ECSP22049160A - Derivados de bencimidazol - Google Patents
Derivados de bencimidazolInfo
- Publication number
- ECSP22049160A ECSP22049160A ECSENADI202249160A ECDI202249160A ECSP22049160A EC SP22049160 A ECSP22049160 A EC SP22049160A EC SENADI202249160 A ECSENADI202249160 A EC SENADI202249160A EC DI202249160 A ECDI202249160 A EC DI202249160A EC SP22049160 A ECSP22049160 A EC SP22049160A
- Authority
- EC
- Ecuador
- Prior art keywords
- benzimidazole derivatives
- benzimidazoles
- processes
- formula
- medicine
- Prior art date
Links
- 150000001556 benzimidazoles Chemical class 0.000 title abstract 3
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invenci?n se refiere a bencimidazoles de la F?rmula (I) y sales de estos aceptables desde el punto de vista farmac?utico, en donde R1 a R6 son como se definen en la descripci?n; a su uso en la medicina; a composiciones que los contienen; a procesos para su preparaci?n; y a intermediarios usados en dichos procesos. Los bencimidazoles de la F?rmula (I) son inhibidores de ITK y, por lo tanto, son potencialmente ?tiles en el tratamiento de diversos trastornos, que incluyen dermatitis at?pica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962951030P | 2019-12-20 | 2019-12-20 | |
US202063108602P | 2020-11-02 | 2020-11-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP22049160A true ECSP22049160A (es) | 2022-07-29 |
Family
ID=73856233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI202249160A ECSP22049160A (es) | 2019-12-20 | 2022-06-20 | Derivados de bencimidazol |
Country Status (19)
Country | Link |
---|---|
US (1) | US11661419B2 (es) |
EP (1) | EP4077316A1 (es) |
JP (1) | JP2023507138A (es) |
KR (1) | KR20220118525A (es) |
CN (1) | CN115087655A (es) |
AU (1) | AU2020405536B2 (es) |
BR (1) | BR112022011838A2 (es) |
CA (1) | CA3103120A1 (es) |
CL (1) | CL2022001675A1 (es) |
CO (1) | CO2022008313A2 (es) |
CR (1) | CR20220299A (es) |
DO (1) | DOP2022000130A (es) |
EC (1) | ECSP22049160A (es) |
IL (1) | IL293831B2 (es) |
MX (1) | MX2022007518A (es) |
PE (1) | PE20221916A1 (es) |
TW (1) | TWI766484B (es) |
UY (1) | UY38998A (es) |
WO (1) | WO2021124155A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022130171A1 (en) * | 2020-12-15 | 2022-06-23 | Pfizer Inc. | Benzimidazole derivatives and their use as inhibitors of itk for the treatment of skin disease |
CN114624358A (zh) * | 2022-03-11 | 2022-06-14 | 哈尔滨圣泰生物制药有限公司 | 一种地氯雷他定口服液的质量检测方法 |
WO2023249992A2 (en) * | 2022-06-21 | 2023-12-28 | Jjr&D, Llc | Topical benzimidazole formulations and methods for use in treating inflammatory dermatoses |
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GB9911053D0 (en) | 1999-05-12 | 1999-07-14 | Pharmacia & Upjohn Spa | 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents |
FR2831536A1 (fr) | 2001-10-26 | 2003-05-02 | Aventis Pharma Sa | Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr |
IL161576A0 (en) * | 2001-10-26 | 2004-09-27 | Aventis Pharma Inc | Benzimidazoles and analogues and their use as protein kinases inhibitors |
JP2003231687A (ja) | 2002-02-04 | 2003-08-19 | Japan Tobacco Inc | ピラゾリル縮合環化合物及びその医薬用途 |
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EP1885725B1 (en) | 2005-04-14 | 2008-09-24 | F.Hoffmann-La Roche Ag | Tricyclic azole derivatives, their manufacture and use as pharmaceutical agents |
GB0602178D0 (en) | 2006-02-03 | 2006-03-15 | Merck Sharp & Dohme | Therapeutic treatment |
US20080070933A1 (en) | 2006-08-24 | 2008-03-20 | Huang Kenneth H | Purine, Pyrimidine, and Azaindole Derivatives |
WO2009106441A1 (en) | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
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EP2250172B1 (en) | 2008-02-25 | 2011-08-31 | F. Hoffmann-La Roche AG | Pyrrolopyrazine kinase inhibitors |
JP5485178B2 (ja) | 2008-02-25 | 2014-05-07 | エフ.ホフマン−ラ ロシュ アーゲー | ピロロピラジンキナーゼ阻害剤 |
ATE519763T1 (de) | 2008-02-25 | 2011-08-15 | Hoffmann La Roche | Pyrrolopyrazin-kinasehemmer |
EP2196458A1 (en) | 2008-12-10 | 2010-06-16 | Laboratorios Del. Dr. Esteve, S.A. | Process for obtaining enantiomerically enriched pyrazole derivatives |
EP2202232A1 (en) | 2008-12-26 | 2010-06-30 | Laboratorios Almirall, S.A. | 1,2,4-oxadiazole derivatives and their therapeutic use |
EP2292237A1 (en) | 2009-08-14 | 2011-03-09 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
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EP2366702A1 (en) | 2010-03-18 | 2011-09-21 | Almirall, S.A. | New oxadiazole derivatives |
US8481541B2 (en) | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
WO2011144584A1 (en) | 2010-05-20 | 2011-11-24 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine derivatives as syk and jak inhibitors |
HUE042165T2 (hu) * | 2010-06-23 | 2019-06-28 | Hanmi Science Co Ltd | Új fuzionált pirimidin-származékok a tirozin kináz aktivitás gátlására |
WO2012036997A1 (en) | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
EP2455080A1 (en) | 2010-11-23 | 2012-05-23 | Almirall, S.A. | S1P1 receptor agonists for use in the treatment of multiple sclerosis |
EP2455081A1 (en) | 2010-11-23 | 2012-05-23 | Almirall, S.A. | S1P1 receptor agonists for use in the treatment of crohn's disease |
MY162950A (en) | 2011-02-07 | 2017-07-31 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
MX2014001595A (es) | 2011-08-12 | 2014-04-14 | Hoffmann La Roche | Compuestos de imidazol, composiciones y metodos de uso. |
KR20140074912A (ko) | 2011-09-01 | 2014-06-18 | 에프. 호프만-라 로슈 아게 | 피롤로피라진 키나아제 억제제 |
EP2882718A4 (en) | 2012-08-10 | 2015-12-23 | Hoffmann La Roche | PYRAZOLE CARBOXAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
WO2014041518A1 (en) | 2012-09-14 | 2014-03-20 | Glenmark Pharmaceuticals S.A. | Thienopyrrole derivatives as itk inhibitors |
KR102281288B1 (ko) | 2012-09-26 | 2021-07-26 | 에프. 호프만-라 로슈 아게 | 환형 에터 피라졸-4-일-헤테로사이클릴-카복사마이드 화합물 및 이의 사용 방법 |
CN103804364A (zh) | 2012-11-06 | 2014-05-21 | 韩冰 | 一类治疗缺血性脑损伤的化合物及其用途 |
CN103804361A (zh) | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103800328A (zh) | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
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CN105524067A (zh) | 2014-09-28 | 2016-04-27 | 江苏柯菲平医药股份有限公司 | 4-取代吡咯并[2,3-d]嘧啶化合物及其用途 |
WO2016091916A1 (en) | 2014-12-10 | 2016-06-16 | F. Hoffmann-La Roche Ag | Pyrazolylaminopurines as itk inhibitors |
US10618914B2 (en) | 2015-01-15 | 2020-04-14 | University of Pittsburgh—of the Commonwealth System of Higher Education | 6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-B][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity |
CN112979660A (zh) | 2015-07-02 | 2021-06-18 | 豪夫迈·罗氏有限公司 | 二环内酰胺和其应用方法 |
BR112020022377A2 (pt) | 2018-05-25 | 2021-02-02 | Japan Tobacco, Inc. | método para o tratamento da dor ou cistite intersticial usando um composto indol |
CN112135615B (zh) | 2018-05-25 | 2023-10-31 | 日本烟草产业株式会社 | 包含吲哚类化合物的肾病综合征治疗或预防剂 |
EP3804726A4 (en) | 2018-05-25 | 2022-03-16 | Japan Tobacco Inc. | THERAPEUTIC OR PROPHYLACTIC AGENT FOR MULTIPLE SCLEROSIS CONTAINING AN INDOLE COMPOUND |
WO2022130171A1 (en) * | 2020-12-15 | 2022-06-23 | Pfizer Inc. | Benzimidazole derivatives and their use as inhibitors of itk for the treatment of skin disease |
-
2020
- 2020-12-16 KR KR1020227025150A patent/KR20220118525A/ko not_active Application Discontinuation
- 2020-12-16 WO PCT/IB2020/062036 patent/WO2021124155A1/en active Application Filing
- 2020-12-16 JP JP2022537036A patent/JP2023507138A/ja active Pending
- 2020-12-16 MX MX2022007518A patent/MX2022007518A/es unknown
- 2020-12-16 AU AU2020405536A patent/AU2020405536B2/en active Active
- 2020-12-16 EP EP20828341.6A patent/EP4077316A1/en active Pending
- 2020-12-16 CN CN202080096751.1A patent/CN115087655A/zh active Pending
- 2020-12-16 CR CR20220299A patent/CR20220299A/es unknown
- 2020-12-16 BR BR112022011838A patent/BR112022011838A2/pt not_active Application Discontinuation
- 2020-12-16 IL IL293831A patent/IL293831B2/en unknown
- 2020-12-16 PE PE2022001143A patent/PE20221916A1/es unknown
- 2020-12-17 CA CA3103120A patent/CA3103120A1/en active Pending
- 2020-12-18 US US17/126,358 patent/US11661419B2/en active Active
- 2020-12-18 TW TW109144868A patent/TWI766484B/zh active
- 2020-12-21 UY UY0001038998A patent/UY38998A/es unknown
-
2022
- 2022-06-14 CO CONC2022/0008313A patent/CO2022008313A2/es unknown
- 2022-06-17 DO DO2022000130A patent/DOP2022000130A/es unknown
- 2022-06-17 CL CL2022001675A patent/CL2022001675A1/es unknown
- 2022-06-20 EC ECSENADI202249160A patent/ECSP22049160A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2023507138A (ja) | 2023-02-21 |
AU2020405536B2 (en) | 2023-09-07 |
BR112022011838A2 (pt) | 2022-08-30 |
US20210188829A1 (en) | 2021-06-24 |
WO2021124155A1 (en) | 2021-06-24 |
CL2022001675A1 (es) | 2023-03-17 |
PE20221916A1 (es) | 2022-12-23 |
DOP2022000130A (es) | 2022-07-31 |
IL293831B2 (en) | 2024-02-01 |
UY38998A (es) | 2021-07-30 |
KR20220118525A (ko) | 2022-08-25 |
TW202130634A (zh) | 2021-08-16 |
US11661419B2 (en) | 2023-05-30 |
CA3103120A1 (en) | 2021-06-20 |
CR20220299A (es) | 2022-08-05 |
AU2020405536A1 (en) | 2022-07-14 |
MX2022007518A (es) | 2022-09-19 |
TWI766484B (zh) | 2022-06-01 |
EP4077316A1 (en) | 2022-10-26 |
IL293831A (en) | 2022-08-01 |
IL293831B1 (en) | 2023-10-01 |
CO2022008313A2 (es) | 2022-07-08 |
CN115087655A (zh) | 2022-09-20 |
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