UY38926A - INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA - Google Patents

INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA

Info

Publication number
UY38926A
UY38926A UY0001038926A UY38926A UY38926A UY 38926 A UY38926 A UY 38926A UY 0001038926 A UY0001038926 A UY 0001038926A UY 38926 A UY38926 A UY 38926A UY 38926 A UY38926 A UY 38926A
Authority
UY
Uruguay
Prior art keywords
alfa4beta7
inhibition
human integrin
integrin
human
Prior art date
Application number
UY0001038926A
Other languages
English (en)
Spanish (es)
Inventor
Matthew G Bursavich
Dan Cui
James E Dowling
Kristopher N Hahn
Bryce A Harrison
fu-yang Lin
Blaise S Lippa
Dawn M Troast
Cheng Zhong
Kyle D Konze
Aleksey I Gerasyuto
Byungchan Kim
Salma Rafi
Tyler Day
Eugene Hickey
Evelyne Houang
Robert Zahler
Bruce N Rogers
Original Assignee
Morphic Therapeutic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphic Therapeutic Inc filed Critical Morphic Therapeutic Inc
Publication of UY38926A publication Critical patent/UY38926A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Radio Relay Systems (AREA)
  • Air Conditioning Control Device (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
UY0001038926A 2019-10-16 2020-10-16 INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA UY38926A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962916062P 2019-10-16 2019-10-16

Publications (1)

Publication Number Publication Date
UY38926A true UY38926A (es) 2021-05-31

Family

ID=73198501

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001038926A UY38926A (es) 2019-10-16 2020-10-16 INHIBICIÓN DE INTEGRINA alfa4beta7 HUMANA

Country Status (37)

Country Link
US (3) US11104661B1 (https=)
EP (3) EP4045039B1 (https=)
JP (7) JP7437490B2 (https=)
KR (2) KR20220102669A (https=)
CN (3) CN119192137A (https=)
AR (1) AR120244A1 (https=)
AU (2) AU2020366435A1 (https=)
BR (1) BR112022007284A2 (https=)
CA (1) CA3154269A1 (https=)
CL (1) CL2022000959A1 (https=)
CO (1) CO2022005759A2 (https=)
CR (1) CR20220205A (https=)
CU (1) CU20220027A7 (https=)
DK (1) DK4045039T3 (https=)
DO (2) DOP2022000081A (https=)
EC (1) ECSP22038978A (https=)
ES (1) ES3035561T3 (https=)
FI (1) FI4045039T3 (https=)
HR (1) HRP20250749T1 (https=)
HU (1) HUE071814T2 (https=)
IL (2) IL319053A (https=)
LT (1) LT4045039T (https=)
MA (1) MA57399B1 (https=)
MD (1) MD4045039T2 (https=)
MX (1) MX2022004406A (https=)
PE (1) PE20221829A1 (https=)
PH (1) PH12022550886A1 (https=)
PL (1) PL4045039T3 (https=)
PT (1) PT4045039T (https=)
PY (1) PY2065718A (https=)
RS (1) RS66976B1 (https=)
SI (1) SI4045039T1 (https=)
TW (7) TWI775182B (https=)
UA (1) UA130059C2 (https=)
UY (1) UY38926A (https=)
WO (3) WO2021076902A1 (https=)
ZA (2) ZA202203872B (https=)

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WO2020232256A1 (en) 2019-05-15 2020-11-19 Chemocentryx, Inc. Triaryl compounds for treatment of pd-l1 diseases
WO2021030438A1 (en) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
TWI775182B (zh) 2019-10-16 2022-08-21 美商莫菲克醫療股份有限公司 抑制人類整合素αβ
ES3064674T3 (en) 2019-10-16 2026-04-28 Chemocentryx Inc Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases
JP7736678B2 (ja) 2019-10-16 2025-09-09 ケモセントリックス,インコーポレイティド Pd-l1疾患の処置のためのヘテロアリール-ビフェニルアミド
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TW202508571A (zh) 2023-07-28 2025-03-01 大陸商上海翰森生物醫藥科技有限公司 一種苯并含氮雜環類衍生物調節劑、其製備方法和應用
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CN118702712B (zh) * 2024-07-04 2025-11-11 安徽普利药业有限公司 一种n-(3-苯10硼酸)-l-天冬氨酸中间体制备方法
WO2026018017A1 (en) * 2024-07-19 2026-01-22 C4X Discovery Limited Therapeutic compounds
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CN119504796B (zh) * 2024-11-20 2026-03-10 南通大学附属医院 一种具有抗肿瘤活性的化合物及其应用

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IL292296A (en) 2022-06-01
CL2022000959A1 (es) 2023-04-28
WO2021076890A4 (en) 2021-06-10
FI4045039T3 (fi) 2025-06-20
JP7702004B2 (ja) 2025-07-02
US20240174632A1 (en) 2024-05-30
MX2022004406A (es) 2022-08-25
LT4045039T (lt) 2025-08-11
JP7437495B2 (ja) 2024-02-22
SI4045039T1 (sl) 2025-07-31
WO2022081983A1 (en) 2022-04-21
JP2024116230A (ja) 2024-08-27
DK4045039T3 (da) 2025-06-30
EP4045039A1 (en) 2022-08-24
DOP2022000081A (es) 2022-07-31
PY2065718A (es) 2023-01-17
BR112022007284A2 (pt) 2022-07-05
CN115087444B (zh) 2024-09-17
TWI840047B (zh) 2024-04-21
TW202500558A (zh) 2025-01-01
TWI775182B (zh) 2022-08-21
ES3035561T3 (en) 2025-09-04
JP2022548809A (ja) 2022-11-22
TWI802477B (zh) 2023-05-11
UA130059C2 (uk) 2025-10-29
EP4045039B1 (en) 2025-04-23
TW202126624A (zh) 2021-07-16
JP2023500437A (ja) 2023-01-06
IL319053A (en) 2025-04-01
IL292296B1 (en) 2025-03-01
MA57399B1 (fr) 2025-06-30
TW202244040A (zh) 2022-11-16
JP7717202B2 (ja) 2025-08-01
EP4045039A4 (en) 2023-12-13
DOP2025000034A (es) 2025-04-08
TWI791304B (zh) 2023-02-01
CN116783161A (zh) 2023-09-19
KR20220102669A (ko) 2022-07-20
PH12022550886A1 (en) 2023-05-03
WO2021076902A1 (en) 2021-04-22
ZA202303992B (en) 2024-06-26
CN119192137A (zh) 2024-12-27
JP2024054296A (ja) 2024-04-16
EP4228634A4 (en) 2024-12-18
JP7500785B2 (ja) 2024-06-17
HUE071814T2 (hu) 2025-09-28
TW202500559A (zh) 2025-01-01
EP4559525A3 (en) 2025-08-20
TWI888065B (zh) 2025-06-21
JP7209116B2 (ja) 2023-01-19
US11104661B1 (en) 2021-08-31
HRP20250749T1 (hr) 2025-08-15
CU20220027A7 (es) 2022-12-12
ECSP22038978A (es) 2022-06-30
AR120244A1 (es) 2022-02-09
TW202332675A (zh) 2023-08-16
ZA202203872B (en) 2024-01-31
JP7437490B2 (ja) 2024-02-22
CN115087444A (zh) 2022-09-20
TWI900200B (zh) 2025-10-01
WO2021076890A1 (en) 2021-04-22
EP4559525A2 (en) 2025-05-28
CN116783161B (zh) 2026-04-03
CA3154269A1 (en) 2021-04-22
AU2021361031A1 (en) 2023-06-08
JP2024054293A (ja) 2024-04-16
TW202222793A (zh) 2022-06-16
TWI857592B (zh) 2024-10-01
AU2020366435A1 (en) 2022-04-21
JP2023036958A (ja) 2023-03-14
MD4045039T2 (ro) 2025-11-30
RS66976B1 (sr) 2025-07-31
US11370773B1 (en) 2022-06-28
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CR20220205A (es) 2022-07-22
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