GB9216558D0 - Modified proteases - Google Patents

Modified proteases

Info

Publication number
GB9216558D0
GB9216558D0 GB929216558A GB9216558A GB9216558D0 GB 9216558 D0 GB9216558 D0 GB 9216558D0 GB 929216558 A GB929216558 A GB 929216558A GB 9216558 A GB9216558 A GB 9216558A GB 9216558 D0 GB9216558 D0 GB 9216558D0
Authority
GB
United Kingdom
Prior art keywords
pct
modified
date feb
proteases
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB929216558A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Bio Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Bio Technology Ltd filed Critical British Bio Technology Ltd
Priority to GB929216558A priority Critical patent/GB9216558D0/en
Publication of GB9216558D0 publication Critical patent/GB9216558D0/en
Priority to EP93917972A priority patent/EP0658206B1/en
Priority to JP50511494A priority patent/JP3449717B2/en
Priority to PCT/GB1993/001632 priority patent/WO1994003614A1/en
Priority to US08/379,621 priority patent/US5645833A/en
Priority to AT93917972T priority patent/ATE282089T1/en
Priority to ES93917972T priority patent/ES2232812T3/en
Priority to DE69333689T priority patent/DE69333689T2/en
Priority to AU47200/93A priority patent/AU4720093A/en
Priority to ZA935660A priority patent/ZA935660B/en
Priority to US08/889,078 priority patent/US5932213A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PCT No. PCT/GB93/01632 Sec. 371 Date Feb. 3, 1995 Sec. 102(e) Date Feb. 3, 1995 PCT Filed Aug. 3, 1993 PCT Pub. No. WO94/03614 PCT Pub. Date Feb. 17, 1994Serine proteases of the chymotrypsin superfamily are modified so that they exhibit resistance to serine protease inhibitors. If such modified serine proteases have fibrinolytic, thrombolytic, antithrombotic or prothrombotic properties, they are useful in the treatment of blood clotting diseases or conditions.
GB929216558A 1992-08-04 1992-08-04 Modified proteases Pending GB9216558D0 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB929216558A GB9216558D0 (en) 1992-08-04 1992-08-04 Modified proteases
AU47200/93A AU4720093A (en) 1992-08-04 1993-08-03 Inhibitor resistant serine proteases
US08/379,621 US5645833A (en) 1992-08-04 1993-08-03 Inhibitor resistant serine proteases
JP50511494A JP3449717B2 (en) 1992-08-04 1993-08-03 Inhibitor resistant serine protease
PCT/GB1993/001632 WO1994003614A1 (en) 1992-08-04 1993-08-03 Inhibitor resistant serine proteases
EP93917972A EP0658206B1 (en) 1992-08-04 1993-08-03 Inhibitor resistant serine proteases
AT93917972T ATE282089T1 (en) 1992-08-04 1993-08-03 INHIBITOR-RESISTANT SERINE PROTEASES
ES93917972T ES2232812T3 (en) 1992-08-04 1993-08-03 SERINA PROTEASAS RESISTANT TO INHIBITORS.
DE69333689T DE69333689T2 (en) 1992-08-04 1993-08-03 INHIBITOR RESISTANT SERIN PROTEASES
ZA935660A ZA935660B (en) 1992-08-04 1993-08-14 Modified proteases.
US08/889,078 US5932213A (en) 1992-08-04 1997-07-07 Modified plasmin precursors with resistance to inhibitors of plasmin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929216558A GB9216558D0 (en) 1992-08-04 1992-08-04 Modified proteases

Publications (1)

Publication Number Publication Date
GB9216558D0 true GB9216558D0 (en) 1992-09-16

Family

ID=10719807

Family Applications (1)

Application Number Title Priority Date Filing Date
GB929216558A Pending GB9216558D0 (en) 1992-08-04 1992-08-04 Modified proteases

Country Status (10)

Country Link
US (2) US5645833A (en)
EP (1) EP0658206B1 (en)
JP (1) JP3449717B2 (en)
AT (1) ATE282089T1 (en)
AU (1) AU4720093A (en)
DE (1) DE69333689T2 (en)
ES (1) ES2232812T3 (en)
GB (1) GB9216558D0 (en)
WO (1) WO1994003614A1 (en)
ZA (1) ZA935660B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033471A1 (en) * 1994-06-07 1995-12-14 Hellgren, Lars Intravasal thrombolysis
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
US6942978B1 (en) * 1999-03-03 2005-09-13 The Board Of Trustees Of The University Of Arkansas Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
US7700341B2 (en) 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
JP2001275677A (en) * 2000-03-30 2001-10-09 Canon Inc Nucleic acid fragment primer or probe, and method for detecting, using the same, microorganism capable of synthesizing polyhydroxyalkanoate
JP2005508141A (en) 2001-05-25 2005-03-31 セローノ ジェネティクス インスティテュート ソシエテ アニニム Human cDNAs and proteins and their use
DE102006053404A1 (en) * 2006-11-10 2008-05-15 Hydro Aluminium Alucast Gmbh Casting mold for casting a casting and use of such a casting mold
US20180340163A1 (en) * 2015-11-25 2018-11-29 Academisch Ziekenhuis Leiden Recombinant serine proteases
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use
KR20210110848A (en) 2018-12-28 2021-09-09 카탈리스트 바이오사이언시즈, 인코포레이티드 Modified urokinase type plasminogen activator polypeptides and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2007364A1 (en) * 1989-01-17 1990-07-17 David J. Livingston Gene sequences encoding modified residues situated in the protease domain of tpa
US5304482A (en) * 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
DE69034013T2 (en) * 1989-03-06 2003-07-31 Univ Texas Serpin-resistant T-PA; mutants; Gene
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
JPH07509610A (en) 1995-10-26
WO1994003614A1 (en) 1994-02-17
EP0658206B1 (en) 2004-11-10
US5645833A (en) 1997-07-08
DE69333689T2 (en) 2005-11-03
AU4720093A (en) 1994-03-03
EP0658206A1 (en) 1995-06-21
US5932213A (en) 1999-08-03
JP3449717B2 (en) 2003-09-22
ZA935660B (en) 1994-03-17
DE69333689D1 (en) 2004-12-16
ES2232812T3 (en) 2005-06-01
ATE282089T1 (en) 2004-11-15

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