ATE203567T1 - Verbesserte in vitro verfahren, testkits und reagenzien zum screening von blutgerinnungsfehlern - Google Patents

Verbesserte in vitro verfahren, testkits und reagenzien zum screening von blutgerinnungsfehlern

Info

Publication number
ATE203567T1
ATE203567T1 AT98105043T AT98105043T ATE203567T1 AT E203567 T1 ATE203567 T1 AT E203567T1 AT 98105043 T AT98105043 T AT 98105043T AT 98105043 T AT98105043 T AT 98105043T AT E203567 T1 ATE203567 T1 AT E203567T1
Authority
AT
Austria
Prior art keywords
reagents
coagulation
conversion rate
improved
blood clotting
Prior art date
Application number
AT98105043T
Other languages
English (en)
Inventor
Bert Steffen Rosen
Christina Maria Yvonne Hall
Original Assignee
Instrumentation Lab Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instrumentation Lab Spa filed Critical Instrumentation Lab Spa
Application granted granted Critical
Publication of ATE203567T1 publication Critical patent/ATE203567T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT98105043T 1998-03-19 1998-03-19 Verbesserte in vitro verfahren, testkits und reagenzien zum screening von blutgerinnungsfehlern ATE203567T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98105043A EP0947585B1 (de) 1998-03-19 1998-03-19 Verbesserte in vitro Verfahren, Testkits und Reagenzien zum Screening von Blutgerinnungsfehlern

Publications (1)

Publication Number Publication Date
ATE203567T1 true ATE203567T1 (de) 2001-08-15

Family

ID=8231624

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98105043T ATE203567T1 (de) 1998-03-19 1998-03-19 Verbesserte in vitro verfahren, testkits und reagenzien zum screening von blutgerinnungsfehlern

Country Status (12)

Country Link
US (4) US6395501B1 (de)
EP (1) EP0947585B1 (de)
AT (1) ATE203567T1 (de)
AU (2) AU758831B2 (de)
CA (1) CA2334935C (de)
DE (1) DE69801210T2 (de)
DK (1) DK0947585T3 (de)
ES (1) ES2162361T3 (de)
GR (1) GR3036865T3 (de)
NZ (1) NZ506747A (de)
PT (1) PT947585E (de)
WO (1) WO1999047699A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6898532B1 (en) 1995-06-07 2005-05-24 Biomerieux, Inc. Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample
US6321164B1 (en) 1995-06-07 2001-11-20 Akzo Nobel N.V. Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade
US6429017B1 (en) * 1999-02-04 2002-08-06 Biomerieux Method for predicting the presence of haemostatic dysfunction in a patient sample
US6502040B2 (en) 1997-12-31 2002-12-31 Biomerieux, Inc. Method for presenting thrombosis and hemostasis assay data
ES2162361T3 (es) * 1998-03-19 2001-12-16 Instrumentation Lab Spa Metodos, kits y reactivos mejorados para el muestreo de defectos de la coagulacion sanguinea.
US7632803B2 (en) * 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US20030130185A1 (en) * 2000-09-29 2003-07-10 David Bar-Or Metal-binding compounds and uses therefor
US7592304B2 (en) 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US6743596B1 (en) * 2000-10-27 2004-06-01 Biomerieux, Inc. Method of determining global coagulability hemostatic potential
EP1260817A3 (de) 2001-05-08 2002-12-18 Warner-Lambert Company Methode zur Direktbestimmung von Koagulationsfaktor VIIa in Plasma
WO2003007686A2 (en) * 2001-07-19 2003-01-30 Dmi Biosciences, Inc. Use of copper chelators to inhibit the inactivation of protein c
US6902904B2 (en) * 2001-08-27 2005-06-07 Pharmanetics Incorporated Coagulation assay reagents containing lanthanides
EP1367135A1 (de) * 2002-05-29 2003-12-03 Pentapharm AG Verbessertes Verfahren zur Beurteilung der Thrombinbildung in Blutplasma
US20040091952A1 (en) * 2002-07-25 2004-05-13 Sysmex Corporation Reagent kit for detecting lupus anticoagulant
US7727736B2 (en) * 2003-09-22 2010-06-01 The University Of North Carolina At Chapel Hill Soluble phospholipids for use in clotting factor assays
DE602005006633D1 (de) * 2004-02-06 2008-06-26 Sysmex Corp Reagenziensatz zum Nachweis von Lupus-Antikoagulant.
CA2592748C (en) * 2005-01-07 2014-04-22 Stichting Katholieke Universiteit Hemostasis assay
JP4639904B2 (ja) * 2005-03-30 2011-02-23 チッソ株式会社 蛍光活性を有するルシフェラーゼの活性増強方法
JP4609177B2 (ja) * 2005-04-28 2011-01-12 チッソ株式会社 カルシウム結合型発光蛋白質溶液の発光時間延長方法
US7957521B2 (en) * 2005-11-30 2011-06-07 On-Q Telecom Systems Co., Inc. Method and system for user prioritization within telecommunication services and in particular within call completion services
FR2908892B1 (fr) * 2006-11-21 2009-02-20 Hyphen Biomed Soc Par Actions Procede pour le dosage chromogenique de l'activite du facteur viii:c et necessaire de dosage chromogenique de l'activite du facteur viii:c,dans les plasmas ou les fractions therapeutiques
FR2909180B1 (fr) * 2006-11-29 2009-02-20 Diagnostica Stago Soc Par Acti Methode de mesure fonctionnelle de l'activite de la thrombomoduline plasmatique.
EP2313785B1 (de) * 2008-08-05 2016-02-17 Synapse B.V. Verfahren und Vorrichtung zur Messung der Erzeugung von Thrombin in Plasma
US9057574B2 (en) 2012-06-14 2015-06-16 Ra Brands, L.L.C. Thumb safety for model 1911 handgun
JP6595247B2 (ja) 2015-07-30 2019-10-23 シスメックス株式会社 凝固時間の測定方法およびその装置、凝固時間測定用試薬ならびに試薬キット
JP6577778B2 (ja) * 2015-07-30 2019-09-18 シスメックス株式会社 凝固時間の測定方法およびその装置、凝固時間測定用試薬ならびに試薬キット
CN110568117B (zh) * 2019-09-19 2022-03-22 青岛海洋生物医药研究院股份有限公司 一种多靶点抗血栓活性物质的液相色谱-质谱筛选方法
CN111707837A (zh) * 2020-05-29 2020-09-25 上海太阳生物技术有限公司 狼疮抗凝物确认试剂盒（凝固法）

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE203509C (de) *
DE3607559A1 (de) * 1986-03-07 1987-09-10 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet
US5055412A (en) * 1989-03-21 1991-10-08 Proksch Gary J Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same
SE464135B (sv) * 1989-07-14 1991-03-11 Kabivitrum Ab Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
US5308756A (en) * 1991-11-20 1994-05-03 Baxter Diagnostics Inc. Protein S chromogenic assay
US5637452A (en) * 1992-10-02 1997-06-10 Analytical Control Systems, Inc. Kit for an initial screen for abnormal platelet condition comprising propyl gallate or tannin and a metal ion
DE4402631A1 (de) * 1994-01-29 1995-08-03 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Gerinnungsparametern
EP0756638B1 (de) * 1994-04-22 2001-04-04 Stichting Sanquin Bloedvoorziening mittel für die behandlung von störungen des blutgerinnungsprozess
ATE290215T1 (de) * 1997-04-25 2005-03-15 Pentapharm Ag Verfahren zum funktionellen nachweis von störungen im protein c-system
DE19749197A1 (de) * 1997-11-07 1999-05-12 Dade Behring Marburg Gmbh Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe
AUPP159698A0 (en) * 1998-02-02 1998-02-26 Life Therapeutics Limited Improved blood coagulation test
US6245573B1 (en) * 1998-02-12 2001-06-12 University Of Medicine And Dentistry Of New Jersey Rapid assessment of the coagulant activity of blood
ES2162361T3 (es) * 1998-03-19 2001-12-16 Instrumentation Lab Spa Metodos, kits y reactivos mejorados para el muestreo de defectos de la coagulacion sanguinea.
US6743596B1 (en) * 2000-10-27 2004-06-01 Biomerieux, Inc. Method of determining global coagulability hemostatic potential
AU2002235073B2 (en) * 2001-03-02 2007-02-01 T.A.C. Thrombosis And Coagulation Ab Protein C variants
US6902904B2 (en) * 2001-08-27 2005-06-07 Pharmanetics Incorporated Coagulation assay reagents containing lanthanides

Also Published As

Publication number Publication date
WO1999047699A1 (en) 1999-09-23
DE69801210T2 (de) 2002-05-02
GR3036865T3 (en) 2002-01-31
ES2162361T3 (es) 2001-12-16
US20030199014A1 (en) 2003-10-23
US7118880B2 (en) 2006-10-10
EP0947585A1 (de) 1999-10-06
US20040235078A1 (en) 2004-11-25
AU2003212064A1 (en) 2003-08-14
US20020115127A1 (en) 2002-08-22
EP0947585B1 (de) 2001-07-25
CA2334935C (en) 2009-10-13
DK0947585T3 (da) 2001-10-01
US6800450B2 (en) 2004-10-05
US6395501B1 (en) 2002-05-28
AU3033999A (en) 1999-10-11
NZ506747A (en) 2003-03-28
DE69801210D1 (de) 2001-08-30
PT947585E (pt) 2001-11-30
US6730490B2 (en) 2004-05-04
CA2334935A1 (en) 1999-09-23
AU2003212064B2 (en) 2005-10-20
AU758831B2 (en) 2003-04-03
AU2003212064B9 (en) 2005-11-24

Similar Documents

Publication Publication Date Title
ATE203567T1 (de) Verbesserte in vitro verfahren, testkits und reagenzien zum screening von blutgerinnungsfehlern
DE502004008216D1 (de) Vorrichtung und verfahren zur simultanen durchführung von blutgruppenbestimmung, serumgegenprobe und antikörpersuch-test
TWI256975B (en) Compositions containing a urea derivative dye for detecting an analyte and methods for using the same
DE60315373D1 (de) Vorrichtung und Verfahren zur Bestimmung der Konzentration von Analyten
EA199800493A1 (ru) Анализ крови на соотношение активности фактора v для оценки вероятности заболевания тромбоэмболией
EP1221620A3 (de) Verfahren zum Ausführen einer Bestimmung der "activated clotting time" mit geringer Empfindlichkeit gegenüber die Anwesenheit des Aprotinins sowie zur Ermittlung der Aprotinin-Empfindlichkeit
DK173090D0 (da) Forbedrede ekstraktionsmetoder til fremstilling af thromboplastinreagenser
DK0830608T3 (da) Thromboseriskotest
DE69411898D1 (de) Neue antikoagulant-cofaktor aktivität
CA2162531A1 (en) Method for specifically detecting a coagulation factor v which has an increased stability toward activated protein c in the activated state
ATE333091T1 (de) Verfahren zur messung von blutersatzstoffen
DE60133510D1 (de) Automatisches Verfahren zur quantitativen Bestimmung und Überwachung von exogenem Hämoglobin in Vollblut, Blutplasma und Blutserum
DE59510217D1 (de) Verfahren zur Reduzierung der Beeinflussung von diagnostischen Tests durch Heparin unter Verwendung von Metallsalzen und diagnostisches Reagenz für diagnostische Tests zur Bestimmung der Gerinnungsfähigkeit des Blutes enthaltend Metallsalze
ES2107528T3 (es) Ensayos de la actividad de la amilina.
DK0587090T3 (da) Fremgangsmåde til bestemmelse af thromboseforårsagende lupus-antikoagulat-antistoffer.
Benattar et al. A new dilution for the modified APTT-based assay for activated protein C resistance: improvement of the reliability in patients with a lupus anticoagulant
EP4253963A3 (de) Klinisches entscheidungsunterstützungssystem
DE69520725D1 (de) Verfahren zur Diagnose von Blutgerinnungsstörungen
TH52313A (th) แถบทดสอบที่มีรีเอเจนต์สำหรับการกำหนดสารวิเคราะห์ออกมา
HUT60039A (en) Method for detecting allergy to food proteins and screening test set applicable for said method
HUT53229A (en) Process for radioimmunological determination of 3'-azido-3'-deoxythymidine content of biological samples

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee