FR2378780A1 - Nouveaux derives heterocycliques de 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles et 1h-1,2,4-triazoles utiles pour lutter contre des champignons et bacteries - Google Patents

Nouveaux derives heterocycliques de 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles et 1h-1,2,4-triazoles utiles pour lutter contre des champignons et bacteries

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Publication number
FR2378780A1
FR2378780A1 FR7802565A FR7802565A FR2378780A1 FR 2378780 A1 FR2378780 A1 FR 2378780A1 FR 7802565 A FR7802565 A FR 7802565A FR 7802565 A FR7802565 A FR 7802565A FR 2378780 A1 FR2378780 A1 FR 2378780A1
Authority
FR
France
Prior art keywords
dioxolan
imidazoles
ylmethyl
bacteria
heterocyclic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7802565A
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English (en)
Other versions
FR2378780B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of FR2378780A1 publication Critical patent/FR2378780A1/fr
Application granted granted Critical
Publication of FR2378780B1 publication Critical patent/FR2378780B1/fr
Granted legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne un composé chimique ayant pour formule :
FR7802565A 1977-01-31 1978-01-30 Nouveaux derives heterocycliques de 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles et 1h-1,2,4-triazoles utiles pour lutter contre des champignons et bacteries Granted FR2378780A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76426577A 1977-01-31 1977-01-31
US05/853,726 US4160841A (en) 1977-01-31 1977-11-21 Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles

Publications (2)

Publication Number Publication Date
FR2378780A1 true FR2378780A1 (fr) 1978-08-25
FR2378780B1 FR2378780B1 (fr) 1984-11-30

Family

ID=27117425

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7802565A Granted FR2378780A1 (fr) 1977-01-31 1978-01-30 Nouveaux derives heterocycliques de 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles et 1h-1,2,4-triazoles utiles pour lutter contre des champignons et bacteries

Country Status (24)

Country Link
US (1) US4160841A (fr)
JP (1) JPS53101377A (fr)
AT (1) AT367419B (fr)
AU (1) AU511358B2 (fr)
BE (1) BE863437A (fr)
CA (1) CA1117534A (fr)
CH (1) CH644117A5 (fr)
DE (1) DE2803870A1 (fr)
DK (1) DK42778A (fr)
ES (1) ES466483A1 (fr)
FI (1) FI62836C (fr)
FR (1) FR2378780A1 (fr)
GB (1) GB1594860A (fr)
GR (1) GR66115B (fr)
HU (1) HU177458B (fr)
IE (1) IE46055B1 (fr)
IL (1) IL53924A (fr)
IT (1) IT1105153B (fr)
LU (1) LU78969A1 (fr)
NL (1) NL7801088A (fr)
PH (1) PH13955A (fr)
PT (1) PT67599B (fr)
SE (1) SE439633B (fr)
SU (1) SU703020A3 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2438046A1 (fr) * 1978-10-06 1980-04-30 Janssen Pharmaceutica Nv Nouveaux derives antimicrobiens de triazole, procede de preparation et composition pour combattre les champignons en contenant

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
EP0006722B1 (fr) * 1978-07-03 1984-09-05 Janssen Pharmaceutica N.V. Dérivés de (4-(pipérazin-1-yl-phényloxyméthyl)-1.3-dioxolan-2-ylméthyl)-1H-imidazoles et -1H-1.2.4-triazoles, leur préparation et leur utilisation comme fongicides et bactéricides
US4287195A (en) * 1978-07-14 1981-09-01 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles
US4402957A (en) * 1979-04-04 1983-09-06 Janssen Pharmaceutica N.V. Heterocyclic derivatives of [4-(piperazin-1-ylphenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles
DE3039087A1 (de) * 1980-10-16 1982-05-19 Hoechst Ag, 6000 Frankfurt 1-(1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung
DE3104311A1 (de) * 1981-02-07 1982-08-19 Bayer Ag, 5090 Leverkusen 2-azolylmethyl-1,3-dioxolan- und -dioxan-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
DE3104380A1 (de) * 1981-02-07 1982-08-19 Bayer Ag, 5090 Leverkusen Antimikrobielle mittel
US4456605A (en) * 1981-05-07 1984-06-26 Janssen Pharmaceutica N.V. Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles
JPS59139380A (ja) * 1983-01-28 1984-08-10 Yoshiki Hamada １，３―ジオキソランアシラート誘導体及びその製造法
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
DE3484023D1 (de) * 1983-03-03 1991-03-07 Basf Ag Azolylmethylcycloalkane, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
DE3308554A1 (de) * 1983-03-10 1984-09-13 Hoechst Ag, 6230 Frankfurt 1-/1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung
JPS59205366A (ja) * 1983-04-12 1984-11-20 スミスクライン・ベツクマン・コ−ポレイシヨン ド−パミン−β−ヒドロキシラ−ゼ抑制物質
JP2004511548A (ja) 2000-10-16 2004-04-15 中外製薬株式会社 Ｎ−置換された２−スルファニルイミダゾールの調製方法
US20050074494A1 (en) * 2003-10-06 2005-04-07 Xiu-Xiu Cheng Itraconazole immediate release formulation
WO2007021877A1 (fr) 2005-08-18 2007-02-22 Synta Pharmaceuticals Corp. Dérivés d'imidazole modulant l'activité de hsp90
KR100793693B1 (ko) 2006-05-09 2008-01-10 (주)유케이케미팜 이트라코나졸의 개선된 제조 방법
NZ709362A (en) * 2012-12-25 2019-07-26 Hua Medicine Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1h-pyrazol-3-ylamine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3936470A (en) * 1975-01-27 1976-02-03 Janssen Pharmaceutica N.V. 1,3-Dioxolan-2-ylmethylimidazoles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3575999A (en) * 1968-08-19 1971-04-20 Janssen Pharmaceutica Nv Ketal derivatives of imidazole
CA1065873A (fr) * 1975-01-27 1979-11-06 Janssen Pharmaceutica Naamloze Vennootschap Derives de l'imidazole
US4101666A (en) * 1975-10-06 1978-07-18 Janssen Pharmaceutica N.V. 1-(2-Ar-4-R-1,3-dioxolan-2-ylmethyl)imidazoles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3936470A (en) * 1975-01-27 1976-02-03 Janssen Pharmaceutica N.V. 1,3-Dioxolan-2-ylmethylimidazoles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2438046A1 (fr) * 1978-10-06 1980-04-30 Janssen Pharmaceutica Nv Nouveaux derives antimicrobiens de triazole, procede de preparation et composition pour combattre les champignons en contenant

Also Published As

Publication number Publication date
US4160841A (en) 1979-07-10
DE2803870A1 (de) 1978-08-03
HU177458B (en) 1981-10-28
GB1594860A (en) 1981-08-05
PT67599B (en) 1980-01-14
JPS53101377A (en) 1978-09-04
IE780196L (en) 1978-07-31
IT1105153B (it) 1985-10-28
CA1117534A (fr) 1982-02-02
FI62836B (fi) 1982-11-30
FI780293A (fi) 1978-08-01
AT367419B (de) 1982-07-12
SE439633B (sv) 1985-06-24
ATA63778A (de) 1981-11-15
AU3285278A (en) 1979-08-09
LU78969A1 (fr) 1978-06-21
IL53924A0 (en) 1978-04-30
SU703020A3 (ru) 1979-12-05
JPS6339595B2 (fr) 1988-08-05
NL7801088A (nl) 1978-08-02
IL53924A (en) 1981-12-31
SE7801089L (sv) 1978-08-01
PH13955A (en) 1980-11-12
ES466483A1 (es) 1979-06-01
AU511358B2 (en) 1980-08-14
IE46055B1 (en) 1983-02-09
GR66115B (fr) 1981-01-16
BE863437A (nl) 1978-07-31
FI62836C (fi) 1983-03-10
PT67599A (en) 1978-02-01
CH644117A5 (de) 1984-07-13
FR2378780B1 (fr) 1984-11-30
IT7847838A0 (it) 1978-01-30
DK42778A (da) 1978-08-01

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