UY40612A - Piridinas sustituidas con heteroarilo y métodos de uso - Google Patents

Piridinas sustituidas con heteroarilo y métodos de uso

Info

Publication number
UY40612A
UY40612A UY0001040612A UY40612A UY40612A UY 40612 A UY40612 A UY 40612A UY 0001040612 A UY0001040612 A UY 0001040612A UY 40612 A UY40612 A UY 40612A UY 40612 A UY40612 A UY 40612A
Authority
UY
Uruguay
Prior art keywords
methods
heteroaryl substituted
substituted pyridines
cystic fibrosis
compounds
Prior art date
Application number
UY0001040612A
Other languages
English (en)
Spanish (es)
Inventor
Hans Kelgtermans
J Altenbach Robert
Andrew Bogdan
Emiel Van Der Plas Steven
R Kym Philip
Petru Diunisu Coti Ghjuvanni
N Greszler Stephen
D Cowart Marlon
Xueqing Wang
Original Assignee
Abbvie Sarl
Galapagos Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Sarl, Galapagos Nv filed Critical Abbvie Sarl
Publication of UY40612A publication Critical patent/UY40612A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
UY0001040612A 2016-06-03 2017-06-02 Piridinas sustituidas con heteroarilo y métodos de uso UY40612A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662345315P 2016-06-03 2016-06-03
UY0001037272A UY37272A (es) 2016-06-03 2017-06-02 Piridinas sustituidas con heteroarilo y métodos de uso

Publications (1)

Publication Number Publication Date
UY40612A true UY40612A (es) 2024-02-15

Family

ID=59014678

Family Applications (2)

Application Number Title Priority Date Filing Date
UY0001040612A UY40612A (es) 2016-06-03 2017-06-02 Piridinas sustituidas con heteroarilo y métodos de uso
UY0001037272A UY37272A (es) 2016-06-03 2017-06-02 Piridinas sustituidas con heteroarilo y métodos de uso

Family Applications After (1)

Application Number Title Priority Date Filing Date
UY0001037272A UY37272A (es) 2016-06-03 2017-06-02 Piridinas sustituidas con heteroarilo y métodos de uso

Country Status (35)

Country Link
US (2) US10138227B2 (enExample)
EP (1) EP3464282B1 (enExample)
JP (3) JP6968094B2 (enExample)
KR (2) KR102719916B1 (enExample)
CN (2) CN114671864B (enExample)
AR (2) AR108672A1 (enExample)
AU (3) AU2017273215B2 (enExample)
CA (1) CA3022216A1 (enExample)
CL (1) CL2018003323A1 (enExample)
CO (1) CO2018012171A2 (enExample)
CR (1) CR20180547A (enExample)
CY (1) CY1124031T1 (enExample)
DK (1) DK3464282T3 (enExample)
DO (1) DOP2018000257A (enExample)
EC (1) ECSP18094790A (enExample)
ES (1) ES2806873T3 (enExample)
HR (1) HRP20201068T1 (enExample)
HU (1) HUE050248T2 (enExample)
IL (3) IL288243B2 (enExample)
LT (1) LT3464282T (enExample)
MX (2) MX385054B (enExample)
MY (1) MY199604A (enExample)
PE (1) PE20190511A1 (enExample)
PH (1) PH12018502534B1 (enExample)
PL (1) PL3464282T3 (enExample)
PT (1) PT3464282T (enExample)
RS (1) RS60574B1 (enExample)
RU (2) RU2756743C2 (enExample)
SG (1) SG11201808842VA (enExample)
SI (1) SI3464282T1 (enExample)
SM (1) SMT202000394T1 (enExample)
TW (4) TW202515560A (enExample)
UY (2) UY40612A (enExample)
WO (1) WO2017208115A1 (enExample)
ZA (1) ZA201808423B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100921397B1 (ko) * 2009-02-09 2009-10-14 (주)오엠티 인쇄회로기판의 세척장비 및 이를 이용한 세척방법
TWI735416B (zh) 2014-10-06 2021-08-11 美商維泰克斯製藥公司 囊腫纖維化症跨膜傳導調節蛋白之調節劑
US10138227B2 (en) * 2016-06-03 2018-11-27 Abbvie S.Á.R.L. Heteroaryl substituted pyridines and methods of use
EP3519401B1 (en) 2016-09-30 2021-09-29 Vertex Pharmaceuticals Incorporated Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
HUE052205T2 (hu) 2016-12-09 2021-04-28 Vertex Pharma Cisztás fibrózis transzmembrán vezetõképesség szabályzó modulátora, gyógyszerészeti készítmények, kezelési eljárások és eljárás a modulátor elõállítására
EP3558982A1 (en) 2016-12-20 2019-10-30 AbbVie S.À.R.L. Deuterated cftr modulators and methods of use
TW201831471A (zh) 2017-02-24 2018-09-01 盧森堡商艾伯維公司 囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法
CA3066084A1 (en) 2017-06-08 2018-12-13 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
US11517564B2 (en) 2017-07-17 2022-12-06 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
KR102606188B1 (ko) 2017-08-02 2023-11-23 버텍스 파마슈티칼스 인코포레이티드 피롤리딘 화합물을 제조하기 위한 공정
US10988454B2 (en) 2017-09-14 2021-04-27 Abbvie Overseas S.À.R.L. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
CA3078893A1 (en) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of cftr modulators
CA3085006A1 (en) 2017-12-08 2019-06-13 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
JP7214743B2 (ja) 2018-02-15 2023-01-30 バーテックス ファーマシューティカルズ インコーポレイテッド 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターとしての大環状分子、それらの医薬組成物、嚢胞性線維症の治療におけるそれらの使用、及びそれらの製造方法
US10710994B2 (en) * 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
WO2019193062A1 (en) 2018-04-03 2019-10-10 Abbvie S.Á.R.L Substituted pyrrolidines and their use
EP3774825A1 (en) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
IT201900000687A1 (it) 2019-01-16 2020-07-16 Fondazione St Italiano Tecnologia Composti e composizioni per il trattamento della fibrosi cistica
AR118555A1 (es) 2019-04-03 2021-10-20 Vertex Pharma Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística
EP3747882A1 (en) 2019-06-03 2020-12-09 AbbVie Overseas S.à r.l. Prodrug modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
US11236067B2 (en) 2019-07-12 2022-02-01 Orphomed, Inc. Compound for treating cystic fibrosis
HRP20240606T1 (hr) 2019-08-14 2024-07-19 Vertex Pharmaceuticals Incorporated Postupak za proizvodnju modulatora za cftr
TWI867024B (zh) 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
US11873300B2 (en) 2019-08-14 2024-01-16 Vertex Pharmaceuticals Incorporated Crystalline forms of CFTR modulators
WO2021097057A1 (en) * 2019-11-12 2021-05-20 Genzyme Corporation 5-membered heteroarylaminosulfonamides for treating conditions mediated by deficient cftr activity
KR20230052954A (ko) 2020-08-20 2023-04-20 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 점액 과다분비를 특징으로 하는 호흡기 질환의 치료 방법
IL303519A (en) 2020-12-10 2023-08-01 Vertex Pharma Cystic fibrosis treatment methods
WO2022150173A1 (en) 2021-01-06 2022-07-14 AbbVie Global Enterprises Ltd. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
EP4274828A1 (en) 2021-01-06 2023-11-15 AbbVie Global Enterprises Ltd. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
CN117813006A (zh) 2021-08-19 2024-04-02 先正达农作物保护股份公司 用于控制二酰胺抗性有害生物的方法及其化合物
CA3267795A1 (en) 2022-09-15 2024-03-21 Idorsia Pharmaceuticals Ltd MACROCYCLICAL CFTR MODULATORS
CA3267788A1 (en) 2022-09-15 2024-03-21 Idorsia Pharmaceuticals Ltd COMBINATION OF MACROCYCLIC CFTR MODULATORS WITH CFTR CORRECTORS AND/OR CFTR POTENTIALIZERS
CN116813569B (zh) * 2023-07-10 2024-07-02 衡阳市中心医院 一种抗癌药中间体的制备方法和抗癌药的制备方法
WO2025186214A1 (en) 2024-03-05 2025-09-12 Idorsia Pharmaceuticals Ltd Macrocyclic cftr modulators

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2561560A1 (en) * 2004-03-30 2005-10-13 The Regents Of The University Of California Hydrazide-containing cftr inhibitor compounds and uses thereof
US7939558B2 (en) 2004-06-04 2011-05-10 The Regents Of The University Of California Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
EP2532650A3 (en) 2004-06-24 2013-11-06 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8283351B2 (en) * 2007-04-02 2012-10-09 Institute For Oneworld Health Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof
HUE025553T2 (en) 2007-05-25 2016-02-29 Vertex Pharma CFTR modulators
CN101939054B (zh) 2007-12-10 2014-10-29 诺华股份有限公司 有机化合物
ES2422741T3 (es) 2007-12-13 2013-09-13 Vertex Pharma Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
CN102224141B (zh) 2008-10-23 2014-10-08 沃泰克斯药物股份有限公司 N-(4-(7-氮杂双环[2.2.1]庚-7-基)-2-(三氟甲基)苯基)-4-氧代-5-(三氟甲基)-1,4-二氢喹啉-3-甲酰胺的固体形式
US8513282B2 (en) * 2008-10-23 2013-08-20 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2010078103A1 (en) 2008-12-30 2010-07-08 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2011008931A2 (en) * 2009-07-15 2011-01-20 Cystic Fibrosis Foundation Therapeutics, Inc. Arylpyrimidine compounds and combination therapy comprising same for treating cystic fibrosis & related disorders
US8247436B2 (en) * 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
BR112013007907A2 (pt) 2010-10-08 2016-06-14 N30 Pharmaceuticals Inc novos compostos de quinolina substituída como inibidores de s-nitrosoglutationa reductase
WO2012154880A1 (en) * 2011-05-09 2012-11-15 Proteostasis Therapeutics, Inc. Proteostasis regulators for treating cystic fibrosis and other protein misfolding diseases
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038390A1 (en) 2011-09-16 2013-03-21 Novartis Ag N-substituted heterocyclyl carboxamides
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
ES2558457T3 (es) 2011-09-16 2016-02-04 Novartis Ag Compuestos heterocíclicos para el tratamiento de fibrosis quística
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
PT2760463T (pt) 2011-09-20 2019-02-27 Univ North Carolina Chapel Hill Regulação de canais de sódio por proteínas plunc
JP2016517895A (ja) 2013-05-07 2016-06-20 ガラパゴス・ナムローゼ・フェンノートシャップGalapagos N.V. 嚢胞性線維症を処置するための新規化合物およびこれらの医薬組成物
JP6425724B2 (ja) 2013-08-08 2018-11-21 ガラパゴス・ナムローゼ・フェンノートシャップGalapagos N.V. Cftrモジュレーターとしてのチエノ[2,3−c]ピラン
AU2015229188A1 (en) 2014-03-13 2016-09-29 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing CFTR activity
CA2942387A1 (en) 2014-03-13 2015-09-17 Proteostasis Therapeutics, Inc. Compounds, compositions and methods of increasing cftr actvity
HUE052373T2 (hu) 2014-10-31 2021-04-28 Abbvie Overseas Sarl Szubsztituált krománok és alkalmazási eljárások
EP3212184B1 (en) 2014-10-31 2020-04-01 AbbVie Overseas S.à r.l. Substituted benzotetrahydropyrans and their use
HK1249893A1 (zh) * 2015-03-31 2018-11-16 Vertex Pharmaceuticals (Europe) Limited 氘代vx-661
HK1253581A1 (zh) * 2015-06-02 2019-06-21 Abbvie S.A.R.L. 经取代的吡啶及使用方法
US9840513B2 (en) 2015-07-16 2017-12-12 Abbvie S.Á.R.L. Substituted tricyclics and method of use
JP2018530557A (ja) 2015-10-09 2018-10-18 アッヴィ・エス・ア・エール・エル 置換ピラゾロ[3,4−b]ピリジン−6−カルボン酸およびこの使用
JP6779992B2 (ja) 2015-10-09 2020-11-04 アッヴィ・エス・ア・エール・エル N−スルホニル化ピラゾロ[3,4−b]ピリジン−6−カルボキサミドおよび使用法
EP3448842A1 (en) 2016-04-26 2019-03-06 AbbVie S.À.R.L. Modulators of cystic fibrosis transmembrane conductance regulator protein
US10138227B2 (en) * 2016-06-03 2018-11-27 Abbvie S.Á.R.L. Heteroaryl substituted pyridines and methods of use

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JP7622122B2 (ja) 2025-01-27
AU2017273215A1 (en) 2018-10-25
SMT202000394T1 (it) 2020-09-10
CN109311864B (zh) 2022-05-10
IL262415B (en) 2021-12-01
AU2017273215B2 (en) 2021-09-09
JP2023172889A (ja) 2023-12-06
TW201802085A (zh) 2018-01-16
NZ788542A (en) 2025-06-27
HUE050248T2 (hu) 2020-12-28
EP3464282A1 (en) 2019-04-10
BR112018074815A2 (pt) 2019-03-19
AR124916A2 (es) 2023-05-17
PL3464282T3 (pl) 2020-12-14
CN114671864B (zh) 2025-04-08
AU2021282409A1 (en) 2021-12-23
EP3464282B1 (en) 2020-04-22
KR20190015215A (ko) 2019-02-13
TWI849782B (zh) 2024-07-21
US20190055229A1 (en) 2019-02-21
SI3464282T1 (sl) 2020-12-31
CO2018012171A2 (es) 2018-11-30
IL262415A (en) 2018-12-31
KR102719916B1 (ko) 2024-10-23
CA3022216A1 (en) 2017-12-07
AR108672A1 (es) 2018-09-12
AU2024202468A1 (en) 2024-05-02
CL2018003323A1 (es) 2019-03-22
ZA201808423B (en) 2019-08-28
CN109311864A (zh) 2019-02-05
RU2021127810A (ru) 2021-10-25
IL303196B2 (en) 2025-04-01
JP2022009448A (ja) 2022-01-14
PH12018502534B1 (en) 2020-09-23
PT3464282T (pt) 2020-07-17
RS60574B1 (sr) 2020-08-31
MX385054B (es) 2025-03-14
TW202515560A (zh) 2025-04-16
CN114671864A (zh) 2022-06-28
IL303196B1 (en) 2024-12-01
AU2021282409B2 (en) 2024-01-18
US10604515B2 (en) 2020-03-31
HRP20201068T1 (hr) 2020-11-13
DK3464282T3 (da) 2020-07-27
IL303196A (en) 2023-07-01
IL288243B2 (en) 2023-11-01
JP2019517455A (ja) 2019-06-24
LT3464282T (lt) 2020-09-10
SG11201808842VA (en) 2018-11-29
JP7392211B2 (ja) 2023-12-06
DOP2018000257A (es) 2018-12-31
RU2018138707A (ru) 2020-07-14
ES2806873T3 (es) 2021-02-18
UY37272A (es) 2018-01-02
CY1124031T1 (el) 2022-03-24
RU2018138707A3 (enExample) 2020-08-24
MY199604A (en) 2023-11-08
PH12018502534A1 (en) 2019-10-21
IL288243A (en) 2022-01-01
NZ747222A (en) 2025-06-27
JP6968094B2 (ja) 2021-11-17
KR20220162806A (ko) 2022-12-08
TW202329959A (zh) 2023-08-01
MX2021009322A (es) 2021-09-08
TWI752961B (zh) 2022-01-21
CR20180547A (es) 2019-10-30
RU2756743C2 (ru) 2021-10-05
US10138227B2 (en) 2018-11-27
TW202214614A (zh) 2022-04-16
ECSP18094790A (es) 2019-01-31
TWI797926B (zh) 2023-04-01
PE20190511A1 (es) 2019-04-10
IL288243B1 (en) 2023-07-01
WO2017208115A1 (en) 2017-12-07
US20170349576A1 (en) 2017-12-07
KR102469995B1 (ko) 2022-11-24
MX2018014758A (es) 2019-04-29

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