RO116343B1 - Compoziţie farmaceutică şi metodă de tratament a infecţiilor bacteriene la pacienţi pediatrici - Google Patents

Compoziţie farmaceutică şi metodă de tratament a infecţiilor bacteriene la pacienţi pediatrici

Info

Publication number
RO116343B1
RO116343B1 RO97-01995A RO9701995A RO116343B1 RO 116343 B1 RO116343 B1 RO 116343B1 RO 9701995 A RO9701995 A RO 9701995A RO 116343 B1 RO116343 B1 RO 116343B1
Authority
RO
Romania
Prior art keywords
amoxycillin
clavulanic acid
pharmaceutical composition
bacterial infections
treating bacterial
Prior art date
Application number
RO97-01995A
Other languages
English (en)
Inventor
Richard Peregrine Bax
Mike Gale Ramsey
Original Assignee
Smithkline Beecham Plc
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26306975&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO116343(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9508989.2A external-priority patent/GB9508989D0/en
Priority claimed from GBGB9523655.0A external-priority patent/GB9523655D0/en
Application filed by Smithkline Beecham Plc, Smithkline Beecham Corporation filed Critical Smithkline Beecham Plc
Publication of RO116343B1 publication Critical patent/RO116343B1/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compoziţia farmaceutică, conform invenţiei, este adaptată pentru administrare orală, pediatrică, şi cuprinde amoxicilină trihidrat şi clavulanat de potasiu, în combinaţie, într-un raport în greutateîntre 6:1 şi 8:1, greutăţile fiind exprimate ca acizi parentali amoxicilină liberi şi acid clavulanic şi care, când se reconstituie, cuprinde amoxicilină într-o cantitate de la 150 . 450 mg/5 ml suspensie lichidă şi acid clavulanic într-o cantitate de la 25 la 75 mg/5 ml suspensie lichidă apoasă. Metoda de tratament a infecţiilor bacteriene la pacienţi pediatrici, conform invenţiei, constă în aceea că se administrează o compoziţie formată din amoxicilină trihidrat şi clavulanat de potasiu în raport de greutate cuprins între 6:1 şi 8:1, greutăţile fiind exprimate ca acizi parentali liberi, amoxicilină şi acid clavulanic, de două ori zilnic, la un dozaj de la 20 la 70 mg/kg/zi de amoxicilină şi cantităţile pe doză de acid clavulanic.
RO97-01995A 1995-05-03 1996-05-02 Compoziţie farmaceutică şi metodă de tratament a infecţiilor bacteriene la pacienţi pediatrici RO116343B1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9508989.2A GB9508989D0 (en) 1995-05-03 1995-05-03 Pharmaceutical formulations
GBGB9523655.0A GB9523655D0 (en) 1995-11-18 1995-11-18 Method of treatment
PCT/EP1996/001881 WO1996034605A1 (en) 1995-05-03 1996-05-02 Composition comprising amoxycillin and clavulanic acid

Publications (1)

Publication Number Publication Date
RO116343B1 true RO116343B1 (ro) 2001-01-30

Family

ID=26306975

Family Applications (1)

Application Number Title Priority Date Filing Date
RO97-01995A RO116343B1 (ro) 1995-05-03 1996-05-02 Compoziţie farmaceutică şi metodă de tratament a infecţiilor bacteriene la pacienţi pediatrici

Country Status (33)

Country Link
EP (2) EP1013274A3 (ro)
JP (1) JP3480939B2 (ro)
KR (2) KR19990008253A (ro)
CN (1) CN1104240C (ro)
AP (1) AP851A (ro)
AR (1) AR002993A1 (ro)
AT (2) ATE206051T1 (ro)
AU (1) AU712269C (ro)
BG (2) BG64270B1 (ro)
BR (1) BR9608270A (ro)
CZ (1) CZ294434B6 (ro)
DE (1) DE69615551T2 (ro)
DK (1) DK0825860T3 (ro)
DZ (1) DZ2028A1 (ro)
EA (1) EA001878B1 (ro)
ES (1) ES2160821T3 (ro)
GR (1) GR3036722T3 (ro)
HK (1) HK1009101A1 (ro)
HU (2) HU0201920D0 (ro)
IL (1) IL118091A (ro)
MA (1) MA24339A1 (ro)
MY (1) MY127622A (ro)
NO (1) NO975037D0 (ro)
NZ (1) NZ308478A (ro)
OA (1) OA10533A (ro)
PE (1) PE20011100A1 (ro)
PL (1) PL323103A1 (ro)
PT (1) PT825860E (ro)
RO (1) RO116343B1 (ro)
SK (1) SK283794B6 (ro)
TR (1) TR199701294T1 (ro)
UA (1) UA46763C2 (ro)
WO (1) WO1996034605A1 (ro)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ318282A (en) 1995-09-07 2000-01-28 Smithkline Beecham Corp Pharmaceutical formulation containing amoxycillin and clavulanate in a weight ratio of 12:1 and 20:1
GB9617780D0 (en) * 1996-08-24 1996-10-02 Smithkline Beecham Plc Method of treatment
GB9815532D0 (en) 1998-07-17 1998-09-16 Lek Pharmaceutical & Cvhemical Pharmaceutical suspension formulation
US6177421B1 (en) 1999-05-04 2001-01-23 Fuisz International Ltd. Amoxicillin and clavulanate composition
IE990159A1 (en) * 1999-02-26 2000-09-20 Fuisz Internat Ltd Storage Stable Amoxycillin and Clavulanate Suspension Composition.
US7250176B1 (en) 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
US6294199B1 (en) 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
US6156294A (en) * 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
EP1330236A2 (en) 2000-10-12 2003-07-30 Beecham Pharmaceuticals (Pte) Limited Formulation containing amoxicillin
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
CN100391456C (zh) * 2005-04-30 2008-06-04 南京师范大学 β-环糊精/阿莫西林包合物及其与克拉维酸钾的组合物及制备方法
DE102006007830A1 (de) * 2006-02-17 2007-08-30 Grünenthal GmbH Lagerstabile orale Darreichungsform von Amoxicillin und Clavulansäure
CN101406450B (zh) * 2007-10-12 2010-08-25 河南农业大学 复方阿莫西林油混悬注射液制备工艺
WO2013106601A1 (en) * 2012-01-10 2013-07-18 Michael Spector Pediatric oral suspension formulations of amoxicillin and clavulanate potassium and method for using same
WO2013173808A2 (en) * 2012-05-17 2013-11-21 Michael Spector Methods for use of lower dose compositions of amoxicillin and clavulanate potassium and devices for use
WO2013173803A2 (en) * 2012-05-17 2013-11-21 Michael Spector Formulations of amoxicillin and clavulanate potassium and methods for using same
CN106474122B (zh) * 2016-09-07 2020-04-14 湘北威尔曼制药股份有限公司 一种阿莫西林克拉维酸钾的药物组合物及其应用
CN108403676B (zh) * 2018-03-20 2020-08-21 中山大学 琥珀酸在提高细菌对抗生素敏感性方面的应用
CN117379378A (zh) * 2023-12-07 2024-01-12 山东金瑞生物科技有限公司 一种兽用复方阿莫西林可溶性粉及其制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
US4337887A (en) 1979-09-18 1982-07-06 Weyerhaeuser Company Reinforced half slotted container
NZ198241A (en) * 1980-09-27 1983-12-16 Beecham Group Ltd Tablet containing amoxycillin and potassium clavulanate
EP0080862B1 (en) * 1981-12-02 1985-09-25 Beecham Group Plc Pharmaceutical formulation comprising beta-lactam antibiotics
GB9007945D0 (en) * 1990-04-07 1990-06-06 Beecham Group Plc Pharmaceutical formulation
GB9408117D0 (en) * 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
GB9416599D0 (en) * 1994-08-17 1994-10-12 Smithkline Beecham Plc Pharmaceutical formulation

Also Published As

Publication number Publication date
KR19990008253A (ko) 1999-01-25
EP0825860B1 (en) 2001-09-26
MY127622A (en) 2006-12-29
ES2160821T3 (es) 2001-11-16
NO975037L (no) 1997-10-31
DE69615551T2 (de) 2002-04-25
BG64270B1 (bg) 2004-08-31
HUP9801064A3 (en) 1998-11-30
PT825860E (pt) 2002-01-30
BG64271B1 (bg) 2004-08-31
IL118091A0 (en) 1996-09-12
UA46763C2 (uk) 2002-06-17
CN1189100A (zh) 1998-07-29
EA001878B1 (ru) 2001-10-22
CZ345997A3 (cs) 1998-03-18
DK0825860T3 (da) 2001-11-19
CZ294434B6 (cs) 2005-01-12
PE20011100A1 (es) 2002-01-06
BR9608270A (pt) 1999-05-04
AP851A (en) 2000-06-15
AP9701122A0 (en) 1997-10-31
BG102024A (en) 1998-07-31
CN1104240C (zh) 2003-04-02
GR3036722T3 (en) 2001-12-31
AU712269C (en) 2002-06-06
OA10533A (en) 2002-04-29
PL323103A1 (en) 1998-03-16
EP0825860A1 (en) 1998-03-04
HUP9801064A2 (hu) 1998-08-28
ATE206051T1 (de) 2001-10-15
IL118091A (en) 2004-07-25
SK283794B6 (sk) 2004-01-08
JP3480939B2 (ja) 2003-12-22
AR002993A1 (es) 1998-05-27
EP1013274A3 (en) 2000-07-05
AT4423U1 (de) 2001-07-25
AU5814096A (en) 1996-11-21
NZ308478A (en) 1999-04-29
JPH11504911A (ja) 1999-05-11
TR199701294T1 (xx) 1998-04-21
EP1013274A2 (en) 2000-06-28
BG106763A (en) 2004-05-31
EA199700354A1 (ru) 1998-04-30
SK146297A3 (en) 1998-05-06
HK1009101A1 (en) 1999-05-28
KR20050084498A (ko) 2005-08-26
DE69615551D1 (de) 2001-10-31
AU712269B2 (en) 1999-11-04
NO975037D0 (no) 1997-10-31
MA24339A1 (fr) 1998-07-01
DZ2028A1 (fr) 2002-10-23
WO1996034605A1 (en) 1996-11-07
HU0201920D0 (ro) 2002-08-28

Similar Documents

Publication Publication Date Title
RO116343B1 (ro) Compoziţie farmaceutică şi metodă de tratament a infecţiilor bacteriene la pacienţi pediatrici
EP1243267A3 (en) Amoxycillin and clavulanate containing pharmaceutical formulation
IL119627A0 (en) Controlled-release pharmaceutical preparations
US6726908B2 (en) Pharmaceutical formulation
CA2114014A1 (en) Advanced Drug Delivery System and Method of Treating Psychiatric, Neurological and Other Disorders with Carbamazepine
BR9711642A (pt) Uso de uma combinação de amoxicilina e clavulanato na fabricação de medicamento para o tratamento de streptococcus pneumonia resistente a drogas
EP0680322B1 (en) Use of clavulanate and an antibacterial compound for the treatment of infections
RU95101385A (ru) Продукты, содержащие g-csf и tnf связующие протеина
PL339774A1 (en) Method of preventing nephrotoxicity caused by cephalosporins and tacrolimus
NZ315632A (en) Process for preparing solid dosage forms of very low-dose drugs comprising admixing 1-3% by weight of carrier particles with a solution of drug in water
CA2081348C (en) Veterinary formulation of amoxycillin and clavulanic acid, and derivatives thereof
US5643902A (en) Veterinary treatment
US4663345A (en) Etodolac for treatment of gout
AP9901724A0 (en) Process for the preparation of astable fixed dose pharmaceutical composition of anti-infective agent/ agents and microorganisms as active ingredients.
GB2323532B (en) Process for the preparation of a stable fixed dose pharmaceutical composition of anti-infective agent(s) and micro organisms as active ingredients
CO4700464A1 (es) Metodo de tratamiento
JP3032904B2 (ja) 獣医用治療方法
MX9708383A (es) Composicion que comprende amoxicilina y acido clavulanico.
KR880008807A (ko) 정신병의 치료방법
JPH0243726B2 (ro)
RU95103741A (ru) Лекарственное средство "квинтасоль" для нормализации нарушений кислотно-щелочного равновесия и водно-электролитного баланса
CA2220103A1 (en) Composition comprising amoxycillin and clavulanic acid
MX9605055A (es) Tableta revestida de polimero que comprende amoxicilina y clavulanato.
MX9603766A (es) Metodos de administracion de benzamidas n-substituidas o fenotiazinas.
TH26552A (th) วิธีการรักษา