WO1997004750A3 - Procede de preparation de formes galeniques solides de medicaments en tres faibles doses - Google Patents

Procede de preparation de formes galeniques solides de medicaments en tres faibles doses Download PDF

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Publication number
WO1997004750A3
WO1997004750A3 PCT/EP1996/003326 EP9603326W WO9704750A3 WO 1997004750 A3 WO1997004750 A3 WO 1997004750A3 EP 9603326 W EP9603326 W EP 9603326W WO 9704750 A3 WO9704750 A3 WO 9704750A3
Authority
WO
WIPO (PCT)
Prior art keywords
low
dosage forms
solid dosage
preparing solid
dose drugs
Prior art date
Application number
PCT/EP1996/003326
Other languages
English (en)
Other versions
WO1997004750A2 (fr
Inventor
James Albert Napper
Neil Mortimer
Karen Triona O'brien
Sultan James Manek
Rajinder Kumar
Michael Sidney George Clark
Julia Mary Loudon
Original Assignee
Smithkline Beecham Plc
James Albert Napper
Neil Mortimer
Brien Karen Triona O
Sultan James Manek
Rajinder Kumar
Michael Sidney George Clark
Julia Mary Loudon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515624.6A external-priority patent/GB9515624D0/en
Priority claimed from GBGB9606684.0A external-priority patent/GB9606684D0/en
Priority to JP9507243A priority Critical patent/JPH11510493A/ja
Priority to MX9800809A priority patent/MX9800809A/es
Priority to IL12289796A priority patent/IL122897A0/xx
Priority to APAP/P/1998/001170A priority patent/AP858A/en
Priority to EP96927621A priority patent/EP0841902A2/fr
Priority to AU67384/96A priority patent/AU716961B2/en
Application filed by Smithkline Beecham Plc, James Albert Napper, Neil Mortimer, Brien Karen Triona O, Sultan James Manek, Rajinder Kumar, Michael Sidney George Clark, Julia Mary Loudon filed Critical Smithkline Beecham Plc
Priority to EA199901055A priority patent/EA199901055A1/ru
Priority to EA199800179A priority patent/EA000740B1/ru
Priority to BR9609804A priority patent/BR9609804A/pt
Priority to IL14957996A priority patent/IL149579A0/xx
Priority to SK110-98A priority patent/SK11098A3/sk
Priority to NZ315632A priority patent/NZ315632A/xx
Publication of WO1997004750A2 publication Critical patent/WO1997004750A2/fr
Publication of WO1997004750A3 publication Critical patent/WO1997004750A3/fr
Priority to NO980384A priority patent/NO980384L/no
Priority to BG102266A priority patent/BG102266A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Cette invention concerne un procédé de formulation d'un médicament qui consiste à mélanger des particules d'excipient à une solution aqueuse contenant un médicament, ladite solution représentant de 1 à 3 % en poids du mélange total. L'invention concerne également un procédé de traitement et/ou de prophylaxie de la démence qui consiste à administrer à un patient du monochlorhydrate de [R-(Z)]-α-(méthoxyimino)-α-(1-azabicyclo[2.2.2]oct-3-yl)acétonitrile en une dose quotidienne ne dépassant pas 0,01mg/kg, ainsi que les compositions pharmaceutiques utilisées dans ce type de traitement.
PCT/EP1996/003326 1995-07-29 1996-07-29 Procede de preparation de formes galeniques solides de medicaments en tres faibles doses WO1997004750A2 (fr)

Priority Applications (14)

Application Number Priority Date Filing Date Title
SK110-98A SK11098A3 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs
NZ315632A NZ315632A (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs comprising admixing 1-3% by weight of carrier particles with a solution of drug in water
BR9609804A BR9609804A (pt) 1995-07-29 1996-07-29 Processo para a preparação de formas farmacéuticas sólidas com drogas de dosagens muíto baixas
IL12289796A IL122897A0 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs
APAP/P/1998/001170A AP858A (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs.
EP96927621A EP0841902A2 (fr) 1995-07-29 1996-07-29 Procede de preparation de formes galeniques solides de medicaments en tres faibles doses
AU67384/96A AU716961B2 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs
JP9507243A JPH11510493A (ja) 1995-07-29 1996-07-29 非常に低用量の薬剤の固形剤形の製造方法
EA199901055A EA199901055A1 (ru) 1995-07-29 1996-07-29 Фармацевтическая композиция для лечения и/или профилактики деменции
EA199800179A EA000740B1 (ru) 1995-07-29 1996-07-29 Способ получения твердого терапевтически активного лекарственного средства, содержащего лекарство в малых дозах, и лекарственное средство, полученное этим способом
MX9800809A MX9800809A (es) 1995-07-29 1996-07-29 Procedimiento para preparar formas de dosis solidas de dosis muy bajas del farmaco.
IL14957996A IL149579A0 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of low-dose drugs
NO980384A NO980384L (no) 1995-07-29 1998-01-28 Fremgangsmåte for fremstilling av fastdoseformer av svært lav-dose legemidler
BG102266A BG102266A (en) 1995-07-29 1998-02-20 Method for the preparation of solid batched forms having very low doses of the medicamentous form

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9515624.6 1995-07-29
GBGB9515624.6A GB9515624D0 (en) 1995-07-29 1995-07-29 Novel process
GBGB9606684.0A GB9606684D0 (en) 1996-03-29 1996-03-29 Novel process
GB9606684.0 1996-03-29

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09000252 A-371-Of-International 1998-07-08
US09/759,575 Continuation US20010018074A1 (en) 1995-07-29 2001-01-12 Process for preparing solid dosage forms of very low-dose drugs

Publications (2)

Publication Number Publication Date
WO1997004750A2 WO1997004750A2 (fr) 1997-02-13
WO1997004750A3 true WO1997004750A3 (fr) 1997-03-27

Family

ID=26307485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/003326 WO1997004750A2 (fr) 1995-07-29 1996-07-29 Procede de preparation de formes galeniques solides de medicaments en tres faibles doses

Country Status (25)

Country Link
EP (1) EP0841902A2 (fr)
JP (1) JPH11510493A (fr)
KR (1) KR19990035972A (fr)
CN (1) CN1196677A (fr)
AP (1) AP858A (fr)
AR (1) AR004178A1 (fr)
AU (1) AU716961B2 (fr)
BG (1) BG102266A (fr)
BR (1) BR9609804A (fr)
CA (1) CA2228048A1 (fr)
CZ (1) CZ24798A3 (fr)
DZ (1) DZ2077A1 (fr)
EA (2) EA000740B1 (fr)
HU (1) HUP9900521A3 (fr)
IL (1) IL122897A0 (fr)
MA (1) MA23953A1 (fr)
MX (1) MX9800809A (fr)
NO (1) NO980384L (fr)
NZ (1) NZ315632A (fr)
OA (1) OA10659A (fr)
PL (1) PL325242A1 (fr)
SK (1) SK11098A3 (fr)
TR (1) TR199800156T1 (fr)
UY (1) UY24297A1 (fr)
WO (1) WO1997004750A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619074D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Composition
HUP0101043A3 (en) 1998-03-11 2002-02-28 Smithkline Beecham Corp Controlled release oral dosage form containing [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2]oct-3-yl]acetonitrile monohydrochlorid and process for its preparation
FR2796840B1 (fr) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques Comprimes faiblement doses et procede de preparation
UA77404C2 (en) 2000-12-14 2006-12-15 Ortho Mcneil Pharm Inc Norgestimate-based steroid hormone product and method for its manufacture
WO2005097076A2 (fr) * 2004-04-09 2005-10-20 Smithkline Beecham Corporation Produits pharmaceutiques a faibles doses

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5970614A (ja) * 1982-10-14 1984-04-21 Asahi Chem Ind Co Ltd 微量主薬系湿式固形製剤方法
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
US4898736A (en) * 1988-03-09 1990-02-06 Merck & Co., Inc. Method for tablet preparation
EP0392803A1 (fr) * 1989-04-13 1990-10-17 Beecham Group p.l.c. Composés chimiques
WO1995017168A1 (fr) * 1993-12-21 1995-06-29 Applied Analytical Industries, Inc. Procede de preparation de produits pharmaceutiques a faible dosage

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
JPS5970614A (ja) * 1982-10-14 1984-04-21 Asahi Chem Ind Co Ltd 微量主薬系湿式固形製剤方法
US4898736A (en) * 1988-03-09 1990-02-06 Merck & Co., Inc. Method for tablet preparation
EP0392803A1 (fr) * 1989-04-13 1990-10-17 Beecham Group p.l.c. Composés chimiques
WO1995017168A1 (fr) * 1993-12-21 1995-06-29 Applied Analytical Industries, Inc. Procede de preparation de produits pharmaceutiques a faible dosage

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 101, no. 8, 20 August 1984, Columbus, Ohio, US; abstract no. 60165, XP002024576 *

Also Published As

Publication number Publication date
KR19990035972A (ko) 1999-05-25
HUP9900521A3 (en) 2001-04-28
IL122897A0 (en) 1998-08-16
CA2228048A1 (fr) 1997-02-13
AU6738496A (en) 1997-02-26
NZ315632A (en) 1999-11-29
AU716961B2 (en) 2000-03-09
TR199800156T1 (xx) 1998-04-21
CZ24798A3 (cs) 1998-06-17
UY24297A1 (es) 1997-01-23
AP9801170A0 (en) 1998-01-31
HUP9900521A2 (hu) 1999-06-28
NO980384L (no) 1998-03-26
JPH11510493A (ja) 1999-09-14
BR9609804A (pt) 1999-07-06
EA199901055A1 (ru) 2000-06-26
BG102266A (en) 1998-10-30
EA199800179A1 (ru) 1998-10-29
EA000740B1 (ru) 2000-02-28
EP0841902A2 (fr) 1998-05-20
MA23953A1 (fr) 1997-04-01
WO1997004750A2 (fr) 1997-02-13
AR004178A1 (es) 1998-11-04
DZ2077A1 (fr) 2002-07-22
CN1196677A (zh) 1998-10-21
PL325242A1 (en) 1998-07-06
SK11098A3 (en) 1998-07-08
MX9800809A (es) 1998-04-30
OA10659A (en) 2002-09-18
AP858A (en) 2000-07-12
NO980384D0 (no) 1998-01-28

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