WO1993005027A1 - Triazolylated tertiary amine compound or salt thereof - Google Patents

Triazolylated tertiary amine compound or salt thereof Download PDF

Info

Publication number
WO1993005027A1
WO1993005027A1 PCT/JP1992/001089 JP9201089W WO9305027A1 WO 1993005027 A1 WO1993005027 A1 WO 1993005027A1 JP 9201089 W JP9201089 W JP 9201089W WO 9305027 A1 WO9305027 A1 WO 9305027A1
Authority
WO
WIPO (PCT)
Prior art keywords
heterocyclic group
triazolylated
salt
tertiary amine
amine compound
Prior art date
Application number
PCT/JP1992/001089
Other languages
English (en)
French (fr)
Inventor
Minoru Okada
Eiji Kawaminami
Toru Yoden
Masafumi Kudo
Yasuo Isomura
Original Assignee
Yamanouchi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU9400611A priority Critical patent/HU220863B1/hu
Application filed by Yamanouchi Pharmaceutical Co., Ltd. filed Critical Yamanouchi Pharmaceutical Co., Ltd.
Priority to KR1019940700682A priority patent/KR100204697B1/ko
Priority to AU24874/92A priority patent/AU665569B2/en
Priority to UA94005459A priority patent/UA41295C2/uk
Priority to RO94-00319A priority patent/RO114129B1/ro
Priority to US08/199,180 priority patent/US5674886A/en
Priority to EP92918529A priority patent/EP0641785B1/en
Priority to DE69230225T priority patent/DE69230225T2/de
Priority to CA002116773A priority patent/CA2116773C/en
Publication of WO1993005027A1 publication Critical patent/WO1993005027A1/ja
Priority to NO940686A priority patent/NO305284B1/no
Priority to BG98618A priority patent/BG61688B1/bg
Priority to FI940988A priority patent/FI940988A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/JP1992/001089 1991-09-02 1992-08-27 Triazolylated tertiary amine compound or salt thereof WO1993005027A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
US08/199,180 US5674886A (en) 1991-09-02 1992-08-27 Triazolylated teritiary amine compound or salt thereof
KR1019940700682A KR100204697B1 (ko) 1991-09-02 1992-08-27 트리아졸릴 치환된 3급 아민 화합물 또는 이의 염
AU24874/92A AU665569B2 (en) 1991-09-02 1992-08-27 Triazolylated tertiary amine compound or salt thereof
UA94005459A UA41295C2 (uk) 1991-09-02 1992-08-27 Триазолілзаміщені третинні амінні сполуки або їх солі як інгібітор ароматази та фармацевтична композиція на їх основі
RO94-00319A RO114129B1 (ro) 1991-09-02 1992-08-27 Derivaţi aminici terţiari substituiţi cu triazolil
HU9400611A HU220863B1 (en) 1991-09-02 1992-08-27 Triazolylated tertiary amines, process for producing them and pharmaceutical compositions containing them
EP92918529A EP0641785B1 (en) 1991-09-02 1992-08-27 Triazolylated tertiary amine compound or salt thereof
DE69230225T DE69230225T2 (de) 1991-09-02 1992-08-27 Triazolylierte tertiäre aminverbindungen oder ihre salze
CA002116773A CA2116773C (en) 1991-09-02 1992-08-27 Triazolylated tertiary amine compound or salt thereof
NO940686A NO305284B1 (no) 1991-09-02 1994-02-28 Triazolylerte, tertiµre aminoforbindelser eller salter derav og farmas°ytisk preparat inneholdende disse
BG98618A BG61688B1 (bg) 1991-09-02 1994-02-28 Триазолирани третични амини и техни соли
FI940988A FI940988A (fi) 1991-09-02 1994-03-02 Triatsolyloitu tertiäärinen amiiniyhdiste ja sen suola

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP3/248268 1991-09-02
JP24826891 1991-09-02
JP3/344011 1991-12-02
JP34401191 1991-12-02

Publications (1)

Publication Number Publication Date
WO1993005027A1 true WO1993005027A1 (en) 1993-03-18

Family

ID=26538684

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1992/001089 WO1993005027A1 (en) 1991-09-02 1992-08-27 Triazolylated tertiary amine compound or salt thereof

Country Status (20)

Country Link
US (1) US5674886A (ja)
EP (1) EP0641785B1 (ja)
KR (1) KR100204697B1 (ja)
CN (1) CN1035817C (ja)
AT (1) ATE186052T1 (ja)
AU (1) AU665569B2 (ja)
BG (1) BG61688B1 (ja)
CA (1) CA2116773C (ja)
DE (1) DE69230225T2 (ja)
ES (1) ES2139605T3 (ja)
FI (1) FI940988A (ja)
HU (1) HU220863B1 (ja)
MX (1) MX9204996A (ja)
NO (1) NO305284B1 (ja)
PT (1) PT100821B (ja)
RO (1) RO114129B1 (ja)
RU (1) RU2124010C1 (ja)
TW (1) TW225526B (ja)
UA (1) UA41295C2 (ja)
WO (1) WO1993005027A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514374A (ja) * 2001-11-21 2005-05-19 ステリックス リミテッド アロマターゼインヒビターとしてのスルファメート基を含む１，２，４−トリアゾール誘導体
WO2011002096A1 (ja) * 2009-07-03 2011-01-06 独立行政法人理化学研究所 Ｐｅｔ用標識化合物

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770616A (en) 1995-06-07 1998-06-23 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of cancers
US7022702B2 (en) 2000-04-07 2006-04-04 Qlt Inc. Antiproliferative 1,2,3-thiadiazole compounds
US6420400B1 (en) 2000-04-07 2002-07-16 Kinetek Pharmaceuticals, Inc. Antiproliferative 1,2,3-thiadiazole compounds
RU2274639C2 (ru) * 2000-12-22 2006-04-20 Орто-Макнейл Фармасьютикал, Инк. Производные замещенного триазолдиамина, фармацевтическая композиция на их основе и способ ее получения
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
MXPA04004802A (es) * 2001-11-21 2004-08-11 Sterix Ltd Derivados del 1,2,4-triazol que contienen un grupo sulfamato como inhibidores de aromatasa.
EP1431292A1 (en) * 2002-12-16 2004-06-23 Laboratoire Theramex 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
EP1544195A1 (en) * 2003-12-15 2005-06-22 Laboratoire Theramex 1-N-phenyl-amino- 1H-imidazole derivatives and pharmaceutical compositions containing them
AR047144A1 (es) * 2003-12-15 2006-01-11 Theramex Derivados de 1-n-fenilamino-1h-imidazol y composiciones farmaceuticas que los contienen
AU2011226950B9 (en) * 2003-12-15 2013-04-11 Laboratoire Theramex 1-N-phenyl-amino-1H-imidazole derivatives and pharmaceutical compositions containing them
GB0411562D0 (en) 2004-05-24 2004-06-23 Sterix Ltd Compound
GB0914767D0 (en) * 2009-08-24 2009-09-30 Sterix Ltd Compound
CN113387894B (zh) * 2021-06-22 2023-02-24 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) 1-n-苯乙腈基氨基-三氮唑和嘧啶衍生物及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
US4609666A (en) * 1984-06-18 1986-09-02 Eli Lilly And Company Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles
EP0236940A2 (en) 1986-03-07 1987-09-16 Ciba-Geigy Ag Alpha-heterocycle substituted tolunitriles
JPS63145270A (ja) * 1986-12-03 1988-06-17 サンド・アクチエンゲゼルシャフト アゾール誘導体
EP0293978A2 (en) 1987-06-01 1988-12-07 Janssen Pharmaceutica N.V. (1H-azol-1-ylmethyl)substituted benzotriazole derivatives
US5041458A (en) 1987-03-20 1991-08-20 E. I. Du Pont De Nemours And Company Fungicidal aminotriazoles and aminoimidazoles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0283245A1 (en) * 1987-03-20 1988-09-21 E.I. Du Pont De Nemours And Company Fungicidal aminotriazoles and aminoimidazoles
US4806554A (en) * 1988-01-11 1989-02-21 Hoechst-Roussel Pharmaceuticals, Inc. Pyrazol and indazolpyridinamines
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
US4609666A (en) * 1984-06-18 1986-09-02 Eli Lilly And Company Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles
EP0236940A2 (en) 1986-03-07 1987-09-16 Ciba-Geigy Ag Alpha-heterocycle substituted tolunitriles
JPS63145270A (ja) * 1986-12-03 1988-06-17 サンド・アクチエンゲゼルシャフト アゾール誘導体
US5041458A (en) 1987-03-20 1991-08-20 E. I. Du Pont De Nemours And Company Fungicidal aminotriazoles and aminoimidazoles
EP0293978A2 (en) 1987-06-01 1988-12-07 Janssen Pharmaceutica N.V. (1H-azol-1-ylmethyl)substituted benzotriazole derivatives

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BR. J. CANCER, vol. 60, 1989, pages 5
CLINICAL ENDOCRINOLOQY, vol. 32, 1990, pages 623
ENDOCRINOL. JAPAN, vol. 37, no. 5, 1990, pages 719
ENDOCRINOLOQY, vol. 114, no. 2, 1984, pages 486
ENDOCRINOLOQY, vol. 126, no. 6, 1990, pages 3263
J. BIOL. CHEM., vol. 249, 1974, pages 5364
J. STEROID BIOCHEM. MOLEC. BIOL., vol. 37, no. 3, 1990, pages 335
J. STEROID BIOCHEM., vol. 34, 1989, pages 567
J. VET., PHARMACOL. THERAP., vol. 11, 1988, pages 345
STEROIDS, vol. 50, 1987, pages 1
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 244, no. 2, 1988

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514374A (ja) * 2001-11-21 2005-05-19 ステリックス リミテッド アロマターゼインヒビターとしてのスルファメート基を含む１，２，４−トリアゾール誘導体
US7745472B2 (en) 2001-11-21 2010-06-29 Sterix Limited Compound
JP4771660B2 (ja) * 2001-11-21 2011-09-14 ステリックス リミテッド アロマターゼインヒビターとしてのスルファメート基を含む１，２，４−トリアゾール誘導体
WO2011002096A1 (ja) * 2009-07-03 2011-01-06 独立行政法人理化学研究所 Ｐｅｔ用標識化合物
JP5777163B2 (ja) * 2009-07-03 2015-09-09 国立研究開発法人理化学研究所 Ｐｅｔ用標識化合物

Also Published As

Publication number Publication date
ES2139605T3 (es) 2000-02-16
HU220863B1 (en) 2002-06-29
EP0641785B1 (en) 1999-10-27
BG98618A (bg) 1995-03-31
NO940686L (ja) 1994-04-29
HUT67249A (en) 1995-03-28
ATE186052T1 (de) 1999-11-15
US5674886A (en) 1997-10-07
BG61688B1 (bg) 1998-03-31
NO940686D0 (no) 1994-02-28
UA41295C2 (uk) 2001-09-17
EP0641785A4 (en) 1994-06-16
NO305284B1 (no) 1999-05-03
KR100204697B1 (ko) 1999-06-15
DE69230225D1 (de) 1999-12-02
DE69230225T2 (de) 2000-05-31
FI940988A0 (fi) 1994-03-02
PT100821A (pt) 1993-11-30
RU2124010C1 (ru) 1998-12-27
FI940988A (fi) 1994-04-05
EP0641785A1 (en) 1995-03-08
PT100821B (pt) 1999-07-30
AU665569B2 (en) 1996-01-11
RO114129B1 (ro) 1999-01-29
CN1069974A (zh) 1993-03-17
CA2116773A1 (en) 1993-03-18
HU9400611D0 (en) 1994-09-28
CN1035817C (zh) 1997-09-10
MX9204996A (es) 1993-08-01
TW225526B (ja) 1994-06-21
CA2116773C (en) 2002-12-10
AU2487492A (en) 1993-04-05

Similar Documents

Publication Publication Date Title
WO1993005027A1 (en) Triazolylated tertiary amine compound or salt thereof
EP0372484A3 (en) Condensed benzene derivative
RU94016190A (ru) Триазолилзамещенные третичные аминные соединения и их соли, способ их получения и содержащие их ингибитор ароматазы и фармацевтический состав
MY103241A (en) Imidazole and 1,2,4 triazole derivatives
FR2378780A1 (fr) Nouveaux derives heterocycliques de 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles et 1h-1,2,4-triazoles utiles pour lutter contre des champignons et bacteries
ES8707190A1 (es) Procedimiento para la obtencion de -aril-1h-azol-1-etanoles
EP0247760A3 (en) Benzoheterocyclic fungicides
GB1237509A (en) 0-trityl-1,2,4-triazoles
MX9707697A (es) Agente antimicotico de triazol.
JPS643104A (en) Substituted nitroalkene
EP0820989A4 (en) IMIDAZOLE DERIVATIVES AND MEDICINAL COMPOSITION BASED ON SAID DERIVATIVES
DE3070234D1 (en) Process for the preparation of 1h-azole derivatives
EP0680960A4 (en) IMIDAZOLE CONNECTION.
GB1519580A (en) Aminomethylazole derivatives and their use as fungicides and plant-growth rugalators
EP0617961A4 (en) INHIBITOR OF EOSINOPHILIN INFILTRATION.
ES2021476B3 (es) Azolilmetilciclopropano y su aplicacion como medio protector de plantas
FI955555A (fi) N-syaaniditioimino-karbonaattien ja 3-merkapto-S-amino-1H-1,2,4-triatsolin valmistus
AU3673089A (en) (1,3-imidazole, triazole pyrimidine or pyridine) amide N-substituted compounds with antifungal action
NZ306439A (en) 1-(2-(substituted phenyl)-2-hydroxy-ethyl) substituted imidazolyl or 1,2,4-triazolyl derivatives and antimycotic medicaments
IT1085353B (it) Composizione fungicida
JPS5740466A (en) Aminoethyl-substituted pyrazole derivative and its preparation
BA97145B1 (bs) Postupak za dobivanje 2-(2,4 difluorofenil)-1,3-bis-(1H-1,2,4-tiazol-1-il)-propan-2-ola
FR2033065A5 (en) Organo-titanium compounds
NO163817C (no) Mellomprodukter for fremstilling av ((4-(-4-(4-fenyl-1-piperazinyl)fenoksymetyl)-1,3-dioksolan-2-yl)-metyl)-1h-imidazoler og 1h-1,2,4-triazoler.
TH9116EX (th) สารประกอบเฮโลโพรพาร์กิล , สารผสมการใช้ประโยชน์และกรรมวิธีของการผลิตของสารนี้

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU BB BG BR CA CS FI HU JP KR LK MG MN MW NO PL RO RU SD US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL SE BF BJ CF CG CI CM GA GN ML MR SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
EX32 Extension under rule 32 effected after completion of technical preparation for international publication
EX32 Extension under rule 32 effected after completion of technical preparation for international publication
LE32 Later election for international application filed prior to expiration of 19th month from priority date or according to rule 32.2 (b)
LE32 Later election for international application filed prior to expiration of 19th month from priority date or according to rule 32.2 (b)
WWE Wipo information: entry into national phase

Ref document number: 08199180

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2116773

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 940988

Country of ref document: FI

Ref document number: 94-00319

Country of ref document: RO

WWE Wipo information: entry into national phase

Ref document number: 1992918529

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1992918529

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1992918529

Country of ref document: EP