DE69801210T2 - Verbesserte in vitro Verfahren, Testkits und Reagenzien zum Screening von Blutgerinnungsfehlern - Google Patents

Verbesserte in vitro Verfahren, Testkits und Reagenzien zum Screening von Blutgerinnungsfehlern

Info

Publication number
DE69801210T2
DE69801210T2 DE69801210T DE69801210T DE69801210T2 DE 69801210 T2 DE69801210 T2 DE 69801210T2 DE 69801210 T DE69801210 T DE 69801210T DE 69801210 T DE69801210 T DE 69801210T DE 69801210 T2 DE69801210 T2 DE 69801210T2
Authority
DE
Germany
Prior art keywords
reagents
coagulation
conversion rate
improved
blood clotting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69801210T
Other languages
English (en)
Other versions
DE69801210D1 (de
Inventor
Bert Steffen Rosen
Christina Maria Yvonne Hall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instrumentation Laboratory SpA
Original Assignee
Instrumentation Laboratory SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instrumentation Laboratory SpA filed Critical Instrumentation Laboratory SpA
Application granted granted Critical
Publication of DE69801210D1 publication Critical patent/DE69801210D1/de
Publication of DE69801210T2 publication Critical patent/DE69801210T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
DE69801210T 1998-03-19 1998-03-19 Verbesserte in vitro Verfahren, Testkits und Reagenzien zum Screening von Blutgerinnungsfehlern Expired - Lifetime DE69801210T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98105043A EP0947585B1 (de) 1998-03-19 1998-03-19 Verbesserte in vitro Verfahren, Testkits und Reagenzien zum Screening von Blutgerinnungsfehlern

Publications (2)

Publication Number Publication Date
DE69801210D1 DE69801210D1 (de) 2001-08-30
DE69801210T2 true DE69801210T2 (de) 2002-05-02

Family

ID=8231624

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69801210T Expired - Lifetime DE69801210T2 (de) 1998-03-19 1998-03-19 Verbesserte in vitro Verfahren, Testkits und Reagenzien zum Screening von Blutgerinnungsfehlern

Country Status (12)

Country Link
US (4) US6395501B1 (de)
EP (1) EP0947585B1 (de)
AT (1) ATE203567T1 (de)
AU (2) AU758831B2 (de)
CA (1) CA2334935C (de)
DE (1) DE69801210T2 (de)
DK (1) DK0947585T3 (de)
ES (1) ES2162361T3 (de)
GR (1) GR3036865T3 (de)
NZ (1) NZ506747A (de)
PT (1) PT947585E (de)
WO (1) WO1999047699A1 (de)

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US6321164B1 (en) 1995-06-07 2001-11-20 Akzo Nobel N.V. Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade
US6898532B1 (en) 1995-06-07 2005-05-24 Biomerieux, Inc. Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample
US6429017B1 (en) * 1999-02-04 2002-08-06 Biomerieux Method for predicting the presence of haemostatic dysfunction in a patient sample
US6502040B2 (en) 1997-12-31 2002-12-31 Biomerieux, Inc. Method for presenting thrombosis and hemostasis assay data
ES2162361T3 (es) * 1998-03-19 2001-12-16 Instrumentation Lab Spa Metodos, kits y reactivos mejorados para el muestreo de defectos de la coagulacion sanguinea.
US7632803B2 (en) * 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US20030130185A1 (en) * 2000-09-29 2003-07-10 David Bar-Or Metal-binding compounds and uses therefor
US7592304B2 (en) 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US6743596B1 (en) * 2000-10-27 2004-06-01 Biomerieux, Inc. Method of determining global coagulability hemostatic potential
EP1260817A3 (de) 2001-05-08 2002-12-18 Warner-Lambert Company Methode zur Direktbestimmung von Koagulationsfaktor VIIa in Plasma
US20030055003A1 (en) * 2001-07-19 2003-03-20 David Bar-Or Use of copper chelators to inhibit the inactivation of protein C
US6902904B2 (en) * 2001-08-27 2005-06-07 Pharmanetics Incorporated Coagulation assay reagents containing lanthanides
EP1367135A1 (de) * 2002-05-29 2003-12-03 Pentapharm AG Verbessertes Verfahren zur Beurteilung der Thrombinbildung in Blutplasma
US20040091952A1 (en) * 2002-07-25 2004-05-13 Sysmex Corporation Reagent kit for detecting lupus anticoagulant
WO2005031303A2 (en) * 2003-09-22 2005-04-07 University Of North Carolina At Chapel Hill Soluble phospholipids for use in clotting factor assays
DE602005006633D1 (de) * 2004-02-06 2008-06-26 Sysmex Corp Reagenziensatz zum Nachweis von Lupus-Antikoagulant.
EP1833982B1 (de) * 2005-01-07 2010-12-01 Stichting Katholieke Universiteit Blutstillungstest
JP4639904B2 (ja) * 2005-03-30 2011-02-23 チッソ株式会社 蛍光活性を有するルシフェラーゼの活性増強方法
JP4609177B2 (ja) * 2005-04-28 2011-01-12 チッソ株式会社 カルシウム結合型発光蛋白質溶液の発光時間延長方法
US7957521B2 (en) * 2005-11-30 2011-06-07 On-Q Telecom Systems Co., Inc. Method and system for user prioritization within telecommunication services and in particular within call completion services
FR2908892B1 (fr) * 2006-11-21 2009-02-20 Hyphen Biomed Soc Par Actions Procede pour le dosage chromogenique de l'activite du facteur viii:c et necessaire de dosage chromogenique de l'activite du facteur viii:c,dans les plasmas ou les fractions therapeutiques
FR2909180B1 (fr) * 2006-11-29 2009-02-20 Diagnostica Stago Soc Par Acti Methode de mesure fonctionnelle de l'activite de la thrombomoduline plasmatique.
EP2313785B1 (de) * 2008-08-05 2016-02-17 Synapse B.V. Verfahren und Vorrichtung zur Messung der Erzeugung von Thrombin in Plasma
US9057574B2 (en) 2012-06-14 2015-06-16 Ra Brands, L.L.C. Thumb safety for model 1911 handgun
JP6577778B2 (ja) * 2015-07-30 2019-09-18 シスメックス株式会社 凝固時間の測定方法およびその装置、凝固時間測定用試薬ならびに試薬キット
JP6595247B2 (ja) 2015-07-30 2019-10-23 シスメックス株式会社 凝固時間の測定方法およびその装置、凝固時間測定用試薬ならびに試薬キット
CN110568117B (zh) * 2019-09-19 2022-03-22 青岛海洋生物医药研究院股份有限公司 一种多靶点抗血栓活性物质的液相色谱-质谱筛选方法
CN111707837A (zh) * 2020-05-29 2020-09-25 上海太阳生物技术有限公司 狼疮抗凝物确认试剂盒（凝固法）

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DE203509C (de) *
DE3607559A1 (de) * 1986-03-07 1987-09-10 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet
US5055412A (en) * 1989-03-21 1991-10-08 Proksch Gary J Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same
SE464135B (sv) * 1989-07-14 1991-03-11 Kabivitrum Ab Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
US5308756A (en) * 1991-11-20 1994-05-03 Baxter Diagnostics Inc. Protein S chromogenic assay
US5637452A (en) * 1992-10-02 1997-06-10 Analytical Control Systems, Inc. Kit for an initial screen for abnormal platelet condition comprising propyl gallate or tannin and a metal ion
DE4402631A1 (de) * 1994-01-29 1995-08-03 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Gerinnungsparametern
DK0756638T3 (da) * 1994-04-22 2001-07-23 Sanquin Bloedvoorziening Midler til behandling af forstyrrelser i blodkoagulationskaskaden
CA2288080C (en) * 1997-04-25 2008-01-22 Pentapharm Ag Method for the functional detection of disorders in the protein c system
DE19749197A1 (de) * 1997-11-07 1999-05-12 Dade Behring Marburg Gmbh Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe
AUPP159698A0 (en) * 1998-02-02 1998-02-26 Life Therapeutics Limited Improved blood coagulation test
US6245573B1 (en) * 1998-02-12 2001-06-12 University Of Medicine And Dentistry Of New Jersey Rapid assessment of the coagulant activity of blood
ES2162361T3 (es) 1998-03-19 2001-12-16 Instrumentation Lab Spa Metodos, kits y reactivos mejorados para el muestreo de defectos de la coagulacion sanguinea.
US6743596B1 (en) * 2000-10-27 2004-06-01 Biomerieux, Inc. Method of determining global coagulability hemostatic potential
CA2440092A1 (en) * 2001-03-02 2002-09-12 T.A.C. Thrombosis And Coagulation Ab Protein c variants
US6902904B2 (en) * 2001-08-27 2005-06-07 Pharmanetics Incorporated Coagulation assay reagents containing lanthanides

Also Published As

Publication number Publication date
AU2003212064B2 (en) 2005-10-20
AU2003212064A1 (en) 2003-08-14
US6730490B2 (en) 2004-05-04
EP0947585B1 (de) 2001-07-25
DE69801210D1 (de) 2001-08-30
ATE203567T1 (de) 2001-08-15
NZ506747A (en) 2003-03-28
CA2334935A1 (en) 1999-09-23
CA2334935C (en) 2009-10-13
US6800450B2 (en) 2004-10-05
PT947585E (pt) 2001-11-30
AU2003212064B9 (en) 2005-11-24
DK0947585T3 (da) 2001-10-01
US20020115127A1 (en) 2002-08-22
US20040235078A1 (en) 2004-11-25
ES2162361T3 (es) 2001-12-16
US20030199014A1 (en) 2003-10-23
EP0947585A1 (de) 1999-10-06
AU758831B2 (en) 2003-04-03
US7118880B2 (en) 2006-10-10
AU3033999A (en) 1999-10-11
US6395501B1 (en) 2002-05-28
WO1999047699A1 (en) 1999-09-23
GR3036865T3 (en) 2002-01-31

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