WO1997044671A1 - Procede et appareil pour commander des particules magnetiques a l'aide d'une machine de pipettage - Google Patents

Procede et appareil pour commander des particules magnetiques a l'aide d'une machine de pipettage Download PDF

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Publication number
WO1997044671A1
WO1997044671A1 PCT/JP1996/001333 JP9601333W WO9744671A1 WO 1997044671 A1 WO1997044671 A1 WO 1997044671A1 JP 9601333 W JP9601333 W JP 9601333W WO 9744671 A1 WO9744671 A1 WO 9744671A1
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic particles
liquid
tip
processing
magnetic field
Prior art date
Application number
PCT/JP1996/001333
Other languages
English (en)
Japanese (ja)
Inventor
Hideji Tajima
Original Assignee
Precision System Science Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Precision System Science Co., Ltd. filed Critical Precision System Science Co., Ltd.
Priority to CA002255658A priority Critical patent/CA2255658C/fr
Priority to AU57030/96A priority patent/AU738336B2/en
Priority to JP54197597A priority patent/JP3682302B2/ja
Priority to EP96915198A priority patent/EP0965842B1/fr
Priority to US09/197,408 priority patent/US6509193B1/en
Priority to DE69638151T priority patent/DE69638151D1/de
Priority to PCT/JP1996/001333 priority patent/WO1997044671A1/fr
Publication of WO1997044671A1 publication Critical patent/WO1997044671A1/fr
Priority to NO19990558A priority patent/NO330495B1/no

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25625—Dilution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un procédé et un appareil pour commander des particules magnétiques à l'aide d'une machine de pipettage pour effectuer un processus de pipettage en vue de la collecte de particules magnétiques, de leur séparation d'un liquide, de leur remise en suspension avec une précision, une sensibilité et une fiabilité élevées. Une région de séparation, où agit un champ magnétique, est disposée à l'intérieur d'un passage de liquide reliant une partie terminale distale à une partie réservoir. Lorsqu'un liquide tenant en suspension les particules magnétiques passe par cette région de séparation d'une partie pipette pour aspirer ou refouler le liquide, le champ magnétique est appliqué à la région de séparation à travers la surface latérale du passage de liquide, de sorte que les particules magnétiques sont attirées vers la surface latérale intérieure du passage de liquide et peuvent être séparées de ce dernier.
PCT/JP1996/001333 1996-05-20 1996-05-20 Procede et appareil pour commander des particules magnetiques a l'aide d'une machine de pipettage WO1997044671A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002255658A CA2255658C (fr) 1996-05-20 1996-05-20 Procede et appareil pour commander des particules magnetiques a l'aide d'une machine de pipettage
AU57030/96A AU738336B2 (en) 1996-05-20 1996-05-20 Control method and apparatus for controlling magnetic particles by a sample distributor
JP54197597A JP3682302B2 (ja) 1996-05-20 1996-05-20 分注機による磁性体粒子の制御方法およびその装置
EP96915198A EP0965842B1 (fr) 1996-05-20 1996-05-20 Procede et appareil pour commander des particules magnetiques a l'aide d'une machine de pipettage
US09/197,408 US6509193B1 (en) 1996-05-20 1996-05-20 Method and apparatus for controlling magnetic particles by pipetting machine
DE69638151T DE69638151D1 (de) 1996-05-20 1996-05-20 Prozess und apparat zur kontrolle magnetischer teilchen mit hilfe einer pipettier-maschine
PCT/JP1996/001333 WO1997044671A1 (fr) 1996-05-20 1996-05-20 Procede et appareil pour commander des particules magnetiques a l'aide d'une machine de pipettage
NO19990558A NO330495B1 (no) 1996-05-20 1999-02-05 Kontrollmetode og apparat for kontroll av magnetiske partikler ved hjelp av en provefordeler

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1996/001333 WO1997044671A1 (fr) 1996-05-20 1996-05-20 Procede et appareil pour commander des particules magnetiques a l'aide d'une machine de pipettage

Publications (1)

Publication Number Publication Date
WO1997044671A1 true WO1997044671A1 (fr) 1997-11-27

Family

ID=14153304

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1996/001333 WO1997044671A1 (fr) 1996-05-20 1996-05-20 Procede et appareil pour commander des particules magnetiques a l'aide d'une machine de pipettage

Country Status (8)

Country Link
US (1) US6509193B1 (fr)
EP (1) EP0965842B1 (fr)
JP (1) JP3682302B2 (fr)
AU (1) AU738336B2 (fr)
CA (1) CA2255658C (fr)
DE (1) DE69638151D1 (fr)
NO (1) NO330495B1 (fr)
WO (1) WO1997044671A1 (fr)

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DE19823719A1 (de) * 1998-05-27 1999-12-16 Max Planck Gesellschaft Verfahren und Vorrichtung zum Prozessieren von Kleinstsubstanzmengen
JP2001296304A (ja) * 2000-04-13 2001-10-26 Aloka Co Ltd 分注装置及び方法
US6723510B2 (en) 1999-07-15 2004-04-20 Qiagen Gmbh Methods for separating particulate substrates from solution while minimizing particle loss
WO2004092710A1 (fr) * 2003-04-15 2004-10-28 Universal Bio Research Co., Ltd. Cylindre de distribution, dispositif de distribution grande capacite, et procede d'utilisation de ce dispositif
JP2005069830A (ja) * 2003-08-22 2005-03-17 Sysmex Corp 分注チップとそれを用いた分析装置
WO2006062235A1 (fr) 2004-12-10 2006-06-15 Universal Bio Research Co., Ltd. Puce renfermant un porteur d’immobilisation de biomatériau, appareil de traitement d’un porteur d’immobilisation de biomatériau et procédé de traitement idoine
WO2007145206A1 (fr) 2006-06-13 2007-12-21 Universal Bio Research Co., Ltd. Contenant transformable renfermant un véhicule, et dispositif et procédé de traitement de contenant transformable renfermant un véhicule
WO2007148734A1 (fr) 2006-06-20 2007-12-27 Hitachi Metals, Ltd. Particule métallique, perle métallique pour l'extraction de substances biologiques et leurs procédés de fabricaton
WO2008026670A1 (fr) * 2006-08-30 2008-03-06 Universal Bio Research Co., Ltd. Séparateur de microplaque et procédé de séparation de microplaque
JP2009288248A (ja) * 2008-05-30 2009-12-10 Grifols Sa ゲルカード上の試料を自動分析するための器械
US20090314802A1 (en) * 2003-06-19 2009-12-24 Abbott Laboratories Apparatus And Method For Handling Fluids For Analysis
WO2011059076A1 (fr) * 2009-11-13 2011-05-19 ユニバーサル・バイオ・リサーチ株式会社 Réactif magnétique, trousse de réactif magnétique, procédé permettant de traiter des supports magnétiques et dispositif de traitement associé
JP2011516075A (ja) * 2008-04-09 2011-05-26 バイオニア コーポレーション 自動精製装置、マルチウェルプレートキット及び生物学的試料からヘキサンを抽出する方法
JP2011107089A (ja) * 2009-11-20 2011-06-02 Hitachi High-Technologies Corp 液体混合方法及び分注装置
JPWO2010074265A1 (ja) * 2008-12-25 2012-06-21 ユニバーサル・バイオ・リサーチ株式会社 検体の前処理方法、および生体関連物質の測定方法
JP5122949B2 (ja) * 2005-05-19 2013-01-16 ユニバーサル・バイオ・リサーチ株式会社 分注量検出方法および吸液モニタ型分注装置
WO2013084969A1 (fr) * 2011-12-09 2013-06-13 Canon Kabushiki Kaisha Appareil d'analyse pour test de laboratoire
JP2013178285A (ja) * 2008-03-11 2013-09-09 Ortho-Clinical Diagnostics Inc ピペット先端部における粒子凝集
WO2014065221A1 (fr) 2012-10-22 2014-05-01 ユニバーサル・バイオ・リサーチ株式会社 Procédé d'analyse et trousse d'analyse pour quantifier ou détecter simultanément de multiples types de substances cible
US9260744B2 (en) 2005-09-05 2016-02-16 Universal Bio Research Co., Ltd. Various-substance holder, various-substance holder treating apparatus, and various-substance holder treating method
WO2016031705A1 (fr) * 2014-08-26 2016-03-03 ユニバーサル・バイオ・リサーチ株式会社 Appareil de commande de réaction de particules magnétiques utilisant un appareil de distribution à pas variable et procédé de commande de réaction pour celui-ci
US9662663B2 (en) 2014-12-22 2017-05-30 Shimadzu Corporation Magnetic particle manipulation apparatus
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NO990558L (no) 1999-02-05
JP3682302B2 (ja) 2005-08-10
NO990558D0 (no) 1999-02-05
AU738336B2 (en) 2001-09-13
NO330495B1 (no) 2011-05-02
EP0965842A1 (fr) 1999-12-22
CA2255658A1 (fr) 1997-11-27
US6509193B1 (en) 2003-01-21
EP0965842B1 (fr) 2010-03-17
EP0965842A4 (fr) 1999-12-22
CA2255658C (fr) 2007-07-17
AU5703096A (en) 1997-12-09

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