WO1991009118A3 - Proteines fibrinolytiques et antithrombotiques activables - Google Patents

Proteines fibrinolytiques et antithrombotiques activables Download PDF

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Publication number
WO1991009118A3
WO1991009118A3 PCT/GB1990/001912 GB9001912W WO9109118A3 WO 1991009118 A3 WO1991009118 A3 WO 1991009118A3 GB 9001912 W GB9001912 W GB 9001912W WO 9109118 A3 WO9109118 A3 WO 9109118A3
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WO
WIPO (PCT)
Prior art keywords
pct
fibrinolytic
activatable
clot formation
date jun
Prior art date
Application number
PCT/GB1990/001912
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English (en)
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WO1991009118A2 (fr
Inventor
Keith Martyn Dawson
Richard Mark Edwards
Joan Mabel Forman
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British Bio Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology filed Critical British Bio Technology
Priority to DE69031127T priority Critical patent/DE69031127T2/de
Priority to KR1019920701348A priority patent/KR100188302B1/ko
Priority to EP91900851A priority patent/EP0502968B1/fr
Priority to US07/854,603 priority patent/US5637492A/en
Publication of WO1991009118A2 publication Critical patent/WO1991009118A2/fr
Publication of WO1991009118A3 publication Critical patent/WO1991009118A3/fr
Priority to NO922238A priority patent/NO305562B1/no
Priority to FI922610A priority patent/FI105202B/fi
Priority to US08/147,000 priority patent/US5688664A/en
Priority to GR970402633T priority patent/GR3024990T3/el

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    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
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    • C07K14/81—Protease inhibitors
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
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    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
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    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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Abstract

Des composés protéiniques peuvent être activés par des enzymes de la cascade de coagulation de manière à exercer une activité fibrinolytique ou inhibitrice de coagulation. Par exemple, un analogue de plasminogène peut être activé pour former de la plasmine au moyen de la thrombine ou le facteur Xa. L'activité fibrinolytique ou inhibitrice de coagulation est donc dirigée au site de coagulation.
PCT/GB1990/001912 1989-12-07 1990-12-07 Proteines fibrinolytiques et antithrombotiques activables WO1991009118A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE69031127T DE69031127T2 (de) 1989-12-07 1990-12-07 Aktivierbare fibrinolytische und antithrombotische proteine
KR1019920701348A KR100188302B1 (ko) 1989-12-07 1990-12-07 활성화피브린용해성과항-혈전성단백질
EP91900851A EP0502968B1 (fr) 1989-12-07 1990-12-07 Proteines fibrinolytiques et antithrombotiques activables
US07/854,603 US5637492A (en) 1989-12-07 1990-12-07 Activatable fibrinolytic and anti-thrombotic proteins
NO922238A NO305562B1 (no) 1989-12-07 1992-06-05 FremgangsmÕte for fremstilling av en plasminogenanalog, syntetisk eller rekombinant nukleinsyre som koder for den, vektorer som omfatter en slik nukleinsyresekvens, samt celler eller cellelinjer som kan fremstille plasminogenanalogen
FI922610A FI105202B (fi) 1989-12-07 1992-06-05 Menetelmä aktivoitavien fibrinolyyttisten ja veren hyytymistä estävien plasminogeenianalogien valmistamiseksi
US08/147,000 US5688664A (en) 1990-12-07 1993-10-29 Thrombin activatable plasminogen analogues
GR970402633T GR3024990T3 (en) 1989-12-07 1997-10-09 Activatable fibrinolytic and anti-thrombotic proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898927722A GB8927722D0 (en) 1989-12-07 1989-12-07 Proteins and nucleic acids
GB8927722.2 1989-12-07

Publications (2)

Publication Number Publication Date
WO1991009118A2 WO1991009118A2 (fr) 1991-06-27
WO1991009118A3 true WO1991009118A3 (fr) 1991-10-31

Family

ID=10667597

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/GB1990/001911 WO1991009125A1 (fr) 1989-12-07 1990-12-07 Proteines et acides nucleiques
PCT/GB1990/001912 WO1991009118A2 (fr) 1989-12-07 1990-12-07 Proteines fibrinolytiques et antithrombotiques activables

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/GB1990/001911 WO1991009125A1 (fr) 1989-12-07 1990-12-07 Proteines et acides nucleiques

Country Status (21)

Country Link
US (2) US5434073A (fr)
EP (2) EP0502968B1 (fr)
JP (2) JP2851423B2 (fr)
KR (2) KR920703818A (fr)
AT (1) ATE155812T1 (fr)
AU (3) AU644399B2 (fr)
CA (2) CA2069085C (fr)
DE (1) DE69031127T2 (fr)
DK (1) DK0502968T3 (fr)
ES (1) ES2106073T3 (fr)
FI (2) FI922609A (fr)
GB (1) GB8927722D0 (fr)
GR (1) GR3024990T3 (fr)
HU (1) HU211628A9 (fr)
IE (2) IE81046B1 (fr)
IL (2) IL96601A (fr)
NO (2) NO305562B1 (fr)
NZ (2) NZ236330A (fr)
PT (2) PT96103B (fr)
WO (2) WO1991009125A1 (fr)
ZA (2) ZA909854B (fr)

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GB9222758D0 (en) * 1992-10-29 1992-12-09 British Bio Technology Proteins and nucleic acids
GB9216558D0 (en) * 1992-08-04 1992-09-16 British Bio Technology Modified proteases
GB2286190B (en) * 1992-10-29 1996-05-01 British Biotech Pharm Thrombin activatable plasminogen derivatives
DE4323754C1 (de) * 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
JPH08502661A (ja) * 1993-08-04 1996-03-26 チバ−ガイギー アクチェンゲゼルシャフト 高分子量デスルファトヒルジン
ES2080657B1 (es) * 1993-09-27 1996-11-01 Britisch Bio Technology Limite Proteasas modificadas.
US5837682A (en) 1996-03-08 1998-11-17 The Children's Medical Center Corporation Angiostatin fragments and method of use
CN1309833C (zh) * 1994-04-26 2007-04-11 儿童医学中心公司 血管生成抑制素及其在制备药物中的用途
US5945403A (en) 1997-05-30 1999-08-31 The Children's Medical Center Corporation Angiostatin fragments and method of use
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
DE4442665A1 (de) * 1994-11-30 1996-06-05 Gruenenthal Gmbh Chimäre Proteine mit fibrinolytischen und thrombinhemmenden Eigenschaften
US5854049A (en) * 1995-06-09 1998-12-29 President And Fellows Of Harvard College Plasmin-resistant streptokinase
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
US6461640B1 (en) 1995-12-08 2002-10-08 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
KR20000029755A (ko) * 1996-08-02 2000-05-25 로셰 디아그노스틱스 게엠베하 트롬빈에의해활성화될수있는플라스미노겐활성화제
DE69833755T2 (de) * 1997-05-21 2006-12-28 Biovation Ltd. Verfahren zur herstellung von nicht-immunogenen proteinen
ATE203567T1 (de) * 1998-03-19 2001-08-15 Instrumentation Lab Spa Verbesserte in vitro verfahren, testkits und reagenzien zum screening von blutgerinnungsfehlern
AU5571799A (en) 1998-08-20 2000-03-14 University Of Vermont And State Agricultural College, The Angiogenesis inhibitors and uses thereof
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US6423826B1 (en) * 2000-06-30 2002-07-23 Regents Of The University Of Minnesota High molecular weight derivatives of vitamin K-dependent polypeptides
US7160540B2 (en) 2000-06-30 2007-01-09 Regents Of The University Of Minnesota Methods for detecting activity of clottings factors
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
AU8591901A (en) * 2000-09-05 2002-03-22 Karolinska Innovations Ab Materials and methods relating to endothelial cell growth inhibitors
DE10108212A1 (de) * 2001-02-20 2002-08-22 Aventis Pharma Gmbh Fusionsprotein zur Sekretion von Wertprotein in bakterielle Überstände
DE10108100A1 (de) * 2001-02-20 2002-08-29 Aventis Pharma Gmbh Verwendung supersekretierbarer Peptide in Verfahren zu deren Herstellung und paralleler Verbesserung der Exportate eines oder mehrerer anderer Polypeptide von Interesse
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