UY38998A - Derivados de bencimidazol, su uso en medicina y composiciones que los contienen - Google Patents

Derivados de bencimidazol, su uso en medicina y composiciones que los contienen

Info

Publication number
UY38998A
UY38998A UY0001038998A UY38998A UY38998A UY 38998 A UY38998 A UY 38998A UY 0001038998 A UY0001038998 A UY 0001038998A UY 38998 A UY38998 A UY 38998A UY 38998 A UY38998 A UY 38998A
Authority
UY
Uruguay
Prior art keywords
medicine
compositions containing
benzimidazole derivatives
benzimidazoles
processes
Prior art date
Application number
UY0001038998A
Other languages
English (en)
Inventor
Agustin Casimiro-Garcia
Frank Eldridge Lovering
Brian Stephen Gerstenberger
John Isidro Trujillo
Mihir Dineshkumar Parikh
Scott William Bagley
Xiayun Cheng
Rajiah Aldrin Denny
Jennifer Elizabeth Davoren
Joseph Walter Strohbach
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY38998A publication Critical patent/UY38998A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a bencimidazoles de la Fórmula (I) y sales de estos aceptables desde el punto de vista farmacéutico, en donde R1 a R6 son como se definen en la descripción; a su uso en la medicina; a composiciones que los contienen; a procesos para su preparación; y a intermediarios usados en dichos procesos. Los bencimidazoles de la Fórmula (I) son inhibidores de ITK y, por lo tanto, son potencialmente útiles en el tratamiento de diversos trastornos, que incluyen dermatitis atópica.
UY0001038998A 2019-12-20 2020-12-21 Derivados de bencimidazol, su uso en medicina y composiciones que los contienen UY38998A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962951030P 2019-12-20 2019-12-20
US202063108602P 2020-11-02 2020-11-02

Publications (1)

Publication Number Publication Date
UY38998A true UY38998A (es) 2021-07-30

Family

ID=73856233

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001038998A UY38998A (es) 2019-12-20 2020-12-21 Derivados de bencimidazol, su uso en medicina y composiciones que los contienen

Country Status (19)

Country Link
US (1) US11661419B2 (es)
EP (1) EP4077316A1 (es)
JP (1) JP2023507138A (es)
KR (1) KR20220118525A (es)
CN (1) CN115087655A (es)
AU (1) AU2020405536B2 (es)
BR (1) BR112022011838A2 (es)
CA (1) CA3103120A1 (es)
CL (1) CL2022001675A1 (es)
CO (1) CO2022008313A2 (es)
CR (1) CR20220299A (es)
DO (1) DOP2022000130A (es)
EC (1) ECSP22049160A (es)
IL (1) IL293831B2 (es)
MX (1) MX2022007518A (es)
PE (1) PE20221916A1 (es)
TW (1) TWI766484B (es)
UY (1) UY38998A (es)
WO (1) WO2021124155A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4263526A1 (en) * 2020-12-15 2023-10-25 Pfizer Inc. Benzimidazole derivatives and their use as inhibitors of itk for the treatment of skin disease
CN114624358A (zh) * 2022-03-11 2022-06-14 哈尔滨圣泰生物制药有限公司 一种地氯雷他定口服液的质量检测方法
WO2023249992A2 (en) * 2022-06-21 2023-12-28 Jjr&D, Llc Topical benzimidazole formulations and methods for use in treating inflammatory dermatoses

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0901786B1 (en) 1997-08-11 2007-06-13 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailability
GB9911053D0 (en) 1999-05-12 1999-07-14 Pharmacia & Upjohn Spa 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
MXPA04003954A (es) * 2001-10-26 2004-11-29 Aventis Pharma Inc Bencimidazoles.
FR2831536A1 (fr) 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
JP2003231687A (ja) 2002-02-04 2003-08-19 Japan Tobacco Inc ピラゾリル縮合環化合物及びその医薬用途
WO2005105788A1 (en) 2004-04-23 2005-11-10 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
CN101160312A (zh) 2005-04-14 2008-04-09 霍夫曼-拉罗奇有限公司 三环吡咯衍生物、它们的制备和作为药剂的应用
GB0602178D0 (en) 2006-02-03 2006-03-15 Merck Sharp & Dohme Therapeutic treatment
US20080070933A1 (en) 2006-08-24 2008-03-20 Huang Kenneth H Purine, Pyrimidine, and Azaindole Derivatives
ATE522536T1 (de) 2008-02-25 2011-09-15 Hoffmann La Roche Pyrrolopyrazin-kinasehemmer
CN101945877B (zh) 2008-02-25 2013-07-03 霍夫曼-拉罗奇有限公司 吡咯并吡嗪激酶抑制剂
MX2010009023A (es) 2008-02-25 2010-09-07 Hoffmann La Roche Inhibidores de cinasas de pirrolopirazina.
CA2713710A1 (en) 2008-02-25 2009-09-03 F. Hoffmann-La Roche Ag Pyrrolopyrazine kinase inhibitors
ATE522534T1 (de) 2008-02-25 2011-09-15 Hoffmann La Roche Pyrrolopyrazin-kinasehemmer
EP2196458A1 (en) 2008-12-10 2010-06-16 Laboratorios Del. Dr. Esteve, S.A. Process for obtaining enantiomerically enriched pyrazole derivatives
EP2202232A1 (en) 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. 1,2,4-oxadiazole derivatives and their therapeutic use
EP2292237A1 (en) 2009-08-14 2011-03-09 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention or treatment of pain induced by chemotherapy
US8299070B2 (en) 2009-11-25 2012-10-30 Japan Tobacco Inc. Indole compounds and pharmaceutical use thereof
EP2366702A1 (en) 2010-03-18 2011-09-21 Almirall, S.A. New oxadiazole derivatives
US8481541B2 (en) 2010-03-22 2013-07-09 Hoffmann-La Roche Inc. Pyrrolopyrazine kinase inhibitors
CN102906095A (zh) 2010-05-20 2013-01-30 弗·哈夫曼-拉罗切有限公司 作为syk和jak抑制剂的吡咯并吡嗪衍生物
TR201821217T4 (tr) * 2010-06-23 2019-01-21 Hanmi Science Co Ltd Tirozin kinaz aktivitesinin inhibisyonu için yeni kaynaşmış pirimidin türevleri.
EP2615916B1 (en) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel erk inhibitors
EP2455081A1 (en) 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of crohn's disease
EP2455080A1 (en) 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of multiple sclerosis
MA34948B1 (fr) 2011-02-07 2014-03-01 Plexxikon Inc Composes et procedes de modulation de kinase, et leurs indications
MX2014001595A (es) 2011-08-12 2014-04-14 Hoffmann La Roche Compuestos de imidazol, composiciones y metodos de uso.
JP6096778B2 (ja) 2011-09-01 2017-03-15 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ピロロピラジンキナーゼ阻害剤
JP2015528435A (ja) 2012-08-10 2015-09-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ピラゾールカルボキサミド化合物、組成物及び使用方法
WO2014041518A1 (en) 2012-09-14 2014-03-20 Glenmark Pharmaceuticals S.A. Thienopyrrole derivatives as itk inhibitors
DK2900657T3 (da) 2012-09-26 2020-05-04 Hoffmann La Roche Cykliske etherpyrazol-4-yl-heterocyclyl-carboxamidforbindelser og fremgangsmåder til anvendelse
CN103804364A (zh) 2012-11-06 2014-05-21 韩冰 一类治疗缺血性脑损伤的化合物及其用途
CN103800328A (zh) 2012-11-07 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
CN103800337A (zh) 2012-11-07 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
CN103804291A (zh) 2012-11-07 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
CN103804361A (zh) 2012-11-07 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
CN103800340A (zh) 2012-11-09 2014-05-21 韩冰 一类治疗青光眼的化合物及其用途
CN103800327A (zh) 2012-11-09 2014-05-21 韩冰 一类治疗青光眼的化合物及其用途
CN103804302A (zh) 2012-11-14 2014-05-21 杨育新 一类治疗创伤性脑损伤疾病的化合物及其用途
CN103804351A (zh) 2012-11-14 2014-05-21 韩冰 一类具有神经保护作用的化合物及其用途
CN103804363A (zh) 2012-11-14 2014-05-21 韩冰 一类具有神经保护作用的化合物及其用途
CN103804272A (zh) 2012-11-14 2014-05-21 韩冰 一类具有神经保护作用的化合物及其用途
CN104628657A (zh) 2013-11-06 2015-05-20 韩冰 一类治疗缺血性脑损伤的化合物及其用途
WO2016001341A1 (en) 2014-07-03 2016-01-07 F. Hoffmann-La Roche Ag Sulfonylaminopyridine compounds, compositions and methods of use
CN110845482B (zh) 2014-07-04 2024-01-19 日本烟草产业株式会社 制备吲哚化合物的方法
WO2016010108A1 (ja) 2014-07-18 2016-01-21 塩野義製薬株式会社 含窒素複素環誘導体およびそれらを含有する医薬組成物
CN105524067A (zh) 2014-09-28 2016-04-27 江苏柯菲平医药股份有限公司 4-取代吡咯并[2,3-d]嘧啶化合物及其用途
WO2016091916A1 (en) 2014-12-10 2016-06-16 F. Hoffmann-La Roche Ag Pyrazolylaminopurines as itk inhibitors
WO2016115455A2 (en) 2015-01-15 2016-07-21 University Of Pittsburgh - Of The Commonwealth System Of Higher Education 6-aryl-7-substituted-3-(1h-pyrazol-5-yl)-7h-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as inhibitors of the stat3 pathway with anti-proliferative activity
AU2016287581B2 (en) 2015-07-02 2019-06-06 F. Hoffmann-La Roche Ag Bicyclic lactams and methods of use thereof
MX2020012644A (es) 2018-05-25 2021-01-29 Japan Tobacco Inc Metodo para tratar dolor o cistitis intersticial utilizando compuesto de indol.
US12011448B2 (en) 2018-05-25 2024-06-18 Japan Tobacco Inc. Therapeutic or preventing agent for nephrotic syndrome including indole compound
US20210236503A1 (en) 2018-05-25 2021-08-05 Japan Tobacco Inc. Therapeutic or preventing agent for multiple sclerosis including indole compound
EP4263526A1 (en) * 2020-12-15 2023-10-25 Pfizer Inc. Benzimidazole derivatives and their use as inhibitors of itk for the treatment of skin disease

Also Published As

Publication number Publication date
CR20220299A (es) 2022-08-05
DOP2022000130A (es) 2022-07-31
CL2022001675A1 (es) 2023-03-17
JP2023507138A (ja) 2023-02-21
WO2021124155A1 (en) 2021-06-24
IL293831B1 (en) 2023-10-01
EP4077316A1 (en) 2022-10-26
TWI766484B (zh) 2022-06-01
CA3103120A1 (en) 2021-06-20
CO2022008313A2 (es) 2022-07-08
AU2020405536B2 (en) 2023-09-07
BR112022011838A2 (pt) 2022-08-30
IL293831A (en) 2022-08-01
ECSP22049160A (es) 2022-07-29
PE20221916A1 (es) 2022-12-23
IL293831B2 (en) 2024-02-01
AU2020405536A1 (en) 2022-07-14
US11661419B2 (en) 2023-05-30
KR20220118525A (ko) 2022-08-25
MX2022007518A (es) 2022-09-19
CN115087655A (zh) 2022-09-20
TW202130634A (zh) 2021-08-16
US20210188829A1 (en) 2021-06-24

Similar Documents

Publication Publication Date Title
CL2019001077A1 (es) Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer.
ECSP20070854A (es) Compuestos heteroaril tetracíclicos
UY38001A (es) Compuestos que inhiben las proteínas ras mutantes g12c
UY38998A (es) Derivados de bencimidazol, su uso en medicina y composiciones que los contienen
UY38076A (es) Derivados de tetrahidroquinazolina útiles como agentes anticáncer
CO2017009891A2 (es) Inhibidores de inhibidores del factor beta de crecimiento de transformación (tgf-beta)
CO2018004857A2 (es) Derivados de dihidroimidazopirazinona usados en el tratamiento del cáncer
UY36244A (es) Derivados de la pirimidinona como inhibidores del factor xia y/o de la calicreína plasmática y composiciones farmacéuticas que los contienen
SV2016005171A (es) Derivados de quinolizina sustituidos útiles como inhibidores de integrasa del vih
NI201500048A (es) Derivados de 5-fenoxi-3h-pirimidin-4-ona y su uso como inhibidores de la transcriptasa inversa del vih
UY36649A (es) Inhibidores de la replicación del virus de la inmunodeficiencia humana
CL2021001190A1 (es) Compuestos de azalactam como inhibidores de hpk1
ECSP17007208A (es) Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble
UY35535A (es) ?Derivados de fenil sulfonamidas?.
UY36003A (es) Derivados de amida, procesos de preparación y composiciones, útiles en afecciones asociadas con el receptor sub-tipo 1 de orexina.
UY35275A (es) Derivados de aminopirazina
CL2019001991A1 (es) Moduladores del receptor de estrógeno.
CO2020004977A2 (es) Compuestos bicíclicos para su uso como inhibidores de la ripi quinasa
CR20160084A (es) Derivados de amida como agonistas del receptor del ácido lisofosfatídico
CR20180091A (es) 5-(n-bencil-tetrahidroisoquinolin-6-il)-piridin-3-il acético como inhibidores de la replicación del vih
UY35536A (es) ?derivados de sulfonamida?.
ECSP21037191A (es) Pirazoles como moduladores de la hemoglobina
CO2021001925A2 (es) Piridopirimidinas como inhibidores del receptor de histamina h4
ECSP18056196A (es) Derivados de indano
DOP2022000203A (es) 3-fenoxiazetidin-1-il-pirazinas sustituidas con actividad antagonista gpr52