ES2806873T3 - Piridinas sustituidas con heteroarilo y métodos de uso - Google Patents

Piridinas sustituidas con heteroarilo y métodos de uso Download PDF

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Publication number
ES2806873T3
ES2806873T3 ES17728272T ES17728272T ES2806873T3 ES 2806873 T3 ES2806873 T3 ES 2806873T3 ES 17728272 T ES17728272 T ES 17728272T ES 17728272 T ES17728272 T ES 17728272T ES 2806873 T3 ES2806873 T3 ES 2806873T3
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ES
Spain
Prior art keywords
independently selected
sulfonyl
optionally substituted
trifluoromethoxy
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES17728272T
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English (en)
Spanish (es)
Inventor
Robert J Altenbach
Andrew Bogdan
Ghjuvanni Petru Diunisu Coti
Marlon D Cowart
Stephen N Greszler
Hans Kelgtermans
Philip R Kym
Der Plas Steven Emiel Van
Xueqing Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galapagos NV
AbbVie Overseas SARL
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Galapagos NV
AbbVie Overseas SARL
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Publication of ES2806873T3 publication Critical patent/ES2806873T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES17728272T 2016-06-03 2017-05-24 Piridinas sustituidas con heteroarilo y métodos de uso Active ES2806873T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662345315P 2016-06-03 2016-06-03
PCT/IB2017/053068 WO2017208115A1 (en) 2016-06-03 2017-05-24 Heteroaryl substituted pyridines and methods of use

Publications (1)

Publication Number Publication Date
ES2806873T3 true ES2806873T3 (es) 2021-02-18

Family

ID=59014678

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17728272T Active ES2806873T3 (es) 2016-06-03 2017-05-24 Piridinas sustituidas con heteroarilo y métodos de uso

Country Status (35)

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US (2) US10138227B2 (enExample)
EP (1) EP3464282B1 (enExample)
JP (3) JP6968094B2 (enExample)
KR (2) KR102469995B1 (enExample)
CN (2) CN114671864B (enExample)
AR (2) AR108672A1 (enExample)
AU (3) AU2017273215B2 (enExample)
CA (1) CA3022216A1 (enExample)
CL (1) CL2018003323A1 (enExample)
CO (1) CO2018012171A2 (enExample)
CR (1) CR20180547A (enExample)
CY (1) CY1124031T1 (enExample)
DK (1) DK3464282T3 (enExample)
DO (1) DOP2018000257A (enExample)
EC (1) ECSP18094790A (enExample)
ES (1) ES2806873T3 (enExample)
HR (1) HRP20201068T1 (enExample)
HU (1) HUE050248T2 (enExample)
IL (3) IL288243B2 (enExample)
LT (1) LT3464282T (enExample)
MX (2) MX385054B (enExample)
MY (1) MY199604A (enExample)
PE (1) PE20190511A1 (enExample)
PH (1) PH12018502534B1 (enExample)
PL (1) PL3464282T3 (enExample)
PT (1) PT3464282T (enExample)
RS (1) RS60574B1 (enExample)
RU (2) RU2021127810A (enExample)
SG (1) SG11201808842VA (enExample)
SI (1) SI3464282T1 (enExample)
SM (1) SMT202000394T1 (enExample)
TW (4) TW202515560A (enExample)
UY (2) UY37272A (enExample)
WO (1) WO2017208115A1 (enExample)
ZA (1) ZA201808423B (enExample)

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PE20190511A1 (es) 2019-04-10
JP7622122B2 (ja) 2025-01-27
RU2018138707A (ru) 2020-07-14
CN109311864A (zh) 2019-02-05
JP7392211B2 (ja) 2023-12-06
CN114671864A (zh) 2022-06-28
CR20180547A (es) 2019-10-30
US10604515B2 (en) 2020-03-31
TW202515560A (zh) 2025-04-16
IL303196B1 (en) 2024-12-01
DK3464282T3 (da) 2020-07-27
IL303196A (en) 2023-07-01
PH12018502534B1 (en) 2020-09-23
IL288243B2 (en) 2023-11-01
WO2017208115A1 (en) 2017-12-07
US10138227B2 (en) 2018-11-27
TWI849782B (zh) 2024-07-21
NZ747222A (en) 2025-06-27
JP2023172889A (ja) 2023-12-06
RS60574B1 (sr) 2020-08-31
AU2017273215B2 (en) 2021-09-09
IL303196B2 (en) 2025-04-01
AR108672A1 (es) 2018-09-12
AU2024202468A1 (en) 2024-05-02
KR20220162806A (ko) 2022-12-08
ECSP18094790A (es) 2019-01-31
PL3464282T3 (pl) 2020-12-14
CY1124031T1 (el) 2022-03-24
TWI797926B (zh) 2023-04-01
MX2021009322A (es) 2021-09-08
NZ788542A (en) 2025-06-27
TW202214614A (zh) 2022-04-16
HRP20201068T1 (hr) 2020-11-13
MY199604A (en) 2023-11-08
DOP2018000257A (es) 2018-12-31
KR102469995B1 (ko) 2022-11-24
BR112018074815A2 (pt) 2019-03-19
CN109311864B (zh) 2022-05-10
UY40612A (es) 2024-02-15
TWI752961B (zh) 2022-01-21
AU2021282409A1 (en) 2021-12-23
SG11201808842VA (en) 2018-11-29
CL2018003323A1 (es) 2019-03-22
AU2017273215A1 (en) 2018-10-25
PT3464282T (pt) 2020-07-17
UY37272A (es) 2018-01-02
SMT202000394T1 (it) 2020-09-10
SI3464282T1 (sl) 2020-12-31
LT3464282T (lt) 2020-09-10
KR20190015215A (ko) 2019-02-13
KR102719916B1 (ko) 2024-10-23
AU2021282409B2 (en) 2024-01-18
JP2022009448A (ja) 2022-01-14
ZA201808423B (en) 2019-08-28
TW202329959A (zh) 2023-08-01
MX385054B (es) 2025-03-14
HUE050248T2 (hu) 2020-12-28
CA3022216A1 (en) 2017-12-07
IL262415A (en) 2018-12-31
EP3464282A1 (en) 2019-04-10
RU2021127810A (ru) 2021-10-25
PH12018502534A1 (en) 2019-10-21
AR124916A2 (es) 2023-05-17
EP3464282B1 (en) 2020-04-22
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