EA199800179A1 - Способ изготовления твердых лекарственных форм, содежащих лекарства в очень малых дозах - Google Patents

Способ изготовления твердых лекарственных форм, содежащих лекарства в очень малых дозах

Info

Publication number
EA199800179A1
EA199800179A1 EA199800179A EA199800179A EA199800179A1 EA 199800179 A1 EA199800179 A1 EA 199800179A1 EA 199800179 A EA199800179 A EA 199800179A EA 199800179 A EA199800179 A EA 199800179A EA 199800179 A1 EA199800179 A1 EA 199800179A1
Authority
EA
Eurasian Patent Office
Prior art keywords
low
dosage forms
solid dosage
preparing solid
dose drugs
Prior art date
Application number
EA199800179A
Other languages
English (en)
Other versions
EA000740B1 (ru
Inventor
Джеймс Альберт Нэппер
Нил Мортимер
Карен Триона О'Браен
Султан Джеймс Манек
Раджиндер Кумар
Майкл Сидней Джордж Кларк
Джулия Мэри Лоудон
Original Assignee
Смитклайн Бичам Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515624.6A external-priority patent/GB9515624D0/en
Priority claimed from GBGB9606684.0A external-priority patent/GB9606684D0/en
Application filed by Смитклайн Бичам Плс filed Critical Смитклайн Бичам Плс
Publication of EA199800179A1 publication Critical patent/EA199800179A1/ru
Publication of EA000740B1 publication Critical patent/EA000740B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Abstract

Способ изготовления лекарственного средства, который включает смешивание частиц носителя с водным раствором лекарственного вещества в количестве 1-3% раствора от общего веса смеси, и способ лечения и/или профилактики деменции, который включает введение пациенту [R-(Z)]-α-(метоксиимино)-α-(1-азабицикло[2,2,2]окт-3-ил)ацетонитрила моногидрохлорида в суточной дозе менее 0,01 мг/кг, а также фармацевтические композиции, используемые в этих способах.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800179A 1995-07-29 1996-07-29 Способ получения твердого терапевтически активного лекарственного средства, содержащего лекарство в малых дозах, и лекарственное средство, полученное этим способом EA000740B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9515624.6A GB9515624D0 (en) 1995-07-29 1995-07-29 Novel process
GBGB9606684.0A GB9606684D0 (en) 1996-03-29 1996-03-29 Novel process
PCT/EP1996/003326 WO1997004750A2 (en) 1995-07-29 1996-07-29 Process for preparing solid dosage forms of very low-dose drugs

Publications (2)

Publication Number Publication Date
EA199800179A1 true EA199800179A1 (ru) 1998-10-29
EA000740B1 EA000740B1 (ru) 2000-02-28

Family

ID=26307485

Family Applications (2)

Application Number Title Priority Date Filing Date
EA199901055A EA199901055A1 (ru) 1995-07-29 1996-07-29 Фармацевтическая композиция для лечения и/или профилактики деменции
EA199800179A EA000740B1 (ru) 1995-07-29 1996-07-29 Способ получения твердого терапевтически активного лекарственного средства, содержащего лекарство в малых дозах, и лекарственное средство, полученное этим способом

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA199901055A EA199901055A1 (ru) 1995-07-29 1996-07-29 Фармацевтическая композиция для лечения и/или профилактики деменции

Country Status (25)

Country Link
EP (1) EP0841902A2 (ru)
JP (1) JPH11510493A (ru)
KR (1) KR19990035972A (ru)
CN (1) CN1196677A (ru)
AP (1) AP858A (ru)
AR (1) AR004178A1 (ru)
AU (1) AU716961B2 (ru)
BG (1) BG102266A (ru)
BR (1) BR9609804A (ru)
CA (1) CA2228048A1 (ru)
CZ (1) CZ24798A3 (ru)
DZ (1) DZ2077A1 (ru)
EA (2) EA199901055A1 (ru)
HU (1) HUP9900521A3 (ru)
IL (1) IL122897A0 (ru)
MA (1) MA23953A1 (ru)
MX (1) MX9800809A (ru)
NO (1) NO980384L (ru)
NZ (1) NZ315632A (ru)
OA (1) OA10659A (ru)
PL (1) PL325242A1 (ru)
SK (1) SK11098A3 (ru)
TR (1) TR199800156T1 (ru)
UY (1) UY24297A1 (ru)
WO (1) WO1997004750A2 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619074D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Composition
WO1999045924A1 (en) * 1998-03-11 1999-09-16 Smithkline Beecham Plc Composition
FR2796840B1 (fr) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques Comprimes faiblement doses et procede de preparation
CZ306435B6 (cs) 2000-12-14 2017-01-25 Ortho-Mcneil Pharmaceutical, Inc. Steroidní hormonální přípravek a způsob jeho přípravy
US20070202179A1 (en) * 2004-04-09 2007-08-30 FAULKNER Patrick Low Dose Pharmaceutical Products

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489026A (en) * 1982-09-07 1984-12-18 The Upjohn Company Process for preparing solid unit dosage forms of ultra-low dose drugs
JPS5970614A (ja) * 1982-10-14 1984-04-21 Asahi Chem Ind Co Ltd 微量主薬系湿式固形製剤方法
US4898736A (en) * 1988-03-09 1990-02-06 Merck & Co., Inc. Method for tablet preparation
ES2219636T3 (es) * 1989-04-13 2004-12-01 Beecham Group P.L.C. Nuevos compuestos.
ZA939565B (en) * 1993-12-21 1994-08-11 Applied Analytical Ind Inc Method for preparing low dose pharmaceutical products.

Also Published As

Publication number Publication date
EA000740B1 (ru) 2000-02-28
WO1997004750A2 (en) 1997-02-13
BG102266A (en) 1998-10-30
AU716961B2 (en) 2000-03-09
NO980384L (no) 1998-03-26
EA199901055A1 (ru) 2000-06-26
HUP9900521A2 (hu) 1999-06-28
MX9800809A (es) 1998-04-30
AP9801170A0 (en) 1998-01-31
IL122897A0 (en) 1998-08-16
AR004178A1 (es) 1998-11-04
NO980384D0 (no) 1998-01-28
CZ24798A3 (cs) 1998-06-17
WO1997004750A3 (en) 1997-03-27
DZ2077A1 (fr) 2002-07-22
OA10659A (en) 2002-09-18
CA2228048A1 (en) 1997-02-13
NZ315632A (en) 1999-11-29
HUP9900521A3 (en) 2001-04-28
CN1196677A (zh) 1998-10-21
UY24297A1 (es) 1997-01-23
AP858A (en) 2000-07-12
MA23953A1 (fr) 1997-04-01
AU6738496A (en) 1997-02-26
SK11098A3 (en) 1998-07-08
KR19990035972A (ko) 1999-05-25
BR9609804A (pt) 1999-07-06
JPH11510493A (ja) 1999-09-14
PL325242A1 (en) 1998-07-06
TR199800156T1 (xx) 1998-04-21
EP0841902A2 (en) 1998-05-20

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU