WO2003040096A3 - Derives 1,3-diamino-2-hydroxypropane n-n'-substitues - Google Patents

Derives 1,3-diamino-2-hydroxypropane n-n'-substitues Download PDF

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Publication number
WO2003040096A3
WO2003040096A3 PCT/US2002/036072 US0236072W WO03040096A3 WO 2003040096 A3 WO2003040096 A3 WO 2003040096A3 US 0236072 W US0236072 W US 0236072W WO 03040096 A3 WO03040096 A3 WO 03040096A3
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WO
WIPO (PCT)
Prior art keywords
diamino
substituted
hydroxypropane derivatives
hydroxypropane
derivatives
Prior art date
Application number
PCT/US2002/036072
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English (en)
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WO2003040096A2 (fr
Inventor
Varghese John
Michel Maillard
Barbara Jagodzinska
James P Beck
Andrea Gailunas
Larry Fang
Jennifer Sealy
Ruth Tenbrink
John Freskos
John Mickelson
Lakshman Samala
Roy Hom
Original Assignee
Elan Pharm Inc
Upjohn Co
Varghese John
Michel Maillard
Barbara Jagodzinska
James P Beck
Andrea Gailunas
Larry Fang
Jennifer Sealy
Ruth Tenbrink
John Freskos
John Mickelson
Lakshman Samala
Roy Hom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0214035-7A priority Critical patent/BR0214035A/pt
Application filed by Elan Pharm Inc, Upjohn Co, Varghese John, Michel Maillard, Barbara Jagodzinska, James P Beck, Andrea Gailunas, Larry Fang, Jennifer Sealy, Ruth Tenbrink, John Freskos, John Mickelson, Lakshman Samala, Roy Hom filed Critical Elan Pharm Inc
Priority to IL16188102A priority patent/IL161881A0/xx
Priority to EA200400648A priority patent/EA200400648A1/ru
Priority to MXPA04004428A priority patent/MXPA04004428A/es
Priority to JP2003542142A priority patent/JP2005520791A/ja
Priority to CA002466284A priority patent/CA2466284A1/fr
Priority to NZ533107A priority patent/NZ533107A/en
Priority to EP02793909A priority patent/EP1453789A2/fr
Priority to AU2002359376A priority patent/AU2002359376B2/en
Priority to APAP/P/2004/003049A priority patent/AP2004003049A0/en
Priority to YUP-505/04A priority patent/RS50504A/sr
Priority to ARP020104299A priority patent/AR039555A1/es
Publication of WO2003040096A2 publication Critical patent/WO2003040096A2/fr
Publication of WO2003040096A3 publication Critical patent/WO2003040096A3/fr
Priority to IS7255A priority patent/IS7255A/is
Priority to IL161881A priority patent/IL161881A/en
Priority to TNP2004000082A priority patent/TNSN04082A1/en
Priority to HR20040518A priority patent/HRP20040518A2/xx
Priority to NO20042359A priority patent/NO20042359L/no

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    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
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    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

L'invention concerne des composés de formule (I) dans laquelle les variables RN, RC, R1, R25, R2 et R3 ont la signification mentionnée dans la description. Ces composés ont une activité d'inhibiteurs de bétasecrétase et s'utilisent de ce fait dans le traitement d'une variété de troubles tels que la maladie d'Alzheimer.
PCT/US2002/036072 2001-11-08 2002-11-08 Derives 1,3-diamino-2-hydroxypropane n-n'-substitues WO2003040096A2 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
EP02793909A EP1453789A2 (fr) 2001-11-08 2002-11-08 Derives 1,3-diamino-2-hydroxypropane n-n'-substitues
IL16188102A IL161881A0 (en) 2001-11-08 2002-11-08 N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
EA200400648A EA200400648A1 (ru) 2001-11-08 2002-11-08 N, n'-замещенные производные 1,3-диамино-2-гидроксипропана
MXPA04004428A MXPA04004428A (es) 2001-11-08 2002-11-08 Derivados de 2,3-diamino-2-hidroxipropano n,n`-sustituidos.
JP2003542142A JP2005520791A (ja) 2001-11-08 2002-11-08 Ｎ，ｎ’−置換−１，３−ジアミノ−２−ヒドロキシプロパン誘導体
CA002466284A CA2466284A1 (fr) 2001-11-08 2002-11-08 Derives 1,3-diamino-2-hydroxypropane n-n'-substitues
APAP/P/2004/003049A AP2004003049A0 (en) 2001-11-08 2002-11-08 N,N' -substituted-1,3-diamino -2-hydroxypropane derivatives.
AU2002359376A AU2002359376B2 (en) 2001-11-08 2002-11-08 N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives
NZ533107A NZ533107A (en) 2001-11-08 2002-11-08 N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives
BR0214035-7A BR0214035A (pt) 2001-11-08 2002-11-08 Composto
YUP-505/04A RS50504A (en) 2001-11-08 2002-11-08 N,n'-substituted-1,3-diamino-2- hydroxypropane derivatives
ARP020104299A AR039555A1 (es) 2001-11-08 2002-11-08 Derivados n,n'-sustituidos de 1,3-diamino-2-hidroxipropano
IS7255A IS7255A (is) 2001-11-08 2004-05-07 Propan afleiður með mismunandi sethópa
IL161881A IL161881A (en) 2001-11-08 2004-05-09 N,n'-substituted-1,3-diamino-2- hydroxypropane derivatives
TNP2004000082A TNSN04082A1 (en) 2001-11-08 2004-05-10 N,n'-substituted-1,3-diamino-2-hydroxypropane derivatives
HR20040518A HRP20040518A2 (en) 2001-11-08 2004-06-07 N,n'-substituted-1,3-diamino-2-hydroxypropane derivatives
NO20042359A NO20042359L (no) 2001-12-28 2004-06-07 N,N, substituerte-1,3-diamino-2-hydroksypropanderivater

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US33712201P 2001-11-08 2001-11-08
US60/337,122 2001-11-08
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