WO2000043395A1 - Substituted porphyrins - Google Patents

Substituted porphyrins Download PDF

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Publication number
WO2000043395A1
WO2000043395A1 PCT/US2000/002062 US0002062W WO0043395A1 WO 2000043395 A1 WO2000043395 A1 WO 2000043395A1 US 0002062 W US0002062 W US 0002062W WO 0043395 A1 WO0043395 A1 WO 0043395A1
Authority
WO
WIPO (PCT)
Prior art keywords
same
compound
manganese
mmol
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/002062
Other languages
English (en)
French (fr)
Other versions
WO2000043395A8 (en
Inventor
James D. Crapo
Brian J. Day
Michael P. Trova
Polivini Jolicia F. Gauuan
Douglas B. Kitchen
Irwin Fridovich
Ines Batinic-Haberle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Jewish Health
Aeolus Pharmaceuticals Inc
Duke University
Original Assignee
Aeolus Pharmaceuticals Inc
National Jewish Medical and Research Center
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL14450300A priority Critical patent/IL144503A0/xx
Priority to AT00905776T priority patent/ATE312103T1/de
Priority to NZ513164A priority patent/NZ513164A/xx
Priority to JP2000594811A priority patent/JP4501128B2/ja
Priority to MXPA01007451A priority patent/MXPA01007451A/es
Priority to EP00905776A priority patent/EP1155019B1/en
Priority to BRPI0007720-8B1A priority patent/BR0007720B1/pt
Priority to HK02109292.4A priority patent/HK1047744B/xx
Priority to AU27407/00A priority patent/AU779283B2/en
Application filed by Aeolus Pharmaceuticals Inc, National Jewish Medical and Research Center, Duke University filed Critical Aeolus Pharmaceuticals Inc
Priority to CA002359116A priority patent/CA2359116C/en
Priority to DE60024588T priority patent/DE60024588T2/de
Publication of WO2000043395A1 publication Critical patent/WO2000043395A1/en
Publication of WO2000043395A8 publication Critical patent/WO2000043395A8/en
Priority to IL144503A priority patent/IL144503A/en
Anticipated expiration legal-status Critical
Priority to IL183953A priority patent/IL183953A/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines

Definitions

  • the compounds of the invention can also be used in methods designed to regulate NO- levels by targeting the above-described porphines to strategic locations.
  • NO- is an intercellular signal and, as such, NO- must traverse the extracellular matrix to exert its effects.
  • NO- is highly sensitive to inactivation mediated by O : " present in the extracellular spaces.
  • the methine (meso) substituted porphyrins of the invention can increase bioavalability of NO' by preventing its degradation by O- ' .
  • the invention further relates to methods of treating memory disorders. It is believed that nitric oxide is a neurotransmitter involved in long-term memory potentiation. Using an EC-SOD knocked-out mouse model (Carlsson et al. Proc. Natl. Acad. Sci. USA 92:6264 (1995)), it can be shown that learning impairment correlates with reduced superoxide scavenging in extracellular spaces of the brain. Reduced scavenging results in higher extracellular O 2 ' levels. O : ' is believed to react with nitric oxide thereby preventing or inhibiting nitric oxide-mediated neurotransmission and thus long-term memory potentiation.
  • the mimetics of the invention particularly, metal bound forms, can be used to treat dementias and memory/learning disorders. 00/43395
  • the animal received 0.25 mg/kg/24 hr given i.v. in a continuous infusion over the entire 10 day study period (see Fig. 2). This animal showed marked improvement of the oxygenation index. There was no evidence of clinical decompensation of the lungs at days 9 and 10. This suggests that Aeol-V can be used to treat oxidant stress in the premature newborn.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/US2000/002062 1999-01-25 2000-01-25 Substituted porphyrins Ceased WO2000043395A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
AU27407/00A AU779283B2 (en) 1999-01-25 2000-01-25 Substituted porphyrins
NZ513164A NZ513164A (en) 1999-01-25 2000-01-25 Substituted porphyrins
JP2000594811A JP4501128B2 (ja) 1999-01-25 2000-01-25 置換ポルフィリン
MXPA01007451A MXPA01007451A (es) 1999-01-25 2000-01-25 Porfirinas sustituidas.
EP00905776A EP1155019B1 (en) 1999-01-25 2000-01-25 Substituted porphyrins and their therapeutic use
BRPI0007720-8B1A BR0007720B1 (pt) 1999-01-25 2000-01-25 Porfirinas substituídas e método de proteção de células contra toxicidade induzida por oxidante
HK02109292.4A HK1047744B (en) 1999-01-25 2000-01-25 Substituted porphyrins
IL14450300A IL144503A0 (en) 1999-01-25 2000-01-25 Substituted porphyrins
CA002359116A CA2359116C (en) 1999-01-25 2000-01-25 Substituted porphyrins
AT00905776T ATE312103T1 (de) 1999-01-25 2000-01-25 Substituierte porphyrine und deren therapeutische verwendungen
DE60024588T DE60024588T2 (de) 1999-01-25 2000-01-25 Substituierte porphyrine und deren therapeutische verwendungen
IL144503A IL144503A (en) 1999-01-25 2001-07-23 Dual-tetra-porphyrins - metabolized, to treat and prevent oxidation-induced toxicity, and some such new porphyrins
IL183953A IL183953A (en) 1999-01-25 2007-06-14 Method of reducing oxidant induced damage of a food product, a pharmaceutical or stored blood and novel compounds therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11701099P 1999-01-25 1999-01-25
US60/117,010 1999-01-25

Publications (2)

Publication Number Publication Date
WO2000043395A1 true WO2000043395A1 (en) 2000-07-27
WO2000043395A8 WO2000043395A8 (en) 2000-08-31

Family

ID=22370524

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/002062 Ceased WO2000043395A1 (en) 1999-01-25 2000-01-25 Substituted porphyrins

Country Status (17)

Country Link
US (7) US6544975B1 (https=)
EP (3) EP2295435A1 (https=)
JP (1) JP4501128B2 (https=)
KR (1) KR100753184B1 (https=)
CN (1) CN1156478C (https=)
AT (2) ATE312103T1 (https=)
AU (1) AU779283B2 (https=)
BR (1) BR0007720B1 (https=)
CA (1) CA2359116C (https=)
DE (1) DE60024588T2 (https=)
DK (2) DK1616869T3 (https=)
ES (2) ES2385486T3 (https=)
IL (3) IL144503A0 (https=)
MX (1) MXPA01007451A (https=)
NZ (1) NZ513164A (https=)
WO (1) WO2000043395A1 (https=)
ZA (1) ZA200106107B (https=)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2806911A1 (fr) * 2000-03-28 2001-10-05 Univ Rene Descartes Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires
US6479477B1 (en) 1998-04-24 2002-11-12 Duke University Substituted porphyrins
US6544975B1 (en) 1999-01-25 2003-04-08 National Jewish Medical And Research Center Substituted porphyrins
US6583132B1 (en) 1993-10-15 2003-06-24 Duke University Oxidant scavengers
WO2002060383A3 (en) * 2001-01-19 2003-12-11 Nat Jewish Med & Res Center Cancer therapy
EP1442747A1 (en) * 1993-10-15 2004-08-04 Duke University Superoxide dismutase and mimetics thereof
AU2002253619B2 (en) * 2001-04-27 2007-05-17 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and antitumor agent containing the same active ingredients
US7432369B2 (en) 2004-03-29 2008-10-07 Inotek Pharmaceuticals Corporation Pyridyl-substituted porphyrin compounds and methods of use thereof
WO2008070579A3 (en) * 2006-12-01 2009-03-19 Univ Loma Linda Med Inhibition of brain enzymes involved in cerebral amyloid angiopathy and macular degeneration
EP1439842A4 (en) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE
KR20110017398A (ko) * 2008-05-23 2011-02-21 내셔날 쥬이쉬 헬스 알킬화 종으로의 노출과 관련된 상해를 치료하는 방법
EP2435387A4 (en) * 2009-05-26 2013-03-20 Univ Duke PROCESS FOR PROVIDING NERVE PROTECTION THROUGH THE USE OF PORPHYRINES
US20130225545A1 (en) * 2010-10-06 2013-08-29 Aeolus Sciences, Inc. Porphyrin treatment of neurodegenerative diseases
WO2015034778A1 (en) * 2013-09-03 2015-03-12 Biomimetix J.V., Llc Methods of treating erectile dysfunction
WO2016077857A1 (de) * 2014-11-20 2016-05-26 Wenatex Forschung - Entwicklung - Produktion Gmbh Antimikrobielles mittel zum biociden ausrüsten von polymeren
US10064871B2 (en) 2014-01-22 2018-09-04 Biomimetix Jv, Llc Methods of treating skin disorders
US10080759B2 (en) 2014-01-22 2018-09-25 Duke University Methods of treating pruritus
WO2020250207A1 (en) * 2019-06-14 2020-12-17 Universidade De Coimbra Small cationic ortho-5,15-di-heteroaryl-porphyrins derivatives and their applications in photoinactivation of microorganisms

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US7485721B2 (en) * 2002-06-07 2009-02-03 Duke University Substituted porphyrins
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US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
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GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
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US7885698B2 (en) * 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US20080289053A1 (en) * 2007-05-15 2008-11-20 The Regents Of The University Of California Methods and systems for identifying modulators of longevity
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US8791099B2 (en) * 2007-08-28 2014-07-29 Technion Research And Development Foundation Ltd. Transition metal complexes of corroles for preventing cardiovascular diseases or disorders
US8987245B2 (en) 2008-04-02 2015-03-24 Jonathan R. Brestoff Parker Composition and method for affecting obesity and related conditions
US8598150B1 (en) 2008-04-02 2013-12-03 Jonathan R. Brestoff Composition and method for affecting obesity and related conditions
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JP5823988B2 (ja) * 2011-01-31 2015-11-25 国立大学法人宇都宮大学 ポルフィリン型骨格を有する化合物の金属錯体の製造方法
EP2785339A4 (en) 2011-12-02 2015-11-25 Univ Colorado Regents NEUROLOGICAL TREATMENTS WITH METALOPORPHYRINE
CN102775415B (zh) * 2012-07-10 2014-10-22 西北大学 一种卟啉的合成方法
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MX2016006644A (es) * 2013-11-22 2016-12-02 Aeolus Sciences Inc Síntesis y formulaciones de compuestos de porfirina.
AU2014374361B9 (en) 2013-12-31 2019-07-04 Abbott Diabetes Care Inc. Self-powered analyte sensor and devices using the same
US10385082B2 (en) 2015-08-18 2019-08-20 University of Pittsburgh—of the Commonwealth System of Higher Education Antioxidant compounds and their use
EP3558902A4 (en) * 2016-12-20 2020-06-24 Duke University METHOD FOR PRODUCING PHARMACEUTICAL COMPOUNDS WITH SUBSTITUTED PORPHYRINE AND COMPOSITIONS
CN110352036B (zh) * 2016-12-21 2022-11-15 普罗菲尤萨股份有限公司 可聚合的近红外染料
KR20210040953A (ko) 2018-06-27 2021-04-14 프로퓨사 인코퍼레이티드 근적외선 글루코스 센서
CN110028514B (zh) * 2019-05-30 2021-07-02 湖南科技大学 5,10,15,20-四芳基-2,3-咪唑稠合-21-碳叶绿素化合物及制备方法
US12201649B2 (en) 2021-11-12 2025-01-21 Villanova University Pharmaceutical composition comprising oxidizable biphenol and manganese porphyrin, and method of using the same
CN116284017B (zh) * 2023-03-27 2024-03-22 中国科学院青岛生物能源与过程研究所 一种利用仿酶高效催化氧化制备酰胺化合物的方法

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