CN119192137A - 抑制人整联蛋白α4β7 - Google Patents

抑制人整联蛋白α4β7 Download PDF

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Publication number
CN119192137A
CN119192137A CN202411308053.XA CN202411308053A CN119192137A CN 119192137 A CN119192137 A CN 119192137A CN 202411308053 A CN202411308053 A CN 202411308053A CN 119192137 A CN119192137 A CN 119192137A
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China
Prior art keywords
compound
substituted
unsubstituted
certain embodiments
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN202411308053.XA
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English (en)
Chinese (zh)
Inventor
马修·G·伯沙维奇
崔东晖
詹姆士·E·道龄
克里斯托夫·N·汉
拜尔斯·A·哈里森
林富扬
布雷斯·S·莉琶
布鲁斯·N·罗杰斯
唐·M·特洛斯特
钟诚
凯尔·D·康梓
艾力克西·I·杰洛西邬图
金丙澯
萨尔玛·拉菲
泰勒·帒
尤金·希克奇
埃弗利娜·霍昂
罗伯特·札勒
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Murphy Medical Co ltd
Original Assignee
Murphy Medical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Murphy Medical Co ltd filed Critical Murphy Medical Co ltd
Publication of CN119192137A publication Critical patent/CN119192137A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Radio Relay Systems (AREA)
  • Air Conditioning Control Device (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202411308053.XA 2019-10-16 2020-10-16 抑制人整联蛋白α4β7 Pending CN119192137A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962916062P 2019-10-16 2019-10-16
US62/916,062 2019-10-16
PCT/US2020/055986 WO2021076890A1 (en) 2019-10-16 2020-10-16 INHIBITING HUMAN INTEGRIN α4β7
CN202080088450.4A CN115087444B (zh) 2019-10-16 2020-10-16 抑制人整联蛋白α4β7

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN202080088450.4A Division CN115087444B (zh) 2019-10-16 2020-10-16 抑制人整联蛋白α4β7

Publications (1)

Publication Number Publication Date
CN119192137A true CN119192137A (zh) 2024-12-27

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN202411308053.XA Pending CN119192137A (zh) 2019-10-16 2020-10-16 抑制人整联蛋白α4β7
CN202080088450.4A Active CN115087444B (zh) 2019-10-16 2020-10-16 抑制人整联蛋白α4β7
CN202180083775.8A Active CN116783161B (zh) 2019-10-16 2021-10-15 抑制人整联蛋白a4b7

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CN202080088450.4A Active CN115087444B (zh) 2019-10-16 2020-10-16 抑制人整联蛋白α4β7
CN202180083775.8A Active CN116783161B (zh) 2019-10-16 2021-10-15 抑制人整联蛋白a4b7

Country Status (37)

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US (3) US11104661B1 (https=)
EP (3) EP4045039B1 (https=)
JP (7) JP7437490B2 (https=)
KR (2) KR20220102669A (https=)
CN (3) CN119192137A (https=)
AR (1) AR120244A1 (https=)
AU (2) AU2020366435A1 (https=)
BR (1) BR112022007284A2 (https=)
CA (1) CA3154269A1 (https=)
CL (1) CL2022000959A1 (https=)
CO (1) CO2022005759A2 (https=)
CR (1) CR20220205A (https=)
CU (1) CU20220027A7 (https=)
DK (1) DK4045039T3 (https=)
DO (2) DOP2022000081A (https=)
EC (1) ECSP22038978A (https=)
ES (1) ES3035561T3 (https=)
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HR (1) HRP20250749T1 (https=)
HU (1) HUE071814T2 (https=)
IL (2) IL319053A (https=)
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MA (1) MA57399B1 (https=)
MD (1) MD4045039T2 (https=)
MX (1) MX2022004406A (https=)
PE (1) PE20221829A1 (https=)
PH (1) PH12022550886A1 (https=)
PL (1) PL4045039T3 (https=)
PT (1) PT4045039T (https=)
PY (1) PY2065718A (https=)
RS (1) RS66976B1 (https=)
SI (1) SI4045039T1 (https=)
TW (7) TWI775182B (https=)
UA (1) UA130059C2 (https=)
UY (1) UY38926A (https=)
WO (3) WO2021076902A1 (https=)
ZA (2) ZA202203872B (https=)

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CL2022000959A1 (es) 2023-04-28
WO2021076890A4 (en) 2021-06-10
FI4045039T3 (fi) 2025-06-20
JP7702004B2 (ja) 2025-07-02
US20240174632A1 (en) 2024-05-30
MX2022004406A (es) 2022-08-25
LT4045039T (lt) 2025-08-11
JP7437495B2 (ja) 2024-02-22
SI4045039T1 (sl) 2025-07-31
WO2022081983A1 (en) 2022-04-21
JP2024116230A (ja) 2024-08-27
DK4045039T3 (da) 2025-06-30
EP4045039A1 (en) 2022-08-24
DOP2022000081A (es) 2022-07-31
PY2065718A (es) 2023-01-17
BR112022007284A2 (pt) 2022-07-05
CN115087444B (zh) 2024-09-17
TWI840047B (zh) 2024-04-21
TW202500558A (zh) 2025-01-01
TWI775182B (zh) 2022-08-21
ES3035561T3 (en) 2025-09-04
JP2022548809A (ja) 2022-11-22
TWI802477B (zh) 2023-05-11
UA130059C2 (uk) 2025-10-29
EP4045039B1 (en) 2025-04-23
TW202126624A (zh) 2021-07-16
JP2023500437A (ja) 2023-01-06
IL319053A (en) 2025-04-01
IL292296B1 (en) 2025-03-01
MA57399B1 (fr) 2025-06-30
TW202244040A (zh) 2022-11-16
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