003042185A1/ja
Priority to US11/829,286 priority patent/US20070265283A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PCT/JP2002/011893 2001-11-16 2002-11-14 Inhibiteurs de la xanthine oxydase WO2003042185A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DK02780099T DK1452528T3 (da) 2001-11-16 2002-11-14 Xanthinoxidaserinhibitorer
KR1020047007333A KR100919147B1 (ko) 2001-11-16 2002-11-14 크산틴 옥시다제 저해제
JP2003544021A JP4634037B2 (ja) 2001-11-16 2002-11-14 キサンチンオキシダーゼ阻害剤
US10/495,844 US7253154B2 (en) 2001-11-16 2002-11-14 Substituted thiazolopyrimidines as xanthine oxidase inhibitors
DE60228316T DE60228316D1 (en) 2001-11-16 2002-11-14 Xanthinoxidaseinhibitoren
EP02780099A EP1452528B1 (en) 2001-11-16 2002-11-14 Xanthine oxidase inhibitors
US11/829,286 US20070265283A1 (en) 2001-11-16 2007-07-27 Xanthine Oxidase Inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001352340 2001-11-16
JP2001-352340 2001-11-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/829,286 Division US20070265283A1 (en) 2001-11-16 2007-07-27 Xanthine Oxidase Inhibitor

Publications (1)

Publication Number Publication Date
WO2003042185A1 true WO2003042185A1 (fr) 2003-05-22

Family

ID=19164532

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/011893 WO2003042185A1 (fr) 2001-11-16 2002-11-14 Inhibiteurs de la xanthine oxydase

Country Status (11)

Country Link
US (2) US7253154B2 (ja)
EP (1) EP1452528B1 (ja)
JP (2) JP4634037B2 (ja)
KR (1) KR100919147B1 (ja)
CN (2) CN101092400A (ja)
AT (1) ATE404541T1 (ja)
DE (1) DE60228316D1 (ja)
DK (1) DK1452528T3 (ja)
ES (1) ES2309213T3 (ja)
PT (1) PT1452528E (ja)
WO (1) WO2003042185A1 (ja)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105803A2 (en) * 2004-04-28 2005-11-10 Cv Therapeutics, Inc. Purine derivatives as a1 adenosine receptor antagonists
WO2005121153A1 (ja) 2004-06-14 2005-12-22 Nippon Chemiphar Co., Ltd. 縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤
WO2007004688A1 (ja) * 2005-07-01 2007-01-11 Nippon Chemiphar Co., Ltd. キサンチンオキシダーゼ阻害剤
WO2007148835A1 (ja) 2006-06-22 2007-12-27 Nippon Chemiphar Co., Ltd. 抗ガン剤耐性克服剤
US20080096904A1 (en) * 2004-07-21 2008-04-24 Johnson Richard J Compositions and methods for treatment and prevention of insulin resistance
KR101191071B1 (ko) 2004-06-14 2012-10-15 닛뽕 케미파 가부시키가이샤 축합 피리미딘 유도체 및 크산틴 옥시다제 저해제
WO2015105195A1 (ja) * 2014-01-10 2015-07-16 日本ケミファ株式会社 肺高血圧症治療薬
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9233961B2 (en) 2013-03-15 2016-01-12 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9303034B2 (en) 2013-12-19 2016-04-05 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US10413546B2 (en) 2015-02-24 2019-09-17 National University Corporation Tottori University Drug for preventing and/or treating dementia
CN110283137A (zh) * 2019-06-13 2019-09-27 爱斯特（成都）生物制药股份有限公司 一种2-(4-溴苯基)-1,3-苯并恶唑的制备方法

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ES2524803T3 (es) 2002-12-19 2014-12-12 The Scripps Research Institute Composiciones y métodos para estabilizar la transtiretina e inhibir el plegamiento anómalo de la transtiretina
EP2074223A4 (en) * 2006-09-15 2010-03-10 Foldrx Pharmaceuticals Inc TEST PROCEDURE FOR THE DETECTION OF PROTEINS IN THE NATIVE CONDITION AND FOR THE IDENTIFICATION OF THE STABILITY OF PROTEINS IN THE NATIVE CONDITION MODULATING COMPOUNDS
MX2009010491A (es) * 2007-04-11 2009-11-09 Kissei Pharmaceutical Derivado heterociclico de 5 miembros y su uso para propositos medicos.
EP2165705A1 (en) 2008-09-18 2010-03-24 Centre National de la Recherche Scientifique (CNRS) Use of a compound capable of reducing the uric acid level for the prevention and/or the treatment of lung inflammation and fibrosis
JP5673008B2 (ja) 2010-08-11 2015-02-18 ソニー株式会社 画像処理装置、立体画像表示装置および立体画像表示システム、ならびに立体画像表示装置の視差ずれ検出方法および立体画像表示装置の製造方法
CN102095825B (zh) * 2010-12-08 2014-07-23 中国科学院长春应用化学研究所 超高效液相色谱和质谱联用筛选黄嘌呤氧化酶抑制剂的方法
SG2014013270A (en) 2011-09-16 2014-05-29 Pfizer Solid forms of a transthyretin dissociation inhibitor
CN106146533B (zh) * 2016-07-14 2018-04-03 华润赛科药业有限责任公司 含硫杂环羧酸类衍生物、其制备方法和应用
WO2020009374A1 (ko) * 2018-07-04 2020-01-09 고려대학교 세종산학협력단 4-치환 옥사졸로퀴놀리논 유도체, 약학적으로 허용되는 이의 염인 화합물 및 이를 유효성분으로 포함하는 천식 또는 아토피 등의 알러지성 질환의 예방 또는 치료용 약학 조성물
CN111620833A (zh) * 2020-06-05 2020-09-04 青岛伯川特聚科技有限公司 一种2-苯基苯并噁唑类化合物的制备方法
CN113004188B (zh) * 2021-03-16 2022-09-20 沈阳药科大学 一种吲哚衍生物及制备方法和应用

Citations (6)

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US4038396A (en) * 1975-02-24 1977-07-26 Merck & Co., Inc. Anti-inflammatory oxazole[4,5-b]pyridines
EP0024290A1 (de) * 1979-07-11 1981-03-04 Dr. Karl Thomae GmbH 8-Phenyl-purine, ihre Herstellung sowie sie enthaltende Arzneimittel
GB2119377A (en) * 1982-05-03 1983-11-16 Lilly Co Eli Imidazo pyridines
JPS62246581A (ja) * 1986-04-17 1987-10-27 Chugai Pharmaceut Co Ltd フロベンゾオキサゾ−ル誘導体
EP0260744A2 (en) * 1986-09-15 1988-03-23 Janssen Pharmaceutica N.V. (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives
JPH03258770A (ja) * 1990-03-08 1991-11-19 Tanabe Seiyaku Co Ltd ベンズアゾール誘導体、その製法及びその合成中間体

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JP2004503553A (ja) * 2000-06-14 2004-02-05 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ６，５−縮合二環式複素環
GB0205256D0 (en) 2002-03-06 2002-04-17 Oxford Glycosciences Uk Ltd Novel compounds

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EP0024290A1 (de) * 1979-07-11 1981-03-04 Dr. Karl Thomae GmbH 8-Phenyl-purine, ihre Herstellung sowie sie enthaltende Arzneimittel
GB2119377A (en) * 1982-05-03 1983-11-16 Lilly Co Eli Imidazo pyridines
JPS62246581A (ja) * 1986-04-17 1987-10-27 Chugai Pharmaceut Co Ltd フロベンゾオキサゾ−ル誘導体
EP0260744A2 (en) * 1986-09-15 1988-03-23 Janssen Pharmaceutica N.V. (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives
JPH03258770A (ja) * 1990-03-08 1991-11-19 Tanabe Seiyaku Co Ltd ベンズアゾール誘導体、その製法及びその合成中間体

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Title
BAKER B.R. ET AL.: "Irreversible enzyme inhibitors XCIII. Hydrophobic bonding to xanthine oxidase by some phenylpurines", J. PHARM. SCI., vol. 56, no. 8, 1967, pages 959 - 962, XP002963449 *
BAKER B.R. ET AL.: "Irreversible enzyme inhibitors. CXXV. Active-site-directed irreversible inhibitors of xanthine oxidase derived from arylpurines and pyrazolo(3,4-d)pyrimidines bearing a terminal sulfonyl fluoride", J. MED. CHEM., vol. 11, 1968, pages 656 - 661, XP002963445 *
BAKER B.R. ET AL.: "Irreversible enzyme inhibitors. CXXVI. Hydrocarbon interaction with xanthine oxidase by phenyl substituents on purines and pyrazolo(3,4-d)pyrimidines", J. MED. CHEM., vol. 11, 1968, pages 661 - 666, XP002963444 *
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BERGMANN F. ET AL.: "Influence of 8-substituents on the oxidation of hypoxanthine and 6-thioxopurine by bovine milk xanthine oxidase", BIOCHIM. BIOPHYS. ACTA, vol. 480, no. 1, 1977, pages 39 - 46, XP001096247 *
BERGMANN F. ET AL.: "Oxidation of hypoxanthines, bearing 8-aryl or 8-pyridyl substituents, by bovine milk xanthine oxidase", BIOCHIM. BIOPHYS. ACTA, vol. 484, no. 2, 1977, pages 275 - 289, XP002963446 *
BIAGI G. ET AL.: "Synthesis and biological evaluation of new imidazole. Pyrimidine and purine derivatives and analogs as inhibitors of xanthine oxidase", J. MED. CHEM., vol. 39, 1996, pages 2529 - 2535, XP002963447 *
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BRONS H.J. ET AL.: "Inhibition of bacterial xanthine oxidase from arthrobacter M4 by 5,6-diaminouracil", BIOTECHNOLOGY AND APPLIED BIOTECHNOLOGY, vol. 9, no. 1, 1987, pages 66 - 73, XP002963448 *
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CHEMICAL ABSTRACTS, vol. 103, 1985, Columbus, Ohio, US; abstract no. 189365, REG. NO. 51234-28-7, OSMAN F. ET AL.: "Possible effects of some non-steroidal anti-inflammatory drugs on superoxide formation in inflammation" XP002963453 *
CHEMICAL ABSTRACTS, vol. 60, no. 1, 6 January 1964, Columbus, Ohio, US; abstract no. 884G, REG.NO.93648-62-5,92965-63-4,92965-64-5, MNDZHOYAN A.L. ET AL.: "Antibacterial and antiprotozoal activity of some benzimidazole derivatives" page 1963/64; XP002963454 *
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RAINSFORD K.D. ET AL.: "Preliminary investigations on the pharmacological control of catabolin-induced cartilage destruction in vitro", AGENTS AND ACTIONS, vol. 16, no. 1-2, 1985, pages 55 - 57, XP002963452 *

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007535560A (ja) * 2004-04-28 2007-12-06 シーブイ・セラピューティクス・インコーポレイテッド Ａ１アデノシンレセプターアンタゴニスト
WO2005105803A2 (en) * 2004-04-28 2005-11-10 Cv Therapeutics, Inc. Purine derivatives as a1 adenosine receptor antagonists
WO2005105803A3 (en) * 2004-04-28 2006-02-09 Cv Therapeutics Inc Purine derivatives as a1 adenosine receptor antagonists
JP2013189460A (ja) * 2004-06-14 2013-09-26 Nippon Chemiphar Co Ltd キサンチンオキシダーゼ阻害剤
JPWO2005121153A1 (ja) * 2004-06-14 2008-04-10 日本ケミファ株式会社 縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤
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JP5297414B2 (ja) 2013-09-25
JP4634037B2 (ja) 2011-02-16
KR100919147B1 (ko) 2009-09-25
US20070265283A1 (en) 2007-11-15
ATE404541T1 (de) 2008-08-15
JP2010180232A (ja) 2010-08-19
DK1452528T3 (da) 2008-11-10
EP1452528A1 (en) 2004-09-01
EP1452528A4 (en) 2005-11-16
US7253154B2 (en) 2007-08-07
CN101092400A (zh) 2007-12-26
US20050090472A1 (en) 2005-04-28
JPWO2003042185A1 (ja) 2005-03-10
EP1452528B1 (en) 2008-08-13
ES2309213T3 (es) 2008-12-16
DE60228316D1 (en) 2008-09-25
PT1452528E (pt) 2008-10-14

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