WO1997022266A1 - Adsorbens für phosphat aus wässrigem medium, dessen herstellung und verwendung - Google Patents
Adsorbens für phosphat aus wässrigem medium, dessen herstellung und verwendung Download PDFInfo
- Publication number
- WO1997022266A1 WO1997022266A1 PCT/EP1996/005695 EP9605695W WO9722266A1 WO 1997022266 A1 WO1997022266 A1 WO 1997022266A1 EP 9605695 W EP9605695 W EP 9605695W WO 9722266 A1 WO9722266 A1 WO 9722266A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- iron
- phosphate
- suspension
- adsorbent
- adsorbent according
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
- A23L5/273—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption using adsorption or absorption agents, resins, synthetic polymers, or ion exchangers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/015—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
Definitions
- Adsorbent for phosphate from an aqueous medium Adsorbent for phosphate from an aqueous medium, its production and use
- the invention relates to an adsorbent for phosphate from an aqueous medium, for example from aqueous solutions. It is particularly suitable as an adsorbent for inorganic and food-bound phosphate; in particular as a preparation for oral use for the prophylaxis and treatment of the hyperphosphatemic condition.
- Hyperparathyroidism must be considered one of the causes of the development of renal osteopathy. Usually one tries to check the phosphate balance by dialysis, administration of oral phosphate adsorbers, which should prevent the absorption of the food phosphates in the gastrointestinal tract, or the combination of both methods in the
- the aluminum III salts used as oral phosphate adsorbers in addition to the dialysis-encephalopathy syndrome, cause renal osteopathy and microcytic anemia.
- hypercalcaemia often occurs in connection with vascular and soft tissue calcification as well as gastrointestinal complaints (Dialyse Journal 37, 1-40 (1991).
- DE 42 39 442 A1 proposed the use of adsorption materials modified with polynuclear metal oxide hydroxides, the use of the water-soluble iron dextrans and dextrins described there having the disadvantage of being absorbable.
- crosslinked polysaccharide carriers complexes can be produced which release little iron.
- the disadvantage of these complexes, which are based on alpha iron hydroxides, lies on the one hand in the high cost of the crosslinked to be used
- the object of the present invention is therefore to provide adsorbents for phosphate from an aqueous medium, in particular from an aqueous solution.
- the adsorbents are said to be particularly suitable for inorganic and food-bound phosphate from body fluids, chyme and foods, have an improved phosphate adsorption capacity and be simple and inexpensive to produce.
- adsorbents for phosphate from an aqueous medium which form an object of the invention and which contain polynuclear beta-iron hydroxide stabilized by carbohydrates and / or humic acid.
- the adsorbents are particularly suitable for the adsorption of phosphates from aqueous solutions, for example for the adsorption of inorganic and food-bound phosphates.
- polynuclear beta-iron hydroxide has a superior phosphate adsorption capacity.
- stabilization can take place by means of suitable compounds, in particular carbohydrates and humic acid. Without being bound by any theory, it is assumed that there is no complex formation with the carbohydrates.
- Another object of the invention is the method for
- polynuclear beta-iron hydroxide stabilized by carbohydrates and / or humic acid which can be used as an adsorbent or in adsorbents for inorganic and food-bound phosphate.
- an aqueous base solution containing an aqueous chloride ion is used
- Sodium carbonate or sodium bicarbonate in aqueous solution for example, can be used as the alkali carbonate or alkali bicarbonate solution.
- Water-soluble salts of, for example, inorganic or organic acids can be used as the iron (III) salt; iron (III) chloride is preferred.
- ⁇ -iron hydroxide (Akaganeit) is fundamentally known in the prior art and is described, for example, in the reference U. Schwertmann, RM Cornell “Iron Oxides in the Laboratory", VCH Verlagsgesellschaft mbH, 1991, pages 95-100.
- ferrihydrite is also precipitated.
- Such mixtures of ⁇ -iron hydroxide and ferrihydrite can also be used as adsorbents in the present invention and are therefore also an object of the present invention.
- One or more carbohydrates and / or humic acid are added to the suspension obtained above.
- Water-soluble compounds are preferably used.
- the carbohydrates and / or humic acid can be added in solid form, whereby they can dissolve in the water present. However, it is also possible to add aqueous carbohydrate solutions.
- the amount of carbohydrates or humic acid so that at least 0.5 g carbohydrate or humic acid are added per g iron (calculated as Fe).
- the iron content should not exceed 40 percent by weight.
- the maximum content of carbohydrates and / or humic acid is not subject to any limits and is primarily determined by economic reasons.
- Soluble carbohydrates such as various sugars, e.g. Agarose, dextran, dextrin, dextran derivatives, cellulose and cellulose derivatives, sucrose, maltose, lactose or mannitol.
- the adsorption materials made of insoluble stabilized polynuclear beta-iron hydroxide provided according to the invention have the advantage that they release little iron in addition to a high phosphate binding capacity and are inexpensive to produce.
- Calcium salts include, for example, salts of inorganic or organic acids, in particular calcium acetate.
- the addition of the calcium salt increases the phosphate binding capacity, especially at higher pH values. It is particularly convenient to use such
- Use calcium salts provided adsorbents at pH values of more than 5, since even then the complete phosphate binding capacity is retained.
- the adsorbents according to the invention can be formulated, for example, for oral use. They can be formulated as such or together with customary pharmaceutical additives, such as customary carriers or auxiliaries. For example, an encapsulation can take place, it being possible to use conventional materials used in the pharmaceutical sector as encapsulation agents. It is also possible to provide the adsorbents, optionally together with auxiliaries and additives, in the form of granules, tablets, coated tablets or, for example, in sachets.
- the daily dose of the adsorbents according to the invention is, for example, 1 to 3 g, preferably approximately 1.5 g, of iron.
- adsorbents of the invention are also suitable for use in the adsorption of food-borne phosphate; for this purpose, they can be added to foods, for example.
- formulations can be created, for example, as described above for medicinal products.
- sucrose and starch 15 g are added to each of the 208.3 g of the above suspension.
- the suspension is then concentrated on a rotary evaporator at 50 ° C. and dried at 40 ° C. in a high vacuum. 47.2 g of powder with an iron content of 21.2% (complexometrically determined) are obtained.
- Example 2 30.0 g of sucrose are added to 208.3 g of the suspension prepared according to Example 1. The resulting suspension is then concentrated on a rotary evaporator at 50 ° C. and dried at 40 ° C. in a high vacuum. The phosphate binding capacity of the resulting material is determined analogously to Example 2:
- Example 2 30.0 g of white dextrin (Amylum, from Blattmann) are added to 208.3 g of the suspension prepared according to Example 1. The resulting suspension is then concentrated on a rotary evaporator at 50 ° C. and dried at 40 ° C. in a high vacuum. The phosphate binding capacity of the resulting material is determined analogously to Example 2:
- Example 2 30.0 g of humic acid (Fluka, Art. No. 53860) are added to 208.3 g of the suspension prepared according to Example 1. The resulting suspension is then concentrated on a rotary evaporator at 50 ° C. and dried at 40 ° C. in a high vacuum. The phosphate binding capacity of the resulting material is determined analogously to Example 2:
- iron (III) oxide corresponding to 50 mg of iron (corresponding to 0.9 mmol of iron
- 10 ml of sodium phosphate solution 13.68 g / 1 Na 3 P0 4 x 12 H 2 0
- the phosphate binding capacity is determined analogously to the example
- the phosphate binding capacity is determined analogously to Example 10:
- Example 16 To produce a standard rat feed with 0.8% total phosphorus content, the dry, powdery individual components were filled into a cylinder after thorough mixing and pressed into pellets. The composition of the feed according to the Weender analysis corresponded to the values in the table below. The total phosphorus content was divided between 0.75% organically bound and 0.05% inorganic phosphate.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Water Treatment By Sorption (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK96944004T DK0868125T3 (da) | 1995-12-19 | 1996-12-19 | Adsorbens for phosphat fra vandigt medium, dets fremstilling og anvendelse |
EP96944004A EP0868125B1 (de) | 1995-12-19 | 1996-12-19 | Adsorbens für phosphat aus wässrigem medium, dessen herstellung und verwendung |
AT96944004T ATE207707T1 (de) | 1995-12-19 | 1996-12-19 | Adsorbens für phosphat aus wässrigem medium, dessen herstellung und verwendung |
KR10-1998-0704632A KR100390481B1 (ko) | 1995-12-19 | 1996-12-19 | 수용성매체로부터인산염을흡착하기위한흡착제및이의제조방법 |
BRPI9612138A BRPI9612138B8 (pt) | 1995-12-19 | 1996-12-19 | adsorvente para fosfato a partir de meio aquoso. |
AU13747/97A AU1374797A (en) | 1995-12-19 | 1996-12-19 | Adsorbent for phosphate from an aqueous medium, production and use of said adsorbent |
CA002240668A CA2240668C (en) | 1995-12-19 | 1996-12-19 | Adsorbent for phosphate from an aqueous medium, production and use of said adsorbent thereof |
JP52250797A JP3665345B2 (ja) | 1995-12-19 | 1996-12-19 | 水性媒質からのリン酸塩に対する吸着剤、その製造および使用 |
US09/077,944 US6174442B1 (en) | 1995-12-19 | 1996-12-19 | Adsorbent for phosphate from an aqueous medium, production and use of said adsorbent |
SI9630402T SI0868125T1 (en) | 1995-12-19 | 1996-12-19 | Adsorbent for phosphate from an aqueous medium, production and use of said adsorbent |
BRPI9612138-6A BR9612138B1 (pt) | 1995-12-19 | 1996-12-19 | adsorvente para fosfato a partir de meio aquoso. |
DE59608089T DE59608089D1 (de) | 1995-12-19 | 1996-12-19 | Adsorbens für phosphat aus wässrigem medium, dessen herstellung und verwendung |
NO19982722A NO314382B1 (no) | 1995-12-19 | 1998-06-12 | Absorbenter for fosfat fra et vandig medium, samt fremgangsmåte ved fremstilling og anvendelse av absorbenten |
LTPA2015003C LTC0868125I2 (lt) | 1995-12-19 | 2015-01-21 | Adsorbentas fosfato adsorbavimui iš vandeninės terpės, to adsorbento gavimas ir panaudojimas |
NO2015004C NO2015004I1 (no) | 1995-12-19 | 2015-02-17 | Blanding av polynukleært jern(III)oksyhydroksid, sukrose og stivelser |
FR15C0018C FR15C0018I2 (fr) | 1995-12-19 | 2015-02-25 | Adsorbants pour phosphates formes a partir d'agents aqueux, leur production et leur utilisation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19547356.6 | 1995-12-19 | ||
DE19547356A DE19547356A1 (de) | 1995-12-19 | 1995-12-19 | Adsorbens für Phosphat aus wäßrigem Medium, dessen Herstellung und Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997022266A1 true WO1997022266A1 (de) | 1997-06-26 |
Family
ID=7780518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1996/005695 WO1997022266A1 (de) | 1995-12-19 | 1996-12-19 | Adsorbens für phosphat aus wässrigem medium, dessen herstellung und verwendung |
Country Status (23)
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1999015189A1 (en) * | 1997-09-19 | 1999-04-01 | Crosfield Limited | Metal compounds, mixed or sulphated, as phosphate binders |
WO2006000547A2 (de) * | 2004-06-28 | 2006-01-05 | Vifor (International) Ag | Verfahren zur herstellung eines phosphatadsorbens auf eisensulfat-basis |
EP1932807A1 (en) * | 2006-12-14 | 2008-06-18 | Novartis AG | Inorganic compounds |
EP1932808A1 (en) * | 2006-12-14 | 2008-06-18 | Novartis AG | Iron(III)-Carbohydrate based phosphate adsorbent |
WO2008071747A1 (en) * | 2006-12-14 | 2008-06-19 | Novartis Ag | Iron (iii)-carbohydrate based phosphate adsorbent |
WO2009150232A2 (en) * | 2008-06-13 | 2009-12-17 | Novartis Ag | Manufacture process for the preparation of an iron containing phosphate adsorbent |
US9066917B2 (en) | 2009-08-03 | 2015-06-30 | Cytochroma Development Inc. | Mixed metal compound |
US9168270B2 (en) | 2006-01-31 | 2015-10-27 | Opko Ireland Global Holdings, Ltd. | Water-insoluble, iron-containing mixed metal, granular material |
DE102014019388A1 (de) | 2014-12-29 | 2016-06-30 | Susanne Wagner | Arzneimittel auf der Basis von Maghämit zur gleichzeitigen Reduzierung der gastrointestinalen Natriumresorption und Phosphatresorption |
US9387191B2 (en) | 2009-07-21 | 2016-07-12 | Keryx Biopharmaceuticals, Inc. | Ferric citrate dosage forms |
US9566302B2 (en) | 2010-02-04 | 2017-02-14 | Opko Ireland Global Holdings, Ltd. | Composition comprising mixed metal compounds and xanthan gum |
US9796792B2 (en) | 2013-03-08 | 2017-10-24 | Vidasym, Inc. | Metal ion-functional fiber component complex compositions, preparation and uses thereof |
RU2648760C2 (ru) * | 2007-11-16 | 2018-03-28 | Вифор (Интернациональ) Аг | Фармацевтическая композиция, содержащая оксигидроксид железа, способ ее получения и применение |
US10155040B2 (en) | 2007-10-16 | 2018-12-18 | Opko Ireland Global Holdings, Ltd. | Mixed metal compounds for treatment of hyperphosphataemia |
US10201501B2 (en) | 2007-07-27 | 2019-02-12 | Opko Ireland Global Holdings, Ltd. | Mixed metal compounds used as antacids |
WO2020165781A1 (en) * | 2019-02-12 | 2020-08-20 | Biophore India Pharmaceuticals Pvt. Ltd | "improved process for the preparation of sucroferric oxyhydroxide" |
EP3735962A1 (en) | 2013-11-27 | 2020-11-11 | Vifor (International) AG | Pharmaceutical composition, comprising phosphate binder particles |
WO2022003016A1 (en) | 2020-07-01 | 2022-01-06 | Vifor Fresenius Medical Care Renal Pharma, Ltd. | Manufacturing method for polynuclear iron compounds stabilized by carbohydrates and/or humic acid |
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DE19853529A1 (de) * | 1998-11-20 | 2000-05-25 | Dieter A Hiller | Regenwasserabfluß-Schadstofffilter |
JPWO2003053565A1 (ja) * | 2001-12-21 | 2005-04-28 | 室町ケミカル株式会社 | リン酸の吸着剤 |
US7955616B2 (en) * | 2003-09-23 | 2011-06-07 | Orthocon, Inc. | Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects |
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US20060169014A1 (en) * | 2005-01-31 | 2006-08-03 | Laboratorios Diet-Esthetic, S.A. | Composition for the nutrition and irrigation of plants |
WO2006134828A1 (ja) * | 2005-06-09 | 2006-12-21 | Tomotaka Yanagita | アニオン吸着剤、水質又は土壌浄化剤及びそれらの製造方法 |
GB2430793A (en) * | 2005-09-29 | 2007-04-04 | Bookham Technology Plc | Bragg grating reflection strength control |
ITRM20060204A1 (it) * | 2006-04-10 | 2007-10-11 | Vincenzo Savica | Farmaci e alimentei per diete normoproteiche iperproteiche ipopro teiche tutte ipofosforiche e bevande ipofosforiche |
US20090280191A1 (en) * | 2006-06-29 | 2009-11-12 | J-Pharma Co., Ltd. | Preventive remedial therapeutic agent for phosphorus impairment, oral agent for adsorbing phosphate ion contained in food, beverage and chemical, and process for producing them |
DE102006055757B4 (de) | 2006-11-25 | 2012-03-15 | Continental Teves Ag & Co. Ohg | Selbstpumpende Niveauregulierung |
US7927493B2 (en) * | 2007-05-11 | 2011-04-19 | Ch2M Hill, Inc. | Low phosphorus water treatment methods |
US9101716B2 (en) | 2008-02-01 | 2015-08-11 | Baxter International Inc. | Multi-pass dialysis |
GB0814326D0 (en) * | 2008-08-05 | 2008-09-10 | Medical Res Council | Phosphate binding materials and their uses |
CN102341111A (zh) * | 2009-03-02 | 2012-02-01 | 维福(国际)股份公司 | 磷酸盐吸附剂 |
US8721887B2 (en) | 2009-12-07 | 2014-05-13 | Ch2M Hill, Inc. | Method and system for treating wastewater |
EP2548562A1 (de) | 2011-07-18 | 2013-01-23 | SeBo GmbH | Kombinationstherapie mit Eisen-basierenden Phosphatadsorbern |
AU2013201308B2 (en) * | 2011-10-13 | 2015-01-29 | Alebund Pharmaceuticals (Hong Kong) Limited | Iron-fiber composition, preparation and uses thereof |
RU2496722C1 (ru) * | 2012-04-10 | 2013-10-27 | Леонид Асхатович Мазитов | Способ очистки сточной воды от фосфатов |
WO2015181205A1 (en) | 2014-05-28 | 2015-12-03 | Biaqua B.V. | Method for removing phosphate from water fractions |
EP3157516A4 (en) | 2014-06-22 | 2017-12-13 | Dexcel Pharma Technologies Ltd. | Pharmaceutical compositions comprising ferric citrate and methods for the production thereof |
EP3191219A1 (en) | 2014-09-10 | 2017-07-19 | Lupin Limited | A manufacturing process for an iron containing adsorbent |
KR101609802B1 (ko) | 2015-02-09 | 2016-04-06 | 광주과학기술원 | 아카가나이트 분말이 고정화된 수중 산소산 음이온 제거 및 회수용 입상 흡착제 및 그 제조방법 |
WO2017061118A1 (ja) * | 2015-10-09 | 2017-04-13 | 高橋金属株式会社 | 陰イオン吸着方法 |
WO2020025552A1 (en) | 2018-07-30 | 2020-02-06 | Interquim, S.A. | Process for preparing an adsorbent for phosphate in aqueous medium |
SG11202109323UA (en) * | 2019-02-28 | 2021-09-29 | Renibus Therapeutics Inc | Novel iron compositions and methods of making and using the same |
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FR2387045A1 (fr) * | 1977-04-12 | 1978-11-10 | Organon Teknika Bv | Dispositif muni d'un agent de sorption pour purifier le sang, agent de sorption approprie a l'emploi oral et procede pour preparer l'agent de sorption |
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US5411569A (en) * | 1991-08-28 | 1995-05-02 | Kemiron, Inc. | Iron humate product |
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1995
- 1995-12-19 DE DE19547356A patent/DE19547356A1/de not_active Withdrawn
-
1996
- 1996-12-10 AR ARP960105596A patent/AR005026A1/es active IP Right Grant
- 1996-12-10 TW TW085115264A patent/TW457090B/zh not_active IP Right Cessation
- 1996-12-17 IN IN2177CA1996 patent/IN190206B/en unknown
- 1996-12-18 ZA ZA9610643A patent/ZA9610643B/xx unknown
- 1996-12-19 CA CA002240668A patent/CA2240668C/en not_active Expired - Lifetime
- 1996-12-19 SI SI9630402T patent/SI0868125T1/xx unknown
- 1996-12-19 US US09/077,944 patent/US6174442B1/en not_active Expired - Lifetime
- 1996-12-19 ES ES96944004T patent/ES2171758T3/es not_active Expired - Lifetime
- 1996-12-19 BR BRPI9612138-6A patent/BR9612138B1/pt active IP Right Grant
- 1996-12-19 DK DK96944004T patent/DK0868125T3/da active
- 1996-12-19 TR TR1998/01152T patent/TR199801152T2/xx unknown
- 1996-12-19 PT PT96944004T patent/PT868125E/pt unknown
- 1996-12-19 AT AT96944004T patent/ATE207707T1/de active
- 1996-12-19 EP EP96944004A patent/EP0868125B1/de not_active Expired - Lifetime
- 1996-12-19 BR BRPI9612138A patent/BRPI9612138B8/pt unknown
- 1996-12-19 DE DE59608089T patent/DE59608089D1/de not_active Expired - Lifetime
- 1996-12-19 WO PCT/EP1996/005695 patent/WO1997022266A1/de active IP Right Grant
- 1996-12-19 KR KR10-1998-0704632A patent/KR100390481B1/ko not_active IP Right Cessation
- 1996-12-19 JP JP52250797A patent/JP3665345B2/ja not_active Expired - Lifetime
- 1996-12-19 AU AU13747/97A patent/AU1374797A/en not_active Abandoned
-
1998
- 1998-06-12 NO NO19982722A patent/NO314382B1/no not_active IP Right Cessation
-
2014
- 2014-12-24 LU LU92626C patent/LU92626I2/xx unknown
-
2015
- 2015-01-21 LT LTPA2015003C patent/LTC0868125I2/lt unknown
- 2015-02-17 NO NO2015004C patent/NO2015004I1/no not_active IP Right Cessation
- 2015-02-25 FR FR15C0018C patent/FR15C0018I2/fr active Active
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Cited By (38)
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WO1999015189A1 (en) * | 1997-09-19 | 1999-04-01 | Crosfield Limited | Metal compounds, mixed or sulphated, as phosphate binders |
US6926912B1 (en) | 1997-09-19 | 2005-08-09 | Ineos Silicas Limited | Metal compounds, mixed or sulphated, as phosphate binders |
EP1759704A3 (en) * | 1997-09-19 | 2007-08-15 | Ineos Healthcare Limited | Metal compounds, mixed or sulphated, as phosphate binders |
US9242869B2 (en) | 1997-09-19 | 2016-01-26 | Opko Ireland Global Holdings, Ltd. | Metal compounds mixed or sulphated, as phosphate binders |
US7799351B2 (en) | 1997-09-19 | 2010-09-21 | Ineos Healthcare Limited | Metal compounds, mixed or sulphated, as phosphate binders |
WO2006000547A2 (de) * | 2004-06-28 | 2006-01-05 | Vifor (International) Ag | Verfahren zur herstellung eines phosphatadsorbens auf eisensulfat-basis |
WO2006000547A3 (de) * | 2004-06-28 | 2006-06-22 | Vifor Int Ag | Verfahren zur herstellung eines phosphatadsorbens auf eisensulfat-basis |
US9907816B2 (en) | 2006-01-31 | 2018-03-06 | Opko Ireland Global Holdings, Ltd. | Water-insoluble, iron-containing mixed metal, granular material |
US9168270B2 (en) | 2006-01-31 | 2015-10-27 | Opko Ireland Global Holdings, Ltd. | Water-insoluble, iron-containing mixed metal, granular material |
WO2008071747A1 (en) * | 2006-12-14 | 2008-06-19 | Novartis Ag | Iron (iii)-carbohydrate based phosphate adsorbent |
EP1932808A1 (en) * | 2006-12-14 | 2008-06-18 | Novartis AG | Iron(III)-Carbohydrate based phosphate adsorbent |
US8252310B2 (en) | 2006-12-14 | 2012-08-28 | Novartis Ag | Manufacture process |
EP2918548A1 (en) * | 2006-12-14 | 2015-09-16 | Novartis Tiergesundheit AG | Iron(iii) sugar based phosphate adsorbent |
EP1932807A1 (en) * | 2006-12-14 | 2008-06-18 | Novartis AG | Inorganic compounds |
US10201501B2 (en) | 2007-07-27 | 2019-02-12 | Opko Ireland Global Holdings, Ltd. | Mixed metal compounds used as antacids |
US10155040B2 (en) | 2007-10-16 | 2018-12-18 | Opko Ireland Global Holdings, Ltd. | Mixed metal compounds for treatment of hyperphosphataemia |
US11013762B1 (en) | 2007-11-16 | 2021-05-25 | Vifor Fresenius Medical Care Renal Pharma Ltd. | Pharmaceutical compositions |
US10925896B2 (en) | 2007-11-16 | 2021-02-23 | Vifor Fresenius Medical Care Renal Pharma Ltd | Pharmaceutical compositions |
US10780113B2 (en) | 2007-11-16 | 2020-09-22 | Vifor Fresenius Medical Care Renal Pharma Ltd. | Pharmaceutical compositions |
US10695367B2 (en) | 2007-11-16 | 2020-06-30 | Vifor Fresenius Medical Care Renal Pharma Ltd | Pharmaceutical compositions |
US10682376B2 (en) | 2007-11-16 | 2020-06-16 | Vifor Fresenius Medical Care Renal Pharma Ltd | Pharmaceutical compositions |
US10925897B2 (en) | 2007-11-16 | 2021-02-23 | Vifor Fresenius Medical Care Renal Pharma Ltd | Pharmaceutical compositions |
US11013761B1 (en) | 2007-11-16 | 2021-05-25 | Vifor Fresenius Medical Care Renal Pharma Ltd. | Pharmaceutical compositions |
RU2648760C2 (ru) * | 2007-11-16 | 2018-03-28 | Вифор (Интернациональ) Аг | Фармацевтическая композиция, содержащая оксигидроксид железа, способ ее получения и применение |
WO2009150232A3 (en) * | 2008-06-13 | 2010-02-04 | Novartis Ag | Manufacture process for the preparation of an iron containing phosphate adsorbent |
WO2009150232A2 (en) * | 2008-06-13 | 2009-12-17 | Novartis Ag | Manufacture process for the preparation of an iron containing phosphate adsorbent |
US9387191B2 (en) | 2009-07-21 | 2016-07-12 | Keryx Biopharmaceuticals, Inc. | Ferric citrate dosage forms |
US10300039B2 (en) | 2009-07-21 | 2019-05-28 | Keryx Biopharmaceuticals, Inc. | Ferric citrate dosage forms |
US9314481B2 (en) | 2009-08-03 | 2016-04-19 | Opko Ireland Global Holdings, Ltd. | Method |
US9066917B2 (en) | 2009-08-03 | 2015-06-30 | Cytochroma Development Inc. | Mixed metal compound |
US9566302B2 (en) | 2010-02-04 | 2017-02-14 | Opko Ireland Global Holdings, Ltd. | Composition comprising mixed metal compounds and xanthan gum |
US9796792B2 (en) | 2013-03-08 | 2017-10-24 | Vidasym, Inc. | Metal ion-functional fiber component complex compositions, preparation and uses thereof |
EP3735962A1 (en) | 2013-11-27 | 2020-11-11 | Vifor (International) AG | Pharmaceutical composition, comprising phosphate binder particles |
EP3741360A1 (en) | 2013-11-27 | 2020-11-25 | Vifor (International) AG | Pharmaceutical composition, comprising phosphate binder particles |
WO2016107619A1 (de) | 2014-12-29 | 2016-07-07 | Susanne Wagner | Arzneimittel auf der basis von maghämit zur gleichzeitigen reduzierung der gastrointestinalen natriumresorption und phosphatresorption |
DE102014019388A1 (de) | 2014-12-29 | 2016-06-30 | Susanne Wagner | Arzneimittel auf der Basis von Maghämit zur gleichzeitigen Reduzierung der gastrointestinalen Natriumresorption und Phosphatresorption |
WO2020165781A1 (en) * | 2019-02-12 | 2020-08-20 | Biophore India Pharmaceuticals Pvt. Ltd | "improved process for the preparation of sucroferric oxyhydroxide" |
WO2022003016A1 (en) | 2020-07-01 | 2022-01-06 | Vifor Fresenius Medical Care Renal Pharma, Ltd. | Manufacturing method for polynuclear iron compounds stabilized by carbohydrates and/or humic acid |
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