GB2286190B - Thrombin activatable plasminogen derivatives - Google Patents

Thrombin activatable plasminogen derivatives

Info

Publication number
GB2286190B
GB2286190B GB9508106A GB9508106A GB2286190B GB 2286190 B GB2286190 B GB 2286190B GB 9508106 A GB9508106 A GB 9508106A GB 9508106 A GB9508106 A GB 9508106A GB 2286190 B GB2286190 B GB 2286190B
Authority
GB
United Kingdom
Prior art keywords
thrombin activatable
activatable plasminogen
plasminogen derivatives
derivatives
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9508106A
Other versions
GB2286190A (en
GB9508106D0 (en
Inventor
Richard James Gilbert
Michael George Hunter
Keith Martyn Dawson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929222758A external-priority patent/GB9222758D0/en
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Priority to GB9508106A priority Critical patent/GB2286190B/en
Publication of GB9508106D0 publication Critical patent/GB9508106D0/en
Publication of GB2286190A publication Critical patent/GB2286190A/en
Application granted granted Critical
Publication of GB2286190B publication Critical patent/GB2286190B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
GB9508106A 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives Expired - Fee Related GB2286190B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9508106A GB2286190B (en) 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929222758A GB9222758D0 (en) 1992-10-29 1992-10-29 Proteins and nucleic acids
GB9508106A GB2286190B (en) 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives
PCT/GB1993/002219 WO1994010318A1 (en) 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives

Publications (3)

Publication Number Publication Date
GB9508106D0 GB9508106D0 (en) 1995-06-14
GB2286190A GB2286190A (en) 1995-08-09
GB2286190B true GB2286190B (en) 1996-05-01

Family

ID=26301882

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9508106A Expired - Fee Related GB2286190B (en) 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives

Country Status (1)

Country Link
GB (1) GB2286190B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009118A2 (en) * 1989-12-07 1991-06-27 British Bio-Technology Limited Activatable fibrinolytic and anti-thrombotic proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009118A2 (en) * 1989-12-07 1991-06-27 British Bio-Technology Limited Activatable fibrinolytic and anti-thrombotic proteins

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Agric.Biol.Chem. 1988,52(2),329-336 *
Biochemistry 1986,25,2417-2424 *
J.Biol.Chem. 1986,261(8),3486-3489 *
J.Biol.Chem. 1991,266(12),7353-7358 *
Nature 1989,339,721-723 *
Science 1991,253,909-912 *
Thromb.Haemostatis 1990,64(3),426-432 *

Also Published As

Publication number Publication date
GB2286190A (en) 1995-08-09
GB9508106D0 (en) 1995-06-14

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20101028